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vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Exemples de glycoprotéines</span> </button> <ul id="toc-Exemples_de_glycoprotéines-sublist" class="vector-toc-list"> <li id="toc-Fibronectine" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Fibronectine"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Fibronectine</span> </div> </a> <ul id="toc-Fibronectine-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Laminine" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Laminine"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Laminine</span> </div> </a> <ul id="toc-Laminine-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Anticorps" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Anticorps"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.3</span> <span>Anticorps</span> </div> </a> <ul id="toc-Anticorps-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Implication_dans_des_processus_biologiques[1]" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Implication_dans_des_processus_biologiques[1]"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Implication dans des processus biologiques<sup><span>[</span>1<span>]</span></sup></span> </div> </a> <button aria-controls="toc-Implication_dans_des_processus_biologiques[1]-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Implication dans des processus biologiques<sup><span>[</span>1<span>]</span></sup></span> </button> <ul id="toc-Implication_dans_des_processus_biologiques[1]-sublist" class="vector-toc-list"> <li id="toc-Inflammation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Inflammation"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Inflammation</span> </div> </a> <ul id="toc-Inflammation-sublist" class="vector-toc-list"> <li id="toc-Sélectine_et_Intégrine" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Sélectine_et_Intégrine"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1.1</span> <span>Sélectine et Intégrine</span> </div> </a> <ul id="toc-Sélectine_et_Intégrine-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Fécondation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Fécondation"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Fécondation</span> </div> </a> <ul id="toc-Fécondation-sublist" class="vector-toc-list"> <li id="toc-ZP3" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#ZP3"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2.1</span> <span>ZP3</span> </div> </a> <ul id="toc-ZP3-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-PH-30" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#PH-30"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2.2</span> <span>PH-30</span> </div> </a> <ul id="toc-PH-30-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Implication_dans_des_maladies[2]" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Implication_dans_des_maladies[2]"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Implication dans des maladies<sup><span>[</span>2<span>]</span></sup></span> </div> </a> <button aria-controls="toc-Implication_dans_des_maladies[2]-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Implication dans des maladies<sup><span>[</span>2<span>]</span></sup></span> </button> <ul id="toc-Implication_dans_des_maladies[2]-sublist" class="vector-toc-list"> <li id="toc-Cancer" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cancer"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Cancer</span> </div> </a> <ul id="toc-Cancer-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Défaut_d’adhérence_des_leucocytes_de_type_II" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Défaut_d’adhérence_des_leucocytes_de_type_II"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Défaut d’adhérence des leucocytes de type II</span> </div> </a> <ul id="toc-Défaut_d’adhérence_des_leucocytes_de_type_II-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hémoglobinurie_paroxystique_nocturne_(PNH)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hémoglobinurie_paroxystique_nocturne_(PNH)"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Hémoglobinurie paroxystique nocturne (PNH)</span> </div> </a> <ul id="toc-Hémoglobinurie_paroxystique_nocturne_(PNH)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Arthrite_rhumatoïde" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Arthrite_rhumatoïde"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.4</span> <span>Arthrite rhumatoïde</span> </div> </a> <ul id="toc-Arthrite_rhumatoïde-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Notes_et_références" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Notes_et_références"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Notes et références</span> </div> </a> <ul id="toc-Notes_et_références-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Voir_aussi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Voir_aussi"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Voir aussi</span> </div> </a> <button aria-controls="toc-Voir_aussi-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Voir aussi</span> </button> <ul id="toc-Voir_aussi-sublist" class="vector-toc-list"> <li id="toc-Articles_connexes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Articles_connexes"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Articles