Journal of Clinical Medicine | An Open Access Journal from MDPI

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value="cosmetics" > Cosmetics </option> <option value="covid" > COVID </option> <option value="crops" > Crops </option> <option value="cryo" > Cryo </option> <option value="cryptography" > Cryptography </option> <option value="crystals" > Crystals </option> <option value="cimb" > Current Issues in Molecular Biology (CIMB) </option> <option value="curroncol" > Current Oncology </option> <option value="dairy" > Dairy </option> <option value="data" > Data </option> <option value="dentistry" > Dentistry Journal </option> <option value="dermato" > Dermato </option> <option value="dermatopathology" > Dermatopathology </option> <option value="designs" > Designs </option> <option value="diabetology" > Diabetology </option> <option value="diagnostics" > Diagnostics </option> <option value="dietetics" > Dietetics </option> <option value="digital" > Digital </option> <option value="disabilities" > Disabilities </option> <option value="diseases" > Diseases </option> <option value="diversity" > 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value="engproc" > Engineering Proceedings </option> <option value="entropy" > Entropy </option> <option value="environsciproc" > Environmental Sciences Proceedings </option> <option value="environments" > Environments </option> <option value="epidemiologia" > Epidemiologia </option> <option value="epigenomes" > Epigenomes </option> <option value="ebj" > European Burn Journal (EBJ) </option> <option value="ejihpe" > European Journal of Investigation in Health, Psychology and Education (EJIHPE) </option> <option value="fermentation" > Fermentation </option> <option value="fibers" > Fibers </option> <option value="fintech" > FinTech </option> <option value="fire" > Fire </option> <option value="fishes" > Fishes </option> <option value="fluids" > Fluids </option> <option value="foods" > Foods </option> <option value="forecasting" > Forecasting </option> <option value="forensicsci" > Forensic Sciences </option> <option value="forests" > Forests </option> <option value="fossstud" > Fossil 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</option> <option value="geometry" > Geometry </option> <option value="geosciences" > Geosciences </option> <option value="geotechnics" > Geotechnics </option> <option value="geriatrics" > Geriatrics </option> <option value="glacies" > Glacies </option> <option value="gucdd" > Gout, Urate, and Crystal Deposition Disease (GUCDD) </option> <option value="grasses" > Grasses </option> <option value="hardware" > Hardware </option> <option value="healthcare" > Healthcare </option> <option value="hearts" > Hearts </option> <option value="hemato" > Hemato </option> <option value="hematolrep" > Hematology Reports </option> <option value="heritage" > Heritage </option> <option value="histories" > Histories </option> <option value="horticulturae" > Horticulturae </option> <option value="hospitals" > Hospitals </option> <option value="humanities" > Humanities </option> <option value="humans" > Humans </option> <option value="hydrobiology" > Hydrobiology </option> <option value="hydrogen" > Hydrogen </option> <option value="hydrology" > Hydrology </option> <option value="hygiene" > Hygiene </option> <option value="immuno" > Immuno </option> <option value="idr" > Infectious Disease Reports </option> <option value="informatics" > Informatics </option> <option value="information" > Information </option> <option value="infrastructures" > Infrastructures </option> <option value="inorganics" > Inorganics </option> <option value="insects" > Insects </option> <option value="instruments" > Instruments </option> <option value="iic" > Intelligent Infrastructure and Construction </option> <option value="ijerph" > International Journal of Environmental Research and Public Health (IJERPH) </option> <option value="ijfs" > International Journal of Financial Studies (IJFS) </option> <option value="ijms" > International Journal of Molecular Sciences (IJMS) </option> <option value="IJNS" > International Journal of Neonatal Screening (IJNS) </option> <option value="ijpb" > International Journal of Plant Biology (IJPB) </option> <option value="ijt" > International Journal of Topology </option> <option value="ijtm" > International Journal of Translational Medicine (IJTM) </option> <option value="ijtpp" > International Journal of Turbomachinery, Propulsion and Power (IJTPP) </option> <option value="ime" > International Medical Education (IME) </option> <option value="inventions" > Inventions </option> <option value="IoT" > IoT </option> <option value="ijgi" > ISPRS International Journal of Geo-Information (IJGI) </option> <option value="J" > J </option> <option value="jal" > Journal of Ageing and Longevity (JAL) </option> <option value="jcdd" > Journal of Cardiovascular Development and Disease (JCDD) </option> <option value="jcto" > Journal of Clinical & Translational Ophthalmology (JCTO) </option> <option value="jcm" selected='selected'> Journal of Clinical Medicine (JCM) </option> <option value="jcs" > Journal of Composites Science (J. Compos. Sci.) </option> <option value="jcp" > Journal of Cybersecurity and Privacy (JCP) </option> <option value="jdad" > Journal of Dementia and Alzheimer's Disease (JDAD) </option> <option value="jdb" > Journal of Developmental Biology (JDB) </option> <option value="jeta" > Journal of Experimental and Theoretical Analyses (JETA) </option> <option value="jfb" > Journal of Functional Biomaterials (JFB) </option> <option value="jfmk" > Journal of Functional Morphology and Kinesiology (JFMK) </option> <option value="jof" > Journal of Fungi (JoF) </option> <option value="jimaging" > Journal of Imaging (J. Imaging) </option> <option value="jintelligence" > Journal of Intelligence (J. Intell.) </option> <option value="jlpea" > Journal of Low Power Electronics and Applications (JLPEA) </option> <option value="jmmp" > Journal of Manufacturing and Materials Processing (JMMP) </option> <option value="jmse" > Journal of Marine Science and Engineering (JMSE) </option> <option value="jmahp" > Journal of Market Access & Health Policy (JMAHP) </option> <option value="jmp" > Journal of Molecular Pathology (JMP) </option> <option value="jnt" > Journal of Nanotheranostics (JNT) </option> <option value="jne" > Journal of Nuclear Engineering (JNE) </option> <option value="ohbm" > Journal of Otorhinolaryngology, Hearing and Balance Medicine (JOHBM) </option> <option value="jop" > Journal of Parks </option> <option value="jpm" > Journal of Personalized Medicine (JPM) </option> <option value="jpbi" > Journal of Pharmaceutical and BioTech Industry (JPBI) </option> <option value="jor" > Journal of Respiration (JoR) </option> <option value="jrfm" > Journal of Risk and Financial Management (JRFM) </option> <option value="jsan" > Journal of Sensor and Actuator Networks (JSAN) </option> <option value="joma" > Journal of the Oman Medical Association (JOMA) </option> <option value="jtaer" > Journal of Theoretical and Applied Electronic Commerce Research (JTAER) </option> <option value="jvd" > Journal of Vascular Diseases (JVD) </option> <option value="jox" > Journal of Xenobiotics (JoX) </option> <option value="jzbg" > Journal of Zoological and Botanical Gardens (JZBG) </option> <option value="journalmedia" > Journalism and Media </option> <option value="kidneydial" > Kidney and Dialysis </option> <option value="kinasesphosphatases" > Kinases and Phosphatases </option> <option value="knowledge" > Knowledge </option> <option value="labmed" > LabMed </option> <option value="laboratories" > Laboratories </option> <option value="land" > Land </option> <option value="languages" > Languages </option> <option value="laws" > Laws </option> <option value="life" > Life 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Mathematics </option> <option value="medsci" > Medical Sciences </option> <option value="msf" > Medical Sciences Forum </option> <option value="medicina" > Medicina </option> <option value="medicines" > Medicines </option> <option value="membranes" > Membranes </option> <option value="merits" > Merits </option> <option value="metabolites" > Metabolites </option> <option value="metals" > Metals </option> <option value="meteorology" > Meteorology </option> <option value="methane" > Methane </option> <option value="mps" > Methods and Protocols (MPs) </option> <option value="metrics" > Metrics </option> <option value="metrology" > Metrology </option> <option value="micro" > Micro </option> <option value="microbiolres" > Microbiology Research </option> <option value="micromachines" > Micromachines </option> <option value="microorganisms" > Microorganisms </option> <option value="microplastics" > Microplastics </option> <option value="minerals" > Minerals </option> <option value="mining" > Mining </option> <option value="modelling" > Modelling </option> <option value="mmphys" > Modern Mathematical Physics </option> <option value="molbank" > Molbank </option> <option value="molecules" > Molecules </option> <option value="mti" > Multimodal Technologies and Interaction (MTI) </option> <option value="muscles" > Muscles </option> <option value="nanoenergyadv" > Nanoenergy Advances </option> <option value="nanomanufacturing" > Nanomanufacturing </option> <option value="nanomaterials" > Nanomaterials </option> <option value="ndt" > NDT </option> <option value="network" > Network </option> <option value="neuroglia" > Neuroglia </option> <option value="neurolint" > Neurology International </option> <option value="neurosci" > NeuroSci </option> <option value="nitrogen" > Nitrogen </option> <option value="ncrna" > Non-Coding RNA (ncRNA) </option> <option value="nursrep" > Nursing Reports </option> <option value="nutraceuticals" > Nutraceuticals </option> <option value="nutrients" > Nutrients </option> <option value="obesities" > Obesities </option> <option value="oceans" > Oceans </option> <option value="onco" > Onco </option> <option value="optics" > Optics </option> <option value="oral" > Oral </option> <option value="organics" > Organics </option> <option value="organoids" > Organoids </option> <option value="osteology" > Osteology </option> <option value="oxygen" > Oxygen </option> <option value="parasitologia" > Parasitologia </option> <option value="particles" > Particles </option> <option value="pathogens" > Pathogens </option> <option value="pathophysiology" > Pathophysiology </option> <option value="pediatrrep" > Pediatric Reports </option> <option value="pets" > Pets </option> <option value="pharmaceuticals" > Pharmaceuticals </option> <option value="pharmaceutics" > Pharmaceutics </option> <option value="pharmacoepidemiology" > Pharmacoepidemiology </option> <option value="pharmacy" > Pharmacy </option> <option value="philosophies" > Philosophies </option> <option value="photochem" > Photochem </option> <option value="photonics" > Photonics </option> <option value="phycology" > Phycology </option> <option value="physchem" > Physchem </option> <option value="psf" > Physical Sciences Forum </option> <option value="physics" > Physics </option> <option value="physiologia" > Physiologia </option> <option value="plants" > Plants </option> <option value="plasma" > Plasma </option> <option value="platforms" > Platforms </option> <option value="pollutants" > Pollutants </option> <option value="polymers" > Polymers </option> <option value="polysaccharides" > Polysaccharides </option> <option value="populations" > Populations </option> <option value="poultry" > Poultry </option> <option value="powders" > Powders </option> <option value="proceedings" > Proceedings </option> <option value="processes" > Processes </option> <option value="prosthesis" > Prosthesis </option> <option value="proteomes" > Proteomes </option> <option 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Med.) </option> <option value="resources" > Resources </option> <option value="rheumato" > Rheumato </option> <option value="risks" > Risks </option> <option value="robotics" > Robotics </option> <option value="ruminants" > Ruminants </option> <option value="safety" > Safety </option> <option value="sci" > Sci </option> <option value="scipharm" > Scientia Pharmaceutica (Sci. Pharm.) </option> <option value="sclerosis" > Sclerosis </option> <option value="seeds" > Seeds </option> <option value="sensors" > Sensors </option> <option value="separations" > Separations </option> <option value="sexes" > Sexes </option> <option value="signals" > Signals </option> <option value="sinusitis" > Sinusitis </option> <option value="smartcities" > Smart Cities </option> <option value="socsci" > Social Sciences </option> <option value="siuj" > Société Internationale d’Urologie Journal (SIUJ) </option> <option value="societies" > Societies </option> <option value="software" > Software </option> <option value="soilsystems" > Soil Systems </option> <option value="solar" > Solar </option> <option value="solids" > Solids </option> <option value="spectroscj" > Spectroscopy Journal </option> <option value="sports" > Sports </option> <option value="standards" > Standards </option> <option value="stats" > Stats </option> <option value="stresses" > Stresses </option> <option value="surfaces" > Surfaces </option> <option value="surgeries" > Surgeries </option> <option value="std" > Surgical Techniques Development </option> <option value="sustainability" > Sustainability </option> <option value="suschem" > Sustainable Chemistry </option> <option value="symmetry" > Symmetry </option> <option value="synbio" > SynBio </option> <option value="systems" > Systems </option> <option value="targets" > Targets </option> <option value="taxonomy" > Taxonomy </option> <option value="technologies" > Technologies </option> <option value="telecom" > Telecom </option> <option value="textiles" > Textiles </option> <option value="thalassrep" > Thalassemia Reports </option> <option value="therapeutics" > Therapeutics </option> <option value="thermo" > Thermo </option> <option value="timespace" > Time and Space </option> <option value="tomography" > Tomography </option> <option value="tourismhosp" > Tourism and Hospitality </option> <option value="toxics" > Toxics </option> <option value="toxins" > Toxins </option> <option value="transplantology" > Transplantology </option> <option value="traumacare" > Trauma Care </option> <option value="higheredu" > Trends in Higher Education </option> <option value="tropicalmed" > Tropical Medicine and Infectious Disease (TropicalMed) </option> <option value="universe" > Universe </option> <option value="urbansci" > Urban Science </option> <option value="uro" > Uro </option> <option value="vaccines" > Vaccines </option> <option value="vehicles" > Vehicles </option> <option value="venereology" > Venereology </option> <option value="vetsci" > Veterinary Sciences </option> <option value="vibration" > Vibration </option> <option value="virtualworlds" > Virtual Worlds </option> <option value="viruses" > Viruses </option> <option value="vision" > Vision </option> <option