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What Is Primary Hyperoxaluria Type 1 (PH1)? | OXLUMO® (lumasiran)
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If you have PH1, it is important to work with your doctor.</h3> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="columns image-text" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2023-04/oxlumo-targets-oxalate.png" width="1806" height="1542" alt="" loading="lazy" typeof="foaf:Image" /></div> </article></div> <div class="field--item"><h2>PH1 causes the body to produce too much oxalate, which can lead to kidney stones and kidney damage</h2> <ul> <li><span>Oxalate is a waste product that is mostly removed by the kidneys through urine</span></li> <li><span>When too much oxalate is made, it can damage the kidneys</span></li> <li>When the disease advances and the kidneys aren't working right, oxalate can collect in the blood</li> <li>Oxalate may then deposit in other organs and cause injury and permanent damage</li> </ul> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="tiny_center pb-32" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2>Symptoms of PH1 and how it can affect the body</h2></div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="columns icons pb-0" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/stone-icon2.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><p><strong>Kidney stones are the most common symptom of PH1</strong> Any kidney stone in a child or adolescent, or recurring kidney stones in adults, can be a sign of PH1.</p> </div> <div class="field--item"><article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/kidney-icon2.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><p><strong>Too much oxalate in the body can lead to permanent damage</strong> When you have too much oxalate in the body, this can lead to permanent damage of the kidneys and other areas of the body. PH1 may require ongoing management and monitoring with your doctor and a well-coordinated care team. This may include nephrologists, urologists, nurses, and other healthcare providers.</p> </div> <div class="field--item"><article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/kidney-icon3.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><p><strong>PH1 is more than a kidney stone disease</strong> Even if someone is not experiencing kidney stones, too much oxalate can cause serious damage to their kidneys or other organs.</p> </div> <div class="field--item"><article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/woman-icon.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><p><strong>PH1 can affect each person differently</strong> These are not all the signs and symptoms of PH1. It is important to work closely with your doctor to develop a personalized management plan.</p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="pt-24" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><p>These are not all the signs and symptoms of PH1.</p></div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="callout educator" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/educator-icon.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><h2 class="text-align-center">CONNECT WITH AN ALNYLAM EDUCATOR</h2> <p class="text-align-center">Learn about primary hyperoxaluria type 1 (PH1) and treatment with OXLUMO® from one of our trained Alnylam Patient Education Liaisons (PELs).</p> <p class="note text-align-center">PELs are employees of Alnylam Pharmaceuticals. They are not acting as healthcare providers and are not part of your healthcare team.</p> <p class="text-align-center"><a class="btn" href="/patient-education-liaisons">Let’s Connect</a></p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="columns support" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/dialog-icon-large.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><h2>We’re here to help you access therapy</h2> <p>Find support services that can help you and your family during treatment with OXLUMO.</p> <p class="mobile_center"><a class="btn btn-secondary" href="/patient-support">Let’s Go</a></p> </div> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2020-10/sign-up-icon.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><h2>Sign up for updates</h2> <p>Learn more by signing up to receive important content.</p> <p class="mobile_center"><a class="btn btn-secondary" href="/sign-up-for-updates">Sign Me Up</a></p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="callout green" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><a href="/about-oxlumo"> <span class="inner"> <span class="left_text"> <p><em>NEXT:</em></p> <p class="hide_mobile">LEARN ABOUT THE FIRST FDA-APPROVED MEDICATION FOR PH1</p> </span> <span class="hide_mobile align-center media"> <img src="/sites/default/files/2020-07/slash.svg" alt="" typeof="foaf:Image"> </span> <span class="right_text">LEARN ABOUT<br> <span class="arrow">OXLUMO® <span style="white-space:nowarp;">(lumasiran)</span></span> </span> </span> </a></div> </div> </div> </div> </div> </div> </section> </div> </div> <div property="schema:text" class="field--item"></div> </div> </article> </div> </div> </section> <div class="region region-content-bottom"> <div id="block-importantsafetyinformation" class="isi block block-block-content block-block-content63d76fc1-b7f0-475f-917b-98825b6fba84"> <span class="close-isi"></span> <span class="open-isi"></span> <div class="field--item"><p class="h3">IMPORTANT SAFETY INFORMATION</p> <p>The most common side effect of OXLUMO® (lumasiran) is injection site reaction (redness, swelling, pain, bruising, itching, and discoloration at the site of injection). These are not all the possible side effects of OXLUMO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <strong><a class="js-open-inter" href="https://www.fda.gov/medwatch" target="_blank">www.fda.gov/medwatch</a></strong>, or call <strong><a href="tel:1-800-FDA-1088">1‑800‑FDA‑1088</a></strong>.</p> <p>OXLUMO has not been studied in pregnant or breastfeeding women. Talk to your doctor about the risk of taking OXLUMO if you are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.</p> <p class="h3">WHAT IS OXLUMO?</p> <p>OXLUMO is a prescription medicine for the treatment of primary hyperoxaluria type 1 (PH1) to lower oxalate in urine and blood in children and adults. </p> <p><strong style="color: inherit;">For additional information about OXLUMO, please see full <a href="https://www.alnylam.com/oxlumo-us-prescribing-information" target="_blank">Prescribing Information</a>.</strong></p> </div> </div><div id="block-corporateinterstitial" class="block block-block-content block-block-content6e2edfba-b157-4b45-b715-dc959aab885e"> <div class="field--item"><div class="popup" id="corp_inter"> <div class="wrapper"><a class="close js-close-popup" href="#">×</a> <p class="h3">You are now leaving OXLUMO.com</p> <p>You are now being directed to another Alnylam website.</p> <p><a class="btn link js-close-popup" href="#">Visit Site</a> <a class="btn btn-secondary js-close-popup" href="#">Cancel</a></p> </div> </div> <div class="popup" id="inter"> <div class="wrapper"><a class="close js-close-popup" href="#">×</a> <p class="h3">You are now leaving OXLUMO.com</p> <p>Links to all outside sites are provided as a reference for our visitors. 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