CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available" lang="en" dir="ltr"> <head> <meta charset="UTF-8"> <title>Notch signaling pathway - Wikipedia</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )enwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":["",""],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"dmy", "wgMonthNames":["","January","February","March","April","May","June","July","August","September","October","November","December"],"wgRequestId":"af301e58-184a-4144-ae65-221c405261c1","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"Notch_signaling_pathway","wgTitle":"Notch signaling pathway","wgCurRevisionId":1246542080,"wgRevisionId":1246542080,"wgArticleId":1107334,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["All articles with dead external links","Articles with dead external links from April 2020","Articles with permanently dead external links","Wikipedia articles needing page number citations from February 2020","CS1 errors: requires URL","Articles with short description","Short description matches Wikidata","All articles with unsourced statements","Articles with unsourced statements from May 2007","Articles with unsourced statements from June 2007", "Articles with unsourced statements from August 2016","Articles containing potentially dated statements from 2013","All articles containing potentially dated statements","Webarchive template wayback links","Signal transduction"],"wgPageViewLanguage":"en","wgPageContentLanguage":"en","wgPageContentModel":"wikitext","wgRelevantPageName":"Notch_signaling_pathway","wgRelevantArticleId":1107334,"wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgRedirectedFrom":"Notch_pathway","wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false,"wgFlaggedRevsParams":{"tags":{"status":{"levels":1}}},"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"en","pageLanguageDir":"ltr","pageVariantFallbacks":"en"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":false,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false, "wgWMEPageLength":90000,"wgInternalRedirectTargetUrl":"/wiki/Notch_signaling_pathway","wgRelatedArticlesCompat":[],"wgCentralAuthMobileDomain":false,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q904082","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false,"wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false};RLSTATE={"ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","ext.math.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready", "jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"};RLPAGEMODULES=["mediawiki.action.view.redirect","ext.cite.ux-enhancements","mediawiki.page.media","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.ReferenceTooltips","ext.gadget.switcher","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups","ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.quicksurveys.init","ext.growthExperiments.SuggestedEditSession", "wikibase.sidebar.tracking"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=en&modules=ext.cite.styles%7Cext.math.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=en&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=en&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.4"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/0/04/Notchccr.svg/1200px-Notchccr.svg.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="1116"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/0/04/Notchccr.svg/800px-Notchccr.svg.png"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="744"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/0/04/Notchccr.svg/640px-Notchccr.svg.png"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="595"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="Notch signaling pathway - Wikipedia"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//en.m.wikipedia.org/wiki/Notch_signaling_pathway"> <link rel="alternate" type="application/x-wiki" title="Edit this page" href="/w/index.php?title=Notch_signaling_pathway&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (en)"> <link rel="EditURI" type="application/rsd+xml" href="//en.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://en.wikipedia.org/wiki/Notch_signaling_pathway"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en"> <link rel="alternate" type="application/atom+xml" title="Wikipedia Atom feed" href="/w/index.php?title=Special:RecentChanges&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="//login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-Notch_signaling_pathway rootpage-Notch_signaling_pathway skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Jump to content</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Main menu" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Main menu </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Main menu</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">hide</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigation </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Main_Page" title="Visit the main page [z]" accesskey="z">Main page</a></li><li id="n-contents" class="mw-list-item"><a href="/wiki/Wikipedia:Contents" title="Guides to browsing Wikipedia">Contents</a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:Current_events" title="Articles related to current events">Current events</a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Special:Random" title="Visit a randomly selected article [x]" accesskey="x">Random article</a></li><li id="n-aboutsite" class="mw-list-item"><a href="/wiki/Wikipedia:About" title="Learn about Wikipedia and how it works">About Wikipedia</a></li><li id="n-contactpage" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us" title="How to contact Wikipedia">Contact us</a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" > <div class="vector-menu-heading"> Contribute </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Help:Contents" title="Guidance on how to use and edit Wikipedia">Help</a></li><li id="n-introduction" class="mw-list-item"><a href="/wiki/Help:Introduction" title="Learn how to edit Wikipedia">Learn to edit</a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Community_portal" title="The hub for editors">Community portal</a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Special:RecentChanges" title="A list of recent changes to Wikipedia [r]" accesskey="r">Recent changes</a></li><li id="n-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_upload_wizard" title="Add images or other media for use on Wikipedia">Upload file</a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Main_Page" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="The Free Encyclopedia" src="/static/images/mobile/copyright/wikipedia-tagline-en.svg" width="117" height="13" style="width: 7.3125em; height: 0.8125em;"> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Special:Search" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Search Wikipedia [f]" accesskey="f"> Search </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Search Wikipedia" aria-label="Search Wikipedia" autocapitalize="sentences" title="Search Wikipedia [f]" accesskey="f" id="searchInput" > </div> <input type="hidden" name="title" value="Special:Search"> </div> <button class="cdx-button cdx-search-input__end-button">Search</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Personal tools"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Appearance" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Appearance </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en" class="">Donate</a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:CreateAccount&returnto=Notch+signaling+pathway" title="You are encouraged to create an account and log in; however, it is not mandatory" class="">Create account</a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:UserLogin&returnto=Notch+signaling+pathway" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o" class="">Log in</a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Log in and more options" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Personal tools" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Personal tools </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="User menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en">Donate</a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:CreateAccount&returnto=Notch+signaling+pathway" title="You are encouraged to create an account and log in; however, it is not mandatory"> Create account</a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:UserLogin&returnto=Notch+signaling+pathway" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o"> Log in</a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pages for logged out editors <a href="/wiki/Help:Introduction" aria-label="Learn more about editing">learn more</a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:MyContributions" title="A list of edits made from this IP address [y]" accesskey="y">Contributions</a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:MyTalk" title="Discussion about edits from this IP address [n]" accesskey="n">Talk</a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Contents" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Contents</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Discovery" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Discovery"> <div class="vector-toc-text"> 1 Discovery </div> </a> <ul id="toc-Discovery-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mechanism" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Mechanism"> <div class="vector-toc-text"> 2 Mechanism </div> </a> <button aria-controls="toc-Mechanism-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Mechanism subsection </button> <ul id="toc-Mechanism-sublist" class="vector-toc-list"> <li id="toc-Pathway" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pathway"> <div class="vector-toc-text"> 2.1 Pathway </div> </a> <ul id="toc-Pathway-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Ligand_interactions" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Ligand_interactions"> <div class="vector-toc-text"> 2.2 Ligand interactions </div> </a> <ul id="toc-Ligand_interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Synthetic_Notch_signaling" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Synthetic_Notch_signaling"> <div class="vector-toc-text"> 2.3 Synthetic Notch signaling </div> </a> <ul id="toc-Synthetic_Notch_signaling-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> 3 Function </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_in_embryogenesis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Role_in_embryogenesis"> <div class="vector-toc-text"> 4 Role in embryogenesis </div> </a> <button aria-controls="toc-Role_in_embryogenesis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Role in embryogenesis subsection </button> <ul id="toc-Role_in_embryogenesis-sublist" class="vector-toc-list"> <li id="toc-Embryo_polarity" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Embryo_polarity"> <div class="vector-toc-text"> 4.1 Embryo polarity </div> </a> <ul id="toc-Embryo_polarity-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_in_somitogenesis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Role_in_somitogenesis"> <div class="vector-toc-text"> 4.2 Role in somitogenesis </div> </a> <ul id="toc-Role_in_somitogenesis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_in_epidermal_differentiation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Role_in_epidermal_differentiation"> <div class="vector-toc-text"> 4.3 Role in epidermal differentiation </div> </a> <ul id="toc-Role_in_epidermal_differentiation-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Role_in_central_nervous_system_development_and_function" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Role_in_central_nervous_system_development_and_function"> <div class="vector-toc-text"> 5 Role in central nervous system development and function </div> </a> <button aria-controls="toc-Role_in_central_nervous_system_development_and_function-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Role in central nervous system development and function subsection </button> <ul id="toc-Role_in_central_nervous_system_development_and_function-sublist" class="vector-toc-list"> <li id="toc-Neuron_cell_differentiation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Neuron_cell_differentiation"> <div class="vector-toc-text"> 5.1 Neuron cell differentiation </div> </a> <ul id="toc-Neuron_cell_differentiation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Neurite_development" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Neurite_development"> <div class="vector-toc-text"> 5.2 Neurite development </div> </a> <ul id="toc-Neurite_development-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gliogenesis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gliogenesis"> <div class="vector-toc-text"> 5.3 Gliogenesis </div> </a> <ul id="toc-Gliogenesis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Adult_brain_function" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Adult_brain_function"> <div class="vector-toc-text"> 5.4 Adult brain function </div> </a> <ul id="toc-Adult_brain_function-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Role_in_cardiovascular_development" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Role_in_cardiovascular_development"> <div class="vector-toc-text"> 6 Role in cardiovascular development </div> </a> <button aria-controls="toc-Role_in_cardiovascular_development-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Role in cardiovascular development subsection </button> <ul id="toc-Role_in_cardiovascular_development-sublist" class="vector-toc-list"> <li id="toc-Cardiac_development" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cardiac_development"> <div class="vector-toc-text"> 6.1 Cardiac development </div> </a> <ul id="toc-Cardiac_development-sublist" class="vector-toc-list"> <li id="toc-Atrioventricular_(AV)_canal_development" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Atrioventricular_(AV)_canal_development"> <div class="vector-toc-text"> 6.1.1 Atrioventricular (AV) canal development </div> </a> <ul id="toc-Atrioventricular_(AV)_canal_development-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Ventricular_development" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Ventricular_development"> <div class="vector-toc-text"> 6.1.2 Ventricular development </div> </a> <ul id="toc-Ventricular_development-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Ventricular_outflow_tract_development" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Ventricular_outflow_tract_development"> <div class="vector-toc-text"> 6.1.3 Ventricular outflow tract development </div> </a> <ul id="toc-Ventricular_outflow_tract_development-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Angiogenesis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Angiogenesis"> <div class="vector-toc-text"> 6.2 Angiogenesis </div> </a> <ul id="toc-Angiogenesis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Role_in_endocrine_development" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Role_in_endocrine_development"> <div class="vector-toc-text"> 7 Role in endocrine development </div> </a> <button aria-controls="toc-Role_in_endocrine_development-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Role in endocrine development subsection </button> <ul id="toc-Role_in_endocrine_development-sublist" class="vector-toc-list"> <li id="toc-Pancreatic_development" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pancreatic_development"> <div class="vector-toc-text"> 7.1 Pancreatic development </div> </a> <ul id="toc-Pancreatic_development-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Intestinal_development" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Intestinal_development"> <div class="vector-toc-text"> 7.2 Intestinal development </div> </a> <ul id="toc-Intestinal_development-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bone_development" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Bone_development"> <div class="vector-toc-text"> 7.3 Bone development </div> </a> <ul id="toc-Bone_development-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Role_in_cancer" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Role_in_cancer"> <div class="vector-toc-text"> 8 Role in cancer </div> </a> <button aria-controls="toc-Role_in_cancer-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Role in cancer subsection </button> <ul id="toc-Role_in_cancer-sublist" class="vector-toc-list"> <li id="toc-Leukemia" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Leukemia"> <div class="vector-toc-text"> 8.1 Leukemia </div> </a> <ul id="toc-Leukemia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Urothelial_bladder_cancer" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Urothelial_bladder_cancer"> <div class="vector-toc-text"> 8.2 Urothelial bladder cancer </div> </a> <ul id="toc-Urothelial_bladder_cancer-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liver_cancer" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Liver_cancer"> <div class="vector-toc-text"> 8.3 Liver cancer </div> </a> <ul id="toc-Liver_cancer-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Notch_inhibitors" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Notch_inhibitors"> <div class="vector-toc-text"> 9 Notch inhibitors </div> </a> <ul id="toc-Notch_inhibitors-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mathematical_modeling" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Mathematical_modeling"> <div class="vector-toc-text"> 10 Mathematical modeling </div> </a> <ul id="toc-Mathematical_modeling-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> 11 See also </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> 12 References </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> 13 External links </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Toggle the table of contents </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading">Notch signaling pathway</h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 12 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-12" aria-hidden="true" > 12 languages </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Notch_receptor" title="Notch receptor – Czech" lang="cs" hreflang="cs" data-title="Notch receptor" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target">Čeština</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Notch-Signalweg" title="Notch-Signalweg – German" lang="de" hreflang="de" data-title="Notch-Signalweg" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Ruta_de_se%C3%B1alizaci%C3%B3n_Notch" title="Ruta de señalización Notch – Spanish" lang="es" hreflang="es" data-title="Ruta de señalización Notch" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Voie_de_signalisation_Notch" title="Voie de signalisation Notch – French" lang="fr" hreflang="fr" data-title="Voie de signalisation Notch" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Jalur_persinyalan_Notch" title="Jalur persinyalan Notch – Indonesian" lang="id" hreflang="id" data-title="Jalur persinyalan Notch" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target">Bahasa Indonesia</a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Notch" title="Notch – Italian" lang="it" hreflang="it" data-title="Notch" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target">Italiano</a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Significans_iter_NOTCH" title="Significans iter NOTCH – Latin" lang="la" hreflang="la" data-title="Significans iter NOTCH" data-language-autonym="Latina" data-language-local-name="Latin" class="interlanguage-link-target">Latina</a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Notch-jelz%C5%91%C3%BAt" title="Notch-jelzőút – Hungarian" lang="hu" hreflang="hu" data-title="Notch-jelzőút" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target">Magyar</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/Notch%E3%82%B7%E3%82%B0%E3%83%8A%E3%83%AA%E3%83%B3%E3%82%B0" title="Notchシグナリング – Japanese" lang="ja" hreflang="ja" data-title="Notchシグナリング" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Via_de_sinaliza%C3%A7%C3%A3o_Notch" title="Via de sinalização Notch – Portuguese" lang="pt" hreflang="pt" data-title="Via de sinalização Notch" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target">Português</a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A1%D0%B8%D0%B3%D0%BD%D0%B0%D0%BB%D1%8C%D0%BD%D0%B8%D0%B9_%D1%88%D0%BB%D1%8F%D1%85_Notch" title="Сигнальний шлях Notch – Ukrainian" lang="uk" hreflang="uk" data-title="Сигнальний шлях Notch" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target">Українська</a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/Notch%E4%BF%A1%E5%8F%B7%E9%80%9A%E8%B7%AF" title="Notch信号通路 – Chinese" lang="zh" hreflang="zh" data-title="Notch信号通路" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target">中文</a></li> </ul> <div class="after-portlet after-portlet-lang"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q904082#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Notch_signaling_pathway" title="View the content page [c]" accesskey="c">Article</a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Notch_signaling_pathway" rel="discussion" title="Discuss improvements to the content page [t]" accesskey="t">Talk</a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Change language variant" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" >English </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Views"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Notch_signaling_pathway">Read</a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Notch_signaling_pathway&action=edit" title="Edit this page [e]" accesskey="e">Edit</a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Notch_signaling_pathway&action=history" title="Past revisions of this page [h]" accesskey="h">View history</a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Tools" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" >Tools </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Tools</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">hide</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="More options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Notch_signaling_pathway">Read</a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Notch_signaling_pathway&action=edit" title="Edit this page [e]" accesskey="e">Edit</a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Notch_signaling_pathway&action=history">View history</a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> General </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:WhatLinksHere/Notch_signaling_pathway" title="List of all English Wikipedia pages containing links to this page [j]" accesskey="j">What links here</a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:RecentChangesLinked/Notch_signaling_pathway" rel="nofollow" title="Recent changes in pages linked from this page [k]" accesskey="k">Related changes</a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_Upload_Wizard" title="Upload files [u]" accesskey="u">Upload file</a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Special:SpecialPages" title="A list of all special pages [q]" accesskey="q">Special pages</a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Notch_signaling_pathway&oldid=1246542080" title="Permanent link to this revision of this page">Permanent link</a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Notch_signaling_pathway&action=info" title="More information about this page">Page information</a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:CiteThisPage&page=Notch_signaling_pathway&id=1246542080&wpFormIdentifier=titleform" title="Information on how to cite this page">Cite this page</a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:UrlShortener&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FNotch_signaling_pathway">Get shortened URL</a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FNotch_signaling_pathway">Download QR code</a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=Notch_signaling_pathway&action=show-download-screen" title="Download this page as a PDF file">Download as PDF</a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Notch_signaling_pathway&printable=yes" title="Printable version of this page [p]" accesskey="p">Printable version</a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Notch_signaling_pathway" hreflang="en">Wikimedia Commons</a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q904082" title="Structured data on this page hosted by Wikidata [g]" accesskey="g">Wikidata item</a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle">(Redirected from <a href="/w/index.php?title=Notch_pathway&redirect=no" class="mw-redirect" title="Notch pathway">Notch pathway</a>)</div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Series of molecular signals</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Notchccr.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Notchccr.svg/220px-Notchccr.svg.png" decoding="async" width="220" height="205" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Notchccr.svg/330px-Notchccr.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/04/Notchccr.svg/440px-Notchccr.svg.png 2x" data-file-width="500" data-file-height="465" /></a><figcaption>Notch-mediated <a href="/wiki/Juxtacrine_signalling" title="Juxtacrine signalling">juxtacrine signal</a> between adjacent cells</figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Notch_signaling.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/92/Notch_signaling.svg/220px-Notch_signaling.svg.png" decoding="async" width="220" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/92/Notch_signaling.svg/330px-Notch_signaling.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/92/Notch_signaling.svg/440px-Notch_signaling.svg.png 2x" data-file-width="400" data-file-height="400" /></a><figcaption>Notch signaling steps</figcaption></figure> The Notch signaling pathway is a highly <a href="/wiki/Conserved_sequence" title="Conserved sequence">conserved</a> <a href="/wiki/Cell_signaling" title="Cell signaling">cell signaling</a> system present in most <a href="/wiki/Animal" title="Animal">animals</a>.<a href="#cite_note-pmid10221902-1">[1]</a> Mammals possess four different <a href="/wiki/Notch_proteins" title="Notch proteins">notch receptors</a>, referred to as <a href="/wiki/NOTCH1" class="mw-redirect" title="NOTCH1">NOTCH1</a>, <a href="/wiki/NOTCH2" class="mw-redirect" title="NOTCH2">NOTCH2</a>, <a href="/wiki/Notch_3" class="mw-redirect" title="Notch 3">NOTCH3</a>, and <a href="/wiki/NOTCH4" class="mw-redirect" title="NOTCH4">NOTCH4</a>.<a href="#cite_note-ReferenceB-2">[2]</a> The notch receptor is a single-pass <a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">transmembrane receptor</a> protein. It is a <a href="/wiki/Hetero-oligomer" class="mw-redirect" title="Hetero-oligomer">hetero-oligomer</a> composed of a large <a href="/wiki/Extracellular" class="mw-redirect" title="Extracellular">extracellular</a> portion, which associates in a <a href="/wiki/Calcium" title="Calcium">calcium</a>-dependent, <a href="/wiki/Non-covalent" class="mw-redirect" title="Non-covalent">non-covalent</a> interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small <a href="/wiki/Intracellular" class="mw-redirect" title="Intracellular">intracellular</a> region.<a href="#cite_note-pmid10882063-3">[3]</a> Notch signaling promotes proliferative signaling during <a href="/wiki/Neurogenesis" title="Neurogenesis">neurogenesis</a>, and its activity is inhibited by <a href="/wiki/NUMB_(gene)" title="NUMB (gene)">Numb</a> to promote neural differentiation. It plays a major role in the regulation of embryonic development. Notch signaling is dysregulated in many cancers, and faulty notch signaling is implicated in many diseases, including T-cell acute lymphoblastic leukemia (<a href="/wiki/Precursor_T_acute_lymphoblastic_leukemia/lymphoma" class="mw-redirect" title="Precursor T acute lymphoblastic leukemia/lymphoma">T-ALL</a>),<a href="#cite_note-pmid17404512-4">[4]</a> cerebral autosomal-dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy (CADASIL), multiple sclerosis, <a href="/wiki/Tetralogy_of_Fallot" title="Tetralogy of Fallot">Tetralogy of Fallot</a>, and <a href="/wiki/Alagille_syndrome" title="Alagille syndrome">Alagille syndrome</a>. Inhibition of notch signaling inhibits the proliferation of T-cell acute lymphoblastic leukemia in both cultured cells and a mouse model.<a href="#cite_note-5">[5]</a><a href="#cite_note-6">[6]</a> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Discovery">Discovery</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=1" title="Edit section: Discovery">edit</a>]</div> In 1914, John S. Dexter noticed the appearance of a notch in the wings of the fruit fly <a href="/wiki/Drosophila_melanogaster" title="Drosophila melanogaster">Drosophila melanogaster</a>. The <a href="/wiki/Alleles" class="mw-redirect" title="Alleles">alleles</a> of the gene were identified in 1917 by American evolutionary biologist <a href="/wiki/Thomas_Hunt_Morgan" title="Thomas Hunt Morgan">Thomas Hunt Morgan</a>.<a href="#cite_note-Morgan1917-7">[7]</a><a href="#cite_note-8">[8]</a> Its molecular analysis and sequencing was independently undertaken in the 1980s by <a href="/wiki/Spyros_Artavanis-Tsakonas" class="mw-redirect" title="Spyros Artavanis-Tsakonas">Spyros Artavanis-Tsakonas</a> and <a href="/wiki/Michael_W._Young" title="Michael W. Young">Michael W. Young</a>.<a href="#cite_note-pmid3935325-9">[9]</a><a href="#cite_note-pmid3097517-10">[10]</a> Alleles of the two <a href="/wiki/Caenorhabditis_elegans" title="Caenorhabditis elegans">C. elegans</a> Notch genes were identified based on developmental phenotypes: lin-12<a href="#cite_note-11">[11]</a> and glp-1.<a href="#cite_note-pmid3677168-12">[12]</a><a href="#cite_note-PMID3677169-13">[13]</a> The cloning and partial sequence of lin-12 was reported at the same time as Drosophila Notch by Iva Greenwald.<a href="#cite_note-PMID3000611-14">[14]</a> <div class="mw-heading mw-heading2"><h2 id="Mechanism">Mechanism</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=2" title="Edit section: Mechanism">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/Notch_protein" class="mw-redirect" title="Notch protein">Notch protein</a></div> The <a href="/wiki/Notch_protein" class="mw-redirect" title="Notch protein">Notch protein</a> spans the <a href="/wiki/Cell_membrane" title="Cell membrane">cell membrane</a>, with part of it inside and part outside. <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">Ligand</a> proteins binding to the extracellular domain induce proteolytic cleavage and release of the intracellular domain, which enters the <a href="/wiki/Cell_nucleus" title="Cell nucleus">cell nucleus</a> to modify <a href="/wiki/Gene_expression" title="Gene expression">gene expression</a>.<a href="#cite_note-pmid11604511-15">[15]</a> The cleavage model was first proposed in 1993 based on work done with Drosophila Notch and C. elegans lin-12,<a href="#cite_note-PMID8406001-16">[16]</a><a href="#cite_note-PMID8343960-17">[17]</a> informed by the first oncogenic mutation affecting a human Notch gene.<a href="#cite_note-PMID1831692-18">[18]</a> Compelling evidence for this model was provided in 1998 by in vivo analysis in Drosophila by Gary Struhl<a href="#cite_note-PMID9604939-19">[19]</a> and in cell culture by Raphael Kopan.<a href="#cite_note-PMID9620803-20">[20]</a> Although this model was initially disputed,<a href="#cite_note-pmid10221902-1">[1]</a> the evidence in favor of the model was irrefutable by 2001.<a href="#cite_note-PMID22785620-21">[21]</a><a href="#cite_note-PMID11134525-22">[22]</a> The receptor is normally triggered via direct cell-to-cell contact, in which the transmembrane proteins of the cells in direct contact form the ligands that bind the notch receptor. The Notch binding allows groups of cells to organize themselves such that, if one cell expresses a given trait, this may be switched off in neighbouring cells by the intercellular notch signal. In this way, groups of cells influence one another to make large structures. Thus, lateral inhibition mechanisms are key to Notch signaling. lin-12 and Notch mediate binary cell fate decisions, and lateral inhibition involves feedback mechanisms to amplify initial differences.<a href="#cite_note-PMID22785620-21">[21]</a> The Notch cascade consists of Notch and Notch <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligands</a>, as well as intracellular proteins transmitting the notch signal to the cell's nucleus. The Notch/Lin-12/Glp-1 receptor family<a href="#cite_note-pmid7716513-23">[23]</a> was found to be involved in the specification of cell fates during development in Drosophila and C. elegans.<a href="#cite_note-pmid9546393-24">[24]</a> The intracellular domain of Notch forms a complex with <a href="/wiki/RBPJ" title="RBPJ">CBF1</a> and <a href="/wiki/MAML1" title="MAML1">Mastermind</a> to activate transcription of target genes. The structure of the complex has been determined.<a href="#cite_note-PMID16530044-25">[25]</a><a href="#cite_note-PMID16530045-26">[26]</a> <div class="mw-heading mw-heading3"><h3 id="Pathway">Pathway</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=3" title="Edit section: Pathway">edit</a>]</div> Maturation of the notch receptor involves cleavage at the prospective extracellular side during intracellular trafficking in the Golgi complex.<a href="#cite_note-pmid10899003-27">[27]</a> This results in a bipartite protein, composed of a large extracellular domain linked to the smaller transmembrane and intracellular domain. Binding of ligand promotes two proteolytic processing events; as a result of proteolysis, the intracellular domain is liberated and can enter the nucleus to engage other DNA-binding proteins and regulate gene expression. Notch and most of its ligands are transmembrane proteins, so the cells expressing the ligands typically must be adjacent to the notch expressing cell for signaling to occur.