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ul.cart a.cart-contents, #navigation .cart-contents #navigation ul.rss, #navigation ul.nav-search, #navigation ul.nav-search a { font: 14px/1.2em Helvetica, Arial, sans-serif;color:#666666; } #navigation ul.rss li a:before, #navigation ul.nav-search a.search-contents:before { color:#666666;} #navigation ul.nav li ul, #navigation ul.cart > li > ul > div { border: 0px solid #dbdbdb; } #navigation ul.nav > li:hover > ul { left: 0; } #navigation ul.nav > li { border-right: 0px solid #dbdbdb; }#navigation ul.nav > li:hover > ul { left: 0; } #navigation { box-shadow: none; -moz-box-shadow: none; -webkit-box-shadow: none; }#navigation ul li:first-child, #navigation ul li:first-child a { border-radius:0px 0 0 0px; -moz-border-radius:0px 0 0 0px; -webkit-border-radius:0px 0 0 0px; } #navigation {border-top:0px solid #dbdbdb;border-bottom:0px solid #dbdbdb;border-left:0px solid #dbdbdb;border-right:0px solid #dbdbdb;border-radius:0px; -moz-border-radius:0px; -webkit-border-radius:0px;} #top ul.nav li a { font:thin 12px/1.6em Helvetica, Arial, sans-serif;color:#ddd; } } #footer, #footer p { font:300 13px/1.4em 'Lato', arial, sans-serif;color:#ffffff; } #footer {border-top:0px solid #dbdbdb;border-bottom:0px solid ;border-left:0px solid ;border-right:0px solid ;border-radius:0px; -moz-border-radius:0px; -webkit-border-radius:0px;} .magazine #loopedSlider .content h2.title a { font:normal 24px/1em 'Lato', arial, sans-serif;color:#555555; } .wooslider-theme-magazine .slide-title a { font:normal 24px/1em 'Lato', arial, sans-serif;color:#555555; } .magazine #loopedSlider .content .excerpt p { font:normal 14px/1.5em 'Lato', arial, sans-serif;color:#555555; } .wooslider-theme-magazine .slide-content p, .wooslider-theme-magazine .slide-excerpt p { font:normal 14px/1.5em 'Lato', arial, sans-serif;color:#555555; } .magazine .block .post .title a {font:normal 18px/1.2em 'Lato', arial, sans-serif;color:#555555; } #loopedSlider.business-slider .content h2 { font:bold 24px/1em Arial, sans-serif;color:#ffffff; } #loopedSlider.business-slider .content h2.title a { font:bold 24px/1em Arial, sans-serif;color:#ffffff; } .wooslider-theme-business .has-featured-image .slide-title { font:bold 24px/1em Arial, sans-serif;color:#ffffff; } .wooslider-theme-business .has-featured-image .slide-title a { font:bold 24px/1em Arial, sans-serif;color:#ffffff; } #wrapper #loopedSlider.business-slider .content p { font:thin 13px/1.5em Arial, sans-serif;color:#cccccc; } .wooslider-theme-business .has-featured-image .slide-content p { font:thin 13px/1.5em Arial, sans-serif;color:#cccccc; } .wooslider-theme-business .has-featured-image .slide-excerpt p { font:thin 13px/1.5em Arial, sans-serif;color:#cccccc; } .archive_header { font:bold 18px/1em 'Lato', arial, sans-serif;color:#222222; } .archive_header {border-bottom:1px solid #e6e6e6;} </style>  <link rel="shortcut icon" href="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/03/tron-favicon.png"/>  <link href="https://web.archive.org/web/20210320060759cs_/https://tron-mainz.de/de/wp-content/gdprpatron/hts/tron-mainz.de/de/wp_content/themes/canvas/functions/css/shortcodes_css.css" rel="stylesheet" type="text/css"/>  <link href="https://web.archive.org/web/20210320060759cs_/https://tron-mainz.de/de/wp-content/gdprpatron/hts/tron-mainz.de/de/wp_content/themes/canvas/custom_css.css" rel="stylesheet" type="text/css"/>  <meta name="generator" content="Canvas 5.9.19"/> <meta name="generator" content="WooFramework 6.2.7"/>  <link href="https://web.archive.org/web/20210320060759cs_/https://tron-mainz.de/de/wp-content/gdprpatron/hts/fonts.googleapis.com/css_family_Lato_3A100_2C147212186.css" rel="stylesheet" type="text/css"/> <meta name="generator" content="Powered by WPBakery Page Builder - drag and drop page builder for WordPress."