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class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="André Ricardo Ribas Freitas" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/1832802/852614/1062041/s200_andr_ricardo.ribas_freitas.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">André Ricardo Ribas Freitas</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://slmandic.academia.edu/">Centro de Pesquisas em Odontologia Sao Leopoldo Mandic</a>, <a class="u-tcGrayDarker" href="https://slmandic.academia.edu/Departments/Epidemiology/Documents">Epidemiology</a>, <span class="u-tcGrayDarker">Faculty Member</span></div><div><a class="u-tcGrayDarker" href="https://unicamp.academia.edu/">Universidade Estadual 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role="tab">More  <i class="fa fa-chevron-down"></i></a><ul class="js-profile-documents-more-dropdown dropdown-menu dropdown-menu-right profile-documents-more-dropdown" role="menu"><li role="presentation"><a data-click-track="profile-works-tab" data-section-name="Teaching-Documents" data-toggle="tab" href="#teachingdocuments" role="tab" style="border: none;"><span>3</span> Teaching Documents</a></li><li role="presentation"><a data-click-track="profile-works-tab" data-section-name="Talks" data-toggle="tab" href="#talks" role="tab" style="border: none;"><span>2</span> Talks</a></li><li role="presentation"><a data-click-track="profile-works-tab" data-section-name="Videos" data-toggle="tab" href="#videos" role="tab" style="border: none;"><span>3</span> Videos</a></li><li role="presentation"><a data-click-track="profile-works-tab" data-section-name="Drafts" data-toggle="tab" href="#drafts" role="tab" style="border: none;"><span>2</span> Drafts</a></li></ul></li></ul></div><div class="divider ds-divider-16" style="margin: 0px;"></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by André Ricardo Ribas Freitas</h3></div><div class="js-work-strip profile--work_container" data-work-id="42963884"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/42963884/Covid_19_em_contexto_compara%C3%A7%C3%A3o_com_a_mortalidade_mensal_por_causas_respirat%C3%B3rias_nos_estados_brasileiros"><img alt="Research paper thumbnail of Covid-19 em contexto: comparação com a mortalidade mensal por causas respiratórias nos estados brasileiros" class="work-thumbnail" src="https://attachments.academia-assets.com/63220982/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/42963884/Covid_19_em_contexto_compara%C3%A7%C3%A3o_com_a_mortalidade_mensal_por_causas_respirat%C3%B3rias_nos_estados_brasileiros">Covid-19 em contexto: comparação com a mortalidade mensal por causas respiratórias nos estados brasileiros</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ufpa.academia.edu/COVID19">COVID 19</a></span></div><div class="wp-workCard_item"><span>InterAmerican Journal of Medicine and Health</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">RESUMO Decisões críticas no combate à pandemia causada pelo SARS-CoV-2 têm sido realizadas freque...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">RESUMO Decisões críticas no combate à pandemia causada pelo SARS-CoV-2 têm sido realizadas frequentemente com dados e informações ainda incompletas. Enquanto os órgãos pertinentes não solucionam os gargalos no fluxo de informações de vital importância, epidemiólogos e outros pesquisadores devem produzir subsídios técnicos para o enfrentamento da crise contornando essas limitações. No presente estudo, focado no Brasil, comparamos os óbitos pelo SARS-CoV-2, disponibilizados diariamente, com os dados de óbitos por doenças respiratórias e outras doenças nos anos de 2014 a 2018 (os últimos cinco anos completos para os quais os dados estão disponíveis). Adicionalmente, extraímos os sinais temporais anuais dos óbitos por doenças respiratórias para que o período típico de pico na mortalidade por essas do enças possa ser considerado em cada estado Brasileiro. A porcentagem de óbitos pelo SARS-CoV-2 até o dia 15 de abril equivale a 24% da mortalidade esperada por causas respiratórias no mesmo período, com base em anos anteriores, com grande variação entre os estados (desde o Amazonas, 151%, até o Tocantins, com 3%). Estamos na época típica de pico de mortalidade associada a doenças respiratórias em grande parte do Norte e Nordeste (com exceção de Roraima). Nas regiões Sudeste e Sul, esse pico é mais tardio (junho-agosto). A evolução da pandemia em cada estado dependerá, no entanto, de vários outros fatores, como o comportamento do patógeno-ainda não conhecido suficientemente. Ressaltamos a necessidade de ações para aumento da agilidade na disponibilização dos dados atuais de mortalidade (por diversas causas), para que equipes de pesquisa com diferentes abordagens analíticas possam se somar no combate a este desafio sanitário global.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="52b2349efcfdd4cf1c5348ce7fd83012" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63220982,"asset_id":42963884,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63220982/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="42963884"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="42963884"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42963884; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42963884]").text(description); $(".js-view-count[data-work-id=42963884]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42963884; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='42963884']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "52b2349efcfdd4cf1c5348ce7fd83012" } } $('.js-work-strip[data-work-id=42963884]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":42963884,"title":"Covid-19 em contexto: comparação com a mortalidade mensal por causas respiratórias nos estados brasileiros","internal_url":"https://www.academia.edu/42963884/Covid_19_em_contexto_compara%C3%A7%C3%A3o_com_a_mortalidade_mensal_por_causas_respirat%C3%B3rias_nos_estados_brasileiros","owner_id":157086094,"coauthors_can_edit":true,"owner":{"id":157086094,"first_name":"COVID","middle_initials":null,"last_name":"19","page_name":"COVID19","domain_name":"ufpa","created_at":"2020-05-06T12:45:37.775-07:00","display_name":"COVID 19","url":"https://ufpa.academia.edu/COVID19"},"attachments":[{"id":63220982,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63220982/thumbnails/1.jpg","file_name":"93-Article_Text-450-1-10-20200506_120200506-82766-xjk814.pdf","download_url":"https://www.academia.edu/attachments/63220982/download_file","bulk_download_file_name":"Covid_19_em_contexto_comparacao_com_a_mo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63220982/93-Article_Text-450-1-10-20200506_120200506-82766-xjk814-libre.pdf?1588799376=\u0026response-content-disposition=attachment%3B+filename%3DCovid_19_em_contexto_comparacao_com_a_mo.pdf\u0026Expires=1740174660\u0026Signature=goH~pADmuuJ~fxLDdNZ9H0xxNyVy1hW1iTTSPc39rPRijU0NaPT2mTffd~fG~ZW7wdDyQPlCfLAWNG-56h~DYmICGK8Z3aOLWv2agu~PpkWhZ9Gi4zYoy6bP7Fg1vtMIhsGol8AavqjxnJv4V1KD~0GFfW5qUNBfMCOcwgF-a2yHfbSJ~nibYj4tDHtcC-uIKLZZFDAB1jCBUY7TjjU-2RXLFlcmV2xNuW6hLN2~CKYcIntMWudqKyMrIIptZ-CjwYuo9zSt7lR4zlndDO7yeBiDZQqQQ628SuvufpTwo9sNs8KE8veOPfOhPg21b9YamTEw1i0WUocsXl473ByKPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43152542"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43152542/Respiratory_syncytial_virus_causes_more_hospitalizations_and_deaths_in_equatorial_Brazil_than_influenza_including_during_the_2009_pandemic_"><img alt="Research paper thumbnail of Respiratory syncytial virus causes more hospitalizations and deaths in equatorial Brazil than influenza (including during the 2009 pandemic)" class="work-thumbnail" src="https://attachments.academia-assets.com/63413830/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43152542/Respiratory_syncytial_virus_causes_more_hospitalizations_and_deaths_in_equatorial_Brazil_than_influenza_including_during_the_2009_pandemic_">Respiratory syncytial virus causes more hospitalizations and deaths in equatorial Brazil than influenza (including during the 2009 pandemic)</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite numerous studies evaluating influenza and Respiratory Syncytial Virus (RSV), there is sti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite numerous studies evaluating influenza and Respiratory Syncytial Virus (RSV), there is still a lack of knowledge about them, especially in tropical countries. We compared the relative importance of respiratory viruses by examining their spatiotemporal patterns, age-specific hospitalization data and mortality data for 2007-2012 obtained from official sources. The data were aggregated into “respiratory infection seasonal zones” formed combining states that had similar seasonal patterns of pneumonia and influenza (P&I). Equatorial-North where P&I peaks in the middle of the year, Equatorial-South where P&I peaks in the first semester and coincides with the rainy-season, Subtropical where P&I peaks are clearly concentrated in the winter season, and Tropical Midwest and South-East where P&I peaks are a transition between the South-Equatorial and the Sub-tropical. Our analyses indicate that RSV has higher impact than influenza in equatorial region of Brazil, which was particularly evident during the circulation of the 2009pdm strain, and suggests that seasonal influenza may have a lower impact in Equatorial Brazil (and perhaps in other tropical regions of the world) than previously considered. Accordingly, we suggest that the broad assumption that influenza is the main cause of viral respiratory hospitalizations and death in equatorial regions be questioned with greater emphasis in future studies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16256c50a93dd70e6425875efa1f926c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63413830,"asset_id":43152542,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63413830/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43152542"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43152542"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43152542; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43152542]").text(description); $(".js-view-count[data-work-id=43152542]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43152542; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43152542']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "16256c50a93dd70e6425875efa1f926c" } } $('.js-work-strip[data-work-id=43152542]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43152542,"title":"Respiratory syncytial virus causes more hospitalizations and deaths in equatorial Brazil than influenza (including during the 2009 pandemic)","internal_url":"https://www.academia.edu/43152542/Respiratory_syncytial_virus_causes_more_hospitalizations_and_deaths_in_equatorial_Brazil_than_influenza_including_during_the_2009_pandemic_","owner_id":1832802,"coauthors_can_edit":true,"owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas Freitas","url":"https://slmandic.academia.edu/AndreRicardoRibasFreitas"},"attachments":[{"id":63413830,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63413830/thumbnails/1.jpg","file_name":"0001-3765-aabc-92-01-e2018058420200524-56530-1pt42f8.pdf","download_url":"https://www.academia.edu/attachments/63413830/download_file","bulk_download_file_name":"Respiratory_syncytial_virus_causes_more.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63413830/0001-3765-aabc-92-01-e2018058420200524-56530-1pt42f8-libre.pdf?1590359323=\u0026response-content-disposition=attachment%3B+filename%3DRespiratory_syncytial_virus_causes_more.pdf\u0026Expires=1740341698\u0026Signature=hGljfpEFkveMfX0ZBmpOhjBnM9gNKP55n8o-7~uEsi4jL37ggXH0MLOYN8KrvaKmDbJxNE~8MZgfKLGMiAaf-BtQ7LQQpUyopE2xeLqGs7QnywKq~O9zjMCTsrbFudXq8o6Y~bfTSxJi5eXLWiwN64LzUSi2mlYkwA6zsDi2NAa-rRSCIf7rtTzZXW847~9OUVetXUpRYFCZ5Zx2YEdlMfrnt40MLj1PSa1~oUToH9roKUCUv6vGs4y9hQTgb~wuQCGAXF5~CkLGSTHHMIIOuZHAxwg7Di3XVs11Q6cFZkXuk1P~GA86n84DqoefqPWlxgnFc6L~j4dUPULAD0TYpA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43152510"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43152510/Dentistry_vs_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_How_to_face_this_enemy"><img alt="Research paper thumbnail of Dentistry vs Severe Acute Respiratory Syndrome Coronavirus 2: How to face this enemy" class="work-thumbnail" src="https://attachments.academia-assets.com/63413794/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43152510/Dentistry_vs_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_How_to_face_this_enemy">Dentistry vs Severe Acute Respiratory Syndrome Coronavirus 2: How to face this enemy</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/MarceloNapimoga">Marcelo Napimoga</a></span></div><div class="wp-workCard_item"><span>RGO, Rev Gaúch Odontol.</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Since the beginning of the SARS-CoV-2 pandemic, numerous restrictive measures have been taken by ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Since the beginning of the SARS-CoV-2 pandemic, numerous restrictive measures have been taken by the governments of different countries. Recently, due to the high possibility of transmission in dental offices, there was a recommendation by the American, European and Brazilian governments to request the closing of the offices. In this commentary, we will give an overview of the reasons and perspectives of this scenario.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7dba1dee66b47c14716caebee5dc651c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63413794,"asset_id":43152510,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63413794/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43152510"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43152510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43152510; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37185265"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37185265/Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic_2014"><img alt="Research paper thumbnail of Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014" class="work-thumbnail" src="https://attachments.academia-assets.com/63372102/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37185265/Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic_2014">Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RobertPaulinoRamirez">Robert Paulino-Ramirez</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MariaRitaDonalisio">Maria Rita Donalisio</a></span></div><div class="wp-workCard_item"><span>Transactions of The Royal Society of Tropical Medicine and Hygiene</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 09...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic. Methods: Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic. Results: The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (>99% confidence interval) among individuals <5 y and >40 y of age. The mortality rates were higher among the elderly. The death excess was 2853. Correcting for the estimated underreporting, there were 4952 deaths during the chikungunya epidemic (49.8 deaths/100 000 population). Conclusion: This study suggests that chikungunya is an important cause of death (underlying or contributing). It is urgent to review clinical protocols and investigate the causes associated with deaths during chikungunya epidemics.