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<!doctype html> <html><head> <title>KEGG ENZYME: 1.1.1.357</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1746686265"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1746686265"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1746686265" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script>  </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="683"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg2.gif"></a></td><td>   </td><td><a name="enzyme:1.1.1.357"></a><font class="title2">ENZYME: 1.1.1.357</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_enzyme.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/kegg-bin/search_htext" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr2 w1"> <table width="650" class="w2"> <tr><th class="th20 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td20 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">EC 1.1.1.357                Enzyme                                 <br> </span></code></td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td21 defd"><div class="cel"><div class="cel">3alpha-hydroxysteroid 3-dehydrogenase;<br> 3alpha-hydroxysteroid dehydrogenase;<br> AKR1C4 (gene name);<br> AKR1C2 (gene name);<br> hsdA (gene name)<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td20 defd"><div class="cel">Oxidoreductases;<br> Acting on the CH-OH group of donors;<br> With NAD+ or NADP+ as acceptor<br> <button class="btn" onclick="location.href='/brite/ko01000+1.1.1.357';return false;">BRITE hierarchy</button></div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Sysname</span></th> <td class="td21 defd"><div class="cel">3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reaction(IUBMB)</span></th> <td class="td20 defd"><div class="cel">a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:<a href="/entry/R10422">R10422</a> <a href="/entry/R10423">R10423</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reaction(KEGG)</span></th> <td class="td21 defd"><div class="cel"><a href="/entry/R10422">R10422</a> > <a href="/entry/R02476">R02476</a> <a href="/entry/R04330">R04330</a> <a href="/entry/R13216">R13216</a>;<br> <a href="/entry/R10423">R10423</a> > <a href="/entry/R02477">R02477</a> <a href="/entry/R08963">R08963</a> <a href="/entry/R13217">R13217</a><br> <button class="btn" onclick="location.href='/entry/R10422/R02476/R04330/R13216/R10423/R02477/R08963/R13217';return false;">Reaction</button></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Substrate</span></th> <td class="td20 defd"><div class="cel">3alpha-hydroxysteroid [CPD:<a href="/entry/C03072">C03072</a>];<br> NAD+ [CPD:<a href="/entry/C00003">C00003</a>];<br> NADP+ [CPD:<a href="/entry/C00006">C00006</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td21 defd"><div class="cel"><div class="cel">3-oxosteroid [CPD:<a href="/entry/C01876">C01876</a>];<br> NADH [CPD:<a href="/entry/C00004">C00004</a>];<br> NADPH [CPD:<a href="/entry/C00005">C00005</a>];<br> H+ [CPD:<a href="/entry/C00080">C00080</a>]<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td20 defd"><div class="cel">The enzyme acts on multiple 3alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. This entry stands for enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known. [cf. EC <a href="/entry/1.1.1.50">1.1.1.50</a>, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) and EC <a href="/entry/1.1.1.213">1.1.1.213</a>, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)].<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">History</span></th> <td class="td21 defd"><div class="cel">EC 1.1.1.357 created 2013<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec00140+1.1.1.357">ec00140</a>  </span></td><td>Steroid hormone biosynthesis</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec01100+1.1.1.357">ec01100</a>  </span></td><td>Metabolic pathways</td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Orthology</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K00037">K00037</a>  </span></td><td>3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K00089">K00089</a>  </span></td><td>3alpha-hydroxysteroid 3-dehydrogenase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K00212">K00212</a>  </span></td><td>20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K04119">K04119</a>  </span></td><td>aldo-keto reductase family 1 member C3</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K19811">K19811</a>  </span></td><td>3alpha-hydroxysteroid 3-dehydrogenase</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Genes</span></th> <td class="td20 defd"><style>span.g1a{color:#003399}span.g1a:hover{color:#33cc99;cursor:pointer;}div.g1{display:none;}</style><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g11">HSA</span>: </span></td><td id="g11d">1109(AKR1C4) 1645(AKR1C1) 1646(AKR1C2) 340811(AKR1C8) 8644(AKR1C3)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g12">PTR</span>: </span></td><td id="g12d">100607996 100612191(AKR1C2) 100612718(AKR1C3) 100612887 450274(AKR1C4) 746545</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g13">PPS</span>: </span></td><td id="g13d">100971300 100986388(AKR1C3) 100986729 100987632 100987989(AKR1C4) 100988315 103783188</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g14">GGO</span>: </span></td><td id="g14d">101144878(AKR1C3) 101146324 101147265(AKR1C8) 101148343 101152195 115936027</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g15">PON</span>: </span></td><td