Discovery & exploratory research

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menu-item menu-item-type-custom menu-item-object-custom menu-item-21421 list-inline-item"><a href="https://powerofantibiotics.org/" itemprop="url"><span itemprop='name' class='nav-items'>PowerOfAntibiotics</span></a></li> </ul></div> </div> </div> </div> </nav> </header> <div id="main-container" class="hyphenate"> <div class="gardp-marquee"> <p>World AMR Awareness Week - 18 to 24 November 2024. Educate. Advocate. Act now.</p> </div><main id="content" role="main"> <section class="hero" style="background: linear-gradient(0deg, rgba(0,0,0,0.4), rgba(0,0,0,0.4)), url(https://gardp.org/wp-content/uploads/2023/02/AdobeStock_401561723-1-2000x939.png.webp) no-repeat center ; background-size: cover;; background-position: 58.5% 59.27%"> <div class="container"> <div class="row"> <div class="col-12 parallax-wrap content"> <div class="title mt-50"> <h1 style="text-align: center;"><span class="h1-big">Discovery & Exploratory </span></h1><h1 style="text-align: center;"><span class="h1-big">Research</span></h1> </div> <div class="btn-wrap mt-4 d-flex justify-content-center"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: 50%; left: 50%; z-index: 5;"> <img src="" alt=""/> </div> </div> </div> <div class="col-md-5 parallax-wrap parallax-wrap-desktop d-none d-md-block"> </div> </div> </div> </section> <section class="plain-text readmore-text" style="background: linear-gradient(0deg, rgba(13,31,48,0.4), rgba(13,31,48,0.4)), url(https://gardp.org/wp-content/uploads/2023/02/AdobeStock_137979283.jpeg.webp) no-repeat center ; background-size: cover;" id=""> <div class="container"> <div class="row d-none d-md-flex"> <div class="col-6 col-md-9 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white h2"></h1> </div> </div> </div> <div class="row"> <div class="col-12 col-md-9 parallax-wrap"> <div class="offset-md-1"> <div class="text-subtitle"> <h4><span class="white"><a href="https://www.who.int/news/item/15-04-2021-global-shortage-of-innovative-antibiotics-fuels-emergence-and-spread-of-drug-resistance" target="_blank" rel="noopener">Growing drug resistance is outpacing the development of antibiotics for the most difficult-to-treat infections</a>. What is needed are not just new or more antibiotics, but rather innovative antibiotics that target resistant and deadly pathogens. Producing such antibiotics starts with the earliest stage of drug development: discovery and exploratory research. GARDP is harnessing 21st-century technologies and engaging in strategic partnerships to advance the discovery of compounds that have the potential to become the innovative antibiotics of the future.</span></h4> </div> </div> <div class="offset-md-1 btn-wrap mt-50-25"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </section> <section class="facts" style="background-color: #ffffff" id=""> <div class="container"> <div class="row"> <div class="col-12 col-lg-6"> <h1 class="title mb-50 color-b h2">Programme goals</h1> </div> </div> <div class="numbers-items row parallax-wrap"> <div class="item col-12 col-xl-6"> <div class="img-wrapper"> <img width="540" height="220" src="https://gardp.org/wp-content/uploads/2023/02/DER-Goal-1.jpg.webp" class="attachment-img900 size-img900" alt="Der Goal 1" style="object-position: 50% 50%" decoding="async" fetchpriority="high" srcset="https://gardp.org/wp-content/uploads/2023/02/DER-Goal-1.jpg.webp 540w, https://gardp.org/wp-content/uploads/2023/02/DER-Goal-1-500x204.jpg.webp 500w" sizes="(max-width: 540px) 100vw, 540px"/> </div> <div class="number-wrap"> <span class="h3 w-80 color-c">Goal 1</span> </div> <div class="description color-a"><p>Use novel technologies and the best science to find new substances (compounds) with potential for drug development</p> </h1></div> </div> <div class="item col-12 col-xl-6"> <div class="img-wrapper"> <img width="540" height="220" src="https://gardp.org/wp-content/uploads/2023/02/DER-Goal-2.png.webp" class="attachment-img900 size-img900" alt="Der Goal 2" style="object-position: 50% 50%" decoding="async" srcset="https://gardp.org/wp-content/uploads/2023/02/DER-Goal-2.png.webp 540w, https://gardp.org/wp-content/uploads/2023/02/DER-Goal-2-500x204.png.webp 500w" sizes="(max-width: 540px) 100vw, 540px"/> </div> <div