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f0fe3c46beddfa2885e974dd9fb5fd2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63372102,"asset_id":37185265,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63372102/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37185265"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37185265"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37185265; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37185265]").text(description); $(".js-view-count[data-work-id=37185265]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37185265; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37185265']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f0fe3c46beddfa2885e974dd9fb5fd2" } } $('.js-work-strip[data-work-id=37185265]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37185265,"title":"Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014","translated_title":"","metadata":{"abstract":"Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic. Methods: Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic. Results: The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (\u003e99% confidence interval) among individuals \u003c5 y and \u003e40 y of age. The mortality rates were higher among the elderly. The death excess was 2853. Correcting for the estimated underreporting, there were 4952 deaths during the chikungunya epidemic (49.8 deaths/100 000 population). Conclusion: This study suggests that chikungunya is an important cause of death (underlying or contributing). It is urgent to review clinical protocols and investigate the causes associated with deaths during chikungunya epidemics.","ai_title_tag":"Excess Deaths in 2014 Chikungunya Epidemic","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Transactions of The Royal Society of Tropical Medicine and Hygiene"},"translated_abstract":"Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic. Methods: Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic. Results: The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (\u003e99% confidence interval) among individuals \u003c5 y and \u003e40 y of age. The mortality rates were higher among the elderly. The death excess was 2853. Correcting for the estimated underreporting, there were 4952 deaths during the chikungunya epidemic (49.8 deaths/100 000 population). Conclusion: This study suggests that chikungunya is an important cause of death (underlying or contributing). It is urgent to review clinical protocols and investigate the causes associated with deaths during chikungunya epidemics.","internal_url":"https://www.academia.edu/37185265/Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic_2014","translated_internal_url":"","created_at":"2018-08-05T19:27:34.712-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":1832802,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":31770861,"work_id":37185265,"tagging_user_id":1832802,"tagged_user_id":302555506,"co_author_invite_id":182404,"email":"p***n@uv.es","display_order":0,"name":"Pedro Alarcón-Elbal","title":"Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014"},{"id":31770862,"work_id":37185265,"tagging_user_id":1832802,"tagged_user_id":88554679,"co_author_invite_id":6731437,"email":"r***1@unibe.edu.do","display_order":4194304,"name":"Robert Paulino-Ramirez","title":"Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014"},{"id":31770863,"work_id":37185265,"tagging_user_id":1832802,"tagged_user_id":42712700,"co_author_invite_id":null,"email":"r***o@gmail.com","display_order":6291456,"name":"Maria Rita Donalisio","title":"Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014"}],"downloadable_attachments":[{"id":63372102,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63372102/thumbnails/1.jpg","file_name":"Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic__2014_10.1093_trstmh_try072.pdf","download_url":"https://www.academia.edu/attachments/63372102/download_file","bulk_download_file_name":"Excess_mortality_profile_during_the_Asia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63372102/Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic__2014_10.1093_trstmh_try072-libre.pdf?1589976999=\u0026response-content-disposition=attachment%3B+filename%3DExcess_mortality_profile_during_the_Asia.pdf\u0026Expires=1738716977\u0026Signature=AMdjFI2ZBiEW9k6O6RjYtbRKcdRc2~i0qXVDcfN-YfFqjl~eBNv2MdN9sJB17bttNVgyq4PLxthkqsesEy2eXa66XRpZIUbgZqshKPQYvs8h46hZJ2LOj8ce-g7gO~o5QhZ-HnmdBm-Kf3gZz4hzLsjutvml9ijXMdH3cUrkJwotSxEKhyPAm8xZDTub6qOBHIqbZ6vYzpQ2bWmttZ70w4ik7yxYCB-5NkZ4xE9QhrA~VQrf8O3LwHz8Zj1wlvkSgfgn194A2MgoS097DJVnyK3jJZCmP5MQcK6LsJ3NZvNpaIjp-oRrl9AJBAqjHdZAGPeeWARgJhKCNWvmRXnxqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic_2014","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic. Methods: Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic. Results: The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (\u003e99% confidence interval) among individuals \u003c5 y and \u003e40 y of age. The mortality rates were higher among the elderly. The death excess was 2853. Correcting for the estimated underreporting, there were 4952 deaths during the chikungunya epidemic (49.8 deaths/100 000 population). Conclusion: This study suggests that chikungunya is an important cause of death (underlying or contributing). It is urgent to review clinical protocols and investigate the causes associated with deaths during chikungunya epidemics.","owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas 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and Hemorrhagic Fevers","url":"https://www.academia.edu/Documents/in/Arboviruses_and_Hemorrhagic_Fevers"},{"id":1308498,"name":"Chikungunya Virus and Other Arboviruses","url":"https://www.academia.edu/Documents/in/Chikungunya_Virus_and_Other_Arboviruses"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="35268161"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/35268161/Excess_Mortality_Related_to_Chikungunya_Epidemics_in_the_Context_of_Co_circulation_of_Other_Arboviruses_in_Brazil"><img alt="Research paper thumbnail of Excess Mortality Related to Chikungunya Epidemics in the Context of Co-circulation of Other Arboviruses in Brazil" class="work-thumbnail" src="https://attachments.academia-assets.com/55128782/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/35268161/Excess_Mortality_Related_to_Chikungunya_Epidemics_in_the_Context_of_Co_circulation_of_Other_Arboviruses_in_Brazil">Excess Mortality Related to Chikungunya Epidemics in the Context of Co-circulation of Other Arboviruses in Brazil</a></div><div class="wp-workCard_item"><span>PLoS Currents</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: Chikungunya is an emerging arbovirus that reached the Western Hemisphere at the end...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: Chikungunya is an emerging arbovirus that reached the Western Hemisphere at the end of 2013. Studies in the Indian Ocean and India suggest that passive surveillance systems cannot recognize many of deaths associated with chikungunya, which can be inferred by an increase in the overall mortality observed during chikungunya epidemics.<br /><br />Objective: We assess the mortality associated with chikungunya epidemics in the most affected states in Brazil, from 2015 and 2016.<br /><br />Methods: We studied the monthly mortality by age group, comparing a period without epidemics to a chikungunya epidemic period, which we defined arbitrarily as consecutive months with incidences of more than 50 cases/100,000 persons.<br /><br />Results: We obtained official data from the National System of Reported Diseases (SINAN) and the Mortality Information System (SIM), both maintained by the Ministry of Health. We identified a significant increase in the all-cause mortality rate during chikungunya epidemics, while there was no similar mortality in the previous years, even during dengue epidemics. We estimated an excess of 4,505 deaths in Pernambuco during the chikungunya epidemics (47.9 per 100,000 persons).The most affected age groups were the elderly and those under 1 year of age, and the same pattern occurred in all the states.<br /><br />Discussion: Further studies at other sites are needed to confirm the association between increased mortality and chikungunya epidemics indifferent age groups. If these findings are confirmed, it will be necessary to revise the guidelines to recognize the actual mortality associated with chikungunya and to improve therapeutic approaches and protective measures in the most vulnerable groups.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5077abb0fa723c4defe5f75ff1f31bfa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":55128782,"asset_id":35268161,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/55128782/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="35268161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="35268161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 35268161; 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</script> <div class="js-work-strip profile--work_container" data-work-id="30332025"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/30332025/ZikaLab_Manual_T%C3%A9cnico_de_forma%C3%A7%C3%A3o_do_trabalhador_de_sa%C3%BAde_no_contexto_do_V%C3%ADrus_Zika"><img alt="Research paper thumbnail of ZikaLab: Manual Técnico de formação do trabalhador de saúde no contexto do Vírus Zika" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/30332025/ZikaLab_Manual_T%C3%A9cnico_de_forma%C3%A7%C3%A3o_do_trabalhador_de_sa%C3%BAde_no_contexto_do_V%C3%ADrus_Zika">ZikaLab: Manual Técnico de formação do trabalhador de saúde no contexto do Vírus Zika</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/RaquelDoria">Raquel Doria</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30332025"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30332025"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30332025; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30332025]").text(description); $(".js-view-count[data-work-id=30332025]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30332025; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30332025']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30332025]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30332025,"title":"ZikaLab: Manual Técnico de formação do trabalhador de saúde no contexto do Vírus Zika","internal_url":"https://www.academia.edu/30332025/ZikaLab_Manual_T%C3%A9cnico_de_forma%C3%A7%C3%A3o_do_trabalhador_de_sa%C3%BAde_no_contexto_do_V%C3%ADrus_Zika","owner_id":57814767,"coauthors_can_edit":true,"owner":{"id":57814767,"first_name":"Raquel","middle_initials":null,"last_name":"Doria","page_name":"RaquelDoria","domain_name":"slmandic","created_at":"2016-12-08T07:38:43.345-08:00","display_name":"Raquel Doria","url":"https://slmandic.academia.edu/RaquelDoria"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="25033626"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/25033626/Spinal_Cord_Schistosomiasis"><img alt="Research paper thumbnail of Spinal Cord Schistosomiasis" class="work-thumbnail" src="https://attachments.academia-assets.com/45356086/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/25033626/Spinal_Cord_Schistosomiasis">Spinal Cord Schistosomiasis</a></div><div class="wp-workCard_item"><span>Parasitic Diseases - Schistosomiasis</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">share the same pattern in reproductive cycle, the transmission occurring through eggs, a proporti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">share the same pattern in reproductive cycle, the transmission occurring through eggs, a proportion of which are eliminated through urine (S. haematobium) or feces (S. mansoni, S. japonicum and others). These eggs release larvae (miracidium) that infect freshwater molluscs in which the parasites multiply through asexual reproduction. These molluscs release aquatic larvae (cercariae) that actively penetrate the skin of a new, vertebrate host. These larvae become adults that inhabit inside the veins in the digestive system (S. mansoni and S. japonicum) and of the urinary system (S. haematobium). The geographic distribution of each species is varied and depends on the presence of molluscs capable of serving as hosts (each Schistosoma species has different molluscs as hosts). Precarious sanitary conditions also contribute in the definition of locations where schistosomiasis occurs . Schistosoma mansoni occurs in 74 countries located in Africa, the Middle East, South America and the Caribbean. Its eggs measure about 60 x 140 μm, with lateral spine and are eliminated in the feces, being a main cause of intestinal, hepatosplenic, cardiopulmonary and cerebral diseases, aside from being the main cause of spinal cord schistosomiasis. S. haematobium occurs in Africa and in the Middle East and its eggs measure about 60 x 150 μm, with terminal spine, are eliminated in the urine and on rare occasions in the feces, being the mains cause of urinary diseases and spinal cord schistosomiasis. S. japonicum, S. mekongi and S. malayensis occur in Asia (they are also called S. japonicum-like); eggs measure about 60 x 100 μm, lack spine and are eliminated in the feces, causing hepatic diseases, cerebral neuroschistosomiasis, although there have been rare reports of cases in which spinal cord schistosomiasis was caused by S. japonicum. S. intercalatum occurs in Africa. Eggs are eliminated in the feces. It causes mild intestinal disease but not neuroschistosomiasis, being the least important species, clinically. The presence of spines in the eggs of S. mansoni and S. haematobium might explain why medullar and cerebral neuroschistosomiasis are more common in these species. Spine makes it more difficult for the eggs to travel through the vertebral veins, causing them to be stuck in the lumbar or thoracic spinal cord. S. japonium's eggs, being smaller and lacking spine, migrate more easily to the brain through these veins, crossing the spinal cord without sticking to it. There are, still, species belonging to the Schistosomatidae family (ex: Trichobilharzia regenti) that can cause cercarial dermatitis (or summer's itch) without, however, reaching adult life in men and, therefore, not having any major clinical importance. Parasitic Diseases -Schistosomiasis Spinal Cord Schistosomiasis <a href="http://dx.doi.org/10.5772/53771" rel="nofollow">http://dx.doi.org/10.5772/53771</a> Spinal Cord Schistosomiasis <a href="http://dx.doi.org/10.5772/53771" rel="nofollow">http://dx.doi.org/10.5772/53771</a> Parasitic Diseases -Schistosomiasis 132 Spinal Cord Schistosomiasis</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="706bcd0bf2088b46b090e55eb7cdd677" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45356086,"asset_id":25033626,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45356086/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="25033626"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="25033626"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 25033626; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="10534412"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/10534412/Chikungunya_in_Brazil_an_emerging_challenge"><img alt="Research paper thumbnail of Chikungunya in Brazil: an emerging challenge" class="work-thumbnail" src="https://attachments.academia-assets.com/36525160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/10534412/Chikungunya_in_Brazil_an_emerging_challenge">Chikungunya in Brazil: an emerging challenge</a></div><div class="wp-workCard_item"><span>REV BRAS EPIDEMIOL</span><span>, Jan 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">For the first time in history it was documented an indigenous transmission of Chikungunya fever i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">For the first time in history it was documented an indigenous transmission of Chikungunya fever in the Americas in the Caribbean in 2013. Then it has been confirmed in Oiapoque the occurrence in Brazil. By October 2014, there were 828 cases in the country, only 39 pointed as coming from abroad.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bc75313e7683d83cf33922f11af4a1c7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":36525160,"asset_id":10534412,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/36525160/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="10534412"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="10534412"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 10534412; 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A seguir, foi confirmada, no Oiapoque, <br />a ocorrência no Brasil. Até outubro de 2014, foram registrados 828 casos no país, sendo <br />somente 39 vindos do exterior.