Day One | 5th Wet AMD & Diabetic Eye Disease Drug Development

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type-page status-publish has-post-thumbnail hentry" id="fl-post-595" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-595 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="595"><div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-0hw24zvboeyq fl-row-default-height fl-row-align-center" data-node="0hw24zvboeyq"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-nz4qyksblfdg" data-node="nz4qyksblfdg"> <div class="fl-col fl-node-rc98sjxi5qmh fl-col-bg-photo fl-col-bg-overlay" data-node="rc98sjxi5qmh"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-k2ajvo5zfrpx" data-node="k2ajvo5zfrpx"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">DAY ONE</span> </h2> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-5bb333c7ecf02 fl-row-default-height fl-row-align-center" data-node="5bb333c7ecf02"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-5bb333c7ede95" data-node="5bb333c7ede95"> <div class="fl-col fl-node-5bb333c7edf1b fl-col-bg-color fl-col-small" data-node="5bb333c7edf1b"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-5bb333f298e9c" data-node="5bb333f298e9c"> <div class="fl-module-content fl-node-content"> <a href="https://wet-amd-drug-development.com/day-one/" id="ee-link-5bb333f298e9c"> <div class="eehw-link"> <div class="link-url"> <h2>Day One</h2> </div> <div class="link-date"> <p>Wednesday, March 19 2025</p> </div> </div> </a> </div> </div> </div> </div> <div class="fl-col fl-node-5bb333c7edf21 fl-col-bg-color fl-col-small" data-node="5bb333c7edf21"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-5bb333cc51b0a" data-node="5bb333cc51b0a"> <div class="fl-module-content fl-node-content"> <a href="https://wet-amd-drug-development.com/day-two/" id="ee-link-5bb333cc51b0a"> <div class="eehw-link"> <div class="link-url"> <h2>Day Two</h2> </div> <div class="link-date"> <p>Thursday, March 20 2025</p> </div> </div> </a> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-8jkuht4ar2bn" data-node="8jkuht4ar2bn"> <div class="fl-col fl-node-kivb4q7lx6m5 fl-col-bg-color fl-col-has-cols" data-node="kivb4q7lx6m5"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-y4tpnus12rx9" data-node="y4tpnus12rx9"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #fae5e5"> <h3> <span class="time"> </span> <span style="color:#ff0000;"><b>7.30 am Check-In & Coffee + Light Breakfast</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:25 am </span> <span style="color:#00426e;"><b>Chair鈥檚 Opening Remarks</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #00426e"> <h3> <span class="time"> </span> <center><span style="color:#FFFFFF;font-size: 20px;"><b>RECENT ADVANCEMENTS & EMERGING THERAPIES TO IMPROVE TREATMENT OPTIONS FOR WET AMD & DIABETIC EYE DISEASE</center></span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:30 am </span> <span style="color:#00426e;"><b>Prolonging Drug Efficacy in Wet AMD: Innovations in Formulation & Delivery</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22927" class="view-speaker" speaker-id="22927"><span>Lokendra Bengani</span></a></em> Senior Scientist, EyePoint Pharmaceuticals </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Examine the role of ocular pharmacogenetics in extending the duration of drug efficacy, focusing on how genetic variations can influence drug metabolism and response in the eye</li> <li>Explore advanced delivery systems which allow for higher drug concentrations and targeted delivery to enhance treatment longevity</li> <li>Discuss the use of polymers in drug formulations to create sustained-release mechanisms, improving the half-life and bioavailability of ocular drugs by ensuring a gradual and controlled release of the active ingredients</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:00 am </span> <span style="color:#00426e;"><b>An Overview on Pathways & Outcomes of Wet AMD & Diabetic Retinopathy</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22934" class="view-speaker" speaker-id="22934"><span>Michael Tolentino</span></a></em> Co-Founder & Chief Innovation Officer, Aviceda Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Exploring molecular pathways contributing to diabetic retinopathy and wet AMD to understand variations in treatment efficacy</li> <li>Identifying key biomarkers that guide the selection of effective therapies and support combination approaches</li> <li>Addressing unmet needs by informing drug development with insights on patients who are unresponsive to current treatments</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> <span style="color:#00426e;"><b>ONS-5010: The First On-Label Bevacizumab Treatment