/> <style type="text/css" id="woo-header-css"> #logo .site-title a { color: #ffffff; } </style> <style> @media only screen and ( min-width: 768px ) { #nav-container { -moz-box-shadow: 0px 0px 0px #515151 !important; -webkit-box-shadow: 0px 0px 0px #515151 !important; box-shadow: 0px 0px 0px #515151 !important; } .primary-nav-container, .side-nav, #navigation ul.nav li a, #navigation ul.rss a, #navigation ul.cart a.cart-contents, #navigation .cart-contents #navigation ul.rss, #navigation ul.nav-search, #navigation ul.nav-search a { font-family: Lato ; font-size: 1.1em ; font-style: normal ; font-weight: 700; color : #164679 !important; } #navigation > section > .primary-nav-container ul.nav > .current-menu-item > a, #navigation > section > .primary-nav-container ul.nav > .current-menu-parent > a { color: #be3026 !important ; } #navigation > section > .primary-nav-container ul.nav > .menu-item.current-menu-item { background-color: #ffffff ; } #navigation > section > .primary-nav-container ul.nav > .current-menu-item > a { background-color: transparent ; } #navigation > section > .primary-nav-container ul.nav > .menu-item { background-color: #ffffff ; } #navigation .side-nav > ul > li > a { background-color: #ffffff !important ;color: #164679 !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item > a { background-color: transparent ; } #navigation ul.nav > li:hover > a, #navigation .side-nav > ul > li:hover > a { color: #9b0000 !important; background: !important; } #navigation .side-nav > ul > li > a:before { color: inherit !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item > a { text-shadow: inherit !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item { } #navigation > section > .primary-nav-container ul.nav > .menu-item:hover { } #navigation > section > .primary-nav-container ul.nav { display: inline-block; float: none !important ; } #navigation > section > .primary-nav-container ul.nav > li.menu-item { display: inline-block !important; float: none !important; vertical-align: middle !important; } #navigation > section { height: auto; text-align: right !important ; } #navigation > section > .primary-nav-container ul.nav { display: inline-block; float: none !important ; } #navigation > section > .primary-nav-container ul.nav > li.menu-item { display: inline-block !important; float: none !important; vertical-align: middle !important; } #navigation > section { height: 42px; text-align: right !important ; } #navigation > section > .primary-nav-container ul.nav > .menu-item > a { padding-top: px !important ; padding-bottom: px !important ; padding-right: px !important ; padding-left: px !important ; } #navigation > section > .primary-nav-container ul.nav > .menu-item { margin-top: px !important ; margin-bottom: px !important ; margin-right: px !important ; margin-left: px !important ; } #navigation > section > .primary-nav-container ul.nav > .menu-item, #navigation > section > .primary-nav-container ul.nav > .menu-item > a { border-radius: !important ; } #navigation > section > .primary-nav-container ul.nav > .menu-item { border: none !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item:hover, #navigation > section > .primary-nav-container ul.nav > .menu-item.hover { border-color: !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item.current-menu-item { border-color: #be3026 !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item- > a { font-family: ; font-size: px ; font-style: normal ; font-weight: 400; color : !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item-.current-menu-item > a { color: !important ; } #navigation > section > .primary-nav-container ul.nav > .menu-item-.current-menu-item { background-color: ; } #navigation > section > .primary-nav-container ul.nav > .menu-item-:hover > a { color: !important ; background-color: !important ; } 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solid ; border-left: px solid ; border-right: px solid ; } #navigation > section > .primary-nav-container ul.nav > .menu-item .sub-menu, #navigation .side-nav > .cart > li > ul, #navigation .side-nav > .nav-search > li > ul { background-color: #ffffff !