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6a170cf50da99d8ceb45b736890be0dc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":36494991,"asset_id":10468003,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/36494991/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="10468003"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="10468003"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 10468003; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="5733959"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/5733959/Unfortunately_pregnancy_did_increase_the_risk_of_death_during_the_2009_pandemic"><img alt="Research paper thumbnail of Unfortunately, pregnancy did increase the risk of death during the 2009 pandemic" class="work-thumbnail" src="https://attachments.academia-assets.com/32769471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/5733959/Unfortunately_pregnancy_did_increase_the_risk_of_death_during_the_2009_pandemic">Unfortunately, pregnancy did increase the risk of death during the 2009 pandemic</a></div><div class="wp-workCard_item"><span>BMJ</span><span>, Jan 16, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="634bba527a49e04a6190613e71c9c96c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":32769471,"asset_id":5733959,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/32769471/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="5733959"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="5733959"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5733959; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3710836"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3710836/Mortality_Associated_with_Influenza_in_Tropics_State_of_S%C3%A3o_Paulo_Brazil_from_2002_to_2011_The_Pre_Pandemic_Pandemic_and_Post_Pandemic_Periods"><img alt="Research paper thumbnail of Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: The Pre-Pandemic, Pandemic, and Post-Pandemic Periods" class="work-thumbnail" src="https://attachments.academia-assets.com/31392820/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3710836/Mortality_Associated_with_Influenza_in_Tropics_State_of_S%C3%A3o_Paulo_Brazil_from_2002_to_2011_The_Pre_Pandemic_Pandemic_and_Post_Pandemic_Periods">Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: The Pre-Pandemic, Pandemic, and Post-Pandemic Periods</a></div><div class="wp-workCard_item"><span>Influenza Research and Treatment</span><span>, Jun 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet completely understood, particularly in tropical and subtropical countries. The trends of influenza related mortality rate in different age groups and different outcomes on a area in tropical and subtropical climate with more than 41 million people (State of São Paulo, Brazil), were studied from 2002 to 2011 were studied. Serfling-type regression analysis was performed using weekly mortality registries and virological data obtained from sentinel surveillance. The prepandemic years presented a well-defined seasonality during winter and a clear relationship between activity of AH3N2 and increase of mortality in all ages, especially in individuals older than 60 years. The mortality due to pneumonia and influenza and respiratory causes associated with 2009 pandemic influenza in the age groups 0-4 years and older than 60 was lower than the previous years. Among people aged 5-19 and 20-59 years the mortality was 2.6 and 4.4 times higher than that in previous periods, respectively. The mortality in all ages was higher than the average of the previous years but was equal mortality in epidemics of AH3N2. The 2009 pandemic influenza mortality showed significant differences compared to other years, especially considering the age groups most affected.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="03032dfdecc14a71f163024929d36315" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31392820,"asset_id":3710836,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31392820/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3710836"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3710836"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3710836; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3710836]").text(description); $(".js-view-count[data-work-id=3710836]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3710836; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3710836']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "03032dfdecc14a71f163024929d36315" } } $('.js-work-strip[data-work-id=3710836]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3710836,"title":"Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: The Pre-Pandemic, Pandemic, and Post-Pandemic Periods","translated_title":"","metadata":{"ai_title_tag":"Influenza Mortality Trends in São Paulo, 2002-2011","grobid_abstract":"The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet completely understood, particularly in tropical and subtropical countries. The trends of influenza related mortality rate in different age groups and different outcomes on a area in tropical and subtropical climate with more than 41 million people (State of São Paulo, Brazil), were studied from 2002 to 2011 were studied. Serfling-type regression analysis was performed using weekly mortality registries and virological data obtained from sentinel surveillance. The prepandemic years presented a well-defined seasonality during winter and a clear relationship between activity of AH3N2 and increase of mortality in all ages, especially in individuals older than 60 years. The mortality due to pneumonia and influenza and respiratory causes associated with 2009 pandemic influenza in the age groups 0-4 years and older than 60 was lower than the previous years. Among people aged 5-19 and 20-59 years the mortality was 2.6 and 4.4 times higher than that in previous periods, respectively. The mortality in all ages was higher than the average of the previous years but was equal mortality in epidemics of AH3N2. The 2009 pandemic influenza mortality showed significant differences compared to other years, especially considering the age groups most affected.","publication_date":{"day":null,"month":6,"year":2013,"errors":{}},"publication_name":"Influenza Research and Treatment","grobid_abstract_attachment_id":31392820},"translated_abstract":null,"internal_url":"https://www.academia.edu/3710836/Mortality_Associated_with_Influenza_in_Tropics_State_of_S%C3%A3o_Paulo_Brazil_from_2002_to_2011_The_Pre_Pandemic_Pandemic_and_Post_Pandemic_Periods","translated_internal_url":"","created_at":"2013-06-14T04:35:32.977-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":1832802,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":19863147,"work_id":3710836,"tagging_user_id":1832802,"tagged_user_id":null,"co_author_invite_id":4496803,"email":"p***a@nepo.unicamp.br","display_order":0,"name":"Priscila Francisco","title":"Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: The Pre-Pandemic, Pandemic, and Post-Pandemic Periods"},{"id":19863149,"work_id":3710836,"tagging_user_id":1832802,"tagged_user_id":null,"co_author_invite_id":1336396,"email":"d***i@fcm.unicamp.br","display_order":4194304,"name":"Maria Donalisio","title":"Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: The Pre-Pandemic, Pandemic, and Post-Pandemic Periods"}],"downloadable_attachments":[{"id":31392820,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/31392820/thumbnails/1.jpg","file_name":"696274_FINAL.pdf","download_url":"https://www.academia.edu/attachments/31392820/download_file","bulk_download_file_name":"Mortality_Associated_with_Influenza_in_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/31392820/696274_FINAL-libre.pdf?1392316813=\u0026response-content-disposition=attachment%3B+filename%3DMortality_Associated_with_Influenza_in_T.pdf\u0026Expires=1738614856\u0026Signature=CWARtvGGCt7ig4fsvrooBSBTbKeUx9CLd87nRcQV0nvvR0~Wt0lOWfSKnTyXX7MH7DXuXu8YYye4BL~uVipXZqwxdtpUHrdk5Wn-xfsKti2eHbuhdZHN8nag8wcf7BvSUxkb3qS~kHVwLhVlTq7OoaZilAOiFvwVM4fGER29bc3p7wY1RFp~BhlIG0QNaYOBoqKwVRNKWyDgVnsjxN~AgN8ROuYE0HV6vGTU39PQLgj4WDp8YBxeZIDw~bjek6yrCJNmFnOYeCr6ZRkm689qPP5JXTc5uOMTltE8ZY65f746uu3IrHy51S0o3F2AVZFhYYZC5HmHDlGymAwDVqK3hA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Mortality_Associated_with_Influenza_in_Tropics_State_of_São_Paulo_Brazil_from_2002_to_2011_The_Pre_Pandemic_Pandemic_and_Post_Pandemic_Periods","translated_slug":"","page_count":10,"language":"en","content_type":"Work","summary":"The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet completely understood, particularly in tropical and subtropical countries. The trends of influenza related mortality rate in different age groups and different outcomes on a area in tropical and subtropical climate with more than 41 million people (State of São Paulo, Brazil), were studied from 2002 to 2011 were studied. Serfling-type regression analysis was performed using weekly mortality registries and virological data obtained from sentinel surveillance. The prepandemic years presented a well-defined seasonality during winter and a clear relationship between activity of AH3N2 and increase of mortality in all ages, especially in individuals older than 60 years. The mortality due to pneumonia and influenza and respiratory causes associated with 2009 pandemic influenza in the age groups 0-4 years and older than 60 was lower than the previous years. Among people aged 5-19 and 20-59 years the mortality was 2.6 and 4.4 times higher than that in previous periods, respectively. The mortality in all ages was higher than the average of the previous years but was equal mortality in epidemics of AH3N2. The 2009 pandemic influenza mortality showed significant differences compared to other years, especially considering the age groups most affected.","owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas 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Efeito da temperatura e umidade na transmissão de dengue e avaliação dos mecanismos de controle" class="work-thumbnail" src="https://attachments.academia-assets.com/31105020/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3250409/Efeito_da_temperatura_e_umidade_na_transmiss%C3%A3o_de_dengue_e_avalia%C3%A7%C3%A3o_dos_mecanismos_de_controle">Efeito da temperatura e umidade na transmissão de dengue e avaliação dos mecanismos de controle</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Temperatura e umidade influenciam fortemente a infestação de mosquitos. Porém a influência abióti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Temperatura e umidade influenciam fortemente a infestação de mosquitos. Porém a influência abiótica é suavizada na propagação de dengue. Há extremos de temperaturas, abaixo e acima das quais não há transmissão de dengue, mesmo que seja possível infestação por mosquitos. Os dados encontrados sugerem a necessidade de acompanhamento dos dados pluviométricos , de vigilância epidemiológica e sorotipos circulantes, pois podem colaborar bastante na elaboração de ações preventivas à dengue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6aafc84491888db062c896ed3950412f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31105020,"asset_id":3250409,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31105020/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3250409"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3250409"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3250409; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2347379"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2347379/Hematological_and_clinical_evaluation_of_345_acute_dengue_3_infections_patientes_during_2002_outbreak_in_Campinas_SP_Brazil"><img alt="Research paper thumbnail of Hematological and clinical evaluation of 345 acute dengue-3 infections patientes during 2002 outbreak in Campinas -SP - Brazil " class="work-thumbnail" src="https://attachments.academia-assets.com/30388777/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2347379/Hematological_and_clinical_evaluation_of_345_acute_dengue_3_infections_patientes_during_2002_outbreak_in_Campinas_SP_Brazil">Hematological and clinical evaluation of 345 acute dengue-3 infections patientes during 2002 outbreak in Campinas -SP - Brazil </a></div><div class="wp-workCard_item"><span>Virus Reviews and Research</span><span>, Jul 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">"Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients durin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">"Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil <br />Introduction: Dengue is the most important mosquito-borne viral disease. Hematological impact of DV infection has been described and the exact mechanism leading to the changes are not well understood yet. In the present study, clinical-hematological data obtained prospectively during 2002 outbreak in Campinas-SP-Brazil were analyzed. Methodology: Out and in-patients in a community were evaluated by the same group of physicians using a standard protocol. Overall, 345 patients were enrolled in the study: male 152(44.1%), female 193(55.9%); age range 9 months-75 years(median 28y); 55(15.9%) children, 290(84.1%) adults; 334(96.8%) cases were classified as Dengue Fever(DF), 9(2.6%) as Dengue Hemorrhagic Fever(DHF) and 2(0.6%) cases as Dengue Shock Syndrome(DSS) according to WHO criteria. All patients had DV infection confirmed by serology, performed by the public regional reference laboratory. Whole blood samples obtained from the patients were analyzed by automatic cell counter(Celldyn1400). Results: All patient presented with fever, 80.9% presented headache, 74.5% myalgia, 66.4% fatigue, 64.1% anorexia, 40.1% positive tourniquet test, 24.2% skin rashes. Bleeding symptoms were present in 10.7% of patients: epistaxis in 3.5%, gingival bleeding in 2.9%, melena in 2.0% and others like gynecological bleeding hematemesis and bleeding at venipuncture site. In 20 cases, it was not possible to obtain blood sample to perform the hemograme. Hematological changes found were thrombocytopenia(platelets<150x109/L) in 53.9% of cases(including all DHF/DSS cases) with mean nadir occurring in the 6th day after initial symptoms, leucopenia(leucocytes<3.5x106/L) in 52.8% of patients with mean nadir in the 4th day. The presence of thrombocytopenia was more frequent in leucopenic patients(OR=4.63, 2.67<OR<8.04, P<0.000001, 2=34.09). In 42 cases of DF(12.1%) serial hemogrames(3) were available. In these cases, mean of highest hematocrit occurred in the 5th day reaching 43.4% with a mean increase of 11.6%. Discussion: The results of the present study reinforce that DV infection have important impact on hematological parameter of patients. Moreover, the increase of hematocrit on 5th day after initial symptoms, suggests that hemoconcentration may also occur on DF cases although in a lesser extent than in DHF/DSS. The presence of earlier leucopenia suggests also a 4-fold higher risk of development of thrombocytopenia. The mechanisms leading to these findings must be better explored. <br /> <br />Abstract/Author(s) Details <br />-------------------------- <br />TITLE: Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil <br /> <br />AUTHORS: André Ricardo Ribas Freitas, Nicole Montenegro Medeiros Coelho, Brigina Kemp, Rodrigo Nogueira Angerami, Fernanda Loureiro Orsi,  Luiz Jacintho da Silva, Vagner Castro <br />DEPT: Coordenadoria de Vigilância em Saúde - Secretaria Municipal de Saúde; Faculdade de Ciências Médicas <br />INST: Prefeitura Municipal de Campinas - Campinas  - SP - Brazil; Universidade Estadual de Campinas - UNICAMP</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="19d4ca03b1d347c60678b85311679c3f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":30388777,"asset_id":2347379,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/30388777/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2347379"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2347379"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2347379; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=2347379]").text(description); $(".js-view-count[data-work-id=2347379]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 2347379; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='2347379']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "19d4ca03b1d347c60678b85311679c3f" } } $('.js-work-strip[data-work-id=2347379]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":2347379,"title":"Hematological and clinical evaluation of 345 acute dengue-3 infections patientes during 2002 outbreak in Campinas -SP - Brazil ","translated_title":"","metadata":{"abstract":"\"Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\nIntroduction: Dengue is the most important mosquito-borne viral disease. Hematological impact of DV infection has been described and the exact mechanism leading to the changes are not well understood yet. In the present study, clinical-hematological data obtained prospectively during 2002 outbreak in Campinas-SP-Brazil were analyzed. Methodology: Out and in-patients in a community were evaluated by the same group of physicians using a standard protocol. Overall, 345 patients were enrolled in the study: male 152(44.1%), female 193(55.9%); age range 9 months-75 years(median 28y); 55(15.9%) children, 290(84.1%) adults; 334(96.8%) cases were classified as Dengue Fever(DF), 9(2.6%) as Dengue Hemorrhagic Fever(DHF) and 2(0.6%) cases as Dengue Shock Syndrome(DSS) according to WHO criteria. All patients had DV infection confirmed by serology, performed by the public regional reference laboratory. Whole blood samples obtained from the patients were analyzed by automatic cell counter(Celldyn1400). Results: All patient presented with fever, 80.9% presented headache, 74.5% myalgia, 66.4% fatigue, 64.1% anorexia, 40.1% positive tourniquet test, 24.2% skin rashes. Bleeding symptoms were present in 10.7% of patients: epistaxis in 3.5%, gingival bleeding in 2.9%, melena in 2.0% and others like gynecological bleeding hematemesis and bleeding at venipuncture site. In 20 cases, it was not possible to obtain blood sample to perform the hemograme. Hematological changes found were thrombocytopenia(platelets\u003c150x109/L) in 53.9% of cases(including all DHF/DSS cases) with mean nadir occurring in the 6th day after initial symptoms, leucopenia(leucocytes\u003c3.5x106/L) in 52.8% of patients with mean nadir in the 4th day. The presence of thrombocytopenia was more frequent in leucopenic patients(OR=4.63, 2.67\u003cOR\u003c8.04, P\u003c0.000001, 2=34.09). In 42 cases of DF(12.1%) serial hemogrames(3) were available. In these cases, mean of highest hematocrit occurred in the 5th day reaching 43.4% with a mean increase of 11.6%. Discussion: The results of the present study reinforce that DV infection have important impact on hematological parameter of patients. Moreover, the increase of hematocrit on 5th day after initial symptoms, suggests that hemoconcentration may also occur on DF cases although in a lesser extent than in DHF/DSS. The presence of earlier leucopenia suggests also a 4-fold higher risk of development of thrombocytopenia. The mechanisms leading to these findings must be better explored.