for Wet AMD</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22939" class="view-speaker" speaker-id="22939"><span>Surendra Sharma</span></a></em> Senior Vice President, Medical Affairs, Outlook Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Addressing regulatory challenges to meet FDA approval</li> <li>Leveraging EMA support to establish ONS-5010 as a global standard for wet AMD treatment</li> <li>Explaining the product details, offering an affordable and effective alternative to compete in the crowded anti-VEGF market and reshape retinal care paradigms</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #fae5e5"> <h3> <span class="time"> </span> <span style="color:#ff0000;"><b>10.00 am Speed Networking</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="color: rgb(255, 0, 0);">An optimal chance to network one-to-one with leading retinal vascular experts working across early discovery, preclinical and clinical stages. Learn how your peers are developing better anti-VEGF drugs, new targets, new modalities and clinical</span></p> <p><span style="color: rgb(255, 0, 0);">biomarkers and endpoints for better patient treatment and early disease detection.</span></p> </div>  </div> <div class="inner-agenda" style="background: #fae5e5"> <h3> <span class="time"> </span> <span style="color:#ff0000;"><b>10.30 am Morning Break & Refreshments</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #00426e"> <h3> <span class="time"> </span> <center><span style="color:#FFFFFF;font-size: 20px;"><b>ANTI-VEGF COMBINATIONS & BEYOND: COMBATING RESISTANCE TO IMPROVE STANDARD OF CARE</span></b></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:00 am </span> <span style="color:#00426e;"><b>Addressing Treatment Resistance & Improving Outcomes in Retinal Vein Occlusion with a Novel Multimodal Eye Drop Therapy</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22940" class="view-speaker" speaker-id="22940"><span>Irach Taraporewala</span></a></em> CEO, EOM Pharmaceuticals </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Overview of the E147 eye drop, a second-generation product targeting retinal vein occlusions with a unique mechanism of action</li> <li>Highlight the positive results from the pilot study and plans for upcoming US trials in retinal vein occlusion and diabetic retinopathy</li> <li>Discuss how the E147 eye drop鈥檚 ability to target multiple growth factors involved in vascular and fibrotic processes could help address the issue of treatment resistance and fibrosis associated with current anti-VEGF therapies</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:30 am </span> <span style="color:#00426e;"><b>RO-104, A First/Best-In-Class Trispecific Monotherapy with the Potential to Offer Superior & Sustained Vision for Wet AMD & DME Patients</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22941" class="view-speaker" speaker-id="22941"><span>Ramanath Bhandari</span></a></em> Chief Executive Officer, RevOpsis </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Leveraging the RevMod platform with fully human phage display library to identify novel CDRs instrumental in treating diseases of significant unmet need in ophthalmology and oncology</li> <li>Looking at the lead ophthalmology asset from RevMod platform, a fully human trispecific antibody (RO-104) targeting 3 clinically validated pathways in AMD and DME as monotherapy, potentially offering superior and sustained vision over standard of care</li> <li>Demonstrating early efficacy, safety, and tolerability of RO-104 across multiple animal (rat and NHP) models with a robust FIH study planned to start in Q4 2025 and designed to enable accelerated development path to pivotal trials and registration</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:00 pm </span> <span style="color:#00426e;"><b>Panel Discussion: How Can We Practically Implement New Treatments for Retinal Vascular Disorders, Streamlining Clinical Trials to Set Yourself Up for Success?</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22942" class="view-speaker" speaker-id="22942"><span>Fabio Baschiera</span></a></em> Global Clinical & Ophthalmology Leader, Bayer </li> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22939" class="view-speaker" speaker-id="22939"><span>Surendra Sharma</span></a></em> Senior Vice President, Medical Affairs, Outlook Therapeutics </li> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22940" class="view-speaker" speaker-id="22940"><span>Irach Taraporewala</span></a></em> CEO, EOM Pharmaceuticals </li> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker25052" class="view-speaker" speaker-id="25052"><span>Faryan Tayyari</span></a></em> Director, Clinical Development Strategy Lead, Boehringer Ingelheim </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>How can you streamline trial design, incorporating new drug and technology advancements, to ensure a smoother transition through clinical phases for retinal therapies?