id="g15d">100171658(AKR1C1) 100174617(AKR1C3) 100189776 100432652 100434557(AKR1C4) 100461633 100462259</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g16">PPYG</span>: </span></td><td id="g16d">129006137 129006867 129006869 129006872 129006873 129006874(AKR1C8) 129006876(AKR1C4)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g17">NLE</span>: </span></td><td id="g17d">100593325 100603603 100604844 100605385 100605934 100606512</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g18">HMH</span>: </span></td><td id="g18d">116457046 116457717 116460197(AKR1C8) 116461800(AKR1C4)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g19">SSYN</span>: </span></td><td id="g19d">129491830 129491831 129491832 129491834 129491837 129491838</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g110">MCC</span>: </span></td><td id="g110d">100430336 711198(AKR1C1) 711360(AKR1C2) 711440 722483 722485 722490(AKR1C4) 722496</td></tr></table><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g111">MCF</span>: </span></td><td id="g111d">101865536(AKR1C1) 102116465 102116844 102117205 102141103 102142023(HSD17B5) 102143072 102144231</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g112">MTHB</span>: </span></td><td id="g112d">126963005 126963006 126963007 126963008 126963009 126963422</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g113">MNI</span>: </span></td><td id="g113d">105490778 105490779 105490780 105490781 105490782 105490783 105494391 112428206</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g114">CSAB</span>: </span></td><td id="g114d">103237807 103237808 103237812 103237813 103237814 103237816</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g115">CATY</span>: </span></td><td id="g115d">105587685 105587688 105587690 105597444 105597446 105597447 105597481</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g116">PANU</span>: </span></td><td id="g116d">100997485 101022585 101022938 101023297 101024707</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g117">TGE</span>: </span></td><td id="g117d">112631307 112631308 112631309 112631314 112631750</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g118">MLEU</span>: </span></td><td id="g118d">105532487 105532488 105532490 105532496 105535734 105535762 105535763</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g119">RRO</span>: </span></td><td id="g119d">104674747 104674748 104678924 104678925</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g120">RBB</span>: </span></td><td id="g120d">108521035 108521036 108532990 108532991 108532992</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g121">TFN</span>: </span></td><td id="g121d">117082052 117082118 117082119 117082359 117083437 117083548 117083560 117087703 117087714</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g122">PTEH</span>: </span></td><td id="g122d">111528130 111528985 113224919</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g123">CANG</span>: </span></td><td id="g123d">105521699 105521700 105521701 105521702 105521704 105521705</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g124">CJC</span>: </span></td><td id="g124d">100404656(AKR1C1) 100405255 100405615(AKR1C4) 100406962 100409025 100409384</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g125">SBQ</span>: </span></td><td id="g125d">101041594 101041915 101042225 101042532 101049957</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g126">CIMI</span>: </span></td><td id="g126d">108285104 108285106 108292323 108292324(AKR1C4) 108292325 108292357</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g127">ANAN</span>: </span></td><td id="g127d">105710839 105710841 105710885 105710886 105710887 105710891</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g128">CSYR</span>: </span></td><td id="g128d">103261879 103261880 103261882 103261883 103263298 103263300</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g129">MMUR</span>: </span></td><td id="g129d">105858219 105858220 105858221 105858224</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g130">LCAT</span>: </span></td><td id="g130d">123623042 123623043 123623044 123623047</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g131">PCOQ</span>: </span></td><td id="g131d">105826891 105826910 105826913</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g132">OGA</span>: </span></td><td id="g132d">100940488 100942491 100967071</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g133">MMU</span>: </span></td><td id="g133d">77337(Akr1c21)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g134">MCAL</span>: </span></td><td id="g134d">110308148 110308710</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g135">MPAH</span>: </span></td><td id="g135d">110315750 110333790 110333839 110333848</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g136">RNO</span>: </span></td><td id="g136d">291283(Akr1c2) 307092(Akr1c1) 361267(Akr1c15)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g137">MCOC</span>: </span></td><td id="g137d">116081731 116081947</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g138">ANU</span>: </span></td><td id="g138d">117713832 117713854</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g139">ASYL</span>: </span></td><td id="g139d">127664685 127664762</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g140">MUN</span>: </span></td><td id="g140d">110539888 110540933 110542801 110560700 132649305</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g141">CGE</span>: </span></td><td id="g141d">100768090 100768376 