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] The notch ligands are also single-pass transmembrane proteins and are members of the DSL (Delta/Serrate/LAG-2) family of proteins. In <a href="/wiki/Drosophila_melanogaster" title="Drosophila melanogaster">Drosophila melanogaster</a> (the fruit fly), there are two ligands named <a href="/wiki/Delta_(ligand)" class="mw-redirect" title="Delta (ligand)">Delta</a> and <a href="/w/index.php?title=Serrate_(ligand)&action=edit&redlink=1" class="new" title="Serrate (ligand) (page does not exist)">Serrate</a>. In mammals, the corresponding names are <a href="/w/index.php?title=Delta-like&action=edit&redlink=1" class="new" title="Delta-like (page does not exist)">Delta-like</a> and <a href="/wiki/Jagged_(ligand)" class="mw-redirect" title="Jagged (ligand)">Jagged</a>. In mammals there are multiple Delta-like and Jagged ligands, as well as possibly a variety of other ligands, such as F3/contactin.<a href="#cite_note-Lai-28">[28]</a> In the nematode <a href="/wiki/Caenorhabditis_elegans" title="Caenorhabditis elegans">C. elegans</a>, two genes encode homologous proteins, glp-1 and lin-12. There has been at least one report that suggests that some cells can send out processes that allow signaling to occur between cells that are as much as four or five cell diameters apart.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] The notch extracellular domain is composed primarily of small cystine-rich motifs called <a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF</a>-like repeats.<a href="#cite_note-pmid16973733-29">[29]</a> Notch 1, for example, has 36 of these repeats. Each EGF-like repeat is composed of approximately 40 amino acids, and its structure is defined largely by six conserved cysteine residues that form three conserved disulfide bonds. Each EGF-like repeat can be modified by <a href="/wiki/Glycans" class="mw-redirect" title="Glycans">O-linked glycans</a> at specific sites.<a href="#cite_note-pmid12460944-30">[30]</a> An <a href="/wiki/Glycosylation" title="Glycosylation">O-glucose</a> sugar may be added between the first and second conserved cysteines, and an <a href="/wiki/Glycosylation" title="Glycosylation">O-fucose</a> may be added between the second and third conserved cysteines. These sugars are added by an as-yet-unidentified <a href="/wiki/Glycosylation" title="Glycosylation">O-glucosyltransferase</a> (except for <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/18243100">Rumi</a>), and <a href="/wiki/GDP-fucose_Protein_O-fucosyltransferase_1" class="mw-redirect" title="GDP-fucose Protein O-fucosyltransferase 1">GDP-fucose Protein O-fucosyltransferase 1</a> (<a href="/wiki/GDP-fucose_Protein_O-fucosyltransferase_1" class="mw-redirect" title="GDP-fucose Protein O-fucosyltransferase 1">POFUT1</a>), respectively. The addition of <a href="/wiki/Glycosylation" title="Glycosylation">O-fucose</a> by <a href="/wiki/GDP-fucose_Protein_O-fucosyltransferase_1" class="mw-redirect" title="GDP-fucose Protein O-fucosyltransferase 1">POFUT1</a> is absolutely necessary for notch function, and, without the enzyme to add O-fucose, all notch proteins fail to function properly. As yet, the manner by which the glycosylation of notch affects function is not completely understood. The O-glucose on notch can be further elongated to a trisaccharide with the addition of two <a href="/wiki/Xylose" title="Xylose">xylose</a> sugars by <a href="/wiki/Xylose" title="Xylose">xylosyltransferases</a>, and the <a href="/wiki/Glycosylation" title="Glycosylation">O-fucose</a> can be elongated to a tetrasaccharide by the ordered addition of an <a href="/wiki/N-acetylglucosamine" class="mw-redirect" title="N-acetylglucosamine">N-acetylglucosamine</a> (GlcNAc) sugar by an <a href="/wiki/N-acetylglucosamine" class="mw-redirect" title="N-acetylglucosamine">N-Acetylglucosaminyltransferase</a> called <a href="/wiki/Fringe_Genes" class="mw-redirect" title="Fringe Genes">Fringe</a>, the addition of a <a href="/wiki/Galactose" title="Galactose">galactose</a> by a <a href="/wiki/Galactose" title="Galactose">galactosyltransferase</a>, and the addition of a <a href="/wiki/Sialic_acid" title="Sialic acid">sialic acid</a> by a <a href="/wiki/Sialic_acid" title="Sialic acid">sialyltransferase</a>.<a href="#cite_note-pmid17132502-31">[31]</a> To add another level of complexity, in mammals there are three Fringe GlcNAc-transferases, named lunatic fringe, manic fringe, and radical fringe. These enzymes are responsible for something called a "fringe effect" on notch signaling.<a href="#cite_note-pmid17215308-32">[32]</a> If Fringe adds a GlcNAc to the <a href="/wiki/Glycosylation" title="Glycosylation">O-fucose</a> sugar then the subsequent addition of a galactose and sialic acid will occur. In the presence of this tetrasaccharide, notch signals strongly when it interacts with the Delta ligand, but has markedly inhibited signaling when interacting with the Jagged ligand.<a href="#cite_note-pmid12826675-33">[33]</a> The means by which this addition of sugar inhibits signaling through one ligand, and potentiates signaling through another is not clearly understood. Once the notch extracellular domain interacts with a ligand, an ADAM-family <a href="/wiki/Metalloprotease" class="mw-redirect" title="Metalloprotease">metalloprotease</a> called ADAM10, cleaves the notch protein just outside the membrane.<a href="#cite_note-pmid19726682-34">[34]</a> This releases the extracellular portion of notch (NECD), which continues to interact with the ligand. The ligand plus the notch extracellular domain is then <a href="/wiki/Endocytosis" title="Endocytosis">endocytosed</a> by the ligand-expressing cell. There may be signaling effects in the ligand-expressing cell after endocytosis; this part of notch signaling is a topic of active research.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] After this first cleavage, an enzyme called <a href="/wiki/Gamma-secretase" class="mw-redirect" title="Gamma-secretase">γ-secretase</a> (which is implicated in <a href="/wiki/Alzheimer%27s_disease" title="Alzheimer's disease">Alzheimer's disease</a>) cleaves the remaining part of the notch protein just inside the inner leaflet of the <a href="/wiki/Cell_membrane" title="Cell membrane">cell membrane</a> of the notch-expressing cell. This releases the intracellular domain of the notch protein (NICD), which then moves to the <a href="/wiki/Cell_nucleus" title="Cell nucleus">nucleus</a>, where it can regulate gene expression by activating the <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factor</a> <a href="/wiki/RBPJ" title="RBPJ">CSL</a>. It was originally thought that these CSL proteins suppressed Notch target transcription. However, further research showed that, when the intracellular domain binds to the complex, it switches from a repressor to an activator of transcription.<a href="#cite_note-35">[35]</a> Other proteins also participate in the intracellular portion of the notch signaling cascade.<a href="#cite_note-pmid22223095-36">[36]</a> <div class="mw-heading mw-heading3"><h3 id="Ligand_interactions">Ligand interactions</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=4" title="Edit section: Ligand interactions">edit</a>]</div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:N1_dll4_cells.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/N1_dll4_cells.png/225px-N1_dll4_cells.png" decoding="async" width="225" height="455" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/N1_dll4_cells.png/337px-N1_dll4_cells.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8c/N1_dll4_cells.png/449px-N1_dll4_cells.png 2x" data-file-width="588" data-file-height="1190" /></a><figcaption>Crystal structure of the Notch1-DLL4 complex depicted as the interaction is predicted to occur between two cells (PDB ID: 4XLW)</figcaption></figure> Notch signaling is initiated when Notch receptors on the cell surface engage ligands presented in trans on opposing cells. Despite the expansive size of the Notch extracellular domain, it has been demonstrated that EGF domains 11 and 12 are the critical determinants for interactions with Delta.<a href="#cite_note-37">[37]</a> Additional studies have implicated regions outside of Notch EGF11-12 in ligand binding. For example, Notch EGF domain 8 plays a role in selective recognition of Serrate/Jagged<a href="#cite_note-38">[38]</a> and EGF domains 6-15 are required for maximal signaling upon ligand stimulation.<a href="#cite_note-39">[39]</a> A crystal structure of the interacting regions of Notch1 and Delta-like 4 (Dll4) provided a molecular-level visualization of Notch-ligand interactions, and revealed that the N-terminal MNNL (or C2) and DSL domains of ligands bind to Notch EGF domains 12 and 11, respectively.<a href="#cite_note-Luca_2015-40">[40]</a> The Notch1-Dll4 structure also illuminated a direct role for Notch O-linked fucose and glucose moieties in ligand recognition, and rationalized a structural mechanism for the glycan-mediated tuning of Notch signaling.<a href="#cite_note-Luca_2015-40">[40]</a> <div class="mw-heading mw-heading3"><h3 id="Synthetic_Notch_signaling">Synthetic Notch signaling</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=5" title="Edit section: Synthetic Notch signaling">edit</a>]</div> It is possible to engineer synthetic Notch receptors by replacing the extracellular receptor and intracellular transcriptional domains with other domains of choice. This allows researchers to select which ligands are detected, and which genes are upregulated in response. Using this technology, cells can report or change their behavior in response to contact with user-specified signals, facilitating new avenues of both basic and applied research into cell-cell signaling.<a href="#cite_note-Harmansa-41">[41]</a> Notably, this system allows multiple synthetic pathways to be engineered into a cell in parallel.<a href="#cite_note-42">[42]</a><a href="#cite_note-43">[43]</a> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=6" title="Edit section: Function">edit</a>]</div> The Notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch signaling also has a role in the following processes: <dl><dd><ul><li><a href="/wiki/Neuron" title="Neuron">neuronal</a> function and development<a href="#cite_note-pmid12052917-44">[44]</a><a href="#cite_note-pmid17409286-45">[45]</a><a href="#cite_note-pmid20844536-46">[46]</a><a href="#cite_note-pmid11937492-47">[47]</a></li> <li>stabilization of arterial endothelial fate and <a href="/wiki/Angiogenesis" title="Angiogenesis">angiogenesis</a><a href="#cite_note-pmid12482957-48">[48]</a></li> <li>regulation of crucial cell communication events between <a href="/wiki/Endocardium" title="Endocardium">endocardium</a> and <a href="/wiki/Myocardium" class="mw-redirect" title="Myocardium">myocardium</a> during both the formation of the valve primordial and <a href="/wiki/Ventricle_(heart)" title="Ventricle (heart)">ventricular</a> development and differentiation<a href="#cite_note-Grego-Bessa_2007-49">[49]</a></li> <li><a href="/wiki/Cardiac_valve" class="mw-redirect" title="Cardiac valve">cardiac valve</a> <a href="/wiki/Homeostasis" title="Homeostasis">homeostasis</a>, as well as implications in other human disorders involving the cardiovascular system<a href="#cite_note-50">[50]</a></li> <li>timely cell lineage specification of both <a href="/wiki/Endocrine_pancreas" class="mw-redirect" title="Endocrine pancreas">endocrine</a> and <a href="/wiki/Exocrine_pancreas" class="mw-redirect" title="Exocrine pancreas">exocrine pancreas</a><a href="#cite_note-pmid14657333-51">[51]</a></li> <li>influencing of binary fate decisions of cells that must choose between the secretory and absorptive lineages in the gut<a href="#cite_note-pmid15034002-52">[52]</a></li> <li>expansion of the <a href="/wiki/Hematopoietic_stem_cell" title="Hematopoietic stem cell">hematopoietic stem cell</a> compartment during bone development and participation in commitment to the <a href="/wiki/Osteoblast" title="Osteoblast">osteoblastic</a> lineage, suggesting a potential therapeutic role for notch in bone regeneration and osteoporosis<a href="#cite_note-pmid15695512-53">[53]</a></li> <li>expansion of the hemogenic endothelial cells along with signaling axis involving <a href="/wiki/Hedgehog_signaling_pathway" title="Hedgehog signaling pathway">Hedgehog signaling</a> and <a href="/wiki/TAL1" title="TAL1">Scl</a><a href="#cite_note-pmid23236128-54">[54]</a></li> <li><a href="/wiki/T_cell" title="T cell">T cell</a> lineage commitment from common lymphoid precursor <a href="#cite_note-55">[55]</a></li> <li>regulation of cell-fate decision in <a href="/wiki/Mammary_gland" title="Mammary gland">mammary glands</a> at several distinct development stages<a href="#cite_note-pmid15535842-56">[56]</a></li> <li>possibly some non-nuclear mechanisms, such as control of the <a href="/wiki/Actin" title="Actin">actin</a> <a href="/wiki/Cytoskeleton" title="Cytoskeleton">cytoskeleton</a> through the <a href="/wiki/Tyrosine_kinase" title="Tyrosine kinase">tyrosine kinase</a> <a href="/wiki/Abl_gene" class="mw-redirect" title="Abl gene">Abl</a><a href="#cite_note-Lai-28">[28]</a></li> <li>Regulation of the mitotic/meiotic decision in the C. elegans germline<a href="#cite_note-pmid3677168-12">[12]</a></li> <li>development of <a href="/wiki/Pulmonary_alveolus" title="Pulmonary alveolus">alveoli</a> in the <a href="/wiki/Lung" title="Lung">lung</a>.<a href="#cite_note-57">[57]</a></li></ul></dd></dl> It has also been found that <a href="/wiki/Rex1" title="Rex1">Rex1</a> has inhibitory effects on the expression of notch in <a href="/wiki/Mesenchymal_stem_cell" title="Mesenchymal stem cell">mesenchymal stem cells</a>, preventing differentiation.<a href="#cite_note-58">[58]</a> <div class="mw-heading mw-heading2"><h2 id="Role_in_embryogenesis">Role in embryogenesis</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=7" title="Edit section: Role in embryogenesis">edit</a>]</div> The Notch signaling pathway plays an important role in cell-cell communication, and further regulates embryonic development. <div class="mw-heading mw-heading3"><h3 id="Embryo_polarity">Embryo polarity</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=8" title="Edit section: Embryo polarity">edit</a>]</div> Notch signaling is required in the regulation of polarity. For example, mutation experiments have shown that loss of Notch signaling causes abnormal anterior-posterior polarity in <a href="/wiki/Somites" class="mw-redirect" title="Somites">somites</a>.<a href="#cite_note-59">[59]</a> Also, Notch signaling is required during left-right asymmetry determination in vertebrates.<a href="#cite_note-60">[60]</a> Early studies in the <a href="/wiki/Nematode" title="Nematode">nematode</a> model organism <a href="/wiki/Caenorhabditis_elegans" title="Caenorhabditis elegans">C. elegans</a> indicate that Notch signaling has a major role in the induction of mesoderm and cell fate determination.<a href="#cite_note-pmid3677168-12">[12]</a> As mentioned previously, C. elegans has two genes that encode for partially functionally redundant Notch homologs, glp-1 and lin-12.<a href="#cite_note-61">[61]</a> During C. elegans, GLP-1, the C. elegans Notch homolog, interacts with APX-1, the C. elegans Delta homolog. This signaling between particular blastomeres induces differentiation of cell fates and establishes the dorsal-ventral axis.<a href="#cite_note-62">[62]</a> <div class="mw-heading mw-heading3"><h3 id="Role_in_somitogenesis">Role in somitogenesis</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=9" title="Edit section: Role in somitogenesis">edit</a>]</div> Notch signaling is central to <a href="/wiki/Somitogenesis" title="Somitogenesis">somitogenesis</a>. In 1995, Notch1 was shown to be important for coordinating the segmentation of somites in mice.<a href="#cite_note-Conlon_RA,_Reaume_AG,_Rossant_J_1995_1533–45-63">[63]</a> Further studies identified the role of Notch signaling in the segmentation clock. These studies hypothesized that the primary function of Notch signaling does not act on an individual cell, but coordinates cell clocks and keep them synchronized. This hypothesis explained the role of Notch signaling in the development of segmentation and has been supported by experiments in mice and zebrafish.<a href="#cite_note-64">[64]</a><a href="#cite_note-65">[65]</a><a href="#cite_note-66">[66]</a> Experiments with Delta1 mutant mice that show abnormal somitogenesis with loss of anterior/posterior polarity suggest that Notch signaling is also necessary for the maintenance of somite borders.<a href="#cite_note-Conlon_RA,_Reaume_AG,_Rossant_J_1995_1533–45-63">[63]</a> During <a href="/wiki/Somitogenesis" title="Somitogenesis">somitogenesis</a>, a molecular oscillator in <a href="/wiki/Paraxial_mesoderm" title="Paraxial mesoderm">paraxial mesoderm</a> cells dictates the precise rate of somite formation. A <a href="/wiki/Clock_and_wavefront_model" title="Clock and wavefront model">clock and wavefront model</a> has been proposed in order to spatially determine the location and boundaries between <a href="/wiki/Somites" class="mw-redirect" title="Somites">somites</a>. This process is highly regulated as somites must have the correct size and spacing in order to avoid malformations within the axial skeleton that may potentially lead to <a href="/wiki/Spondylocostal_dysostosis" title="Spondylocostal dysostosis">spondylocostal dysostosis</a>. Several key components of the Notch signaling pathway help coordinate key steps in this process. In mice, mutations in Notch1, Dll1 or Dll3, Lfng, or Hes7 result in abnormal somite formation. Similarly, in humans, the following mutations have been seen to lead to development of spondylocostal dysostosis: DLL3, LFNG, or HES7.<a href="#cite_note-67">[67]</a> <div class="mw-heading mw-heading3"><h3 id="Role_in_epidermal_differentiation">Role in epidermal differentiation</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=10" title="Edit section: Role in epidermal differentiation">edit</a>]</div> Notch signaling is known to occur inside ciliated, differentiating cells found in the first epidermal layers during early skin development.<a href="#cite_note-68">[68]</a> Furthermore, it has found that <a href="/wiki/PSEN2" class="mw-redirect" title="PSEN2">presenilin-2</a> works in conjunction with ARF4 to regulate Notch signaling during this development.<a href="#cite_note-69">[69]</a> However, it remains to be determined whether gamma-secretase has a direct or indirect role in modulating Notch signaling. <div class="mw-heading mw-heading2"><h2 id="Role_in_central_nervous_system_development_and_function">Role in central nervous system development and function</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=11" title="Edit section: Role in central nervous system development and function">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Neuro-Gliogenesis_via_Lateral_Inhibition.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/Neuro-Gliogenesis_via_Lateral_Inhibition.png/220px-Neuro-Gliogenesis_via_Lateral_Inhibition.png" decoding="async" width="220" height="78" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/Neuro-Gliogenesis_via_Lateral_Inhibition.png/330px-Neuro-Gliogenesis_via_Lateral_Inhibition.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/09/Neuro-Gliogenesis_via_Lateral_Inhibition.png/440px-Neuro-Gliogenesis_via_Lateral_Inhibition.png 2x" data-file-width="7084" data-file-height="2501" /></a><figcaption>Notch-Delta lateral inhibition in neural stem cells, resulting in the generation of neuronal and glial progenitors.</figcaption></figure> Early findings on Notch signaling in <a href="/wiki/Central_nervous_system" title="Central nervous system">central nervous system</a> (CNS) development were performed mainly in <a href="/wiki/Drosophila" title="Drosophila">Drosophila</a> with <a href="/wiki/Mutagenesis" title="Mutagenesis">mutagenesis</a> experiments. For example, the finding that an embryonic lethal phenotype in Drosophila was associated with Notch dysfunction<a href="#cite_note-70">[70]</a> indicated that Notch mutations can lead to the failure of neural and <a href="/wiki/Epidermis_(zoology)" title="Epidermis (zoology)">Epidermal</a> cell segregation in early Drosophila embryos. In the past decade, advances in mutation and knockout techniques allowed research on the Notch signaling pathway in mammalian models, especially rodents. The Notch signaling pathway was found to be critical mainly for neural <a href="/wiki/Progenitor_cell" title="Progenitor cell">progenitor cell</a> (NPC) maintenance and self-renewal. In recent years, other functions of the Notch pathway have also been found, including <a href="/wiki/Glial_cell" class="mw-redirect" title="Glial cell">glial cell</a> specification,<a href="#cite_note-dada-71">[71]</a><a href="#cite_note-baba-72">[72]</a> <a href="/wiki/Neurites" class="mw-redirect" title="Neurites">neurites</a> development,<a href="#cite_note-neurite-73">[73]</a> as well as learning and memory.<a href="#cite_note-learning-74">[74]</a> <div class="mw-heading mw-heading3"><h3 id="Neuron_cell_differentiation">Neuron cell differentiation</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=12" title="Edit section: Neuron cell differentiation">edit</a>]</div> The Notch pathway is essential for maintaining NPCs in the developing brain. Activation of the pathway is sufficient to maintain NPCs in a proliferating state, whereas loss-of-function mutations in the critical components of the pathway cause precocious neuronal differentiation and NPC depletion.<a href="#cite_note-pmid17409286-45">[45]</a> Modulators of the Notch signal, e.g., the <a href="/wiki/NUMB_(gene)" title="NUMB (gene)">Numb</a> protein are able to antagonize Notch effects, resulting in the halting of cell cycle and the differentiation of NPCs.<a href="#cite_note-75">[75]</a><a href="#cite_note-76">[76]</a> Conversely, the <a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">fibroblast growth factor</a> pathway promotes Notch signaling to keep <a href="/wiki/Stem_cell" title="Stem cell">stem cells</a> of the <a href="/wiki/Cerebral_cortex" title="Cerebral cortex">cerebral cortex</a> in the proliferative state, amounting to a mechanism regulating cortical surface area growth and, potentially, <a href="/wiki/Gyrification" title="Gyrification">gyrification</a>.<a href="#cite_note-77">[77]</a><a href="#cite_note-78">[78]</a> In this way, Notch signaling controls NPC self-renewal as well as cell fate specification. A non-canonical branch of the Notch signaling pathway that involves the phosphorylation of STAT3 on the serine residue at amino acid position 727 and subsequent Hes3 expression increase (<a href="/wiki/Hes3_signaling_axis" title="Hes3 signaling axis">STAT3-Ser/Hes3 Signaling Axis</a>) has been shown to regulate the number of NPCs in culture and in the adult rodent brain.<a href="#cite_note-79">[79]</a> In adult rodents and in cell culture, Notch3 promotes neuronal differentiation, having a role opposite to Notch1/2.<a href="#cite_note-80">[80]</a> This indicates that individual Notch receptors can have divergent functions, depending on cellular context. <div class="mw-heading mw-heading3"><h3 id="Neurite_development">Neurite development</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=13" title="Edit section: Neurite development">edit</a>]</div> In vitro studies show that Notch can influence <a href="/wiki/Neurite" title="Neurite">neurite</a> development.<a href="#cite_note-neurite-73">[73]</a> In vivo, deletion of the Notch signaling modulator, Numb, disrupts neuronal maturation in the developing cerebellum,<a href="#cite_note-pmid14729486-81">[81]</a> whereas deletion of Numb disrupts axonal arborization in sensory ganglia.<a href="#cite_note-82">[82]</a> Although the mechanism underlying this phenomenon is not clear, together these findings suggest Notch signaling might be crucial in neuronal maturation. <div class="mw-heading mw-heading3"><h3 id="Gliogenesis">Gliogenesis</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=14" title="Edit section: Gliogenesis">edit</a>]</div> In <a href="/wiki/Gliogenesis" title="Gliogenesis">gliogenesis</a>, Notch appears to have an instructive role that can directly promote the differentiation of many <a href="/wiki/Glial_cell" class="mw-redirect" title="Glial cell">glial cell</a> subtypes.<a href="#cite_note-dada-71">[71]</a><a href="#cite_note-baba-72">[72]</a> For example, activation of Notch signaling in the retina favors the generation of <a href="/wiki/Muller_glia" class="mw-redirect" title="Muller glia">Muller glia</a> cells at the expense of neurons, whereas reduced Notch signaling induces production of ganglion cells, causing a reduction in the number of Muller glia.<a href="#cite_note-pmid17409286-45">[45]</a> <div class="mw-heading mw-heading3"><h3 id="Adult_brain_function">Adult brain function</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=15" title="Edit section: Adult brain function">edit</a>]</div> Apart from its role in development, evidence shows that Notch signaling is also involved in neuronal apoptosis, neurite retraction, and neurodegeneration of ischemic stroke in the brain<a href="#cite_note-83">[83]</a> In addition to developmental functions, Notch proteins and ligands are expressed in cells of the adult nervous system,<a href="#cite_note-84">[84]</a> suggesting a role in CNS plasticity throughout life. Adult mice heterozygous for mutations in either Notch1 or Cbf1 have deficits in spatial learning and memory.<a href="#cite_note-learning-74">[74]</a> Similar results are seen in experiments with <a href="/wiki/Presenilin" title="Presenilin">presenilins</a>1 and 2, which mediate the Notch intramembranous cleavage. To be specific, conditional deletion of presenilins at 3 weeks after birth in excitatory neurons causes learning and memory deficits, neuronal dysfunction, and gradual neurodegeneration.<a href="#cite_note-pmid15066262-85">[85]</a> Several <a href="/wiki/Gamma_secretase" title="Gamma secretase">gamma secretase</a> inhibitors that underwent human clinical trials in <a href="/wiki/Alzheimer%27s_disease" title="Alzheimer's disease">Alzheimer's disease</a> and <a href="/wiki/Mild_cognitive_impairment" title="Mild cognitive impairment">MCI</a> patients resulted in statistically significant worsening of cognition relative to controls, which is thought to be due to its incidental effect on Notch signalling.<a href="#cite_note-86">[86]</a> <div class="mw-heading mw-heading2"><h2 id="Role_in_cardiovascular_development">Role in cardiovascular development</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=16" title="Edit section: Role in cardiovascular development">edit</a>]</div> The Notch signaling pathway is a critical component of cardiovascular formation and <a href="/wiki/Morphogenesis" title="Morphogenesis">morphogenesis</a> in both development and disease. It is required for the selection of endothelial <a href="/wiki/Tip_cells" class="mw-redirect" title="Tip cells">tip</a> and <a href="/wiki/Stalk_cells" class="mw-redirect" title="Stalk cells">stalk cells</a> during <a href="/wiki/Sprouting_angiogenesis" class="mw-redirect" title="Sprouting angiogenesis">sprouting angiogenesis</a>.<a href="#cite_note-87">[87]</a> <div class="mw-heading mw-heading3"><h3 id="Cardiac_development">Cardiac development</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=17" title="Edit section: Cardiac development">edit</a>]</div> Notch signal pathway plays a crucial role in at least three cardiac development processes: <a href="/wiki/Atrioventricular_canal" title="Atrioventricular canal">Atrioventricular canal</a> development, <a href="/wiki/Myocardial_development" class="mw-redirect" title="Myocardial development">myocardial development</a>, and cardiac outflow tract (OFT) development.<a href="#cite_note-haha-88">[88]</a> <div class="mw-heading mw-heading4"><h4 id="Atrioventricular_(AV)_canal_development">Atrioventricular (AV) canal development</h4>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=18" title="Edit section: Atrioventricular (AV) canal development">edit</a>]</div> <dl><dt>AV boundary formation</dt> <dd>Notch signaling can regulate the atrioventricular boundary formation between the AV canal and the chamber myocardium. Studies have revealed that both loss- and gain-of-function of the Notch pathway results in defects in AV canal development.<a href="#cite_note-haha-88">[88]</a> In addition, the Notch target genes <a href="/wiki/HEY1" title="HEY1">HEY1</a> and <a href="/wiki/HEY2" title="HEY2">HEY2</a> are involved in restricting the expression of two critical developmental regulator proteins, BMP2 and Tbx2, to the AV canal.<a href="#cite_note-89">[89]</a><a href="#cite_note-90">[90]</a></dd></dl> <dl><dt>AV epithelial-mesenchymal transition (EMT)</dt> <dd>Notch signaling is also important for the process of AV <a href="/wiki/Epithelial-mesenchymal_transition" class="mw-redirect" title="Epithelial-mesenchymal transition">EMT</a>, which is required for AV canal maturation. After the AV canal boundary formation, a subset of endocardial cells lining the AV canal are activated by signals emanating from the <a href="/wiki/Myocardium" class="mw-redirect" title="Myocardium">myocardium</a> and by interendocardial signaling pathways to undergo EMT.<a href="#cite_note-haha-88">[88]</a> Notch1 deficiency results in defective induction of EMT. Very few migrating cells are seen and these lack mesenchymal morphology.<a href="#cite_note-ReferenceA-91">[91]</a> Notch may regulate this process by activating matrix <a href="/wiki/Metalloproteinase" title="Metalloproteinase">metalloproteinase</a>2 (MMP2) expression, or by inhibiting <a href="/wiki/VE-cadherin" title="VE-cadherin">vascular endothelial (VE)-cadherin</a> expression in the AV canal endocardium<a href="#cite_note-92">[92]</a> while suppressing the VEGF pathway via VEGFR2.<a href="#cite_note-93">[93]</a> In RBPJk/CBF1-targeted mutants, the heart valve development is severely disrupted, presumably because of defective endocardial maturation and signaling.<a href="#cite_note-ReferenceA-91">[91]</a></dd></dl> <div class="mw-heading mw-heading4"><h4 id="Ventricular_development">Ventricular development</h4>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=19" title="Edit section: Ventricular development">edit</a>]</div> Some studies in <a href="/wiki/Xenopus" title="Xenopus">Xenopus</a><a href="#cite_note-94">[94]</a> and in mouse embryonic stem cells<a href="#cite_note-95">[95]</a> indicate that cardiomyogenic commitment and differentiation require Notch signaling inhibition. Active Notch signaling is required in the ventricular <a href="/wiki/Endocardium" title="Endocardium">endocardium</a> for proper trabeculae development subsequent to myocardial specification by regulating <a href="/wiki/BMP10" class="mw-redirect" title="BMP10">BMP10</a>, <a href="/wiki/NRG1" class="mw-redirect" title="NRG1">NRG1</a>, and <a href="/wiki/Ephrin" title="Ephrin">Ephrin</a>B2 expression.<a href="#cite_note-Grego-Bessa_2007-49">[49]</a> Notch signaling sustains immature <a href="/wiki/Cardiomyocyte_proliferation" title="Cardiomyocyte proliferation">cardiomyocyte proliferation</a> in mammals <a href="#cite_note-96">[96]</a><a href="#cite_note-97">[97]</a><a href="#cite_note-98">[98]</a> and zebrafish.<a href="#cite_note-99">[99]</a> A regulatory correspondence likely exists between Notch signaling and <a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt signaling</a>, whereby upregulated Wnt expression downregulates Notch signaling, and a subsequent inhibition of ventricular cardiomyocyte proliferation results. This proliferative arrest can be rescued using Wnt inhibitors.<a href="#cite_note-100">[100]</a> The downstream effector of Notch signaling, HEY2, was also demonstrated to be important in regulating ventricular development by its expression in the interventricular <a href="/wiki/Septum" title="Septum">septum</a> and the endocardial cells of the <a href="/wiki/Atrioventricular_cushions" class="mw-redirect" title="Atrioventricular cushions">cardiac cushions</a>.<a href="#cite_note-101">[101]</a> Cardiomyocyte and smooth muscle cell-specific deletion of HEY2 results in impaired cardiac contractility, malformed right ventricle, and ventricular septal defects.<a href="#cite_note-102">[102]</a> <div class="mw-heading mw-heading4"><h4 id="Ventricular_outflow_tract_development">Ventricular outflow tract development</h4>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=20" title="Edit section: Ventricular outflow tract development">edit</a>]</div> During development of the aortic arch and the aortic arch arteries, the Notch receptors, ligands, and target genes display a unique expression pattern.<a href="#cite_note-103">[103]</a> When the Notch pathway was blocked, the induction of vascular <a href="/wiki/Smooth_muscle" title="Smooth muscle">smooth muscle</a> cell marker expression failed to occur, suggesting that Notch is involved in the differentiation of cardiac neural crest cells into vascular cells during outflow tract development. <div class="mw-heading mw-heading3"><h3 id="Angiogenesis">Angiogenesis</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=21" title="Edit section: Angiogenesis">edit</a>]</div> <a href="/wiki/Endothelial" class="mw-redirect" title="Endothelial">Endothelial</a> cells use the Notch signaling pathway to coordinate cellular behaviors during the blood vessel sprouting that occurs <a href="/wiki/Sprouting_angiogenesis" class="mw-redirect" title="Sprouting angiogenesis">sprouting angiogenesis</a>.<a href="#cite_note-104">[104]</a><a href="#cite_note-pmid17251261-105">[105]</a><a href="#cite_note-106">[106]</a><a href="#cite_note-pmid17259972-107">[107]</a> Activation of Notch takes place primarily in "connector" cells and cells that line patent stable blood vessels through direct interaction with the Notch ligand, <a href="/wiki/DLL4" title="DLL4">Delta-like ligand 4</a> (Dll4), which is expressed in the endothelial tip cells.