connexes</span> </div> </a> <ul id="toc-Articles_connexes-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liens_externes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Liens_externes"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Liens externes</span> </div> </a> <ul id="toc-Liens_externes-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sommaire" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Basculer la table des matières" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Basculer la table des matières</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Glycoprotéine</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Aller à un article dans une autre langue. Disponible en 54 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-54" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">54 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A8%D8%B1%D9%88%D8%AA%D9%8A%D9%86_%D8%B3%D9%83%D8%B1%D9%8A" title="بروتين سكري – arabe" lang="ar" hreflang="ar" data-title="بروتين سكري" data-language-autonym="العربية" data-language-local-name="arabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ast mw-list-item"><a href="https://ast.wikipedia.org/wiki/Glicoprote%C3%ADna" title="Glicoproteína – asturien" lang="ast" hreflang="ast" data-title="Glicoproteína" data-language-autonym="Asturianu" data-language-local-name="asturien" class="interlanguage-link-target"><span>Asturianu</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%93%D0%BB%D1%96%D0%BA%D0%B0%D0%BF%D1%80%D0%B0%D1%82%D1%8D%D1%96%D0%BD%D1%8B" title="Глікапратэіны – biélorusse" lang="be" hreflang="be" data-title="Глікапратэіны" data-language-autonym="Беларуская" data-language-local-name="biélorusse" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%93%D0%BB%D0%B8%D0%BA%D0%BE%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD" title="Гликопротеин – bulgare" lang="bg" hreflang="bg" data-title="Гликопротеин" data-language-autonym="Български" data-language-local-name="bulgare" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Glikoprotein" title="Glikoprotein – bosniaque" lang="bs" hreflang="bs" data-title="Glikoprotein" data-language-autonym="Bosanski" data-language-local-name="bosniaque" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Glicoprote%C3%AFna" title="Glicoproteïna – catalan" lang="ca" hreflang="ca" data-title="Glicoproteïna" data-language-autonym="Català" data-language-local-name="catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Glykoproteiny" title="Glykoproteiny – tchèque" lang="cs" hreflang="cs" data-title="Glykoproteiny" data-language-autonym="Čeština" data-language-local-name="tchèque" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Glykoprotein" title="Glykoprotein – danois" lang="da" hreflang="da" data-title="Glykoprotein" data-language-autonym="Dansk" data-language-local-name="danois" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Glykoproteine" title="Glykoproteine – allemand" lang="de" hreflang="de" data-title="Glykoproteine" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%93%CE%BB%CF%85%CE%BA%CE%BF%CF%80%CF%81%CF%89%CF%84%CE%B5%CE%90%CE%BD%CE%B7" title="Γλυκοπρωτεΐνη – grec" lang="el" hreflang="el" data-title="Γλυκοπρωτεΐνη" data-language-autonym="Ελληνικά" data-language-local-name="grec" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Glycoprotein" title="Glycoprotein – anglais" lang="en" hreflang="en" data-title="Glycoprotein" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Glucoprote%C3%ADna" title="Glucoproteína – espagnol" lang="es" hreflang="es" data-title="Glucoproteína" data-language-autonym="Español" data-language-local-name="espagnol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Gl%C3%BCkoproteiinid" title="Glükoproteiinid – estonien" lang="et" hreflang="et" data-title="Glükoproteiinid" data-language-autonym="Eesti" data-language-local-name="estonien" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Glukoproteina" title="Glukoproteina – basque" lang="eu" hreflang="eu" data-title="Glukoproteina" data-language-autonym="Euskara" data-language-local-name="basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%AF%D9%84%DB%8C%DA%A9%D9%88%D9%BE%D8%B1%D9%88%D8%AA%D8%A6%DB%8C%D9%86" title="گلیکوپروتئین – persan" lang="fa" hreflang="fa" data-title="گلیکوپروتئین" data-language-autonym="فارسی" data-language-local-name="persan" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Glykoproteiini" title="Glykoproteiini – finnois" lang="fi" hreflang="fi" data-title="Glykoproteiini" data-language-autonym="Suomi" data-language-local-name="finnois" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Glicoprote%C3%ADna" title="Glicoproteína – galicien" lang="gl" hreflang="gl" data-title="Glicoproteína" data-language-autonym="Galego" data-language-local-name="galicien" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%92%D7%9C%D7%99%D7%A7%D7%95%D7%A4%D7%A8%D7%95%D7%98%D7%90%D7%99%D7%9F" title="גליקופרוטאין – hébreu" lang="he" hreflang="he" data-title="גליקופרוטאין" data-language-autonym="עברית" data-language-local-name="hébreu" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Glikoprotein" title="Glikoprotein – hongrois" lang="hu" hreflang="hu" data-title="Glikoprotein" data-language-autonym="Magyar" data-language-local-name="hongrois" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Glikoprotein" title="Glikoprotein – indonésien" lang="id" hreflang="id" data-title="Glikoprotein" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonésien" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Glicoproteina" title="Glicoproteina – italien" lang="it" hreflang="it" data-title="Glicoproteina" data-language-autonym="Italiano" data-language-local-name="italien" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E7%B3%96%E3%82%BF%E3%83%B3%E3%83%91%E3%82%AF%E8%B3%AA" title="糖タンパク質 – japonais" lang="ja" hreflang="ja" data-title="糖タンパク質" data-language-autonym="日本語" data-language-local-name="japonais" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%93%D0%BB%D0%B8%D0%BA%D0%BE%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%B4%D1%82%D0%B5%D1%80" title="Гликопротеидтер – kazakh" lang="kk" hreflang="kk" data-title="Гликопротеидтер" data-language-autonym="Қазақша" data-language-local-name="kazakh" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-kn mw-list-item"><a href="https://kn.wikipedia.org/wiki/%E0%B2%97%E0%B3%8D%E0%B2%B2%E0%B3%88%E0%B2%95%E0%B3%8B%E0%B2%AA%E0%B3%8D%E0%B2%B0%E0%B3%8B%E0%B2%9F%E0%B3%80%E0%B2%A8%E0%B3%8D%E2%80%8C" title="ಗ್ಲೈಕೋಪ್ರೋಟೀನ್‌ – kannada" lang="kn" hreflang="kn" data-title="ಗ್ಲೈಕೋಪ್ರೋಟೀನ್‌" data-language-autonym="ಕನ್ನಡ" data-language-local-name="kannada" class="interlanguage-link-target"><span>ಕನ್ನಡ</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%8B%B9%EB%8B%A8%EB%B0%B1%EC%A7%88" title="당단백질 – coréen" lang="ko" hreflang="ko" data-title="당단백질" data-language-autonym="한국어" data-language-local-name="coréen" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%93%D0%BB%D0%B8%D0%BA%D0%BE%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%B4%D0%B4%D0%B5%D1%80" title="Гликопротеиддер – kirghize" lang="ky" hreflang="ky" data-title="Гликопротеиддер" data-language-autonym="Кыргызча" data-language-local-name="kirghize" class="interlanguage-link-target"><span>Кыргызча</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Glycoproteinum" title="Glycoproteinum – latin" lang="la" hreflang="la" data-title="Glycoproteinum" data-language-autonym="Latina" data-language-local-name="latin" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Glikoproteinai" title="Glikoproteinai – lituanien" lang="lt" hreflang="lt" data-title="Glikoproteinai" data-language-autonym="Lietuvių" data-language-local-name="lituanien" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Glikoprote%C4%ABns" title="Glikoproteīns – letton" lang="lv" hreflang="lv" data-title="Glikoproteīns" data-language-autonym="Latviešu" data-language-local-name="letton" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%93%D0%BB%D0%B8%D0%BA%D0%BE%D0%B1%D0%B5%D0%BB%D0%BA%D0%BE%D0%B2%D0%B8%D0%BD%D0%B0" title="Гликобелковина – macédonien" lang="mk" hreflang="mk" data-title="Гликобелковина" data-language-autonym="Македонски" data-language-local-name="macédonien" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Glikoprotein" title="Glikoprotein – malais" lang="ms" hreflang="ms" data-title="Glikoprotein" data-language-autonym="Bahasa Melayu" data-language-local-name="malais" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Glycoprote%C3%AFne" title="Glycoproteïne – néerlandais" lang="nl" hreflang="nl" data-title="Glycoproteïne" data-language-autonym="Nederlands" data-language-local-name="néerlandais" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Glykoprotein" title="Glykoprotein – norvégien nynorsk" lang="nn" hreflang="nn" data-title="Glykoprotein" data-language-autonym="Norsk nynorsk" data-language-local-name="norvégien nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Glykoprotein" title="Glykoprotein – norvégien bokmål" lang="nb" hreflang="nb" data-title="Glykoprotein" data-language-autonym="Norsk bokmål" data-language-local-name="norvégien bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Glicoprote%C3%AFna" title="Glicoproteïna – occitan" lang="oc" hreflang="oc" data-title="Glicoproteïna" data-language-autonym="Occitan" data-language-local-name="occitan" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Glikoproteiny" title="Glikoproteiny – polonais" lang="pl" hreflang="pl" data-title="Glikoproteiny" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Glicoprote%C3%ADna" title="Glicoproteína – portugais" lang="pt" hreflang="pt" data-title="Glicoproteína" data-language-autonym="Português" data-language-local-name="portugais" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Glicoprotein%C4%83" title="Glicoproteină – roumain" lang="ro" hreflang="ro" data-title="Glicoproteină" data-language-autonym="Română" data-language-local-name="roumain" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%BB%D0%B8%D0%BA%D0%BE%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D1%8B" title="Гликопротеины – russe" lang="ru" hreflang="ru" data-title="Гликопротеины" data-language-autonym="Русский" data-language-local-name="russe" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Glikoprotein" title="Glikoprotein – serbo-croate" lang="sh" hreflang="sh" data-title="Glikoprotein" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croate" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Glycoprotein" title="Glycoprotein – Simple