The Prognostic Value of DNA Ploidy Determination in Endometr

<!DOCTYPE html> <html lang="es"> <head> <title>The Prognostic Value of DNA Ploidy Determination in Endometr | 467</title> <meta name="keywords" content="Massimo Origoni, Patrizia De Marzi, Giada Almirante, Jessica Ottolina, Luigi Frigerio, Marco Carnelli, Chiara Gelardi and Massimo Candiani, "/> <meta name="description" content="Aneuploidy, defined as an abnormal quantity of DNA in cells nuclei, is the most frequently observed genetic abnormality in cancer cells. Alterations in cel..467"/> <meta name="citation_publisher" content="Ciencia y tecnolog铆a" /> <meta name="citation_journal_title" content="Revista de oncología clínica y experimental"> <meta name="citation_title" content="The Prognostic Value of DNA Ploidy Determination in Endometrial Cancer"> <meta name="citation_author" content="Massimo Origoni" /> <meta name="citation_author" content="Patrizia De Marzi" /> <meta name="citation_author" content="Giada Almirante" /> <meta name="citation_author" content="Jessica Ottolina" /> <meta name="citation_author" content="Luigi Frigerio" /> <meta name="citation_author" content="Marco Carnelli" /> <meta name="citation_author" content="Chiara Gelardi" /> <meta name="citation_author" content="Massimo C" /> <meta name="citation_author" content="iani" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="2"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="Aneuploidy, defined as an abnormal quantity of DNA in cells nuclei, is the most frequently observed genetic abnormality in cancer cells. Alterations in cell cycle control and chromosomal missegregation very often result in the accumulation of excess genetic material. These genetic reassortments simultaneously imbalance lots of structural and regulatory proteins. This chromosomal instability may be associated with mutations in tumor suppressor genes or loss of function of mismatch repair genes. These are common pathways of cancerogenesis in endometrial cancer. Endometrial cancer represents the most common female genital tract malignancy and is generally associated with favourable outcomes for affected patients. Despite this, recurrence rates and diseaserelated deaths are consistently reported in published series, also in so-defined low-risk groups of patients. Hence, is reasonable to believe that traditional prognostic factors–surgical stage, histologic type, tumor grading, myometrial deep of invasion, involvement of vascular spaces–do not definitely respond to the clinical needs of a comprehensive management. The determination of DNA ploidy in endometrial cancer has been widely investigated in the last decades and clear evidence is available of its direct correlation with prognosis. Despite this, poor acceptance and skepticism are common believes in the scientific community. Aim of the paper has been the attempt to underline, upon scientific strength, the importance and clinical potential usefulness of this determination in gynecological oncological practice."> <meta name="citation_abstract_html_url" content="https://spanish.scitechnol.com/abstract/the-prognostic-value-of-dna-ploidy-determination-in-endometrial-cancer-467.html"> <meta itemprop="name" content="Ciencia y tecnolog铆a" /> <meta name="format-detection" content="telephone=no"> <meta http-equiv="Content-Language" content="es"> <meta name="google-site-verification" content="fht0Sbphb4JsUdVMASeyamGbjQ-E68ZABbBD_5ogQXY" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link rel="canonical" href="https://spanish.scitechnol.com/abstract/the-prognostic-value-of-dna-ploidy-determination-in-endometrial-cancer-467.html"> 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Alterations in cell cycle control and chromosomal missegregation very often result in the accumulation of excess genetic material. These genetic reassortments simultaneously imbalance lots of structural and regulatory proteins. This chromosomal instability may be associated with mutations in tumor suppressor genes or loss of function of mismatch repair genes. These are common pathways of cancerogenesis in endometrial cancer. Endometrial cancer represents the most common female genital tract malignancy and is generally associated with favourable outcomes for affected patients. Despite this, recurrence rates and diseaserelated deaths are consistently reported in published series, also in so-defined low-risk groups of patients. Hence, is reasonable to believe that traditional prognostic factors–surgical stage, histologic type, tumor grading, myometrial deep of invasion, involvement of vascular spaces–do not definitely respond to the clinical needs of a comprehensive management. The determination of DNA ploidy in endometrial cancer has been widely investigated in the last decades and clear evidence is available of its direct correlation with prognosis. Despite this, poor acceptance and skepticism are common believes in the scientific community. Aim of the paper has been the attempt to underline, upon scientific strength, the importance and clinical potential usefulness of this determination in gynecological oncological practice.</p></p> <div class="alert alert-info text-left"><b>Descargo de responsabilidad:</b> este resumen se tradujo utilizando herramientas de inteligencia artificial y a煤n no ha sido revisado ni verificado.</div> </div> </div>  <div class="col-xs-12 col-md-3"> <div class="divider-v4 divider-v4-left-double bg-color-white padding-10 margin-b-10"> <h2 class="divider-v4-title">Explorar SciTechnol</h2> <div> <ul class="list-unstyled angle-right"> <li class="color-base"><a href="https://spanish.scitechnol.com/author-guidelines.html" title="haga clic aqu铆"> Pautas para el autor</a></li> <li class="color-base"><a href="https://spanish.scitechnol.com/reviewer-guidelines.html" title="haga clic aqu铆"> Directrices para el revisor</a></li> <li class="color-base"><a 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The Prognostic Value of DNA Ploidy Determination in Endometr | 467