class="number-wrap"> <span class="h3 w-80 color-c">Goal 2</span> </div> <div class="description color-a"><p>Knowledge generation and sharing discoveries</p> </h1></div> </div> <div class="col-12 parallax-wrap-desktop d-none d-md-block"> </div> <div class="col-12 parallax-wrap-mobile d-block d-md-none"> </div> </div> <div class="row justify-content-center"> <div class="btn-wrap"> <div class="btn-wrap mt-4 d-flex justify-content-center"> <a href="https://gardp.org/gardp-strategy-2024-2028/" target="_blank" class="btn btn-color-c white">LEARN MORE</a> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #e4f2ff" id=""> <div class="container"> <div class="row flex-row-reverse"> <div class="col-lg-6"> <div class="text-box"> <h3><span class="color-b">“The discovery of new antibiotic compounds has changed massively over the past few decades. Science has become much more collaborative and has seen the introduction of advanced, new technologies and computational power. There is great potential to discover compounds that could become the life-saving antibiotics of the future.”</span></h3><p> </p><p>– Laura Piddock, Scientific Director, GARDP</p><p> </p><h6 style="text-align: left;"><span class="metatext"> Researchers operate a screening platform located in the Biosafety Level 2 laboratory of Institut Pasteur Korea (Credit: Institut Pasteur Korea)</span></h6> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <img width="900" height="675" src="https://gardp.org/wp-content/uploads/2022/10/Researchers_BSL2_operation-e1667866444815-900x675.jpg.webp" class="image-content m-0 glow-white" alt="Researchers Bsl2 Operation" decoding="async" srcset="https://gardp.org/wp-content/uploads/2022/10/Researchers_BSL2_operation-e1667866444815-900x675.jpg.webp 900w, https://gardp.org/wp-content/uploads/2022/10/Researchers_BSL2_operation-e1667866444815-500x375.jpg.webp 500w, https://gardp.org/wp-content/uploads/2022/10/Researchers_BSL2_operation-e1667866444815-1440x1080.jpg.webp 1440w, https://gardp.org/wp-content/uploads/2022/10/Researchers_BSL2_operation-e1667866444815-2000x1500.jpg.webp 2000w" sizes="(max-width: 900px) 100vw, 900px"/> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #ffffff" id=""> <div class="container"> <div class="row"> <div class="col-lg-6"> <h1 class="title mb-50 color-b h2">The drug discovery and development funnel</h1> <div class="text-box"> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <img width="900" height="719" src="https://gardp.org/wp-content/uploads/2023/03/DER-funnel-2023-900x719.png.webp" class="image-content m-0 glow-white" alt="Der Funnel 2023" decoding="async" srcset="https://gardp.org/wp-content/uploads/2023/03/DER-funnel-2023-900x719.png.webp 900w, https://gardp.org/wp-content/uploads/2023/03/DER-funnel-2023-500x399.png.webp 500w, https://gardp.org/wp-content/uploads/2023/03/DER-funnel-2023-1440x1150.png.webp 1440w, https://gardp.org/wp-content/uploads/2023/03/DER-funnel-2023-2000x1597.png.webp 2000w" sizes="(max-width: 900px) 100vw, 900px"/> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="0" style=" top: 50%; left: 50%; width: 700px; z-index: 5;"> <img src="" alt=""/> </div> </div> </div> </div> </div> </div> </section> <section class="cta" style="background: linear-gradient(0deg, rgba(13,31,48,0.4), rgba(13,31,48,0.4)), url(https://gardp.org/wp-content/uploads/2023/02/AdobeStock_137979283.jpeg.webp) no-repeat center fixed; background-size: cover;" id=""> <div class="container"> <div class="row"> <div class="col-lg-6"> <h1 class="title mb-4 white default">Current projects</h1> <div class="center-text-custom"></div> </div> <div class="offset-lg-3 col-lg-3 d-flex align-items-center justify-content-start justify-content-md-center"> <div class="btn-wrap"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #e4f2ff" id=""> <div class="container"> <div class="row"> <div class="col-lg-6"> <h1 class="title mb-50 color-b h2">High-throughput screening and profiling compounds with activity against drug-resistant bacteria</h1> <div class="text-box"> <p><span style="font-weight: 400;">GARDP has screened thousands of compounds (i.e., substances synthesised in laboratory) and natural products (that are produced by microbes) for antibiotic activity. The goal is to identify compounds with the potential either to become a new antibiotic, or