English" lang="en-simple" hreflang="en-simple" data-title="Glycoprotein" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Glikoprotein" title="Glikoprotein – slovène" lang="sl" hreflang="sl" data-title="Glikoprotein" data-language-autonym="Slovenščina" data-language-local-name="slovène" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Glikoprotein" title="Glikoprotein – serbe" lang="sr" hreflang="sr" data-title="Glikoprotein" data-language-autonym="Српски / srpski" data-language-local-name="serbe" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Glykoprotein" title="Glykoprotein – suédois" lang="sv" hreflang="sv" data-title="Glykoprotein" data-language-autonym="Svenska" data-language-local-name="suédois" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%95%E0%AE%BF%E0%AE%B3%E0%AF%88%E0%AE%95%E0%AF%8D%E0%AE%95%E0%AF%8B%E0%AE%AA%E0%AF%81%E0%AE%B0%E0%AE%A4%E0%AE%AE%E0%AF%8D" title="கிளைக்கோபுரதம் – tamoul" lang="ta" hreflang="ta" data-title="கிளைக்கோபுரதம்" data-language-autonym="தமிழ்" data-language-local-name="tamoul" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-tg mw-list-item"><a href="https://tg.wikipedia.org/wiki/%D0%93%D0%BB%D0%B8%D0%BA%D0%BE%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD%D2%B3%D0%BE" title="Гликопротеинҳо – tadjik" lang="tg" hreflang="tg" data-title="Гликопротеинҳо" data-language-autonym="Тоҷикӣ" data-language-local-name="tadjik" class="interlanguage-link-target"><span>Тоҷикӣ</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%84%E0%B8%81%E0%B8%A5%E0%B9%82%E0%B8%84%E0%B9%82%E0%B8%9B%E0%B8%A3%E0%B8%95%E0%B8%B5%E0%B8%99" title="ไกลโคโปรตีน – thaï" lang="th" hreflang="th" data-title="ไกลโคโปรตีน" data-language-autonym="ไทย" data-language-local-name="thaï" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Glikoprotein" title="Glikoprotein – turc" lang="tr" hreflang="tr" data-title="Glikoprotein" data-language-autonym="Türkçe" data-language-local-name="turc" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%93%D0%BB%D1%96%D0%BA%D0%BE%D0%BF%D1%80%D0%BE%D1%82%D0%B5%D1%97%D0%BD%D0%B8" title="Глікопротеїни – ukrainien" lang="uk" hreflang="uk" data-title="Глікопротеїни" data-language-autonym="Українська" data-language-local-name="ukrainien" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Glikoproteidlar" title="Glikoproteidlar – ouzbek" lang="uz" hreflang="uz" data-title="Glikoproteidlar" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="ouzbek" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Glycoprotein" title="Glycoprotein – vietnamien" lang="vi" hreflang="vi" data-title="Glycoprotein" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamien" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E7%B3%96%E8%9B%8B%E7%99%BD" title="糖蛋白 – wu" lang="wuu" hreflang="wuu" data-title="糖蛋白" data-language-autonym="吴语" data-language-local-name="wu" class="interlanguage-link-target"><span>吴语</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E9%86%A3%E8%9B%8B%E7%99%BD" title="醣蛋白 – chinois" lang="zh" hreflang="zh" data-title="醣蛋白" data-language-autonym="中文" data-language-local-name="chinois" class="interlanguage-link-target"><span>中文</span></a></li><li class="interlanguage-link interwiki-zh-yue mw-list-item"><a href="https://zh-yue.wikipedia.org/wiki/%E9%86%A3%E8%9B%8B%E7%99%BD" title="醣蛋白 – cantonais" lang="yue" hreflang="yue" data-title="醣蛋白" data-language-autonym="粵語" data-language-local-name="cantonais" class="interlanguage-link-target"><span>粵語</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q187126#sitelinks-wikipedia" title="Modifier les liens interlangues" class="wbc-editpage">Modifier les liens</a></span></div> </div> </div> </div> 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href="https://www.wikidata.org/wiki/Special:EntityPage/Q187126" title="Lien vers l’élément dans le dépôt de données connecté [g]" accesskey="g"><span>Élément Wikidata</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Outils de la page"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Apparence"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Apparence</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">masquer</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Un article de Wikipédia, l'encyclopédie libre.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="fr" dir="ltr"><p>Une <b>glycoprotéine</b> est une <a href="/wiki/Prot%C3%A9ine" title="Protéine">protéine</a> portant un ou plusieurs groupements <a href="/wiki/Oligosaccharide" title="Oligosaccharide">oligosides</a>. C'est un <a href="/wiki/H%C3%A9t%C3%A9roside" title="Hétéroside">hétéroside</a> ou substance née de la condensation d'un sucre et d'une substance non glycidique, composé de plusieurs <a href="/wiki/Ose" title="Ose">oses</a> différents et dont le premier motif <a href="/wiki/Glucide" title="Glucide">glucidique</a> est fixé de façon <a href="/wiki/Liaison_covalente" title="Liaison covalente">covalente</a> à la chaine <a href="/wiki/Polypeptide" title="Polypeptide">polypeptidique</a>. </p><p>Une glycoprotéine est synthétisée par la <a href="/wiki/Glycosylation" title="Glycosylation">glycosylation</a> d’une <a href="/wiki/Prot%C3%A9ine" title="Protéine">protéine</a>, qui peut être de trois types (<a href="/wiki/N-glycosylation" title="N-glycosylation">N-glycosylation</a>, <a href="/wiki/C-glycosylation" title="C-glycosylation">C-glycosylation</a> et <a href="/wiki/O-glycosylation" title="O-glycosylation">O-glycosylation</a>) selon l’<a href="/wiki/Acide_amin%C3%A9" title="Acide aminé">acide aminé</a> utilisé, <a href="/wiki/Asparagine" title="Asparagine">asparagine</a> (NH2), <a href="/wiki/Tryptophane" title="Tryptophane">tryptophane</a> (en C2), <a href="/wiki/S%C3%A9rine" title="Sérine">sérine</a> ou <a href="/wiki/Thr%C3%A9onine" title="Thréonine">thréonine</a> (OH). Les <a href="/wiki/Glycophorine" title="Glycophorine">glycophorines</a> sont, parmi bien d'autres, un exemple de glycoprotéines. </p><p>Les glycoprotéines ne renferment pas d'<a href="/wiki/Acide_uronique" title="Acide uronique">acide uronique</a>, ni des <a href="/wiki/Ester" title="Ester">esters</a> <a href="/wiki/Sulfate" title="Sulfate">sulfates</a> dans leur structure. La fraction glucidique peut représenter 5 à 40 % de la <a href="/wiki/Mol%C3%A9cule" title="Molécule">molécule</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Exemples_de_glycoprotéines"><span id="Exemples_de_glycoprot.C3.A9ines"></span>Exemples de glycoprotéines</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=1" title="Modifier la section : Exemples de glycoprotéines" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=1" title="Modifier le code source de la section : Exemples de glycoprotéines"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Fibronectine">Fibronectine</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=2" title="Modifier la section : Fibronectine" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=2" title="Modifier le code source de la section : Fibronectine"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="bandeau-container bandeau-section metadata bandeau-niveau-information"><div class="bandeau-cell bandeau-icone-css loupe">Article détaillé : <a href="/wiki/Fibronectine" title="Fibronectine">Fibronectine</a>.</div></div> <p>Glycoprotéine composée de 2 sous-unités protéiques reliées par une paire de <a href="/wiki/Pont_disulfure" title="Pont disulfure">ponts disulfure</a> à leur extrémité C-terminale. Elle est par conséquent dimérique. </p><p>Elle possède différents motifs de liaison : </p> <ul><li>aux <a href="/wiki/Prot%C3%A9oglycane" title="Protéoglycane">protéoglycanes</a> ;</li> <li>aux <a href="/wiki/Int%C3%A9grine" title="Intégrine">intégrines</a> (via leur <a href="/wiki/S%C3%A9quence_RGD" title="Séquence RGD">séquence RGD</a>) ;</li> <li>au <a href="/wiki/Collag%C3%A8ne" title="Collagène">collagène</a>.</li></ul> <div class="mw-heading mw-heading3"><h3 id="Laminine">Laminine</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=3" title="Modifier la section : Laminine" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=3" title="Modifier le code source de la section : Laminine"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="bandeau-container bandeau-section metadata bandeau-niveau-information"><div class="bandeau-cell bandeau-icone-css loupe">Article détaillé : <a href="/wiki/Laminine" title="Laminine">laminine</a>.</div></div> <p>Glycoprotéine de la <a href="/wiki/Membrane_basale" title="Membrane basale">membrane basale</a>, molécule flexible de 3 chaînes comportant plusieurs domaines : </p> <ul><li>2 chaînes bêta : <ul><li>bêta 1 : site de fixation des <a href="/wiki/Cellule_(biologie)" title="Cellule (biologie)">cellules</a> et du <a href="/wiki/Collag%C3%A8ne" title="Collagène">collagène</a> IV (voir <abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <a href="https://en.wikipedia.org/wiki/Type_IV_collagen" class="extiw" title="en:Type IV collagen">Type IV collagen</a>),</li> <li>bêta 2 : site de fixation du collagène IV ;</li></ul></li> <li>1 chaîne alpha qui fixe les protéoglycanes, les stéroïdes et des récepteurs de la <a href="/wiki/Membrane_plasmique" title="Membrane plasmique">membrane plasmique</a> comme les intégrines et les dystroglycanes.</li></ul> <p>Elle constitue un support de liaison de plusieurs composants de la matrice, les organise en réseau et régule l'adhérence cellule-matrice. </p> <div class="mw-heading mw-heading3"><h3 id="Anticorps">Anticorps</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=4" title="Modifier la section : Anticorps" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=4" title="Modifier le code source de la section : Anticorps"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="bandeau-container bandeau-section metadata bandeau-niveau-information"><div class="bandeau-cell bandeau-icone-css loupe">Article détaillé : <a href="/wiki/Anticorps" title="Anticorps">Anticorps</a>.