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</div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Bisoprolol</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 37 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-37" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">37 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A8%D9%8A%D8%B3%D9%88%D8%A8%D8%B1%D9%88%D9%84%D9%88%D9%84" title="بيسوبرولول – Arabic" lang="ar" hreflang="ar" data-title="بيسوبرولول" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%A8%DB%8C%D8%B2%D9%88%D9%BE%D8%B1%D9%88%D9%84%D9%88%D9%84" title="بیزوپرولول – South Azerbaijani" lang="azb" hreflang="azb" data-title="بیزوپرولول" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Bosnian" lang="bs" hreflang="bs" data-title="Bisoprolol" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Catalan" lang="ca" hreflang="ca" data-title="Bisoprolol" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Welsh" lang="cy" hreflang="cy" data-title="Bisoprolol" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – German" lang="de" hreflang="de" data-title="Bisoprolol" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%92%CE%B9%CF%83%CE%BF%CF%80%CF%81%CE%BF%CE%BB%CF%8C%CE%BB%CE%B7" title="Βισοπρολόλη – Greek" lang="el" hreflang="el" data-title="Βισοπρολόλη" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Spanish" lang="es" hreflang="es" data-title="Bisoprolol" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Basque" lang="eu" hreflang="eu" data-title="Bisoprolol" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A8%DB%8C%D8%B2%D9%88%D9%BE%D8%B1%D9%88%D9%84%D9%88%D9%84" title="بیزوپرولول – Persian" lang="fa" hreflang="fa" data-title="بیزوپرولول" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – French" lang="fr" hreflang="fr" data-title="Bisoprolol" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%B9%84%EC%86%8C%ED%94%84%EB%A1%A4%EB%A1%A4" title="비소프롤롤 – Korean" lang="ko" hreflang="ko" data-title="비소프롤롤" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%B2%D5%AB%D5%BD%D5%B8%D5%BA%D6%80%D5%B8%D5%AC%D5%B8%D5%AC" title="Բիսոպրոլոլ – Armenian" lang="hy" hreflang="hy" data-title="Բիսոպրոլոլ" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Croatian" lang="hr" hreflang="hr" data-title="Bisoprolol" data-language-autonym="Hrvatski" data-language-local-name="Croatian" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Indonesian" lang="id" hreflang="id" data-title="Bisoprolol" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Bisoprololo" title="Bisoprololo – Italian" lang="it" hreflang="it" data-title="Bisoprololo" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%91%D7%99%D7%A1%D7%95%D7%A4%D7%A8%D7%95%D7%9C%D7%95%D7%9C" title="ביסופרולול – Hebrew" lang="he" hreflang="he" data-title="ביסופרולול" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-ks mw-list-item"><a href="https://ks.wikipedia.org/wiki/%D8%A8%D8%B3%D9%88%D9%BE%D8%B1%D9%88%D9%84%D9%88%D9%84" title="بسوپرولول – Kashmiri" lang="ks" hreflang="ks" data-title="بسوپرولول" data-language-autonym="कॉशुर / کٲشُر" data-language-local-name="Kashmiri" class="interlanguage-link-target"><span>कॉशुर / کٲشُر</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Bisoprololum" title="Bisoprololum – Latin" lang="la" hreflang="la" data-title="Bisoprololum" data-language-autonym="Latina" data-language-local-name="Latin" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Bizoprolol" title="Bizoprolol – Hungarian" lang="hu" hreflang="hu" data-title="Bizoprolol" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%91%D0%B8%D1%81%D0%BE%D0%BF%D1%80%D0%BE%D0%BB%D0%BE%D0%BB" title="Бисопролол – Macedonian" lang="mk" hreflang="mk" data-title="Бисопролол" data-language-autonym="Македонски" data-language-local-name="Macedonian" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Dutch" lang="nl" hreflang="nl" data-title="Bisoprolol" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%93%E3%82%BD%E3%83%97%E3%83%AD%E3%83%AD%E3%83%BC%E3%83%AB" title="ビソプロロール – Japanese" lang="ja" hreflang="ja" data-title="ビソプロロール" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%AC%E0%AC%BE%E0%AC%87%E0%AC%B8%E0%AD%8B%E0%AC%AA%E0%AD%8D%E0%AC%B0%E0%AD%8B%E0%AC%B2%E0%AD%8B%E0%AC%B2" title="ବାଇସୋପ୍ରୋଲୋଲ – Odia" lang="or" hreflang="or" data-title="ବାଇସୋପ୍ରୋଲୋଲ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Polish" lang="pl" hreflang="pl" data-title="Bisoprolol" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Portuguese" lang="pt" hreflang="pt" data-title="Bisoprolol" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Romanian" lang="ro" hreflang="ro" data-title="Bisoprolol" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%91%D0%B8%D1%81%D0%BE%D0%BF%D1%80%D0%BE%D0%BB%D0%BE%D0%BB" title="Бисопролол – Russian" lang="ru" hreflang="ru" data-title="Бисопролол" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Simple English" lang="en-simple" hreflang="en-simple" data-title="Bisoprolol" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Slovenian" lang="sl" hreflang="sl" data-title="Bisoprolol" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Serbian" lang="sr" hreflang="sr" data-title="Bisoprolol" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Bisoprolol" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Bisoprololi" title="Bisoprololi – Finnish" lang="fi" hreflang="fi" data-title="Bisoprololi" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Turkish" lang="tr" hreflang="tr" data-title="Bisoprolol" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%91%D1%96%D1%81%D0%BE%D0%BF%D1%80%D0%BE%D0%BB%D0%BE%D0%BB" title="Бісопролол – Ukrainian" lang="uk" hreflang="uk" data-title="Бісопролол" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Bisoprolol" title="Bisoprolol – Vietnamese" lang="vi" hreflang="vi" data-title="Bisoprolol" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E6%AF%95%E7%B4%A2%E6%B4%9B%E5%B0%94" title="毕索洛尔 – Chinese" lang="zh" hreflang="zh" data-title="毕索洛尔" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q412515#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Bisoprolol" 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class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Beta-1 selective adrenenergic blocker medication used to treat cardiovascular diseases</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Bisoprolol">Bisoprolol</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span typeof="mw:File"><a href="/wiki/File:Bisoprolol.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/55/Bisoprolol.svg/240px-Bisoprolol.svg.png" decoding="async" width="240" height="132" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/55/Bisoprolol.svg/360px-Bisoprolol.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/55/Bisoprolol.svg/480px-Bisoprolol.svg.png 2x" data-file-width="924" data-file-height="508" /></a></span></td></tr><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span typeof="mw:File"><a href="/wiki/File:Bisoprolol_ball-and-stick.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a6/Bisoprolol_ball-and-stick.png/240px-Bisoprolol_ball-and-stick.png" decoding="async" width="240" height="134" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a6/Bisoprolol_ball-and-stick.png/360px-Bisoprolol_ball-and-stick.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a6/Bisoprolol_ball-and-stick.png/480px-Bisoprolol_ball-and-stick.png 2x" data-file-width="3273" data-file-height="1824" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Zebeta, Monocor, others</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/bisoprolol-fumarate.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a693024.html">a693024</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> C</li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">By mouth</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_C07" title="ATC code C07">C07AB07</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=C07AB07">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li> <li>In general: ℞ (Prescription only)</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">>90%</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">30%<sup id="cite_ref-Bühring_1986_4-0" class="reference"><a href="#cite_note-Bühring_1986-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data">50% <a href="/wiki/Liver" title="Liver">liver</a>, <a href="/wiki/CYP2D6" title="CYP2D6">CYP2D6</a>, <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">10–12 hours<sup id="cite_ref-Leopold_1986_5-0" class="reference"><a href="#cite_note-Leopold_1986-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data"><a href="/wiki/Kidney" title="Kidney">Kidney</a>, fecal (<2%)</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">(<i>RS</i>)-1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-<br />3-(isopropylamino)propan-2-ol</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=66722-44-9">66722-44-9</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/2405">2405</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7129">7129</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00612">DB00612</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.2312.html">2312</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/Y41JS2NL6U">Y41JS2NL6U</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D02342">D02342</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3127">CHEBI:3127</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL645">ChEMBL645</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022682">DTXSID6022682</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q412515#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.108.941">100.108.941</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q412515#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>18</sub><span title="Hydrogen">H</span><sub>31</sub><span title="Nitrogen">N</span><span title="Oxygen">O</span><sub>4</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002325449000000000♠"></span>325.449</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=O%28c1ccc%28cc1%29COCCOC%28C%29C%29CC%28O%29CNC%28C%29C">Interactive image</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chirality_(chemistry)" title="Chirality (chemistry)">Chirality</a></th><td class="infobox-data"><a href="/wiki/Racemic_mixture" title="Racemic mixture">Racemic mixture</a></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">O(c1ccc(cc1)COCCOC(C)C)CC(O)CNC(C)C</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:VHYCDWMUTMEGQY-UHFFFAOYSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=459980153&page2=Bisoprolol">(verify)</a></span></span></td></tr></tbody></table> <p><b>Bisoprolol</b>, sold under the brand name <b>Zebeta</b> among others, is a <a href="/wiki/Beta_blocker" title="Beta blocker">beta blocker</a> which is selective for the <a href="/wiki/Beta-1_receptor" class="mw-redirect" title="Beta-1 receptor">beta-1 receptor</a><sup id="cite_ref-AHFS2016_7-0" class="reference"><a href="#cite_note-AHFS2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> and used for <a href="/wiki/Cardiovascular_disease" title="Cardiovascular disease">cardiovascular diseases</a>,<sup id="cite_ref-AHFS2016_7-1" class="reference"><a href="#cite_note-AHFS2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> including <a href="/wiki/Tachyarrhythmias" class="mw-redirect" title="Tachyarrhythmias">tachyarrhythmias</a>, <a href="/wiki/High_blood_pressure" class="mw-redirect" title="High blood pressure">high blood pressure</a>, <a href="/wiki/Angina" title="Angina">angina</a>, and <a href="/wiki/Heart_failure" title="Heart failure">heart failure</a>.<sup id="cite_ref-AHFS2016_7-2" class="reference"><a href="#cite_note-AHFS2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> It is taken <a href="/wiki/Oral_administration" title="Oral administration">by mouth</a>.<sup id="cite_ref-AHFS2016_7-3" class="reference"><a href="#cite_note-AHFS2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Common side effects include <a href="/wiki/Headache" title="Headache">headache</a>, feeling tired, <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a>, and <a href="/wiki/Peripheral_edema" title="Peripheral edema">swelling in the legs</a>.<sup id="cite_ref-AHFS2016_7-4" class="reference"><a href="#cite_note-AHFS2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> More severe side effects include worsening <a href="/wiki/Asthma" title="Asthma">asthma</a>, blocking the ability to recognize <a href="/wiki/Low_blood_sugar" class="mw-redirect" title="Low blood sugar">low blood sugar</a>, and worsening <a href="/wiki/Heart_failure" title="Heart failure">heart failure</a>.<sup id="cite_ref-Pro2016_9-0" class="reference"><a href="#cite_note-Pro2016-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> There are concerns that use during <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a> may be harmful to the baby.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Bisoprolol was <a href="/wiki/Patent" title="Patent">patented</a> in 1976 and approved for medical use in 1986.<sup id="cite_ref-Fis2006_11-0" class="reference"><a href="#cite_note-Fis2006-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> It was approved for medical use in the United States in 1992.<sup id="cite_ref-AHFS2016_7-5" class="reference"><a href="#cite_note-AHFS2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Bisoprolol is on the <a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">World Health Organization's List of Essential Medicines</a><sup id="cite_ref-WHO23rd_12-0" class="reference"><a href="#cite_note-WHO23rd-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> and is available as a <a href="/wiki/Generic_medication" class="mw-redirect" title="Generic medication">generic medication</a>.