to restore activity of an existing antibiotic that has been affected by drug resistance. </span></p> <div class="accordion"> <div class="accordion-component" id="accordionExample-264959208"> <div class="card"> <div class="" id="headingOne"> <h2 class="mb-0"> <button class="btn btn-link btn-block text-left collapsed" type="button" data-toggle="collapse" data-target="#collapseOne-264959208" aria-expanded="true" aria-controls="collapseOne-264959208"> <svg width="22" height="15" viewBox="0 0 22 15" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M1 1L11 13.3077L21 1" stroke="#0D1F30" stroke-width="1.5"/> </svg> </button> </h2> </div> <div id="collapseOne-264959208" class="collapse" aria-labelledby="headingOne" data-parent="#accordionExample-264959208"> <div class="card-body p-0"> <p><ul> <li><strong>GARDP created a screening strategy</strong>, implemented by Institut Pasteur Korea (IPK), for its work.</li> <li><strong>GARDP established an AMR Screening Consortium</strong> to screen compounds that had never been tested for antibiotic activity. As part of the consortium agreement, three Japanese pharmaceutical companies—Eisai, Takeda and Daiichi Sankyo—gave GARDP access to their libraries of proprietary chemical compounds. GARDP plans to screen libraries from two more companies soon.</li> <li><strong>GARDP screened the ReFRAME compound library from the non-profit research institute Calibr</strong> (part of Scripps Research, USA) for substances with the potential to restore activity to antibiotics increasingly affected by drug resistance. Current work is testing the activity of the promising compounds (“hits”) and synthesising new compounds (“analogues”) based on the structure of the hits identified by high-throughput screening.</li> <li><strong>GARDP partnered with Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)</strong> to screen a library of natural product extracts for antibiotic activity and to identify and characterise any active compounds.</li> <li><span class="TextRun SCXW244088013 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW244088013 BCX0"><strong>GARDP has partnered with Sumitomo Pharma</strong> to </span><span class="NormalTextRun SCXW244088013 BCX0">screen a set of compounds from its compound library.</span></span></li> <li><span class="TextRun SCXW244088013 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW244088013 BCX0"><strong><span class="TextRun SCXW134200751 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW134200751 BCX0">GARDP has partnered with </span></span><span class="TextRun SCXW134200751 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW134200751 BCX0" data-ccp-charstyle="normaltextrun" data-ccp-charstyle-defn="{"ObjectId":"a41cee61-bef0-4b6c-823c-a0e8c8949e6b|5","ClassId":1073872969,"Properties":[469775450,"normaltextrun",201340122,"1",134233614,"true",469778129,"normaltextrun",335572020,"1",469778324,"Default Paragraph Font"]}">Mitsubishi Tanabe Pharma Corporation </span></span></strong><span class="TextRun SCXW134200751 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW134200751 BCX0" data-ccp-charstyle="normaltextrun">to access over 50,000 compounds from MTPC’s compound library.</span></span><span class="EOP SCXW134200751 BCX0" data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span> </span></span><span class="EOP SCXW244088013 BCX0" data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></li> </ul> <p>As a next step in antibiotic discovery work, GARDP is now testing and optimizing promising compounds (“hits”). This work will make it possible to determine the viability of compounds for development into pre-clinical candidates (the basis for a new drug).</p> <p> </p> <ul> <li><strong>GARDP has signed a Master Service Agreement with TCG Life Sciences (TCGLS) in India</strong> to synthesise new analogues. Testing at TCGLS will also help identify those compounds that are non-toxic and drug-like (i.e. the chemical structures of the compounds have the features required by drugs).