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The Prognostic Value of DNA Ploidy Determination in Endometr | 467
<!DOCTYPE html> <html lang="te"> <head> <title>The Prognostic Value of DNA Ploidy Determination in Endometr | 467</title> <meta name="keywords" content="Massimo Origoni, Patrizia De Marzi, Giada Almirante, Jessica Ottolina, Luigi Frigerio, Marco Carnelli, Chiara Gelardi and Massimo Candiani, "/> <meta name="description" content="Aneuploidy, defined as an abnormal quantity of DNA in cells nuclei, is the most frequently observed genetic abnormality in cancer cells. Alterations in cel..467"/> <meta name="citation_publisher" content="సైటెక్నాల్" /> <meta name="citation_journal_title" content="జర్నల్ ఆఫ్ క్లినికల్ & ఎక్స్‌పెరిమెంటల్ ఆంకాలజీ"> <meta name="citation_title" content="The Prognostic Value of DNA Ploidy Determination in Endometrial Cancer"> <meta name="citation_author" content="Massimo Origoni" /> <meta name="citation_author" content="Patrizia De Marzi" /> <meta name="citation_author" content="Giada Almirante" /> <meta name="citation_author" content="Jessica Ottolina" /> <meta name="citation_author" content="Luigi Frigerio" /> <meta name="citation_author" content="Marco Carnelli" /> <meta name="citation_author" content="Chiara Gelardi" /> <meta name="citation_author" content="Massimo C" /> <meta name="citation_author" content="iani" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="2"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="Aneuploidy, defined as an abnormal quantity of DNA in cells nuclei, is the most frequently observed genetic abnormality in cancer cells. Alterations in cell cycle control and chromosomal missegregation very often result in the accumulation of excess genetic material. These genetic reassortments simultaneously imbalance lots of structural and regulatory proteins. This chromosomal instability may be associated with mutations in tumor suppressor genes or loss of function of mismatch repair genes. These are common pathways of cancerogenesis in endometrial cancer. Endometrial cancer represents the most common female genital tract malignancy and is generally associated with favourable outcomes for affected patients. Despite this, recurrence rates and diseaserelated deaths are consistently reported in published series, also in so-defined low-risk groups of patients. Hence, is reasonable to believe that traditional prognostic factors–surgical stage, histologic type, tumor grading, myometrial deep of invasion, involvement of vascular spaces–do not definitely respond to the clinical needs of a comprehensive management. The determination of DNA ploidy in endometrial cancer has been widely investigated in the last decades and clear evidence is available of its direct correlation with prognosis. Despite this, poor acceptance and skepticism are common believes in the scientific community. Aim of the paper has been the attempt to underline, upon scientific strength, the importance and clinical potential usefulness of this determination in gynecological oncological practice."> <meta name="citation_abstract_html_url" content="https://telugu.scitechnol.com/abstract/the-prognostic-value-of-dna-ploidy-determination-in-endometrial-cancer-467.html"> <meta itemprop="name" content="సైటెక్నాల్" /> <meta name="format-detection" content="telephone=no"> <meta http-equiv="Content-Language" content="te"> <meta name="google-site-verification" content="fht0Sbphb4JsUdVMASeyamGbjQ-E68ZABbBD_5ogQXY" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link rel="canonical" href="https://telugu.scitechnol.com/abstract/the-prognostic-value-of-dna-ploidy-determination-in-endometrial-cancer-467.html"> <link 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Alterations in cell cycle control and chromosomal missegregation very often result in the accumulation of excess genetic material. These genetic reassortments simultaneously imbalance lots of structural and regulatory proteins. This chromosomal instability may be associated with mutations in tumor suppressor genes or loss of function of mismatch repair genes. These are common pathways of cancerogenesis in endometrial cancer. Endometrial cancer represents the most common female genital tract malignancy and is generally associated with favourable outcomes for affected patients. Despite this, recurrence rates and diseaserelated deaths are consistently reported in published series, also in so-defined low-risk groups of patients. Hence, is reasonable to believe that traditional prognostic factors–surgical stage, histologic type, tumor grading, myometrial deep of invasion, involvement of vascular spaces–do not definitely respond to the clinical needs of a comprehensive management. The determination of DNA ploidy in endometrial cancer has been widely investigated in the last decades and clear evidence is available of its direct correlation with prognosis. Despite this, poor acceptance and skepticism are common believes in the scientific community. Aim of the paper has been the attempt to underline, upon scientific strength, the importance and clinical potential usefulness of this determination in gynecological oncological practice.</p></p> <div class="alert alert-info text-left"><b>నిరాకరణ:</b> ఈ సారాంశం ఆర్టిఫిషియల్ ఇంటెలిజెన్స్ టూల్స్ ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా నిర్ధారించబడలేదు</div> </div> </div> <!-- sidebar --> <div class="col-xs-12 col-md-3"> <div class="divider-v4 divider-v4-left-double bg-color-white padding-10 margin-b-10"> <h2 class="divider-v4-title">SciTechnolని అన్వేషించండి</h2> <div> <ul class="list-unstyled angle-right"> <li class="color-base"><a href="https://telugu.scitechnol.com/author-guidelines.html" title="ఇక్కడ నొక్కండి"> రచయిత మార్గదర్శకాలు</a></li> <li class="color-base"><a href="https://telugu.scitechnol.com/reviewer-guidelines.html" title="ఇక్కడ నొక్కండి"> సమీక్షకుల మార్గదర్శకాలు</a></li> <li class="color-base"><a 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