CINXE.COM

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Pro;white-space:normal;">A chi dice “impossibile, inattuabile, irrealistico” rispondiamo: </div>  <div class="tp-caption tp-resizeme" id="slide-2-layer-2" data-x="['left','left','left','left']" data-hoffset="['100','120','100','60']" data-y="['top','top','top','top']" data-voffset="['196','196','160','130']" data-width="['550','550','345','266']" data-height="none" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":0,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 6; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 35px; line-height: 40px; font-weight: 700; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;">Sfida Accettata </div>  <div class="tp-caption tp-resizeme" id="slide-2-layer-3" data-x="['left','left','left','left']" data-hoffset="['100','120','100','60']" data-y="['top','top','top','top']" data-voffset="['255','255','215','180']" data-fontsize="['22','22','18','18']" data-width="['550','550','345','266']" data-height="none" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":0,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 7; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 22px; line-height: 33px; font-weight: 300; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;white-space:normal;">Stiamo sviluppando una nuova classe di farmaci innovativi, denominati composti terapeutici per la RNAi (Interferenza dell’RNA), che riteniamo abbiano il potenziale di cambiare la vita delle persone affette da malattie rare. </div>  <div class="tp-caption rev-btn " id="slide-2-layer-4" data-x="['left','left','left','left']" data-hoffset="['100','120','100','60']" data-y="['top','top','top','top']" data-voffset="['415','415','435','435']" data-width="none" data-height="none" data-whitespace="nowrap" data-type="button" data-actions='[{"event":"click","action":"simplelink","target":"_self","url":"\/chi-siamo","delay":""}]' data-responsive_offset="on" data-responsive="off" data-frames='[{"delay":0,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"},{"frame":"hover","speed":"0","ease":"Linear.easeNone","to":"o:1;rX:0;rY:0;rZ:0;z:0;","style":"c:rgb(255,255,255);bs:solid;bw:0 0 0 0;"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[12,12,12,12]" data-paddingright="[35,35,35,35]" data-paddingbottom="[12,12,12,12]" data-paddingleft="[35,35,35,35]" style="z-index: 8; white-space: nowrap; font-size: 18px; line-height: 30px; font-weight: 600; color: rgba(255,255,255,1); letter-spacing: px;font-family:Source Sans Pro;background-color:rgb(0,153,204);border-color:rgb(0,153,204);outline:none;box-shadow:none;box-sizing:border-box;-moz-box-sizing:border-box;-webkit-box-sizing:border-box;cursor:pointer;">Chi è Alnylam › </div> </li>  <li data-index="rs-3" data-transition="fade" data-slotamount="default" data-hideafterloop="0" data-hideslideonmobile="off" data-easein="default" data-easeout="default" data-masterspeed="300" data-thumb="https://www.alnylam.it/sites/default/files/revslider/image/scorrimento-intestazione-scienziato.jpg" data-rotate="0" data-saveperformance="off" data-title="Slide" data-param1="" data-param2="" data-param3="" data-param4="" data-param5="" data-param6="" data-param7="" data-param8="" data-param9="" data-param10="" data-description="">  <img src="https://www.alnylam.it/sites/default/files/revslider/image/scorrimento-intestazione-scienziato.jpg" alt="https://www.alnylam.it/sites/default/files/revslider/image/scorrimento-intestazione-scienziato.jpg" title="scorrimento-intestazione-scienziato.jpg" data-bgposition="center top" data-bgfit="cover" data-bgrepeat="no-repeat" class="rev-slidebg" data-no-retina>   <div class="tp-caption tp-resizeme" id="slide-3-layer-1" data-x="['left','left','left','left']" data-hoffset="['100','120','100','60']" data-y="['top','top','top','top']" data-voffset="['100','100','60','60']" data-fontsize="['28','28','18','18']" data-lineheight="['33','33','33','30']" data-width="['550','550','345','288']" data-height="['none','none','none','121']" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":10,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 5; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 28px; line-height: 33px; font-weight: 400; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;white-space:normal;">Siamo focalizzati su malattie che hanno opzioni di trattamento limitate o addirittura non ne hanno alcuna. </div>  <div class="tp-caption tp-resizeme" id="slide-3-layer-2" data-x="['left','left','left','left']" data-hoffset="['100','120','100','60']" data-y="['top','top','top','top']" data-voffset="['220','220','185','174']" data-width="['550','550','345','324']" data-height="['none','none','none','41']" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":10,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 6; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 33px; line-height: 40px; font-weight: 700; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;">La Nostra Pipeline </div>  <div class="tp-caption tp-resizeme" id="slide-3-layer-3" data-x="['left','left','left','left']" data-hoffset="['100','120','100','60']" data-y="['top','top','top','top']" data-voffset="['279','280','245','239']" data-fontsize="['22','22','18','18']" data-lineheight="['33','33','33','30']" data-width="['550','550','345','266']" data-height="none" data-whitespace="nowrap" data-type="text" data-responsive_offset="on" data-frames='[{"delay":10,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"}]' data-textAlign="['inherit','inherit','inherit','inherit']" data-paddingtop="[0,0,0,0]" data-paddingright="[0,0,0,0]" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]" style="z-index: 7; min-width: 550px; max-width: 550px; white-space: nowrap; font-size: 22px; line-height: 33px; font-weight: 300; color: #ffffff; letter-spacing: 0px;font-family:Source Sans Pro;white-space:normal;">Include progetti di RNAi in fase sperimentale per farmaci genetici, malattie cardiometaboliche, malattie epatiche infettive e malattie del sistema nervoso centrale (SNC) e malattie oculari. </div>  <div class="tp-caption rev-btn " id="slide-3-layer-4" data-x="['left','left','left','left']" data-hoffset="['100','120','100','60']" data-y="['top','top','top','top']" data-voffset="['432','440','450','453']" data-width="none" data-height="none" data-whitespace="nowrap" data-type="button" data-actions='[{"event":"click","action":"simplelink","target":"_self","url":"\/la-nostra-pipeline","delay":""}]' data-responsive_offset="on" data-responsive="off" data-frames='[{"delay":10,"speed":300,"frame":"0","from":"opacity:0;","to":"o:1;","ease":"Power3.easeInOut"},{"delay":"wait","speed":300,"frame":"999","to":"opacity:0;","ease":"Power3.easeInOut"},{"frame":"hover","speed":"0","ease":"Linear.easeNone","to":"o:1;rX:0;rY:0;rZ:0;z:0;","style":"c:rgb(255,255,255);bs:solid;bw:0 0 0 0;"}]' 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.tp-bullet-title{top:25px; left:50%; right:auto; transform:translateX(-50%) translateY(10px);-webkit-transform:translateX(-50%) translateY(10px)}.ares.nav-dir-horizontal.nav-pos-ver-top .tp-bullet-title:after{border-width:0 10px 10px 10px; border-color:transparent transparent rgba(255,255,255,0.75) transparent; right:auto; left:50%; margin-left:-10px; bottom:auto; top:-10px}.ares.nav-dir-horizontal.nav-pos-ver-top .tp-bullet.selected:hover .tp-bullet-title:after{border-color:transparent transparent rgba(255,204,0,1) transparent}.ares.nav-dir-horizontal.nav-pos-ver-top .tp-bullet:hover .tp-bullet-title{transform:translateX(-50%) translatey(0px); -webkit-transform:translateX(-50%) translatey(0px)}</style> </div> </section> </div> <div class="field field--name-field-body field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--page-title paragraph--view-mode--default"> <div class="field field--name-field-page-ti field--type-text field--label-hidden field--item">ABBIAMO L’ASPIRAZIONE DI CAMBIARE IL MODO DI TRATTARE LE MALATTIE</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--centered-text paragraph--view-mode--default"> <div class="field field--name-field-centered-text field--type-text-long field--label-hidden field--item"><p>Alnylam è impegnata nella traslazione dell’interferenza dell’RNA (RNAi) in una nuova classe di farmaci innovativi per pazienti con opzioni terapeutiche limitate o inadeguate. Basati su una ricerca che è stata insignita del premio Nobel, i composti terapeutici per la RNAi rappresentano un approccio clinicamente validato per il trattamento di un’ampia gamma di malattie gravi e debilitanti.</p> <p>Fondata nel 2002, Alnylam persegue la coraggiosa visione di trasformare possibilità scientifiche in realtà attraverso una piattaforma di sviluppo innovativa che ha portato ad una estesa pipeline di farmaci in fase di sperimentazione e 5 programmi clinici registrativi e numerosi programmi di sviluppo clinico.</p> </div> </div> </div> </div> <div class="field field--name-field-big-numbers field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>2<span>k</span></div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Dipendenti </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">20</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Paesi </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">11</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Programmi attualmente in sviluppo clinico</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">5</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Prodotti approvati</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>35</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Studi clinici condotti fino a oggi</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--big-numbers paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>8</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Esposizione in anni</div> </div> </div> </div> <div