value="waste" > Waste </option> <option value="water" > Water </option> <option value="wild" > Wild </option> <option value="wind" > Wind </option> <option 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<a href="/2077-0383/13/17/5225"> <img src="https://pub.mdpi-res.com/title_story/title_story_17310472890295.jpg?1732286508" alt="Vitiligo: From Pathogenesis to Treatment" /> <div class="orbit-caption"> Vitiligo: From Pathogenesis to Treatment </div> </a> </li> <li class="hidden"> <a href="/2077-0383/13/19/6014"> <img src="https://pub.mdpi-res.com/title_story/title_story_17310472445542.jpg?1732286508" alt="Acute Ischemic Stroke during Extracorporeal Membrane Oxygenation (ECMO): A Narrative Review of the Literature" /> <div class="orbit-caption"> Acute Ischemic Stroke during Extracorporeal Membrane Oxygenation (ECMO): A Narrative Review of the Literature </div> </a> </li> <li class="hidden"> <a href="/2077-0383/13/19/6020"> <img src="https://pub.mdpi-res.com/title_story/title_story_17310471905918.jpg?1732286508" alt="Bronchoscopic Diagnosis of Severe Respiratory Infections" /> <div class="orbit-caption"> Bronchoscopic Diagnosis of Severe Respiratory Infections </div> </a> </li> <li class="hidden"> <a href="/2077-0383/13/16/4731"> <img src="https://pub.mdpi-res.com/title_story/title_story_17310468990434.jpg?1732286508" alt="The Importance of Mind&ndash;Body in Pilates Method in Patients with Chronic Non-Specific Low Back Pain&mdash;A Randomized Controlled Trial" /> <div class="orbit-caption"> The Importance of Mind–Body in Pilates Method in Patients with Chronic Non-Specific Low Back Pain—A Randomized Controlled Trial </div> </a> </li> <li class="hidden"> <a href="/2077-0383/13/17/5191"> <img src="https://pub.mdpi-res.com/title_story/title_story_17310468138282.jpg?1732286508" alt="Pulsed Field Ablation: A Comprehensive Update" /> <div class="orbit-caption"> Pulsed Field Ablation: A Comprehensive Update </div> </a> </li> </ul> </div> </div> <div class="content__container"> <div class="custom-accordion-for-small-screen-link show-for-small-only"> <h2 class="no-padding-left no-margin">Journal Description</h2> </div> <div class="custom-accordion-for-small-screen-content show-for-medium-up"> <div class="journal__description"> <h1> <em>Journal of Clinical Medicine</em> </h1> <div class="journal__description__content"> <em>Journal of Clinical Medicine</em> is an international, <a href="https://www.mdpi.com/editorial_process">peer-reviewed</a>, open access journal of clinical medicine, published semimonthly online by MDPI. The <a href="https://www.ibra.net/">International Bone Research Association (IBRA)</a>, <a href="https://www.ircouncil.it/">Italian Resuscitation Council (IRC)</a>, <a href="https://www.sehh.es/conocenos/la-sehh-fehh">Spanish Society of Hematology and Hemotherapy (SEHH)</a>, <a href="https://ja-ces.or.jp/english/">Japan Association for Clinical Engineers (JACE)</a>, <a href="https://www.vas-int.net/vas-for-angiology-vascular-medicine/">European Independent Foundation in Angiology/ Vascular Medicine (VAS)</a> and <a href="https://www.mdpi.com/journal/jcm/societies">others</a> are all affiliated with <em>JCM</em><em>,</em> and their members receive a discount on article processing charges.<br /> <ul> <li><span class="label openaccess"><a title="Open Access" href="https://www.mdpi.com/openaccess">Open Access</a></span>— free for readers, with <a href="https://www.mdpi.com/journal/jcm/apc">article processing charges (APC)</a> paid by authors or their institutions.</li> <li><strong>High Visibility:</strong> indexed within <a href="https://www.scopus.com/sourceid/21101054449">Scopus</a>, <a href="https://mjl.clarivate.com/search-results?issn=2077-0383&hide_exact_match_fl=true&utm_source=mjl&utm_medium=share-by-link&utm_campaign=search-results-share-this-journal">SCIE (Web of Science)</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22j+clin+med.%22%5Bjournal%5D&sort=pubdate">PubMed</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/journals/2745/">PMC</a>, <a href="https://www.embase.com/login">Embase</a>, <a href="https://sso.cas.org/as/authorization.oauth2?response_type=code&client_id=scifinder-n&redirect_uri=https%3A%2F%2Fscifinder-n.cas.org%2Fpa%2Foidc%2Fcb&state=eyJ6aXAiOiJERUYiLCJhbGciOiJkaXIiLCJlbmMiOiJBMTI4Q0JDLUhTMjU2Iiwia2lkIjoianMiLCJzdWZmaXgiOiJUYWozcGUu">CAPlus / SciFinder</a>, and <a href="https://www.mdpi.com/journal/jcm/indexing">other databases</a>.</li> <li><strong><strong>Journal Rank: </strong></strong>JCR - Q1 (</em>Medicine, General and Internal</em>) / CiteScore - Q1 (</em>General Medicine</em>)</li> <li><strong>Rapid Publication:</strong> manuscripts are peer-reviewed and a first decision is provided to authors approximately 17.3 days after submission; acceptance to publication is undertaken in 2.7 days (median values for papers published in this journal in the first half of 2024).</li> <li><strong>Recognition of Reviewers:</strong> reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.</li> <li><strong>Companion journals for <em>JCM</em> include:</strong> <em><a href="https://www.mdpi.com/journal/epidemiologia">Epidemiologia</a></em>, <em><a href="https://www.mdpi.com/journal/transplantology">Transplantology</a></em>, <em><a href="https://www.mdpi.com/journal/uro">Uro</a></em>, <em><a href="https://www.mdpi.com/journal/sinusitis">Sinusitis</a></em>, <em><a href="https://www.mdpi.com/journal/rheumato">Rheumato</a></em>, <em><a href="https://www.mdpi.com/journal/JCTO">Journal of Clinical & Translational Ophthalmology</a>,</em> <em><a href="https://www.mdpi.com/journal/jvd">Journal of Vascular Diseases</a>,</em> <em><a href="https://www.mdpi.com/journal/osteology">Osteology</a>,</em> <a href="https://www.mdpi.com/journal/complications"><em>Complications</em></a>, <a href="https://www.mdpi.com/journal/therapeutics"><em>Therapeutics</em></a>, and <a href="https://www.mdpi.com/journal/sclerosis"><em>Sclerosis</em></a>.</li> </ul> </div> <div style="margin-bottom: 15px;"> <strong>Impact Factor:</strong> 3.0 (2023); 5-Year Impact Factor: 3.4 (2023) </div> <div> <a href="/journal/jcm/imprint" class="UI_JournalImprintsInfoButton"> <i class="material-icons spaced-link">subject</i> Imprint Information </a>    <a href="/journal/jcm/jcm_flyer.pdf" class="UD_JournalFlyer"> <i class="material-icons spaced-link">get_app</i> Journal Flyer </a>     <a class="oa-link" href="https://www.mdpi.com/about/openaccess"> <i class="material icons spaced-link"></i> Open Access </a>     <strong> ISSN: 2077-0383 </strong> </div> <div style="clear: both;"></div> </div> </div> </div> <div class="content__container content__container--overflow-initial"> <div class="custom-accordion-for-small-screen-link active"> <h2 class="no-padding-left">Latest Articles</h2> </div> <div class="custom-accordion-for-small-screen-content"> <div class="expanding-div collapsed"> <div class="generic-item article-item no-border"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 16 pages, 419 KiB   </span> <a href="/2077-0383/13/23/7076/pdf?version=1732296377" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="The Predictive Power of the Transplant Evaluation Rating Scale (TERS) for Psychosocial Outcomes in Living-Donor Kidney Transplant Recipients: A Two-Year Prospective Study" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7076">The Predictive Power of the Transplant Evaluation Rating Scale (TERS) for Psychosocial Outcomes in Living-Donor Kidney Transplant Recipients: A Two-Year Prospective Study</a> <div class="authors"> by <span class="inlineblock "><strong>Ernst Peter Richter</strong>, </span><span class="inlineblock "><strong>Betty Schlegel</strong> and </span><span class="inlineblock "><strong>Hendrik Berth</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7076; https://doi.org/10.3390/jcm13237076 (registering DOI) - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> The Transplant Evaluation Rating Scale (TERS) assesses the psychosocial risk of transplant candidates; however, its predictive value for outcomes in living-donor kidney transplant (LDKT) recipients remains unclear. This study evaluated the predictive power of the TERS for psychosocial outcomes in LDKT recipients <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7076/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> The Transplant Evaluation Rating Scale (TERS) assesses the psychosocial risk of transplant candidates; however, its predictive value for outcomes in living-donor kidney transplant (LDKT) recipients remains unclear. This study evaluated the predictive power of the TERS for psychosocial outcomes in LDKT recipients over two years post-transplant. <b>Methods:</b> In this prospective single-center cohort study, 107 LDKT recipients completed assessments pre-transplant (T0), 6 months post-transplant (T1), and 24 months post-transplant (T2). The outcomes measured were mental distress, physical complaints, and perceived social support. Linear mixed-effects models were used to examine the relationship between the pre-transplant TERS scores and outcomes over time. <b>Results:</b> Higher TERS scores predicted increased physical complaints (<i>p</i> < 0.001) and lower perceived social support (<i>p</i> = 0.035) at all time points. Additionally, higher TERS scores were associated with greater mental distress between T0 and T2 (<i>p</i> < 0.001). A hierarchical partitioning revealed that the TERS accounted for 11.9% of the variance in mental distress, 14.6% of that in physical complaints, and 6.0% of that in perceived social support. <b>Conclusions:</b> The pre-transplant psychosocial risk, as measured by the TERS, significantly predicted the psychosocial outcomes in the LDKT recipients over two years, with small-to-medium effect sizes. The TERS may serve as a valuable tool for identifying patients who could benefit from targeted psychosocial interventions to improve their long-term outcomes. <a href="/2077-0383/13/23/7076">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Mental_Health">Mental Health</a>)<br/> </div> </div> </div> </div> <div class="extending-content content-ready"> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 16 pages, 1032 KiB   </span> <a href="/2077-0383/13/23/7075/pdf?version=1732294252" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Hybrid Aortic Arch Replacement with Frozen Elephant Trunk (FET) Technique: Surgical Considerations, Pearls, and Pitfalls" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2077-0383/13/23/7075">Hybrid Aortic Arch Replacement with Frozen Elephant Trunk (FET) Technique: Surgical Considerations, Pearls, and Pitfalls</a> <div class="authors"> by <span class="inlineblock "><strong>Dimos Karangelis</strong>, </span><span class="inlineblock "><strong>Theodora M. Stougiannou</strong>, </span><span class="inlineblock "><strong>Konstantinos C. Christodoulou</strong>, </span><span class="inlineblock "><strong>Henri Bartolozzi</strong>, </span><span class="inlineblock "><strong>Maria Eleni Malafi</strong>, </span><span class="inlineblock "><strong>Fotios Mitropoulos</strong>, </span><span class="inlineblock "><strong>Dimitrios Mikroulis</strong> and </span><span class="inlineblock "><strong>Martin Bena</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7075; <a href="https://doi.org/10.3390/jcm13237075">https://doi.org/10.3390/jcm13237075</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> The involvement of the aortic arch in thoracic aortic aneurysms (TAA), or acute aortic dissections (AAD), represents a challenging clinical entity, mandating a meticulous surgical plan, tailored to each individual case. The advent of endovascular techniques and the introduction of modern arch protheses <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7075/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> The involvement of the aortic arch in thoracic aortic aneurysms (TAA), or acute aortic dissections (AAD), represents a challenging clinical entity, mandating a meticulous surgical plan, tailored to each individual case. The advent of endovascular techniques and the introduction of modern arch protheses have led to the implementation of the frozen elephant trunk (FET) technique. This one-step hybrid operation consists of a total aortic arch replacement combined with an antegrade delivery of a stent–graft for the descending aorta, which acts as a proximal landing zone facilitating a potential distal endovascular reintervention. In this manner, this technique addresses acute and chronic arch disease with an acceptable morbidity and mortality. Several FET prosthetic devices are available on the global market and have exhibited favourable outcomes, although with some disadvantages in complex cases; similarly, the hybrid procedure described in this review has also been associated with complications, such as coagulopathy and neurological and graft-related events. The purpose of this review is to thus provide key insights into successful hybrid aortic arch replacements and to discuss useful tips and relevant considerations regarding its use. <a href="/2077-0383/13/23/7075">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/297A72TN5S ">Current Practice and Future Perspectives in Aortic Surgery</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 444 KiB   </span> <a href="/2077-0383/13/23/7074/pdf?version=1732294816" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Real-World Clinical Effectiveness and Safety of Antifibrotics in Progressive Pulmonary Fibrosis Associated with Rheumatoid Arthritis" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7074">Real-World Clinical Effectiveness and Safety of Antifibrotics in Progressive Pulmonary Fibrosis Associated with Rheumatoid Arthritis</a> <div class="authors"> by <span class="inlineblock "><strong>Javier Narváez</strong>, </span><span class="inlineblock "><strong>Martí Aguilar-Coll</strong>, </span><span class="inlineblock "><strong>Vanesa Vicens-Zygmunt</strong>, </span><span class="inlineblock "><strong>Juan José Alegre</strong>, </span><span class="inlineblock "><strong>Guadalupe Bermudo</strong> and </span><span class="inlineblock "><strong>María Molina-Molina</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7074; <a href="https://doi.org/10.3390/jcm13237074">https://doi.org/10.3390/jcm13237074</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Interstitial lung disease (ILD) is one of the most severe complications of rheumatoid arthritis (RA). Real-world data on antifibrotic treatment are needed. Our objective was to evaluate the real-world effectiveness and tolerability of antifibrotic agents in patients with progressive fibrosing RA-ILD. <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7074/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Interstitial lung disease (ILD) is one of the most severe complications of rheumatoid arthritis (RA). Real-world data on antifibrotic treatment are needed. Our objective was to evaluate the real-world effectiveness and tolerability of antifibrotic agents in patients with progressive fibrosing