</div></div> <p>Glycoprotéine complexe utilisée par le <a href="/wiki/Syst%C3%A8me_immunitaire_adaptatif" title="Système immunitaire adaptatif">système immunitaire adaptatif</a> pour détecter et neutraliser les agents pathogènes et sécrétés par les <a href="/wiki/Plasmocyte" title="Plasmocyte">plasmocytes</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Implication_dans_des_processus_biologiques[1]"><span id="Implication_dans_des_processus_biologiques.5B1.5D"></span>Implication dans des processus biologiques<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup></h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=5" title="Modifier la section : Implication dans des processus biologiques[1]" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=5" title="Modifier le code source de la section : Implication dans des processus biologiques[1]"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Inflammation">Inflammation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=6" title="Modifier la section : Inflammation" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=6" title="Modifier le code source de la section : Inflammation"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading4"><h4 id="Sélectine_et_Intégrine"><span id="S.C3.A9lectine_et_Int.C3.A9grine"></span><a href="/wiki/S%C3%A9lectine" title="Sélectine">Sélectine</a> et <a href="/wiki/Int%C3%A9grine" title="Intégrine">Intégrine</a></h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=7" title="Modifier la section : Sélectine et Intégrine" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=7" title="Modifier le code source de la section : Sélectine et Intégrine"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Les sélectines sont des glycoprotéines qui se trouvent dans l’espace transmembranaire des leucocytes et des cellules endothéliales. Leur interaction retient les leucocytes sur un court temps pour permettre l’action des intégrines par la suite. Les intégrines, également localisées sur les leucocytes et les cellules endothéliales, permettent l’<a href="/wiki/Adh%C3%A9sion_cellulaire" title="Adhésion cellulaire">adhésion cellulaire</a> et l’enclenchement de la <a href="/wiki/Diap%C3%A9d%C3%A8se" title="Diapédèse">diapédèse</a>. La diapédèse est l’événement qui permet le déplacement des leucocytes du sang jusqu’au site de l’inflammation. </p> <div class="mw-heading mw-heading3"><h3 id="Fécondation"><span id="F.C3.A9condation"></span>Fécondation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=8" title="Modifier la section : Fécondation" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=8" title="Modifier le code source de la section : Fécondation"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Les glycoprotéines sont importantes dans la fécondation, car elles permettent la liaison du spermatozoïde à l’<a href="/wiki/Ovocyte" title="Ovocyte">ovocyte</a>. </p> <div class="mw-heading mw-heading4"><h4 id="ZP3"><a href="/wiki/ZP3" title="ZP3">ZP3</a></h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=9" title="Modifier la section : ZP3" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=9" title="Modifier le code source de la section : ZP3"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La glycoprotéine ZP3, située sur la zone pellucide de l’ovocyte, est un récepteur qui lie le spermatozoïde. Cette interaction enclenche la réaction acrosomale et la libération d’enzymes qui permettent au spermatozoïde de traverser la <a href="/wiki/Zone_pellucide" title="Zone pellucide">zone pellucide</a>. </p> <div class="mw-heading mw-heading4"><h4 id="PH-30">PH-30</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=10" title="Modifier la section : PH-30" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=10" title="Modifier le code source de la section : PH-30"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PH-30 est une protéine glycosylée, localisée sur la membrane plasmique de l’ovocyte, qui lie également le spermatozoïde. Leur interaction amène à l’introduction du spermatozoïde à l’intérieur de l’ovocyte. </p><p>Sans ces deux glycoprotéines, le spermatozoïde ne peut pas fertiliser l’ovocyte. </p> <div class="mw-heading mw-heading2"><h2 id="Implication_dans_des_maladies[2]"><span id="Implication_dans_des_maladies.5B2.5D"></span>Implication dans des maladies<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup></h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=11" title="Modifier la section : Implication dans des maladies[2]" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=11" title="Modifier le code source de la section : Implication dans des maladies[2]"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Il existe plusieurs maladies qui sont causées par des défauts dans la production des glycoprotéines. </p> <div class="mw-heading mw-heading3"><h3 id="Cancer">Cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=12" title="Modifier la section : Cancer" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=12" title="Modifier le code source de la section : Cancer"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Il existe des cellules cancéreuses qui possèdent plusieurs types de glycoprotéines sur leur membrane. Il est connu que certaines de ces glycoprotéines sont directement impliquées dans la production de métastase. </p> <div class="mw-heading mw-heading3"><h3 id="Défaut_d’adhérence_des_leucocytes_de_type_II"><span id="D.C3.A9faut_d.E2.80.99adh.C3.A9rence_des_leucocytes_de_type_II"></span>Défaut d’adhérence des leucocytes de type II</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=13" title="Modifier la section : Défaut d’adhérence des leucocytes de type II" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=13" title="Modifier le code source de la section : Défaut d’adhérence des leucocytes de type II"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Cette maladie est représentée par l’absence de glycoprotéines fucosylés, qui sont des protéines ayant subi une fucosylation (type de glycosylation). Les sélectines, qui lient