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item .sub-menu > .menu-item:hover > a { color: #be3026 !important; } #navigation > section > .primary-nav-container ul.nav > .menu-item .sub-menu { padding-top: 0 !important; padding-bottom: 0 !important; } #navigation > section > .primary-nav-container ul.nav .sub-menu > .menu-item > a, #navigation > section > .side-nav .widget_shopping_cart { } #navigation > section > .primary-nav-container ul.nav .sub-menu, #navigation > section > .side-nav > .cart > li > ul { } body #navigation > section > .primary-nav-container ul.nav > .menu-item .sub-menu, #navigation > section > .side-nav > .cart > li > ul { border-radius: !important ; } #navigation > section > .primary-nav-container ul.nav > .menu-item .sub-menu > .menu-item:first-child { border-radius: 0 0 !important ; } #navigation > section > .primary-nav-container ul.nav > .menu-item .sub-menu > .menu-item:last-child { border-radius: 0 0 !important ; } #navigation > section > .primary-nav-container ul.nav { display: inline-block; vertical-align: middle; } #navigation > section > .side-nav { height:100%; vertical-align: middle; float:right; } #nav-container, #navigation { background-color: #ffffff !important; } #nav-container {border: none !important;}#nav-container { -moz-border-radius: 3px !important; -webkit-border-radius: 3px !important; border-radius: 3px !important; } #navigation ul.nav li ul { width:168px; font-size:14px; }#navigation ul.nav li { line-height:1.2em; }#navigation ul .sub-menu > li:first-child, #navigation ul .sub-menu > li:first-child > a { border-radius: 0 !important; -moz-border-radius: 0 !important; -webkit-border-radius: 0 !important; } #navigation { margin-top:0;margin-bottom:0; } #nav-container { margin-top: px; margin-bottom: px; } #navigation ul.nav > li > a { } #navigation ul.nav > li > a > i { margin-right: 5px; line-height: inherit; vertical-align: middle; color: ; } #navigation ul.nav > li > a:hover > i { color: ; } #navigation ul.nav > li.current-menu-item > a > i { color: ; } #navigation ul.nav > li ul li > a { line-height: ; } #navigation ul.nav > li ul li > a > i { float: left; margin-right: 5px; line-height: inherit; color: ; text-decoration: initial; } #nav-container #navigation ul#main-nav > li:first-child { border-left: none; } #navigation { transform: initial !important; }.primary-nav-container { display: inline-block; }#navigation ul.rss li.sub-rss a i,#navigation ul.rss li.sub-email a i{display:none;}body #navigation > section > .primary-nav-container ul.nav > .menu-item > .sub-menu > .menu-item:first { border-radius: 0 !important; } #navigation #main-nav > .menu-item > .sub-menu:before { content: ''; } #navigation #main-nav { font-size: 0; } #navigation #main-nav li { font-size: 14px; } #navigation #main-nav > .menu-item.parent:after { content: ''; position: absolute; top: 100%; display: none; } #navigation #main-nav > .menu-item.parent:hover:after { content: ''; position: absolute; top: 100%; display: block; } #navigation > section { height: auto; }#navigation .side-nav > .rss { position: relative; line-height: 100%; height: 100%; } #navigation .side-nav > .rss > li { line-height: 100%; height: 100%; } #navigation .side-nav > .rss > li > a { padding-top: 0; padding-bottom: 0; line-height: 100%; height: 100%; position: relative; overflow:hidden; } #navigation .side-nav > .rss > li > a:hover { text-decoration: none; } #navigation .side-nav > ul > li > a:before { position: absolute !important; top: 50% !important; margin-top: -0.5em !important; line-height:1; } #navigation .side-nav > .cart { line-height: 100%; height: 100% } #navigation .side-nav > .cart > li { height: 100% } #navigation .side-nav > .cart > li > .cart-contents { padding-top: 0; padding-bottom: 0; line-height: 100%; height: 100%; position: relative; } @media only screen and (min-width: 980px) { #navigation .side-nav > .cart > li { display: table; } #navigation .side-nav > .cart > li > a.cart-contents { display: table-cell; vertical-align: middle; } #navigation .side-nav > .cart > li > a.cart-contents:before { position: initial !important; } } #navigation ul.cart a.cart-contents + ul { box-sizing: content-box; } #navigation .side-nav > .nav-search { line-height: 100%; height: 100% } #navigation .side-nav > .nav-search > li { height: 100% } #navigation .side-nav > .nav-search > li > .search-contents { padding-top: 0; padding-bottom: 0; line-height: 100%; height: 100%; position: relative } #navigation .side-nav > ul > li > a:before { color: #be3026 !important; } #navigation .side-nav > ul > li > a:hover:before { color: !important; } #navigation #main-nav > .menu-item > a > span { vertical-align: middle; } .side-nav ul ul input , .side-nav ul ul :before { color: !important ; } } @media only screen and ( max-width: 767px ) { #navigation ul.nav > li > a > i { display: none; } #navigation ul.nav > li ul li > a > i { display: none } } </style> <style type="text/css">/* *** NEWS BOX - WP DYNAMIC CUSTOM THEME *** */ .lcnb_wpdt_theme .lcnb_loading { background: url('https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/gdprpatron/hts/tron-mainz.de/de/wp_content/plugins/swift_box_wp/js/sb//img/loader_d_gif.gif') no-repeat center center transparent; } .lcnb_wpdt_theme article.lcnb_news, .lcnb_wpdt_theme .lcnb_exp_block { background-color: #ffffff; } .lcnb_wpdt_theme.lcnb_wrap.lcnb_uniblock .lcnb_inner_wrapper { border-radius: 0px; } .lcnb_wpdt_theme.lcnb_wrap.lcnb_uniblock .lcnb_news, .lcnb_wpdt_theme.lcnb_wrap.lcnb_boxed article.lcnb_news, .lcnb_wpdt_theme.lcnb_wrap.lcnb_uniblock .lcnb_exp_block { border: 0px solid #D5D5D5; -moz-transition: 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} /* source logos */ .lcnb_wpdt_theme.lcnb_src_logo .lcnb_type_twitter > div { background-image: url("https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/gdprpatron/hts/tron-mainz.de/de/wp_content/plugins/swift_box_wp/js/sb//img/social_src_logos/dark/twitter_png.png"); } .lcnb_wpdt_theme.lcnb_src_logo .lcnb_type_rss > div { background-image: url("https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/gdprpatron/hts/tron-mainz.de/de/wp_content/plugins/swift_box_wp/js/sb//img/social_src_logos/dark/rss_png.png"); } .lcnb_wpdt_theme.lcnb_src_logo .lcnb_type_pinterest > div { background-image: url("https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/gdprpatron/hts/tron-mainz.de/de/wp_content/plugins/swift_box_wp/js/sb//img/social_src_logos/dark/pinterest_png.png"); } .lcnb_wpdt_theme.lcnb_src_logo .lcnb_type_facebook > div { background-image: 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class="nb_news_wrap" style="display: none;" link_target="_blank" exp_img_pos="inside"><article datetime="2021-03-01T05:55:49+00:00"> <header>Bundesverdienstkreuz für Ugur Sahin und Özlem Türeci</header> <section><p>Unsere herzlichen Glückwünsche: TRON-Gründer Ugur Sahin und Özlem Türeci erhalten das Bundesverdienstkreuz für die kurzfristige Entwicklung und Zulassung eines Impfstoffes gegen Covid-19 mit ihrem Unternehmen BioNTech, wie das Bundespräsidialamt mitteilte. Türeci und Sahin hätten durch ihren "unermüdlichen Einsatz" einen "entscheidenden Beitrag zur Eindämmung der Corona-Pandemie geleistet".</p><p>Die Verleihung des höchsten deutschen Verdienstordens an das Unternehmerpaar durch Bundespräsident Frank-Walter Steinmeier findet den Angaben zufolge am 19. März im Schloss Bellevue im Beisein von Bundeskanzlerin Angela Merkel statt. Es ist demnach die erste persönliche Ordensaushändigung des Bundespräsidenten in diesem Jahr.</p></section><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2021/02/Ugur_Oezlem_TRON-scaled.jpg" class="lcnb_main_img"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2021/03/01/bundesverdienstkreuz-fuer-ugur-sahin-und-oezlem-tuereci/" class="lcnb_inline_link"></a> </article><article datetime="2021-02-22T07:45:08+00:00"> <header>Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA</header> <section><p>In this recent study published in European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI), researchers from TRON, JGU Medical Center and BioNTech employed an in vitro transcribed mRNA encoding for sodium iodide symporter (NIS) to efficiently visualize and quantify the biodistribution of NIS RNA-lipoplex nanoparticles targeted to spleen or lung. Tissues expressing the RNA-encoded NIS were rapidly and accurately identified via in vivo small animal PET/MRI upon radioactive Iodine-124 administration providing a novel powerful tool for monitoring the biodistribution of RNA-loaded nanoparticles.