<a href="#cite_note-Siekmann_2007-108">[108]</a> VEGF signaling, which is an important factor for migration and proliferation of endothelial cells,<a href="#cite_note-pmid11166270-109">[109]</a> can be downregulated in cells with activated Notch signaling by lowering the levels of Vegf receptor transcript.<a href="#cite_note-pmid16219802-110">[110]</a> Zebrafish embryos lacking Notch signaling exhibit ectopic and persistent expression of the zebrafish ortholog of VEGF3, flt4, within all endothelial cells, while Notch activation completely represses its expression.<a href="#cite_note-111">[111]</a> Notch signaling may be used to control the sprouting pattern of blood vessels during angiogenesis. When cells within a patent vessel are exposed to <a href="/wiki/VEGF" class="mw-redirect" title="VEGF">VEGF</a> signaling, only a restricted number of them initiate the angiogenic process. Vegf is able to induce <a href="/wiki/DLL4" title="DLL4">DLL4</a> expression. In turn, DLL4 expressing cells down-regulate Vegf receptors in neighboring cells through activation of Notch, thereby preventing their migration into the developing sprout. Likewise, during the sprouting process itself, the migratory behavior of connector cells must be limited to retain a patent connection to the original blood vessel.<a href="#cite_note-Siekmann_2007-108">[108]</a> <div class="mw-heading mw-heading2"><h2 id="Role_in_endocrine_development">Role in endocrine development</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=22" title="Edit section: Role in endocrine development">edit</a>]</div> During development, definitive <a href="/wiki/Endoderm" title="Endoderm">endoderm</a> and <a href="/wiki/Ectoderm" title="Ectoderm">ectoderm</a> differentiates into several gastrointestinal epithelial lineages, including endocrine cells. Many studies have indicated that Notch signaling has a major role in endocrine development. <div class="mw-heading mw-heading3"><h3 id="Pancreatic_development">Pancreatic development</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=23" title="Edit section: Pancreatic development">edit</a>]</div> The formation of the pancreas from endoderm begins in early development. The expression of elements of the Notch signaling pathway have been found in the developing pancreas, suggesting that Notch signaling is important in pancreatic development.<a href="#cite_note-pmid10476967-112">[112]</a><a href="#cite_note-pmid10842072-113">[113]</a> Evidence suggests Notch signaling regulates the progressive recruitment of endocrine cell types from a common precursor,<a href="#cite_note-pmid12941629-114">[114]</a> acting through two possible mechanisms. One is the "lateral inhibition", which specifies some cells for a primary fate but others for a secondary fate among cells that have the potential to adopt the same fate. Lateral inhibition is required for many types of cell fate determination. Here, it could explain the dispersed distribution of endocrine cells within pancreatic epithelium.<a href="#cite_note-pmid10615124-115">[115]</a> A second mechanism is "suppressive maintenance", which explains the role of Notch signaling in pancreas differentiation. Fibroblast growth factor10 is thought to be important in this activity, but the details are unclear.<a href="#cite_note-pmid14699589-116">[116]</a><a href="#cite_note-pmid14651921-117">[117]</a> <div class="mw-heading mw-heading3"><h3 id="Intestinal_development">Intestinal development</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=24" title="Edit section: Intestinal development">edit</a>]</div> The role of Notch signaling in the regulation of gut development has been indicated in several reports. Mutations in elements of the Notch signaling pathway affect the earliest intestinal cell fate decisions during zebrafish development.<a href="#cite_note-Crosnier_2005-118">[118]</a> Transcriptional analysis and gain of function experiments revealed that Notch signaling targets Hes1 in the intestine and regulates a binary cell fate decision between adsorptive and secretory cell fates.<a href="#cite_note-Crosnier_2005-118">[118]</a> <div class="mw-heading mw-heading3"><h3 id="Bone_development">Bone development</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=25" title="Edit section: Bone development">edit</a>]</div> Early in vitro studies have found the Notch signaling pathway functions as down-regulator in <a href="/wiki/Osteoclast" title="Osteoclast">osteoclastogenesis</a> and <a href="/wiki/Osteoblast" title="Osteoblast">osteoblastogenesis</a>.<a href="#cite_note-119">[119]</a> Notch1 is expressed in the mesenchymal condensation area and subsequently in the hypertrophic <a href="/wiki/Chondrocytes" class="mw-redirect" title="Chondrocytes">chondrocytes</a> during chondrogenesis.<a href="#cite_note-120">[120]</a> Overexpression of Notch signaling inhibits bone morphogenetic protein2-induced osteoblast differentiation. Overall, Notch signaling has a major role in the commitment of mesenchymal cells to the osteoblastic lineage and provides a possible therapeutic approach to bone regeneration.<a href="#cite_note-pmid15695512-53">[53]</a> <div class="mw-heading mw-heading2"><h2 id="Role_in_cancer">Role in cancer</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=26" title="Edit section: Role in cancer">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Leukemia">Leukemia</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=27" title="Edit section: Leukemia">edit</a>]</div> Aberrant Notch signaling is a driver of T cell acute lymphoblastic leukemia (T-ALL)<a href="#cite_note-121">[121]</a> and is mutated in at least 65% of all T-ALL cases.<a href="#cite_note-122">[122]</a> Notch signaling can be activated by mutations in Notch itself, inactivating mutations in <a href="/wiki/FBXW7" title="FBXW7">FBXW7</a> (a negative regulator of Notch1), or rarely by t(7;9)(q34;q34.3) translocation. In the context of T-ALL, Notch activity cooperates with additional oncogenic lesions such as <a href="/wiki/Myc" title="Myc">c-MYC</a> to activate anabolic pathways such as ribosome and protein biosynthesis thereby promoting leukemia cell growth.<a href="#cite_note-123">[123]</a> <div class="mw-heading mw-heading3"><h3 id="Urothelial_bladder_cancer">Urothelial bladder cancer</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=28" title="Edit section: Urothelial bladder cancer">edit</a>]</div> Loss of Notch activity is a driving event in urothelial cancer. A study identified inactivating mutations in components of the Notch pathway in over 40% of examined human bladder carcinomas. In mouse models, genetic inactivation of Notch signaling results in Erk1/2 phosphorylation leading to tumorigenesis in the urinary tract.<a href="#cite_note-124">[124]</a> As not all NOTCH receptors are equally involved in the urothelial bladder cancer, 90% of samples in one study had some level of NOTCH3 expression, suggesting that NOTCH3 plays an important role in urothelial bladder cancer. A higher level of NOTCH3 expression was observed in high-grade tumors, and a higher level of positivity was associated with a higher mortality risk. NOTCH3 was identified as an independent predictor of poor outcome. Therefore, it is suggested that NOTCH3 could be used as a marker for urothelial bladder cancer-specific mortality risk. It was also shown that NOTCH3 expression could be a prognostic immunohistochemical marker for clinical follow-up of urothelial bladder cancer patients, contributing to a more individualized approach by selecting patients to undergo control cystoscopy after a shorter time interval.<a href="#cite_note-125">[125]</a> <div class="mw-heading mw-heading3"><h3 id="Liver_cancer">Liver cancer</h3>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=29" title="Edit section: Liver cancer">edit</a>]</div> In <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">hepatocellular carcinoma</a>, for instance, it was suggesting that <a href="/wiki/AXIN1" title="AXIN1">AXIN1</a> mutations would provoke Notch signaling pathway activation, fostering the cancer development, but a recent study demonstrated that such an effect cannot be detected.<a href="#cite_note-126">[126]</a> Thus the exact role of Notch signaling in the cancer process awaits further elucidation. <div class="mw-heading mw-heading2"><h2 id="Notch_inhibitors">Notch inhibitors</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=30" title="Edit section: Notch inhibitors">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/DAPT_(chemical)" title="DAPT (chemical)">DAPT (chemical)</a></div> The involvement of Notch signaling in many cancers has led to investigation of <a href="/w/index.php?title=Notch_inhibitor&action=edit&redlink=1" class="new" title="Notch inhibitor (page does not exist)">notch inhibitors</a> (especially <a href="/w/index.php?title=Gamma-secretase_inhibitor&action=edit&redlink=1" class="new" title="Gamma-secretase inhibitor (page does not exist)">gamma-secretase inhibitors</a>) as cancer treatments which are in different phases of clinical trials.<a href="#cite_note-ReferenceB-2">[2]</a><a href="#cite_note-Purow2012-127">[127]</a> As of 2013<a class="external text" href="https://en.wikipedia.org/w/index.php?title=Notch_signaling_pathway&action=edit">[update]</a> at least 7 notch inhibitors were in clinical trials.<a href="#cite_note-EM2013-128">[128]</a> <a href="/w/index.php?title=MK-0752&action=edit&redlink=1" class="new" title="MK-0752 (page does not exist)">MK-0752</a> has given promising results in an early clinical trial for breast cancer.<a href="#cite_note-MK-129">[129]</a> Preclinical studies showed beneficial effects of <a href="/wiki/Gamma-secretase" class="mw-redirect" title="Gamma-secretase">gamma-secretase</a> inhibitors in <a href="/wiki/Endometriosis" title="Endometriosis">endometriosis</a>,<a href="#cite_note-130">[130]</a> a disease characterised by increased expression of notch pathway constituents.<a href="#cite_note-131">[131]</a><a href="#cite_note-132">[132]</a> Several notch inhibitors, including the gamma-secretase inhibitor <a href="/w/index.php?title=LY3056480&action=edit&redlink=1" class="new" title="LY3056480 (page does not exist)">LY3056480</a>, are being studied for their potential ability to regenerate <a href="/wiki/Hair_cell" title="Hair cell">hair cells</a> in the <a href="/wiki/Cochlea" title="Cochlea">cochlea</a>, which could lead to treatments for <a href="/wiki/Hearing_loss" title="Hearing loss">hearing loss</a> and <a href="/wiki/Tinnitus" title="Tinnitus">tinnitus</a>.<a href="#cite_note-Erni_2021-133">[133]</a><a href="#cite_note-Samarajeewa_2019-134">[134]</a> <div class="mw-heading mw-heading2"><h2 id="Mathematical_modeling">Mathematical modeling</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=31" title="Edit section: Mathematical modeling">edit</a>]</div> Mathematical modeling in Notch-Delta signaling has become a pivotal tool in understanding pattern formation driven by cell-cell interactions, particularly in the context of lateral-inhibition mechanisms. The Collier model,<a href="#cite_note-135">[135]</a> a cornerstone in this field, employs a system of coupled <a href="/wiki/Ordinary_differential_equation" title="Ordinary differential equation">ordinary differential equations</a> to describe the feedback loop between adjacent cells. The model is defined by the equations:<math display="block" xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\begin{aligned}{\frac {d}{dt}}n_{i}&=f(\langle d_{i}\rangle )-n_{i}\\{\frac {d}{dt}}d_{i}&=\nu (g(n_{i})-d_{i})\end{aligned}}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mrow class="MJX-TeXAtom-ORD"> <mtable columnalign="right left right left right left right left right left right left" rowspacing="3pt" columnspacing="0em 2em 0em 2em 0em 2em 0em 2em 0em 2em 0em" displaystyle="true"> <mtr> <mtd> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mi>d</mi> <mrow> <mi>d</mi> <mi>t</mi> </mrow> </mfrac> </mrow> <msub> <mi>n</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> </mtd> <mtd> <mi></mi> <mo>=</mo> <mi>f</mi> <mo stretchy="false">(</mo> <mo fence="false" stretchy="false">⟨</mo> <msub> <mi>d</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> <mo fence="false" stretchy="false">⟩</mo> <mo stretchy="false">)</mo> <mo>−</mo> <msub> <mi>n</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> </mtd> </mtr> <mtr> <mtd> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mi>d</mi> <mrow> <mi>d</mi> <mi>t</mi> </mrow> </mfrac> </mrow> <msub> <mi>d</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> </mtd> <mtd> <mi></mi> <mo>=</mo> <mi>ν</mi> <mo stretchy="false">(</mo> <mi>g</mi> <mo stretchy="false">(</mo> <msub> <mi>n</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> <mo stretchy="false">)</mo> <mo>−</mo> <msub> <mi>d</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> <mo stretchy="false">)</mo> </mtd> </mtr> </mtable> </mrow> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle {\begin{aligned}{\frac {d}{dt}}n_{i}&=f(\langle d_{i}\rangle )-n_{i}\\{\frac {d}{dt}}d_{i}&=\nu (g(n_{i})-d_{i})\end{aligned}}}</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/6c7641d64823ea3b8f1fc30bf47ff333f89017d1" class="mwe-math-fallback-image-display mw-invert skin-invert" aria-hidden="true" style="vertical-align: -4.64ex; margin-bottom: -0.198ex; width:21.946ex; height:10.843ex;" alt="{\displaystyle {\begin{aligned}{\frac {d}{dt}}n_{i}&=f(\langle d_{i}\rangle )-n_{i}\\{\frac {d}{dt}}d_{i}&=\nu (g(n_{i})-d_{i})\end{aligned}}}"> where <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle n_{i}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>n</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle n_{i}}</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/57f87f905ba5a4d8c691ccaecd65fc47bd007ba4" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:2.194ex; height:2.009ex;" alt="{\displaystyle n_{i}}"> and <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle d_{i}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>d</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle d_{i}}</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/abe3154db7d4f92fb42dd1f80f52f528c6312e4a" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:2.009ex; height:2.509ex;" alt="{\displaystyle d_{i}}"> represent the levels of <a href="/wiki/Notch_proteins" title="Notch proteins">Notch</a> and Delta activity in cell <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle i}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>i</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle i}</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/add78d8608ad86e54951b8c8bd6c8d8416533d20" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:0.802ex; height:2.176ex;" alt="{\displaystyle i}">, respectively. Functions <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle f}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>f</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle f}</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/132e57acb643253e7810ee9702d9581f159a1c61" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:1.279ex; height:2.509ex;" alt="{\displaystyle f}"> and <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle g}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>g</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle g}</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/d3556280e66fe2c0d0140df20935a6f057381d77" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.671ex; width:1.116ex; height:2.009ex;" alt="{\displaystyle g}"> are typically <a href="/wiki/Hill_equation_(biochemistry)" title="Hill equation (biochemistry)">Hill functions</a>, reflecting the regulatory dynamics of the signaling process. The term <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle \langle d_{i}\rangle }"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mo fence="false" stretchy="false">⟨</mo> <msub> <mi>d</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> <mo fence="false" stretchy="false">⟩</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle \langle d_{i}\rangle }</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/fa4d49dac5633502af0ee720c2a189e30fe532c2" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.838ex; width:3.818ex; height:2.843ex;" alt="{\displaystyle \langle d_{i}\rangle }"> denotes the average level of Delta activity in the cells adjacent to cell <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle i}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>i</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle i}</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/add78d8608ad86e54951b8c8bd6c8d8416533d20" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:0.802ex; height:2.176ex;" alt="{\displaystyle i}">, integrating <a href="/wiki/Juxtacrine_signalling" title="Juxtacrine signalling">juxtacrine signaling</a> effects. Recent extensions of this model incorporate long-range signaling, acknowledging the role of cell protrusions like <a href="/wiki/Filopodia" title="Filopodia">filopodia</a> (<a href="/wiki/Cytoneme" title="Cytoneme">cytonemes</a>) that reach non-neighboring cells.<a href="#cite_note-Berkemeier_2023-136">[136]</a><a href="#cite_note-137">[137]</a><a href="#cite_note-138">[138]</a><a href="#cite_note-139">[139]</a> One extended model, often referred to as the <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle \epsilon }"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>ϵ</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle \epsilon }</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/c3837cad72483d97bcdde49c85d3b7b859fb3fd2" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:0.944ex; height:1.676ex;" alt="{\displaystyle \epsilon }">-Collier model,<a href="#cite_note-Berkemeier_2023-136">[136]</a> introduces a weighting parameter <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle \epsilon \in [0,1]}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>ϵ</mi> <mo>∈</mo> <mo stretchy="false">[</mo> <mn>0</mn> <mo>,</mo> <mn>1</mn> <mo stretchy="false">]</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle \epsilon \in [0,1]}</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/2284041657a2d5f73d1fea4ac4af504d94382b5d" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.838ex; width:8.437ex; height:2.843ex;" alt="{\displaystyle \epsilon \in [0,1]}"> to balance juxtacrine and long-range signaling. The interaction term <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle \langle d_{i}\rangle }"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mo fence="false" stretchy="false">⟨</mo> <msub> <mi>d</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>i</mi> </mrow> </msub> <mo fence="false" stretchy="false">⟩</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle \langle d_{i}\rangle }</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/fa4d49dac5633502af0ee720c2a189e30fe532c2" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.838ex; width:3.818ex; height:2.843ex;" alt="{\displaystyle \langle d_{i}\rangle }"> is modified to include these protrusions, creating a more complex, non-local signaling network. This model is instrumental in exploring pattern formation robustness and biological pattern refinement, considering the stochastic nature of filopodia dynamics and intrinsic noise. The application of mathematical modeling in Notch-Delta signaling has been particularly illuminating in understanding the patterning of sensory organ precursors (SOPs) in the <a href="/wiki/Drosophila_melanogaster" title="Drosophila melanogaster">Drosophila</a>'s notum and <a href="/wiki/Imaginal_disc" title="Imaginal disc">wing margin</a>.<a href="#cite_note-140">[140]</a><a href="#cite_note-pmid27226324-141">[141]</a> The mathematical modeling of Notch-Delta signaling thus provides significant insights into lateral inhibition mechanisms and pattern formation in biological systems. It enhances the understanding of cell-cell interaction variations leading to diverse tissue structures, contributing to developmental biology and offering potential therapeutic pathways in diseases related to Notch-Delta dysregulation. <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=32" title="Edit section: See also">edit</a>]</div> <ul><li><a href="/wiki/Alagille_syndrome" title="Alagille syndrome">Alagille syndrome</a></li> <li><a href="/wiki/Netpath" class="mw-redirect" title="Netpath">Netpath</a> – A curated resource of signal transduction pathways in humans</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=33" title="Edit section: References">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-pmid10221902-1">^ <a href="#cite_ref-pmid10221902_1-0">a</a> <a href="#cite_ref-pmid10221902_1-1">b</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFArtavanis-TsakonasRandLake1999" class="citation journal cs1">Artavanis-Tsakonas S, Rand MD, Lake RJ (April 1999). "Notch signaling: cell fate control and signal integration in development". Science. 284 (5415): 770–776. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1999Sci...284..770A">1999Sci...284..770A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.284.5415.770">10.1126/science.284.5415.770</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10221902">10221902</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Notch+signaling%3A+cell+fate+control+and+signal+integration+in+development&rft.volume=284&rft.issue=5415&rft.pages=770-776&rft.date=1999-04&rft_id=info%3Apmid%2F10221902&rft_id=info%3Adoi%2F10.1126%2Fscience.284.5415.770&rft_id=info%3Abibcode%2F1999Sci...284..770A&rft.aulast=Artavanis-Tsakonas&rft.aufirst=S&rft.au=Rand%2C+MD&rft.au=Lake%2C+RJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-ReferenceB-2">^ <a href="#cite_ref-ReferenceB_2-0">a</a> <a href="#cite_ref-ReferenceB_2-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKumarJuillerat-JeanneretGolshayan2016" class="citation journal cs1">Kumar R, Juillerat-Jeanneret L, Golshayan D (September 2016). <a rel="nofollow" class="external text" href="https://figshare.com/articles/journal_contribution/7928825">"Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases"</a>. Journal of Medicinal Chemistry. 59 (17): 7719–7737. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Facs.jmedchem.5b01516">10.1021/acs.jmedchem.5b01516</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27045975">27045975</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:43654713">43654713</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Notch+Antagonists%3A+Potential+Modulators+of+Cancer+and+Inflammatory+Diseases&rft.volume=59&rft.issue=17&rft.pages=7719-7737&rft.date=2016-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A43654713%23id-name%3DS2CID&rft_id=info%3Apmid%2F27045975&rft_id=info%3Adoi%2F10.1021%2Facs.jmedchem.5b01516&rft.aulast=Kumar&rft.aufirst=R&rft.au=Juillerat-Jeanneret%2C+L&rft.au=Golshayan%2C+D&rft_id=https%3A%2F%2Ffigshare.com%2Farticles%2Fjournal_contribution%2F7928825&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid10882063-3"><a href="#cite_ref-pmid10882063_3-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBrouLogeatGuptaBessia2000" class="citation journal cs1">Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, et al. (February 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1097-2765%2800%2980417-7">"A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE"</a>. Molecular Cell. 5 (2): 207–216. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1097-2765%2800%2980417-7">10.1016/S1097-2765(00)80417-7</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10882063">10882063</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Cell&rft.atitle=A+novel+proteolytic+cleavage+involved+in+Notch+signaling%3A+the+role+of+the+disintegrin-metalloprotease+TACE&rft.volume=5&rft.issue=2&rft.pages=207-216&rft.date=2000-02&rft_id=info%3Adoi%2F10.1016%2FS1097-2765%2800%2980417-7&rft_id=info%3Apmid%2F10882063&rft.aulast=Brou&rft.aufirst=C&rft.au=Logeat%2C+F&rft.au=Gupta%2C+N&rft.au=Bessia%2C+C&rft.au=LeBail%2C+O&rft.au=Doedens%2C+JR&rft.au=Cumano%2C+A&rft.au=Roux%2C+P&rft.au=Black%2C+RA&rft.au=Isra%C3%ABl%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS1097-2765%252800%252980417-7&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid17404512-4"><a href="#cite_ref-pmid17404512_4-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSharmaDraheimKelliher2007" class="citation journal cs1">Sharma VM, Draheim KM, Kelliher MA (April 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcc.6.8.4134">"The Notch1/c-Myc pathway in T cell leukemia"</a>. Cell Cycle. 6 (8): 927–930. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcc.6.8.4134">10.4161/cc.6.8.4134</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17404512">17404512</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell+Cycle&rft.atitle=The+Notch1%2Fc-Myc+pathway+in+T+cell+leukemia&rft.volume=6&rft.issue=8&rft.pages=927-930&rft.date=2007-04&rft_id=info%3Adoi%2F10.4161%2Fcc.6.8.4134&rft_id=info%3Apmid%2F17404512&rft.aulast=Sharma&rft.aufirst=VM&rft.au=Draheim%2C+KM&rft.au=Kelliher%2C+MA&rft_id=https%3A%2F%2Fdoi.org%2F10.4161%252Fcc.6.8.4134&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-5"><a href="#cite_ref-5">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMoelleringCornejoDavisDel_Bianco2009" class="citation journal cs1">Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, et al. (November 2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951323">"Direct inhibition of the NOTCH transcription factor complex"</a>. Nature. 462 (7270): 182–188. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2009Natur.462..182M">2009Natur.462..182M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature08543">10.1038/nature08543</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951323">2951323</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19907488">19907488</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Direct+inhibition+of+the+NOTCH+transcription+factor+complex&rft.volume=462&rft.issue=7270&rft.pages=182-188&rft.date=2009-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2951323%23id-name%3DPMC&rft_id=info%3Apmid%2F19907488&rft_id=info%3Adoi%2F10.1038%2Fnature08543&rft_id=info%3Abibcode%2F2009Natur.462..182M&rft.aulast=Moellering&rft.aufirst=RE&rft.au=Cornejo%2C+M&rft.au=Davis%2C+TN&rft.au=Del+Bianco%2C+C&rft.au=Aster%2C+JC&rft.au=Blacklow%2C+SC&rft.au=Kung%2C+AL&rft.au=Gilliland%2C+DG&rft.au=Verdine%2C+GL&rft.au=Bradner%2C+JE&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2951323&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-6"><a href="#cite_ref-6">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAroraAnsari2009" class="citation journal cs1">Arora PS, Ansari AZ (November 2009). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F462171a">"Chemical biology: A Notch above other inhibitors"</a>. Nature. 462 (7270): 171–173. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2009Natur.462..171A">2009Natur.462..171A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F462171a">10.1038/462171a</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19907487">19907487</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:205050842">205050842</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Chemical+biology%3A+A+Notch+above+other+inhibitors&rft.volume=462&rft.issue=7270&rft.pages=171-173&rft.date=2009-11&rft_id=info%3Adoi%2F10.1038%2F462171a&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A205050842%23id-name%3DS2CID&rft_id=info%3Apmid%2F19907487&rft_id=info%3Abibcode%2F2009Natur.462..171A&rft.aulast=Arora&rft.aufirst=PS&rft.au=Ansari%2C+AZ&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252F462171a&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Morgan1917-7"><a href="#cite_ref-Morgan1917_7-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMorgan1917" class="citation journal cs1"><a href="/wiki/Thomas_Hunt_Morgan" title="Thomas Hunt Morgan">Morgan TH</a> (1917). <a rel="nofollow" class="external text" href="https://zenodo.org/record/1431357">"The theory of the gene"</a>. <a href="/wiki/The_American_Naturalist" title="The American Naturalist">The American Naturalist</a>. 51 (609): 513–544. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1086%2F279629">10.1086/279629</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:84050307">84050307</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Naturalist&rft.atitle=The+theory+of+the+gene&rft.volume=51&rft.issue=609&rft.pages=513-544&rft.date=1917&rft_id=info%3Adoi%2F10.1086%2F279629&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A84050307%23id-name%3DS2CID&rft.aulast=Morgan&rft.aufirst=TH&rft_id=https%3A%2F%2Fzenodo.org%2Frecord%2F1431357&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-8"><a href="#cite_ref-8">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMorgan1928" class="citation book cs1">Morgan TH (1928). <a rel="nofollow" class="external text" href="http://onlinebooks.library.upenn.edu/webbin/book/lookupid?key=olbp24097">The theory of the gene</a> (revised ed.). Yale University Press. pp. 77–81. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-8240-1384-4" title="Special:BookSources/978-0-8240-1384-4"><bdi>978-0-8240-1384-4</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+theory+of+the+gene&rft.pages=77-81&rft.edition=revised&rft.pub=Yale+University+Press&rft.date=1928&rft.isbn=978-0-8240-1384-4&rft.aulast=Morgan&rft.aufirst=TH&rft_id=http%3A%2F%2Fonlinebooks.library.upenn.edu%2Fwebbin%2Fbook%2Flookupid%3Fkey%3Dolbp24097&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid3935325-9"><a href="#cite_ref-pmid3935325_9-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWhartonJohansenXuArtavanis-Tsakonas1985" class="citation journal cs1">Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S (December 1985). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2885%2990229-6">"Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats"</a>. Cell. 43 (3 Pt 2): 567–581. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2885%2990229-6">10.1016/0092-8674(85)90229-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3935325">3935325</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Nucleotide+sequence+from+the+neurogenic+locus+notch+implies+a+gene+product+that+shares+homology+with+proteins+containing+EGF-like+repeats&rft.volume=43&rft.issue=3+Pt+2&rft.pages=567-581&rft.date=1985-12&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2885%2990229-6&rft_id=info%3Apmid%2F3935325&rft.aulast=Wharton&rft.aufirst=KA&rft.au=Johansen%2C+KM&rft.au=Xu%2C+T&rft.au=Artavanis-Tsakonas%2C+S&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252F0092-8674%252885%252990229-6&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid3097517-10"><a href="#cite_ref-pmid3097517_10-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKiddKelleyYoung1986" class="citation journal cs1">Kidd S, Kelley MR, Young MW (September 1986). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC367044">"Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors"</a>. Molecular and Cellular Biology. 6 (9): 3094–3108. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2Fmcb.6.9.3094">10.1128/mcb.6.9.3094</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC367044">367044</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3097517">3097517</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Sequence+of+the+notch+locus+of+Drosophila+melanogaster%3A+relationship+of+the+encoded+protein+to+mammalian+clotting+and+growth+factors&rft.volume=6&rft.issue=9&rft.pages=3094-3108&rft.date=1986-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC367044%23id-name%3DPMC&rft_id=info%3Apmid%2F3097517&rft_id=info%3Adoi%2F10.1128%2Fmcb.6.9.3094&rft.aulast=Kidd&rft.aufirst=S&rft.au=Kelley%2C+MR&rft.au=Young%2C+MW&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC367044&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-11"><a href="#cite_ref-11">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGreenwaldSternbergHorvitz1983" class="citation journal cs1">Greenwald IS, Sternberg PW, Horvitz HR (September 1983). "The lin-12 locus specifies cell fates in Caenorhabditis elegans". Cell. 34 (2): 435–444. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2883%2990377-x">10.1016/0092-8674(83)90377-x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/6616618">6616618</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:40668388">40668388</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=The+lin-12+locus+specifies+cell+fates+in+Caenorhabditis+elegans&rft.volume=34&rft.issue=2&rft.pages=435-444&rft.date=1983-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A40668388%23id-name%3DS2CID&rft_id=info%3Apmid%2F6616618&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2883%2990377-x&rft.aulast=Greenwald&rft.aufirst=IS&rft.au=Sternberg%2C+PW&rft.au=Horvitz%2C+HR&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid3677168-12">^ <a href="#cite_ref-pmid3677168_12-0">a</a> <a href="#cite_ref-pmid3677168_12-1">b</a> <a href="#cite_ref-pmid3677168_12-2">c</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAustinKimble1987" class="citation journal cs1">Austin J, Kimble J (November 1987). "glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans". Cell. 51 (4): 589–599. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2887%2990128-0">10.1016/0092-8674(87)90128-0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3677168">3677168</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:31484517">31484517</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=glp-1+is+required+in+the+germ+line+for+regulation+of+the+decision+between+mitosis+and+meiosis+in+C.