normalement ces glycoprotéines, ne peuvent pas interagir avec leur ligand. Elles ne peuvent donc pas permettre le déplacement des leucocytes à l’extérieur des vaisseaux sanguins, puis au site de l’inflammation. </p> <div class="mw-heading mw-heading3"><h3 id="Hémoglobinurie_paroxystique_nocturne_(PNH)"><span id="H.C3.A9moglobinurie_paroxystique_nocturne_.28PNH.29"></span>Hémoglobinurie paroxystique nocturne (PNH)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=14" title="Modifier la section : Hémoglobinurie paroxystique nocturne (PNH)" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=14" title="Modifier le code source de la section : Hémoglobinurie paroxystique nocturne (PNH)"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Dans cette maladie, il y a deux glycoprotéines mutées qui sont impliquées; le DAF et le CD59. Ces deux protéines, en temps normal, ont une action inhibitrice sur le système du complément. Ainsi, sans l’action des deux glycoprotéines, le système du complément peut agir sur les globules rouges et causer leur hémolyse. </p> <div class="mw-heading mw-heading3"><h3 id="Arthrite_rhumatoïde"><span id="Arthrite_rhumato.C3.AFde"></span>Arthrite rhumatoïde</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=15" title="Modifier la section : Arthrite rhumatoïde" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=15" title="Modifier le code source de la section : Arthrite rhumatoïde"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La maladie arthrite rhumatoïde est représentée par de l’inflammation chronique au niveau des articulations. Cette inflammation est causée par la liaison anormale et abondante de la protéine de liaison du mannose (MBP) au <a href="/wiki/Immunoglobuline_G" title="Immunoglobuline G">immunoglobuline G</a> (IgG). Dans ce cas-ci, le processus de glycosylation des immunoglobuline G (IgG) est anormal, ce qui provoque leur liaison aux MBP. </p> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=16" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=16" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references-small decimal" style=""><div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink noprint"><a href="#cite_ref-1">↑</a> </span><span class="reference-text"><span class="ouvrage" id="Rodwell,_D.A._Bender,_K.M._Botham,_P.J._Kennelly,_P.A._Weil"><span class="ouvrage" id="V.W._Rodwell,_D.A._Bender,_K.M._Botham,_P.J._Kennelly,_P.A._Weil">V.W. Rodwell, D.A. Bender, K.M. Botham, P.J. Kennelly, P.A. Weil, <cite class="italique">Biochimie de Harper</cite>, Boeck Supérieur, 817 <abbr class="abbr" title="pages">p.</abbr>, <abbr class="abbr" title="page">p.</abbr> 579<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Biochimie+de+Harper&rft.pub=Boeck+Sup%C3%A9rieur&rft.au=V.W.+Rodwell%2C+D.A.+Bender%2C+K.M.+Botham%2C+P.J.+Kennelly%2C+P.A.+Weil&rft.pages=579&rft.tpages=817&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AGlycoprot%C3%A9ine"></span></span></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink noprint"><a href="#cite_ref-2">↑</a> </span><span class="reference-text"><span class="ouvrage" id="Rodwell,_D.A._Bender,_K.M._Botham,_P.J._Kennelly,_P.A._Weil"><span class="ouvrage" id="V.W._Rodwell,_D.A._Bender,_K.M._Botham,_P.J._Kennelly,_P.A._Weil">V.W. Rodwell, D.A. Bender, K.M. Botham, P.J. Kennelly, P.A. Weil, <cite class="italique">Biochimie de Harper</cite>, Boeck Supérieur, 817 <abbr class="abbr" title="pages">p.</abbr>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">580-581</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Biochimie+de+Harper&rft.pub=Boeck+Sup%C3%A9rieur&rft.au=V.W.+Rodwell%2C+D.A.+Bender%2C+K.M.+Botham%2C+P.J.+Kennelly%2C+P.A.+Weil&rft.pages=580-581&rft.tpages=817&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AGlycoprot%C3%A9ine"></span></span></span></span> </li> </ol></div> </div> <div class="mw-heading mw-heading2"><h2 id="Voir_aussi">Voir aussi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=17" title="Modifier la section : Voir aussi" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=17" title="Modifier le code source de la section : Voir aussi"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Articles_connexes">Articles connexes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=18" title="Modifier la section : Articles connexes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=18" title="Modifier le code source de la section : Articles connexes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/ZP1" title="ZP1">ZP1</a></li> <li><a href="/wiki/Carence_alimentaire_en_s%C3%A9l%C3%A9nium" title="Carence alimentaire en sélénium">Carence alimentaire en sélénium</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Liens_externes">Liens externes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glycoprot%C3%A9ine&veaction=edit&section=19" title="Modifier la section : Liens externes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Glycoprot%C3%A9ine&action=edit&section=19" title="Modifier le code source de la section : Liens externes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/10207176">C-mannosylation de protéine, interleukine 12</a></li> <li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC25252/">C-mannosylation de protéine, ribonucléase 