\r\n\r\nAbstract/Author(s) Details\r\n--------------------------\r\nTITLE: Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\n \r\nAUTHORS: André Ricardo Ribas Freitas, Nicole Montenegro Medeiros Coelho, Brigina Kemp, Rodrigo Nogueira Angerami, Fernanda Loureiro Orsi, Luiz Jacintho da Silva, Vagner Castro \r\nDEPT: Coordenadoria de Vigilância em Saúde - Secretaria Municipal de Saúde; Faculdade de Ciências Médicas \r\nINST: Prefeitura Municipal de Campinas - Campinas - SP - Brazil; Universidade Estadual de Campinas - UNICAMP ","publication_date":{"day":null,"month":7,"year":2008,"errors":{}},"publication_name":"Virus Reviews and Research"},"translated_abstract":"\"Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\nIntroduction: Dengue is the most important mosquito-borne viral disease. Hematological impact of DV infection has been described and the exact mechanism leading to the changes are not well understood yet. In the present study, clinical-hematological data obtained prospectively during 2002 outbreak in Campinas-SP-Brazil were analyzed. Methodology: Out and in-patients in a community were evaluated by the same group of physicians using a standard protocol. Overall, 345 patients were enrolled in the study: male 152(44.1%), female 193(55.9%); age range 9 months-75 years(median 28y); 55(15.9%) children, 290(84.1%) adults; 334(96.8%) cases were classified as Dengue Fever(DF), 9(2.6%) as Dengue Hemorrhagic Fever(DHF) and 2(0.6%) cases as Dengue Shock Syndrome(DSS) according to WHO criteria. All patients had DV infection confirmed by serology, performed by the public regional reference laboratory. Whole blood samples obtained from the patients were analyzed by automatic cell counter(Celldyn1400). Results: All patient presented with fever, 80.9% presented headache, 74.5% myalgia, 66.4% fatigue, 64.1% anorexia, 40.1% positive tourniquet test, 24.2% skin rashes. Bleeding symptoms were present in 10.7% of patients: epistaxis in 3.5%, gingival bleeding in 2.9%, melena in 2.0% and others like gynecological bleeding hematemesis and bleeding at venipuncture site. In 20 cases, it was not possible to obtain blood sample to perform the hemograme. Hematological changes found were thrombocytopenia(platelets\u003c150x109/L) in 53.9% of cases(including all DHF/DSS cases) with mean nadir occurring in the 6th day after initial symptoms, leucopenia(leucocytes\u003c3.5x106/L) in 52.8% of patients with mean nadir in the 4th day. The presence of thrombocytopenia was more frequent in leucopenic patients(OR=4.63, 2.67\u003cOR\u003c8.04, P\u003c0.000001, 2=34.09). In 42 cases of DF(12.1%) serial hemogrames(3) were available. In these cases, mean of highest hematocrit occurred in the 5th day reaching 43.4% with a mean increase of 11.6%. Discussion: The results of the present study reinforce that DV infection have important impact on hematological parameter of patients. Moreover, the increase of hematocrit on 5th day after initial symptoms, suggests that hemoconcentration may also occur on DF cases although in a lesser extent than in DHF/DSS. The presence of earlier leucopenia suggests also a 4-fold higher risk of development of thrombocytopenia. The mechanisms leading to these findings must be better explored.\r\n\r\nAbstract/Author(s) Details\r\n--------------------------\r\nTITLE: Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\n \r\nAUTHORS: André Ricardo Ribas Freitas, Nicole Montenegro Medeiros Coelho, Brigina Kemp, Rodrigo Nogueira Angerami, Fernanda Loureiro Orsi, Luiz Jacintho da Silva, Vagner Castro \r\nDEPT: Coordenadoria de Vigilância em Saúde - Secretaria Municipal de Saúde; Faculdade de Ciências Médicas \r\nINST: Prefeitura Municipal de Campinas - Campinas - SP - Brazil; Universidade Estadual de Campinas - UNICAMP ","internal_url":"https://www.academia.edu/2347379/Hematological_and_clinical_evaluation_of_345_acute_dengue_3_infections_patientes_during_2002_outbreak_in_Campinas_SP_Brazil","translated_internal_url":"","created_at":"2013-01-01T11:39:26.171-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":1832802,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":19863146,"work_id":2347379,"tagging_user_id":1832802,"tagged_user_id":817214,"co_author_invite_id":null,"email":"l***n@yahoo.de","affiliation":"Universidade Federal do Paraná","display_order":0,"name":"Luiz Everson da Silva","title":"Hematological and clinical evaluation of 345 acute dengue-3 infections patientes during 2002 outbreak in Campinas -SP - Brazil "},{"id":32249827,"work_id":2347379,"tagging_user_id":1832802,"tagged_user_id":33382504,"co_author_invite_id":null,"email":"v***r@unicamp.br","display_order":4194304,"name":"V. 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Hematological impact of DV infection has been described and the exact mechanism leading to the changes are not well understood yet. In the present study, clinical-hematological data obtained prospectively during 2002 outbreak in Campinas-SP-Brazil were analyzed. Methodology: Out and in-patients in a community were evaluated by the same group of physicians using a standard protocol. Overall, 345 patients were enrolled in the study: male 152(44.1%), female 193(55.9%); age range 9 months-75 years(median 28y); 55(15.9%) children, 290(84.1%) adults; 334(96.8%) cases were classified as Dengue Fever(DF), 9(2.6%) as Dengue Hemorrhagic Fever(DHF) and 2(0.6%) cases as Dengue Shock Syndrome(DSS) according to WHO criteria. All patients had DV infection confirmed by serology, performed by the public regional reference laboratory. Whole blood samples obtained from the patients were analyzed by automatic cell counter(Celldyn1400). Results: All patient presented with fever, 80.9% presented headache, 74.5% myalgia, 66.4% fatigue, 64.1% anorexia, 40.1% positive tourniquet test, 24.2% skin rashes. Bleeding symptoms were present in 10.7% of patients: epistaxis in 3.5%, gingival bleeding in 2.9%, melena in 2.0% and others like gynecological bleeding hematemesis and bleeding at venipuncture site. In 20 cases, it was not possible to obtain blood sample to perform the hemograme. Hematological changes found were thrombocytopenia(platelets\u003c150x109/L) in 53.9% of cases(including all DHF/DSS cases) with mean nadir occurring in the 6th day after initial symptoms, leucopenia(leucocytes\u003c3.5x106/L) in 52.8% of patients with mean nadir in the 4th day. The presence of thrombocytopenia was more frequent in leucopenic patients(OR=4.63, 2.67\u003cOR\u003c8.04, P\u003c0.000001, 2=34.09). In 42 cases of DF(12.1%) serial hemogrames(3) were available. In these cases, mean of highest hematocrit occurred in the 5th day reaching 43.4% with a mean increase of 11.6%. Discussion: The results of the present study reinforce that DV infection have important impact on hematological parameter of patients. Moreover, the increase of hematocrit on 5th day after initial symptoms, suggests that hemoconcentration may also occur on DF cases although in a lesser extent than in DHF/DSS. The presence of earlier leucopenia suggests also a 4-fold higher risk of development of thrombocytopenia. The mechanisms leading to these findings must be better explored.\r\n\r\nAbstract/Author(s) Details\r\n--------------------------\r\nTITLE: Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\n \r\nAUTHORS: André Ricardo Ribas Freitas, Nicole Montenegro Medeiros Coelho, Brigina Kemp, Rodrigo Nogueira Angerami, Fernanda Loureiro Orsi, Luiz Jacintho da Silva, Vagner Castro \r\nDEPT: Coordenadoria de Vigilância em Saúde - Secretaria Municipal de Saúde; Faculdade de Ciências Médicas \r\nINST: Prefeitura Municipal de Campinas - Campinas - SP - Brazil; Universidade Estadual de Campinas - UNICAMP ","owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas Freitas","url":"https://slmandic.academia.edu/AndreRicardoRibasFreitas"},"attachments":[{"id":30388777,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/30388777/thumbnails/1.jpg","file_name":"Dengue_Hemograma_PanAmericano_Recife_2008.pdf","download_url":"https://www.academia.edu/attachments/30388777/download_file","bulk_download_file_name":"Hematological_and_clinical_evaluation_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/30388777/Dengue_Hemograma_PanAmericano_Recife_2008-libre.pdf?1390886399=\u0026response-content-disposition=attachment%3B+filename%3DHematological_and_clinical_evaluation_of.pdf\u0026Expires=1738614856\u0026Signature=ZLUhvovoJzYXOSCNXiAnIfj9K8Pt2saZ4KK42VDt7ncGnveTRoegDKN7TegFdrinWDSf6YbRuBnfe1PhYgZXBsbrFBc2Ig3~CzsGxB2IeauSrZI9VpioPRgdlHgt-XRTHtuvGmNCkMgN-Q1xLeAL8KooiFVIWbM77Sa7UtX7qJkXTmP1KNEYRJihXt6OZ410hWBrDOSXs3fpyhujZt-A86QMMjrRKj-aVWRtyVePsE7PRuT3jw0J6YoIaRdj6~lEwfJK-GW4f8~gzq2AfpfMJTqH12Jz3KIYh2MGOndXaws3VRVydr3LTATADv5gM1fA2zEiPw3ck7GVCzvki7aViA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology"},{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology"},{"id":7823,"name":"Malaria","url":"https://www.academia.edu/Documents/in/Malaria"},{"id":8241,"name":"Tropical Medicine","url":"https://www.academia.edu/Documents/in/Tropical_Medicine"},{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":22844,"name":"Insect Molecular Biology","url":"https://www.academia.edu/Documents/in/Insect_Molecular_Biology"},{"id":24882,"name":"Medical Entomology","url":"https://www.academia.edu/Documents/in/Medical_Entomology"},{"id":157268,"name":"Dengue","url":"https://www.academia.edu/Documents/in/Dengue"},{"id":1115412,"name":"Vector Biology \u0026 Control","url":"https://www.academia.edu/Documents/in/Vector_Biology_and_Control-1"},{"id":1115413,"name":"Biochemical Entomology","url":"https://www.academia.edu/Documents/in/Biochemical_Entomology"}],"urls":[{"id":435560,"url":"http://www.virusreviewsandresearch.com/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2157529"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2157529/Co_infection_between_the_pandemic_influenza_virus_A_H1N1_and_seasonal_influenza_A_virus_in_a_patient_presenting_severe_acute_respiratory_disease"><img alt="Research paper thumbnail of Co-infection between the pandemic influenza virus A H1N1 and seasonal influenza A virus in a patient presenting severe acute respiratory disease" class="work-thumbnail" src="https://attachments.academia-assets.com/30212517/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2157529/Co_infection_between_the_pandemic_influenza_virus_A_H1N1_and_seasonal_influenza_A_virus_in_a_patient_presenting_severe_acute_respiratory_disease">Co-infection between the pandemic influenza virus A H1N1 and seasonal influenza A virus in a patient presenting severe acute respiratory disease</a></div><div class="wp-workCard_item"><span>International Journal of Infectious Diseases</span><span>, Mar 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstracts e103 members, were followed up with home visits to determine secondary infections in th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstracts e103 members, were followed up with home visits to determine secondary infections in the household. Serum samples taken at baseline and convalescence were tested for HAI specific to pandemic H1N1, seasonal H1N1 and seasonal H3N2. Nasal and throat swabs (NTS) were collected from each individual and tested by RTPCR to confirm active infections.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="68589c837c3c909ef63cebfae48250ac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":30212517,"asset_id":2157529,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/30212517/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2157529"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2157529"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2157529; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2040239"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2040239/Clusters_of_Brazilian_spotted_fever_in_Sa_o_Paulo_State_southeastern_Brazil_A_review_of_official_reports_and_the_scientific_literature"><img alt="Research paper thumbnail of Clusters of Brazilian spotted fever in Sa˜o Paulo State, southeastern Brazil. A review of ofﬁcial reports and the scientiﬁc literature" class="work-thumbnail" src="https://attachments.academia-assets.com/29558776/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2040239/Clusters_of_Brazilian_spotted_fever_in_Sa_o_Paulo_State_southeastern_Brazil_A_review_of_official_reports_and_the_scientific_literature">Clusters of Brazilian spotted fever in Sa˜o Paulo State, southeastern Brazil. A review of ofﬁcial reports and the scientiﬁc literature</a></div><div class="wp-workCard_item"><span>Clinical Microbiology and Infectious Diseases</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c71561d1f7e54fff2b41f8fccfcc32eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":29558776,"asset_id":2040239,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/29558776/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2040239"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2040239"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2040239; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=2040239]").text(description); $(".js-view-count[data-work-id=2040239]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 2040239; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='2040239']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c71561d1f7e54fff2b41f8fccfcc32eb" } } $('.js-work-strip[data-work-id=2040239]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":2040239,"title":"Clusters of Brazilian spotted fever in Sa˜o Paulo State, southeastern Brazil. 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Enquanto os órgãos pertinentes não solucionam os gargalos no fluxo de informações de vital importância, epidemiólogos e outros pesquisadores devem produzir subsídios técnicos para o enfrentamento da crise contornando essas limitações. No presente estudo, focado no Brasil, comparamos os óbitos pelo SARS-CoV-2, disponibilizados diariamente, com os dados de óbitos por doenças respiratórias e outras doenças nos anos de 2014 a 2018 (os últimos cinco anos completos para os quais os dados estão disponíveis). Adicionalmente, extraímos os sinais temporais anuais dos óbitos por doenças respiratórias para que o período típico de pico na mortalidade por essas do enças possa ser considerado em cada estado Brasileiro. A porcentagem de óbitos pelo SARS-CoV-2 até o dia 15 de abril equivale a 24% da mortalidade esperada por causas respiratórias no mesmo período, com base em anos anteriores, com grande variação entre os estados (desde o Amazonas, 151%, até o Tocantins, com 3%). Estamos na época típica de pico de mortalidade associada a doenças respiratórias em grande parte do Norte e Nordeste (com exceção de Roraima). Nas regiões Sudeste e Sul, esse pico é mais tardio (junho-agosto). A evolução da pandemia em cada estado dependerá, no entanto, de vários outros fatores, como o comportamento do patógeno-ainda não conhecido suficientemente. Ressaltamos a necessidade de ações para aumento da agilidade na disponibilização dos dados atuais de mortalidade (por diversas causas), para que equipes de pesquisa com diferentes abordagens analíticas possam se somar no combate a este desafio sanitário global.