</li> </ul> </p> </div> </div> </div> </div> </div> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <div class="parallax-wrap-desktop d-none d-md-block"> <div data-rellax-zindex="5" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style="top: -8%; left: 87%; width: 200px; "> <img src="https://gardp.org/wp-content/uploads/2022/09/GroupGARDP-bacteria-white.svg" alt=""/> </div> <div data-rellax-zindex="10" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style="top: 80%; left: 50%; width: 550px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/GARDP-activity-against-drug-resistant-bacteria-e1665063144315.png.webp" alt=""/> </div> <div data-rellax-zindex="15" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style="top: 100px; left: 50%; width: 200px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/623c661768a61ea4e071970c_GARDP-vector_garphic-bacteria1-white.png.webp" alt=""/> </div> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: -257px; left: 50; width: 0px; z-index: 5;"> <img src="https://gardp.org/wp-content/uploads/2022/09/GroupGARDP-bacteria-white.svg" alt=""/> </div> <div data-rellax-zindex="10" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: -58px; left: -56; width: 550px; z-index: 10;"> <img src="https://gardp.org/wp-content/uploads/2022/10/GARDP-activity-against-drug-resistant-bacteria-e1665063144315.png.webp" alt=""/> </div> <div data-rellax-zindex="15" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style=" top: -202px; left: 50; width: 200px; z-index: 15;"> <img src="https://gardp.org/wp-content/uploads/2022/10/623c661768a61ea4e071970c_GARDP-vector_garphic-bacteria1-white.png.webp" alt=""/> </div> </div> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #ffffff" id=""> <div class="container"> <div class="row flex-row-reverse"> <div class="col-lg-6"> <h1 class="title mb-50 color-b h2">Horizon scanning reports and other exploratory activities for antibiotic research and development</h1> <div class="text-box"> <p><span style="font-weight: 400;">GARDP carries out studies and activities to further antibiotic discovery, research and development. In “</span><a href="https://gardp.org/publications/horizon-scanning-for-antibacterial-drug-discovery-projects-focused-on-who-critical-priority-gram-negative-bacterial-pathogens/" rel="noopener"><span style="font-weight: 400;">Horizon scanning for antibacterial drug discovery projects focused on WHO critical priority Gram-negative bacterial pathogens</span></a><span style="font-weight: 400;">”</span><span style="font-weight: 400;"> (2021), GARDP found that although the early discovery antibacterial pipeline is scientifically diverse, it is insufficient to deliver the necessary antibiotic treatments for infections caused by Gram-negative bacteria in the future. GARDP also has a project to identify unexploited bacterial targets with potential for antibiotic drug discovery programmes that focus on Gram-negative bacteria (especially </span><i><span style="font-weight: 400;">Klebsiella pneumoniae </span></i><span style="font-weight: 400;">and </span><i><span style="font-weight: 400;">Acinetobacter baumannii</span></i><span style="font-weight: 400;">) and direct-acting small molecules. </span><span style="font-weight: 400;">In addition, GARDP has reviewed pre-clinical studies of efflux inhibitors (that facilitate drug penetration into bacteria). The combination of these new chemical entities with antibiotics have great potential to overcome antibiotic resistance.</span></p> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <div class="parallax-wrap-desktop d-none d-md-block"> <div data-rellax-zindex="5" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style="top: 100%; left: -27%; width: 241px; "> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-bacteria@2x.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="0" style="top: 62px; left: -18%; width: 509px; "> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-antibiotics-keyvisual6-CMJN.png.webp" alt=""/> </div> <div data-rellax-zindex="15" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style="top: 100%; left: 8%; width: 199px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/GARDP-global-research-development.bacteria.png.webp" alt=""/> </div> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: -141px; left: 50; width: 241px; z-index: 5;"> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-bacteria@2x.