RA-ILD. <b>Methods:</b> A longitudinal, retrospective, observational study was conducted on a cohort of RA-ILD patients treated with either nintedanib or pirfenidone. The data collected included pulmonary function test (PFT) results, adverse events (AEs), tolerability, and drug retention. <b>Results:</b> Twenty-seven patients were included; 25 (92.5%) initiated nintedanib, while two initiated pirfenidone. The median follow-up duration was 25 months (IQR 7–27). The mean decline in %pFVC and %pDLCO from ILD diagnosis to the initiation of antifibrotic therapy were −8.9% and −14.8%, respectively. After 6 months of treatment, most patients achieved stabilization in PFT: a ∆%pFVC of +1.2% (<i>p </i>= 0.611 compared with baseline) and a ∆%pDLCO of +3.9% (<i>p </i>= 0.400). Eighteen patients completed one year of therapy, with a modest improvement in %pFVC (+4.7%; <i>p </i>= 0.023) and stabilization in %pDLCO (−3.8%; <i>p </i>= 0.175). This trend persisted among the nine patients who completed 2 years of treatment (%pFVC +7.7%; <i>p </i>= 0.037 and %pDLCO −2.2%; <i>p </i>= 0.621). During the follow-up period, 15% of patients died, and 4% underwent lung transplantation. Adverse events occurred in 81% of patients, leading to discontinuation in 18.5% of cases. The most frequent adverse events were gastrointestinal events and hepatitis, leading to a permanent dose reduction of 40% for nintedanib and 14% for pirfenidone. A second antifibrotic agent was prescribed for 18.5% of the patients. At the end of the follow-up period, 63% of the total cohort remained on antifibrotic therapy. <b>Conclusions:</b> According to our results, antifibrotic initiation was associated with a modest improvement in the trajectory of %pFVC and stabilization in %pDLCO. The discontinuation rate in our cohort (37%) was higher than that reported in clinical trials but similar to that reported in previously published real-world studies. <a href="/2077-0383/13/23/7074">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/1D32Y0W831 ">Rheumatoid Arthritis: Clinical Updates on Diagnosis and Treatment</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 11 pages, 867 KiB   </span> <a href="/2077-0383/13/23/7073/pdf?version=1732291051" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Incidence and Treatment of Arginine Vasopressin Deficiency (Central Diabetes Insipidus) in the Setting of Brain Death and Associations with Renal Function and Hemodynamics in Organ Donors" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7073">Incidence and Treatment of Arginine Vasopressin Deficiency (Central Diabetes Insipidus) in the Setting of Brain Death and Associations with Renal Function and Hemodynamics in Organ Donors</a> <div class="authors"> by <span class="inlineblock "><strong>Marleen Weiß</strong>, </span><span class="inlineblock "><strong>Fabian Rücker</strong>, </span><span class="inlineblock "><strong>Volker Thieme</strong>, </span><span class="inlineblock "><strong>Karsten Hochmuth</strong>, </span><span class="inlineblock "><strong>Dominik Michalski</strong>, </span><span class="inlineblock "><strong>Björn Nashan</strong>, </span><span class="inlineblock "><strong>Hans-Michael Tautenhahn</strong>, </span><span class="inlineblock "><strong>Robert Werdehausen</strong> and </span><span class="inlineblock "><strong>Svitlana Ziganshyna</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7073; <a href="https://doi.org/10.3390/jcm13237073">https://doi.org/10.3390/jcm13237073</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Arginine vasopressin deficiency (AVP-D) is a common condition in the setting of brain death. The aim of this study was to analyze the frequency of AVP-D in organ donors, its treatment, as well as the impact of AVP-D on hemodynamics and <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7073/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Arginine vasopressin deficiency (AVP-D) is a common condition in the setting of brain death. The aim of this study was to analyze the frequency of AVP-D in organ donors, its treatment, as well as the impact of AVP-D on hemodynamics and renal function. <b>Methods</b>: This single-center, retrospective study included 63 organ donors treated between 2017 and 2022. We used standard criteria to examine the incidence of AVP-D and the KDIGO criteria to determine the rate of acute kidney injury (AKI). <b>Results</b>: AVP-D occurred in 79% of the examined organ donors, of which 94% received desmopressin. Overall, 30% of organ donors developed AKI. AKI was present in 77% of donors who did not meet AVP-D criteria and in only 18% of donors with AVP-D <i>(p </i>< 0.001<i>)</i>. Mean arterial blood pressure did not differ between organ donors with and without AVP-D or with and without desmopressin therapy. In organ donors with AVP-D, norepinephrine requirement in the period 24 h prior to AVP-D diagnosis was lower than 24 h afterwards <i>(p </i>= 0.03<i>)</i>. AVP-D diagnosis was associated with a higher rate of kidney transplantation compared to cases without AVP-D diagnosis (88% vs. 54%, <i>p </i>= 0.01). <b>Conclusion</b><b>s</b>: AVP-D is common among brain death organ donors and may remain undiagnosed in cases with previous kidney injury. These observations highlight the importance of recognizing AVP-D and administering appropriate therapy in potential organ donors to prevent AKI. <a href="/2077-0383/13/23/7073">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Nephrology_Urology">Nephrology & Urology</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 17 pages, 465 KiB   </span> <a href="/2077-0383/13/23/7072/pdf?version=1732289154" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Do Acute Illness Perceptions Moderate the Association of Pre-Collision Welfare Benefits and Later Neck Pain or Disability Following Whiplash Trauma? A Prospective Multicentre Cohort Study" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7072">Do Acute Illness Perceptions Moderate the Association of Pre-Collision Welfare Benefits and Later Neck Pain or Disability Following Whiplash Trauma? A Prospective Multicentre Cohort Study</a> <div class="authors"> by <span class="inlineblock "><strong>Tina B. W. Carstensen</strong>, </span><span class="inlineblock "><strong>Sophie L. Ravn</strong>, </span><span class="inlineblock "><strong>Tonny E. Andersen</strong>, </span><span class="inlineblock "><strong>Solbjørg M. M. Sæther</strong>, </span><span class="inlineblock "><strong>Eva Ørnbøl</strong>, </span><span class="inlineblock "><strong>Kaare B. Wellnitz</strong>, </span><span class="inlineblock "><strong>Helge Kasch</strong> and </span><span class="inlineblock "><strong>Lisbeth Frostholm</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7072; <a href="https://doi.org/10.3390/jcm13237072">https://doi.org/10.3390/jcm13237072</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Objectives</b>: Whiplash trauma is a worldwide significant public health issue, with post-collision chronic pain and physical and mental disability; the prevalence of whiplash trauma in the Japanese general population is estimated at 1.2% and in the Danish general population the whiplash condition <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7072/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Objectives</b>: Whiplash trauma is a worldwide significant public health issue, with post-collision chronic pain and physical and mental disability; the prevalence of whiplash trauma in the Japanese general population is estimated at 1.2% and in the Danish general population the whiplash condition has been reported to be 2.9%. Pre-collision welfare benefits and illness perceptions have been found to predict poor recovery after whiplash trauma. In this study, we examined whether illness perceptions measured shortly post-collision moderated the effect of welfare benefits five years before the collision on neck pain and neck-related disability one-year post-collision. <b>Methods</b>: Patients consulting emergency rooms or general practices with neck pain after acute whiplash trauma were invited to complete questionnaires during the week after the collision and at three and 12-months post-collision. Further, we obtained register data on the number of weeks on three types of welfare benefits (sick leave benefits, unemployment benefits, and social assistance benefits) for a five-year period before the collision. Multiple logistic regression was applied. <b>Results</b>: 740 patients were included. We did not find a significant moderating effect of illness perceptions on the association between pre-collision welfare benefits and chronic neck pain and related disability. However, there was a trend towards illness perceptions at baseline and at the three-month follow-up having a moderating effect on the relationship between long-term sick leave and neck pain one year after the whiplash collision. <b>Conclusions:</b> Regarding long-term sick leave, we might have overlooked a substantial moderating effect due to methodological matters and recommend a replication of this study on a larger sample, also focusing on other recovery outcomes. <a href="/2077-0383/13/23/7072">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Mental_Health">Mental Health</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 13 pages, 521 KiB   </span> <a href="/2077-0383/13/23/7071/pdf?version=1732288689" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Association Between Sarcopenic Obesity and Activities of Daily Living in Individuals with Spinal Cord Injury" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7071">Association Between Sarcopenic Obesity and Activities of Daily Living in Individuals with Spinal Cord Injury</a> <div class="authors"> by <span class="inlineblock "><strong>Ryu Ishimoto</strong>, </span><span class="inlineblock "><strong>Hirotaka Mutsuzaki</strong>, </span><span class="inlineblock "><strong>Yukiyo Shimizu</strong>, </span><span class="inlineblock "><strong>Ryoko Takeuchi</strong>, </span><span class="inlineblock "><strong>Shuji Matsumoto</strong> and </span><span class="inlineblock "><strong>Yasushi Hada</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7071; <a href="https://doi.org/10.3390/jcm13237071">https://doi.org/10.3390/jcm13237071</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Sarcopenic obesity adversely affects physical function and activities of daily living (ADL) in older individuals and patients undergoing rehabilitation. This condition is also common in individuals with spinal cord injury (SCI); however, its relationship with ADL in this group remains unclear. <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7071/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Sarcopenic obesity adversely affects physical function and activities of daily living (ADL) in older individuals and patients undergoing rehabilitation. This condition is also common in individuals with spinal cord injury (SCI); however, its relationship with ADL in this group remains unclear. Hence, this study examined the association between sarcopenic obesity and ADL in individuals with SCI. <b>Methods</b>: This retrospective cross-sectional study identified sarcopenia using the low skeletal muscle mass index (SMI) and Asian Working Group for Sarcopenia reference values. Obesity was defined as a body fat percentage (%BF) exceeding 25% in men and 35% in women. Sarcopenic obesity was identified when both the sarcopenia and obesity criteria were met. The primary outcome, ADL, was measured using the Functional Independence Measure (FIM). Multiple linear regression models were used to analyze the associations among the SMI, %BF, and FIM scores, after adjusting for age, sex, lesion level, injury severity, comorbidities, and injury duration. <b>Results</b>: Of 82 participants (median age: 63.5 years; 18.3% women), 62.2% had sarcopenic obesity. Participants with sarcopenic obesity (54 vs. 69 points, <i>p</i> = 0.006) had significantly lower FIM motor scores than those without this condition. Multiple linear regression analysis revealed that SMI (β = 0.416, <i>p</i> < 0.001) and %BF (β = −0.325, <i>p</i> = 0.009) were independently associated with the FIM motor scores. <b>Conclusion</b><b>s</b>: Decreased SMI and increased %BF in patients with SCI were independently associated with decreased ADL independence. Routine body composition assessments are necessary for early detection and intervention in this population. <a href="/2077-0383/13/23/7071">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/AGUAO1PLH0 ">Clinical Management and Rehabilitation of Spinal Cord Injury</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 21 pages, 2338 KiB   </span> <a href="/2077-0383/13/23/7070/pdf?version=1732287265" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="The Clinical Usefulness of Evaluating the Lens and Intraocular Lenses Using Optical Coherence Tomography: An Updated Literature Review" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2077-0383/13/23/7070">The Clinical Usefulness of Evaluating the Lens and Intraocular Lenses Using Optical Coherence Tomography: An Updated Literature Review</a> <div class="authors"> by <span class="inlineblock "><strong>José Ignacio Fernández-Vigo</strong>, </span><span class="inlineblock "><strong>Lucía De-Pablo-Gómez-de-Liaño</strong>, </span><span class="inlineblock "><strong>Ignacio Almorín-Fernández-Vigo</strong>, </span><span class="inlineblock "><strong>Beatriz De-Pablo-Gómez-de-Liaño</strong>, </span><span class="inlineblock "><strong>Ana Macarro-Merino</strong>, </span><span class="inlineblock "><strong>Julián García-Feijóo</strong> and </span><span class="inlineblock "><strong>José Ángel Fernández-Vigo</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7070; <a href="https://doi.org/10.3390/jcm13237070">https://doi.org/10.3390/jcm13237070</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> The Lens Dysfunction Syndrome includes two widespread ocular disorders: presbyopia and cataract. Understanding its etiology, onset, progression, impact, prevention, and treatment remains a significant scientific challenge. The lens is a fundamental structure of the ocular dioptric system that allows for focus adjustment or <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7070/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> The Lens Dysfunction Syndrome includes two widespread ocular disorders: presbyopia and cataract. Understanding its etiology, onset, progression, impact, prevention, and treatment remains a significant scientific challenge. The lens is a fundamental structure of the ocular dioptric system that allows for focus adjustment or accommodation to view objects at different distances. Its opacification, primarily related to aging, leads to the development of cataracts. Traditionally, lens alterations have been diagnosed using a slit lamp and later with devices based on the Scheimpflug camera. However, both methods have significant limitations. In recent years, optical coherence tomography (OCT) has become a valuable tool for assessing