<sup id="cite_ref-AHFS2016_7-6" class="reference"><a href="#cite_note-AHFS2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> In 2020, it was the 267th most commonly prescribed medication in the United States, with more than 1<span class="nowrap"> </span>million prescriptions.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:000859lg_Zebeta_5_MG_Oral_Tablet.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/000859lg_Zebeta_5_MG_Oral_Tablet.jpg/220px-000859lg_Zebeta_5_MG_Oral_Tablet.jpg" decoding="async" width="220" height="157" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/000859lg_Zebeta_5_MG_Oral_Tablet.jpg/330px-000859lg_Zebeta_5_MG_Oral_Tablet.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/000859lg_Zebeta_5_MG_Oral_Tablet.jpg/440px-000859lg_Zebeta_5_MG_Oral_Tablet.jpg 2x" data-file-width="840" data-file-height="600" /></a><figcaption>Zebeta 5-mg oral tablet</figcaption></figure> <p>Bisoprolol is used for prevention of cardiovascular events following a heart attack in patients with risk factors for disease progression,<sup id="cite_ref-Bangalore_2014_16-0" class="reference"><a href="#cite_note-Bangalore_2014-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> in the management of congestive heart failure with reduced ejection fraction,<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> and as a second-line agent for hypertension.<sup id="cite_ref-Wiysonge_2017_18-0" class="reference"><a href="#cite_note-Wiysonge_2017-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p><p>Bisoprolol may be beneficial in the treatment of high blood pressure, but it is not recommended as a first-line antihypertensive agent. It can be an adjunct to first-line antihypertensive agents in patients with accompanying comorbidities, for example, congestive heart failure, where selected beta blockers can be added in patients who remain mildly to moderately symptomatic despite appropriate doses of an angiotensin-converting-enzyme inhibitor.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p>In <a href="/wiki/Coronary_ischemia" title="Coronary ischemia">cardiac ischemia</a>, the drug is used to reduce the activity of the heart muscle, thereby reducing its oxygen and nutrient demands and allowing its reduced blood supply to still transport sufficient amounts of oxygen and nutrients to meet its needs.<sup id="cite_ref-PMID7923660_20-0" class="reference"><a href="#cite_note-PMID7923660-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PMID20354334_21-0" class="reference"><a href="#cite_note-PMID20354334-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PMID20354032_22-0" class="reference"><a href="#cite_note-PMID20354032-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Side_effects">Side effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=2" title="Edit section: Side effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>An overdose of bisoprolol can lead to fatigue, <a href="/wiki/Hypotension" title="Hypotension">hypotension</a>,<sup id="cite_ref-PMID20354334_21-1" class="reference"><a href="#cite_note-PMID20354334-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Hypoglycemia" title="Hypoglycemia">hypoglycemia</a>,<sup id="cite_ref-Leopold_1986c_23-0" class="reference"><a href="#cite_note-Leopold_1986c-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Leopold_1986b_24-0" class="reference"><a href="#cite_note-Leopold_1986b-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Bronchospasm" title="Bronchospasm">bronchospasms</a>, and <a href="/wiki/Bradycardia" title="Bradycardia">bradycardia</a>.<sup id="cite_ref-PMID20354334_21-2" class="reference"><a href="#cite_note-PMID20354334-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Bronchospasms and hypoglycemia occur because at high doses, the drug can be an antagonist for <a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β<sub>2</sub> adrenergic receptors</a> located in the lungs and liver. Bronchospasm occurs due to the blockage of β<sub>2</sub> receptors in the lungs. Hypoglycemia occurs due to decreased stimulation of <a href="/wiki/Glycogenolysis" title="Glycogenolysis">glycogenolysis</a> and <a href="/wiki/Gluconeogenesis" title="Gluconeogenesis">gluconeogenesis</a> in the liver via β<sub>2</sub> receptors.<sup id="cite_ref-PMID7923660_20-1" class="reference"><a href="#cite_note-PMID7923660-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PMID20354334_21-3" class="reference"><a href="#cite_note-PMID20354334-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hauck_1994_25-0" class="reference"><a href="#cite_note-Hauck_1994-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p><p>There have been no reported cases of clinically evident drug-induced liver injury associated with bisoprolol.