Assessment of Aminopolyether on 18F-FDG Samples

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"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="Assessment of Aminopolyether on 18F-FDG Samples"> <meta name="citation_author" content="Renata L. C. Leão"> <meta name="citation_author" content="João E. Nascimento"> <meta name="citation_author" content="Natalia C. E. S. Nascimento"> <meta name="citation_author" content="Elaine S. Vasconcelos"> <meta name="citation_author" content="Mércia L. Oliveira"> <meta name="citation_publication_date" content="2019/08/04"> <meta name="citation_journal_title" content="International Journal of Pharmacological and Pharmaceutical Sciences"> <meta name="citation_volume" content="13"> <meta name="citation_issue" content="9"> <meta name="citation_firstpage" content="407"> <meta name="citation_lastpage" content="410"> <meta name="citation_pdf_url" content="https://publications.waset.org/10010770/pdf"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value=""> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 33093</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Assessment of Aminopolyether on 18F-FDG Samples</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Renata%20L.%20C.%20Le%C3%A3o">Renata L. C. Leão</a>, <a href="https://publications.waset.org/search?q=Jo%C3%A3o%20E.%20Nascimento"> João E. Nascimento</a>, <a href="https://publications.waset.org/search?q=Natalia%20C.%20E.%20S.%20Nascimento"> Natalia C. E. S. Nascimento</a>, <a href="https://publications.waset.org/search?q=Elaine%20S.%20Vasconcelos"> Elaine S. Vasconcelos</a>, <a href="https://publications.waset.org/search?q=M%C3%A9rcia%20L.%20Oliveira"> Mércia L. Oliveira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The quality control procedures of a radiopharmaceutical include the assessment of its chemical purity. The method suggested by international pharmacopeias consists of a thin layer chromatographic run. In this paper, the method proposed by the United States Pharmacopeia (USP) is compared to a direct method to determine the final concentration of aminopolyether in Fludeoxyglucose (<sup>18</sup>F-FDG) preparations. The approach (no chromatographic run) was achieved by placing the thin-layer chromatography (TLC) plate directly on an iodine vapor chamber. Both methods were validated and they showed adequate results to determine the concentration of aminopolyether in <sup>18</sup>F-FDG preparations. However, the direct method is more sensitive, faster and simpler when compared to the reference method (with chromatographic run), and it may be chosen for use in routine quality control of <sup>18</sup>F-FDG.</p> <iframe src="https://publications.waset.org/10010770.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Chemical%20purity" title="Chemical purity">Chemical purity</a>, <a href="https://publications.waset.org/search?q=Kryptofix%20222" title=" Kryptofix 222"> Kryptofix 222</a>, <a href="https://publications.waset.org/search?q=thin%20layer%20chromatography" title=" thin layer chromatography"> thin layer chromatography</a>, <a href="https://publications.waset.org/search?q=validation." title=" validation. "> validation. </a> </p> <p class="card-text"><strong>Digital Object Identifier (DOI):</strong> <a href="https://doi.org/10.5281/zenodo.3462085" target="_blank">doi.org/10.5281/zenodo.3462085</a> </p> <a href="https://publications.waset.org/10010770/assessment-of-aminopolyether-on-18f-fdg-samples" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10010770/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10010770/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10010770/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10010770/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10010770/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10010770/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10010770/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10010770/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10010770/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10010770/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10010770.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">837</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] Fowler, J.S.; Ido, T. Initial and Subsequent Approach for the Synthesis of 18FDG. Seminars in Nuclear Medicine, 32(1),6-12, 2002. <br>[2] Nakao, R., Kida, T., Suzuki, K. Factors affecting quality control of 18FFDG injection: bacterial endotoxins test, aluminum ions test and HPLC analysis for FDG and ClDG. Applied Radiation and Isotopes, 62, 889-895, 2005. <br>[3] Yu, S. Review of 18F-FDG synthesis and quality control. Biomedical Imaging and Intervention Journal, 2(4), 1-11, 2006. <br>[4] Hoh, C.K. Clinical use of FDG PET. Nuclear Medicine and Biology, 34(7), 737-742, 2007. <br>[5] United States Pharmacopeia Convention - USP. 33th ed. Rockville: United States Pharmacopeial Convention, 2010. <br>[6] European Pharmacopeia – EP. 7th ed. London: Stationery Office, 2010. <br>[7] ANVISA. Resolução da Diretoria Colegiada - RDC n°. 166, 24 de julho de 2017. <br>[8] Food and Drugs Administration (FDA). Guidance for industry: Analytical procedures and methods validation, Ago. 2000. <br>[9] ICH- Internacional Conference on Harmonisation. Guidance for Industry Q2B. Test on Validation of Analytical Procedures. 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Assessment of Aminopolyether on 18F-FDG Samples