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="0" style=" top: -106px; left: 50; width: 509px; z-index: 10;"> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-antibiotics-keyvisual6-CMJN.png.webp" alt=""/> </div> <div data-rellax-zindex="15" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: -93px; left: 50; width: 199px; z-index: 15;"> <img src="https://gardp.org/wp-content/uploads/2022/10/GARDP-global-research-development.bacteria.png.webp" alt=""/> </div> </div> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #00a1ad" id=""> <div class="container"> <div class="row"> <div class="col-lg-6"> <h1 class="title mb-50 color-a h2">Revamping an antibiotic database for 21st-century research </h1> <div class="text-box"> <p><span class="white"><b>GARDP, in partnership with the University of Leeds and the University of Edinburgh, is updating </b><a href="https://gardp.us20.list-manage.com/track/click?u=64e424b26aa0c39bd75769e8d&id=47ac5900ff&e=e84c1bb45e" target="_blank" rel="noopener"><b>AntibioticDB</b></a><span style="font-weight: 400;">. This searchable online database contains key information about antibiotics at all stages of development and post-approval, such as the target pathogens (spectrum of activity) and the highest development stage, as well as links to original articles and the </span><a href="https://gardp.us20.list-manage.com/track/click?u=64e424b26aa0c39bd75769e8d&id=a1823d603d&e=e84c1bb45e" target="_blank" rel="noopener"><span style="font-weight: 400;">IUPHAR/BPS Guide to Pharmacology</span></a><span style="font-weight: 400;">. The database contributes to antibiotic development by making it easy to locate antibiotics at all stages of development, as well as those approved for use in people. The database also includes undeveloped compounds, and in some cases, the reason for lack of development (e.g., toxicity, funding gaps or changes in business strategy). </span></span></p> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <div class="parallax-wrap-desktop d-none d-md-block"> <div data-rellax-zindex="5" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style="top: 50%; left: 50%; width: 730px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/bacteria-gardp-research-antibiotics.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="2" style="top: 100%; left: 50%; width: 249px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/623c661768a61ea4e071970c_GARDP-vector_garphic-bacteria1-white.png.webp" alt=""/> </div> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: -207px; left: 50; width: 730px; z-index: 5;"> <img src="https://gardp.org/wp-content/uploads/2022/10/bacteria-gardp-research-antibiotics.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="2" style=" top: -20px; left: 50; width: 182px; z-index: 10;"> <img src="https://gardp.org/wp-content/uploads/2022/10/623c661768a61ea4e071970c_GARDP-vector_garphic-bacteria1-white.png.webp" alt=""/> </div> </div> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #e4f2ff" id=""> <div class="container"> <div class="row flex-row-reverse"> <div class="col-lg-6"> <h1 class="title mb-50 color-b h2">Key milestones</h1> <div class="text-box"> <ul><li><span style="font-weight: 400;"><strong>SCREENED</strong> over 100,000 compounds plus microbial extracts for antibiotic activity</span></li><li><span style="font-weight: 400;"><strong>EVALUATED</strong> 10 chemical series (each corresponding to a “hit” compound) for antibiotic activity</span></li><li aria-level="7"><span style="font-weight: 400;"><strong>CURRENTLY TESTING</strong> chemical series (each corresponding to a “hit” compound) for potential for further drug development </span></li></ul><p><span class="metatext">Screening platform located in the Biosafety Level 2 laboratory of Institut Pasteur Korea (Credit: Institut Pasteur Korea)</span></p> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <img width="882" height="662" src="https://gardp.org/wp-content/uploads/2022/10/CellExplorer_BLS2-e1667866482949.png.webp" class="image-content m-0 glow-white" alt="Cellexplorer Bls2" decoding="async" srcset="https://gardp.org/wp-content/uploads/2022/10/CellExplorer_BLS2-e1667866482949.png.webp 882w, https://gardp.org/wp-content/uploads/2022/10/CellExplorer_BLS2-e1667866482949-500x375.png.webp 500w" sizes="(max-width: 882px) 100vw, 882px"/> <div class="parallax-wrap-desktop d-none d-md-block"> <div data-rellax-zindex="5" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style="top: 86px; left: 