</p><p>Read more in the original publication: <a href="https://web.archive.org/web/20210320060759/https://doi.org/10.1186/s13550-021-00753-2">https://doi.org/10.1186/s13550-021-00753-2</a></p></section><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2016/05/iStock_000007160860Medium.jpg" class="lcnb_main_img"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2021/02/22/iodine-124-pet-quantification-of-organ-specific-delivery-and-expression-of-nis-encoding-rna/" class="lcnb_inline_link"></a> </article><article datetime="2021-02-05T06:43:47+00:00"> <header>Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates</header> <section><p>Within the last year, a few infections with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) quickly turned into the global COVID-19 pandemic infecting and threatening death for millions of people all over the globe. The viral spike protein is responsible for viral binding and entry to host cells and thus mediates infection. Hence, the protein is also of particular interest and the major target for recently approved mRNA vaccines or neutralizing antibodies.<br>In this study, Barbara Schrörs and her colleagues gathered 147,413 genomic assemblies and 2,393 NGS sequencing datasets to detect non-synonymous spike protein mutations and infer their frequency within a given sample and the effect on potential antibody binding sites and known T cell epitopes. They confirm a low mutation rate, but also discovered an increase of mutation rates of the spike protein over time. In addition, some of the discovered mutations might have an effect on antibody binding or T-cell recognition and thus have an impact on the efficacy of current or upcoming vaccines.<br>The authors conclude that the results demonstrate the increasing importance of monitoring SARS-CoV-2 sequences for an early detection of variants that require adaptations in preventive and therapeutic strategies.</p><p>The study was published as a pre-print in BioRxiv (<a href="https://web.archive.org/web/20210320060759/https://www.biorxiv.org/content/10.1101/2021.02.04.429765v1">https://www.biorxiv.org/content/10.1101/2021.02.04.429765v1</a>).</p><p>[Image: SARS-CoV-2 spike-glycoprotein (PDB: <a href="https://web.archive.org/web/20210320060759/https://pdb101.rcsb.org/motm/246">https://pdb101.rcsb.org/motm/246</a>)]</p></section><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2021/02/SARSCoV2_BioRxiv.png" class="lcnb_main_img"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2021/02/05/large-scale-analysis-of-sars-cov-2-spike-glycoprotein-mutants-demonstrates-the-need-for-continuous-screening-of-virus-isolates/" class="lcnb_inline_link"></a> </article><article datetime="2021-02-01T14:24:42+00:00"> <header>Akademiepreis des Landes Rheinland-Pfalz für Ugur Sahin und Özlem Türeci</header> <section><p>Dr. Özlem Türeci und Prof. Dr. Ugur Sahin wurden für ihre außergewöhnlichen Leistungen, die zur Entwicklung eines Impfstoffes gegen das Corona-Virus geführt haben, mit dem Akademiepreis des Landes Rheinland-Pfalz für innovative und zukunftsweisende Forschung ausgezeichnet.</p><p>Im Namen aller Mitarbeiterinnen und Mitarbeiter von TRON gratulieren wir Dr. Özlem Türeci und Professor Ugur Sahin, unserem Mitgründer, langjährigen Wissenschaftlichen Geschäftsführer und heutigen Berater, sehr herzlich zum Erhalt des Akademiepreises.</p><p>Finden Sie weitere Informationen <a href="https://web.archive.org/web/20210320060759/https://idw-online.de/de/news762042">hier</a>.</p></section><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2021/02/Ugur_Oezlem_TRON-scaled.jpg" class="lcnb_main_img"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2021/02/01/akademiepreis-des-landes-rheinland-pfalz-fuer-ugur-sahin-und-oezlem-tuereci/" class="lcnb_inline_link"></a> </article><article datetime="2021-02-01T10:29:00+00:00"> <header>TRON-Wissenschaftler leisten Beitrag zur neuesten BioNTEch/Pfizer-Publikation in Nature</header> <section><p>Herzlichen Glückwunsch, Fulvia! TRON-Forscherin Fulvia Vascotto unterstützte das Team um Annette B. Vogel und Ugur Sahin, das kürzlich präklinische Ergebnisse, die zur rasanten Entwicklung des inzwischen weltweit eingesetzten mRNA-basierten Covid-19-Impfstoffs COMIRNATY (BNT162b2) von BioNTech/Pfizer in <em>Nature </em>veröffentlichte. Die kürzlich erschienene Arbeit zeigt Daten zur Immunantwort von zwei Impfstoffkandidaten (BNT162b1 und BNT162b2) in Tiermodellen. In Mäusen löst eine intramuskuläre Einzeldosis eines der beiden Kandidaten eine dosisabhängige Antikörperreaktion mit hohen Viruseintritt-Inhibitionstitern und starken TH1-Typ CD4+ und IFNg+ CD8+ T-Zell-Reaktionen aus. Die Erst- und Auffrischungsimpfung von Rhesusaffen mit den BNT162b-Kandidaten löst im geometrischen Mittel SARS-CoV-2-neutralisierende Titer aus, die 8,2- bis 18,2-mal so hoch sind wie die eines SARS-CoV-2-Rekonvaleszenz-Panels aus humanem Serum.