the lens and pseudophakic intraocular lenses (IOLs) in clinical practice, providing a highly detailed non-invasive evaluation of these structures. Its clinical utility has been described in assessing the shape, location or position, and size of the lens, as well as in determining the degree and type of cataract and its various components. Regarding pseudophakic IOLs, OCT allows for the accurate assessment of their position and centering, as well as for detecting possible complications, including the presence of glistening or IOL opacification. Furthermore, OCT enables the evaluation of the posterior capsule and its associated pathologies, including late capsular distension syndrome. This review highlights the key applications of OCT in the assessment of the lens and pseudophakic IOLs. <a href="/2077-0383/13/23/7070">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/65M6XBM9O0 ">Clinical Utility of Optical Coherence Tomography in Ophthalmology: 2nd Edition</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 11 pages, 479 KiB   </span> <a href="/2077-0383/13/23/7069/pdf?version=1732286484" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Screening for Fabry Disease-Related Mutations Among 829 Kidney Transplant Recipients" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7069">Screening for Fabry Disease-Related Mutations Among 829 Kidney Transplant Recipients</a> <div class="authors"> by <span class="inlineblock "><strong>Marina Kljajic</strong>, </span><span class="inlineblock "><strong>Armin Atic</strong>, </span><span class="inlineblock "><strong>Ivan Pecin</strong>, </span><span class="inlineblock "><strong>Bojan Jelakovic</strong> and </span><span class="inlineblock "><strong>Nikolina Basic-Jukic</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7069; <a href="https://doi.org/10.3390/jcm13237069">https://doi.org/10.3390/jcm13237069</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <strong>Background/Objectives</strong>: Fabry disease (FD) is a genetic lysosomal storage disease caused by a pathogenic variant in GLA gene coding for a functional alpha-galactosidase A enzyme whose disfunction leads to globotriaosylceramide (Gb3) accumulation in cells, which results in multiple organ disorders. The aim <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7069/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <strong>Background/Objectives</strong>: Fabry disease (FD) is a genetic lysosomal storage disease caused by a pathogenic variant in GLA gene coding for a functional alpha-galactosidase A enzyme whose disfunction leads to globotriaosylceramide (Gb3) accumulation in cells, which results in multiple organ disorders. The aim of this study was to identify mutations associated with Fabry disease among 829 kidney transplant recipients and to investigate the correlation between the factors such as age, dialysis vintage, eGFR, proteinuria and corticosteroid dose and the deviations in alpha-galactosidase A and lyso-Gb3 levels. <b>Methods:</b> Dry blood spot samples were collected for genetic analysis. The GLA genetic variants were analysed by an amplicon-based next-generation sequencing approach in all female patients and in male patients with reduced alpha-galactosidase A levels. Alpha-galactosidase A and Lyso-Gb3 were not determined in female patients. Pearson’s correlation coefficient was used to assess the relationship between the above-mentioned factors with the activity of alpha-galactosidase A and Lyso-Gb3. <b>Results:</b> Genetic testing was performed in 476 patients, all female patients (333), 69 male patients with decreased level of alpha-galactosidase A activity and 61 male patients with no interpretable results of alpha-galactosidase A activity due to preanalytical error. In 3 (0.4%) male patients, hemizygous mutations associated with Fabry disease were found, and those were c.427G&gt;A p.(Ala143Thr), c.1181T&gt;C p.(Leu394Pro), and c.352C&gt;T p.(Arg118Cys). The dose of corticosteroid therapy seemed to be positively correlated to alpha-galactosidase A activity and negatively to Lyso-Gb3 levels in blood. <b>Conclusions</b>: Genetic testing of individuals with chronic kidney disease and reporting of genetic variants associated with the Fabry phenotype are important to improve the overall knowledge of the disease. Further research is needed to define factors influencing levels of alpha-galactosidase A and Lyso-Gb3. <a href="/2077-0383/13/23/7069">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Nephrology_Urology">Nephrology & Urology</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1527361" aria-controls="drop-supplementary-1527361" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1527361" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7068/s1?version=1732286738"> Supplementary File 1 (ZIP, 257 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 23 pages, 541 KiB   </span> <a href="/2077-0383/13/23/7068/pdf?version=1732291648" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="The Potential of Automated Assessment of Cognitive Function Using Non-Neuroimaging Data: A Systematic Review" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Systematic Review</span></div> <a class="title-link" href="/2077-0383/13/23/7068">The Potential of Automated Assessment of Cognitive Function Using Non-Neuroimaging Data: A Systematic Review</a> <div class="authors"> by <span class="inlineblock "><strong>Eyitomilayo Yemisi Babatope</strong>, </span><span class="inlineblock "><strong>Alejandro Álvaro Ramírez-Acosta</strong>, </span><span class="inlineblock "><strong>José Alberto Avila-Funes</strong> and </span><span class="inlineblock "><strong>Mireya García-Vázquez</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7068; <a href="https://doi.org/10.3390/jcm13237068">https://doi.org/10.3390/jcm13237068</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> The growing incidence of cognitive impairment among older adults has a significant impact on individuals, family members, caregivers, and society. Current conventional cognitive assessment tools are faced with some limitations. Recent evidence suggests that automating cognitive assessment holds promise, potentially resulting in <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7068/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> The growing incidence of cognitive impairment among older adults has a significant impact on individuals, family members, caregivers, and society. Current conventional cognitive assessment tools are faced with some limitations. Recent evidence suggests that automating cognitive assessment holds promise, potentially resulting in earlier diagnosis, timely intervention, improved patient outcomes, and higher chances of response to treatment. Despite the advantages of automated assessment and technological advancements, automated cognitive assessment has yet to gain widespread use, especially in low and lower middle-income countries. This review highlights the potential of automated cognitive assessment tools and presents an overview of existing tools. <b>Methods:</b> This review includes 87 studies carried out with non-neuroimaging data alongside their performance metrics. <b>Results:</b> The identified articles automated the cognitive assessment process and were grouped into five categories either based on the tools’ design or the data analysis approach. These categories include game-based, digital versions of conventional tools, original computerized tests and batteries, virtual reality/wearable sensors/smart home technologies, and artificial intelligence-based (AI-based) tools. These categories are further explained, and evaluation of their strengths and limitations is discussed to strengthen their adoption in clinical practice. <b>Conclusions:</b> The comparative metrics of both conventional and automated approaches of assessment suggest that the automated approach is a strong alternative to the conventional approach. Additionally, the results of the review show that the use of automated assessment tools is more prominent in countries ranked as high-income and upper middle-income countries. This trend merits further social and economic studies to understand the impact of this global reality. <a href="/2077-0383/13/23/7068">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Clinical_Neurology">Clinical Neurology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7068/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1527361-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07068/article_deploy/html/images/jcm-13-07068-g001-550.jpg?1732291745" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1527361-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07068/article_deploy/html/images/jcm-13-07068-g001-550.jpg?1732291745" title=" <strong>Figure 1</strong><br/> <p>PRISMA flow chart adapted for this study.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7068'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 11 pages, 366 KiB   </span> <a href="/2077-0383/13/23/7067/pdf?version=1732285724" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Management of Clinically Negative Neck in Early-Stage (T1-2N0) Oral Squamous-Cell Carcinoma (OSCC): Ten Years of a Single Institution’s Experience" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7067">Management of Clinically Negative Neck in Early-Stage (T1-2N0) Oral Squamous-Cell Carcinoma (OSCC): Ten Years of a Single Institution’s Experience</a> <div class="authors"> by <span class="inlineblock "><strong>Danilo Di Giorgio</strong>, </span><span class="inlineblock "><strong>Marco Della Monaca</strong>, </span><span class="inlineblock "><strong>Riccardo Nocini</strong>, </span><span class="inlineblock "><strong>Andrea Battisti</strong>, </span><span class="inlineblock "><strong>Federica Orsina Ferri</strong>, </span><span class="inlineblock "><strong>Paolo Priore</strong>, </span><span class="inlineblock "><strong>Valentina Terenzi</strong> and </span><span class="inlineblock "><strong>Valentino Valentini</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7067; <a href="https://doi.org/10.3390/jcm13237067">https://doi.org/10.3390/jcm13237067</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Oral cavity squamous-cell carcinoma is among the most frequent head and neck neoplasms. Early-stage T1/T2N0 accounts for 40/45% of new diagnoses. Of these, about 30% of cases hide occult metastases in the neck. The management of clinically N0 neck is of <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7067/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Oral cavity squamous-cell carcinoma is among the most frequent head and neck neoplasms. Early-stage T1/T2N0 accounts for 40/45% of new diagnoses. Of these, about 30% of cases hide occult metastases in the neck. The management of clinically N0 neck is of paramount importance and is still being debated. <b>Methods</b>: The medical records of patients with a clinical diagnosis of early-stage T1-T2N0 carcinoma of the oral cavity between 2011 and 2021 were retrospectively analysed. The inclusion criteria were complete medical and radiological records, pT1-2 pathology staging, and a minimum follow-up of 24 months. Biographical, management, and survival data were analysed using IBM SPSS Statistics [28.0.1.1]; IBM Corp., Armonk, NY, USA). <b>Results</b>: A total of 121 patients met the inclusion criteria. The tongue was the most affected site, with 52 cases. All patients underwent resection of the primary tumour; for neck management, 47 (38.8%) underwent elective neck dissection, 36 underwent follow-up, and 11 underwent sentinel lymph node biopsy. A total of 59 cases were staged as T1 and 62 as T2; in 97 (80.2%) cases, the neck was confirmed as N0; in 10 (8.3%), N1; in 1 case, N2a; in 8, N2b; in 2, N2c; and in 3, N3b. The mean DOI was 4.8 mm. In a Cox regression, a statistically significant association was shown between overall survival and pN staging (<i>p </i>< 0.05). Kaplan–Meier analysis showed a statistically significant difference between different regimens of management of the neck in terms of overall survival, disease-free survival, and disease-specific survival in favour of elective neck dissection and sentinel lymph node biopsy compared to watchful policy (<i>p </i>< 0.05). <b>Conclusion</b><b>s</b>: Elective neck dissection and sentinel lymph node biopsy proved to be safe and oncologically effective in the treatment of clinically N0 early-stage oral carcinoma. <a href="/2077-0383/13/23/7067">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Otolaryngology">Otolaryngology</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 11 pages, 449 KiB   </span> <a href="/2077-0383/13/23/7066/pdf?version=1732284848" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="How Did the COVID-19 Pandemic Affect Emergency Dental Trauma Settings in Permanent Dentition? A Retrospective Study" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7066">How Did the COVID-19 Pandemic Affect Emergency Dental Trauma Settings in Permanent Dentition? A Retrospective Study</a> <div class="authors"> by <span class="inlineblock "><strong>Florian Dudde</strong>, </span><span class="inlineblock "><strong>Manfred Giese</strong>, </span><span class="inlineblock "><strong>Oliver Schuck</strong> and </span><span class="inlineblock "><strong>Christina Krüger</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7066; <a href="https://doi.org/10.3390/jcm13237066">https://doi.org/10.3390/jcm13237066</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background</b>: The purpose of this study was to examine how the COVID-19 pandemic influenced the patterns, distribution, and circumstances of dental trauma (DT) cases at a German cranio-maxillofacial trauma center.<b> Materials</b> <b>and</b> <b>Methods</b><i>:</i> This retrospective analysis compared DT cases <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7066/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background</b>: The purpose of this study was to examine how the COVID-19 pandemic influenced the patterns, distribution, and circumstances of dental trauma (DT) cases at a German cranio-maxillofacial trauma center.