+elegans&rft.volume=51&rft.issue=4&rft.pages=589-599&rft.date=1987-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A31484517%23id-name%3DS2CID&rft_id=info%3Apmid%2F3677168&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2887%2990128-0&rft.aulast=Austin&rft.aufirst=J&rft.au=Kimble%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID3677169-13"><a href="#cite_ref-PMID3677169_13-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPriessSchnabelSchnabel1987" class="citation journal cs1">Priess JR, Schnabel H, Schnabel R (November 1987). "The glp-1 locus and cellular interactions in early C. elegans embryos". Cell. 51 (4): 601–611. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2887%2990129-2">10.1016/0092-8674(87)90129-2</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3677169">3677169</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:6282210">6282210</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=The+glp-1+locus+and+cellular+interactions+in+early+C.+elegans+embryos&rft.volume=51&rft.issue=4&rft.pages=601-611&rft.date=1987-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A6282210%23id-name%3DS2CID&rft_id=info%3Apmid%2F3677169&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2887%2990129-2&rft.aulast=Priess&rft.aufirst=JR&rft.au=Schnabel%2C+H&rft.au=Schnabel%2C+R&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID3000611-14"><a href="#cite_ref-PMID3000611_14-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGreenwald1985" class="citation journal cs1">Greenwald I (December 1985). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2885%2990230-2">"lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor"</a>. Cell. 43 (3 Pt 2): 583–590. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2885%2990230-2">10.1016/0092-8674(85)90230-2</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3000611">3000611</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=lin-12%2C+a+nematode+homeotic+gene%2C+is+homologous+to+a+set+of+mammalian+proteins+that+includes+epidermal+growth+factor&rft.volume=43&rft.issue=3+Pt+2&rft.pages=583-590&rft.date=1985-12&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2885%2990230-2&rft_id=info%3Apmid%2F3000611&rft.aulast=Greenwald&rft.aufirst=I&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252F0092-8674%252885%252990230-2&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid11604511-15"><a href="#cite_ref-pmid11604511_15-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOswaldTäuberDobnerBourteele2001" class="citation journal cs1">Oswald F, Täuber B, Dobner T, Bourteele S, Kostezka U, Adler G, et al. (November 2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99946">"p300 acts as a transcriptional coactivator for mammalian Notch-1"</a>. Molecular and Cellular Biology. 21 (22): 7761–7774. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.21.22.7761-7774.2001">10.1128/MCB.21.22.7761-7774.2001</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99946">99946</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11604511">11604511</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=p300+acts+as+a+transcriptional+coactivator+for+mammalian+Notch-1&rft.volume=21&rft.issue=22&rft.pages=7761-7774&rft.date=2001-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC99946%23id-name%3DPMC&rft_id=info%3Apmid%2F11604511&rft_id=info%3Adoi%2F10.1128%2FMCB.21.22.7761-7774.2001&rft.aulast=Oswald&rft.aufirst=F&rft.au=T%C3%A4uber%2C+B&rft.au=Dobner%2C+T&rft.au=Bourteele%2C+S&rft.au=Kostezka%2C+U&rft.au=Adler%2C+G&rft.au=Liptay%2C+S&rft.au=Schmid%2C+RM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC99946&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID8406001-16"><a href="#cite_ref-PMID8406001_16-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLieberKiddAlcamoCorbin1993" class="citation journal cs1">Lieber T, Kidd S, Alcamo E, Corbin V, Young MW (October 1993). <a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.7.10.1949">"Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei"</a>. Genes & Development. 7 (10): 1949–1965. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.7.10.1949">10.1101/gad.7.10.1949</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8406001">8406001</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Antineurogenic+phenotypes+induced+by+truncated+Notch+proteins+indicate+a+role+in+signal+transduction+and+may+point+to+a+novel+function+for+Notch+in+nuclei&rft.volume=7&rft.issue=10&rft.pages=1949-1965&rft.date=1993-10&rft_id=info%3Adoi%2F10.1101%2Fgad.7.10.1949&rft_id=info%3Apmid%2F8406001&rft.aulast=Lieber&rft.aufirst=T&rft.au=Kidd%2C+S&rft.au=Alcamo%2C+E&rft.au=Corbin%2C+V&rft.au=Young%2C+MW&rft_id=https%3A%2F%2Fdoi.org%2F10.1101%252Fgad.7.10.1949&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID8343960-17"><a href="#cite_ref-PMID8343960_17-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStruhlFitzgeraldGreenwald1993" class="citation journal cs1">Struhl G, Fitzgerald K, Greenwald I (July 1993). "Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo". Cell. 74 (2): 331–345. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2893%2990424-O">10.1016/0092-8674(93)90424-O</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8343960">8343960</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:27966283">27966283</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Intrinsic+activity+of+the+Lin-12+and+Notch+intracellular+domains+in+vivo&rft.volume=74&rft.issue=2&rft.pages=331-345&rft.date=1993-07&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A27966283%23id-name%3DS2CID&rft_id=info%3Apmid%2F8343960&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2893%2990424-O&rft.aulast=Struhl&rft.aufirst=G&rft.au=Fitzgerald%2C+K&rft.au=Greenwald%2C+I&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID1831692-18"><a href="#cite_ref-PMID1831692_18-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEllisenBirdWestSoreng1991" class="citation journal cs1">Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J (August 1991). "TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms". Cell. 66 (4): 649–661. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2891%2990111-B">10.1016/0092-8674(91)90111-B</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1831692">1831692</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:45604279">45604279</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=TAN-1%2C+the+human+homolog+of+the+Drosophila+notch+gene%2C+is+broken+by+chromosomal+translocations+in+T+lymphoblastic+neoplasms&rft.volume=66&rft.issue=4&rft.pages=649-661&rft.date=1991-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A45604279%23id-name%3DS2CID&rft_id=info%3Apmid%2F1831692&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2891%2990111-B&rft.aulast=Ellisen&rft.aufirst=LW&rft.au=Bird%2C+J&rft.au=West%2C+DC&rft.au=Soreng%2C+AL&rft.au=Reynolds%2C+TC&rft.au=Smith%2C+SD&rft.au=Sklar%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID9604939-19"><a href="#cite_ref-PMID9604939_19-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStruhlAdachi1998" class="citation journal cs1">Struhl G, Adachi A (May 1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2981193-9">"Nuclear access and action of notch in vivo"</a>. Cell. 93 (4): 649–660. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2981193-9">10.1016/S0092-8674(00)81193-9</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9604939">9604939</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:10828910">10828910</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Nuclear+access+and+action+of+notch+in+vivo&rft.volume=93&rft.issue=4&rft.pages=649-660&rft.date=1998-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A10828910%23id-name%3DS2CID&rft_id=info%3Apmid%2F9604939&rft_id=info%3Adoi%2F10.1016%2FS0092-8674%2800%2981193-9&rft.aulast=Struhl&rft.aufirst=G&rft.au=Adachi%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0092-8674%252800%252981193-9&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID9620803-20"><a href="#cite_ref-PMID9620803_20-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchroeterKisslingerKopan1998" class="citation journal cs1">Schroeter EH, Kisslinger JA, Kopan R (May 1998). "Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain". Nature. 393 (6683): 382–386. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1998Natur.393..382S">1998Natur.393..382S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F30756">10.1038/30756</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9620803">9620803</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4431882">4431882</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Notch-1+signalling+requires+ligand-induced+proteolytic+release+of+intracellular+domain&rft.volume=393&rft.issue=6683&rft.pages=382-386&rft.date=1998-05&rft_id=info%3Adoi%2F10.1038%2F30756&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4431882%23id-name%3DS2CID&rft_id=info%3Apmid%2F9620803&rft_id=info%3Abibcode%2F1998Natur.393..382S&rft.aulast=Schroeter&rft.aufirst=EH&rft.au=Kisslinger%2C+JA&rft.au=Kopan%2C+R&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID22785620-21">^ <a href="#cite_ref-PMID22785620_21-0">a</a> <a href="#cite_ref-PMID22785620_21-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGreenwald2012" class="citation journal cs1">Greenwald I (July 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389966">"Notch and the awesome power of genetics"</a>. Genetics. 191 (3): 655–669. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1534%2Fgenetics.112.141812">10.1534/genetics.112.141812</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389966">3389966</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22785620">22785620</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Notch+and+the+awesome+power+of+genetics&rft.volume=191&rft.issue=3&rft.pages=655-669&rft.date=2012-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3389966%23id-name%3DPMC&rft_id=info%3Apmid%2F22785620&rft_id=info%3Adoi%2F10.1534%2Fgenetics.112.141812&rft.aulast=Greenwald&rft.aufirst=I&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3389966&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID11134525-22"><a href="#cite_ref-PMID11134525_22-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStruhlGreenwald2001" class="citation journal cs1">Struhl G, Greenwald I (January 2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC14573">"Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila"</a>. Proceedings of the National Academy of Sciences of the United States of America. 98 (1): 229–234. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2001PNAS...98..229S">2001PNAS...98..229S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.98.1.229">10.1073/pnas.98.1.229</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC14573">14573</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11134525">11134525</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Presenilin-mediated+transmembrane+cleavage+is+required+for+Notch+signal+transduction+in+Drosophila&rft.volume=98&rft.issue=1&rft.pages=229-234&rft.date=2001-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC14573%23id-name%3DPMC&rft_id=info%3Apmid%2F11134525&rft_id=info%3Adoi%2F10.1073%2Fpnas.98.1.229&rft_id=info%3Abibcode%2F2001PNAS...98..229S&rft.aulast=Struhl&rft.aufirst=G&rft.au=Greenwald%2C+I&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC14573&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid7716513-23"><a href="#cite_ref-pmid7716513_23-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFArtavanis-TsakonasMatsunoFortini1995" class="citation journal cs1">Artavanis-Tsakonas S, Matsuno K, Fortini ME (April 1995). "Notch signaling". Science. 268 (5208): 225–232. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1995Sci...268..225A">1995Sci...268..225A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.7716513">10.1126/science.7716513</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7716513">7716513</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Notch+signaling&rft.volume=268&rft.issue=5208&rft.pages=225-232&rft.date=1995-04&rft_id=info%3Apmid%2F7716513&rft_id=info%3Adoi%2F10.1126%2Fscience.7716513&rft_id=info%3Abibcode%2F1995Sci...268..225A&rft.aulast=Artavanis-Tsakonas&rft.aufirst=S&rft.au=Matsuno%2C+K&rft.au=Fortini%2C+ME&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid9546393-24"><a href="#cite_ref-pmid9546393_24-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSingsonMercerL'Hernault1998" class="citation journal cs1">Singson A, Mercer KB, L'Hernault SW (April 1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2981147-2">"The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization"</a>. Cell. 93 (1): 71–79. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2981147-2">10.1016/S0092-8674(00)81147-2</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9546393">9546393</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:17455442">17455442</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=The+C.+elegans+spe-9+gene+encodes+a+sperm+transmembrane+protein+that+contains+EGF-like+repeats+and+is+required+for+fertilization&rft.volume=93&rft.issue=1&rft.pages=71-79&rft.date=1998-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A17455442%23id-name%3DS2CID&rft_id=info%3Apmid%2F9546393&rft_id=info%3Adoi%2F10.1016%2FS0092-8674%2800%2981147-2&rft.aulast=Singson&rft.aufirst=A&rft.au=Mercer%2C+KB&rft.au=L%27Hernault%2C+SW&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0092-8674%252800%252981147-2&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID16530044-25"><a href="#cite_ref-PMID16530044_25-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNamSlizSongAster2006" class="citation journal cs1">Nam Y, Sliz P, Song L, Aster JC, <a href="/w/index.php?title=Stephen_Blacklow&action=edit&redlink=1" class="new" title="Stephen Blacklow (page does not exist)">Blacklow SC</a> (March 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2005.12.037">"Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes"</a>. Cell. 124 (5): 973–983. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2005.12.037">10.1016/j.cell.2005.12.037</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16530044">16530044</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:17809522">17809522</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Structural+basis+for+cooperativity+in+recruitment+of+MAML+coactivators+to+Notch+transcription+complexes&rft.volume=124&rft.issue=5&rft.pages=973-983&rft.date=2006-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A17809522%23id-name%3DS2CID&rft_id=info%3Apmid%2F16530044&rft_id=info%3Adoi%2F10.1016%2Fj.cell.2005.12.037&rft.aulast=Nam&rft.aufirst=Y&rft.au=Sliz%2C+P&rft.au=Song%2C+L&rft.au=Aster%2C+JC&rft.au=Blacklow%2C+SC&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.cell.2005.12.037&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-PMID16530045-26"><a href="#cite_ref-PMID16530045_26-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWilsonKovall2006" class="citation journal cs1">Wilson JJ, Kovall RA (March 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2006.01.035">"Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA"</a>. Cell. 124 (5): 985–996. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2006.01.035">10.1016/j.cell.2006.01.035</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16530045">16530045</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9224353">9224353</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Crystal+structure+of+the+CSL-Notch-Mastermind+ternary+complex+bound+to+DNA&rft.volume=124&rft.issue=5&rft.pages=985-996&rft.date=2006-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A9224353%23id-name%3DS2CID&rft_id=info%3Apmid%2F16530045&rft_id=info%3Adoi%2F10.1016%2Fj.cell.2006.01.035&rft.aulast=Wilson&rft.aufirst=JJ&rft.au=Kovall%2C+RA&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.cell.2006.01.035&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid10899003-27"><a href="#cite_ref-pmid10899003_27-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMunroFreeman2000" class="citation journal cs1">Munro S, Freeman M (July 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0960-9822%2800%2900578-9">"The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD"</a>. Current Biology. 10 (14): 813–820. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2000CBio...10..813M">2000CBio...10..813M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0960-9822%2800%2900578-9">10.1016/S0960-9822(00)00578-9</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10899003">10899003</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:13909969">13909969</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=The+notch+signalling+regulator+fringe+acts+in+the+Golgi+apparatus+and+requires+the+glycosyltransferase+signature+motif+DXD&rft.volume=10&rft.issue=14&rft.pages=813-820&rft.date=2000-07&rft_id=info%3Adoi%2F10.1016%2FS0960-9822%2800%2900578-9&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A13909969%23id-name%3DS2CID&rft_id=info%3Apmid%2F10899003&rft_id=info%3Abibcode%2F2000CBio...10..813M&rft.aulast=Munro&rft.aufirst=S&rft.au=Freeman%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0960-9822%252800%252900578-9&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Lai-28">^ <a href="#cite_ref-Lai_28-0">a</a> <a href="#cite_ref-Lai_28-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLai2004" class="citation journal cs1">Lai EC (March 2004). "Notch signaling: control of cell communication and cell fate". Development. 131 (5): 965–973. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.01074">10.1242/dev.01074</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14973298">14973298</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:6930563">6930563</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Notch+signaling%3A+control+of+cell+communication+and+cell+fate&rft.volume=131&rft.issue=5&rft.pages=965-973&rft.date=2004-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A6930563%23id-name%3DS2CID&rft_id=info%3Apmid%2F14973298&rft_id=info%3Adoi%2F10.1242%2Fdev.01074&rft.aulast=Lai&rft.aufirst=EC&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid16973733-29"><a href="#cite_ref-pmid16973733_29-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMaSimala-GrantTaylor2006" class="citation journal cs1">Ma B, Simala-Grant JL, Taylor DE (December 2006). "Fucosylation in prokaryotes and eukaryotes". Glycobiology. 16 (12): 158R–184R. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fglycob%2Fcwl040">10.1093/glycob/cwl040</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16973733">16973733</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Glycobiology&rft.atitle=Fucosylation+in+prokaryotes+and+eukaryotes&rft.volume=16&rft.issue=12&rft.pages=158R-184R&rft.date=2006-12&rft_id=info%3Adoi%2F10.1093%2Fglycob%2Fcwl040&rft_id=info%3Apmid%2F16973733&rft.aulast=Ma&rft.aufirst=B&rft.au=Simala-Grant%2C+JL&rft.au=Taylor%2C+DE&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid12460944-30"><a href="#cite_ref-pmid12460944_30-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFShaoLuoMoloneyHaltiwanger2002" class="citation journal cs1">Shao L, Luo Y, Moloney DJ, Haltiwanger R (November 2002). "O-glycosylation of EGF repeats: identification and initial characterization of a UDP-glucose: protein O-glucosyltransferase". Glycobiology. 12 (11): 763–770. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fglycob%2Fcwf085">10.1093/glycob/cwf085</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12460944">12460944</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Glycobiology&rft.atitle=O-glycosylation+of+EGF+repeats%3A+identification+and+initial+characterization+of+a+UDP-glucose%3A+protein+O-glucosyltransferase&rft.volume=12&rft.issue=11&rft.pages=763-770&rft.date=2002-11&rft_id=info%3Adoi%2F10.1093%2Fglycob%2Fcwf085&rft_id=info%3Apmid%2F12460944&rft.aulast=Shao&rft.aufirst=L&rft.au=Luo%2C+Y&rft.au=Moloney%2C+DJ&rft.au=Haltiwanger%2C+R&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid17132502-31"><a href="#cite_ref-pmid17132502_31-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLuStanley2006" class="citation book cs1">Lu L, Stanley P (2006). "Roles of O-Fucose Glycans in Notch Signaling Revealed by Mutant Mice". Functional Glycomics. Methods in Enzymology. Vol. 417. pp. 127–136. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0076-6879%2806%2917010-X">10.1016/S0076-6879(06)17010-X</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780121828226" title="Special:BookSources/9780121828226"><bdi>9780121828226</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17132502">17132502</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Roles+of+O-Fucose+Glycans+in+Notch+Signaling+Revealed+by+Mutant+Mice&rft.btitle=Functional+Glycomics&rft.series=Methods+in+Enzymology&rft.pages=127-136&rft.date=2006&rft_id=info%3Apmid%2F17132502&rft_id=info%3Adoi%2F10.1016%2FS0076-6879%2806%2917010-X&rft.isbn=9780121828226&rft.aulast=Lu&rft.aufirst=L&rft.au=Stanley%2C+P&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid17215308-32"><a href="#cite_ref-pmid17215308_32-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFThomasvan_Meyel2007" class="citation journal cs1">Thomas GB, van Meyel DJ (February 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.02754">"The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression"</a>. Development. 134 (3): 591–600. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.02754">10.1242/dev.02754</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17215308">17215308</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=The+glycosyltransferase+Fringe+promotes+Delta-Notch+signaling+between+neurons+and+glia%2C+and+is+required+for+subtype-specific+glial+gene+expression&rft.volume=134&rft.issue=3&rft.pages=591-600&rft.date=2007-02&rft_id=info%3Adoi%2F10.1242%2Fdev.02754&rft_id=info%3Apmid%2F17215308&rft.aulast=Thomas&rft.aufirst=GB&rft.au=van+Meyel%2C+DJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fdev.02754&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid12826675-33"><a href="#cite_ref-pmid12826675_33-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLaVoieSelkoe2003" class="citation journal cs1">LaVoie MJ, Selkoe DJ (September 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M302659200">"The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments"</a>. The Journal of Biological Chemistry. 278 (36): 34427–34437. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M302659200">10.1074/jbc.M302659200</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12826675">12826675</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=The+Notch+ligands%2C+Jagged+and+Delta%2C+are+sequentially+processed+by+alpha-secretase+and+presenilin%2Fgamma-secretase+and+release+signaling+fragments&rft.volume=278&rft.issue=36&rft.pages=34427-34437&rft.date=2003-09&rft_id=info%3Adoi%2F10.1074%2Fjbc.M302659200&rft_id=info%3Apmid%2F12826675&rft.aulast=LaVoie&rft.aufirst=MJ&rft.au=Selkoe%2C+DJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M302659200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid19726682-34"><a href="#cite_ref-pmid19726682_34-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFvan_Teteringvan_DiestVerlaanvan_der_Wall2009" class="citation journal cs1">van Tetering G, van Diest P, Verlaan I, van der Wall E, Kopan R, Vooijs M (November 2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781502">"Metalloprotease ADAM10 is required for Notch1 site 2 cleavage"</a>. The Journal of Biological Chemistry. 284 (45): 31018–31027. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M109.006775">10.1074/jbc.M109.006775</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781502">2781502</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19726682">19726682</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Metalloprotease+ADAM10+is+required+for+Notch1+site+2+cleavage&rft.volume=284&rft.issue=45&rft.pages=31018-31027&rft.date=2009-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2781502%23id-name%3DPMC&rft_id=info%3Apmid%2F19726682&rft_id=info%3Adoi%2F10.1074%2Fjbc.M109.006775&rft.aulast=van+Tetering&rft.aufirst=G&rft.au=van+Diest%2C+P&rft.au=Verlaan%2C+I&rft.au=van+der+Wall%2C+E&rft.au=Kopan%2C+R&rft.au=Vooijs%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2781502&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-35"><a href="#cite_ref-35">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDesbordesLópez-Schier2006" class="citation book cs1">Desbordes S, López-Schier H (2006). "Drosophila Patterning: Delta-Notch Interactions". Encyclopedia of Life Sciences. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnpg.els.0004194">10.1038/npg.els.0004194</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/0470016175" title="Special:BookSources/0470016175"><bdi>0470016175</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Drosophila+Patterning%3A+Delta-Notch+Interactions&rft.btitle=Encyclopedia+of+Life+Sciences&rft.date=2006&rft_id=info%3Adoi%2F10.1038%2Fnpg.els.0004194&rft.isbn=0470016175&rft.aulast=Desbordes&rft.aufirst=S&rft.au=L%C3%B3pez-Schier%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid22223095-36"><a href="#cite_ref-pmid22223095_36-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBorggrefeLiefke2012" class="citation journal cs1">Borggrefe T, Liefke R (January 2012). <a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcc.11.2.18995">"Fine-tuning of the intracellular canonical Notch signaling pathway"</a>. Cell Cycle. 11 (2): 264–276. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcc.11.2.18995">10.4161/cc.11.2.18995</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22223095">22223095</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell+Cycle&rft.atitle=Fine-tuning+of+the+intracellular+canonical+Notch+signaling+pathway&rft.volume=11&rft.issue=2&rft.pages=264-276&rft.date=2012-01&rft_id=info%3Adoi%2F10.4161%2Fcc.11.2.18995&rft_id=info%3Apmid%2F22223095&rft.aulast=Borggrefe&rft.aufirst=T&rft.au=Liefke%2C+R&rft_id=https%3A%2F%2Fdoi.org%2F10.4161%252Fcc.11.2.18995&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-37"><a href="#cite_ref-37">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRebayFlemingFehonCherbas1991" class="citation journal cs1">Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S (November 1991). "Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor". Cell. 67 (4): 687–699. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2891%2990064-6">10.1016/0092-8674(91)90064-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1657403">1657403</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:12643727">12643727</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Specific+EGF+repeats+of+Notch+mediate+interactions+with+Delta+and+Serrate%3A+implications+for+Notch+as+a+multifunctional+receptor&rft.volume=67&rft.issue=4&rft.pages=687-699&rft.date=1991-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A12643727%23id-name%3DS2CID&rft_id=info%3Apmid%2F1657403&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2891%2990064-6&rft.aulast=Rebay&rft.aufirst=I&rft.au=Fleming%2C+RJ&rft.au=Fehon%2C+RG&rft.au=Cherbas%2C+L&rft.au=Cherbas%2C+P&rft.au=Artavanis-Tsakonas%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-38"><a href="#cite_ref-38">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRebayFlemingFehonCherbas1991" class="citation journal cs1">Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S (November 1991). "Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor". Cell. 67 (4): 687–699. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2012Sci...338.1229Y">2012Sci...338.1229Y</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0092-8674%2891%2990064-6">10.1016/0092-8674(91)90064-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1657403">1657403</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:12643727">12643727</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Specific+EGF+repeats+of+Notch+mediate+interactions+with+Delta+and+Serrate%3A+implications+for+Notch+as+a+multifunctional+receptor&rft.volume=67&rft.issue=4&rft.pages=687-699&rft.date=1991-11&rft_id=info%3Adoi%2F10.1016%2F0092-8674%2891%2990064-6&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A12643727%23id-name%3DS2CID&rft_id=info%3Apmid%2F1657403&rft_id=info%3Abibcode%2F2012Sci...338.1229Y&rft.aulast=Rebay&rft.aufirst=I&rft.au=Fleming%2C+RJ&rft.au=Fehon%2C+RG&rft.au=Cherbas%2C+L&rft.au=Cherbas%2C+P&rft.au=Artavanis-Tsakonas%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-39"><a href="#cite_ref-39">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation journal cs1">"Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1". Journal of Biological Chemistry. 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Intrinsic+selectivity+of+Notch+1+for+Delta-like+4+over+Delta-like+1&rft.date=2013&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Luca_2015-40">^ <a href="#cite_ref-Luca_2015_40-0">a</a> <a href="#cite_ref-Luca_2015_40-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLucaJudePierceNachury2015" class="citation journal cs1">Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC (February 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445638">"Structural biology. Structural basis for Notch1 engagement of Delta-like 4"</a>. Science. 347 (6224): 847–853. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2015Sci...347..847L">2015Sci...347..847L</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.1261093">10.1126/science.1261093</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445638">4445638</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25700513">25700513</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Structural+biology.+Structural+basis+for+Notch1+engagement+of+Delta-like+4&rft.volume=347&rft.issue=6224&rft.pages=847-853&rft.date=2015-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4445638%23id-name%3DPMC&rft_id=info%3Apmid%2F25700513&rft_id=info%3Adoi%2F10.1126%2Fscience.1261093&rft_id=info%3Abibcode%2F2015Sci...347..847L&rft.aulast=Luca&rft.aufirst=VC&rft.au=Jude%2C+KM&rft.au=Pierce%2C+NW&rft.au=Nachury%2C+MV&rft.au=Fischer%2C+S&rft.au=Garcia%2C+KC&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4445638&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Harmansa-41"><a href="#cite_ref-Harmansa_41-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHarmansaAffolter2018" class="citation journal cs1">Harmansa S, Affolter M (January 2018). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.148874">"Protein binders and their applications in developmental biology"</a>. Development. 145 (2): dev148874. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.148874">10.1242/dev.148874</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29374062">29374062</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Protein+binders+and+their+applications+in+developmental+biology&rft.volume=145&rft.issue=2&rft.pages=dev148874&rft.date=2018-01&rft_id=info%3Adoi%2F10.1242%2Fdev.148874&rft_id=info%3Apmid%2F29374062&rft.aulast=Harmansa&rft.aufirst=S&rft.au=Affolter%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fdev.148874&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-42"><a href="#cite_ref-42">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFThemeliSadelain2016" class="citation journal cs1">Themeli M, Sadelain M (April 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994806">"Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response"</a>. Trends in Molecular Medicine. 22 (4): 271–273. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.molmed.2016.02.009">10.1016/j.molmed.2016.02.009</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994806">4994806</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26971630">26971630</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Trends+in+Molecular+Medicine&rft.atitle=Combinatorial+Antigen+Targeting%3A+Ideal+T-Cell+Sensing+and+Anti-Tumor+Response&rft.volume=22&rft.issue=4&rft.pages=271-273&rft.date=2016-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4994806%23id-name%3DPMC&rft_id=info%3Apmid%2F26971630&rft_id=info%3Adoi%2F10.1016%2Fj.molmed.2016.02.009&rft.aulast=Themeli&rft.aufirst=M&rft.au=Sadelain%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4994806&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-43"><a href="#cite_ref-43">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSadelain2016" class="citation journal cs1">Sadelain M (August 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520666">"Chimeric antigen receptors: driving immunology towards synthetic biology"</a>. Current Opinion in Immunology. 41: 68–76. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.coi.2016.06.004">10.1016/j.coi.2016.06.004</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520666">5520666</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27372731">27372731</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Opinion+in+Immunology&rft.atitle=Chimeric+antigen+receptors%3A+driving+immunology+towards+synthetic+biology&rft.volume=41&rft.pages=68-76&rft.date=2016-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5520666%23id-name%3DPMC&rft_id=info%3Apmid%2F27372731&rft_id=info%3Adoi%2F10.1016%2Fj.coi.2016.06.004&rft.aulast=Sadelain&rft.aufirst=M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5520666&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid12052917-44"><a href="#cite_ref-pmid12052917_44-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGaianoFishell2002" class="citation journal cs1">Gaiano N, Fishell G (2002). "The role of notch in promoting glial and neural stem cell fates". Annual Review of Neuroscience. 25 (1): 471–490. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1146%2Fannurev.neuro.25.030702.130823">10.1146/annurev.neuro.25.030702.130823</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12052917">12052917</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Annual+Review+of+Neuroscience&rft.atitle=The+role+of+notch+in+promoting+glial+and+neural+stem+cell+fates&rft.volume=25&rft.issue=1&rft.pages=471-490&rft.date=2002&rft_id=info%3Adoi%2F10.1146%2Fannurev.neuro.25.030702.130823&rft_id=info%3Apmid%2F12052917&rft.aulast=Gaiano&rft.aufirst=N&rft.au=Fishell%2C+G&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid17409286-45">^ <a href="#cite_ref-pmid17409286_45-0">a</a> <a href="#cite_ref-pmid17409286_45-1">b</a> <a href="#cite_ref-pmid17409286_45-2">c</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBolósGrego-Bessade_la_Pompa2007" class="citation journal cs1">Bolós V, Grego-Bessa J, de la Pompa JL (May 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fer.2006-0046">"Notch signaling in development and cancer"</a>. Endocrine Reviews. 