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="52b2349efcfdd4cf1c5348ce7fd83012" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63220982,"asset_id":42963884,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63220982/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="42963884"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="42963884"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 42963884; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=42963884]").text(description); $(".js-view-count[data-work-id=42963884]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 42963884; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='42963884']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "52b2349efcfdd4cf1c5348ce7fd83012" } } $('.js-work-strip[data-work-id=42963884]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":42963884,"title":"Covid-19 em contexto: comparação com a mortalidade mensal por causas respiratórias nos estados brasileiros","internal_url":"https://www.academia.edu/42963884/Covid_19_em_contexto_compara%C3%A7%C3%A3o_com_a_mortalidade_mensal_por_causas_respirat%C3%B3rias_nos_estados_brasileiros","owner_id":157086094,"coauthors_can_edit":true,"owner":{"id":157086094,"first_name":"COVID","middle_initials":null,"last_name":"19","page_name":"COVID19","domain_name":"ufpa","created_at":"2020-05-06T12:45:37.775-07:00","display_name":"COVID 19","url":"https://ufpa.academia.edu/COVID19"},"attachments":[{"id":63220982,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63220982/thumbnails/1.jpg","file_name":"93-Article_Text-450-1-10-20200506_120200506-82766-xjk814.pdf","download_url":"https://www.academia.edu/attachments/63220982/download_file","bulk_download_file_name":"Covid_19_em_contexto_comparacao_com_a_mo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63220982/93-Article_Text-450-1-10-20200506_120200506-82766-xjk814-libre.pdf?1588799376=\u0026response-content-disposition=attachment%3B+filename%3DCovid_19_em_contexto_comparacao_com_a_mo.pdf\u0026Expires=1740174660\u0026Signature=goH~pADmuuJ~fxLDdNZ9H0xxNyVy1hW1iTTSPc39rPRijU0NaPT2mTffd~fG~ZW7wdDyQPlCfLAWNG-56h~DYmICGK8Z3aOLWv2agu~PpkWhZ9Gi4zYoy6bP7Fg1vtMIhsGol8AavqjxnJv4V1KD~0GFfW5qUNBfMCOcwgF-a2yHfbSJ~nibYj4tDHtcC-uIKLZZFDAB1jCBUY7TjjU-2RXLFlcmV2xNuW6hLN2~CKYcIntMWudqKyMrIIptZ-CjwYuo9zSt7lR4zlndDO7yeBiDZQqQQ628SuvufpTwo9sNs8KE8veOPfOhPg21b9YamTEw1i0WUocsXl473ByKPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43152542"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43152542/Respiratory_syncytial_virus_causes_more_hospitalizations_and_deaths_in_equatorial_Brazil_than_influenza_including_during_the_2009_pandemic_"><img alt="Research paper thumbnail of Respiratory syncytial virus causes more hospitalizations and deaths in equatorial Brazil than influenza (including during the 2009 pandemic)" class="work-thumbnail" src="https://attachments.academia-assets.com/63413830/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43152542/Respiratory_syncytial_virus_causes_more_hospitalizations_and_deaths_in_equatorial_Brazil_than_influenza_including_during_the_2009_pandemic_">Respiratory syncytial virus causes more hospitalizations and deaths in equatorial Brazil than influenza (including during the 2009 pandemic)</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite numerous studies evaluating influenza and Respiratory Syncytial Virus (RSV), there is sti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite numerous studies evaluating influenza and Respiratory Syncytial Virus (RSV), there is still a lack of knowledge about them, especially in tropical countries. We compared the relative importance of respiratory viruses by examining their spatiotemporal patterns, age-specific hospitalization data and mortality data for 2007-2012 obtained from official sources. The data were aggregated into “respiratory infection seasonal zones” formed combining states that had similar seasonal patterns of pneumonia and influenza (P&I). Equatorial-North where P&I peaks in the middle of the year, Equatorial-South where P&I peaks in the first semester and coincides with the rainy-season, Subtropical where P&I peaks are clearly concentrated in the winter season, and Tropical Midwest and South-East where P&I peaks are a transition between the South-Equatorial and the Sub-tropical. Our analyses indicate that RSV has higher impact than influenza in equatorial region of Brazil, which was particularly evident during the circulation of the 2009pdm strain, and suggests that seasonal influenza may have a lower impact in Equatorial Brazil (and perhaps in other tropical regions of the world) than previously considered. Accordingly, we suggest that the broad assumption that influenza is the main cause of viral respiratory hospitalizations and death in equatorial regions be questioned with greater emphasis in future studies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16256c50a93dd70e6425875efa1f926c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63413830,"asset_id":43152542,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63413830/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43152542"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43152542"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43152542; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43152542]").text(description); $(".js-view-count[data-work-id=43152542]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43152542; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43152542']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43152510"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43152510/Dentistry_vs_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_How_to_face_this_enemy"><img alt="Research paper thumbnail of Dentistry vs Severe Acute Respiratory Syndrome Coronavirus 2: How to face this enemy" class="work-thumbnail" src="https://attachments.academia-assets.com/63413794/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43152510/Dentistry_vs_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_How_to_face_this_enemy">Dentistry vs Severe Acute Respiratory Syndrome Coronavirus 2: How to face this enemy</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/MarceloNapimoga">Marcelo Napimoga</a></span></div><div class="wp-workCard_item"><span>RGO, Rev Gaúch Odontol.</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Since the beginning of the SARS-CoV-2 pandemic, numerous restrictive measures have been taken by ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Since the beginning of the SARS-CoV-2 pandemic, numerous restrictive measures have been taken by the governments of different countries. Recently, due to the high possibility of transmission in dental offices, there was a recommendation by the American, European and Brazilian governments to request the closing of the offices. In this commentary, we will give an overview of the reasons and perspectives of this scenario.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7dba1dee66b47c14716caebee5dc651c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63413794,"asset_id":43152510,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63413794/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43152510"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43152510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43152510; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43152510]").text(description); $(".js-view-count[data-work-id=43152510]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43152510; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43152510']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7dba1dee66b47c14716caebee5dc651c" } } $('.js-work-strip[data-work-id=43152510]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43152510,"title":"Dentistry vs Severe Acute Respiratory Syndrome Coronavirus 2: How to face this enemy","internal_url":"https://www.academia.edu/43152510/Dentistry_vs_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_How_to_face_this_enemy","owner_id":1832802,"coauthors_can_edit":true,"owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas Freitas","url":"https://slmandic.academia.edu/AndreRicardoRibasFreitas"},"attachments":[{"id":63413794,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63413794/thumbnails/1.jpg","file_name":"1981-8637-rgo-68-e2020001120200524-71431-1k7av8x.pdf","download_url":"https://www.academia.edu/attachments/63413794/download_file","bulk_download_file_name":"Dentistry_vs_Severe_Acute_Respiratory_Sy.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63413794/1981-8637-rgo-68-e2020001120200524-71431-1k7av8x-libre.pdf?1590359087=\u0026response-content-disposition=attachment%3B+filename%3DDentistry_vs_Severe_Acute_Respiratory_Sy.pdf\u0026Expires=1740341698\u0026Signature=DIHLF9HbluWsmr-VxUExQcnWxtMnmE-fF1bJi9-AcTq~ZrsZ3vjc0SXzaO3d4SaJUZtweoaFVs3niC7i-dMpRG3ZRJaia0s~b2X6XDuUxuvYfxrRmf6e2HcS-X6r7aEgTArwUpsY9Mi~r0nKEmzKCX3eY38iRa7JsGsX7Xtva-kfNQVapqjnOK7ddgTm3Odq80XTNBpLCcDLA8JkIwyTkgoNZj8-D4M47PaMv72EEKvuQ8PTx9fRO13cgIpsh8JjC~YaHwSEHwMUEbC39ySdyMI28USF-f~T6qib9BFYI~z0W45aoW5Edh4WIqsLE3HJytnbEzxBrGUS-WBAMq5UUA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="43147932"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/43147932/Assessing_the_severity_of_COVID_19"><img alt="Research paper thumbnail of Assessing the severity of COVID-19" class="work-thumbnail" src="https://attachments.academia-assets.com/63408227/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/43147932/Assessing_the_severity_of_COVID_19">Assessing the severity of COVID-19</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/MarceloNapimoga">Marcelo Napimoga</a></span></div><div class="wp-workCard_item"><span>Revista Epidemiologia e Serviços de Saúde</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="39b2c08ccc08bd4479ec7fad39f3c02b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63408227,"asset_id":43147932,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63408227/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="43147932"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="43147932"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 43147932; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=43147932]").text(description); $(".js-view-count[data-work-id=43147932]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 43147932; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='43147932']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "39b2c08ccc08bd4479ec7fad39f3c02b" } } $('.js-work-strip[data-work-id=43147932]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":43147932,"title":"Assessing the severity of COVID-19","internal_url":"https://www.academia.edu/43147932/Assessing_the_severity_of_COVID_19","owner_id":1832802,"coauthors_can_edit":true,"owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas Freitas","url":"https://slmandic.academia.edu/AndreRicardoRibasFreitas"},"attachments":[{"id":63408227,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63408227/thumbnails/1.jpg","file_name":"en_2237-9622-ress-29-02-e202011920200523-7248-64z9l5.pdf","download_url":"https://www.academia.edu/attachments/63408227/download_file","bulk_download_file_name":"Assessing_the_severity_of_COVID_19.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63408227/en_2237-9622-ress-29-02-e202011920200523-7248-64z9l5-libre.pdf?1590293492=\u0026response-content-disposition=attachment%3B+filename%3DAssessing_the_severity_of_COVID_19.pdf\u0026Expires=1740341698\u0026Signature=WicBmMIDm--XDENcFJVDLkV5ab3V5x44uQreWVMgKusMxRiCovVgLUC8mk3WWwvdaaQPyra7G3WYJsJ7LaYhdd78xfzSZdiwXeCbU8HTjHmKUQ6c7ckj8lazX6ndRo3ohkPLKrL-mI7CF~-HM8Pxm4zdEhYr~K~0O74GPP4UiSeXy4zh7e5vlIp0Jc-9b65r68ttkpdYG3cR3XLSbfbmqkPUbXMzYAExerPer~Ghcu3v4sqCiKz5AzhqAmnp~KsFWhTrY2da0FyLL2eEk7urrF3pjrd3MeOu5wIPGocd-k1GekjyjOSQFp-tdMVEtmqdpfLl~HYiUyI9j4iq6TFTcw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="37185265"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/37185265/Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic_2014"><img alt="Research paper thumbnail of Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014" class="work-thumbnail" src="https://attachments.academia-assets.com/63372102/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/37185265/Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic_2014">Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RobertPaulinoRamirez">Robert Paulino-Ramirez</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MariaRitaDonalisio">Maria Rita Donalisio</a></span></div><div class="wp-workCard_item"><span>Transactions of The Royal Society of Tropical Medicine and Hygiene</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 09...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic. Methods: Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic. Results: The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (>99% confidence interval) among individuals <5 y and >40 y of age. The mortality rates were higher among the elderly. The death excess was 2853. Correcting for the estimated underreporting, there were 4952 deaths during the chikungunya epidemic (49.8 deaths/100 000 population). Conclusion: This study suggests that chikungunya is an important cause of death (underlying or contributing). It is urgent to review clinical protocols and investigate the causes associated with deaths during chikungunya epidemics.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f0fe3c46beddfa2885e974dd9fb5fd2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":63372102,"asset_id":37185265,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/63372102/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="37185265"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="37185265"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 37185265; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=37185265]").text(description); $(".js-view-count[data-work-id=37185265]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 37185265; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='37185265']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f0fe3c46beddfa2885e974dd9fb5fd2" } } $('.js-work-strip[data-work-id=37185265]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":37185265,"title":"Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014","translated_title":"","metadata":{"abstract":"Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic. Methods: Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic. Results: The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (\u003e99% confidence interval) among individuals \u003c5 y and \u003e40 y of age. The mortality rates were higher among the elderly. The death excess was 2853. Correcting for the estimated underreporting, there were 4952 deaths during the chikungunya epidemic (49.8 deaths/100 000 population). Conclusion: This study suggests that chikungunya is an important cause of death (underlying or contributing). It is urgent to review clinical protocols and investigate the causes associated with deaths during chikungunya epidemics.","ai_title_tag":"Excess Deaths in 2014 Chikungunya Epidemic","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Transactions of The Royal Society of Tropical Medicine and Hygiene"},"translated_abstract":"Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic. Methods: Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic. Results: The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (\u003e99% confidence interval) among individuals \u003c5 y and \u003e40 y of age. The mortality rates were higher among the elderly. The death excess was 2853. Correcting for the estimated underreporting, there were 4952 deaths during the chikungunya epidemic (49.8 deaths/100 000 population). Conclusion: This study suggests that chikungunya is an important cause of death (underlying or contributing). It is urgent to review clinical protocols and investigate the causes associated with deaths during chikungunya epidemics.","internal_url":"https://www.academia.edu/37185265/Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic_2014","translated_internal_url":"","created_at":"2018-08-05T19:27:34.712-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":1832802,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":31770861,"work_id":37185265,"tagging_user_id":1832802,"tagged_user_id":302555506,"co_author_invite_id":182404,"email":"p***n@uv.es","display_order":0,"name":"Pedro