<b> Materials</b> <b>and</b> <b>Methods</b><i>:</i> This retrospective analysis compared DT cases from the PreCovid (PC) period (February 2019–January 2020) with those from the IntraCovid (IC) period (February 2020–January 2021). It included an examination of baseline characteristics, types of DT, circumstances leading to DT, and the treatment approaches applied. <b>Results</b>: In the IC period, there was an increase in the number of DT, a significant increase in uncomplicated crown fractures, crown–root fractures, subluxations, avulsions, alveolar fractures, combined tooth fractures and dislocations, and concomitant soft tissue injuries. There were no differences regarding the location of DT. During the IC period there was a significant reduction in sports accidents, road traffic accidents, interpersonal violence, and alcohol-related DT. Simultaneously, there was a marked increase in falls, syncopal episodes, home accidents, and DT incidents occurring on weekdays. Furthermore, during the IC period, the number of cases of DT increased in the morning and decreased at nighttime. <b>Conclusion</b>: The COVID-19 pandemic significantly affected the types of DT, the treatment approaches, and the circumstances under which DT occurred. Investigating these impacts can help to predict the effects of a future pandemic on DT and/or maxillofacial trauma and possibly reduce these effects through establishing appropriate preventive measures. <a href="/2077-0383/13/23/7066">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Dentistry_Oral_Surgery_Oral_Medicine">Dentistry, Oral Surgery and Oral Medicine</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1527257" aria-controls="drop-supplementary-1527257" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1527257" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7065/s1?version=1732283137"> Supplementary File 1 (ZIP, 201 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 21 pages, 3538 KiB   </span> <a href="/2077-0383/13/23/7065/pdf?version=1732283136" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Global and Regional Sex-Related Differences, Asymmetry, and Peak Age of Brain Myelination in Healthy Adults" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7065">Global and Regional Sex-Related Differences, Asymmetry, and Peak Age of Brain Myelination in Healthy Adults</a> <div class="authors"> by <span class="inlineblock "><strong>Marina Y. Khodanovich</strong>, </span><span class="inlineblock "><strong>Mikhail V. Svetlik</strong>, </span><span class="inlineblock "><strong>Anna V. Naumova</strong>, </span><span class="inlineblock "><strong>Anna V. Usova</strong>, </span><span class="inlineblock "><strong>Valentina Y. Pashkevich</strong>, </span><span class="inlineblock "><strong>Marina V. Moshkina</strong>, </span><span class="inlineblock "><strong>Maria M. Shadrina</strong>, </span><span class="inlineblock "><strong>Daria A. Kamaeva</strong>, </span><span class="inlineblock "><strong>Victoria B. Obukhovskaya</strong>, </span><span class="inlineblock "><strong>Nadezhda G. Kataeva</strong>, </span><span class="inlineblock "><strong>Anastasia Y. Levina</strong>, </span><span class="inlineblock "><strong>Yana A. Tumentceva</strong> and </span><span class="inlineblock "><strong>Vasily L. Yarnykh</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7065; <a href="https://doi.org/10.3390/jcm13237065">https://doi.org/10.3390/jcm13237065</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background: </b>The fundamental question of normal brain myelination in human is still poorly understood.<b> Methods</b>: Age-dependent global, regional, and interhemispheric sex-related differences in brain myelination of 42 (19 men, 23 women) healthy adults (19–67 years) were explored using the MRI method of <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7065/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background: </b>The fundamental question of normal brain myelination in human is still poorly understood.<b> Methods</b>: Age-dependent global, regional, and interhemispheric sex-related differences in brain myelination of 42 (19 men, 23 women) healthy adults (19–67 years) were explored using the MRI method of fast macromolecular fraction (MPF) mapping. <b>Results</b>: Higher brain myelination in males compared to females was found in global white matter (WM), most WM tracts, juxtacortical WM regions, and putamen. The largest differences between men and women, exceeding 4%, were observed bilaterally in the frontal juxtacortical WM; angular, inferior occipital, and cuneus WM; external capsule; and inferior and superior fronto-orbital fasciculi. The majority of hemispheric differences in MPF were common to men and women. Sex-specific interhemispheric differences were found in juxtacortical WM; men more often had left-sided asymmetry, while women had right-sided asymmetry. Most regions of deep gray matter (GM), juxtacortical WM, and WM tracts (except for projection pathways) showed a later peak age of myelination in women compared to men, with a difference of 3.5 years on average. Body mass index (BMI) was associated with higher MPF and later peak age of myelination independent of age and sex. <b>Conclusions</b>: MPF mapping showed high sensitivity to assess sex-related differences in normal brain myelination, providing the basis for using this method in clinics. <a href="/2077-0383/13/23/7065">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/SKN00QLW5E ">Neuroimaging in 2024 and Beyond</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 22 pages, 5073 KiB   </span> <a href="/2077-0383/13/23/7064/pdf?version=1732283429" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="The Pattern of Cytokines, Chemokines, and Growth Factors of the Maxillary and Mandibular Periosteum After Exposure to Titanium Fixations—Ti6Al4V" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7064">The Pattern of Cytokines, Chemokines, and Growth Factors of the Maxillary and Mandibular Periosteum After Exposure to Titanium Fixations—Ti6Al4V</a> <div class="authors"> by <span class="inlineblock "><strong>Bożena Antonowicz</strong>, </span><span class="inlineblock "><strong>Mateusz Maciejczyk</strong>, </span><span class="inlineblock "><strong>Jan Borys</strong>, </span><span class="inlineblock "><strong>Kamila Łukaszuk</strong>, </span><span class="inlineblock "><strong>Sara Zięba</strong>, </span><span class="inlineblock "><strong>Edyta Gołaś</strong>, </span><span class="inlineblock "><strong>Małgorzata Żendzian-Piotrowska</strong> and </span><span class="inlineblock "><strong>Anna Zalewska</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7064; <a href="https://doi.org/10.3390/jcm13237064">https://doi.org/10.3390/jcm13237064</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Objectives:</b> Titanium miniplates and screws are commonly used in the surgical management of dentofacial deformities. Despite the opinion of the biocompatibility of these bone fixations, some patients experience symptoms of chronic inflammation around titanium implants even many years after their application. The aim <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7064/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Objectives:</b> Titanium miniplates and screws are commonly used in the surgical management of dentofacial deformities. Despite the opinion of the biocompatibility of these bone fixations, some patients experience symptoms of chronic inflammation around titanium implants even many years after their application. The aim of this study was to examine the levels of cytokines, chemokines, and growth factors released from the maxilla and mandible periosteum surrounding titanium fixations 11 months after the implantation procedure. <b>Methods:</b> From the study group (n = 20) consisting of patients with maxillofacial defects who underwent bimaxillary osteotomy, fragments of the periosteum of the maxilla and mandible adjacent to the titanium miniplates and screws were taken during routine bone fixation removal procedures. From the control group subjects (n = 20), fragments of healthy maxillary and mandibular periosteum were taken prior to surgical treatment of dentofacial deformities. The examination of cytokines, chemokines, and growth factors levels released from the periosteum of jaws was performed using the Bio-Plex Pro Human Cytokine Screening Panel (48-Plex). <b>Results:</b> The study group was characterized by a significant increase in the concentration of most of the tested-for proinflammatory cytokines/chemokines/growth factors compared to the control group, with greater amounts of inflammatory factors released from the periosteum covering the titanium implants in the mandible than from the periosteal cells surrounding the titanium implants in the maxilla. <b>Conclusions:</b> Prolonged exposure to titanium miniplates and screws leads to a disturbance of immune homeostasis in the periosteal cells of the maxilla and mandible. The data obtained indicate the need to remove fixations after the bone fragments have healed. <a href="/2077-0383/13/23/7064">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/FR5613GK1W ">State-of-the-Art Innovations in Oral and Maxillofacial Surgery</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 10 pages, 12686 KiB   </span> <a href="/2077-0383/13/23/7063/pdf?version=1732278536" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Title: Is Celiac Trunk Revascularization Necessary After High-Flow Pancreaticoduodenal Arterial Arcades Aneurysm Retrograde Embolization?" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7063">Title: Is Celiac Trunk Revascularization Necessary After High-Flow Pancreaticoduodenal Arterial Arcades Aneurysm Retrograde Embolization?</a> <div class="authors"> by <span class="inlineblock "><strong>Mohamed Salim Jazzar</strong>, </span><span class="inlineblock "><strong>Hicham Kobeiter</strong>, </span><span class="inlineblock "><strong>Mario Ghosn</strong>, </span><span class="inlineblock "><strong>Raphael Amar</strong>, </span><span class="inlineblock "><strong>Youssef Zaarour</strong>, </span><span class="inlineblock "><strong>Athena Galletto Pregliasco</strong>, </span><span class="inlineblock "><strong>Pascal Desgranges</strong>, </span><span class="inlineblock "><strong>Vania Tacher</strong>, </span><span class="inlineblock "><strong>Mostafa El Hajjam</strong> and </span><span class="inlineblock "><strong>Haytham Derbel</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7063; <a href="https://doi.org/10.3390/jcm13237063">https://doi.org/10.3390/jcm13237063</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background and Objective:</b> High-flow pancreaticoduodenal artery (PDA) aneurysms secondary to celiac trunk occlusion or stenosis have a high risk of rupture. Embolization offers a less invasive alternative to surgery. We evaluated the effectiveness and safety of retrograde embolization via the superior mesenteric artery <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7063/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background and Objective:</b> High-flow pancreaticoduodenal artery (PDA) aneurysms secondary to celiac trunk occlusion or stenosis have a high risk of rupture. Embolization offers a less invasive alternative to surgery. We evaluated the effectiveness and safety of retrograde embolization via the superior mesenteric artery of high-flow PDA aneurysms without celiac trunk revascularization. <b>Methods:</b> This retrospective bicentric study included patients who underwent embolization of high-flow PDA aneurysms due to significant celiac trunk stenosis or occlusion. All patients underwent pre-interventional dynamic contrast-enhanced computed tomography. Retrograde embolization was performed using microcoils and/or liquid agents without celiac trunk revascularization. Follow up involved clinical and radiological assessment at one month. Technical and clinical success were evaluated, and complications were categorized as minor or major. <b>Results:</b> Twenty-three patients (mean age 65 ± 14 years; 52% male) were included. Emergency embolization was required in 12 patients (52%). The technical success rate was 100%. Patients were monitored for a median of 16 months. Clinical success was 87%. No hemorrhagic recurrences were observed. Minor complications occurred in two cases. One major complication involved splenic infarction due to glue migration, requiring splenectomy and intensive unit care admission. <b>Conclusions:</b> Retrograde embolization of high-flow PDA aneurysms is effective and safe without needing celiac trunk revascularization. <a href="/2077-0383/13/23/7063">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/2928CF8007 ">Application of Interventional Therapy in Cardiovascular and Cerebrovascular Diseases</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7063/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1527145"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1527145"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1527145" data-cycle-prev="#prev1527145" data-cycle-progressive="#images1527145" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1527145-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07063/article_deploy/html/images/jcm-13-07063-g001-550.jpg?1732278651" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1527145" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1527145-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07063/article_deploy/html/images/jcm-13-07063-g002-550.jpg?1732278654'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1527145-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07063/article_deploy/html/images/jcm-13-07063-g003-550.jpg?1732278656'><p>Figure 3</p></div></script></div></div><div id="article-1527145-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07063/article_deploy/html/images/jcm-13-07063-g001-550.jpg?1732278651" title=" <strong>Figure 1</strong><br/> <p>Abdominal CT after contrast injection at the arterial phase in a coronal view with maximum intensity projection reformatting (<b>A</b>), oblique 3D volume rendering (<b>B</b>), and sagittal 3D volume rendering (<b>C</b>) reconstructions showing a tight stenosis at the origin of the celiac trunk due to compression by the median arcuate ligament (solid arrow, <b>C</b>) and an unruptured aneurysm of the pancreaticoduodenal arcade (dashed arrow, (<b>A</b>–<b>C</b>)), as well as aneurysm’s inflow and outflow tracts (arrowhead, (<b>A</b>,<b>B</b>)).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7063'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07063/article_deploy/html/images/jcm-13-07063-g002-550.jpg?1732278654" title=" <strong>Figure 2</strong><br/> <p>Superior mesenteric angiography at the beginning of the embolization procedure (<b>A</b>) shows an aneurysm in the gastro-duodenal arcade (solid white arrow). After embolization (<b>B</b>), a “sandwich” technique was used to exclude the entry and exit points (arrowheads) as well as the aneurysmal sac, with reinjection into splanchnic territory (dashed white arrows) via other collaterals. Note the use of a 5Fr long sheath (red arrow) and anchoring with a stiff 0.014” guidewire (black arrow) in a non-target branch for better stabilization.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7063'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07063/article_deploy/html/images/jcm-13-07063-g003-550.jpg?1732278656" title=" <strong>Figure 3</strong><br/> <p>Superior mesenteric arteriography showing an aneurysm of the antero-inferior PDA before (solid white arrow/(<b>A</b>)) and after embolization (<b>B</b>) using the “sandwich” technique and exclusion of inflow and outflow arteries (arrowheads/(<b>B</b>)). Note the reinjection via collaterals into splenic and hepatic arteries (dashed arrows). (<b>C</b>) An MRI angiography in the arterial phase with subtraction in a coronal view with maximum intensity projection reformatting, confirming the total exclusion of the aneurysmal sac 1 month after embolization.