100770100 100770388</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g142">MAUA</span>: </span></td><td id="g142d">101839651 101841267 101843587</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g143">PROB</span>: </span></td><td id="g143d">127229800 127229804</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g144">PLEU</span>: </span></td><td id="g144d">114707814 114708002 114708030 114708096</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g145">MORG</span>: </span></td><td id="g145d">121432600 121432606 121432658 121432668</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g146">MFOT</span>: </span></td><td id="g146d">126501679 126501680 126501681 126501693 126506800</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g147">AAMP</span>: </span></td><td id="g147d">119816160 119816243 119817583 119826549</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g148">NGI</span>: </span></td><td id="g148d">103725884 103725890 103725892 103725895 103746652</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g149">HGL</span>: </span></td><td id="g149d">101702106 101716553</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g150">CPOC</span>: </span></td><td id="g150d">100722094 100724342 100724620 100727454</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g151">CCAN</span>: </span></td><td id="g151d">109678869 109680334 109680485 109680990</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g152">DSP</span>: </span></td><td id="g152d">122113031</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g153">PLOP</span>: </span></td><td id="g153d">125366785</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g154">NCAR</span>: </span></td><td id="g154d">124961142 124961655</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g155">MMMA</span>: </span></td><td id="g155d">107134068 107150202 107150203</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g156">ITI</span>: </span></td><td id="g156d">101954502 101978171</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g157">OCU</span>: </span></td><td id="g157d">100348607(PGER1) 100352716 108176284</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g158">OPI</span>: </span></td><td id="g158d">101524567 101525116 101525279 101525842 101526245 101526664 101526901 101527313 101527569 101527977 118759111</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g159">TUP</span>: </span></td><td id="g159d">102478063 102478495 102491222 102491650</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g160">GVR</span>: </span></td><td id="g160d">103581518 103602898 103610229 103610426</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g161">CFA</span>: </span></td><td id="g161d">497070(AKR1C3)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g162">CLUD</span>: </span></td><td id="g162d">112658979</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g163">VVP</span>: </span></td><td id="g163d">112933725</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g164">VLG</span>: </span></td><td id="g164d">121496638</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g165">NPO</span>: </span></td><td id="g165d">129514265</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g166">AML</span>: </span></td><td id="g166d">100483758</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g167">UMR</span>: </span></td><td id="g167d">103676234</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g168">UAH</span>: </span></td><td id="g168d">113241124</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g169">UAR</span>: </span></td><td id="g169d">123802294(AKR1C8)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g170">ELK</span>: </span></td><td id="g170d">111158636</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g171">LLV</span>: </span></td><td id="g171d">125107753</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g172">MPUF</span>: </span></td><td id="g172d">101678776</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g173">MNP</span>: </span></td><td id="g173d">132020017</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g174">MLK</span>: </span></td><td id="g174d">131838054</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g175">NVS</span>: </span></td><td id="g175d">122891768(AKR1C4)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g176">ORO</span>: </span></td><td id="g176d">101377633 101379669</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g177">EJU</span>: </span></td><td id="g177d">114217720</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g178">ZCA</span>: </span></td><td id="g178d">113921662</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g179">MLX</span>: </span></td><td id="g179d">118021623 118021905</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g180">LWW</span>: </span></td><td id="g180d">102748666 102748964</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g181">FCA</span>: </span></td><td id="g181d">100510801(AKR1C3)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g182">PYU</span>: </span></td><td id="g182d">121014878</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g183">PCOO</span>: </span></td><td id="g183d">112867557</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g184">PBG</span>: </span></td><td id="g184d">122473163</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g185">PVIV</span>: </span></td><td id="g185d">125169528</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g186">LRUF</span>: </span></td><td id="g186d">124502362</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g187">LGF</span>: </span></td><td id="g187d">123591606</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g188">AJU</span>: </span></td><td id="g188d">106988139</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g189">PTG</span>: </span></td><td id="g189d">102963188</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g190">PPAD</span>: </span></td><td id="g190d">109273789</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g191">PUC</span>: </span></td><td id="g191d">125918575</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g192">PLEZ</span>: </span></td><td id="g192d">122223817</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g193">HHV</span>: </span></td><td id="g193d">120237198</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g194">BTA</span>: </span></td><td id="g194d">100139386(20ALPHA-HSD) 112441538 112449293 132342088 132342107 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g195">BOM</span>: </span></td><td id="g195d">102269337 102271453 102271733 102272308 102272594 102272882 102273443</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g196">BIU</span>: </span></td><td id="g196d">109567627 109568074 109568076 109568077 109568079 109568080 109568087</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g197">BBUB</span>: </span></td><td id="g197d">102389138 102395293 102395635 102396460 102396772 102399119 102400645 102404780 102415234</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g198">BBIS</span>: </span></td><td id="g198d">104985980 104985985 104985990 104985991 104985992 104985994 104985995 104985998 104985999 104986133</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g199">CHX</span>: </span></td><td id="g199d">102176340 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1100">OAS</span>: </span></td><td id="g1100d">101107119 101107541 101109111 101109377 101110434 101110693 105614315 106990122 114108656</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1101">BTAX</span>: </span></td><td id="g1101d">128058197 128058202 128058203 128058208 128058211 128058212 128058213 128058216</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1102">CSUM</span>: </span></td><td id="g1102d">138091116 138091651 138091745 138091796 138091808 138091833 138091836 138091865 138091869</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1103">ODA</span>: </span></td><td id="g1103d">120860627 120868601 120869467 120869469 120869471</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1104">CCAD</span>: </span></td><td id="g1104d">122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512 122448583</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1105">MREE</span>: </span></td><td id="g1105d">136157847 136157852 136157854 136157856 136157857 136159311 136159313 136159314 136159316 136159318</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1106">OVR</span>: </span></td><td id="g1106d">110127514 110142553 110142554 110142557 110142558 110142563 139029592</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1107">MBEZ</span>: </span></td><td id="g1107d">129547517 129555459 129559457 129559483 129559564 129559569 129559578 129559602 129559618 129559630 129559646</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1108">SSC</span>: </span></td><td id="g1108d">654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1109">CFR</span>: </span></td><td id="g1109d">102511678 116656624 116661570</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1110">CBAI</span>: </span></td><td id="g1110d">105074137 105074417 105074427 105074728</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1111">CDK</span>: </span></td><td id="g1111d">105104488 105104489 105105880</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1112">VPC</span>: </span></td><td id="g1112d">102531609 102541232 102541486</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1113">BACU</span>: </span></td><td id="g1113d">103002145 103003050</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1114">BMUS</span>: </span></td><td id="g1114d">118891073 118891271</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1115">LVE</span>: </span></td><td id="g1115d">103069218</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1116">OOR</span>: </span></td><td id="g1116d">101273575 101281536</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1117">LALB</span>: </span></td><td id="g1117d">132525824 132525832</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1118">DLE</span>: </span></td><td id="g1118d">111170128 111170129</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1119">PCAD</span>: </span></td><td id="g1119d">102978533</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1120">PSIU</span>: </span></td><td id="g1120d">116748968 116749098</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1121">NASI</span>: </span></td><td id="g1121d">112407550 112407551</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1122">ECB</span>: </span></td><td id="g1122d">100057212 100057251 100070491 100070501 100070509 100070570 100070616 111771771 111771772</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1123">EPZ</span>: </span></td><td id="g1123d">103540777 103540778 103541472 103541473 103542048 139080563</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1124">EAI</span>: </span></td><td id="g1124d">106824650 106827241 106827243 106827244 106827468 106846832 106846833 106846834 123281999</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1125">MYB</span>: </span></td><td id="g1125d">102254990 