Alarcón-Elbal","title":"Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014"},{"id":31770862,"work_id":37185265,"tagging_user_id":1832802,"tagged_user_id":88554679,"co_author_invite_id":6731437,"email":"r***1@unibe.edu.do","display_order":4194304,"name":"Robert Paulino-Ramirez","title":"Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014"},{"id":31770863,"work_id":37185265,"tagging_user_id":1832802,"tagged_user_id":42712700,"co_author_invite_id":null,"email":"r***o@gmail.com","display_order":6291456,"name":"Maria Rita Donalisio","title":"Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014"}],"downloadable_attachments":[{"id":63372102,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/63372102/thumbnails/1.jpg","file_name":"Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic__2014_10.1093_trstmh_try072.pdf","download_url":"https://www.academia.edu/attachments/63372102/download_file","bulk_download_file_name":"Excess_mortality_profile_during_the_Asia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/63372102/Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic__2014_10.1093_trstmh_try072-libre.pdf?1589976999=\u0026response-content-disposition=attachment%3B+filename%3DExcess_mortality_profile_during_the_Asia.pdf\u0026Expires=1738716977\u0026Signature=AMdjFI2ZBiEW9k6O6RjYtbRKcdRc2~i0qXVDcfN-YfFqjl~eBNv2MdN9sJB17bttNVgyq4PLxthkqsesEy2eXa66XRpZIUbgZqshKPQYvs8h46hZJ2LOj8ce-g7gO~o5QhZ-HnmdBm-Kf3gZz4hzLsjutvml9ijXMdH3cUrkJwotSxEKhyPAm8xZDTub6qOBHIqbZ6vYzpQ2bWmttZ70w4ik7yxYCB-5NkZ4xE9QhrA~VQrf8O3LwHz8Zj1wlvkSgfgn194A2MgoS097DJVnyK3jJZCmP5MQcK6LsJ3NZvNpaIjp-oRrl9AJBAqjHdZAGPeeWARgJhKCNWvmRXnxqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Excess_mortality_profile_during_the_Asian_genotype_chikungunya_epidemic_in_the_Dominican_Republic_2014","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"Background: In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic. Methods: Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic. Results: The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (\u003e99% confidence interval) among individuals \u003c5 y and \u003e40 y of age. The mortality rates were higher among the elderly. The death excess was 2853. Correcting for the estimated underreporting, there were 4952 deaths during the chikungunya epidemic (49.8 deaths/100 000 population). Conclusion: This study suggests that chikungunya is an important cause of death (underlying or contributing). It is urgent to review clinical protocols and investigate the causes associated with deaths during chikungunya epidemics.","owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas 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and Hemorrhagic Fevers","url":"https://www.academia.edu/Documents/in/Arboviruses_and_Hemorrhagic_Fevers"},{"id":1308498,"name":"Chikungunya Virus and Other Arboviruses","url":"https://www.academia.edu/Documents/in/Chikungunya_Virus_and_Other_Arboviruses"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="35268161"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/35268161/Excess_Mortality_Related_to_Chikungunya_Epidemics_in_the_Context_of_Co_circulation_of_Other_Arboviruses_in_Brazil"><img alt="Research paper thumbnail of Excess Mortality Related to Chikungunya Epidemics in the Context of Co-circulation of Other Arboviruses in Brazil" class="work-thumbnail" src="https://attachments.academia-assets.com/55128782/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/35268161/Excess_Mortality_Related_to_Chikungunya_Epidemics_in_the_Context_of_Co_circulation_of_Other_Arboviruses_in_Brazil">Excess Mortality Related to Chikungunya Epidemics in the Context of Co-circulation of Other Arboviruses in Brazil</a></div><div class="wp-workCard_item"><span>PLoS Currents</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: Chikungunya is an emerging arbovirus that reached the Western Hemisphere at the end...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: Chikungunya is an emerging arbovirus that reached the Western Hemisphere at the end of 2013. Studies in the Indian Ocean and India suggest that passive surveillance systems cannot recognize many of deaths associated with chikungunya, which can be inferred by an increase in the overall mortality observed during chikungunya epidemics.<br /><br />Objective: We assess the mortality associated with chikungunya epidemics in the most affected states in Brazil, from 2015 and 2016.<br /><br />Methods: We studied the monthly mortality by age group, comparing a period without epidemics to a chikungunya epidemic period, which we defined arbitrarily as consecutive months with incidences of more than 50 cases/100,000 persons.<br /><br />Results: We obtained official data from the National System of Reported Diseases (SINAN) and the Mortality Information System (SIM), both maintained by the Ministry of Health. We identified a significant increase in the all-cause mortality rate during chikungunya epidemics, while there was no similar mortality in the previous years, even during dengue epidemics. We estimated an excess of 4,505 deaths in Pernambuco during the chikungunya epidemics (47.9 per 100,000 persons).The most affected age groups were the elderly and those under 1 year of age, and the same pattern occurred in all the states.<br /><br />Discussion: Further studies at other sites are needed to confirm the association between increased mortality and chikungunya epidemics indifferent age groups. If these findings are confirmed, it will be necessary to revise the guidelines to recognize the actual mortality associated with chikungunya and to improve therapeutic approaches and protective measures in the most vulnerable groups.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5077abb0fa723c4defe5f75ff1f31bfa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":55128782,"asset_id":35268161,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/55128782/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="35268161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="35268161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 35268161; 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</script> <div class="js-work-strip profile--work_container" data-work-id="30332025"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/30332025/ZikaLab_Manual_T%C3%A9cnico_de_forma%C3%A7%C3%A3o_do_trabalhador_de_sa%C3%BAde_no_contexto_do_V%C3%ADrus_Zika"><img alt="Research paper thumbnail of ZikaLab: Manual Técnico de formação do trabalhador de saúde no contexto do Vírus Zika" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/30332025/ZikaLab_Manual_T%C3%A9cnico_de_forma%C3%A7%C3%A3o_do_trabalhador_de_sa%C3%BAde_no_contexto_do_V%C3%ADrus_Zika">ZikaLab: Manual Técnico de formação do trabalhador de saúde no contexto do Vírus Zika</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/RaquelDoria">Raquel Doria</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30332025"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30332025"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30332025; 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These eggs release larvae (miracidium) that infect freshwater molluscs in which the parasites multiply through asexual reproduction. These molluscs release aquatic larvae (cercariae) that actively penetrate the skin of a new, vertebrate host. These larvae become adults that inhabit inside the veins in the digestive system (S. mansoni and S. japonicum) and of the urinary system (S. haematobium). The geographic distribution of each species is varied and depends on the presence of molluscs capable of serving as hosts (each Schistosoma species has different molluscs as hosts). Precarious sanitary conditions also contribute in the definition of locations where schistosomiasis occurs . Schistosoma mansoni occurs in 74 countries located in Africa, the Middle East, South America and the Caribbean. Its eggs measure about 60 x 140 μm, with lateral spine and are eliminated in the feces, being a main cause of intestinal, hepatosplenic, cardiopulmonary and cerebral diseases, aside from being the main cause of spinal cord schistosomiasis. S. haematobium occurs in Africa and in the Middle East and its eggs measure about 60 x 150 μm, with terminal spine, are eliminated in the urine and on rare occasions in the feces, being the mains cause of urinary diseases and spinal cord schistosomiasis. S. japonicum, S. mekongi and S. malayensis occur in Asia (they are also called S. japonicum-like); eggs measure about 60 x 100 μm, lack spine and are eliminated in the feces, causing hepatic diseases, cerebral neuroschistosomiasis, although there have been rare reports of cases in which spinal cord schistosomiasis was caused by S. japonicum. S. intercalatum occurs in Africa. Eggs are eliminated in the feces. It causes mild intestinal disease but not neuroschistosomiasis, being the least important species, clinically. The presence of spines in the eggs of S. mansoni and S. haematobium might explain why medullar and cerebral neuroschistosomiasis are more common in these species. Spine makes it more difficult for the eggs to travel through the vertebral veins, causing them to be stuck in the lumbar or thoracic spinal cord. S. japonium's eggs, being smaller and lacking spine, migrate more easily to the brain through these veins, crossing the spinal cord without sticking to it. There are, still, species belonging to the Schistosomatidae family (ex: Trichobilharzia regenti) that can cause cercarial dermatitis (or summer's itch) without, however, reaching adult life in men and, therefore, not having any major clinical importance. Parasitic Diseases -Schistosomiasis Spinal Cord Schistosomiasis <a href="http://dx.doi.org/10.5772/53771" rel="nofollow">http://dx.doi.org/10.5772/53771</a> Spinal Cord Schistosomiasis <a href="http://dx.doi.org/10.5772/53771" rel="nofollow">http://dx.doi.org/10.5772/53771</a> Parasitic Diseases -Schistosomiasis 132 Spinal Cord Schistosomiasis</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="706bcd0bf2088b46b090e55eb7cdd677" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45356086,"asset_id":25033626,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45356086/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="25033626"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="25033626"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 25033626; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="10534412"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/10534412/Chikungunya_in_Brazil_an_emerging_challenge"><img alt="Research paper thumbnail of Chikungunya in Brazil: an emerging challenge" class="work-thumbnail" src="https://attachments.academia-assets.com/36525160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/10534412/Chikungunya_in_Brazil_an_emerging_challenge">Chikungunya in Brazil: an emerging challenge</a></div><div class="wp-workCard_item"><span>REV BRAS EPIDEMIOL</span><span>, Jan 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">For the first time in history it was documented an indigenous transmission of Chikungunya fever i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">For the first time in history it was documented an indigenous transmission of Chikungunya fever in the Americas in the Caribbean in 2013. Then it has been confirmed in Oiapoque the occurrence in Brazil. By October 2014, there were 828 cases in the country, only 39 pointed as coming from abroad.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bc75313e7683d83cf33922f11af4a1c7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":36525160,"asset_id":10534412,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/36525160/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="10534412"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="10534412"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 10534412; 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A seguir, foi confirmada, no Oiapoque, <br />a ocorrência no Brasil. Até outubro de 2014, foram registrados 828 casos no país, sendo <br />somente 39 vindos do exterior.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6a170cf50da99d8ceb45b736890be0dc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":36494991,"asset_id":10468003,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/36494991/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="10468003"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="10468003"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 10468003; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3710836"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3710836/Mortality_Associated_with_Influenza_in_Tropics_State_of_S%C3%A3o_Paulo_Brazil_from_2002_to_2011_The_Pre_Pandemic_Pandemic_and_Post_Pandemic_Periods"><img alt="Research paper thumbnail of Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: The Pre-Pandemic, Pandemic, and Post-Pandemic Periods" class="work-thumbnail" src="https://attachments.academia-assets.com/31392820/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3710836/Mortality_Associated_with_Influenza_in_Tropics_State_of_S%C3%A3o_Paulo_Brazil_from_2002_to_2011_The_Pre_Pandemic_Pandemic_and_Post_Pandemic_Periods">Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: The Pre-Pandemic, Pandemic, and Post-Pandemic Periods</a></div><div class="wp-workCard_item"><span>Influenza Research and Treatment</span><span>, Jun 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet completely understood, particularly in tropical and subtropical countries. The trends of influenza related mortality rate in different age groups and different outcomes on a area in tropical and subtropical climate with more than 41 million people (State of São Paulo, Brazil), were studied from 2002 to 2011 were studied. Serfling-type regression analysis was performed using weekly mortality registries and virological data obtained from sentinel surveillance. The prepandemic years presented a well-defined seasonality during winter and a clear relationship between activity of AH3N2 and increase of mortality in all ages, especially in individuals older than 60 years. The mortality due to pneumonia and influenza and respiratory causes associated with 2009 pandemic influenza in the age groups 0-4 years and older than 60 was lower than the previous years. Among people aged 5-19 and 20-59 years the mortality was 2.6 and 4.4 times higher than that in previous periods, respectively. The mortality in all ages was higher than the average of the previous years but was equal mortality in epidemics of AH3N2. The 2009 pandemic influenza mortality showed significant differences compared to other years, especially considering the age groups most affected.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="03032dfdecc14a71f163024929d36315" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31392820,"asset_id":3710836,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31392820/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3710836"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3710836"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3710836; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3710836]").text(description); $(".js-view-count[data-work-id=3710836]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3710836; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3710836']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "03032dfdecc14a71f163024929d36315" } } $('.js-work-strip[data-work-id=3710836]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3710836,"title":"Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: The Pre-Pandemic, Pandemic, and Post-Pandemic Periods","translated_title":"","metadata":{"ai_title_tag":"Influenza Mortality Trends in São Paulo, 2002-2011","grobid_abstract":"The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet completely understood, particularly in tropical and subtropical countries. The trends of influenza related mortality rate in different age groups and different outcomes on a area in tropical and subtropical climate with more than 41 million people (State of São Paulo, Brazil), were studied from 2002 to 2011 were studied. Serfling-type regression analysis was performed using weekly mortality registries and virological data obtained from sentinel surveillance. The prepandemic years presented a well-defined seasonality during winter and a clear relationship between activity of AH3N2 and increase of mortality in all ages, especially in individuals older than 60 years. The mortality due to pneumonia and influenza and respiratory causes associated with 2009 pandemic influenza in the age groups 0-4 years and older than 60 was lower than the previous years. Among people aged 5-19 and 20-59 years the mortality was 2.6 and 4.4 times higher than that in previous periods, respectively. 