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7063'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 16 pages, 16653 KiB   </span> <a href="/2077-0383/13/23/7062/pdf?version=1732275065" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Periodontal Breakdown, Orthodontic Movements and Pulpal Ischemia Correlations—A Comparison Between Five Study Methods" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7062">Periodontal Breakdown, Orthodontic Movements and Pulpal Ischemia Correlations—A Comparison Between Five Study Methods</a> <div class="authors"> by <span class="inlineblock "><strong>Radu-Andrei Moga</strong>, </span><span class="inlineblock "><strong>Cristian Doru Olteanu</strong> and </span><span class="inlineblock "><strong>Ada Gabriela Delean</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7062; <a href="https://doi.org/10.3390/jcm13237062">https://doi.org/10.3390/jcm13237062</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: This study assessed the biomechanical behavior of dental pulp and the neuro-vascular bundle/NVB as well as the ischemic risks during orthodontic movements in a gradual horizontal periodontal breakdown, using five methods and aiming to identify the most accurate one. <b>Methods</b>: <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7062/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: This study assessed the biomechanical behavior of dental pulp and the neuro-vascular bundle/NVB as well as the ischemic risks during orthodontic movements in a gradual horizontal periodontal breakdown, using five methods and aiming to identify the most accurate one. <b>Methods</b>: Seventy-two models of second lower premolar (from nine patients) were subjected to 3 N of intrusion, extrusion, rotation, tipping, and translation. Five numerical methods, Tresca, Von Mises/VM, Maximum and Minimum Principal, and hydrostatic pressure were used in a total of 1800 numerical simulations. The results were color-coded projections of the stress areas that were then correlated with maximum physiological hydrostatic pressure/MHP and known clinical biomechanical behavior. <b>Results</b>: During periodontal breakdown, all five methods displayed, for all movements, quantitative stresses lower than MHP, suggesting that 3 N are not inducing any local tissular ischemic risks for the healthy intact tissues. All five methods displayed rotation as the most stressful movement during periodontal breakdown, while translation was the least. The NVB was more exposed to ischemic risks than dental pulp during the periodontal breakdown due to constant tissular deformations. Only VM and Tresca methods showed translation as more prone to expose dental pulp (both coronal and radicular) to ischemic risks (than the other movements) during the periodontal breakdown simulation. However, all five methods showed intrusion and extrusion as more prone to expose the NVB to higher ischemic risks than the other movements during the periodontal breakdown simulation. <b>Conclusions</b>: During periodontal breakdown, Tresca and Von Mises were more accurate, with Tresca being the most accurate of all. <a href="/2077-0383/13/23/7062">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/19ML95R58Z ">Surgical and Non-surgical Endodontics in 2024 and Beyond</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7062/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1527100"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1527100"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1527100" data-cycle-prev="#prev1527100" data-cycle-progressive="#images1527100" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1527100-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07062/article_deploy/html/images/jcm-13-07062-g001-550.jpg?1732275285" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1527100" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1527100-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07062/article_deploy/html/images/jcm-13-07062-g002-550.jpg?1732275289'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1527100-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07062/article_deploy/html/images/jcm-13-07062-g003-550.jpg?1732275294'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1527100-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07062/article_deploy/html/images/jcm-13-07062-g004-550.jpg?1732275298'><p>Figure 4</p></div></script></div></div><div id="article-1527100-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07062/article_deploy/html/images/jcm-13-07062-g001-550.jpg?1732275285" title=" <strong>Figure 1</strong><br/> <p>Mesh model (one of the nine 3D models): (<b>A</b>) 2nd lower right premolar model with 1 mm loss periodontium, (<b>B</b>) 4 mm loss model, (<b>C</b>) 8 mm loss model, (<b>D</b>) 1 mm loss models with applied extrusion and restraining movements base vectors, (<b>E</b>) second lower premolar with the base of the bracket and the NVB and (<b>F</b>) dental pulp and NVB. Applied vectors: (<b>G</b>) intrusion, (<b>H</b>) rotation, (<b>I</b>) tipping, (<b>J</b>) translation, (<b>K</b>) dental pulp and NVB mesh with elements warnings and (<b>L</b>) second lower premolar with mesh elements warnings.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7062'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07062/article_deploy/html/images/jcm-13-07062-g002-550.jpg?1732275289" title=" <strong>Figure 2</strong><br/> <p>Comparative stress distribution displayed by the five methods for 3 N applied force (of one of the nine 3D models), in 1 mm periodontal breakdown and five movements (extrusion, intrusion, rotation, tipping and translation): (<b>A</b>) hydrostatic pressure, (<b>B</b>) Minimum Principal, (<b>C</b>) Maximum Principal, (<b>D</b>) Tresca and (<b>E</b>) Von Mises.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7062'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07062/article_deploy/html/images/jcm-13-07062-g003-550.jpg?1732275294" title=" <strong>Figure 3</strong><br/> <p>Comparative stress distribution displayed by the five methods for 3 N applied force (of one of the nine 3D models), in 4 mm periodontal breakdown and five movements (extrusion, intrusion, rotation, tipping and translation): (<b>A</b>) hydrostatic pressure, (<b>B</b>) Minimum Principal, (<b>C</b>) Maximum Principal, (<b>D</b>) Tresca, (<b>E</b>) Von Mises.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7062'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07062/article_deploy/html/images/jcm-13-07062-g004-550.jpg?1732275298" title=" <strong>Figure 4</strong><br/> <p>Comparative stress distribution displayed by the five methods for 3 N applied force (of one of the nine 3D models), in 8 mm periodontal breakdown and five movements (extrusion, intrusion, rotation, tipping and translation): (<b>A</b>) hydrostatic pressure, (<b>B</b>) Minimum Principal, (<b>C</b>) Maximum Principal, (<b>D</b>) Tresca and (<b>E</b>) Von Mises.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7062'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 8 pages, 451 KiB   </span> <a href="/2077-0383/13/23/7061/pdf?version=1732272344" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Maternal Morbidity Associated with Early Preterm Birth in Low-Risk Singleton Pregnancies" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7061">Maternal Morbidity Associated with Early Preterm Birth in Low-Risk Singleton Pregnancies</a> <div class="authors"> by <span class="inlineblock "><strong>Moti Gulersen</strong>, </span><span class="inlineblock "><strong>Erez Lenchner</strong>, </span><span class="inlineblock "><strong>Alisha Goyal</strong>, </span><span class="inlineblock "><strong>Amos Grunebaum</strong>, </span><span class="inlineblock "><strong>Frank A. Chervenak</strong> and </span><span class="inlineblock "><strong>Eran Bornstein</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7061; <a href="https://doi.org/10.3390/jcm13237061">https://doi.org/10.3390/jcm13237061</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> While neonatal morbidities associated with early preterm birth are known, the risks of maternal morbidities in these births remain unclear. Thus, we set out to assess the risk of maternal morbidities associated with early preterm births. <b>Methods:</b> Retrospective cohort study utilizing the <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7061/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> While neonatal morbidities associated with early preterm birth are known, the risks of maternal morbidities in these births remain unclear. Thus, we set out to assess the risk of maternal morbidities associated with early preterm births. <b>Methods:</b> Retrospective cohort study utilizing the United States (US) Natality Live Birth database from the Centers for Disease Control and Prevention (2016–2021). Low-risk singleton pregnancies were included. High-risk conditions such as out-of-hospital births, fetal anomalies, pregestational and gestational diabetes, and hypertensive disorders of pregnancy were excluded. The rates of several maternal morbidities were compared among three gestational age at birth groups: 23 0/7–27 6/7 (i.e., extreme preterm), 28 0/7–33 6/7 (i.e., early preterm), and 37 0/7–41 6/7 (i.e., term, reference group) weeks. Multivariable logistic regression was used to adjust outcomes for potential confounders. Data were presented as adjusted odds ratios (aORs) with a 95% confidence interval (CI). <b>Results:</b> 18,797,394 live births were analyzed. Extreme and early preterm birth were associated with increased odds of maternal transfusion (aOR 3.32, 95% CI 3.13–3.53 and aOR 2.96, 95% CI 2.86–3.07), uterine rupture (aOR 3.75, 95% CI 3.14–4.48 and aOR 4.13, 95% CI 3.76–4.54), unplanned hysterectomy (aOR 5.60, 95% CI 4.85–6.48 and aOR 5.92, 95% CI 5.47–6.40), and maternal admission to the intensive care unit (ICU, aOR 10.58, 95% CI 9.97–11.54 and aOR 10.13, 95% CI 9.77–10.50) compared to term birth. The odds of third- or fourth-degree perineal lacerations were decreased in both preterm birth groups compared to term birth. <b>Conclusions:</b> In addition to the known prematurity-related neonatal morbidities, extreme and early preterm births also impose a risk for maternal morbidities. Higher odds of maternal transfusion, uterine rupture, unplanned hysterectomy, and maternal admission to the ICU were detected in our cohort. These data should be taken into consideration when caring for patients with preterm births. <a href="/2077-0383/13/23/7061">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Obstetrics_Gynecology">Obstetrics & Gynecology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7061/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1527053-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07061/article_deploy/html/images/jcm-13-07061-g001-550.jpg?1732272417" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1527053-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07061/article_deploy/html/images/jcm-13-07061-g001-550.jpg?1732272417" title=" <strong>Figure 1</strong><br/> <p>Flow diagram illustrating the exclusion process in the study cohort.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7061'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 642 KiB   </span> <a href="/2077-0383/13/23/7060/pdf?version=1732272275" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="The Effect of Bio-Electromagnetic Energy Regulation Therapy on Erectile Dysfunction in Patients with Multiple Sclerosis: A Triple-Blind Randomized Clinical Trial" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7060">The Effect of Bio-Electromagnetic Energy Regulation Therapy on Erectile Dysfunction in Patients with Multiple Sclerosis: A Triple-Blind Randomized Clinical Trial</a> <div class="authors"> by <span class="inlineblock "><strong>Abdulaziz Ali Y. Alzharani</strong>, </span><span class="inlineblock "><strong>Ali M. Alshami</strong>, </span><span class="inlineblock "><strong>Turki Abualait</strong>, </span><span class="inlineblock "><strong>Hatem Al Azman</strong>, </span><span class="inlineblock "><strong>Foziah Jabbar Alshamrani</strong>, </span><span class="inlineblock "><strong>Yahya Hilal Alzahrani</strong> and </span><span class="inlineblock "><strong>Youssef A. Althobaiti</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7060; <a href="https://doi.org/10.3390/jcm13237060">https://doi.org/10.3390/jcm13237060</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Objectives</b>: To evaluate the effect of bio-electromagnetic energy regulation (BEMER) therapy on erectile dysfunction (ED) in patients with multiple sclerosis (MS). <b>Methods:</b> A triple-blind randomized clinical trial was conducted in two different centers. Fifty-two male participants with MS were randomly allocated into <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7060/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Objectives</b>: To evaluate the effect of bio-electromagnetic energy regulation (BEMER) therapy on erectile dysfunction (ED) in patients with multiple sclerosis (MS). <b>Methods:</b> A triple-blind randomized clinical trial was conducted in two different centers. Fifty-two male participants with MS were randomly allocated into two groups. Patients received either three weeks of BEMER with pelvic floor exercises or sham BEMER with pelvic floor exercises. The primary measure was the International Index of Erectile Function—Erectile Function (IIEF-EF). Secondary measures included the Sexual Health Inventory for Men (SHIM), Erection Hardness Scale (EHS), Arizona Sexual Experience Scale (AXES), Modified Fatigue Impact Scale (MFIS), and Multiple Sclerosis, Intimacy, and Sexuality Questionnaire (MSISQ-19). <b>Results</b>: Compared to the sham BEMER group, the BEMER group showed better improvements in the IIEF-EF (mean difference [MD]: −6.9, <i>p</i> < 0.001), SHIM (MD: −6.1, <i>p</i> < 0.001), EHS (MD: −0.4, <i>p</i> = 0.022), AXES (MD: 2.9, <i>p</i> = 0.030), MSISQ-19 (MD: 15.0, <i>p</i> < 0.001), and MFIS (MD: 31.0, <i>p</i> < 0.001). <b>Conclusions</b>: BEMER therapy improved erectile function and sexual satisfaction and reduced fatigue in patients with MS after three weeks of intervention. Long-term follow-up studies are warranted to ascertain the sustained benefits of BEMER therapy for MS-related ED. <a href="/2077-0383/13/23/7060">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Reproductive_Medicine_Andrology">Reproductive Medicine & Andrology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7060/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1527055"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1527055"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1527055" data-cycle-prev="#prev1527055" data-cycle-progressive="#images1527055" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1527055-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07060/article_deploy/html/images/jcm-13-07060-g001-550.jpg?1732272344" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1527055" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1527055-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07060/article_deploy/html/images/jcm-13-07060-g002-550.jpg?1732272346'><p>Figure 2</p></div></script></div></div><div id="article-1527055-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07060/article_deploy/html/images/jcm-13-07060-g001-550.jpg?1732272344" title=" <strong>Figure 1</strong><br/> <p>(<b>A</b>) BEMER control unit, (<b>B</b>) B. Spot. (<b>C</b>) Full-body mattress.