102255491</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1126">MYD</span>: </span></td><td id="g1126d">102751586 102763642</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1127">MMYO</span>: </span></td><td id="g1127d">118672630 118672665</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1128">MLF</span>: </span></td><td id="g1128d">102421358 102428982</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1129">MDT</span>: </span></td><td id="g1129d">132215226 132215243</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1130">MYUM</span>: </span></td><td id="g1130d">138992421 138992439</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1131">PKL</span>: </span></td><td id="g1131d">118702292 118702295</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1132">EFUS</span>: </span></td><td id="g1132d">103300835 103300840</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1133">MNA</span>: </span></td><td id="g1133d">107542430 107542432</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1134">DRO</span>: </span></td><td id="g1134d">112321159 112323007</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1135">SHON</span>: </span></td><td id="g1135d">118977133</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1136">AJM</span>: </span></td><td id="g1136d">119057712</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1137">PDIC</span>: </span></td><td id="g1137d">114492418</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1138">PHAS</span>: </span></td><td id="g1138d">123824859 123831227(AKR1C8)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1139">MMF</span>: </span></td><td id="g1139d">118632067 118632135</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1140">PPAM</span>: </span></td><td id="g1140d">129084610 129084627</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1141">HAI</span>: </span></td><td id="g1141d">109378613</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1142">PALE</span>: </span></td><td id="g1142d">102889546</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1143">PGIG</span>: </span></td><td id="g1143d">120608988</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1144">PVP</span>: </span></td><td id="g1144d">105299187</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1145">MJV</span>: </span></td><td id="g1145d">108384939 108393830 108407235 108407237 108407238</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1146">TOD</span>: </span></td><td id="g1146d">119244650 119245260</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1147">SARA</span>: </span></td><td id="g1147d">101543981 101545704 101551007 101551999 101555320 101555749</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1148">SFUM</span>: </span></td><td id="g1148d">130024001 130024071 130024072 130024073 130024074</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1149">SETR</span>: </span></td><td id="g1149d">126013285</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1150">LAV</span>: </span></td><td id="g1150d">100659630 100659914 100660861</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1151">TMU</span>: </span></td><td id="g1151d">101342771 101360332</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1152">ETF</span>: </span></td><td id="g1152d">101653259 101653576</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1153">DNM</span>: </span></td><td id="g1153d">101426998 101428157 101429786 101433437 101433871 101435315</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1154">GAS</span>: </span></td><td id="g1154d">123247018 123248678</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1155">AFZ</span>: </span></td><td id="g1155d">127564339</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1156">TVP</span>: </span></td><td id="g1156d">118850247 118850334</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1157">PBRV</span>: </span></td><td id="g1157d">138165825 138165836 138165837 138165895</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1158">OAA</span>: </span></td><td id="g1158d">100085065 100085983</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1159">PSS</span>: </span></td><td id="g1159d">102446010 102446253 102446483</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1160">CMY</span>: </span></td><td id="g1160d">102946053 119563672</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1161">CCAY</span>: </span></td><td id="g1161d">125625831</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1162">DCC</span>: </span></td><td id="g1162d">119843778 119849865</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1163">CPIC</span>: </span></td><td id="g1163d">101940001 101940260 101940524</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1164">TST</span>: </span></td><td id="g1164d">117882842</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1165">CABI</span>: </span></td><td id="g1165d">116815619</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1166">MRV</span>: </span></td><td id="g1166d">120395343 120395491 120395494 120395542</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1167">PVT</span>: </span></td><td id="g1167d">110070400 110071420 110088827</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1168">PMUA</span>: </span></td><td id="g1168d">114590236 114604979 114604980 114604981 114605230 114605592</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1169">PRAF</span>: </span></td><td id="g1169d">128421905 128421906 128421907 128421908 128421909 128422029</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1170">ZVI</span>: </span></td><td id="g1170d">118090693 118090694 118090915</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1171">GJA</span>: </span></td><td id="g1171d">107108026</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1172">EMC</span>: </span></td><td id="g1172d">129335705</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1173">XLA</span>: </span></td><td id="g1173d">100049750(XB5895996.L) 108712557(akr1c4.S) 443571(akr1c3.L)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1174">XTR</span>: </span></td><td id="g1174d">100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 496490(akr1c4) 734139 779627(akr1c3)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1175">NPR</span>: </span></td><td id="g1175d">108789947 108789949 108799287 108799288 108799289 108799290 108799291 108799292</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1176">RTEM</span>: </span></td><td id="g1176d">120921832 120932840 120932842</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1177">BBUF</span>: </span></td><td id="g1177d">121003666</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1178">BGAR</span>: </span></td><td id="g1178d">122926607</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1179">PWL</span>: </span></td><td id="g1179d">138287510 138287511 138287512 138287514 138288486</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1180">MUO</span>: </span></td><td id="g1180d">115477556</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1181">GSH</span>: </span></td><td id="g1181d">117364122</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1182">CPLA</span>: </span></td><td id="g1182d">122559456</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1183">HOC</span>: </span></td><td id="g1183d">132825023</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1184">BBEL</span>: </span></td><td id="g1184d">109473367</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1185">PFLL</span>: </span></td><td id="g1185d">139134268</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1186">PPYR</span>: </span></td><td id="g1186d">116168970</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1187">DMK</span>: </span></td><td id="g1187d">116918341</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1188">PMEO</span>: </span></td><td id="g1188d">129593135</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1189">PVUL</span>: </span></td><td id="g1189d">126823863 130010387</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1190">HASI</span>: </span></td><td id="g1190d">137266197</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1191">PMAX</span>: </span></td><td id="g1191d">117329343 117329344 117331065</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1192">AIRR</span>: </span></td><td id="g1192d">138327949</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1193">MCAF</span>: </span></td><td id="g1193d">127727738</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1194">MMER</span>: </span></td><td id="g1194d">123536211</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1195">CTT</span>: </span></td><td id="g1195d">CtCNB1_1322</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1196">CTES</span>: </span></td><td id="g1196d">O987_07590</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1197">CRJ</span>: </span></td><td id="g1197d">QMY55_06895</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1198">SMIO</span>: </span></td><td id="g1198d">CATMQ487_31860</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1199">NTC</span>: </span></td><td id="g1199d">KHQ06_28825</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1200">NHU</span>: </span></td><td id="g1200d">H0264_27905</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1201">NYA</span>: </span></td><td id="g1201d">LTV02_06370</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1202">NYU</span>: </span></td><td id="g1202d">D7D52_11570</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1203">AACD</span>: </span></td><td id="g1203d">LWP59_16945</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1204">ATHM</span>: </span></td><td id="g1204d">L1857_34415</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1205">AMOG</span>: </span></td><td id="g1205d">QRX60_45535</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g1206">ACYN</span>: </span></td><td id="g1206d">ORV05_17285</td></tr></table></div><a href="javascript:void(0)" onclick="javascript:toggleField(this,"g1","show all","hide")"> » show all</a><br> <script>for(var i=1;i<=206;i++){if(document.getElementById('g1'+i)){document.getElementById('g1'+i).onclick = function(e){geg1(this,e);};}}function geg1(bobj){var id = bobj.id;var ab = document.getElementById(id).innerText;var dt = document.getElementById(id+'d');var st = dt.innerText.replace(/$[^$]+\)/g,'').replace(/ /g,'+');var gt = '/entry/'+ab+'+'+st;location.href = gt;}</script><input type="hidden" name="query" form="form1" value="HSA PTR PPS GGO PON PPYG NLE HMH SSYN MCC MCF MTHB MNI CSAB CATY PANU TGE MLEU RRO RBB TFN PTEH CANG CJC SBQ CIMI ANAN CSYR MMUR LCAT PCOQ OGA MMU MCAL MPAH RNO MCOC ANU ASYL MUN CGE MAUA PROB PLEU MORG MFOT AAMP NGI HGL CPOC CCAN DSP PLOP NCAR MMMA ITI OCU OPI TUP GVR CFA CLUD VVP VLG NPO AML UMR UAH UAR ELK LLV MPUF MNP MLK NVS ORO EJU ZCA MLX LWW FCA PYU PCOO PBG PVIV LRUF LGF AJU PTG PPAD PUC PLEZ HHV BTA BOM BIU BBUB BBIS CHX OAS BTAX CSUM ODA CCAD MREE OVR MBEZ SSC CFR CBAI CDK VPC BACU BMUS LVE OOR LALB DLE PCAD PSIU NASI ECB EPZ EAI MYB MYD MMYO MLF MDT MYUM PKL EFUS MNA