2</a></li> <li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/10551839">C-mannosylation de protéine, fractions du complément, C6, C7, C8, C9</a></li></ul> <div class="navbox-container" style="clear:both;"> <table class="navbox collapsible noprint autocollapse" style=""> <tbody><tr><th class="navbox-title" colspan="2" style=""><div style="float:left; width:6em; text-align:left"><div class="noprint plainlinks nowrap tnavbar" style="padding:0; font-size:xx-small; color:var(--color-emphasized, #000000);"><a href="/wiki/Mod%C3%A8le:Palette_Prot%C3%A9ines" title="Modèle:Palette Protéines"><abbr class="abbr" title="Voir ce modèle.">v</abbr></a> · <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Mod%C3%A8le:Palette_Prot%C3%A9ines&action=edit"><abbr class="abbr" title="Modifier ce modèle. Merci de prévisualiser avant de sauvegarder.">m</abbr></a></div></div><div style="font-size:110%"><a href="/wiki/Prot%C3%A9ine" title="Protéine">Protéines</a></div></th> </tr> <tr> <th class="navbox-group" style="width:160px">Général</th> <td class="navbox-list" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Biosynth%C3%A8se_des_prot%C3%A9ines" title="Biosynthèse des protéines">Biosynthèse des protéines</a></li> <li><a href="/wiki/Modification_post-traductionnelle" title="Modification post-traductionnelle">Modification des protéines</a></li> <li><a href="/wiki/Prot%C3%A9asome" title="Protéasome">Protéasome</a></li> <li><a href="/wiki/Prot%C3%A9ome" title="Protéome">Protéome</a></li> <li><a href="/wiki/Prot%C3%A9ine_membranaire" title="Protéine membranaire">Protéine membranaire</a></li> <li><a href="/wiki/Proteopedia" title="Proteopedia">Proteopedia</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="width:160px"><a href="/wiki/Structure_des_prot%C3%A9ines" title="Structure des protéines">Structure</a></th> <td class="navbox-list navbox-even" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Structure_primaire" title="Structure primaire">Structure primaire</a></li> <li><a href="/wiki/Structure_secondaire" title="Structure secondaire">Structure secondaire</a></li> <li><a href="/wiki/Structure_tertiaire" title="Structure tertiaire">Structure tertiaire</a></li> <li><a href="/wiki/Structure_quaternaire" title="Structure quaternaire">Structure quaternaire</a></li> <li><a href="/wiki/Pr%C3%A9diction_de_la_structure_des_prot%C3%A9ines" title="Prédiction de la structure des protéines">Prédiction</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="width:160px">Classification</th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="width:80px">Forme</th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Prot%C3%A9ine_fibreuse" title="Protéine fibreuse">Protéine fibreuse</a></li> <li><a href="/wiki/Prot%C3%A9ine_globulaire" title="Protéine globulaire">Protéine globulaire</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="width:80px">Composition</th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Holoprot%C3%A9ine" title="Holoprotéine">Holoprotéine</a></li> <li><a href="/wiki/H%C3%A9t%C3%A9roprot%C3%A9ine" title="Hétéroprotéine">Hétéroprotéine</a> <ul><li><a href="/wiki/Nucl%C3%A9oprot%C3%A9ine" title="Nucléoprotéine">Nucléoprotéine</a></li> <li><a class="mw-selflink selflink">Glycoprotéine</a></li> <li><a href="/wiki/Lipoprot%C3%A9ine" title="Lipoprotéine">Lipoprotéine</a></li> <li><a href="/wiki/Phosphoprot%C3%A9ine" title="Phosphoprotéine">Phosphoprotéine</a></li> <li><a href="/wiki/M%C3%A9talloprot%C3%A9ine" title="Métalloprotéine">Métalloprotéine</a></li> <li><a href="/wiki/Chromoprot%C3%A9ine" title="Chromoprotéine">Chromoprotéine</a> <ul><li><a href="/wiki/Flavoprot%C3%A9ine" title="Flavoprotéine">Flavoprotéine</a></li> <li><a href="/wiki/H%C3%A9moprot%C3%A9ine" title="Hémoprotéine">Hémoprotéine</a></li></ul></li></ul></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="width:160px">Dosage colorimétrique</th> <td class="navbox-list navbox-even" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/M%C3%A9thode_BCA" title="Méthode BCA">Méthode BCA</a></li> <li><a href="/wiki/M%C3%A9thode_de_Bradford" title="Méthode de Bradford">Méthode de Bradford</a></li> <li><a href="/wiki/M%C3%A9thode_de_Lowry" title="Méthode de Lowry">Méthode de Lowry</a></li> <li><a href="/wiki/M%C3%A9thode_du_biuret" title="Méthode du biuret">Méthode du biuret</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="width:160px">Méthodes d'investigation des interactions</th> <td class="navbox-list" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Interaction_prot%C3%A9ine-prot%C3%A9ine" title="Interaction protéine-protéine">Protéine-protéine</a> <ul><li><a href="/wiki/Double_hybride" title="Double hybride">Double hybride</a></li> <li><a href="/wiki/PCA_protein_complementation_assay" title="PCA protein complementation assay">PCA protein complementation assay</a></li> <li><a href="/wiki/Proximity_ligation_assay" title="Proximity ligation assay">Proximity ligation assay</a></li></ul></li> <li>Protéine-ADN <ul><li><a href="/wiki/ChIP-on-Chip" title="ChIP-on-Chip">Chip on chip</a></li> <li><a href="/wiki/Chip-Seq" class="mw-redirect" title="Chip-Seq">Chip-Seq</a></li></ul></li></ul> </div></td> </tr> </tbody></table> </div> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer" typeof="mw:File"><a href="/wiki/Portail:Biochimie" 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