6%; width: 282px; "> <img src="https://gardp.org/wp-content/uploads/2022/09/GroupGARDP-bacteria-white.png" alt=""/> </div> <div data-rellax-zindex="10" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style="top: 100%; left: 44%; width: 145px; "> <img src="https://gardp.org/wp-content/uploads/2022/09/gardp-bacteria.png.webp" alt=""/> </div> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style=" top: 86px; left: 6%; width: 282px; z-index: 5;"> <img src="https://gardp.org/wp-content/uploads/2022/09/GroupGARDP-bacteria-white.png" alt=""/> </div> <div data-rellax-zindex="10" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style=" top: 100%; left: 44%; width: 145px; z-index: 10;"> <img src="https://gardp.org/wp-content/uploads/2022/09/gardp-bacteria.png.webp" alt=""/> </div> </div> </div> </div> </div> </div> </section> <section class="plain-text" style="background: linear-gradient(0deg, rgba(0,0,0,0.4), rgba(0,0,0,0.4)), url(https://gardp.org/wp-content/uploads/2023/02/AdobeStock_67739280.jpeg.webp) no-repeat center ; background-size: cover;" id=""> <div class="container"> <div class="row d-none d-md-flex"> <div class="col-6 col-md-6 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white h2">About discovery and exploratory research</h1> </div> </div> <div class="col-6 col-md-6 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white default"> </h1> </div> </div> </div> <div class="row"> <div class="col-12 col-md-6 parallax-wrap"> <div class="title d-flex d-md-none"> <div class="col-12 col-md-6 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white h2">About discovery and exploratory research</h1> </div> </div> </div> <div class="offset-md-1"> <div class="text-subtitle"> <p><span class="white"><span style="font-weight: 400;">In 1928, Alexander Fleming discovered antibiotics by chance when a mould got into an uncovered plate of </span><i><span style="font-weight: 400;">Staphylococcus </span></i><span style="font-weight: 400;">bacteria. That discovery revolutionized modern medicine and led to </span><span style="font-weight: 400;">the </span><span style="font-weight: 400;">“golden age” of antibiotic discovery in the 1950s and 60s. </span></span></p><p> </p><p><span class="white" style="font-weight: 400;">But almost immediately after scientists discovered antibiotics, they realized that bacteria could become drug-resistant. </span></p><p> </p><p><span class="white"><span style="font-weight: 400;">The number of drug-resistant infections continues to rise inexorably while investment in new antibiotics has fallen (due to, for example, </span><a href="https://www.nature.com/articles/d41586-020-02884-3" target="_blank" rel="noopener"><span style="font-weight: 400;">inadequate financial incentives</span></a><span style="font-weight: 400;"> and greater difficulty discovering and designing new compounds in the decades following </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095086/" target="_blank" rel="noopener"><span style="font-weight: 400;">the “golden age” of antibiotic discovery</span></a><span style="font-weight: 400;">). </span></span></p> </div> </div> <div class="offset-md-1 btn-wrap mt-50-25"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> <div class="col-12 col-md-6 parallax-wrap"> <div class="title d-flex d-md-none"> <div class="col-12 col-md-6 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white default"> </h1> </div> </div> </div> <div class="offset-md-1"> <div class="text-subtitle"> <p><span class="white"><span style="font-weight: 400;">Moreover, the introduction of genuinely innovative antibiotics with new chemical structures (“classes”) has stagnated—no new class of antibiotics has been developed </span><a href="https://www.pewtrusts.org/en/research-and-analysis/reports/2016/05/a-scientific-roadmap-for-antibiotic-discovery" target="_blank" rel="noopener"><span style="font-weight: 400;">since the 1980s</span></a><span style="font-weight: 400;">. Since resistance to one antibiotic often translates into resistance to its entire class, new antibiotic classes are essential to counter drug resistance. </span></span></p><p> </p><p><span class="white"><span style="font-weight: 400;">Unfortunately, resistance is growing faster than new antibiotics are being developed. In 2021, the </span><span