<br>Den Originalartikelfinden Sie <a href="https://web.archive.org/web/20210320060759/https://www.nature.com/articles/s41586-021-03275-y" rel="noopener noreferrer" target="_blank">hier</a>.</p></section><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2018/06/iStock_000011686797crop.jpg" class="lcnb_main_img"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2021/02/01/tron-wissenschaftler-leisten-beitrag-zur-neuesten-biontech-pfizer-publikation-in-nature/" class="lcnb_inline_link"></a> </article><article datetime="2021-01-08T13:53:02+00:00"> <header>Novel RNA-based therapy for treatment of autoimmune diseases</header> <section><p>Loss of immunological self-tolerance followed by attack of self-reactive T cells to target organs plays a major role in the formation of autoimmune diseases such as multiple sclerosis (MS). In a very recent study published in Science, our researchers (in collaboration with Johannes Gutenberg University Medical Center and BioNTech) employed a non-inflammatory RNA vaccine that targets self-antigens to antigen presenting cells without inducing co-stimulation. This therapy was able to modulate self-reactive T cells, induce regulatory T cells and re-establish self-tolerance leading to suppression of the disease in various mouse models of MS. The results of this study may help the development of potent therapies against complex autoimmune diseases.</p><p>A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis<br>Krienke et al.<br><a href="https://web.archive.org/web/20210320060759/https://science.sciencemag.org/content/371/6525/145.full">DOI: 10.1126/science.aay3638</a></p><p><a class="lbwrap">Image created by Christina Krienke.</a></p></section><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2021/01/Krienke2021Science.jpg" class="lcnb_main_img"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2021/01/08/novel-rna-based-therapy-for-treatment-of-autoimmune-diseases/" class="lcnb_inline_link"></a> </article></div></div><script type="text/javascript">jQuery(document).ready(function() 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class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element vc_custom_1484733720313"> <div class="wpb_wrapper"> <h4 style="text-align: right"><span style="color: #164679">Ankündigungen</span></h4> </div> </div> <div class="mpc-carousel__wrapper mpc-waypoint"><div id="mpc_carousel_posts-476055913fdf1e4" class="mpc-carousel-posts mpc-init mpc-init mpc-transition mpc-overlay--fade mpc-item--fade mpc-layout--style_9 " data-mpcslick="{"infinite":true,"autoplay":false,"slidesToShow":1,"slidesToScroll":1,"centerMode":false,"initialSlide":0}" data-slick-cols="1"><div onclick="" class="mpc-post"><div class="mpc-post__wrapper"><div class="mpc-post__content mpc-transition"><h3 class="mpc-post__heading mpc-transition"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2020/10/09/9506/" title="International initiative TESLA identifies parameters for cancer vaccine or cell therapy advancement">International initiative TESLA identifies parameters for cancer vaccine or cell therapy advancement</a></h3><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2020/10/09/9506/" target="" title="International initiative TESLA identifies parameters for cancer vaccine or cell therapy advancement" class="mpc-button mpc-init mpc-transition "><div class="mpc-button__content mpc-effect-type--stay mpc-effect-side--right"><span class="mpc-button__title mpc-transition">Weiterlesen</span><i class="mpc-button__icon mpc-transition "></i></div><div class="mpc-button__background mpc-transition mpc-effect-type--fade mpc-effect-side--in"></div></a></div></div></div><div onclick="" class="mpc-post"><div class="mpc-post__wrapper"><div class="mpc-post__content mpc-transition"><h3 class="mpc-post__heading