28 (3): 339–363. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fer.2006-0046">10.1210/er.2006-0046</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17409286">17409286</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Endocrine+Reviews&rft.atitle=Notch+signaling+in+development+and+cancer&rft.volume=28&rft.issue=3&rft.pages=339-363&rft.date=2007-05&rft_id=info%3Adoi%2F10.1210%2Fer.2006-0046&rft_id=info%3Apmid%2F17409286&rft.aulast=Bol%C3%B3s&rft.aufirst=V&rft.au=Grego-Bessa%2C+J&rft.au=de+la+Pompa%2C+JL&rft_id=https%3A%2F%2Fdoi.org%2F10.1210%252Fer.2006-0046&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid20844536-46"><a href="#cite_ref-pmid20844536_46-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAguirreRubioGallo2010" class="citation journal cs1">Aguirre A, Rubio ME, Gallo V (September 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941915">"Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal"</a>. Nature. 467 (7313): 323–327. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2010Natur.467..323A">2010Natur.467..323A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature09347">10.1038/nature09347</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941915">2941915</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20844536">20844536</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Notch+and+EGFR+pathway+interaction+regulates+neural+stem+cell+number+and+self-renewal&rft.volume=467&rft.issue=7313&rft.pages=323-327&rft.date=2010-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2941915%23id-name%3DPMC&rft_id=info%3Apmid%2F20844536&rft_id=info%3Adoi%2F10.1038%2Fnature09347&rft_id=info%3Abibcode%2F2010Natur.467..323A&rft.aulast=Aguirre&rft.aufirst=A&rft.au=Rubio%2C+ME&rft.au=Gallo%2C+V&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2941915&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid11937492-47"><a href="#cite_ref-pmid11937492_47-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHitoshiAlexsonTropepeDonoviel2002" class="citation journal cs1">Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, et al. (April 2002). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186324">"Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells"</a>. Genes & Development. 16 (7): 846–858. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.975202">10.1101/gad.975202</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186324">186324</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11937492">11937492</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Notch+pathway+molecules+are+essential+for+the+maintenance%2C+but+not+the+generation%2C+of+mammalian+neural+stem+cells&rft.volume=16&rft.issue=7&rft.pages=846-858&rft.date=2002-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC186324%23id-name%3DPMC&rft_id=info%3Apmid%2F11937492&rft_id=info%3Adoi%2F10.1101%2Fgad.975202&rft.aulast=Hitoshi&rft.aufirst=S&rft.au=Alexson%2C+T&rft.au=Tropepe%2C+V&rft.au=Donoviel%2C+D&rft.au=Elia%2C+AJ&rft.au=Nye%2C+JS&rft.au=Conlon%2C+RA&rft.au=Mak%2C+TW&rft.au=Bernstein%2C+A&rft.au=van+der+Kooy%2C+D&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC186324&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid12482957-48"><a href="#cite_ref-pmid12482957_48-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLiuShirakawaLiSoma2003" class="citation journal cs1">Liu ZJ, Shirakawa T, Li Y, Soma A, Oka M, Dotto GP, et al. (January 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140667">"Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis"</a>. Molecular and Cellular Biology. 23 (1): 14–25. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.23.1.14-25.2003">10.1128/MCB.23.1.14-25.2003</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140667">140667</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12482957">12482957</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Regulation+of+Notch1+and+Dll4+by+vascular+endothelial+growth+factor+in+arterial+endothelial+cells%3A+implications+for+modulating+arteriogenesis+and+angiogenesis&rft.volume=23&rft.issue=1&rft.pages=14-25&rft.date=2003-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC140667%23id-name%3DPMC&rft_id=info%3Apmid%2F12482957&rft_id=info%3Adoi%2F10.1128%2FMCB.23.1.14-25.2003&rft.aulast=Liu&rft.aufirst=ZJ&rft.au=Shirakawa%2C+T&rft.au=Li%2C+Y&rft.au=Soma%2C+A&rft.au=Oka%2C+M&rft.au=Dotto%2C+GP&rft.au=Fairman%2C+RM&rft.au=Velazquez%2C+OC&rft.au=Herlyn%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC140667&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Grego-Bessa_2007-49">^ <a href="#cite_ref-Grego-Bessa_2007_49-0">a</a> <a href="#cite_ref-Grego-Bessa_2007_49-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGrego-BessaLuna-Zuritadel_MonteBolós2007" class="citation journal cs1">Grego-Bessa J, Luna-Zurita L, del Monte G, Bolós V, Melgar P, Arandilla A, et al. (March 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746361">"Notch signaling is essential for ventricular chamber development"</a>. Developmental Cell. 12 (3): 415–429. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.devcel.2006.12.011">10.1016/j.devcel.2006.12.011</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746361">2746361</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17336907">17336907</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Cell&rft.atitle=Notch+signaling+is+essential+for+ventricular+chamber+development&rft.volume=12&rft.issue=3&rft.pages=415-429&rft.date=2007-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2746361%23id-name%3DPMC&rft_id=info%3Apmid%2F17336907&rft_id=info%3Adoi%2F10.1016%2Fj.devcel.2006.12.011&rft.aulast=Grego-Bessa&rft.aufirst=J&rft.au=Luna-Zurita%2C+L&rft.au=del+Monte%2C+G&rft.au=Bol%C3%B3s%2C+V&rft.au=Melgar%2C+P&rft.au=Arandilla%2C+A&rft.au=Garratt%2C+AN&rft.au=Zang%2C+H&rft.au=Mukouyama%2C+YS&rft.au=Chen%2C+H&rft.au=Shou%2C+W&rft.au=Ballestar%2C+E&rft.au=Esteller%2C+M&rft.au=Rojas%2C+A&rft.au=P%C3%A9rez-Pomares%2C+JM&rft.au=de+la+Pompa%2C+JL&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2746361&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-50"><a href="#cite_ref-50">^</a> <a rel="nofollow" class="external text" href="http://www.cnb.csic.es/groups-en/DIO/lineas_dpto5/jose_luis_de_la_pompa/index_html?set_language=en">The notch signaling pathway in cardiac development and tissue homeostasis</a>[<a href="/wiki/Wikipedia:Link_rot" title="Wikipedia:Link rot">permanent dead link</a>‍] </li> <li id="cite_note-pmid14657333-51"><a href="#cite_ref-pmid14657333_51-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMurtaughStangerKwanMelton2003" class="citation journal cs1">Murtaugh LC, Stanger BZ, Kwan KM, Melton DA (December 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC299853">"Notch signaling controls multiple steps of pancreatic differentiation"</a>. Proceedings of the National Academy of Sciences of the United States of America. 100 (25): 14920–14925. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2003PNAS..10014920M">2003PNAS..10014920M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.2436557100">10.1073/pnas.2436557100</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC299853">299853</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14657333">14657333</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Notch+signaling+controls+multiple+steps+of+pancreatic+differentiation&rft.volume=100&rft.issue=25&rft.pages=14920-14925&rft.date=2003-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC299853%23id-name%3DPMC&rft_id=info%3Apmid%2F14657333&rft_id=info%3Adoi%2F10.1073%2Fpnas.2436557100&rft_id=info%3Abibcode%2F2003PNAS..10014920M&rft.aulast=Murtaugh&rft.aufirst=LC&rft.au=Stanger%2C+BZ&rft.au=Kwan%2C+KM&rft.au=Melton%2C+DA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC299853&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid15034002-52"><a href="#cite_ref-pmid15034002_52-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSanderPowell2004" class="citation journal cs1">Sander GR, Powell BC (April 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F002215540405200409">"Expression of notch receptors and ligands in the adult gut"</a>. The Journal of Histochemistry and Cytochemistry. 52 (4): 509–516. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F002215540405200409">10.1177/002215540405200409</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15034002">15034002</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Histochemistry+and+Cytochemistry&rft.atitle=Expression+of+notch+receptors+and+ligands+in+the+adult+gut&rft.volume=52&rft.issue=4&rft.pages=509-516&rft.date=2004-04&rft_id=info%3Adoi%2F10.1177%2F002215540405200409&rft_id=info%3Apmid%2F15034002&rft.aulast=Sander&rft.aufirst=GR&rft.au=Powell%2C+BC&rft_id=https%3A%2F%2Fdoi.org%2F10.1177%252F002215540405200409&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid15695512-53">^ <a href="#cite_ref-pmid15695512_53-0">a</a> <a href="#cite_ref-pmid15695512_53-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNobtaTsukazakiShibataXin2005" class="citation journal cs1">Nobta M, Tsukazaki T, Shibata Y, Xin C, Moriishi T, Sakano S, et al. (April 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M412891200">"Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling"</a>. The Journal of Biological Chemistry. 280 (16): 15842–15848. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M412891200">10.1074/jbc.M412891200</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15695512">15695512</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Critical+regulation+of+bone+morphogenetic+protein-induced+osteoblastic+differentiation+by+Delta1%2FJagged1-activated+Notch1+signaling&rft.volume=280&rft.issue=16&rft.pages=15842-15848&rft.date=2005-04&rft_id=info%3Adoi%2F10.1074%2Fjbc.M412891200&rft_id=info%3Apmid%2F15695512&rft.aulast=Nobta&rft.aufirst=M&rft.au=Tsukazaki%2C+T&rft.au=Shibata%2C+Y&rft.au=Xin%2C+C&rft.au=Moriishi%2C+T&rft.au=Sakano%2C+S&rft.au=Shindo%2C+H&rft.au=Yamaguchi%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M412891200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid23236128-54"><a href="#cite_ref-pmid23236128_54-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKimAlbackerLuJang2013" class="citation journal cs1">Kim PG, Albacker CE, Lu YF, Jang IH, Lim Y, Heffner GC, et al. (January 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545793">"Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition"</a>. Proceedings of the National Academy of Sciences of the United States of America. 110 (2): E141–E150. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2013PNAS..110E.141K">2013PNAS..110E.141K</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.1214361110">10.1073/pnas.1214361110</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545793">3545793</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23236128">23236128</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Signaling+axis+involving+Hedgehog%2C+Notch%2C+and+Scl+promotes+the+embryonic+endothelial-to-hematopoietic+transition&rft.volume=110&rft.issue=2&rft.pages=E141-E150&rft.date=2013-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3545793%23id-name%3DPMC&rft_id=info%3Apmid%2F23236128&rft_id=info%3Adoi%2F10.1073%2Fpnas.1214361110&rft_id=info%3Abibcode%2F2013PNAS..110E.141K&rft.aulast=Kim&rft.aufirst=PG&rft.au=Albacker%2C+CE&rft.au=Lu%2C+YF&rft.au=Jang%2C+IH&rft.au=Lim%2C+Y&rft.au=Heffner%2C+GC&rft.au=Arora%2C+N&rft.au=Bowman%2C+TV&rft.au=Lin%2C+MI&rft.au=Lensch%2C+MW&rft.au=De+Los+Angeles%2C+A&rft.au=Zon%2C+LI&rft.au=Loewer%2C+S&rft.au=Daley%2C+GQ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3545793&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-55"><a href="#cite_ref-55">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLakyFowlkes2008" class="citation journal cs1">Laky K, Fowlkes BJ (April 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475578">"Notch signaling in CD4 and CD8 T cell development"</a>. Current Opinion in Immunology. 20 (2): 197–202. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.coi.2008.03.004">10.1016/j.coi.2008.03.004</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475578">2475578</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18434124">18434124</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Opinion+in+Immunology&rft.atitle=Notch+signaling+in+CD4+and+CD8+T+cell+development&rft.volume=20&rft.issue=2&rft.pages=197-202&rft.date=2008-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2475578%23id-name%3DPMC&rft_id=info%3Apmid%2F18434124&rft_id=info%3Adoi%2F10.1016%2Fj.coi.2008.03.004&rft.aulast=Laky&rft.aufirst=K&rft.au=Fowlkes%2C+BJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2475578&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid15535842-56"><a href="#cite_ref-pmid15535842_56-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDontuJacksonMcNicholasKawamura2004" class="citation journal cs1">Dontu G, Jackson KW, McNicholas E, Kawamura MJ, Abdallah WM, Wicha MS (2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064073">"Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells"</a>. Breast Cancer Research. 6 (6): R605–R615. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Fbcr920">10.1186/bcr920</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064073">1064073</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15535842">15535842</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Breast+Cancer+Research&rft.atitle=Role+of+Notch+signaling+in+cell-fate+determination+of+human+mammary+stem%2Fprogenitor+cells&rft.volume=6&rft.issue=6&rft.pages=R605-R615&rft.date=2004&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1064073%23id-name%3DPMC&rft_id=info%3Apmid%2F15535842&rft_id=info%3Adoi%2F10.1186%2Fbcr920&rft.aulast=Dontu&rft.aufirst=G&rft.au=Jackson%2C+KW&rft.au=McNicholas%2C+E&rft.au=Kawamura%2C+MJ&rft.au=Abdallah%2C+WM&rft.au=Wicha%2C+MS&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1064073&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-57"><a href="#cite_ref-57">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGusehBoresStangerZhou2009" class="citation journal cs1">Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J (May 2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673763">"Notch signaling promotes airway mucous metaplasia and inhibits alveolar development"</a>. Development. 136 (10): 1751–1759. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.029249">10.1242/dev.029249</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673763">2673763</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19369400">19369400</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Notch+signaling+promotes+airway+mucous+metaplasia+and+inhibits+alveolar+development&rft.volume=136&rft.issue=10&rft.pages=1751-1759&rft.date=2009-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2673763%23id-name%3DPMC&rft_id=info%3Apmid%2F19369400&rft_id=info%3Adoi%2F10.1242%2Fdev.029249&rft.aulast=Guseh&rft.aufirst=JS&rft.au=Bores%2C+SA&rft.au=Stanger%2C+BZ&rft.au=Zhou%2C+Q&rft.au=Anderson%2C+WJ&rft.au=Melton%2C+DA&rft.au=Rajagopal%2C+J&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2673763&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-58"><a href="#cite_ref-58">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBhandariSeoRohJung2010" class="citation journal cs1">Bhandari DR, Seo KW, Roh KH, Jung JW, Kang SK, Kang KS (May 2010). Pera M (ed.). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864743">"REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells"</a>. PLOS ONE. 5 (5): e10493. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2010PLoSO...510493B">2010PLoSO...510493B</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pone.0010493">10.1371/journal.pone.0010493</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864743">2864743</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20463961">20463961</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+ONE&rft.atitle=REX-1+expression+and+p38+MAPK+activation+status+can+determine+proliferation%2Fdifferentiation+fates+in+human+mesenchymal+stem+cells&rft.volume=5&rft.issue=5&rft.pages=e10493&rft.date=2010-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2864743%23id-name%3DPMC&rft_id=info%3Apmid%2F20463961&rft_id=info%3Adoi%2F10.1371%2Fjournal.pone.0010493&rft_id=info%3Abibcode%2F2010PLoSO...510493B&rft.aulast=Bhandari&rft.aufirst=DR&rft.au=Seo%2C+KW&rft.au=Roh%2C+KH&rft.au=Jung%2C+JW&rft.au=Kang%2C+SK&rft.au=Kang%2C+KS&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2864743&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-59"><a href="#cite_ref-59">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFellerSchneiderSchuster-GosslerGossler2008" class="citation journal cs1">Feller J, Schneider A, Schuster-Gossler K, Gossler A (August 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518812">"Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation"</a>. Genes & Development. 22 (16): 2166–2171. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.480408">10.1101/gad.480408</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518812">2518812</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18708576">18708576</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Noncyclic+Notch+activity+in+the+presomitic+mesoderm+demonstrates+uncoupling+of+somite+compartmentalization+and+boundary+formation&rft.volume=22&rft.issue=16&rft.pages=2166-2171&rft.date=2008-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2518812%23id-name%3DPMC&rft_id=info%3Apmid%2F18708576&rft_id=info%3Adoi%2F10.1101%2Fgad.480408&rft.aulast=Feller&rft.aufirst=J&rft.au=Schneider%2C+A&rft.au=Schuster-Gossler%2C+K&rft.au=Gossler%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2518812&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-60"><a href="#cite_ref-60">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLevin2005" class="citation journal cs1">Levin M (January 2005). "Left-right asymmetry in embryonic development: a comprehensive review". Mechanisms of Development. 122 (1): 3–25. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.mod.2004.08.006">10.1016/j.mod.2004.08.006</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15582774">15582774</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:15211728">15211728</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mechanisms+of+Development&rft.atitle=Left-right+asymmetry+in+embryonic+development%3A+a+comprehensive+review&rft.volume=122&rft.issue=1&rft.pages=3-25&rft.date=2005-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A15211728%23id-name%3DS2CID&rft_id=info%3Apmid%2F15582774&rft_id=info%3Adoi%2F10.1016%2Fj.mod.2004.08.006&rft.aulast=Levin&rft.aufirst=M&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-61"><a href="#cite_ref-61">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLambieKimble1991" class="citation journal cs1">Lambie EJ, Kimble J (May 1991). "Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions". Development. 112 (1): 231–240. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.112.1.231">10.1242/dev.112.1.231</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1769331">1769331</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Two+homologous+regulatory+genes%2C+lin-12+and+glp-1%2C+have+overlapping+functions&rft.volume=112&rft.issue=1&rft.pages=231-240&rft.date=1991-05&rft_id=info%3Adoi%2F10.1242%2Fdev.112.1.231&rft_id=info%3Apmid%2F1769331&rft.aulast=Lambie&rft.aufirst=EJ&rft.au=Kimble%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-62"><a href="#cite_ref-62">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGilbert_SF2016" class="citation book cs1">Gilbert SF (2016). Developmental biology (11th ed.). Sinauer. p. 272. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-60535-470-5" title="Special:BookSources/978-1-60535-470-5"><bdi>978-1-60535-470-5</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Developmental+biology&rft.pages=272&rft.edition=11th&rft.pub=Sinauer&rft.date=2016&rft.isbn=978-1-60535-470-5&rft.au=Gilbert+SF&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988">[<a href="/wiki/Wikipedia:Citing_sources" title="Wikipedia:Citing sources">page needed</a>] </li> <li id="cite_note-Conlon_RA,_Reaume_AG,_Rossant_J_1995_1533–45-63">^ <a href="#cite_ref-Conlon_RA,_Reaume_AG,_Rossant_J_1995_1533–45_63-0">a</a> <a href="#cite_ref-Conlon_RA,_Reaume_AG,_Rossant_J_1995_1533–45_63-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFConlonReaumeRossant1995" class="citation journal cs1">Conlon RA, Reaume AG, Rossant J (May 1995). "Notch1 is required for the coordinate segmentation of somites". Development. 121 (5): 1533–1545. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.121.5.1533">10.1242/dev.121.5.1533</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7789282">7789282</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Notch1+is+required+for+the+coordinate+segmentation+of+somites&rft.volume=121&rft.issue=5&rft.pages=1533-1545&rft.date=1995-05&rft_id=info%3Adoi%2F10.1242%2Fdev.121.5.1533&rft_id=info%3Apmid%2F7789282&rft.aulast=Conlon&rft.aufirst=RA&rft.au=Reaume%2C+AG&rft.au=Rossant%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-64"><a href="#cite_ref-64">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHrabĕ_de_AngelisMcIntyreGossler1997" class="citation journal cs1">Hrabĕ de Angelis M, McIntyre J, Gossler A (April 1997). "Maintenance of somite borders in mice requires the Delta homologue DII1". Nature. 386 (6626): 717–721. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1997Natur.386..717D">1997Natur.386..717D</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F386717a0">10.1038/386717a0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9109488">9109488</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4331445">4331445</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Maintenance+of+somite+borders+in+mice+requires+the+Delta+homologue+DII1&rft.volume=386&rft.issue=6626&rft.pages=717-721&rft.date=1997-04&rft_id=info%3Adoi%2F10.1038%2F386717a0&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4331445%23id-name%3DS2CID&rft_id=info%3Apmid%2F9109488&rft_id=info%3Abibcode%2F1997Natur.386..717D&rft.aulast=Hrab%C4%95+de+Angelis&rft.aufirst=M&rft.au=McIntyre%2C+J&rft.au=Gossler%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-65"><a href="#cite_ref-65">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFvan_EedenGranatoSchachBrand1996" class="citation journal cs1">van Eeden FJ, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, et al. (December 1996). "Mutations affecting somite formation and patterning in the zebrafish, Danio rerio". Development. 123: 153–164. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.123.1.153">10.1242/dev.123.1.153</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9007237">9007237</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Mutations+affecting+somite+formation+and+patterning+in+the+zebrafish%2C+Danio+rerio&rft.volume=123&rft.pages=153-164&rft.date=1996-12&rft_id=info%3Adoi%2F10.1242%2Fdev.123.1.153&rft_id=info%3Apmid%2F9007237&rft.aulast=van+Eeden&rft.aufirst=FJ&rft.au=Granato%2C+M&rft.au=Schach%2C+U&rft.au=Brand%2C+M&rft.au=Furutani-Seiki%2C+M&rft.au=Haffter%2C+P&rft.au=Hammerschmidt%2C+M&rft.au=Heisenberg%2C+CP&rft.au=Jiang%2C+YJ&rft.au=Kane%2C+DA&rft.au=Kelsh%2C+RN&rft.au=Mullins%2C+MC&rft.au=Odenthal%2C+J&rft.au=Warga%2C+RM&rft.au=Allende%2C+ML&rft.au=Weinberg%2C+ES&rft.au=N%C3%BCsslein-Volhard%2C+C&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-66"><a href="#cite_ref-66">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHuppertIlaganDe_StrooperKopan2005" class="citation journal cs1">Huppert SS, Ilagan MX, De Strooper B, Kopan R (May 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.devcel.2005.02.019">"Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation"</a>. Developmental Cell. 8 (5): 677–688. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.devcel.2005.02.019">10.1016/j.devcel.2005.02.019</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15866159">15866159</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Cell&rft.atitle=Analysis+of+Notch+function+in+presomitic+mesoderm+suggests+a+gamma-secretase-independent+role+for+presenilins+in+somite+differentiation&rft.volume=8&rft.issue=5&rft.pages=677-688&rft.date=2005-05&rft_id=info%3Adoi%2F10.1016%2Fj.devcel.2005.02.019&rft_id=info%3Apmid%2F15866159&rft.aulast=Huppert&rft.aufirst=SS&rft.au=Ilagan%2C+MX&rft.au=De+Strooper%2C+B&rft.au=Kopan%2C+R&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.devcel.2005.02.019&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-67"><a href="#cite_ref-67">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWahiBochterCole2016" class="citation journal cs1">Wahi K, Bochter MS, Cole SE (January 2016). "The many roles of Notch signaling during vertebrate somitogenesis". Seminars in Cell & Developmental Biology. 49: 68–75. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.semcdb.2014.11.010">10.1016/j.semcdb.2014.11.010</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25483003">25483003</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:10822545">10822545</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Seminars+in+Cell+%26+Developmental+Biology&rft.atitle=The+many+roles+of+Notch+signaling+during+vertebrate+somitogenesis&rft.volume=49&rft.pages=68-75&rft.date=2016-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A10822545%23id-name%3DS2CID&rft_id=info%3Apmid%2F25483003&rft_id=info%3Adoi%2F10.1016%2Fj.semcdb.2014.11.010&rft.aulast=Wahi&rft.aufirst=K&rft.au=Bochter%2C+MS&rft.au=Cole%2C+SE&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-68"><a href="#cite_ref-68">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLowellJonesLe_RouxDunne2000" class="citation journal cs1">Lowell S, Jones P, Le Roux I, Dunne J, Watt FM (May 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0960-9822%2800%2900451-6">"Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters"</a>. Current Biology. 10 (9): 491–500. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2000CBio...10..491L">2000CBio...10..491L</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0960-9822%2800%2900451-6">10.1016/s0960-9822(00)00451-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10801437">10801437</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:8927528">8927528</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Stimulation+of+human+epidermal+differentiation+by+delta-notch+signalling+at+the+boundaries+of+stem-cell+clusters&rft.volume=10&rft.issue=9&rft.pages=491-500&rft.date=2000-05&rft_id=info%3Adoi%2F10.1016%2Fs0960-9822%2800%2900451-6&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A8927528%23id-name%3DS2CID&rft_id=info%3Apmid%2F10801437&rft_id=info%3Abibcode%2F2000CBio...10..491L&rft.aulast=Lowell&rft.aufirst=S&rft.au=Jones%2C+P&rft.au=Le+Roux%2C+I&rft.au=Dunne%2C+J&rft.au=Watt%2C+FM&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fs0960-9822%252800%252900451-6&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-69"><a href="#cite_ref-69">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEzrattyPasolliFuchs2016" class="citation journal cs1">Ezratty EJ, Pasolli HA, Fuchs E (July 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932368">"A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation"</a>. The Journal of Cell Biology. 214 (1): 89–101. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.201508082">10.1083/jcb.201508082</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932368">4932368</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27354375">27354375</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Cell+Biology&rft.atitle=A+Presenilin-2-ARF4+trafficking+axis+modulates+Notch+signaling+during+epidermal+differentiation&rft.volume=214&rft.issue=1&rft.pages=89-101&rft.date=2016-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4932368%23id-name%3DPMC&rft_id=info%3Apmid%2F27354375&rft_id=info%3Adoi%2F10.1083%2Fjcb.201508082&rft.aulast=Ezratty&rft.aufirst=EJ&rft.au=Pasolli%2C+HA&rft.au=Fuchs%2C+E&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4932368&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-70"><a href="#cite_ref-70">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPoulson1937" class="citation journal cs1">Poulson DF (March 1937). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1076884">"Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster"</a>. Proceedings of the National Academy of Sciences of the United States of America. 23 (3): 133–137. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1937PNAS...23..133P">1937PNAS...23..133P</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.23.3.133">10.1073/pnas.23.3.133</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1076884">1076884</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16588136">16588136</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Chromosomal+Deficiencies+and+the+Embryonic+Development+of+Drosophila+Melanogaster&rft.volume=23&rft.issue=3&rft.pages=133-137&rft.date=1937-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1076884%23id-name%3DPMC&rft_id=info%3Apmid%2F16588136&rft_id=info%3Adoi%2F10.1073%2Fpnas.23.3.133&rft_id=info%3Abibcode%2F1937PNAS...23..133P&rft.aulast=Poulson&rft.aufirst=DF&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1076884&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-dada-71">^ <a href="#cite_ref-dada_71-0">a</a> <a href="#cite_ref-dada_71-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFurukawaMukherjeeBaoMorrow2000" class="citation journal cs1">Furukawa T, Mukherjee S, Bao ZZ, Morrow EM, Cepko CL (May 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2800%2981171-X">"rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells"</a>. Neuron. 26 (2): 383–394. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2800%2981171-X">10.1016/S0896-6273(00)81171-X</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10839357">10839357</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:16444353">16444353</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=rax%2C+Hes1%2C+and+notch1+promote+the+formation+of+M%C3%BCller+glia+by+postnatal+retinal+progenitor+cells&rft.volume=26&rft.issue=2&rft.pages=383-394&rft.date=2000-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A16444353%23id-name%3DS2CID&rft_id=info%3Apmid%2F10839357&rft_id=info%3Adoi%2F10.1016%2FS0896-6273%2800%2981171-X&rft.aulast=Furukawa&rft.aufirst=T&rft.au=Mukherjee%2C+S&rft.au=Bao%2C+ZZ&rft.au=Morrow%2C+EM&rft.au=Cepko%2C+CL&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0896-6273%252800%252981171-X&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-baba-72">^ <a href="#cite_ref-baba_72-0">a</a> <a href="#cite_ref-baba_72-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFScheerGrothHansCampos-Ortega2001" class="citation journal cs1">Scheer N, Groth A, Hans S, Campos-Ortega JA (April 2001). "An instructive function for Notch in promoting gliogenesis in the zebrafish retina". Development. 128 (7): 1099–1107. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.128.7.1099">10.1242/dev.128.7.1099</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11245575">11245575</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=An+instructive+function+for+Notch+in+promoting+gliogenesis+in+the+zebrafish+retina&rft.volume=128&rft.issue=7&rft.pages=1099-1107&rft.date=2001-04&rft_id=info%3Adoi%2F10.1242%2Fdev.128.7.1099&rft_id=info%3Apmid%2F11245575&rft.aulast=Scheer&rft.aufirst=N&rft.au=Groth%2C+A&rft.au=Hans%2C+S&rft.au=Campos-Ortega%2C+JA&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-neurite-73">^ <a href="#cite_ref-neurite_73-0">a</a> <a href="#cite_ref-neurite_73-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRedmondOhHicksWeinmaster2000" class="citation journal cs1">Redmond L, Oh SR, Hicks C, Weinmaster G, Ghosh A (January 2000). "Nuclear Notch1 signaling and the regulation of dendritic development". Nature Neuroscience. 3 (1): 30–40. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F71104">10.1038/71104</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10607392">10607392</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:14774606">14774606</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Neuroscience&rft.atitle=Nuclear+Notch1+signaling+and+the+regulation+of+dendritic+development&rft.volume=3&rft.issue=1&rft.pages=30-40&rft.date=2000-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A14774606%23id-name%3DS2CID&rft_id=info%3Apmid%2F10607392&rft_id=info%3Adoi%2F10.1038%2F71104&rft.aulast=Redmond&rft.aufirst=L&rft.au=Oh%2C+SR&rft.au=Hicks%2C+C&rft.au=Weinmaster%2C+G&rft.au=Ghosh%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-learning-74">^ <a href="#cite_ref-learning_74-0">a</a> <a href="#cite_ref-learning_74-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCostaHonjoSilva2003" class="citation journal cs1">Costa RM, Honjo T, Silva AJ (August 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0960-9822%2803%2900492-5">"Learning and memory deficits in Notch mutant mice"</a>. Current Biology. 13 (15): 1348–1354. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2003CBio...13.1348C">2003CBio...13.1348C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0960-9822%2803%2900492-5">10.1016/S0960-9822(03)00492-5</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12906797">12906797</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:15150614">15150614</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Learning+and+memory+deficits+in+Notch+mutant+mice&rft.volume=13&rft.issue=15&rft.pages=1348-1354&rft.date=2003-08&rft_id=info%3Adoi%2F10.1016%2FS0960-9822%2803%2900492-5&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A15150614%23id-name%3DS2CID&rft_id=info%3Apmid%2F12906797&rft_id=info%3Abibcode%2F2003CBio...13.1348C&rft.aulast=Costa&rft.aufirst=RM&rft.au=Honjo%2C+T&rft.au=Silva%2C+AJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0960-9822%252803%252900492-5&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-75"><a href="#cite_ref-75">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhongJiangWeinmasterJan1997" class="citation journal cs1">Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN (May 1997). "Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis". Development. 124 (10): 1887–1897. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.124.10.1887">10.1242/dev.124.10.1887</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9169836">9169836</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Differential+expression+of+mammalian+Numb%2C+Numblike+and+Notch1+suggests+distinct+roles+during+mouse+cortical+neurogenesis&rft.volume=124&rft.issue=10&rft.pages=1887-1897&rft.date=1997-05&rft_id=info%3Adoi%2F10.1242%2Fdev.124.10.1887&rft_id=info%3Apmid%2F9169836&rft.aulast=Zhong&rft.aufirst=W&rft.au=Jiang%2C+MM&rft.au=Weinmaster%2C+G&rft.au=Jan%2C+LY&rft.au=Jan%2C+YN&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-76"><a href="#cite_ref-76">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLiWangShenSchonemann2003" class="citation journal cs1">Li HS, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, et al. (December 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2803%2900755-4">"Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis"</a>. Neuron. 40 (6): 1105–1118. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2803%2900755-4">10.1016/S0896-6273(03)00755-4</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14687546">14687546</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:6525042">6525042</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Inactivation+of+Numb+and+Numblike+in+embryonic+dorsal+forebrain+impairs+neurogenesis+and+disrupts+cortical+morphogenesis&rft.volume=40&rft.issue=6&rft.pages=1105-1118&rft.date=2003-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A6525042%23id-name%3DS2CID&rft_id=info%3Apmid%2F14687546&rft_id=info%3Adoi%2F10.1016%2FS0896-6273%2803%2900755-4&rft.aulast=Li&rft.aufirst=HS&rft.au=Wang%2C+D&rft.au=Shen%2C+Q&rft.au=Schonemann%2C+MD&rft.au=Gorski%2C+JA&rft.au=Jones%2C+KR&rft.au=Temple%2C+S&rft.au=Jan%2C+LY&rft.au=Jan%2C+YN&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0896-6273%252803%252900755-4&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-77"><a href="#cite_ref-77">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRashLimBreunigVaccarino2011" class="citation journal cs1">Rash BG, Lim HD, Breunig JJ, Vaccarino FM (October 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235689">"FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis"</a>. The Journal of Neuroscience. 31 (43): 15604–15617. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.4439-11.2011">10.1523/JNEUROSCI.4439-11.2011</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235689">3235689</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22031906">22031906</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=FGF+signaling+expands+embryonic+cortical+surface+area+by+regulating+Notch-dependent+neurogenesis&rft.volume=31&rft.issue=43&rft.pages=15604-15617&rft.date=2011-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3235689%23id-name%3DPMC&rft_id=info%3Apmid%2F22031906&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.4439-11.2011&rft.aulast=Rash&rft.aufirst=BG&rft.au=Lim%2C+HD&rft.au=Breunig%2C+JJ&rft.au=Vaccarino%2C+FM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3235689&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-78"><a href="#cite_ref-78">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRashTomasiLimSuh2013" class="citation journal cs1">Rash BG, Tomasi S, Lim HD, Suh CY, Vaccarino FM (June 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693057">"Cortical gyrification induced by fibroblast growth factor 2 in the mouse brain"</a>. The Journal of Neuroscience. 33 (26): 10802–10814. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.3621-12.2013">10.1523/JNEUROSCI.3621-12.2013</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693057">3693057</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23804101">23804101</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Cortical+gyrification+induced+by+fibroblast+growth+factor+2+in+the+mouse+brain&rft.volume=33&rft.issue=26&rft.pages=10802-10814&rft.date=2013-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3693057%23id-name%3DPMC&rft_id=info%3Apmid%2F23804101&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.3621-12.2013&rft.aulast=Rash&rft.aufirst=BG&rft.au=Tomasi%2C+S&rft.au=Lim%2C+HD&rft.au=Suh%2C+CY&rft.au=Vaccarino%2C+FM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3693057&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-79"><a href="#cite_ref-79">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAndroutsellis-TheotokisLekerSoldnerHoeppner2006" class="citation journal cs1">Androutsellis-Theotokis A, Leker RR, Soldner F, Hoeppner DJ, Ravin R, Poser SW, et al. (August 2006). <a rel="nofollow" class="external text" href="https://zenodo.org/record/1233295">"Notch signalling regulates stem cell numbers in vitro and in vivo"</a>. Nature. 442 (7104): 823–826. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2006Natur.442..823A">2006Natur.442..823A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature04940">10.1038/nature04940</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16799564">16799564</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4372065">4372065</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Notch+signalling+regulates+stem+cell+numbers+in+vitro+and+in+vivo&rft.volume=442&rft.issue=7104&rft.pages=823-826&rft.date=2006-08&rft_id=info%3Adoi%2F10.1038%2Fnature04940&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4372065%23id-name%3DS2CID&rft_id=info%3Apmid%2F16799564&rft_id=info%3Abibcode%2F2006Natur.442..823A&rft.aulast=Androutsellis-Theotokis&rft.aufirst=A&rft.au=Leker%2C+RR&rft.au=Soldner%2C+F&rft.au=Hoeppner%2C+DJ&rft.au=Ravin%2C+R&rft.au=Poser%2C+SW&rft.au=Rueger%2C+MA&rft.au=Bae%2C+SK&rft.au=Kittappa%2C+R&rft.au=McKay%2C+RD&rft_id=https%3A%2F%2Fzenodo.org%2Frecord%2F1233295&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-80"><a href="#cite_ref-80">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRusanescuMao2014" class="citation journal cs1">Rusanescu G, Mao J (October 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244024">"Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord"</a>. Journal of Cellular and Molecular Medicine. 18 (10): 2103–2116. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fjcmm.12362">10.1111/jcmm.12362</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244024">4244024</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25164209">25164209</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Cellular+and+Molecular+Medicine&rft.atitle=Notch3+is+necessary+for+neuronal+differentiation+and+maturation+in+the+adult+spinal+cord&rft.volume=18&rft.issue=10&rft.pages=2103-2116&rft.date=2014-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4244024%23id-name%3DPMC&rft_id=info%3Apmid%2F25164209&rft_id=info%3Adoi%2F10.1111%2Fjcmm.12362&rft.aulast=Rusanescu&rft.aufirst=G&rft.au=Mao%2C+J&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4244024&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid14729486-81"><a href="#cite_ref-pmid14729486_81-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKleinZilianSuterTaylor2004" class="citation journal cs1">Klein AL, Zilian O, Suter U, Taylor V (February 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ydbio.2003.10.017">"Murine numb regulates granule cell maturation in the cerebellum"</a>. Developmental Biology. 266 (1): 161–177. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ydbio.2003.10.017">10.1016/j.ydbio.2003.10.017</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14729486">14729486</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Biology&rft.atitle=Murine+numb+regulates+granule+cell+maturation+in+the+cerebellum&rft.volume=266&rft.issue=1&rft.pages=161-177&rft.date=2004-02&rft_id=info%3Adoi%2F10.1016%2Fj.ydbio.2003.10.017&rft_id=info%3Apmid%2F14729486&rft.aulast=Klein&rft.aufirst=AL&rft.au=Zilian%2C+O&rft.au=Suter%2C+U&rft.au=Taylor%2C+V&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.ydbio.2003.10.017&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-82"><a href="#cite_ref-82">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHuangLiTangWiggins2005" class="citation journal cs1">Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, et al. (January 2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540232">"Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization"</a>. Genes & Development. 19 (1): 138–151. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.1246005">10.1101/gad.1246005</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540232">540232</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15598981">15598981</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Targeted+deletion+of+numb+and+numblike+in+sensory+neurons+reveals+their+essential+functions+in+axon+arborization&rft.volume=19&rft.issue=1&rft.pages=138-151&rft.date=2005-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC540232%23id-name%3DPMC&rft_id=info%3Apmid%2F15598981&rft_id=info%3Adoi%2F10.1101%2Fgad.1246005&rft.aulast=Huang&rft.aufirst=EJ&rft.au=Li%2C+H&rft.au=Tang%2C+AA&rft.au=Wiggins%2C+AK&rft.au=Neve%2C+RL&rft.au=Zhong%2C+W&rft.au=Jan%2C+LY&rft.au=Jan%2C+YN&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC540232&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-83"><a href="#cite_ref-83">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWooParkGwonArumugam2009" class="citation journal cs1">Woo HN, Park JS, Gwon AR, Arumugam TV, Jo DG (December 2009). "Alzheimer's disease and Notch signaling". Biochemical and Biophysical Research Communications. 390 (4): 1093–1097. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bbrc.2009.10.093">10.1016/j.bbrc.2009.10.093</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19853579">19853579</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Alzheimer%27s+disease+and+Notch+signaling&rft.volume=390&rft.issue=4&rft.pages=1093-1097&rft.date=2009-12&rft_id=info%3Adoi%2F10.1016%2Fj.bbrc.2009.10.093&rft_id=info%3Apmid%2F19853579&rft.aulast=Woo&rft.aufirst=HN&rft.au=Park%2C+JS&rft.au=Gwon%2C+AR&rft.au=Arumugam%2C+TV&rft.au=Jo%2C+DG&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-84"><a href="#cite_ref-84">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPresenteAndresNye2001" class="citation journal cs1">Presente A, Andres A, Nye JS (October 2001). "Requirement of Notch in adulthood for neurological function and longevity". NeuroReport. 12 (15): 3321–3325. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F00001756-200110290-00035">10.1097/00001756-200110290-00035</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11711879">11711879</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:8329715">8329715</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=NeuroReport&rft.atitle=Requirement+of+Notch+in+adulthood+for+neurological+function+and+longevity&rft.volume=12&rft.issue=15&rft.pages=3321-3325&rft.date=2001-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A8329715%23id-name%3DS2CID&rft_id=info%3Apmid%2F11711879&rft_id=info%3Adoi%2F10.1097%2F00001756-200110290-00035&rft.aulast=Presente&rft.aufirst=A&rft.au=Andres%2C+A&rft.au=Nye%2C+JS&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid15066262-85"><a href="#cite_ref-pmid15066262_85-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSauraChoiBeglopoulosMalkani2004" class="citation journal cs1">Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, et al. (April 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2804%2900182-5">"Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration"</a>. Neuron. 42 (1): 23–36. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2804%2900182-5">10.1016/S0896-6273(04)00182-5</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15066262">15066262</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:17550860">17550860</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Loss+of+presenilin+function+causes+impairments+of+memory+and+synaptic+plasticity+followed+by+age-dependent+neurodegeneration&rft.volume=42&rft.issue=1&rft.pages=23-36&rft.date=2004-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A17550860%23id-name%3DS2CID&rft_id=info%3Apmid%2F15066262&rft_id=info%3Adoi%2F10.1016%2FS0896-6273%2804%2900182-5&rft.aulast=Saura&rft.aufirst=CA&rft.au=Choi%2C+SY&rft.au=Beglopoulos%2C+V&rft.au=Malkani%2C+S&rft.au=Zhang%2C+D&rft.au=Shankaranarayana+Rao%2C+BS&rft.au=Chattarji%2C+S&rft.au=Kelleher%2C+RJ&rft.au=Kandel%2C+ER&rft.au=Duff%2C+K&rft.au=Kirkwood%2C+A&rft.au=Shen%2C+J&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0896-6273%252804%252900182-5&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-86"><a href="#cite_ref-86">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDe_Strooper2014" class="citation journal cs1">De Strooper B (November 2014). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2014.10.016">"Lessons from a failed γ-secretase Alzheimer trial"</a>. Cell. 159 (4): 721–726. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2014.10.016">10.1016/j.cell.2014.10.016</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25417150">25417150</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Lessons+from+a+failed+%CE%B3-secretase+Alzheimer+trial&rft.volume=159&rft.issue=4&rft.pages=721-726&rft.date=2014-11&rft_id=info%3Adoi%2F10.1016%2Fj.cell.2014.10.016&rft_id=info%3Apmid%2F25417150&rft.aulast=De+Strooper&rft.aufirst=B&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.cell.2014.10.016&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-87"><a href="#cite_ref-87">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKume2012" class="citation book cs1">Kume T (2012). "Ligand-Dependent Notch Signaling in Vascular Formation". Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology. Vol. 727. pp. 210–222. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2F978-1-4614-0899-4_16">10.1007/978-1-4614-0899-4_16</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4614-0898-7" title="Special:BookSources/978-1-4614-0898-7"><bdi>978-1-4614-0898-7</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22399350">22399350</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Ligand-Dependent+Notch+Signaling+in+Vascular+Formation&rft.btitle=Notch+Signaling+in+Embryology+and+Cancer&rft.series=Advances+in+Experimental+Medicine+and+Biology&rft.pages=210-222&rft.date=2012&rft_id=info%3Apmid%2F22399350&rft_id=info%3Adoi%2F10.1007%2F978-1-4614-0899-4_16&rft.isbn=978-1-4614-0898-7&rft.aulast=Kume&rft.aufirst=T&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-haha-88">^ <a href="#cite_ref-haha_88-0">a</a> <a href="#cite_ref-haha_88-1">b</a> <a href="#cite_ref-haha_88-2">c</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNiessenKarsan2008" class="citation journal cs1">Niessen K, Karsan A (May 2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1161%2FCIRCRESAHA.108.174318">"Notch signaling in cardiac development"</a>. Circulation Research. 102 (10): 1169–1181. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1161%2FCIRCRESAHA.108.174318">10.1161/CIRCRESAHA.108.174318</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18497317">18497317</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Circulation+Research&rft.atitle=Notch+signaling+in+cardiac+development&rft.volume=102&rft.issue=10&rft.pages=1169-1181&rft.date=2008-05&rft_id=info%3Adoi%2F10.1161%2FCIRCRESAHA.108.174318&rft_id=info%3Apmid%2F18497317&rft.aulast=Niessen&rft.aufirst=K&rft.au=Karsan%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1161%252FCIRCRESAHA.108.174318&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-89"><a href="#cite_ref-89">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRutenbergFischerJiaGessler2006" class="citation journal cs1">Rutenberg JB, Fischer A, Jia H, Gessler M, Zhong TP, Mercola M (November 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619037">"Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors"</a>. Development. 133 (21): 4381–4390. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.02607">10.1242/dev.02607</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619037">3619037</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17021042">17021042</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Developmental+patterning+of+the+cardiac+atrioventricular+canal+by+Notch+and+Hairy-related+transcription+factors&rft.volume=133&rft.issue=21&rft.pages=4381-4390&rft.date=2006-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3619037%23id-name%3DPMC&rft_id=info%3Apmid%2F17021042&rft_id=info%3Adoi%2F10.1242%2Fdev.02607&rft.aulast=Rutenberg&rft.aufirst=JB&rft.au=Fischer%2C+A&rft.au=Jia%2C+H&rft.au=Gessler%2C+M&rft.au=Zhong%2C+TP&rft.au=Mercola%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3619037&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-90"><a href="#cite_ref-90">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKokuboTomita-MiyagawaHamadaSaga2007" class="citation journal cs1">Kokubo H, Tomita-Miyagawa S, Hamada Y, Saga Y (February 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.02777">"Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2"</a>. Development. 134 (4): 747–755. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.02777">10.1242/dev.02777</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17259303">17259303</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Hesr1+and+Hesr2+regulate+atrioventricular+boundary+formation+in+the+developing+heart+through+the+repression+of+Tbx2&rft.volume=134&rft.issue=4&rft.pages=747-755&rft.date=2007-02&rft_id=info%3Adoi%2F10.1242%2Fdev.02777&rft_id=info%3Apmid%2F17259303&rft.aulast=Kokubo&rft.aufirst=H&rft.au=Tomita-Miyagawa%2C+S&rft.au=Hamada%2C+Y&rft.au=Saga%2C+Y&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fdev.02777&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-ReferenceA-91">^ <a href="#cite_ref-ReferenceA_91-0">a</a> <a href="#cite_ref-ReferenceA_91-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTimmermanGrego-BessaRayaBertrán2004" class="citation journal cs1">Timmerman LA, Grego-Bessa J, Raya A, Bertrán E, Pérez-Pomares JM, Díez J, et al. (January 2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314285">"Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation"</a>. Genes & Development. 18 (1): 99–115. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.276304">10.1101/gad.276304</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314285">314285</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14701881">14701881</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Notch+promotes+epithelial-mesenchymal+transition+during+cardiac+development+and+oncogenic+transformation&rft.volume=18&rft.issue=1&rft.pages=99-115&rft.date=2004-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC314285%23id-name%3DPMC&rft_id=info%3Apmid%2F14701881&rft_id=info%3Adoi%2F10.1101%2Fgad.276304&rft.aulast=Timmerman&rft.aufirst=LA&rft.au=Grego-Bessa%2C+J&rft.au=Raya%2C+A&rft.au=Bertr%C3%A1n%2C+E&rft.au=P%C3%A9rez-Pomares%2C+JM&rft.au=D%C3%ADez%2C+J&rft.au=Aranda%2C+S&rft.au=Palomo%2C+S&rft.au=McCormick%2C+F&rft.au=Izpis%C3%BAa-Belmonte%2C+JC&rft.au=de+la+Pompa%2C+JL&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC314285&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-92"><a href="#cite_ref-92">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCrosbyFlemingArgravesCorada2005" class="citation journal cs1">Crosby CV, Fleming PA, Argraves WS, Corada M, Zanetta L, Dejana E, Drake CJ (April 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2004-06-2244">"VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly"</a>. Blood. 105 (7): 2771–2776. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2004-06-2244">10.1182/blood-2004-06-2244</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15604224">15604224</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=VE-cadherin+is+not+required+for+the+formation+of+nascent+blood+vessels+but+acts+to+prevent+their+disassembly&rft.volume=105&rft.issue=7&rft.pages=2771-2776&rft.date=2005-04&rft_id=info%3Adoi%2F10.1182%2Fblood-2004-06-2244&rft_id=info%3Apmid%2F15604224&rft.aulast=Crosby&rft.aufirst=CV&rft.au=Fleming%2C+PA&rft.au=Argraves%2C+WS&rft.au=Corada%2C+M&rft.au=Zanetta%2C+L&rft.au=Dejana%2C+E&rft.au=Drake%2C+CJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood-2004-06-2244&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-93"><a href="#cite_ref-93">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNosedaMcLeanNiessenChang2004" class="citation journal cs1">Noseda M, McLean G, Niessen K, Chang L, Pollet I, Montpetit R, et al. (April 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.RES.0000124300.76171.C9">"Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation"</a>. Circulation Research. 94 (7): 910–917. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.RES.0000124300.76171.C9">10.1161/01.RES.0000124300.76171.C9</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14988227">14988227</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Circulation+Research&rft.atitle=Notch+activation+results+in+phenotypic+and+functional+changes+consistent+with+endothelial-to-mesenchymal+transformation&rft.volume=94&rft.issue=7&rft.pages=910-917&rft.date=2004-04&rft_id=info%3Adoi%2F10.1161%2F01.RES.0000124300.76171.C9&rft_id=info%3Apmid%2F14988227&rft.aulast=Noseda&rft.aufirst=M&rft.au=McLean%2C+G&rft.au=Niessen%2C+K&rft.au=Chang%2C+L&rft.au=Pollet%2C+I&rft.au=Montpetit%2C+R&rft.au=Shahidi%2C+R&rft.au=Dorovini-Zis%2C+K&rft.au=Li%2C+L&rft.au=Beckstead%2C+B&rft.au=Durand%2C+RE&rft.au=Hoodless%2C+PA&rft.au=Karsan%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1161%252F01.RES.0000124300.76171.C9&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-94"><a href="#cite_ref-94">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRonesMcLaughlinRaffinMercola2000" class="citation journal cs1">Rones MS, McLaughlin KA, Raffin M, Mercola M (September 2000). "Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis". Development. 127 (17): 3865–3876. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.127.17.3865">10.1242/dev.127.17.3865</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10934030">10934030</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Serrate+and+Notch+specify+cell+fates+in+the+heart+field+by+suppressing+cardiomyogenesis&rft.volume=127&rft.issue=17&rft.pages=3865-3876&rft.date=2000-09&rft_id=info%3Adoi%2F10.1242%2Fdev.127.17.3865&rft_id=info%3Apmid%2F10934030&rft.aulast=Rones&rft.aufirst=MS&rft.au=McLaughlin%2C+KA&rft.au=Raffin%2C+M&rft.au=Mercola%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-95"><a href="#cite_ref-95">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNemirCroqueloisPedrazziniRadtke2006" class="citation journal cs1">Nemir M, Croquelois A, Pedrazzini T, Radtke F (June 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.RES.0000226497.52052.2a">"Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling"</a>. Circulation Research. 98 (12): 1471–1478. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.RES.0000226497.52052.2a">10.1161/01.RES.0000226497.52052.2a</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16690879">16690879</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Circulation+Research&rft.atitle=Induction+of+cardiogenesis+in+embryonic+stem+cells+via+downregulation+of+Notch1+signaling&rft.volume=98&rft.issue=12&rft.pages=1471-1478&rft.date=2006-06&rft_id=info%3Adoi%2F10.1161%2F01.RES.0000226497.52052.2a&rft_id=info%3Apmid%2F16690879&rft.aulast=Nemir&rft.aufirst=M&rft.au=Croquelois%2C+A&rft.au=Pedrazzini%2C+T&rft.au=Radtke%2C+F&rft_id=https%3A%2F%2Fdoi.org%2F10.1161%252F01.RES.0000226497.52052.2a&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-96"><a href="#cite_ref-96">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCroqueloisDomenighettiNemirLepore2008" class="citation journal cs1">Croquelois A, Domenighetti AA, Nemir M, Lepore M, Rosenblatt-Velin N, Radtke F, Pedrazzini T (December 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605223">"Control of the adaptive response of the heart to stress via the Notch1 receptor pathway"</a>. The Journal of Experimental Medicine. 205 (13): 3173–3185. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1084%2Fjem.20081427">10.1084/jem.20081427</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605223">2605223</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19064701">19064701</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Experimental+Medicine&rft.atitle=Control+of+the+adaptive+response+of+the+heart+to+stress+via+the+Notch1+receptor+pathway&rft.volume=205&rft.issue=13&rft.pages=3173-3185&rft.date=2008-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2605223%23id-name%3DPMC&rft_id=info%3Apmid%2F19064701&rft_id=info%3Adoi%2F10.1084%2Fjem.20081427&rft.aulast=Croquelois&rft.aufirst=A&rft.au=Domenighetti%2C+AA&rft.au=Nemir%2C+M&rft.au=Lepore%2C+M&rft.au=Rosenblatt-Velin%2C+N&rft.au=Radtke%2C+F&rft.au=Pedrazzini%2C+T&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2605223&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-97"><a href="#cite_ref-97">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCollesiZentilinSinagraGiacca2008" class="citation journal cs1">Collesi C, Zentilin L, Sinagra G, Giacca M (October 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557047">"Notch1 signaling stimulates proliferation of immature cardiomyocytes"</a>. The Journal of Cell Biology. 183 (1): 117–128. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.200806091">10.1083/jcb.200806091</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557047">2557047</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18824567">18824567</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Cell+Biology&rft.atitle=Notch1+signaling+stimulates+proliferation+of+immature+cardiomyocytes&rft.volume=183&rft.issue=1&rft.pages=117-128&rft.date=2008-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2557047%23id-name%3DPMC&rft_id=info%3Apmid%2F18824567&rft_id=info%3Adoi%2F10.1083%2Fjcb.200806091&rft.aulast=Collesi&rft.aufirst=C&rft.au=Zentilin%2C+L&rft.au=Sinagra%2C+G&rft.au=Giacca%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2557047&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-98"><a href="#cite_ref-98">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCampaGutiérrez-LanzaCerignoliDíaz-Trelles2008" class="citation journal cs1">Campa VM, Gutiérrez-Lanza R, Cerignoli F, Díaz-Trelles R, Nelson B, Tsuji T, et al. (October 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557048">"Notch activates cell cycle reentry and progression in quiescent cardiomyocytes"</a>. The Journal of Cell Biology. 183 (1): 129–141. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.200806104">10.1083/jcb.200806104</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557048">2557048</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18838555">18838555</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Cell+Biology&rft.atitle=Notch+activates+cell+cycle+reentry+and+progression+in+quiescent+cardiomyocytes&rft.volume=183&rft.issue=1&rft.pages=129-141&rft.date=2008-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2557048%23id-name%3DPMC&rft_id=info%3Apmid%2F18838555&rft_id=info%3Adoi%2F10.1083%2Fjcb.200806104&rft.aulast=Campa&rft.aufirst=VM&rft.au=Guti%C3%A9rrez-Lanza%2C+R&rft.au=Cerignoli%2C+F&rft.au=D%C3%ADaz-Trelles%2C+R&rft.au=Nelson%2C+B&rft.au=Tsuji%2C+T&rft.au=Barcova%2C+M&rft.au=Jiang%2C+W&rft.au=Mercola%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2557048&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-99"><a href="#cite_ref-99">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhaoBorikovaBen-YairGuner-Ataman2014" class="citation journal cs1">Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, MacRae CA, Lee RT, et al. (January 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910613">"Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration"</a>. Proceedings of the National Academy of Sciences of the United States of America. 111 (4): 1403–1408. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2014PNAS..111.1403Z">2014PNAS..111.1403Z</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.1311705111">10.1073/pnas.1311705111</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910613">3910613</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24474765">24474765</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Notch+signaling+regulates+cardiomyocyte+proliferation+during+zebrafish+heart+regeneration&rft.volume=111&rft.issue=4&rft.pages=1403-1408&rft.date=2014-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3910613%23id-name%3DPMC&rft_id=info%3Apmid%2F24474765&rft_id=info%3Adoi%2F10.1073%2Fpnas.1311705111&rft_id=info%3Abibcode%2F2014PNAS..111.1403Z&rft.aulast=Zhao&rft.aufirst=L&rft.au=Borikova%2C+AL&rft.au=Ben-Yair%2C+R&rft.au=Guner-Ataman%2C+B&rft.au=MacRae%2C+CA&rft.au=Lee%2C+RT&rft.au=Burns%2C+CG&rft.au=Burns%2C+CE&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3910613&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-100"><a href="#cite_ref-100">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTeske" class="citation web cs1">Teske CM. <a rel="nofollow" class="external text" href="https://www.researchgate.net/publication/362704455">"An Evolving Role for Notch Signaling in Heart Regeneration of the Zebrafish Danio rerio"</a>. Researchgate.com. Retrieved 4 October 2022.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Researchgate.com&rft.atitle=An+Evolving+Role+for+Notch+Signaling+in+Heart+Regeneration+of+the+Zebrafish+Danio+rerio&rft.aulast=Teske&rft.aufirst=CM&rft_id=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F362704455&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-101"><a href="#cite_ref-101">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWangSridurongritDudasThomas2005" class="citation journal cs1">Wang J, Sridurongrit S, Dudas M, Thomas P, Nagy A, Schneider MD, et al. (October 2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361261">"Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart"</a>. Developmental Biology. 286 (1): 299–310. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ydbio.2005.07.035">10.1016/j.ydbio.2005.07.035</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361261">1361261</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16140292">16140292</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Biology&rft.atitle=Atrioventricular+cushion+transformation+is+mediated+by+ALK2+in+the+developing+mouse+heart&rft.volume=286&rft.issue=1&rft.pages=299-310&rft.date=2005-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1361261%23id-name%3DPMC&rft_id=info%3Apmid%2F16140292&rft_id=info%3Adoi%2F10.1016%2Fj.ydbio.2005.07.035&rft.aulast=Wang&rft.aufirst=J&rft.au=Sridurongrit%2C+S&rft.au=Dudas%2C+M&rft.au=Thomas%2C+P&rft.au=Nagy%2C+A&rft.au=Schneider%2C+MD&rft.au=Epstein%2C+JA&rft.au=Kaartinen%2C+V&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1361261&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-102"><a href="#cite_ref-102">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFXinSmallvan_RooijQi2007" class="citation journal cs1">Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Srivastava D, et al. (May 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876557">"Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function"</a>. Proceedings of the National Academy of Sciences of the United States of America. 104 (19): 7975–7980. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2007PNAS..104.7975X">2007PNAS..104.7975X</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.0702447104">10.1073/pnas.0702447104</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876557">1876557</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17468400">17468400</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Essential+roles+of+the+bHLH+transcription+factor+Hrt2+in+repression+of+atrial+gene+expression+and+maintenance+of+postnatal+cardiac+function&rft.volume=104&rft.issue=19&rft.pages=7975-7980&rft.date=2007-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1876557%23id-name%3DPMC&rft_id=info%3Apmid%2F17468400&rft_id=info%3Adoi%2F10.1073%2Fpnas.0702447104&rft_id=info%3Abibcode%2F2007PNAS..104.7975X&rft.aulast=Xin&rft.aufirst=M&rft.au=Small%2C+EM&rft.au=van+Rooij%2C+E&rft.au=Qi%2C+X&rft.au=Richardson%2C+JA&rft.au=Srivastava%2C+D&rft.au=Nakagawa%2C+O&rft.au=Olson%2C+EN&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1876557&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-103"><a href="#cite_ref-103">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHighZhangProwellerTu2007" class="citation journal cs1">High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA (February 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783803">"An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation"</a>. The Journal of Clinical Investigation. 117 (2): 353–363. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1172%2FJCI30070">10.1172/JCI30070</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783803">1783803</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17273555">17273555</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Clinical+Investigation&rft.atitle=An+essential+role+for+Notch+in+neural+crest+during+cardiovascular+development+and+smooth+muscle+differentiation&rft.volume=117&rft.issue=2&rft.pages=353-363&rft.date=2007-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1783803%23id-name%3DPMC&rft_id=info%3Apmid%2F17273555&rft_id=info%3Adoi%2F10.1172%2FJCI30070&rft.aulast=High&rft.aufirst=FA&rft.au=Zhang%2C+M&rft.au=Proweller%2C+A&rft.au=Tu%2C+L&rft.au=Parmacek%2C+MS&rft.au=Pear%2C+WS&rft.au=Epstein%2C+JA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1783803&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-104"><a href="#cite_ref-104">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHellströmPhngHofmannWallgard2007" class="citation journal cs1">Hellström M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, et al. (February 2007). "Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis". Nature. 445 (7129): 776–780. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2007Natur.445..776H">2007Natur.445..776H</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature05571">10.1038/nature05571</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17259973">17259973</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4407198">4407198</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Dll4+signalling+through+Notch1+regulates+formation+of+tip+cells+during+angiogenesis&rft.volume=445&rft.issue=7129&rft.pages=776-780&rft.date=2007-02&rft_id=info%3Adoi%2F10.1038%2Fnature05571&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4407198%23id-name%3DS2CID&rft_id=info%3Apmid%2F17259973&rft_id=info%3Abibcode%2F2007Natur.445..776H&rft.aulast=Hellstr%C3%B6m&rft.aufirst=M&rft.au=Phng%2C+LK&rft.au=Hofmann%2C+JJ&rft.au=Wallgard%2C+E&rft.au=Coultas%2C+L&rft.au=Lindblom%2C+P&rft.au=Alva%2C+J&rft.au=Nilsson%2C+AK&rft.au=Karlsson%2C+L&rft.au=Gaiano%2C+N&rft.au=Yoon%2C+K&rft.au=Rossant%2C+J&rft.au=Iruela-Arispe%2C+ML&rft.au=Kal%C3%A9n%2C+M&rft.au=Gerhardt%2C+H&rft.au=Betsholtz%2C+C&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid17251261-105"><a href="#cite_ref-pmid17251261_105-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLeslieAriza-McNaughtonBermangeMcAdow2007" class="citation journal cs1">Leslie JD, Ariza-McNaughton L, Bermange AL, McAdow R, Johnson SL, Lewis J (March 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.003244">"Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis"</a>. Development. 134 (5): 839–844. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.003244">10.1242/dev.003244</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17251261">17251261</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Endothelial+signalling+by+the+Notch+ligand+Delta-like+4+restricts+angiogenesis&rft.volume=134&rft.issue=5&rft.pages=839-844&rft.date=2007-03&rft_id=info%3Adoi%2F10.1242%2Fdev.003244&rft_id=info%3Apmid%2F17251261&rft.aulast=Leslie&rft.aufirst=JD&rft.au=Ariza-McNaughton%2C+L&rft.au=Bermange%2C+AL&rft.au=McAdow%2C+R&rft.au=Johnson%2C+SL&rft.au=Lewis%2C+J&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fdev.003244&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-106"><a href="#cite_ref-106">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLobovRenardPapadopoulosGale2007" class="citation journal cs1">Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD, Wiegand SJ (February 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805530">"Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting"</a>. Proceedings of the National Academy of Sciences of the United States of America. 104 (9): 3219–3224. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2007PNAS..104.3219L">2007PNAS..104.3219L</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.0611206104">10.1073/pnas.0611206104</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805530">1805530</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17296940">17296940</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Delta-like+ligand+4+%28Dll4%29+is+induced+by+VEGF+as+a+negative+regulator+of+angiogenic+sprouting&rft.volume=104&rft.issue=9&rft.pages=3219-3224&rft.date=2007-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1805530%23id-name%3DPMC&rft_id=info%3Apmid%2F17296940&rft_id=info%3Adoi%2F10.1073%2Fpnas.0611206104&rft_id=info%3Abibcode%2F2007PNAS..104.3219L&rft.aulast=Lobov&rft.aufirst=IB&rft.au=Renard%2C+RA&rft.au=Papadopoulos%2C+N&rft.au=Gale%2C+NW&rft.au=Thurston%2C+G&rft.au=Yancopoulos%2C+GD&rft.au=Wiegand%2C+SJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1805530&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid17259972-107"><a href="#cite_ref-pmid17259972_107-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSiekmannLawson2007" class="citation journal cs1">Siekmann AF, Lawson ND (February 2007). "Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries". Nature. 445 (7129): 781–784. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2007Natur.445..781S">2007Natur.445..781S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature05577">10.1038/nature05577</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17259972">17259972</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4349541">4349541</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Notch+signalling+limits+angiogenic+cell+behaviour+in+developing+zebrafish+arteries&rft.volume=445&rft.issue=7129&rft.pages=781-784&rft.date=2007-02&rft_id=info%3Adoi%2F10.1038%2Fnature05577&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4349541%23id-name%3DS2CID&rft_id=info%3Apmid%2F17259972&rft_id=info%3Abibcode%2F2007Natur.445..781S&rft.aulast=Siekmann&rft.aufirst=AF&rft.au=Lawson%2C+ND&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Siekmann_2007-108">^ <a href="#cite_ref-Siekmann_2007_108-0">a</a> <a href="#cite_ref-Siekmann_2007_108-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSiekmannLawson2007" class="citation journal cs1">Siekmann AF, Lawson ND (2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633979">"Notch signalling and the regulation of angiogenesis"</a>. Cell Adhesion & Migration. 1 (2): 104–106. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcam.1.2.4488">10.4161/cam.1.2.4488</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633979">2633979</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19329884">19329884</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell+Adhesion+%26+Migration&rft.atitle=Notch+signalling+and+the+regulation+of+angiogenesis&rft.volume=1&rft.issue=2&rft.pages=104-106&rft.date=2007&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2633979%23id-name%3DPMC&rft_id=info%3Apmid%2F19329884&rft_id=info%3Adoi%2F10.4161%2Fcam.1.2.4488&rft.aulast=Siekmann&rft.aufirst=AF&rft.au=Lawson%2C+ND&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2633979&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid11166270-109"><a href="#cite_ref-pmid11166270_109-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZacharyGliki2001" class="citation journal cs1">Zachary I, Gliki G (February 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0008-6363%2800%2900268-6">"Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family"</a>. Cardiovascular Research. 49 (3): 568–581. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0008-6363%2800%2900268-6">10.1016/S0008-6363(00)00268-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11166270">11166270</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cardiovascular+Research&rft.atitle=Signaling+transduction+mechanisms+mediating+biological+actions+of+the+vascular+endothelial+growth+factor+family&rft.volume=49&rft.issue=3&rft.pages=568-581&rft.date=2001-02&rft_id=info%3Adoi%2F10.1016%2FS0008-6363%2800%2900268-6&rft_id=info%3Apmid%2F11166270&rft.aulast=Zachary&rft.aufirst=I&rft.au=Gliki%2C+G&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0008-6363%252800%252900268-6&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid16219802-110"><a href="#cite_ref-pmid16219802_110-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWilliamsLiMurgaHarris2006" class="citation journal cs1">Williams CK, Li JL, Murga M, Harris AL, Tosato G (February 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895896">"Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function"</a>. Blood. 107 (3): 931–939. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2005-03-1000">10.1182/blood-2005-03-1000</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895896">1895896</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16219802">16219802</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Up-regulation+of+the+Notch+ligand+Delta-like+4+inhibits+VEGF-induced+endothelial+cell+function&rft.volume=107&rft.issue=3&rft.pages=931-939&rft.date=2006-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1895896%23id-name%3DPMC&rft_id=info%3Apmid%2F16219802&rft_id=info%3Adoi%2F10.1182%2Fblood-2005-03-1000&rft.aulast=Williams&rft.aufirst=CK&rft.au=Li%2C+JL&rft.au=Murga%2C+M&rft.au=Harris%2C+AL&rft.au=Tosato%2C+G&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1895896&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-111"><a href="#cite_ref-111">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLawsonScheerPhamKim2001" class="citation journal cs1">Lawson ND, Scheer N, Pham VN, Kim CH, Chitnis AB, Campos-Ortega JA, Weinstein BM (October 2001). "Notch signaling is required for arterial-venous differentiation during embryonic vascular development". Development. 128 (19): 3675–3683. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.128.19.3675">10.1242/dev.128.19.3675</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11585794">11585794</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Notch+signaling+is+required+for+arterial-venous+differentiation+during+embryonic+vascular+development&rft.volume=128&rft.issue=19&rft.pages=3675-3683&rft.date=2001-10&rft_id=info%3Adoi%2F10.1242%2Fdev.128.19.3675&rft_id=info%3Apmid%2F11585794&rft.aulast=Lawson&rft.aufirst=ND&rft.au=Scheer%2C+N&rft.au=Pham%2C+VN&rft.au=Kim%2C+CH&rft.au=Chitnis%2C+AB&rft.au=Campos-Ortega%2C+JA&rft.au=Weinstein%2C+BM&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid10476967-112"><a href="#cite_ref-pmid10476967_112-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFApelqvistLiSommerBeatus1999" class="citation journal cs1">Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, et al. (August 1999). "Notch signalling controls pancreatic cell differentiation". Nature. 400 (6747): 877–881. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1999Natur.400..877A">1999Natur.400..877A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F23716">10.1038/23716</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10476967">10476967</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4338027">4338027</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Notch+signalling+controls+pancreatic+cell+differentiation&rft.volume=400&rft.issue=6747&rft.pages=877-881&rft.date=1999-08&rft_id=info%3Adoi%2F10.1038%2F23716&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4338027%23id-name%3DS2CID&rft_id=info%3Apmid%2F10476967&rft_id=info%3Abibcode%2F1999Natur.400..877A&rft.aulast=Apelqvist&rft.aufirst=A&rft.au=Li%2C+H&rft.au=Sommer%2C+L&rft.au=Beatus%2C+P&rft.au=Anderson%2C+DJ&rft.au=Honjo%2C+T&rft.au=Hrabe+de+Angelis%2C+M&rft.au=Lendahl%2C+U&rft.au=Edlund%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid10842072-113"><a href="#cite_ref-pmid10842072_113-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLammertBrownMelton2000" class="citation journal cs1">Lammert E, Brown J, Melton DA (June 2000). "Notch gene expression during pancreatic organogenesis". Mechanisms of Development. 94 (1–2): 199–203. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0925-4773%2800%2900317-8">10.1016/S0925-4773(00)00317-8</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10842072">10842072</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9931966">9931966</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mechanisms+of+Development&rft.atitle=Notch+gene+expression+during+pancreatic+organogenesis&rft.volume=94&rft.issue=1%E2%80%932&rft.pages=199-203&rft.date=2000-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A9931966%23id-name%3DS2CID&rft_id=info%3Apmid%2F10842072&rft_id=info%3Adoi%2F10.1016%2FS0925-4773%2800%2900317-8&rft.aulast=Lammert&rft.aufirst=E&rft.au=Brown%2C+J&rft.au=Melton%2C+DA&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid12941629-114"><a href="#cite_ref-pmid12941629_114-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFieldDongBeisStainier2003" class="citation journal cs1">Field HA, Dong PD, Beis D, Stainier DY (September 2003). "Formation of the digestive system in zebrafish. II. Pancreas morphogenesis". Developmental Biology. 261 (1): 197–208. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0012-1606%2803%2900308-7">10.1016/S0012-1606(03)00308-7</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12941629">12941629</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Biology&rft.atitle=Formation+of+the+digestive+system+in+zebrafish.+II.+Pancreas+morphogenesis&rft.volume=261&rft.issue=1&rft.pages=197-208&rft.date=2003-09&rft_id=info%3Adoi%2F10.1016%2FS0012-1606%2803%2900308-7&rft_id=info%3Apmid%2F12941629&rft.aulast=Field&rft.aufirst=HA&rft.au=Dong%2C+PD&rft.au=Beis%2C+D&rft.au=Stainier%2C+DY&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid10615124-115"><a href="#cite_ref-pmid10615124_115-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJensenPedersenGalanteHald2000" class="citation journal cs1">Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, et al. (January 2000). "Control of endodermal endocrine development by Hes-1". Nature Genetics. 24 (1): 36–44. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F71657">10.1038/71657</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10615124">10615124</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:52872659">52872659</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=Control+of+endodermal+endocrine+development+by+Hes-1&rft.volume=24&rft.issue=1&rft.pages=36-44&rft.date=2000-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A52872659%23id-name%3DS2CID&rft_id=info%3Apmid%2F10615124&rft_id=info%3Adoi%2F10.1038%2F71657&rft.aulast=Jensen&rft.aufirst=J&rft.au=Pedersen%2C+EE&rft.au=Galante%2C+P&rft.au=Hald%2C+J&rft.au=Heller%2C+RS&rft.au=Ishibashi%2C+M&rft.au=Kageyama%2C+R&rft.au=Guillemot%2C+F&rft.au=Serup%2C+P&rft.au=Madsen%2C+OD&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid14699589-116"><a href="#cite_ref-pmid14699589_116-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJensen2004" class="citation journal cs1">Jensen J (January 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fdvdy.10460">"Gene regulatory factors in pancreatic development"</a>. Developmental Dynamics. 229 (1): 176–200. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fdvdy.10460">10.1002/dvdy.10460</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14699589">14699589</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Dynamics&rft.atitle=Gene+regulatory+factors+in+pancreatic+development&rft.volume=229&rft.issue=1&rft.pages=176-200&rft.date=2004-01&rft_id=info%3Adoi%2F10.1002%2Fdvdy.10460&rft_id=info%3Apmid%2F14699589&rft.aulast=Jensen&rft.aufirst=J&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252Fdvdy.10460&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid14651921-117"><a href="#cite_ref-pmid14651921_117-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNorgaardJensenJensen2003" class="citation journal cs1">Norgaard GA, Jensen JN, Jensen J (December 2003). <a href="/wiki/Pancreatic_Progenitor_Cell" class="mw-redirect" title="Pancreatic Progenitor Cell">"FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development"</a>. Developmental Biology. 264 (2): 323–338. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ydbio.2003.08.013">10.1016/j.ydbio.2003.08.013</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14651921">14651921</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Biology&rft.atitle=FGF10+signaling+maintains+the+pancreatic+progenitor+cell+state+revealing+a+novel+role+of+Notch+in+organ+development&rft.volume=264&rft.issue=2&rft.pages=323-338&rft.date=2003-12&rft_id=info%3Adoi%2F10.1016%2Fj.ydbio.2003.08.013&rft_id=info%3Apmid%2F14651921&rft.aulast=Norgaard&rft.aufirst=GA&rft.au=Jensen%2C+JN&rft.au=Jensen%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Crosnier_2005-118">^ <a href="#cite_ref-Crosnier_2005_118-0">a</a> <a href="#cite_ref-Crosnier_2005_118-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCrosnierVargessonGschmeissnerAriza-McNaughton2005" class="citation journal cs1">Crosnier C, Vargesson N, Gschmeissner S, Ariza-McNaughton L, Morrison A, Lewis J (March 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.01644">"Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine"</a>. Development. 132 (5): 1093–1104. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.01644">10.1242/dev.01644</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15689380">15689380</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Delta-Notch+signalling+controls+commitment+to+a+secretory+fate+in+the+zebrafish+intestine&rft.volume=132&rft.issue=5&rft.pages=1093-1104&rft.date=2005-03&rft_id=info%3Adoi%2F10.1242%2Fdev.01644&rft_id=info%3Apmid%2F15689380&rft.aulast=Crosnier&rft.aufirst=C&rft.au=Vargesson%2C+N&rft.au=Gschmeissner%2C+S&rft.au=Ariza-McNaughton%2C+L&rft.au=Morrison%2C+A&rft.au=Lewis%2C+J&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fdev.01644&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-119"><a href="#cite_ref-119">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYamadaYamazakiYamaneYoshino2003" class="citation journal cs1">Yamada T, Yamazaki H, Yamane T, Yoshino M, Okuyama H, Tsuneto M, et al. (March 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2002-06-1740">"Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells"</a>. Blood. 101 (6): 2227–2234. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2002-06-1740">10.1182/blood-2002-06-1740</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12411305">12411305</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Regulation+of+osteoclast+development+by+Notch+signaling+directed+to+osteoclast+precursors+and+through+stromal+cells&rft.volume=101&rft.issue=6&rft.pages=2227-2234&rft.date=2003-03&rft_id=info%3Adoi%2F10.1182%2Fblood-2002-06-1740&rft_id=info%3Apmid%2F12411305&rft.aulast=Yamada&rft.aufirst=T&rft.au=Yamazaki%2C+H&rft.au=Yamane%2C+T&rft.au=Yoshino%2C+M&rft.au=Okuyama%2C+H&rft.au=Tsuneto%2C+M&rft.au=Kurino%2C+T&rft.au=Hayashi%2C+S&rft.au=Sakano%2C+S&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood-2002-06-1740&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-120"><a href="#cite_ref-120">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWatanabeTezukaMatsunoMiyatani2003" class="citation journal cs1">Watanabe N, Tezuka Y, Matsuno K, Miyatani S, Morimura N, Yasuda M, et al. (2003). "Suppression of differentiation and proliferation of early chondrogenic cells by Notch". Journal of Bone and Mineral Metabolism. 21 (6): 344–352. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00774-003-0428-4">10.1007/s00774-003-0428-4</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14586790">14586790</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:1881239">1881239</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Bone+and+Mineral+Metabolism&rft.atitle=Suppression+of+differentiation+and+proliferation+of+early+chondrogenic+cells+by+Notch&rft.volume=21&rft.issue=6&rft.pages=344-352&rft.date=2003&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A1881239%23id-name%3DS2CID&rft_id=info%3Apmid%2F14586790&rft_id=info%3Adoi%2F10.1007%2Fs00774-003-0428-4&rft.aulast=Watanabe&rft.aufirst=N&rft.au=Tezuka%2C+Y&rft.au=Matsuno%2C+K&rft.au=Miyatani%2C+S&rft.au=Morimura%2C+N&rft.au=Yasuda%2C+M&rft.au=Fujimaki%2C+R&rft.au=Kuroda%2C+K&rft.au=Hiraki%2C+Y&rft.au=Hozumi%2C+N&rft.au=Tezuka%2C+K&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-121"><a href="#cite_ref-121">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGöthertBrakeSmeetsDührsen2007" class="citation journal cs1">Göthert JR, Brake RL, Smeets M, Dührsen U, Begley CG, Izon DJ (November 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2006-12-063644">"NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis"</a>. Blood. 110 (10): 3753–3762. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2006-12-063644">10.1182/blood-2006-12-063644</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17698635">17698635</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=NOTCH1+pathway+activation+is+an+early+hallmark+of+SCL+T+leukemogenesis&rft.volume=110&rft.issue=10&rft.pages=3753-3762&rft.date=2007-11&rft_id=info%3Adoi%2F10.1182%2Fblood-2006-12-063644&rft_id=info%3Apmid%2F17698635&rft.aulast=G%C3%B6thert&rft.aufirst=JR&rft.au=Brake%2C+RL&rft.au=Smeets%2C+M&rft.au=D%C3%BChrsen%2C+U&rft.au=Begley%2C+CG&rft.au=Izon%2C+DJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood-2006-12-063644&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-122"><a href="#cite_ref-122">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWengFerrandoLeeMorris2004" class="citation journal cs1">Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, et al. (October 2004). "Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia". Science. 306 (5694): 269–271. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2004Sci...306..269W">2004Sci...306..269W</a>. <a href="/wiki/CiteSeerX_(identifier)" class="mw-redirect" title="CiteSeerX (identifier)">CiteSeerX</a> <a rel="nofollow" class="external text" href="https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.459.5126">10.1.1.459.5126</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.1102160">10.1126/science.1102160</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15472075">15472075</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:24049536">24049536</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Activating+mutations+of+NOTCH1+in+human+T+cell+acute+lymphoblastic+leukemia&rft.volume=306&rft.issue=5694&rft.pages=269-271&rft.date=2004-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A24049536%23id-name%3DS2CID&rft_id=info%3Abibcode%2F2004Sci...306..269W&rft_id=https%3A%2F%2Fciteseerx.ist.psu.edu%2Fviewdoc%2Fsummary%3Fdoi%3D10.1.1.459.5126%23id-name%3DCiteSeerX&rft_id=info%3Apmid%2F15472075&rft_id=info%3Adoi%2F10.1126%2Fscience.1102160&rft.aulast=Weng&rft.aufirst=AP&rft.au=Ferrando%2C+AA&rft.au=Lee%2C+W&rft.au=Morris%2C+JP&rft.au=Silverman%2C+LB&rft.au=Sanchez-Irizarry%2C+C&rft.au=Blacklow%2C+SC&rft.au=Look%2C+AT&rft.au=Aster%2C+JC&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-123"><a href="#cite_ref-123">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPalomeroLimOdomSulis2006" class="citation journal cs1">Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, et al. (November 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838740">"NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth"</a>. Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18261–18266. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2006PNAS..10318261P">2006PNAS..10318261P</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.0606108103">10.1073/pnas.0606108103</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838740">1838740</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17114293">17114293</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=NOTCH1+directly+regulates+c-MYC+and+activates+a+feed-forward-loop+transcriptional+network+promoting+leukemic+cell+growth&rft.volume=103&rft.issue=48&rft.pages=18261-18266&rft.date=2006-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1838740%23id-name%3DPMC&rft_id=info%3Apmid%2F17114293&rft_id=info%3Adoi%2F10.1073%2Fpnas.0606108103&rft_id=info%3Abibcode%2F2006PNAS..10318261P&rft.aulast=Palomero&rft.aufirst=T&rft.au=Lim%2C+WK&rft.au=Odom%2C+DT&rft.au=Sulis%2C+ML&rft.au=Real%2C+PJ&rft.au=Margolin%2C+A&rft.au=Barnes%2C+KC&rft.au=O%27Neil%2C+J&rft.au=Neuberg%2C+D&rft.au=Weng%2C+AP&rft.au=Aster%2C+JC&rft.au=Sigaux%2C+F&rft.au=Soulier%2C+J&rft.au=Look%2C+AT&rft.au=Young%2C+RA&rft.au=Califano%2C+A&rft.au=Ferrando%2C+AA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1838740&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-124"><a href="#cite_ref-124">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRampiasVgenopoulouAvgerisPolyzos2014" class="citation journal cs1">Rampias T, Vgenopoulou P, Avgeris M, Polyzos A, Stravodimos K, Valavanis C, et al. (October 2014). "A new tumor suppressor role for the Notch pathway in bladder cancer". Nature Medicine. 20 (10): 1199–1205. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnm.3678">10.1038/nm.3678</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25194568">25194568</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:5390234">5390234</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=A+new+tumor+suppressor+role+for+the+Notch+pathway+in+bladder+cancer&rft.volume=20&rft.issue=10&rft.pages=1199-1205&rft.date=2014-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A5390234%23id-name%3DS2CID&rft_id=info%3Apmid%2F25194568&rft_id=info%3Adoi%2F10.1038%2Fnm.3678&rft.aulast=Rampias&rft.aufirst=T&rft.au=Vgenopoulou%2C+P&rft.au=Avgeris%2C+M&rft.au=Polyzos%2C+A&rft.au=Stravodimos%2C+K&rft.au=Valavanis%2C+C&rft.au=Scorilas%2C+A&rft.au=Klinakis%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-125"><a href="#cite_ref-125">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRistic_PetrovicStokanovićStojnevPotić_Floranović2022" class="citation journal cs1">Ristic Petrovic A, Stokanović D, Stojnev S, Potić Floranović M, Krstić M, Djordjević I, et al. (July 2022). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392971">"The association between NOTCH3 expression and the clinical outcome in the urothelial bladder cancer patients"</a>. Bosnian Journal of Basic Medical Sciences. 22 (4): 523–530. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.17305%2Fbjbms.2021.6767">10.17305/bjbms.2021.6767</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392971">9392971</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/35073251">35073251</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Bosnian+Journal+of+Basic+Medical+Sciences&rft.atitle=The+association+between+NOTCH3+expression+and+the+clinical+outcome+in+the+urothelial+bladder+cancer+patients&rft.volume=22&rft.issue=4&rft.pages=523-530&rft.date=2022-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9392971%23id-name%3DPMC&rft_id=info%3Apmid%2F35073251&rft_id=info%3Adoi%2F10.17305%2Fbjbms.2021.6767&rft.aulast=Ristic+Petrovic&rft.aufirst=A&rft.au=Stokanovi%C4%87%2C+D&rft.au=Stojnev%2C+S&rft.au=Poti%C4%87+Floranovi%C4%87%2C+M&rft.au=Krsti%C4%87%2C+M&rft.au=Djordjevi%C4%87%2C+I&rft.au=Skaki%C4%87%2C+A&rft.au=Jankovi%C4%87+Veli%C4%8Dkovi%C4%87%2C+L&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9392971&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-126"><a href="#cite_ref-126">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhangLiSchippersEimers2024" class="citation journal cs1">Zhang R, Li S, Schippers K, Eimers B, Niu J, Hornung BV, van den Hout MC, van Ijcken WF, Peppelenbosch MP, Smits R (June 2024). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161089">"Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines"</a>. PLOS ONE. 19 (6): e0304607. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pone.0304607">10.1371/journal.pone.0304607</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161089">11161089</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/38848383">38848383</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+ONE&rft.atitle=Unraveling+the+impact+of+AXIN1+mutations+on+HCC+development%3A+Insights+from+CRISPR%2FCas9+repaired+AXIN1-mutant+liver+cancer+cell+lines.&rft.volume=19&rft.issue=6&rft.pages=e0304607&rft.date=2024-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC11161089%23id-name%3DPMC&rft_id=info%3Apmid%2F38848383&rft_id=info%3Adoi%2F10.1371%2Fjournal.pone.0304607&rft.aulast=Zhang&rft.aufirst=R&rft.au=Li%2C+S&rft.au=Schippers%2C+K&rft.au=Eimers%2C+B&rft.au=Niu%2C+J&rft.au=Hornung%2C+BV&rft.au=van+den+Hout%2C+MC&rft.au=van+Ijcken%2C+WF&rft.au=Peppelenbosch%2C+MP&rft.au=Smits%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC11161089&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Purow2012-127"><a href="#cite_ref-Purow2012_127-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPurow2012" class="citation book cs1">Purow B (2012). "Notch Inhibition as a Promising New Approach to Cancer Therapy". Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology. Vol. 727. pp. 305–319. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2F978-1-4614-0899-4_23">10.1007/978-1-4614-0899-4_23</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4614-0898-7" title="Special:BookSources/978-1-4614-0898-7"><bdi>978-1-4614-0898-7</bdi></a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361718">3361718</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22399357">22399357</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Notch+Inhibition+as+a+Promising+New+Approach+to+Cancer+Therapy&rft.btitle=Notch+Signaling+in+Embryology+and+Cancer&rft.series=Advances+in+Experimental+Medicine+and+Biology&rft.pages=305-319&rft.date=2012&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3361718%23id-name%3DPMC&rft_id=info%3Apmid%2F22399357&rft_id=info%3Adoi%2F10.1007%2F978-1-4614-0899-4_23&rft.isbn=978-1-4614-0898-7&rft.aulast=Purow&rft.aufirst=B&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-EM2013-128"><a href="#cite_ref-EM2013_128-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEspinozaMiele2013" class="citation journal cs1">Espinoza I, Miele L (August 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732476">"Notch inhibitors for cancer treatment"</a>. Pharmacology & Therapeutics. 139 (2): 95–110. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pharmthera.2013.02.003">10.1016/j.pharmthera.2013.02.003</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732476">3732476</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23458608">23458608</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacology+%26+Therapeutics&rft.atitle=Notch+inhibitors+for+cancer+treatment&rft.volume=139&rft.issue=2&rft.pages=95-110&rft.date=2013-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3732476%23id-name%3DPMC&rft_id=info%3Apmid%2F23458608&rft_id=info%3Adoi%2F10.1016%2Fj.pharmthera.2013.02.003&rft.aulast=Espinoza&rft.aufirst=I&rft.au=Miele%2C+L&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3732476&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-MK-129"><a href="#cite_ref-MK_129-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20150205035222/https://oncology-central.com/content/news/notch-inhibitors-could-help-overcome-therapy-resistance-in-er-positive-breast-cancer">"Notch inhibitors could help overcome therapy resistance in ER-positive breast cancer"</a>. 2015. Archived from <a rel="nofollow" class="external text" href="https://oncology-central.com/content/news/notch-inhibitors-could-help-overcome-therapy-resistance-in-er-positive-breast-cancer">the original</a> on 2015-02-05. Retrieved 2015-02-05.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Notch+inhibitors+could+help+overcome+therapy+resistance+in+ER-positive+breast+cancer&rft.date=2015&rft_id=https%3A%2F%2Foncology-central.com%2Fcontent%2Fnews%2Fnotch-inhibitors-could-help-overcome-therapy-resistance-in-er-positive-breast-cancer&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-130"><a href="#cite_ref-130">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRamirez_WilliamsBrüggemannHubertAchmad2019" class="citation journal cs1">Ramirez Williams L, Brüggemann K, Hubert M, Achmad N, Kiesel L, Schäfer SD, et al. (December 2019). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Faogs.13707">"γ-Secretase inhibition affects viability, apoptosis, and the stem cell phenotype of endometriotic cells"</a>. Acta Obstetricia et Gynecologica Scandinavica. 98 (12): 1565–1574. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Faogs.13707">10.1111/aogs.13707</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31424097">31424097</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Acta+Obstetricia+et+Gynecologica+Scandinavica&rft.atitle=%CE%B3-Secretase+inhibition+affects+viability%2C+apoptosis%2C+and+the+stem+cell+phenotype+of+endometriotic+cells&rft.volume=98&rft.issue=12&rft.pages=1565-1574&rft.date=2019-12&rft_id=info%3Adoi%2F10.1111%2Faogs.13707&rft_id=info%3Apmid%2F31424097&rft.aulast=Ramirez+Williams&rft.aufirst=L&rft.au=Br%C3%BCggemann%2C+K&rft.au=Hubert%2C+M&rft.au=Achmad%2C+N&rft.au=Kiesel%2C+L&rft.au=Sch%C3%A4fer%2C+SD&rft.au=Greve%2C+B&rft.au=G%C3%B6tte%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1111%252Faogs.13707&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-131"><a href="#cite_ref-131">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchüringDahlhuesKorteKiesel2018" class="citation journal cs1">Schüring AN, Dahlhues B, Korte A, Kiesel L, Titze U, Heitkötter B, et al. (March 2018). <a rel="nofollow" class="external text" href="https://zenodo.org/record/3695800">"The endometrial stem cell markers notch-1 and numb are associated with endometriosis"</a>. Reproductive Biomedicine Online. 36 (3): 294–301. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.rbmo.2017.11.010">10.1016/j.rbmo.2017.11.010</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29398419">29398419</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4912558">4912558</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Reproductive+Biomedicine+Online&rft.atitle=The+endometrial+stem+cell+markers+notch-1+and+numb+are+associated+with+endometriosis&rft.volume=36&rft.issue=3&rft.pages=294-301&rft.date=2018-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4912558%23id-name%3DS2CID&rft_id=info%3Apmid%2F29398419&rft_id=info%3Adoi%2F10.1016%2Fj.rbmo.2017.11.010&rft.aulast=Sch%C3%BCring&rft.aufirst=AN&rft.au=Dahlhues%2C+B&rft.au=Korte%2C+A&rft.au=Kiesel%2C+L&rft.au=Titze%2C+U&rft.au=Heitk%C3%B6tter%2C+B&rft.au=Ruckert%2C+C&rft.au=G%C3%B6tte%2C+M&rft_id=https%3A%2F%2Fzenodo.org%2Frecord%2F3695800&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-132"><a href="#cite_ref-132">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGötteWolfStaeblerBuchweitz2008" class="citation journal cs1">Götte M, Wolf M, Staebler A, Buchweitz O, Kelsch R, Schüring AN, Kiesel L (July 2008). "Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma". The Journal of Pathology. 