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Efeito da temperatura e umidade na transmissão de dengue e avaliação dos mecanismos de controle" class="work-thumbnail" src="https://attachments.academia-assets.com/31105020/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3250409/Efeito_da_temperatura_e_umidade_na_transmiss%C3%A3o_de_dengue_e_avalia%C3%A7%C3%A3o_dos_mecanismos_de_controle">Efeito da temperatura e umidade na transmissão de dengue e avaliação dos mecanismos de controle</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Temperatura e umidade influenciam fortemente a infestação de mosquitos. Porém a influência abióti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Temperatura e umidade influenciam fortemente a infestação de mosquitos. Porém a influência abiótica é suavizada na propagação de dengue. Há extremos de temperaturas, abaixo e acima das quais não há transmissão de dengue, mesmo que seja possível infestação por mosquitos. Os dados encontrados sugerem a necessidade de acompanhamento dos dados pluviométricos , de vigilância epidemiológica e sorotipos circulantes, pois podem colaborar bastante na elaboração de ações preventivas à dengue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6aafc84491888db062c896ed3950412f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31105020,"asset_id":3250409,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31105020/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3250409"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3250409"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3250409; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2347379"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2347379/Hematological_and_clinical_evaluation_of_345_acute_dengue_3_infections_patientes_during_2002_outbreak_in_Campinas_SP_Brazil"><img alt="Research paper thumbnail of Hematological and clinical evaluation of 345 acute dengue-3 infections patientes during 2002 outbreak in Campinas -SP - Brazil " class="work-thumbnail" src="https://attachments.academia-assets.com/30388777/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2347379/Hematological_and_clinical_evaluation_of_345_acute_dengue_3_infections_patientes_during_2002_outbreak_in_Campinas_SP_Brazil">Hematological and clinical evaluation of 345 acute dengue-3 infections patientes during 2002 outbreak in Campinas -SP - Brazil </a></div><div class="wp-workCard_item"><span>Virus Reviews and Research</span><span>, Jul 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">"Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients durin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">"Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil <br />Introduction: Dengue is the most important mosquito-borne viral disease. Hematological impact of DV infection has been described and the exact mechanism leading to the changes are not well understood yet. In the present study, clinical-hematological data obtained prospectively during 2002 outbreak in Campinas-SP-Brazil were analyzed. Methodology: Out and in-patients in a community were evaluated by the same group of physicians using a standard protocol. Overall, 345 patients were enrolled in the study: male 152(44.1%), female 193(55.9%); age range 9 months-75 years(median 28y); 55(15.9%) children, 290(84.1%) adults; 334(96.8%) cases were classified as Dengue Fever(DF), 9(2.6%) as Dengue Hemorrhagic Fever(DHF) and 2(0.6%) cases as Dengue Shock Syndrome(DSS) according to WHO criteria. All patients had DV infection confirmed by serology, performed by the public regional reference laboratory. Whole blood samples obtained from the patients were analyzed by automatic cell counter(Celldyn1400). Results: All patient presented with fever, 80.9% presented headache, 74.5% myalgia, 66.4% fatigue, 64.1% anorexia, 40.1% positive tourniquet test, 24.2% skin rashes. Bleeding symptoms were present in 10.7% of patients: epistaxis in 3.5%, gingival bleeding in 2.9%, melena in 2.0% and others like gynecological bleeding hematemesis and bleeding at venipuncture site. In 20 cases, it was not possible to obtain blood sample to perform the hemograme. Hematological changes found were thrombocytopenia(platelets<150x109/L) in 53.9% of cases(including all DHF/DSS cases) with mean nadir occurring in the 6th day after initial symptoms, leucopenia(leucocytes<3.5x106/L) in 52.8% of patients with mean nadir in the 4th day. The presence of thrombocytopenia was more frequent in leucopenic patients(OR=4.63, 2.67<OR<8.04, P<0.000001, 2=34.09). In 42 cases of DF(12.1%) serial hemogrames(3) were available. In these cases, mean of highest hematocrit occurred in the 5th day reaching 43.4% with a mean increase of 11.6%. Discussion: The results of the present study reinforce that DV infection have important impact on hematological parameter of patients. Moreover, the increase of hematocrit on 5th day after initial symptoms, suggests that hemoconcentration may also occur on DF cases although in a lesser extent than in DHF/DSS. The presence of earlier leucopenia suggests also a 4-fold higher risk of development of thrombocytopenia. The mechanisms leading to these findings must be better explored. <br /> <br />Abstract/Author(s) Details <br />-------------------------- <br />TITLE: Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil <br /> <br />AUTHORS: André Ricardo Ribas Freitas, Nicole Montenegro Medeiros Coelho, Brigina Kemp, Rodrigo Nogueira Angerami, Fernanda Loureiro Orsi,  Luiz Jacintho da Silva, Vagner Castro <br />DEPT: Coordenadoria de Vigilância em Saúde - Secretaria Municipal de Saúde; Faculdade de Ciências Médicas <br />INST: Prefeitura Municipal de Campinas - Campinas  - SP - Brazil; Universidade Estadual de Campinas - UNICAMP</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="19d4ca03b1d347c60678b85311679c3f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":30388777,"asset_id":2347379,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/30388777/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2347379"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2347379"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2347379; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=2347379]").text(description); $(".js-view-count[data-work-id=2347379]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 2347379; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='2347379']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "19d4ca03b1d347c60678b85311679c3f" } } $('.js-work-strip[data-work-id=2347379]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":2347379,"title":"Hematological and clinical evaluation of 345 acute dengue-3 infections patientes during 2002 outbreak in Campinas -SP - Brazil ","translated_title":"","metadata":{"abstract":"\"Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\nIntroduction: Dengue is the most important mosquito-borne viral disease. Hematological impact of DV infection has been described and the exact mechanism leading to the changes are not well understood yet. In the present study, clinical-hematological data obtained prospectively during 2002 outbreak in Campinas-SP-Brazil were analyzed. Methodology: Out and in-patients in a community were evaluated by the same group of physicians using a standard protocol. Overall, 345 patients were enrolled in the study: male 152(44.1%), female 193(55.9%); age range 9 months-75 years(median 28y); 55(15.9%) children, 290(84.1%) adults; 334(96.8%) cases were classified as Dengue Fever(DF), 9(2.6%) as Dengue Hemorrhagic Fever(DHF) and 2(0.6%) cases as Dengue Shock Syndrome(DSS) according to WHO criteria. All patients had DV infection confirmed by serology, performed by the public regional reference laboratory. Whole blood samples obtained from the patients were analyzed by automatic cell counter(Celldyn1400). Results: All patient presented with fever, 80.9% presented headache, 74.5% myalgia, 66.4% fatigue, 64.1% anorexia, 40.1% positive tourniquet test, 24.2% skin rashes. Bleeding symptoms were present in 10.7% of patients: epistaxis in 3.5%, gingival bleeding in 2.9%, melena in 2.0% and others like gynecological bleeding hematemesis and bleeding at venipuncture site. In 20 cases, it was not possible to obtain blood sample to perform the hemograme. Hematological changes found were thrombocytopenia(platelets\u003c150x109/L) in 53.9% of cases(including all DHF/DSS cases) with mean nadir occurring in the 6th day after initial symptoms, leucopenia(leucocytes\u003c3.5x106/L) in 52.8% of patients with mean nadir in the 4th day. The presence of thrombocytopenia was more frequent in leucopenic patients(OR=4.63, 2.67\u003cOR\u003c8.04, P\u003c0.000001, 2=34.09). In 42 cases of DF(12.1%) serial hemogrames(3) were available. In these cases, mean of highest hematocrit occurred in the 5th day reaching 43.4% with a mean increase of 11.6%. Discussion: The results of the present study reinforce that DV infection have important impact on hematological parameter of patients. Moreover, the increase of hematocrit on 5th day after initial symptoms, suggests that hemoconcentration may also occur on DF cases although in a lesser extent than in DHF/DSS. The presence of earlier leucopenia suggests also a 4-fold higher risk of development of thrombocytopenia. The mechanisms leading to these findings must be better explored.\r\n\r\nAbstract/Author(s) Details\r\n--------------------------\r\nTITLE: Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\n \r\nAUTHORS: André Ricardo Ribas Freitas, Nicole Montenegro Medeiros Coelho, Brigina Kemp, Rodrigo Nogueira Angerami, Fernanda Loureiro Orsi, Luiz Jacintho da Silva, Vagner Castro \r\nDEPT: Coordenadoria de Vigilância em Saúde - Secretaria Municipal de Saúde; Faculdade de Ciências Médicas \r\nINST: Prefeitura Municipal de Campinas - Campinas - SP - Brazil; Universidade Estadual de Campinas - UNICAMP ","publication_date":{"day":null,"month":7,"year":2008,"errors":{}},"publication_name":"Virus Reviews and Research"},"translated_abstract":"\"Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\nIntroduction: Dengue is the most important mosquito-borne viral disease. Hematological impact of DV infection has been described and the exact mechanism leading to the changes are not well understood yet. In the present study, clinical-hematological data obtained prospectively during 2002 outbreak in Campinas-SP-Brazil were analyzed. Methodology: Out and in-patients in a community were evaluated by the same group of physicians using a standard protocol. Overall, 345 patients were enrolled in the study: male 152(44.1%), female 193(55.9%); age range 9 months-75 years(median 28y); 55(15.9%) children, 290(84.1%) adults; 334(96.8%) cases were classified as Dengue Fever(DF), 9(2.6%) as Dengue Hemorrhagic Fever(DHF) and 2(0.6%) cases as Dengue Shock Syndrome(DSS) according to WHO criteria. All patients had DV infection confirmed by serology, performed by the public regional reference laboratory. Whole blood samples obtained from the patients were analyzed by automatic cell counter(Celldyn1400). Results: All patient presented with fever, 80.9% presented headache, 74.5% myalgia, 66.4% fatigue, 64.1% anorexia, 40.1% positive tourniquet test, 24.2% skin rashes. Bleeding symptoms were present in 10.7% of patients: epistaxis in 3.5%, gingival bleeding in 2.9%, melena in 2.0% and others like gynecological bleeding hematemesis and bleeding at venipuncture site. In 20 cases, it was not possible to obtain blood sample to perform the hemograme. Hematological changes found were thrombocytopenia(platelets\u003c150x109/L) in 53.9% of cases(including all DHF/DSS cases) with mean nadir occurring in the 6th day after initial symptoms, leucopenia(leucocytes\u003c3.5x106/L) in 52.8% of patients with mean nadir in the 4th day. The presence of thrombocytopenia was more frequent in leucopenic patients(OR=4.63, 2.67\u003cOR\u003c8.04, P\u003c0.000001, 2=34.09). In 42 cases of DF(12.1%) serial hemogrames(3) were available. 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Hematological impact of DV infection has been described and the exact mechanism leading to the changes are not well understood yet. In the present study, clinical-hematological data obtained prospectively during 2002 outbreak in Campinas-SP-Brazil were analyzed. Methodology: Out and in-patients in a community were evaluated by the same group of physicians using a standard protocol. Overall, 345 patients were enrolled in the study: male 152(44.1%), female 193(55.9%); age range 9 months-75 years(median 28y); 55(15.9%) children, 290(84.1%) adults; 334(96.8%) cases were classified as Dengue Fever(DF), 9(2.6%) as Dengue Hemorrhagic Fever(DHF) and 2(0.6%) cases as Dengue Shock Syndrome(DSS) according to WHO criteria. All patients had DV infection confirmed by serology, performed by the public regional reference laboratory. Whole blood samples obtained from the patients were analyzed by automatic cell counter(Celldyn1400). Results: All patient presented with fever, 80.9% presented headache, 74.5% myalgia, 66.4% fatigue, 64.1% anorexia, 40.1% positive tourniquet test, 24.2% skin rashes. Bleeding symptoms were present in 10.7% of patients: epistaxis in 3.5%, gingival bleeding in 2.9%, melena in 2.0% and others like gynecological bleeding hematemesis and bleeding at venipuncture site. In 20 cases, it was not possible to obtain blood sample to perform the hemograme. Hematological changes found were thrombocytopenia(platelets\u003c150x109/L) in 53.9% of cases(including all DHF/DSS cases) with mean nadir occurring in the 6th day after initial symptoms, leucopenia(leucocytes\u003c3.5x106/L) in 52.8% of patients with mean nadir in the 4th day. The presence of thrombocytopenia was more frequent in leucopenic patients(OR=4.63, 2.67\u003cOR\u003c8.04, P\u003c0.000001, 2=34.09). In 42 cases of DF(12.1%) serial hemogrames(3) were available. In these cases, mean of highest hematocrit occurred in the 5th day reaching 43.4% with a mean increase of 11.6%. Discussion: The results of the present study reinforce that DV infection have important impact on hematological parameter of patients. Moreover, the increase of hematocrit on 5th day after initial symptoms, suggests that hemoconcentration may also occur on DF cases although in a lesser extent than in DHF/DSS. The presence of earlier leucopenia suggests also a 4-fold higher risk of development of thrombocytopenia. The mechanisms leading to these findings must be better explored.