mpc-transition"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2020/08/13/multi-omics-characterization-of-the-4t1-murine-mammary-gland-tumor-model/" title="Multi-omics characterization of the 4T1 murine mammary gland tumor model">Multi-omics characterization of the 4T1 murine mammary gland tumor model</a></h3><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2020/08/13/multi-omics-characterization-of-the-4t1-murine-mammary-gland-tumor-model/" target="" title="Multi-omics characterization of the 4T1 murine mammary gland tumor model" class="mpc-button mpc-init mpc-transition "><div class="mpc-button__content mpc-effect-type--stay mpc-effect-side--right"><span class="mpc-button__title mpc-transition">Weiterlesen</span><i class="mpc-button__icon mpc-transition "></i></div><div class="mpc-button__background mpc-transition mpc-effect-type--fade mpc-effect-side--in"></div></a></div></div></div><div onclick="" class="mpc-post"><div class="mpc-post__wrapper"><div class="mpc-post__content mpc-transition"><h3 class="mpc-post__heading mpc-transition"><a 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class="mpc-button__title mpc-transition">Weiterlesen</span><i class="mpc-button__icon mpc-transition "></i></div><div class="mpc-button__background mpc-transition mpc-effect-type--fade mpc-effect-side--in"></div></a></div></div></div><div onclick="" class="mpc-post"><div class="mpc-post__wrapper"><div class="mpc-post__content mpc-transition"><h3 class="mpc-post__heading mpc-transition"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2018/09/11/ugur-sahin-co-authors-nature-reviews-drug-discovery-article-2/" title="Ugur Sahin co-authors Nature Reviews Drug Discovery article">Ugur Sahin co-authors Nature Reviews Drug Discovery article</a></h3><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/blog/2018/09/11/ugur-sahin-co-authors-nature-reviews-drug-discovery-article-2/" target="" title="Ugur Sahin co-authors Nature Reviews Drug Discovery article" class="mpc-button mpc-init mpc-transition "><div class="mpc-button__content 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vc-gitem-zone-height-mode-auto vc_gitem-is-link" style="background-image: url('https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/03/201701iStock_000019334103Large_new2-1-1024x685.jpg') !important;"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/forschung/" title="Forschung" class="vc_gitem-link vc-zone-link"></a><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2017/03/201701iStock_000019334103Large_new2-1-1024x685.jpg" class="vc_gitem-zone-img" alt=""><div class="vc_gitem-zone-mini"><div class="vc_gitem_row vc_row vc_gitem-row-position-bottom"><div class="vc_col-sm-12 vc_gitem-col vc_gitem-col-align-"><div class="vc_custom_heading homegrid vc_custom_1487599158807 vc_gitem-post-data vc_gitem-post-data-source-post_title"><div style="font-size: 1em;color: #ffffff;line-height: 1.2em;text-align: left;font-family:Lato;font-weight:700;font-style:normal"><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/forschung/" class="vc_gitem-link" title="Forschung">Forschung</a></div></div></div></div></div></div></div></div><div class="vc_clearfix"></div></div></div></div> </div> </div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 vc_col-has-fill mpc-column"><div class="vc_column-inner vc_custom_1490175985570"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element vc_custom_1488993584448"> <div class="wpb_wrapper"> <h4 style="text-align: right"><span style="color: #164679">TRON in den Nachrichten</span></h4> </div> </div> <div class="mpc-carousel__wrapper mpc-waypoint"><div id="mpc_carousel_posts-66055913fe930d" class="mpc-carousel-posts mpc-init mpc-init mpc-transition mpc-overlay--fade mpc-item--fade mpc-layout--style_9 " 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href="https://web.archive.org/web/20210320060759/http://www.unimedizin-mainz.de/vz/aktuelles/pressemitteilungen/single-ansicht/article/prof-ugur-sahin-erhaelt-european-research-council-erc-advanced-grant-2017-fuer-personalisierte-krebsimpfstoffe.html?L=0&cHash=83fb5cff9970130a1d8032fbfe77c094" target="" title="Prof. Ugur Sahin erhält European Research Council (ERC) Advanced Grant 2017 für personalisierte Krebsimpfstoffe" class="mpc-button mpc-init mpc-transition "><div class="mpc-button__content mpc-effect-type--stay mpc-effect-side--right"><span class="mpc-button__title mpc-transition">Weiterlesen</span><i class="mpc-button__icon mpc-transition "></i></div><div class="mpc-button__background mpc-transition mpc-effect-type--fade mpc-effect-side--in"></div></a></div></div></div><div onclick="" class="mpc-post"><div class="mpc-post__wrapper"><div class="mpc-post__content mpc-transition"><h3 class="mpc-post__heading mpc-transition"><a 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class="wpb_text_column wpb_content_element vc_custom_1485098483478"> <div class="wpb_wrapper"> <p><span style="color: #164679">TRON-Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH ist ein biopharmazeutisches Forschungsinstitut, das neue Diagnostika und Arzneimittel für die Therapie von Krebs und anderen Erkrankungen mit hohem medizinischem Bedarf entwickelt. Der Schwerpunkt von TRON liegt in der Entwicklung neuer Plattformen für personalisierte Therapiekonzepte und Biomarker, und somit in der Überführung grundlagenorientierter Forschung in die Entwicklung neuer Arzneimittel. In Zusammenarbeit mit akademischen Institutionen, Biotechnologiefirmen und der pharmazeutischen Industrie kommen in der Forschung am TRON modernste Technologien zum Einsatz. Zudem stellt TRON seine einzigartige Expertise und Infrastruktur der Entwicklung von innovativen Arzneimitteln zur besseren Patientenversorgung zur Verfügung.<br> </span></p> </div> </div> </div></div></div></div></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div> </section> <div class="fix"></div> </article> </section> </div> </div>  <div id="footer-widgets-container"> <section id="footer-widgets" class="col-full col-4"> <div class="block footer-widget-1"> <div id="text-2" class="widget widget_text"> <div class="textwidget"><p><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/wp-content/uploads/2016/10/wappen.jpg" alt="Gefördert vom Land Rheinland-Pfalz"/></p> </div> </div> </div> <div class="block footer-widget-2"> <div id="text-3" class="widget widget_text"> <div class="textwidget"><p><img src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/wp-content/uploads/2016/10/bmbf-logo-de.jpg" alt="Gefördert vom Bundesministerium für Bildung und Forschung"/></p> </div> </div> </div> <div class="block footer-widget-3"> <div id="text-5" class="widget widget_text"> <div class="textwidget"><p><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/DFG-logo_foerderung.jpg"><img loading="lazy" class="alignnone size-medium wp-image-9186" src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/DFG-logo_foerderung-300x85.jpg" alt="" width="300" height="85" srcset="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/DFG-logo_foerderung-300x85.jpg 300w, https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/DFG-logo_foerderung-1024x290.jpg 1024w, https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/DFG-logo_foerderung-768x217.jpg 768w, https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/DFG-logo_foerderung.jpg 1057w" sizes="(max-width: 300px) 100vw, 300px"/></a></p> </div> </div> </div> <div class="block footer-widget-4"> <div id="text-7" class="widget widget_text"> <div class="textwidget"><p><a href="https://web.archive.org/web/20210320060759/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/EC-logo_DE.jpg"><img loading="lazy" class="alignnone wp-image-9187" src="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/EC-logo_DE-300x208.jpg" alt="" width="160" height="111" srcset="https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/EC-logo_DE-300x208.jpg 300w, https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/EC-logo_DE-1024x709.jpg 1024w, https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/EC-logo_DE-768x531.jpg 768w, https://web.archive.org/web/20210320060759im_/https://tron-mainz.de/de/wp-content/uploads/sites/9/2020/08/EC-logo_DE.jpg 1104w" sizes="(max-width: 160px) 100vw, 160px"/></a></p> </div> </div> </div> <div class="fix"></div> </section> </div>  <div id="footer-container"> <footer id="footer" class="col-full"> <div id="copyright" class="col-left"> <p><p>© 2021 TRON Mainz. 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