215 (3): 317–329. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fpath.2364">10.1002/path.2364</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18473332">18473332</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:206323361">206323361</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Pathology&rft.atitle=Increased+expression+of+the+adult+stem+cell+marker+Musashi-1+in+endometriosis+and+endometrial+carcinoma&rft.volume=215&rft.issue=3&rft.pages=317-329&rft.date=2008-07&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A206323361%23id-name%3DS2CID&rft_id=info%3Apmid%2F18473332&rft_id=info%3Adoi%2F10.1002%2Fpath.2364&rft.aulast=G%C3%B6tte&rft.aufirst=M&rft.au=Wolf%2C+M&rft.au=Staebler%2C+A&rft.au=Buchweitz%2C+O&rft.au=Kelsch%2C+R&rft.au=Sch%C3%BCring%2C+AN&rft.au=Kiesel%2C+L&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Erni_2021-133"><a href="#cite_ref-Erni_2021_133-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFErniGillPalaferriFernandes2021" class="citation journal cs1">Erni ST, Gill JC, Palaferri C, Fernandes G, Buri M, Lazarides K, et al. (13 August 2021). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414802">"Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors"</a>. Frontiers in Cell and Developmental Biology. 9. Frontiers Media SA: 710159. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3389%2Ffcell.2021.710159">10.3389/fcell.2021.710159</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414802">8414802</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/34485296">34485296</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Frontiers+in+Cell+and+Developmental+Biology&rft.atitle=Hair+Cell+Generation+in+Cochlear+Culture+Models+Mediated+by+Novel+%CE%B3-Secretase+Inhibitors&rft.volume=9&rft.pages=710159&rft.date=2021-08-13&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8414802%23id-name%3DPMC&rft_id=info%3Apmid%2F34485296&rft_id=info%3Adoi%2F10.3389%2Ffcell.2021.710159&rft.aulast=Erni&rft.aufirst=ST&rft.au=Gill%2C+JC&rft.au=Palaferri%2C+C&rft.au=Fernandes%2C+G&rft.au=Buri%2C+M&rft.au=Lazarides%2C+K&rft.au=Grandgirard%2C+D&rft.au=Edge%2C+AS&rft.au=Leib%2C+SL&rft.au=Roccio%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8414802&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Samarajeewa_2019-134"><a href="#cite_ref-Samarajeewa_2019_134-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSamarajeewaJacquesDabdoub2019" class="citation journal cs1">Samarajeewa A, Jacques BE, Dabdoub A (May 2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520458">"Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration"</a>. Molecular Therapy. 27 (5). Elsevier BV: 904–911. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ymthe.2019.03.017">10.1016/j.ymthe.2019.03.017</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520458">6520458</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30982678">30982678</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Therapeutic+Potential+of+Wnt+and+Notch+Signaling+and+Epigenetic+Regulation+in+Mammalian+Sensory+Hair+Cell+Regeneration&rft.volume=27&rft.issue=5&rft.pages=904-911&rft.date=2019-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6520458%23id-name%3DPMC&rft_id=info%3Apmid%2F30982678&rft_id=info%3Adoi%2F10.1016%2Fj.ymthe.2019.03.017&rft.aulast=Samarajeewa&rft.aufirst=A&rft.au=Jacques%2C+BE&rft.au=Dabdoub%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6520458&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-135"><a href="#cite_ref-135">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCollierMonkMainiLewis1996" class="citation journal cs1">Collier JR, Monk NA, Maini PK, Lewis JH (December 1996). <a rel="nofollow" class="external text" href="https://ora.ox.ac.uk/objects/uuid:d18e2570-90fd-47d5-94ad-3a4df1c0fe4c">"Pattern formation by lateral inhibition with feedback: a mathematical model of delta-notch intercellular signalling"</a>. Journal of Theoretical Biology. 183 (4): 429–446. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1996JThBi.183..429C">1996JThBi.183..429C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fjtbi.1996.0233">10.1006/jtbi.1996.0233</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9015458">9015458</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Theoretical+Biology&rft.atitle=Pattern+formation+by+lateral+inhibition+with+feedback%3A+a+mathematical+model+of+delta-notch+intercellular+signalling&rft.volume=183&rft.issue=4&rft.pages=429-446&rft.date=1996-12&rft_id=info%3Apmid%2F9015458&rft_id=info%3Adoi%2F10.1006%2Fjtbi.1996.0233&rft_id=info%3Abibcode%2F1996JThBi.183..429C&rft.aulast=Collier&rft.aufirst=JR&rft.au=Monk%2C+NA&rft.au=Maini%2C+PK&rft.au=Lewis%2C+JH&rft_id=https%3A%2F%2Fora.ox.ac.uk%2Fobjects%2Fuuid%3Ad18e2570-90fd-47d5-94ad-3a4df1c0fe4c&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-Berkemeier_2023-136">^ <a href="#cite_ref-Berkemeier_2023_136-0">a</a> <a href="#cite_ref-Berkemeier_2023_136-1">b</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBerkemeierPage2023" class="citation journal cs1">Berkemeier F, Page KM (June 2023). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.mbs.2023.109012">"Coupling dynamics of 2D Notch-Delta signalling"</a>. Mathematical Biosciences. 360: 109012. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.mbs.2023.109012">10.1016/j.mbs.2023.109012</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/37142213">37142213</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mathematical+Biosciences&rft.atitle=Coupling+dynamics+of+2D+Notch-Delta+signalling&rft.volume=360&rft.pages=109012&rft.date=2023-06&rft_id=info%3Adoi%2F10.1016%2Fj.mbs.2023.109012&rft_id=info%3Apmid%2F37142213&rft.aulast=Berkemeier&rft.aufirst=F&rft.au=Page%2C+KM&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.mbs.2023.109012&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-137"><a href="#cite_ref-137">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVasilopoulosPainter2016" class="citation journal cs1">Vasilopoulos G, Painter KJ (March 2016). "Pattern formation in discrete cell tissues under long range filopodia-based direct cell to cell contact". Mathematical Biosciences. 273: 1–15. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.mbs.2015.12.008">10.1016/j.mbs.2015.12.008</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26748293">26748293</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mathematical+Biosciences&rft.atitle=Pattern+formation+in+discrete+cell+tissues+under+long+range+filopodia-based+direct+cell+to+cell+contact&rft.volume=273&rft.pages=1-15&rft.date=2016-03&rft_id=info%3Adoi%2F10.1016%2Fj.mbs.2015.12.008&rft_id=info%3Apmid%2F26748293&rft.aulast=Vasilopoulos&rft.aufirst=G&rft.au=Painter%2C+KJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-138"><a href="#cite_ref-138">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEisen2010" class="citation web cs1">Eisen JS (2010-07-27). "Faculty Opinions recommendation of Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition". <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3410%2Ff.4361976.4187082">10.3410/f.4361976.4187082</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Faculty+Opinions+recommendation+of+Dynamic+filopodia+transmit+intermittent+Delta-Notch+signaling+to+drive+pattern+refinement+during+lateral+inhibition.&rft.date=2010-07-27&rft_id=info%3Adoi%2F10.3410%2Ff.4361976.4187082&rft.aulast=Eisen&rft.aufirst=JS&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> <code class="cs1-code">{{<a href="/wiki/Template:Cite_web" title="Template:Cite web">cite web</a>}}</code>: Missing or empty <code class="cs1-code">|url=</code> (<a href="/wiki/Help:CS1_errors#cite_web_url" title="Help:CS1 errors">help</a>) </li> <li id="cite_note-139"><a href="#cite_ref-139">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCohenBaumMiodownik2011" class="citation journal cs1">Cohen M, Baum B, Miodownik M (June 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104346">"The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling"</a>. Journal of the Royal Society, Interface. 8 (59): 787–798. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1098%2Frsif.2010.0488">10.1098/rsif.2010.0488</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104346">3104346</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21084342">21084342</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Society%2C+Interface&rft.atitle=The+importance+of+structured+noise+in+the+generation+of+self-organizing+tissue+patterns+through+contact-mediated+cell-cell+signalling&rft.volume=8&rft.issue=59&rft.pages=787-798&rft.date=2011-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3104346%23id-name%3DPMC&rft_id=info%3Apmid%2F21084342&rft_id=info%3Adoi%2F10.1098%2Frsif.2010.0488&rft.aulast=Cohen&rft.aufirst=M&rft.au=Baum%2C+B&rft.au=Miodownik%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3104346&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-140"><a href="#cite_ref-140">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBinshtokSprinzak2018" class="citation book cs1">Binshtok U, Sprinzak D (2018). "Modeling the Notch Response". In Borggrefe T, Giaimo B (eds.). Molecular Mechanisms of Notch Signaling. Advances in Experimental Medicine and Biology. Vol. 1066. Cham: Springer International Publishing. pp. 79–98. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2F978-3-319-89512-3_5">10.1007/978-3-319-89512-3_5</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-3-319-89512-3" title="Special:BookSources/978-3-319-89512-3"><bdi>978-3-319-89512-3</bdi></a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879322">6879322</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30030823">30030823</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Modeling+the+Notch+Response&rft.btitle=Molecular+Mechanisms+of+Notch+Signaling&rft.place=Cham&rft.series=Advances+in+Experimental+Medicine+and+Biology&rft.pages=79-98&rft.pub=Springer+International+Publishing&rft.date=2018&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6879322%23id-name%3DPMC&rft_id=info%3Apmid%2F30030823&rft_id=info%3Adoi%2F10.1007%2F978-3-319-89512-3_5&rft.isbn=978-3-319-89512-3&rft.aulast=Binshtok&rft.aufirst=U&rft.au=Sprinzak%2C+D&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> <li id="cite_note-pmid27226324-141"><a href="#cite_ref-pmid27226324_141-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHunterHadjivasiliouBoninHe2016" class="citation journal cs1">Hunter GL, Hadjivasiliou Z, Bonin H, He L, Perrimon N, Charras G, Baum B (July 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958321">"Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning"</a>. Development. 143 (13): 2305–2310. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fdev.134213">10.1242/dev.134213</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958321">4958321</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27226324">27226324</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Development&rft.atitle=Coordinated+control+of+Notch%2FDelta+signalling+and+cell+cycle+progression+drives+lateral+inhibition-mediated+tissue+patterning&rft.volume=143&rft.issue=13&rft.pages=2305-2310&rft.date=2016-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4958321%23id-name%3DPMC&rft_id=info%3Apmid%2F27226324&rft_id=info%3Adoi%2F10.1242%2Fdev.134213&rft.aulast=Hunter&rft.aufirst=GL&rft.au=Hadjivasiliou%2C+Z&rft.au=Bonin%2C+H&rft.au=He%2C+L&rft.au=Perrimon%2C+N&rft.au=Charras%2C+G&rft.au=Baum%2C+B&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4958321&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANotch+signaling+pathway" class="Z3988"> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2>[<a href="/w/index.php?title=Notch_signaling_pathway&action=edit&section=34" title="Edit section: External links">edit</a>]</div> <ul><li>Diagram: <a rel="nofollow" class="external text" href="https://web.archive.org/web/20070929120458/http://www.genome.jp/dbget-bin/get_pathway?org_name=hsa&mapno=04330">notch signaling pathway in Homo sapiens</a></li> <li>Diagram: <a rel="nofollow" class="external text" href="http://www.genome.jp/kegg/pathway/dme/dme04330.html">Notch signaling in Drosophila</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20171109152324/http://www.genome.jp/kegg/pathway/dme/dme04330.html">Archived</a> 2017-11-09 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Notch+Receptors">Notch+Receptors</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Cell_signaling_/_Signal_transduction" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Signal_transduction" title="Template:Signal transduction"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Signal_transduction" title="Template talk:Signal transduction"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Signal_transduction" title="Special:EditPage/Template:Signal transduction"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_signaling_/_Signal_transduction" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_signaling" title="Cell signaling">Cell signaling</a> / <a href="/wiki/Signal_transduction" title="Signal transduction">Signal transduction</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Signaling pathways</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">GPCR</a></li> <li class="mw-empty-elt"></li> <li><a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt</a></li> <li><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">RTK</a> <ul><li><a href="/wiki/TGF_beta_signaling_pathway" title="TGF beta signaling pathway">TGF beta</a></li> <li><a href="/wiki/MAPK/ERK_pathway" title="MAPK/ERK pathway">MAPK/ERK</a></li></ul></li> <li><a class="mw-selflink selflink">Notch</a></li> <li><a href="/wiki/JAK-STAT_signaling_pathway" title="JAK-STAT signaling pathway">JAK-STAT</a></li> <li><a href="/wiki/Akt/PKB_signaling_pathway" title="Akt/PKB signaling pathway">Akt/PKB</a></li> <li><a href="/wiki/Apoptosis" title="Apoptosis">Fas apoptosis</a></li> <li><a href="/wiki/Hippo_signaling_pathway" title="Hippo signaling pathway">Hippo</a></li> <li><a href="/wiki/PI3K/AKT/mTOR_pathway" title="PI3K/AKT/mTOR pathway">PI3K/AKT/mTOR pathway</a></li> <li><a href="/wiki/Integrin#Signal_transduction" title="Integrin">Integrin receptors</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Agents</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">Receptor ligands</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hormone" title="Hormone">Hormones</a></li> <li><a href="/wiki/Neurotransmitter" title="Neurotransmitter">Neurotransmitters</a>/<a href="/wiki/Neuropeptide" title="Neuropeptide">Neuropeptides</a>/<a href="/wiki/Neurohormone" title="Neurohormone">Neurohormones</a></li> <li><a href="/wiki/Cytokine" title="Cytokine">Cytokines</a></li> <li><a href="/wiki/Growth_factor" title="Growth factor">Growth factors</a></li> <li><a href="/wiki/Cell_signaling" title="Cell signaling">Signaling molecules</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">Receptors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">Cell surface</a></li> <li><a href="/wiki/Intracellular_receptor" title="Intracellular receptor">Intracellular</a></li> <li><a href="/wiki/Co-receptor" title="Co-receptor">Co-receptor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Second_messenger_system" title="Second messenger system">Second messenger</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CAMP-dependent_pathway" title="CAMP-dependent pathway">cAMP-dependent pathway</a></li> <li><a href="/wiki/Calcium_signaling" title="Calcium signaling">Ca2+ signaling</a></li> <li><a href="/wiki/Lipid_signaling" title="Lipid signaling">Lipid signaling</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Assistants:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Signal_transducing_adaptor_protein" title="Signal transducing adaptor protein">Signal transducing adaptor protein</a></li> <li><a href="/wiki/Scaffold_protein" title="Scaffold protein">Scaffold protein</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/General_transcription_factor" title="General transcription factor">General</a></li> <li><a href="/wiki/Transcription_preinitiation_complex" title="Transcription preinitiation complex">Transcription preinitiation complex</a></li> <li><a href="/wiki/Transcription_factor_II_D" title="Transcription factor II D">TFIID</a></li> <li><a href="/wiki/Transcription_factor_II_H" title="Transcription factor II H">TFIIH</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">By distance</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Juxtacrine_signalling" title="Juxtacrine signalling">Juxtacrine</a></li> <li><a href="/wiki/Autocrine_signalling" class="mw-redirect" title="Autocrine signalling">Autocrine</a> / <a href="/wiki/Paracrine_signalling" class="mw-redirect" title="Paracrine signalling">Paracrine</a></li> <li><a href="/wiki/Endocrine_system" title="Endocrine system">Endocrine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other concepts</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Intracrine" title="Intracrine">Intracrine action</a></li> <li>Neurocrine signaling <ul><li><a href="/wiki/Synaptic_transmission" class="mw-redirect" title="Synaptic transmission">Synaptic transmission</a></li> <li><a href="/wiki/Chemical_synapse" title="Chemical synapse">Chemical synapse</a></li></ul></li> <li><a href="/wiki/Neuroendocrine_cell" title="Neuroendocrine cell">Neuroendocrine signaling</a></li> <li><a href="/wiki/Exocrine_gland" title="Exocrine gland">Exocrine signalling</a> <ul><li><a href="/wiki/Pheromone" title="Pheromone">Pheromones</a></li></ul></li> <li><a href="/wiki/Mechanotransduction" title="Mechanotransduction">Mechanotransduction</a></li> <li><a href="/wiki/Visual_phototransduction" title="Visual phototransduction">Phototransduction</a></li> <li><a href="/wiki/Ion_channel" title="Ion channel">Ion channel gating</a></li> <li><a href="/wiki/Gap_junction" title="Gap junction">Gap junction</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Signaling_pathway:_notch_signaling_pathway" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Notch_signaling_pathway" title="Template:Notch signaling pathway"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Notch_signaling_pathway" title="Template talk:Notch signaling pathway"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Notch_signaling_pathway" title="Special:EditPage/Template:Notch signaling pathway"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Signaling_pathway:_notch_signaling_pathway" style="font-size:114%;margin:0 4em"><a href="/wiki/Signal_transduction" title="Signal transduction">Signaling pathway</a>: <a class="mw-selflink selflink">notch signaling pathway</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">Receptor</a> on signaling cell</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt>Delta</dt> <dd><a href="/wiki/Delta-like_1" title="Delta-like 1">DLL1</a></dd> <dd><a href="/wiki/DLL3" title="DLL3">DLL3</a></dd> <dd><a href="/wiki/DLL4" title="DLL4">DLL4</a></dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">Ligand</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt>Jagged</dt> <dd><a href="/wiki/JAG1" title="JAG1">JAG1</a></dd> <dd><a href="/wiki/JAG2" title="JAG2">JAG2</a></dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Receptor on receiving cell</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Notch_1" title="Notch 1">Notch 1</a></li> <li><a href="/wiki/Notch_2" title="Notch 2">Notch 2</a></li> <li><a href="/wiki/Notch_3" class="mw-redirect" title="Notch 3">Notch 3</a></li> <li><a href="/wiki/Neurogenic_locus_notch_homolog_protein_4" class="mw-redirect" title="Neurogenic locus notch homolog protein 4">Notch 4</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="The_development_of_phenotype" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Genarch" title="Template:Genarch"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Genarch" title="Template talk:Genarch"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Genarch" title="Special:EditPage/Template:Genarch"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="The_development_of_phenotype" style="font-size:114%;margin:0 4em">The <a href="/wiki/Morphogenesis" title="Morphogenesis">development</a> of <a href="/wiki/Phenotype" title="Phenotype">phenotype</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Key concepts</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Genotype%E2%80%93phenotype_distinction" title="Genotype–phenotype distinction">Genotype–phenotype distinction</a></li> <li><a href="/wiki/Reaction_norm" title="Reaction norm">Reaction norm</a></li> <li><a href="/wiki/Gene%E2%80%93environment_interaction" title="Gene–environment interaction">Gene–environment interaction</a></li> <li><a href="/wiki/Gene%E2%80%93environment_correlation" title="Gene–environment correlation">Gene–environment correlation</a></li> <li><a href="/wiki/Operon" title="Operon">Operon</a></li> <li><a href="/wiki/Heritability" title="Heritability">Heritability</a></li> <li><a href="/wiki/Quantitative_genetics" title="Quantitative genetics">Quantitative genetics</a></li> <li><a href="/wiki/Heterochrony" title="Heterochrony">Heterochrony</a> <ul><li><a href="/wiki/Neoteny" title="Neoteny">Neoteny</a></li></ul></li> <li><a href="/wiki/Heterotopy" title="Heterotopy">Heterotopy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Genetic_architecture" title="Genetic architecture">Genetic architecture</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Canalisation_(genetics)" title="Canalisation (genetics)">Canalisation</a></li> <li><a href="/wiki/Genetic_assimilation" title="Genetic assimilation">Genetic assimilation</a></li> <li><a href="/wiki/Dominance_(genetics)" title="Dominance (genetics)">Dominance</a></li> <li><a href="/wiki/Epistasis" title="Epistasis">Epistasis</a></li> <li><a href="/wiki/Fitness_landscape" title="Fitness landscape">Fitness landscape</a>/<a href="/wiki/Evolutionary_landscape" title="Evolutionary landscape">evolutionary landscape</a></li> <li><a href="/wiki/Pleiotropy" title="Pleiotropy">Pleiotropy</a></li> <li><a href="/wiki/Phenotypic_plasticity" title="Phenotypic plasticity">Plasticity</a></li> <li><a href="/wiki/Polygenic_inheritance" class="mw-redirect" title="Polygenic inheritance">Polygenic inheritance</a></li> <li><a href="/wiki/Transgressive_segregation" title="Transgressive segregation">Transgressive segregation</a></li> <li><a href="/wiki/Sequence_space_(evolution)" title="Sequence space (evolution)">Sequence space</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Non-genetic influences</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epigenetics" title="Epigenetics">Epigenetics</a></li> <li><a href="/wiki/Maternal_effect" title="Maternal effect">Maternal effect</a></li> <li><a href="/wiki/Genomic_imprinting" title="Genomic imprinting">Genomic imprinting</a></li> <li><a href="/wiki/Dual_inheritance_theory" title="Dual inheritance theory">Dual inheritance theory</a></li> <li><a href="/wiki/Polyphenism" title="Polyphenism">Polyphenism</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Developmental architecture</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Developmental_biology" title="Developmental biology">Developmental biology</a></li> <li><a href="/wiki/Morphogenesis" title="Morphogenesis">Morphogenesis</a> <ul><li><a href="/wiki/Eyespot_(mimicry)" title="Eyespot (mimicry)">Eyespot</a></li> <li><a href="/wiki/Pattern_formation" title="Pattern formation">Pattern formation</a></li></ul></li> <li><a href="/wiki/Segmentation_(biology)" title="Segmentation (biology)">Segmentation</a></li> <li><a href="/wiki/Metamerism_(biology)" title="Metamerism (biology)">Metamerism</a></li> <li><a href="/wiki/Modularity_(biology)" title="Modularity (biology)">Modularity</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Evolution of genetic systems</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Evolvability" title="Evolvability">Evolvability</a></li> <li><a href="/wiki/Robustness_(evolution)" title="Robustness (evolution)">Robustness</a></li> <li><a href="/wiki/Neutral_network_(evolution)" title="Neutral network (evolution)">Neutral networks</a></li> <li><a href="/wiki/Evolution_of_sexual_reproduction" title="Evolution of sexual reproduction">Evolution of sexual reproduction</a></li> <li><a href="/wiki/Evolutionary_tinkering" title="Evolutionary tinkering">Tinkering</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Control of development</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Systems</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Regulation_of_gene_expression" title="Regulation of gene expression">Regulation of gene expression</a></li> <li><a href="/wiki/Gene_regulatory_network" title="Gene regulatory network">Gene regulatory network</a></li> <li><a href="/wiki/Evo-devo_gene_toolkit" title="Evo-devo gene toolkit">Evo-devo gene toolkit</a></li> <li><a href="/wiki/Evolutionary_developmental_biology" title="Evolutionary developmental biology">Evolutionary developmental biology</a></li> <li><a href="/wiki/Homeobox" title="Homeobox">Homeobox</a></li> <li><a href="/wiki/Hedgehog_signaling_pathway" title="Hedgehog signaling pathway">Hedgehog signaling pathway</a></li> <li><a class="mw-selflink selflink">Notch signaling pathway</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Elements</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Homeotic_gene" title="Homeotic gene">Homeotic gene</a></li> <li><a href="/wiki/Hox_gene" title="Hox gene">Hox gene</a></li> <li><a href="/wiki/Pax_genes" title="Pax genes">Pax genes</a> <ul><li><a href="/wiki/PAX6" title="PAX6">eyeless gene</a></li></ul></li> <li><a href="/wiki/DLX_gene_family" title="DLX gene family">Distal-less</a></li> <li><a href="/wiki/Engrailed_(gene)" title="Engrailed (gene)">Engrailed</a></li> <li><a href="/wiki/Cis-regulatory_element" title="Cis-regulatory element">cis-regulatory element</a></li> <li><a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">Ligand</a></li> <li><a href="/wiki/Morphogen" title="Morphogen">Morphogen</a></li> <li><a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">Cell surface receptor</a></li> <li><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Influential figures</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C._H._Waddington" title="C. H. Waddington">C. H. Waddington</a></li> <li><a href="/wiki/Richard_Lewontin" title="Richard Lewontin">Richard Lewontin</a></li> <li><a href="/wiki/Fran%C3%A7ois_Jacob" title="François Jacob">François Jacob</a> + <a href="/wiki/Jacques_Monod" title="Jacques Monod">Jacques Monod</a> <ul><li><a href="/wiki/Lac_operon" title="Lac operon">Lac operon</a></li></ul></li> <li><a href="/wiki/Eric_F._Wieschaus" title="Eric F. Wieschaus">Eric F. Wieschaus</a></li> <li><a href="/wiki/Christiane_N%C3%BCsslein-Volhard" title="Christiane Nüsslein-Volhard">Christiane Nüsslein-Volhard</a></li> <li><a href="/wiki/William_McGinnis" title="William McGinnis">William McGinnis</a></li> <li><a href="/wiki/Michael_Levine_(biologist)" title="Michael Levine (biologist)">Mike Levine</a></li> <li><a href="/wiki/Sean_B._Carroll" title="Sean B. Carroll">Sean B. Carroll</a> <ul><li><a href="/wiki/Endless_Forms_Most_Beautiful_(book)" title="Endless Forms Most Beautiful (book)">Endless Forms Most Beautiful</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Debates</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nature_versus_nurture" title="Nature versus nurture">Nature versus nurture</a></li> <li><a href="/wiki/Morphogenetic_field" title="Morphogenetic field">Morphogenetic field</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><a href="/wiki/Index_of_evolutionary_biology_articles" title="Index of evolutionary biology articles">Index of evolutionary biology articles</a></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Notch_signaling_pathway&oldid=1246542080">https://en.wikipedia.org/w/index.php?title=Notch_signaling_pathway&oldid=1246542080</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Category</a>: <ul><li><a href="/wiki/Category:Signal_transduction" title="Category:Signal transduction">Signal transduction</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:All_articles_with_dead_external_links" title="Category:All articles with dead external links">All articles with dead external links</a></li><li><a href="/wiki/Category:Articles_with_dead_external_links_from_April_2020" title="Category:Articles with dead external links from April 2020">Articles with dead external links from April 2020</a></li><li><a href="/wiki/Category:Articles_with_permanently_dead_external_links" title="Category:Articles with permanently dead external links">Articles with permanently dead external links</a></li><li><a href="/wiki/Category:Wikipedia_articles_needing_page_number_citations_from_February_2020" title="Category:Wikipedia articles needing page number citations from February 2020">Wikipedia articles needing page number citations from February 2020</a></li><li><a href="/wiki/Category:CS1_errors:_requires_URL" title="Category:CS1 errors: requires URL">CS1 errors: requires URL</a></li><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_matches_Wikidata" title="Category:Short description matches Wikidata">Short description matches Wikidata</a></li><li><a href="/wiki/Category:All_articles_with_unsourced_statements" title="Category:All articles with unsourced statements">All articles with unsourced statements</a></li><li><a href="/wiki/Category:Articles_with_unsourced_statements_from_May_2007" title="Category:Articles with unsourced statements from May 2007">Articles with unsourced statements from May 2007</a></li><li><a href="/wiki/Category:Articles_with_unsourced_statements_from_June_2007" title="Category:Articles with unsourced statements from June 2007">Articles with unsourced statements from June 2007</a></li><li><a href="/wiki/Category:Articles_with_unsourced_statements_from_August_2016" title="Category:Articles with unsourced statements from August 2016">Articles with unsourced statements from August 2016</a></li><li><a href="/wiki/Category:Articles_containing_potentially_dated_statements_from_2013" title="Category:Articles containing potentially dated statements from 2013">Articles containing potentially dated statements from 2013</a></li><li><a href="/wiki/Category:All_articles_containing_potentially_dated_statements" title="Category:All articles containing potentially dated statements">All articles containing potentially dated statements</a></li><li><a href="/wiki/Category:Webarchive_template_wayback_links" title="Category:Webarchive template wayback links">Webarchive template wayback links</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 19 September 2024, at 15:43 (UTC).</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. By using this site, you agree to the <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use" class="extiw" title="foundation:Special:MyLanguage/Policy:Terms of Use">Terms of Use</a> and <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy" class="extiw" title="foundation:Special:MyLanguage/Policy:Privacy policy">Privacy Policy</a>. Wikipedia® is a registered trademark of the <a rel="nofollow" class="external text" href="https://wikimediafoundation.org/">Wikimedia Foundation, Inc.</a>, a non-profit organization.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Privacy policy</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:About">About Wikipedia</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:General_disclaimer">Disclaimers</a></li> <li id="footer-places-contact"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us">Contact Wikipedia</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Code of Conduct</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Developers</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/en.wikipedia.org">Statistics</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Cookie statement</a></li> <li id="footer-places-mobileview"><a href="//en.m.wikipedia.org/w/index.php?title=Notch_signaling_pathway&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobile view</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-57488d5c7d-s6gq6","wgBackendResponseTime":162,"wgPageParseReport":{"limitreport":{"cputime":"1.488","walltime":"1.704","ppvisitednodes":{"value":8748,"limit":1000000},"postexpandincludesize":{"value":438787,"limit":2097152},"templateargumentsize":{"value":4387,"limit":2097152},"expansiondepth":{"value":19,"limit":100},"expensivefunctioncount":{"value":9,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":606586,"limit":5000000},"entityaccesscount":{"value":0,"limit":400},"timingprofile":["100.00% 1428.369 1 -total"," 72.72% 1038.743 1 Template:Reflist"," 58.65% 837.782 130 Template:Cite_journal"," 6.69% 95.629 6 Template:Navbox"," 6.04% 86.315 1 Template:Cell_signaling"," 5.18% 74.015 1 Template:Short_description"," 4.99% 71.341 5 Template:Fix"," 3.99% 57.020 3 Template:Citation_needed"," 3.24% 46.318 2 Template:Pagetype"," 2.34% 33.401 10 Template:Category_handler"]},"scribunto":{"limitreport-timeusage":{"value":"0.927","limit":"10.000"},"limitreport-memusage":{"value":6207180,"limit":52428800}},"cachereport":{"origin":"mw-web.codfw.main-f69cdc8f6-5cxzh","timestamp":"20241122144552","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"Notch signaling pathway","url":"https:\/\/en.wikipedia.org\/wiki\/Notch_signaling_pathway","sameAs":"http:\/\/www.wikidata.org\/entity\/Q904082","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q904082","author":{"@type":"Organization","name":"Contributors to Wikimedia projects"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2004-10-27T05:40:06Z","dateModified":"2024-09-19T15:43:53Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/0\/04\/Notchccr.svg","headline":"series of molecular signals"}</script> </body> </html>