</li> <li>What are the best strategies for forming partnerships and collaborations to support clinical development and commercialization efforts?</li> <li>How can patient engagement and feedback be integrated into the development process to enhance the efficacy and acceptance of new retinal therapies?</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #fae5e5"> <h3> <span class="time"> </span> <span style="color:#ff0000;"><b>12.45 pm Lunch & Networking with Scientific Poster Session</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="color: rgb(255, 0, 0);">This is an informal session to help you connect with your peers in a relaxed atmosphere to continue forging new and beneficial relationships. With an audience of translational, clinical, and commercial experts eager to hear the latest advancements in wet AMD & diabetic eye disease therapeutic development, you will have the opportunity to display a poster presenting your own work and innovations.</span></p> </div>  </div> <div class="inner-agenda" style="background: #00426e"> <h3> <span class="time"> </span> <center><span style="color:#FFFFFF;font-size: 20px;"><b>TRANSLATIONAL INNOVATIONS, PROACTIVE NPDR MANAGEMENT, & SUSTAINED-RELEASE SOLUTIONS TO PREVENT VISION LOSS & ENHANCE PATIENT CARE</span></b></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:00 pm </span> <span style="color:#00426e;"><b>Overcoming Translational Challenges in DR & DME: Holistic Approaches for Better Models</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22945" class="view-speaker" speaker-id="22945"><span>Anton Lennikov</span></a></em> Faculty instructor, Schepens Eye Research Institute </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Develop appropriate in vivo models that accurately replicate human disease conditions for diabetic retinopathy (DR) and diabetic macular edema (DME), addressing the limitations and variability of current rodent models</li> <li>Integrate computational and in vitro methods alongside in vivo studies to create a comprehensive, holistic approach for predicting drug efficacy and improving the translational success of preclinical findings</li> <li>Enhance collaboration between basic scientists and clinicians to refine these models, ensuring they capture the complex phenotypes of DR and DME, ultimately facilitating smoother transitions to clinical trials</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:30 pm </span> <span style="color:#00426e;"><b>Activating Soluble Guanylate Cyclase for Non-Proliferative Diabetic Retinopathy (NPDR) Treatment</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22942" class="view-speaker" speaker-id="22942"><span>Fabio Baschiera</span></a></em> Global Clinical & Ophthalmology Leader, Bayer </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Presenting preclinical data on runcaciguat鈥檚 ability to activate soluble guanylate cyclase, aiming to improve retinal blood flow and reduce inflammation in NPDR</li> <li>Designing the Phase 2 NEON-NPDR trial to demonstrate how runcaciguat鈥檚 preclinical efficacy translates into clinical benefits for patients with NPDR</li> <li>Reflecting on current trial results that indicate potential improvements in retinal health and a reduced risk of vision-threatening complications</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:00 pm </span> <span style="color:#00426e;"><b>Sustained-Release Innovation for Wet AMD & DR with an Intravitreal Implant</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Discuss the limitations of current treatments for retinal diseases like wet AMD and Diabetic Retinopathy, which require frequent intravitreal injections, leading to increased risk of complications and patient discomfort</li> <li>Explore the advantages of AXPAXLI (OTX-TKI), a bioresorbable hydrogel implant designed to provide sustained release of axitinib, offering a broad antiangiogenic effect with the potential to extend treatment intervals to 6 months or longer</li> <li>Highlight the innovative product design, including the small fiber format, which aims to minimize visual impact and eliminate the need for preservatives, potentially improving patient outcomes and adherence</li> </ul> </div>  </div> <div class="inner-agenda" style="background: #fae5e5"> <h3> <span class="time"> </span> <span style="color:#ff0000;"><b>3.30 pm Afternoon Break & Refreshments</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #00426e"> <h3> <span