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7060'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07060/article_deploy/html/images/jcm-13-07060-g002-550.jpg?1732272346" title=" <strong>Figure 2</strong><br/> <p>Flowchart of participants throughout randomized clinical trial. PFMT: pelvic floor muscle training.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7060'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1527039" aria-controls="drop-supplementary-1527039" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1527039" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7059/s1?version=1732271395"> Supplementary File 1 (ZIP, 259 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 9 pages, 1402 KiB   </span> <a href="/2077-0383/13/23/7059/pdf?version=1732271395" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Changes in the Epidemiology of Thoracic and Cardiovascular Diseases in Korea During the COVID-19 Pandemic: A Nationwide Analysis" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7059">Changes in the Epidemiology of Thoracic and Cardiovascular Diseases in Korea During the COVID-19 Pandemic: A Nationwide Analysis</a> <div class="authors"> by <span class="inlineblock "><strong>Jung Ho Park</strong>, </span><span class="inlineblock "><strong>Hong Kyu Lee</strong>, </span><span class="inlineblock "><strong>Hyoung Soo Kim</strong>, </span><span class="inlineblock "><strong>Kunil Kim</strong>, </span><span class="inlineblock "><strong>Yong Joon Ra</strong> and </span><span class="inlineblock "><strong>Jeong Wook Kang</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7059; <a href="https://doi.org/10.3390/jcm13237059">https://doi.org/10.3390/jcm13237059</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> There is limited evidence regarding the impact of the coronavirus disease 2019 (COVID-19) pandemic on the epidemiology of thoracic and cardiovascular diseases. This study aimed to investigate changes in medical visits for these conditions during the COVID-19 pandemic. <b>Methods:</b> We analyzed the <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7059/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> There is limited evidence regarding the impact of the coronavirus disease 2019 (COVID-19) pandemic on the epidemiology of thoracic and cardiovascular diseases. This study aimed to investigate changes in medical visits for these conditions during the COVID-19 pandemic. <b>Methods:</b> We analyzed the entire Korean population (~50 million) for monthly medical visits for 15 common thoracic and cardiovascular conditions, including pneumothorax, large bullae, lung cancer, esophageal cancer, thymoma, empyema, mediastinitis, esophageal rupture, multiple rib fractures, hemothorax, rib mass, varicose vein, pectus excavatum, aortic dissection, aortic aneurysm, and valve disease from January 2019 to December 2021. Data were obtained from the Korean National Health Insurance Service using the International Classification of Disease (ICD)-10 codes. Variations in the mean monthly medical visits of 15 frequent thoracic and cardiovascular diseases before and during the COVID-19 pandemic were compared using the Mann–Whitney U test, while changes in variance were assessed using Levene’s test. <b>Results:</b> The mean monthly number of medical visits for pneumothorax and large bullae significantly decreased during the COVID-19 pandemic compared to before the pandemic (by 10.1% and 12.8%; both <i>p</i> < 0.001). On the contrary, there was a significant increase in the mean monthly counts of medical visits for lung cancer, esophageal cancer, thymoma, and valve disease diagnosis (by 6.6%, 5.3%, 8.8%, and 5.0%, respectively; all <i>p</i> < 0.05). <b>Conclusions:</b> In Korea, the number of diagnosed cases of pneumothorax significantly decreased during the COVID-19 pandemic compared to before COVID-19, while diagnoses of thoracic cancers and valve disease increased. <a href="/2077-0383/13/23/7059">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/GR4ZB7M1L1 ">Clinical Consequences of COVID-19: 2nd Edition</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7059/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1527039-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07059/article_deploy/html/images/jcm-13-07059-g001-550.jpg?1732271516" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1527039-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07059/article_deploy/html/images/jcm-13-07059-g001-550.jpg?1732271516" title=" <strong>Figure 1</strong><br/> <p>Monthly incidence of thoracic diseases during 2019, 2020, and 2021.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7059'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 14 pages, 6295 KiB   </span> <a href="/2077-0383/13/23/7058/pdf?version=1732275593" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Scratch-Based Isolation of Primary Cells (SCIP): A Novel Method to Obtain a Large Number of Human Dental Pulp Cells Through One-Step Cultivation" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7058">Scratch-Based Isolation of Primary Cells (SCIP): A Novel Method to Obtain a Large Number of Human Dental Pulp Cells Through One-Step Cultivation</a> <div class="authors"> by <span class="inlineblock "><strong>Yuki Kiyokawa</strong>, </span><span class="inlineblock "><strong>Masahiko Terajima</strong>, </span><span class="inlineblock "><strong>Masahiro Sato</strong>, </span><span class="inlineblock "><strong>Emi Inada</strong>, </span><span class="inlineblock "><strong>Yuria Hori</strong>, </span><span class="inlineblock "><strong>Ryo Bando</strong>, </span><span class="inlineblock "><strong>Yoko Iwase</strong>, </span><span class="inlineblock "><strong>Naoko Kubota</strong>, </span><span class="inlineblock "><strong>Tomoya Murakami</strong>, </span><span class="inlineblock "><strong>Hiroko Tsugane</strong>, </span><span class="inlineblock "><strong>Satoshi Watanabe</strong>, </span><span class="inlineblock "><strong>Takahiro Sonomura</strong>, </span><span class="inlineblock "><strong>Miho Terunuma</strong>, </span><span class="inlineblock "><strong>Takeyasu Maeda</strong>, </span><span class="inlineblock "><strong>Hirofumi Noguchi</strong> and </span><span class="inlineblock "><strong>Issei Saitoh</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7058; <a href="https://doi.org/10.3390/jcm13237058">https://doi.org/10.3390/jcm13237058</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Dental pulp (DP) is a connective tissue composed of various cell types, including fibroblasts, neurons, adipocytes, endothelial cells, and odontoblasts. It contains a rich supply of pluripotent stem cells, making it an important resource for cell-based regenerative medicine. However, current stem cell <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7058/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Dental pulp (DP) is a connective tissue composed of various cell types, including fibroblasts, neurons, adipocytes, endothelial cells, and odontoblasts. It contains a rich supply of pluripotent stem cells, making it an important resource for cell-based regenerative medicine. However, current stem cell collection methods rely heavily on the enzymatic digestion of dissected DP tissue to isolate and propagate primary cells, which often results in low recovery rates and reduced cell survival, particularly from deciduous teeth. <b>Methods:</b> We developed a novel and efficient method to obtain a sufficient number of cells through a one-step cultivation process of isolated DP. After the brief digestion of DP with proteolytic enzymes, it was scratched onto a culture dish and cultured in a suitable medium. By day 2, the cells began to spread radially from DP, and by day 10, they reached a semi-confluent state. Cells harvested through trypsinization consistently yielded over 1 million cells, and after re-cultivation, the cells could be propagated for more than ten passages. <b>Results:</b> The proliferative and differentiation capacities of the cells after the 10th passage were comparable to those from the first passage. The cells expressed alkaline phosphatase as an undifferentiation marker. Similarly, they also maintained the constitutive expression of stem cell-specific markers and differentiation-related markers, even after the 10th passage. <b>Conclusions:</b> This method, termed “scratch-based isolation of primary cells from human dental pulps (SCIP)”, enables the efficient isolation of a large number of DP cells with minimal equipment and operator variability, while preserving cell integrity. Its simplicity, high success rate, and adaptability for patients with genetic diseases make it a valuable tool for regenerative medicine research and clinical applications. <a href="/2077-0383/13/23/7058">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/C10B32QQ6T ">JSOPB 2023–2024 Congress Special Issue—Update on Organ Preservation and Transplantation</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7058/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1527014"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1527014"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1527014" data-cycle-prev="#prev1527014" data-cycle-progressive="#images1527014" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1527014-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g001-550.jpg?1732275827" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1527014" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1527014-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g002-550.jpg?1732275829'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1527014-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g003-550.jpg?1732275832'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1527014-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g004-550.jpg?1732275835'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1527014-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g005-550.jpg?1732275837'><p>Figure 5</p></div> --- <div class='openpopupgallery' data-imgindex='5' data-target='article-1527014-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g006-550.jpg?1732275841'><p>Figure 6</p></div> --- <div class='openpopupgallery' data-imgindex='6' data-target='article-1527014-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g007-550.jpg?1732275843'><p>Figure 7</p></div></script></div></div><div id="article-1527014-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g001-550.jpg?1732275827" title=" <strong>Figure 1</strong><br/> <p>The conventional method and a new method (scratch-based isolation of primary cells from human dental pulps [SCIP]) were used for the isolation of dental pulp (DP) cells. (<b>A</b>) The conventional method was described by Gronthos et al. [<a href="#B27-jcm-13-07058" class="html-bibr">27</a>,<a href="#B28-jcm-13-07058" class="html-bibr">28</a>]. DP tissues were harvested from teeth, minced, and subjected to enzymatic digestion. The cells were then filtered through a cell strainer, centrifuged, and collected. (<b>B</b>) In the SCIP method used in this study, harvested DP tissues were minced and enzymatically digested for a short period. They were then scratched onto the surface of a plastic dish containing the growth medium. This method enabled us to obtain cells repeatedly, owing to the tight attachment of DP tissues to the bottom of the dish. After obtaining cells by trypsinization, the dish was replenished with fresh medium. This allowed cells to exhibit outgrowth from the DP tissues, making it possible to harvest them again. We call this repeated cell collection “repeated passage (RP)”. (<b>C</b>) The DP tissue was scraped from the bottom of the culture dish. The scar made by the scalpel on the dish surface is shown by an arrow. Arrowheads indicate DP tissue. Scale bar, 50 μm.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7058'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g002-550.jpg?1732275829" title=" <strong>Figure 2</strong><br/> <p>Cell proliferation in scraped DP tissues attached to the culture dish surface. (<b>A</b>) Image of the scraped DP tissues cultured in MEMα/10% FBS. Images were captured on the day of scratching (designated day 0). (<b>B</b>) Image of scraped DP tissue cultured on day 2. Cell outgrowth (arrows) was first observed. (<b>C</b>) Image of scraped DP tissues cultured on day 6. Cells proliferated radially around the DP tissue. (<b>D</b>) Image of scraped DP tissue cultured on day 10. The cells were allowed to reach confluence. Scale bar, 100 μm. DP cells from No. 12 were used (see <a href="#jcm-13-07058-t002" class="html-table">Table 2</a> for details).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7058'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g003-550.jpg?1732275832" title=" <strong>Figure 3</strong><br/> <p>Time required to reach ≥ 80% confluence following repeated passage (RP). (<b>A</b>) Cells reached confluence on day 5 after RP1. (<b>B</b>) Cells reached confluence on day 6 after RP2. (<b>C</b>) Cells reached confluence on day 4 after RP4 treatment. (<b>D</b>) Cells reached confluence on day 4 after RP6 treatment. (<b>E</b>) Cells reached confluence on day 5 after RP10 treatment. (<b>F</b>) Cells reached confluence on day 9 of RP15 treatment. Scale bar, 100 μm. RP, repeated passage. DP cells from No. 12 were used (see <a href="#jcm-13-07058-t002" class="html-table">Table 2</a> for details).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7058'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g004-550.jpg?1732275835" title=" <strong>Figure 4</strong><br/> <p>Subculture after repeated passage (RP). The cells obtained at (<b>A</b>) RP1, (<b>B</b>) RP6, (<b>C</b>) RP10, and (<b>D</b>) RP15 were re-plated onto 60 mm gelatin-coated culture dishes, and reached confluence 2 days after seeding. However, the number of cells derived from RP15 cells was low. Scale bar, 100 μm. DP cells from No. 12 were used (see <a href="#jcm-13-07058-t002" class="html-table">Table 2</a> for details).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7058'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g005-550.jpg?1732275837" title=" <strong>Figure 5</strong><br/> <p>Cytochemical staining for alkaline phosphatase. (<b>A</b>,<b>C</b>) ALP-stained cells with phase images. Cells were subjected to ALP staining three days after RP2 and RP9. (<b>B</b>,<b>D</b>) High-magnification-rate phase images. Scale bar, 100 μm. DP cells from No. 12 were used (see <a href="#jcm-13-07058-t002" class="html-table">Table 2</a> for details).