class="field field--name-field-big-numbers-slider field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--slideshow paragraph--view-mode--default"> <div class="slick blazy slick--field slick--field-slides slick--field-slides--default slick--skin--default slick--optionset--custom" data-blazy="" id="slick-paragraph-slideshow-slides-default-22-1"> <div id="slick-paragraph-slideshow-slides-default-22-1-slider" data-slick="{"autoplay":true,"pauseOnHover":false,"pauseOnFocus":false,"autoplaySpeed":9000,"arrows":false,"dots":true,"fade":true,"speed":1000,"count":6}" class="slick__slider"> <div class="slick__slide slide slide--0"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>2<span>k</span></div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Dipendenti </div> </div> </div> <div class="slick__slide slide slide--1"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">20</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Paesi </div> </div> </div> <div class="slick__slide slide slide--2"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">11</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Programmi attualmente in sviluppo clinico</div> </div> </div> <div class="slick__slide slide slide--3"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item">5</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Prodotti approvati*</div> </div> </div> <div class="slick__slide slide slide--4"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>35</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Studi clinici condotti fino a oggi</div> </div> </div> <div class="slick__slide slide slide--5"> <div class="paragraph paragraph--type--slide paragraph--view-mode--default"> <div class="field field--name-field-big-number field--type-text field--label-hidden field--item"><span>></span>8</div> <div class="field field--name-field-number-caption field--type-text field--label-hidden field--item">Esposizione in anni</div> </div> </div> </div> <nav role="navigation" class="slick__arrow"> <button type="button" data-role="none" class="slick-prev" aria-label="Previous" tabindex="0">Previous</button> <button type="button" data-role="none" class="slick-next" aria-label="Next" tabindex="0">Next</button> </nav> </div> </div> </div> </div> <div class="field field--name-field-body-lower field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--footnote paragraph--view-mode--default"> <div class="field field--name-field-footnote field--type-text field--label-hidden field--items"> <div class="field--item">Aggiornamento a Gennaio 2023</div> </div> </div> </div> </div> <div class="field field--name-field-body-full-width field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--rnai paragraph--view-mode--default"> <div class="field field--name-field-rnai-text field--type-text-long field--label-hidden field--items"> <div class="field--item"><h3>RNAi: UNA RIVOLUZIONE IN BIOLOGIA CHE NASCE DA UNA RICERCA INSIGNITA DEL PREMIO NOBEL</h3> <p>L’interferenza dell’RNA (RNAi) è una svolta nella comprensione della regolazione dei geni nelle cellule. Rappresenta inoltre un approccio completamente diverso alla scoperta e allo sviluppo dei farmaci. Il Premio Nobel per la Fisiologia o la Medicina del 2006, attribuito a Craig Mello e Andrew Fire, ha riconosciuto l’importanza fondamentale della scoperta dell’RNAi.</p> <p><a href="/la-nostra-scienza">Maggiori Informazioni ›</a></p> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--focus paragraph--view-mode--default"> <div class="field field--name-field-focus field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2>I NOSTRI OBIETTIVI</h2> <p>La nostra pipeline di farmaci basati sulla tecnologia dell'RNAi si concentra su malattie con elevate esigenze non soddisfatte in campo medico, appartenenti a 4 aree terapeutiche strategiche (Strategic Therapeutic Areas, STArs): farmaci genetici, malattie cardiometaboliche, malattie epatiche infettive e malattie del sistema nervoso centrale (SNC) e malattie oculari.</p> <p><a href="/la-nostra-pipeline">Visulalizza la nostra pipeline ›</a></p> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--join-our-team paragraph--view-mode--default"> <div class="field field--name-field-join-our-team field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2 class="show-mobile">ENTRA NEL NOSTRO TEAM</h2> <div class="join-img wpb_animate_when_almost_visible wpb_left-to-right left-to-right wpb_column vc_column_container vc_col-sm-5 vc_col-lg-7 vc_col-md-6 vc_col-xs-12"><img alt="cpl-italian" data-entity-type="file" data-entity-uuid="aaa0248d-b1e4-4747-a079-c48a969f8719" height="auto" src="/sites/default/files/inline-images/cpl-italian-2023.png" width="auto" loading="lazy" /></div> <div class="join-text"> <h2 class="hide-mobile">ENTRA NEL NOSTRO TEAM</h2> <p>Stiamo crescendo velocemente ed assumendo persone in Nord America, Europa, Asia e America Latina per numerosi ruoli. 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