\r\n\r\nAbstract/Author(s) Details\r\n--------------------------\r\nTITLE: Hematological and clinical evaluation of a cohort of 345 acute Dengue-3 infection patients during 2002 outbreak in Campinas - SP - Brazil\r\n \r\nAUTHORS: André Ricardo Ribas Freitas, Nicole Montenegro Medeiros Coelho, Brigina Kemp, Rodrigo Nogueira Angerami, Fernanda Loureiro Orsi, Luiz Jacintho da Silva, Vagner Castro \r\nDEPT: Coordenadoria de Vigilância em Saúde - Secretaria Municipal de Saúde; Faculdade de Ciências Médicas \r\nINST: Prefeitura Municipal de Campinas - Campinas - SP - Brazil; Universidade Estadual de Campinas - UNICAMP ","owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas Freitas","url":"https://slmandic.academia.edu/AndreRicardoRibasFreitas"},"attachments":[{"id":30388777,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/30388777/thumbnails/1.jpg","file_name":"Dengue_Hemograma_PanAmericano_Recife_2008.pdf","download_url":"https://www.academia.edu/attachments/30388777/download_file","bulk_download_file_name":"Hematological_and_clinical_evaluation_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/30388777/Dengue_Hemograma_PanAmericano_Recife_2008-libre.pdf?1390886399=\u0026response-content-disposition=attachment%3B+filename%3DHematological_and_clinical_evaluation_of.pdf\u0026Expires=1738614856\u0026Signature=ZLUhvovoJzYXOSCNXiAnIfj9K8Pt2saZ4KK42VDt7ncGnveTRoegDKN7TegFdrinWDSf6YbRuBnfe1PhYgZXBsbrFBc2Ig3~CzsGxB2IeauSrZI9VpioPRgdlHgt-XRTHtuvGmNCkMgN-Q1xLeAL8KooiFVIWbM77Sa7UtX7qJkXTmP1KNEYRJihXt6OZ410hWBrDOSXs3fpyhujZt-A86QMMjrRKj-aVWRtyVePsE7PRuT3jw0J6YoIaRdj6~lEwfJK-GW4f8~gzq2AfpfMJTqH12Jz3KIYh2MGOndXaws3VRVydr3LTATADv5gM1fA2zEiPw3ck7GVCzvki7aViA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology"},{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology"},{"id":7823,"name":"Malaria","url":"https://www.academia.edu/Documents/in/Malaria"},{"id":8241,"name":"Tropical Medicine","url":"https://www.academia.edu/Documents/in/Tropical_Medicine"},{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":22844,"name":"Insect Molecular Biology","url":"https://www.academia.edu/Documents/in/Insect_Molecular_Biology"},{"id":24882,"name":"Medical Entomology","url":"https://www.academia.edu/Documents/in/Medical_Entomology"},{"id":157268,"name":"Dengue","url":"https://www.academia.edu/Documents/in/Dengue"},{"id":1115412,"name":"Vector Biology \u0026 Control","url":"https://www.academia.edu/Documents/in/Vector_Biology_and_Control-1"},{"id":1115413,"name":"Biochemical Entomology","url":"https://www.academia.edu/Documents/in/Biochemical_Entomology"}],"urls":[{"id":435560,"url":"http://www.virusreviewsandresearch.com/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2157529"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2157529/Co_infection_between_the_pandemic_influenza_virus_A_H1N1_and_seasonal_influenza_A_virus_in_a_patient_presenting_severe_acute_respiratory_disease"><img alt="Research paper thumbnail of Co-infection between the pandemic influenza virus A H1N1 and seasonal influenza A virus in a patient presenting severe acute respiratory disease" class="work-thumbnail" src="https://attachments.academia-assets.com/30212517/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2157529/Co_infection_between_the_pandemic_influenza_virus_A_H1N1_and_seasonal_influenza_A_virus_in_a_patient_presenting_severe_acute_respiratory_disease">Co-infection between the pandemic influenza virus A H1N1 and seasonal influenza A virus in a patient presenting severe acute respiratory disease</a></div><div class="wp-workCard_item"><span>International Journal of Infectious Diseases</span><span>, Mar 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstracts e103 members, were followed up with home visits to determine secondary infections in th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstracts e103 members, were followed up with home visits to determine secondary infections in the household. Serum samples taken at baseline and convalescence were tested for HAI specific to pandemic H1N1, seasonal H1N1 and seasonal H3N2. 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A review of ofﬁcial reports and the scientiﬁc literature" class="work-thumbnail" src="https://attachments.academia-assets.com/29558776/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2040239/Clusters_of_Brazilian_spotted_fever_in_Sa_o_Paulo_State_southeastern_Brazil_A_review_of_official_reports_and_the_scientific_literature">Clusters of Brazilian spotted fever in Sa˜o Paulo State, southeastern Brazil. A review of ofﬁcial reports and the scientiﬁc literature</a></div><div class="wp-workCard_item"><span>Clinical Microbiology and Infectious Diseases</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c71561d1f7e54fff2b41f8fccfcc32eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":29558776,"asset_id":2040239,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/29558776/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="2040239"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="2040239"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2040239; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=2040239]").text(description); $(".js-view-count[data-work-id=2040239]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 2040239; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='2040239']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c71561d1f7e54fff2b41f8fccfcc32eb" } } $('.js-work-strip[data-work-id=2040239]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":2040239,"title":"Clusters of Brazilian spotted fever in Sa˜o Paulo State, southeastern Brazil. 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Os resultados dos testes para os 43 casos restantes estão pendentes. O rastreamento de contatos para os casos confirmados está em andamento. O Ministério da Saúde identificou 1.124 contatos próximos. Dos 1.021 que ainda estão em Cingapura, 989 foram contatados e estão em quarentena ou isolados. 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Transmission cycles, host range, evolution and emergence of arbov...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Weaver SC and Barrett ADT 2004. Transmission cycles, host range, evolution and emergence of arboviral disease. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3347393"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3347393/Preocupa%C3%A7%C3%B5es_com_o_novo_virus_de_influenza_avi%C3%A1ria_AH7N9_2013"><img alt="Research paper thumbnail of Preocupações com o novo virus de influenza aviária AH7N9 2013" class="work-thumbnail" src="https://attachments.academia-assets.com/31161609/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3347393/Preocupa%C3%A7%C3%B5es_com_o_novo_virus_de_influenza_avi%C3%A1ria_AH7N9_2013">Preocupações com o novo virus de influenza aviária AH7N9 2013</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">O surto de influenza com casos humanos e aviários causados pelo novo virus AH7N9 traz muitas preo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">O surto de influenza com casos humanos e aviários causados pelo novo virus AH7N9 traz muitas preocupações, destaco algumas informações que considerei relevante, elas foram extraídas da literatura apresentada ao final:</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1c1a0c3747b6f1f324f85ae7f45c4e86" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31161609,"asset_id":3347393,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31161609/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3347393"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3347393"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3347393; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="2347298"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/2347298/Informe_T%C3%A9cnico_2009_Esquistossomose_Mans%C3%B4nica_Centro_de_Vigil%C3%A2ncia_Epidemiol%C3%B3gica_Est_S%C3%A3o_Paulo_"><img alt="Research paper thumbnail of Informe Técnico 2009: Esquistossomose Mansônica (Centro de Vigilância Epidemiológica - Est São Paulo)" class="work-thumbnail" src="https://attachments.academia-assets.com/30388689/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/2347298/Informe_T%C3%A9cnico_2009_Esquistossomose_Mans%C3%B4nica_Centro_de_Vigil%C3%A2ncia_Epidemiol%C3%B3gica_Est_S%C3%A3o_Paulo_">Informe Técnico 2009: Esquistossomose Mansônica (Centro de Vigilância Epidemiológica - Est São Paulo)</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A esquistossomose mansônica (CID 10ª Rev. B65.9), também conhecida como "xistose", "xistosa", "xi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A esquistossomose mansônica (CID 10ª Rev. 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</script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="1327376" id="videos"><div class="js-work-strip profile--work_container" data-work-id="39332051"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/39332051/Manejo_Cl%C3%ADnico_do_Paciente_com_Suspeita_de_Dengue"><img alt="Research paper thumbnail of Manejo Clínico do Paciente com Suspeita de Dengue" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/39332051/Manejo_Cl%C3%ADnico_do_Paciente_com_Suspeita_de_Dengue">Manejo Clínico do Paciente com Suspeita de Dengue</a></div><div class="wp-workCard_item"><span>Manejo Clínico do Paciente com Suspeita de Dengue</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Trata-se de um vídeo para suporte técnico aos profissionais que trabalham no atendimento aos paci...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Trata-se de um vídeo para suporte técnico aos profissionais que trabalham no atendimento aos pacientes com suspeita de dengue, com ênfase às situações de epidemia.<br />Produzido pelo CONASEMS dentro do Projeto Aedes na Mira.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="39332051"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="39332051"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 39332051; 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Aula Organização da Assistência ao Paciente com Dengue em Situações de Epidemia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/11441511/_Aula_Organiza%C3%A7%C3%A3o_da_Assist%C3%AAncia_ao_Paciente_com_Dengue_em_Situa%C3%A7%C3%B5es_de_Epidemia"> ... 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Aula Organização da Assistência ao Paciente com Dengue em Situações de Epidemia","internal_url":"https://www.academia.edu/11441511/_Aula_Organiza%C3%A7%C3%A3o_da_Assist%C3%AAncia_ao_Paciente_com_Dengue_em_Situa%C3%A7%C3%B5es_de_Epidemia","owner_id":1832802,"coauthors_can_edit":true,"owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas Freitas","url":"https://slmandic.academia.edu/AndreRicardoRibasFreitas"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="6688679"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/6688679/Orienta%C3%A7%C3%B5es_para_o_paciente_com_Dengue_p%C3%BAblico_em_geral_"><img alt="Research paper thumbnail of Orientações para o paciente com Dengue (público em geral)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/6688679/Orienta%C3%A7%C3%B5es_para_o_paciente_com_Dengue_p%C3%BAblico_em_geral_">Orientações para o paciente com Dengue (público em geral)</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="6688679"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="6688679"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 6688679; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=6688679]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":6688679,"title":"Orientações para o paciente com Dengue (público em geral)","internal_url":"https://www.academia.edu/6688679/Orienta%C3%A7%C3%B5es_para_o_paciente_com_Dengue_p%C3%BAblico_em_geral_","owner_id":1832802,"coauthors_can_edit":true,"owner":{"id":1832802,"first_name":"André Ricardo","middle_initials":null,"last_name":"Ribas Freitas","page_name":"AndreRicardoRibasFreitas","domain_name":"slmandic","created_at":"2012-05-27T13:18:50.963-07:00","display_name":"André Ricardo Ribas Freitas","url":"https://slmandic.academia.edu/AndreRicardoRibasFreitas"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="7788406" id="drafts"><div class="js-work-strip profile--work_container" data-work-id="35382414"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/35382414/Excess_deaths_associated_with_the_chikungunya_epidemic_of_2014_in_Jamaica_were_higher_among_children_under_5_and_over_40_years_of_age_an_analysis_based_on_official_data"><img alt="Research paper thumbnail of Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among children under 5 and over 40 years of age, an analysis based on official data" class="work-thumbnail" src="https://attachments.academia-assets.com/55242164/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/35382414/Excess_deaths_associated_with_the_chikungunya_epidemic_of_2014_in_Jamaica_were_higher_among_children_under_5_and_over_40_years_of_age_an_analysis_based_on_official_data">Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among children under 5 and over 40 years of age, an analysis based on official data</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among child...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among children under 5 and over 40 years of age, an analysis based on official data. Running title: Mortality associated chikungunya Jamaica Title: Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among children under 5 and over 40 years of age, an analysis based on official data. Abstract: We assessed the excess of all causes of mortality by age groups during the chikungunya epidemics in Jamaica, 2014. Excess mortality was estimated by subtracting deaths observed in 2014 from that expected based on the average mortality rate of 2012-2013, with confidence interval of 99%. Overall mortality 91.9 / 100,000 population, 2,499 additional deaths than expected coincided with the peak of the epidemic, there was a strong correlation between the monthly incidence and the excess of deaths (Spearman Rho = 0.939; p <0.005). The excess mortality found in Jamaica was 2499 deaths, more than 10 times the total deaths reported by all the countries of the Americas in the year 2014 for PAHO. No other significant epidemiological phenomenon occurred on that island that could explain this increase in mortality. Thus, we suggest that mortality associated with chikungunya is underestimated in Jamaica, as in other countries. The excess of deaths could be a strategic tool for the epidemiological surveillance of chikungunya as it has already been used in influenza and respiratory syncytial.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b3d32850ddeb000843ecf2088b0c9693" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":55242164,"asset_id":35382414,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/55242164/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="35382414"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="35382414"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 35382414; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="35382389"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/35382389/Bio_Rxiv_Excess_mortality_in_Guadeloupe_and_Martinique_during_the_chikungunya_epidemic_of_2014"><img alt="Research paper thumbnail of Bio Rxiv Excess mortality in Guadeloupe and Martinique during the chikungunya epidemic of 2014" class="work-thumbnail" src="https://attachments.academia-assets.com/55242137/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/35382389/Bio_Rxiv_Excess_mortality_in_Guadeloupe_and_Martinique_during_the_chikungunya_epidemic_of_2014">Bio Rxiv Excess mortality in Guadeloupe and Martinique during the chikungunya epidemic of 2014</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://slmandic.academia.edu/AndreRicardoRibasFreitas">André Ricardo Ribas Freitas</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MariaRitaDonalisio">Maria Rita Donalisio</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In some chikugunya epidemics, deaths are not fully captured by the traditional surveillance syste...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In some chikugunya epidemics, deaths are not fully captured by the traditional surveillance system, based on case reports and death reports. This is a time series study to evaluate the excess of mortality associated with epidemic of chikungunya virus (CHIKV) in Guadeloupe and Martinique, Antilles, 2014. The population (total 784,097 inhabitants) and mortality data estimated by sex and age were accessed at the Institut National de la Statistique et des Études Économiques - France. Age adjusted mortality rates were calculated also in Réunion, Indian Ocean for comparison. Epidemiological data on CHIKV (cases, hospitalizations, and deaths) were obtained in the official epidemiological reports of the Cellule de Institut de Veille Sanitaire –France. The excess of deaths for each month in 2014 and 2015 was the difference between the expected and observed deaths for all age groups, considering the 99% confidence interval threshold. Pearson coefficient of correlation between monthly excess of deaths and reported cases of chikungunya show a strong correlation (R = 0.81, p <0.005), also with a 1-month lag (R = 0.87, p <0.001), and between monthly rates of hospitalization for CHIKV and the excess of deaths with a delay of 1 month (R = 0.87, p <0.0005).The peak of the epidemic occurred in the month with the highest mortality, returning to normal soon after the end of the CHIKV epidemic. The overall mortality estimated by this method (639 deaths) was about 4 times greater than that obtained through death certificate (160 deaths). Excess mortality increased with age. Although etiological diagnosis of all deaths associated with CHIKV infection is not possible, already well-known statistical tools can contribute to an evaluation of the impact of this virus on the mortality and morbidity in the different age groups.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9df08c37f478057edfbdc32bbc0f3281" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":55242137,"asset_id":35382389,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/55242137/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="35382389"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="35382389"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 35382389; 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