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7058'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g006-550.jpg?1732275841" title=" <strong>Figure 6</strong><br/> <p>RT-PCR analysis of stem cell-related gene expression in HDDPCs. The RT-PCR products obtained from HDDPCs that underwent four cell passages after PR2 are designated RP2 plus P4. Similarly, cells that underwent 15 passages after PR2 and 4 passages after RP9 or 15 passages after RP9 were designated as RP2 plus P15, RP9 plus P4, and RP9 plus P15, respectively. GAPDH, glyceraldehyde-3-phosphate dehydrogenase; OCT3/4, octamer-binding protein 3/4; SOX2, SRY-box transcription factor 2; NANOG, Nanog homeobox; ALP, Alkaline phosphatase; TUBULIN, Tubulin; IGF1, insulin-like growth factor 1; NESIN, nestin; DSPP, dentin sialophosphoprotein; OCN, osteocalcin; FSP1, fibroblast-specific protein 1; CD90, cluster of differentiation 90; MSX1, Msh homeobox 1; MSX2, Msh homeobox 2; ABCG, ATP-binding cassette subfamily G; -RT, negative control (water was used for PCR). DP cells from No. 12 were used (see <a href="#jcm-13-07058-t002" class="html-table">Table 2</a> for details).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7058'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07058/article_deploy/html/images/jcm-13-07058-g007-550.jpg?1732275843" title=" <strong>Figure 7</strong><br/> <p>Immunocytochemical analysis of HDDPCs derived from RP2 plus P4 and RP9 plus P4 using anti-SSEA-1 (<b>A</b>) and anti-OCT3/4 antibodies (<b>B</b>). DAPI was used to visualize nuclear DNA. Bar, 100 μm. DP cells from No. 12 were used (see <a href="#jcm-13-07058-t002" class="html-table">Table 2</a> for details).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7058'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 15 pages, 3694 KiB   </span> <a href="/2077-0383/13/23/7057/pdf?version=1732271041" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Comparative Analysis of M4CXR, an LLM-Based Chest X-Ray Report Generation Model, and ChatGPT in Radiological Interpretation" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7057">Comparative Analysis of M4CXR, an LLM-Based Chest X-Ray Report Generation Model, and ChatGPT in Radiological Interpretation</a> <div class="authors"> by <span class="inlineblock "><strong>Ro Woon Lee</strong>, </span><span class="inlineblock "><strong>Kyu Hong Lee</strong>, </span><span class="inlineblock "><strong>Jae Sung Yun</strong>, </span><span class="inlineblock "><strong>Myung Sub Kim</strong> and </span><span class="inlineblock "><strong>Hyun Seok Choi</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7057; <a href="https://doi.org/10.3390/jcm13237057">https://doi.org/10.3390/jcm13237057</a> - 22 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> This study investigated the diagnostic capabilities of two AI-based tools, M4CXR (research-only version) and ChatGPT-4o, in chest X-ray interpretation. M4CXR is a specialized cloud-based system using advanced large language models (LLMs) for generating comprehensive radiology reports, while ChatGPT, built on the GPT-4 <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7057/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> This study investigated the diagnostic capabilities of two AI-based tools, M4CXR (research-only version) and ChatGPT-4o, in chest X-ray interpretation. M4CXR is a specialized cloud-based system using advanced large language models (LLMs) for generating comprehensive radiology reports, while ChatGPT, built on the GPT-4 architecture, offers potential in settings with limited radiological expertise. <b>Methods:</b> This study evaluated 826 anonymized chest X-ray images from Inha University Hospital. Two experienced radiologists independently assessed the performance of M4CXR and ChatGPT across multiple diagnostic parameters. The evaluation focused on diagnostic accuracy, false findings, location accuracy, count accuracy, and the presence of hallucinations. Interobserver agreement was quantified using Cohen’s kappa coefficient. <b>Results:</b> M4CXR consistently demonstrated superior performance compared to ChatGPT across all evaluation metrics. For diagnostic accuracy, M4CXR achieved approximately 60–62% acceptability ratings compared to ChatGPT’s 42–45%. Both systems showed high interobserver agreement rates, with M4CXR generally displaying stronger consistency. Notably, M4CXR showed better performance in anatomical localization (76–77.5% accuracy) compared to ChatGPT (36–36.5%) and demonstrated fewer instances of hallucination. <b>Conclusions:</b> The findings highlight the complementary potential of these AI technologies in medical diagnostics. While M4CXR shows stronger performance in specialized radiological analysis, the integration of both systems could potentially optimize diagnostic workflows. This study emphasizes the role of AI in augmenting human expertise rather than replacing it, suggesting that a combined approach leveraging both AI capabilities and clinical judgment could enhance patient care outcomes. <a href="/2077-0383/13/23/7057">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Nuclear_Medicine_Radiology">Nuclear Medicine & Radiology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7057/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1527018"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1527018"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1527018" data-cycle-prev="#prev1527018" data-cycle-progressive="#images1527018" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1527018-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g001-550.jpg?1732271161" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1527018" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1527018-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g002-550.jpg?1732271162'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1527018-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g003-550.jpg?1732271163'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1527018-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g004-550.jpg?1732271164'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1527018-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g005-550.jpg?1732271165'><p>Figure 5</p></div> --- <div class='openpopupgallery' data-imgindex='5' data-target='article-1527018-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g006-550.jpg?1732271167'><p>Figure 6</p></div> --- <div class='openpopupgallery' data-imgindex='6' data-target='article-1527018-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g007-550.jpg?1732271168'><p>Figure 7</p></div> --- <div class='openpopupgallery' data-imgindex='7' data-target='article-1527018-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g008-550.jpg?1732271169'><p>Figure 8</p></div></script></div></div><div id="article-1527018-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g001-550.jpg?1732271161" title=" <strong>Figure 1</strong><br/> <p>Architecture of the M4CXR. (<b>a</b>) Following the framework of LLaVA (Large Language and Vision Assistant), M4CXR consists of a vision encoder, a projector, and an LLM. (<b>b</b>) Schema for constructing a CXR visual instruction-following dataset.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7057'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g002-550.jpg?1732271162" title=" <strong>Figure 2</strong><br/> <p>Overview of the multi-task capabilities of M4CXR.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7057'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g003-550.jpg?1732271163" title=" <strong>Figure 3</strong><br/> <p>A schematic image of M4CXR in research use.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7057'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g004-550.jpg?1732271164" title=" <strong>Figure 4</strong><br/> <p>Diagnostic accuracy of M4CXR and GPT4o.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7057'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g005-550.jpg?1732271165" title=" <strong>Figure 5</strong><br/> <p>False findings of M4CXR and GPT4o.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7057'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g006-550.jpg?1732271167" title=" <strong>Figure 6</strong><br/> <p>Location inaccuracy of M4CXR and GPT4o.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7057'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g007-550.jpg?1732271168" title=" <strong>Figure 7</strong><br/> <p>Count inaccuracy of M4CXR and GPT4o.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7057'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07057/article_deploy/html/images/jcm-13-07057-g008-550.jpg?1732271169" title=" <strong>Figure 8</strong><br/> <p>Hallucination of M4CXR and GPT4o.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7057'>Full article</a></strong> "></a></div> </div> </div> </div> </div> <div class="generic-item last-item"> <a class="bold" href="/search?q=&journal=jcm&sort=pubdate&page_count=50">More Articles...</a> </div> </div> </div> </div> <div id="left-column" class="content__column 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max-width: 100%; height: auto;" src="https://pub.mdpi-res.com/img/misc/event_1728720430388.jpg?1732286508" border="0"></a></div> <div class="generic-item"><span class="text-information"> 19–20 March 2025 </span><a href="/journal/jcm/events/17282" class="title-link bold">[IOCCR 2025] Present your work at the 1st International Online Conference on Clinical Reports</a><a href="/journal/jcm/events/17282"><img style="margin: 5px 0; max-width: 100%; height: auto;" src="https://pub.mdpi-res.com/img/misc/event_1715877976135.jpg?1732286508" border="0"></a></div> <div class="generic-item"><span class="text-information"> 29 November–1 December 2024 </span><a href="/journal/jcm/events/17527" class="title-link bold">21st European Angiology Days—International Vascular Medicine Academic Yearly Conference</a><a href="/journal/jcm/events/17527"><img style="margin: 5px 0; max-width: 100%; height: auto;" src="https://pub.mdpi-res.com/img/misc/event_1722387365423.jpg?1732286508" border="0"></a></div> <div class="generic-item last-item"> <a href="/journal/jcm/events" class="bold">More Conferences...</a><br/> </div> </div> </div> <div class="content__container selected-special-issues"> <div class="custom-accordion-for-small-screen-link"> <h2>Special Issues</h2> </div> <div class="custom-accordion-for-small-screen-content show-for-medium-up"> <div class="generic-item button-type no-border"> <a class="button button--color button--full-width submit-manuscript" href="/journalproposal/sendproposalspecialissue/jcm" data-path="/journal/jcm"> Propose a Special Issue </a> </div> <div class="generic-item"><div><span class="text-information times"> Special Issue in </span><span class="text-information italics times">JCM</span></div><a class="title-link bold" href="/journal/jcm/special_issues/91TCP5E3S2"> Clinical Management of Patients with Heart Failure </a><span class="text-information color-grey-dark">Guest Editors: Cristina Tudoran, Larisa Anghel<br/></span><span class="text-information highlight">Deadline: 24 November 2024</span></div> <div class="generic-item"><div><span class="text-information times"> Special Issue in </span><span class="text-information italics times">JCM</span></div><a class="title-link bold" href="/journal/jcm/special_issues/T76E9W6998"> Thoracic Surgery: Current Practice and Future Directions </a><span class="text-information color-grey-dark">Guest Editor: Dania Nachira<br/></span><span class="text-information highlight">Deadline: 24 November 2024</span></div> <div class="generic-item"><div><span class="text-information times"> Special Issue in </span><span class="text-information italics times">JCM</span></div><a class="title-link bold" href="/journal/jcm/special_issues/V42YYSP707"> Stroke Diagnosis and Outcome Prediction </a><span class="text-information color-grey-dark">Guest Editor: Ramin Zand<br/></span><span class="text-information highlight">Deadline: 25 November 2024</span></div> <div class="generic-item"><div><span class="text-information times"> Special Issue in </span><span class="text-information italics times">JCM</span></div><a class="title-link bold" href="/journal/jcm/special_issues/Endometrial_Cancer_JCM"> Update on Endometrial Cancer: From Diagnosis to Treatment </a><span class="text-information color-grey-dark">Guest Editor: Simone Ferrero<br/></span><span class="text-information highlight">Deadline: 25 November 2024</span></div> <div class="generic-item last-item"> <a href="/journal/jcm/special_issues" class="bold">More Special Issues</a> </div> </div> </div> <div class="content__container selected-special-issues"> <div class="custom-accordion-for-small-screen-link"> <h2>Topical Collections</h2> </div> <div class="custom-accordion-for-small-screen-content show-for-medium-up"> <div class="generic-item"><div><span class="text-information times"> Topical Collection in </span><span class="text-information italics times">JCM</span></div><a class="title-link bold" href="/journal/jcm/topical_collections/9IZ8GJ28F8"> Ocular Manifestations of Systemic Diseases </a><span class="text-information color-grey-dark">Collection Editor: Anat Galor<br/></span></div> <div class="generic-item"><div><span class="text-information times"> Topical Collection in </span><span class="text-information italics times">JCM</span></div><a class="title-link bold" href="/journal/jcm/topical_collections/coronavirus_presentation_pathogenesis_and_treatment"> Coronavirus Disease 2019: Clinical Presentation, Pathogenesis and Treatment </a><span class="text-information color-grey-dark">Collection Editor: Vito Racanelli<br/></span></div> <div class="generic-item"><div><span class="text-information times"> Topical Collection in </span><span class="text-information italics times">JCM</span></div><a class="title-link bold" href="/journal/jcm/topical_collections/Practice_Research_Clinical_Pharmacology"> Practice and Research in Clinical Pharmacology </a><span class="text-information color-grey-dark">Collection Editors: Antonio J. Carcas-Sansuán, Alberto M. Borobia Pérez<br/></span></div> <div class="generic-item"><div><span class="text-information times"> Topical Collection in </span><span class="text-information italics times">JCM</span></div><a class="title-link bold" href="/journal/jcm/topical_collections/research_hepatology"> Clinical Research in Hepatology </a><span class="text-information color-grey-dark">Collection Editor: Yulia A. Nevzorova<br/></span></div> <div class="generic-item last-item"> <a href="/journal/jcm/topical_collections" class="bold">More Topical Collections</a> </div> </div> </div> <div class="column-padding"></div> </div> </div> </div> </section> <div id="footer"> <div class="journal-info"> <span> <em><a class="Var_JournalInfo" href="/journal/jcm">J. Clin. 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