class="time"> </span> <center><span style="color:#FFFFFF;font-size: 20px;"><b>ADVANCING EARLY INTERVENTION & HOME MONITORING TECHNOLOGIES FOR IMPROVED PATIENT OUTCOMES</span></b></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:00 pm </span> <span style="color:#00426e;"><b>Fireside Chat: Early Intervention vs. Monitoring in NPDR: Navigating the Controversy</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker25053" class="view-speaker" speaker-id="25053"><span>Ash Jayagopal</span></a></em> Chief Scientific & Development Officer, Opus Genetics </li> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22928" class="view-speaker" speaker-id="22928"><span>Michael lp</span></a></em> Medical Director, Doheny Image Reading Center </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Debate the merits of early treatment versus monitoring in non-proliferative diabetic retinopathy (NPDR), considering the potential to alter disease progression and prevent vision-threatening events</li> <li>Examine the significant industry investment in early intervention strategies, such as Genentech鈥檚 port delivery systems, and their potential to reduce the incidence of diabetic macular edema (DME) and other complications</li> <li>Analyze real-world data and expert opinions, noting that while historically most experts suggest a wait-and-see approach, the growing market and advancements in anti-VEGF therapies suggest a shift towards proactive treatment</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:45 pm </span> <span style="color:#00426e;"><b>Revolutionizing Wet AMD Care with Home Monitoring for Enhanced Patient Outcomes</span></b> </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://wet-amd-drug-development.com/speakers/#speaker22949" class="view-speaker" speaker-id="22949"><span>Jeffrey Heier</span></a></em> Chief Scientific Officer, Ocular Therapeutix, Inc. </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Expanding access to intravitreal injections and progressing towards at-home drug delivery methods to increase treatment accessibility and convenience for patients</li> <li>Implementing at-home OCT technologies and AI-driven telemonitoring systems for real-time monitoring of Wet AMD, significantly reducing the need for frequent clinic visits while maintaining stable visual acuity</li> <li>Reducing patient burden through personalized treatment algorithms that tailor regimens based on individual disease patterns, treatment responses, and medication durability, ultimately improving compliance and quality of life</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 5:15 pm </span> <span style="color:#00426e;"><b>Chair鈥檚 Closing Remarks</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 5:20 pm </span> <span style="color:#00426e;"><b>End of Conference Day One</span></b> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> <div class="fl-module fl-module-separator 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li').length>1){$('#wp-admin-bar-fl-builder-frontend-duplicate-link').appendTo('#wp-admin-bar-fl-builder-frontend-edit-link-default').css('padding-top','5px').css('border-top','2px solid #1D2125').css('margin-top','5px')}}};$(function(){FLBuilderLayout.init();});})(jQuery);;;;(function($){FLBuilderMenu=function(settings){this.nodeId=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-menu';this.type=settings.type;this.mobileToggle=settings.mobile;this.mobileBelowRow=settings.mobileBelowRow;this.mobileFlyout=settings.mobileFlyout;this.breakPoints=settings.breakPoints;this.mobileBreakpoint=settings.mobileBreakpoint;this.currentBrowserWidth=$(window).width();this.postId=settings.postId;this.mobileStacked=settings.mobileStacked;this._initMenu();$(window).on('resize',$.proxy(function(e){var width=$(window).width();if(width!=this.currentBrowserWidth){this.currentBrowserWidth=width;this._initMenu();this._clickOrHover();} this._resizeFlyoutMenuPanel();},this));$(window).on('scroll',$.proxy(function(e){this._resizeFlyoutMenuPanel();},this));$('body').on('click',$.proxy(function(e){if('undefined'!==typeof FLBuilderConfig){return;} var activeMobileMenu=$(this.wrapperClass+' .fl-menu-mobile-toggle.fl-active');if(activeMobileMenu.length&&('expanded'!==this.mobileToggle)){$(activeMobileMenu).trigger('click');} $(this.wrapperClass).find('.fl-has-submenu').removeClass('focus');$(this.wrapperClass).find('.fl-has-submenu .sub-menu').removeClass('focus');},this));$(this.wrapperClass+' ul.menu > li:last-child').on('focusout',$.proxy(function(e){if($(this.wrapperClass).find('.fl-menu-mobile-toggle').hasClass('fl-active')&&('expanded'!==this.mobileToggle)){if(!