style="font-weight: 400;">World Health Organization</span><span style="font-weight: 400;"> reported </span><a href="https://www.who.int/news/item/15-04-2021-global-shortage-of-innovative-antibiotics-fuels-emergence-and-spread-of-drug-resistance" target="_blank" rel="noopener"><span style="font-weight: 400;">the world is still failing to develop the antibiotic treatments</span></a></span><span style="font-weight: 400;"><span class="white"> that are desperately needed for the most dangerous bacteria. Discovery and exploratory research for new compounds must target these bacteria to contribute to the development of the innovative antibiotics of the future. </span> </span></p> </div> </div> <div class="offset-md-1 btn-wrap mt-50-25"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </section> <section class="plain-text readmore-text" style="background-color: #e4f2ff" id=""> <div class="container"> <div class="row d-none d-md-flex"> <div class="col-6 col-md-9 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 color-b h2">Learn more</h1> </div> </div> </div> <div class="row"> <div class="col-12 col-md-9 parallax-wrap"> <div class="title d-flex d-md-none"> <div class="col-12 col-md-9 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 color-b h2">Learn more</h1> </div> </div> </div> <div class="offset-md-1"> <div class="text-subtitle"> <ul><li>GARDP scientific article: <a href="https://gardp.org/publications/high-throughput-screening-of-small-molecules-libraries-identified-antibacterials-against-clinically-relevant-multidrug-resistant-a-baumannii-and-k-pneumoniae/">High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant <em>A. baumannii</em> and </a><em>K. pneumoniae </em>(April 2024)</li><li><span class="TextRun Highlight SCXW158103711 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW158103711 BCX0" data-ccp-charstyle="eop" data-ccp-charstyle-defn="{"ObjectId":"4e0fbfd5-22fa-4412-a8f0-6624c06e6b0f|57","ClassId":1073872969,"Properties":[469775450,"eop",201340122,"1",134233614,"true",469778129,"eop",335572020,"1",469778324,"Default Paragraph Font"]}">Discovery & exploratory research at GARDP: </span><a href="https://gardp.org/wp-content/uploads/2024/03/Discovery-Exploratory-Research-at-GARDP-_Objectives-and-Progress-Feb-2024.pdf"><span class="NormalTextRun SCXW158103711 BCX0" data-ccp-charstyle="eop">Objectives</span><span class="NormalTextRun SCXW158103711 BCX0" data-ccp-charstyle="eop"> and progress</span></a></span><span class="EOP SCXW158103711 BCX0" data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> (February 2024)</span></li><li style="text-align: left;"><span style="font-weight: 400;">GARDP Report: </span><a href="https://gardp.org/news-resources/horizon-scanning-for-antibacterial-drug-discovery-projects-focused-on-who-critical-priority-gram-negative-bacterial-pathogens/"><span style="font-weight: 400;">Horizon scanning for antibacterial drug discovery projects focused on WHO critical priority Gram-negative bacterial pathogens</span></a><span style="font-weight: 400;"> (2021)</span></li></ul> </div> </div> <div class="offset-md-1 btn-wrap mt-50-25"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </section> <a id="waaw-logo" href="https://gardp.org/events/world-amr-awareness-week-2024/"><img src="https://gardp.org/wp-content/themes/gardp2/assets/img/png/waaw-stamp.png"/></a><a class="btn btn-color-c white hidden" id="take-action" href="https://gardp.org/donate/" target="_self">Donate</a></main> </div> <style>.fa{color:#fff!important}</style> <div class="modal fade" id="newsletter-modal" tabindex="-1" role="dialog" aria-labelledby="newsletter-modalLabel" aria-hidden="true"> <div class="modal-dialog modal-dialog-centered" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true">×</span> </button> </div> <div class="modal-body"> <div class='fluentform ff-default fluentform_wrapper_6 ffs_default_wrap'><form data-form_id="6" id="fluentform_6" class="frm-fluent-form fluent_form_6 ff-el-form-top ff_form_instance_6_1 ff-form-loading ffs_default" data-form_instance="ff_form_instance_6_1" method="POST"><fieldset style="border: none!important;margin: 0!important;padding: 0!important;background-color: transparent!important;box-shadow: none!important;outline: none!important; 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