DRO SHON AJM PDIC PHAS MMF PPAM HAI PALE PGIG PVP MJV TOD SARA SFUM SETR LAV TMU ETF DNM GAS AFZ TVP PBRV OAA PSS CMY CCAY DCC CPIC TST CABI MRV PVT PMUA PRAF ZVI GJA EMC XLA XTR NPR RTEM BBUF BGAR PWL MUO GSH CPLA HOC BBEL PFLL PPYR DMK PMEO PVUL HASI PMAX AIRR MCAF MMER CTT CTES CRJ SMIO NTC NHU NYA NYU AACD ATHM AMOG ACYN"><input type="hidden" name="htext" form="form1" value="br08601.keg"><input type="hidden" name="option" form="form1" value="-a"><button class="btn" onclick="javascript:go_taxonomy(document.form1,{"action":"/kegg-bin/search_htext"});return false;">Taxonomy</button></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td21 defd"><div class="cel">1  [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/8172617">8172617</a>]</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td20 repd"><div class="cel">Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td21 repd"><div class="cel">Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td20 repd"><div class="cel">Biochem J 299 ( Pt 2):545-52 (1994)<br>DOI:<a href="https://doi.org/10.1042/bj2990545">10.1042/bj2990545</a></div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Sequence</span></th> <td class="td21 repd"><div class="cel">[hsa:<a href="/entry/hsa:1645">1645</a> <a href="/entry/hsa:1109">1109</a>]</div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">2  [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/7650035">7650035</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td21 repd"><div class="cel">Khanna M, Qin KN, Wang RW, Cheng KC</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td20 repd"><div class="cel">Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td21 repd"><div class="cel">J Biol Chem 270:20162-8 (1995)<br>DOI:<a href="https://doi.org/10.1074/jbc.270.34.20162">10.1074/jbc.270.34.20162</a></div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Sequence</span></th> <td class="td20 repd"><div class="cel">[hsa:<a href="/entry/hsa:8644">8644</a>]</div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td21 defd"><div class="cel">3  [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/8944761">8944761</a>]</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td20 repd"><div class="cel">Oppermann UC, Maser E</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td21 repd"><div class="cel">Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the gram-negative bacterium Comamonas testosteroni.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td20 repd"><div class="cel">Eur J Biochem 241:744-9 (1996)<br>DOI:<a href="https://doi.org/10.1111/j.1432-1033.1996.00744.x">10.1111/j.1432-1033.1996.00744.x</a></div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Sequence</span></th> <td class="td21 repd"><div class="cel">[ctt:<a href="/entry/ctt:CtCNB1_1322">CtCNB1_1322</a>]</div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">4  [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/9812981">9812981</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td21 repd"><div class="cel">Mobus E, Maser E</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td20 repd"><div class="cel">Molecular cloning, overexpression, and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. A novel member of the short-chain dehydrogenase/reductase superfamily.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td21 repd"><div class="cel">J Biol Chem 273:30888-96 (1998)<br>DOI:<a href="https://doi.org/10.1074/jbc.273.47.30888">10.1074/jbc.273.47.30888</a></div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Sequence</span></th> <td class="td20 repd"><div class="cel">[ctt:<a href="/entry/ctt:CtCNB1_1322">CtCNB1_1322</a>]</div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td21 defd"><div class="cel">5  [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/11514561">11514561</a>]</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Authors</span></th> <td class="td20 repd"><div class="cel">Nahoum V, Gangloff A, Legrand P, Zhu DW, Cantin L, Zhorov BS, Luu-The V, Labrie F, Breton R, Lin SX</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Title</span></th> <td class="td21 repd"><div class="cel">Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap">  Journal</span></th> <td class="td20 repd"><div class="cel">J Biol Chem 276:42091-8 (2001)<br>DOI:<a href="https://doi.org/10.1074/jbc.M105610200">10.1074/jbc.M105610200</a></div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap">  Sequence</span></th> <td class="td21 repd"><div class="cel">[hsa:<a href="/entry/hsa:1646">1646</a>]</div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExplorEnz - The Enzyme Database: </span></td><td><a href="https://www.enzyme-database.org/query.php?ec=1.1.1.357">1.1.1.357</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">IUBMB Enzyme Nomenclature: </span></td><td><a href="https://iubmb.qmul.ac.uk/enzyme/EC1/1/1/357.html">1.1.1.357</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExPASy - ENZYME nomenclature database: </span></td><td><a href="https://enzyme.expasy.org/EC/1.1.1.357">1.1.1.357</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">BRENDA, the Enzyme Database: </span></td><td><a href="https://www.brenda-enzymes.info/enzyme.php?ecno=1.1.1.357">1.1.1.357</a></td></tr></table></td></tr> <tr><th class="th21 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td21 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?enzyme+1.1.1.357';return false;">All DBs</button></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>