$(e.relatedTarget).parent().hasClass('menu-item')){$(this.wrapperClass).find('.fl-menu-mobile-toggle').trigger('click');}}},this));};FLBuilderMenu.prototype={nodeClass:'',wrapperClass:'',type:'',breakPoints:{},$submenus:null,_isMobile:function(){return this.currentBrowserWidth<=this.breakPoints.small?true:false;},_isMedium:function(){return this.currentBrowserWidth<=this.breakPoints.medium?true:false;},_isLarge:function(){return this.currentBrowserWidth<=this.breakPoints.large?true:false;},_isMenuToggle:function(){if(('always'==this.mobileBreakpoint||(this._isMobile()&&'mobile'==this.mobileBreakpoint)||(this._isMedium()&&'medium-mobile'==this.mobileBreakpoint)||(this._isLarge()&&'large-mobile'==this.mobileBreakpoint))&&($(this.wrapperClass).find('.fl-menu-mobile-toggle').is(':visible')||'expanded'==this.mobileToggle)){return true;} return false;},_initMenu:function(){this._setupSubmenu();this._menuOnFocus();this._menuOnEscape();this._submenuOnClick();if($(this.nodeClass).length&&this.type=='horizontal'){this._initMegaMenus();} if(this._isMenuToggle()||this.type=='accordion'){$(this.wrapperClass).off('mouseenter mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').find('a').first().attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5ba0ab906f568',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'198',mobileStacked:true,});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-5ba0ae36c560f .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} if(this.hasAdminBar&&this.win.width()<=600){wpAdminBarHeight=Math.floor($('#wpadminbar').outerHeight());} totalHeaderHeight=Math.floor(beforeHeaderHeight+headerHeight);if(headerHeight>0){var headerParent=this.header.parent(),headerParentTopPadding=0;if($(headerParent).is('body')){headerParentTopPadding=Math.floor(headerHeight-wpAdminBarHeight);}else{headerParentTopPadding=Math.floor(headerHeight-bodyTopPadding-wpAdminBarHeight);} $(headerParent).css('padding-top',(headerParentTopPadding-beforeHeaderFix)+'px');this.header.css({'-webkit-transform':'translate(0px, -'+totalHeaderHeight+'px)','-ms-transform':'translate(0px, -'+totalHeaderHeight+'px)','transform':'translate(0px, -'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var image=$(this),maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.css('max-height',shrinkImageHeight);}});this.header.find('.fl-row-content-wrap').each(function(){var row=$(this);if(parseInt(row.css('padding-bottom'))>5){row.addClass('fl-theme-builder-header-shrink-row-bottom');} if(parseInt(row.css('padding-top'))>5){row.addClass('fl-theme-builder-header-shrink-row-top');}});this.header.find('.fl-module-content').each(function(){var module=$(this);if(parseInt(module.css('margin-bottom'))>5){module.addClass('fl-theme-builder-header-shrink-module-bottom');} if(parseInt(module.css('margin-top'))>5){module.addClass('fl-theme-builder-header-shrink-module-top');}});}}else if(hasClass){this.header.find('img').css('max-height','');this._removeShrink();} if('undefined'===typeof(e)&&$('body').hasClass('fl-fixed-width')){if(!this.overlay){this._adjustHeaderHeight();}}},_removeShrink:function(){var rows=this.header.find('.fl-row-content-wrap'),modules=this.header.find('.fl-module-content');rows.removeClass('fl-theme-builder-header-shrink-row-bottom');rows.removeClass('fl-theme-builder-header-shrink-row-top');modules.removeClass('fl-theme-builder-header-shrink-module-bottom');modules.removeClass('fl-theme-builder-header-shrink-module-top');this.header.removeClass('fl-theme-builder-header-shrink');},_setImageMaxHeight:function(){var head=$('head'),stylesId='fl-header-styles-'+this.header.data('post-id'),styles='',images=this.header.find('.fl-module-content img');if($('#'+stylesId).length){return;} images.each(function(i){var image=$(this),height=image.height(),node=image.closest('.fl-module').data('node'),className='fl-node-'+node+'-img-'+i,maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.addClass(className);styles+='.'+className+' { max-height: '+(height?height:image[0].height)+'px }';}});if(''!==styles){head.append('<style id="'+stylesId+'">'+styles+'</style>');}},_removeImageMaxHeight:function(){$('#fl-header-styles-'+this.header.data('post-id')).remove();},};$(function(){FLThemeBuilderHeaderLayout.init();});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-483zljbvnith .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-tks846yhzeu5 .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){$(function(){$('.fl-map').on('click',function(){$(this).find('iframe').css('pointer-events','auto');});});})(jQuery);</script><script type="text/javascript" src="https://onsite.optimonk.com/script.js?account=197068" async></script></body> </html>

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Day One | 5th Wet AMD & Diabetic Eye Disease Drug Development