<sup id="cite_ref-pmid31643790_26-0" class="reference"><a href="#cite_note-pmid31643790-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Cautions">Cautions</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=3" title="Edit section: Cautions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Non-selective beta-blockers should be avoided in people with asthma or bronchospasm as they may cause exacerbations and worsening of symptoms.<sup id="cite_ref-Morales_2014_27-0" class="reference"><a href="#cite_note-Morales_2014-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Morales_2017_28-0" class="reference"><a href="#cite_note-Morales_2017-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bennett_2021_29-0" class="reference"><a href="#cite_note-Bennett_2021-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> β<sub>1</sub> selective beta-blockers like bisoprolol have not been shown to cause an increase in asthma exacerbations,<sup id="cite_ref-Morales_2017_28-1" class="reference"><a href="#cite_note-Morales_2017-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> and may be cautiously tried in those with controlled, mild-to-moderate asthma with cardiac comorbidities. </p><p>A 2014 meta-analysis found that unlike non-selective beta-blockers, β<sub>1</sub> selective beta-blockers (bisoprolol) showed only a small impact on lung function, with patients remaining responsive to <a href="/wiki/Salbutamol" title="Salbutamol">salbutamol</a> (β<sub>2</sub> -agonist) rescue therapy and endorses the use of bisoprolol in select patients with controlled asthma.<sup id="cite_ref-Morales_2014_27-1" class="reference"><a href="#cite_note-Morales_2014-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> This was supported by a 2020 clinical trial where bisoprolol had no significant impact on bronchodilation post salbutamol administration.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=4" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Mechanism_of_action">Mechanism of action</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=5" title="Edit section: Mechanism of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Bisoprolol is cardioprotective because it selectively and competitively blocks <a href="/wiki/Catecholamine" title="Catecholamine">catecholamine</a> (<a href="/wiki/Adrenaline" title="Adrenaline">adrenaline</a>) stimulation of <a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub> adrenergic receptors</a> (adrenoreceptors), which are mainly found in the heart muscle cells and <a href="/wiki/Electrical_conduction_system_of_the_heart" class="mw-redirect" title="Electrical conduction system of the heart">heart conduction tissue</a> (cardiospecific), but also found in <a href="/wiki/Juxtaglomerular_cell" title="Juxtaglomerular cell">juxtaglomerular cells</a> in the kidney.<sup id="cite_ref-PMID7923660_20-2" class="reference"><a href="#cite_note-PMID7923660-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Normally, adrenaline and noradrenaline stimulation of the β<sub>1</sub> adrenoreceptor activates a <a href="/wiki/Signal_transduction" title="Signal transduction">signalling cascade</a> (<a href="/wiki/Gs_protein" class="mw-redirect" title="Gs protein">Gs protein</a> and <a href="/wiki/CAMP_receptor_protein" title="CAMP receptor protein">cAMP</a>) which ultimately leads to increased <a href="/wiki/Myocardial_contractility" title="Myocardial contractility">myocardial contractility</a> and increased heart rate of the heart muscle and <a href="/wiki/Cardiac_pacemaker" title="Cardiac pacemaker">heart pacemaker</a>, respectively.<sup id="cite_ref-PMID2564629_32-0" class="reference"><a href="#cite_note-PMID2564629-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> </p><p>Bisoprolol competitively blocks the activation of this cascade, so decreases the adrenergic tone/stimulation of the heart muscle and pacemaker cells. Decreased adrenergic tone shows less contractility of heart muscle and lowered heart rate of pacemakers.<sup id="cite_ref-Leopold_1986c_23-1" class="reference"><a href="#cite_note-Leopold_1986c-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Leopold_1986b_24-1" class="reference"><a href="#cite_note-Leopold_1986b-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Haeusler_1986_33-0" class="reference"><a href="#cite_note-Haeusler_1986-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="β1-selectivity"><span id=".CE.B21-selectivity"></span>β<sub>1</sub>-selectivity</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=6" title="Edit section: β1-selectivity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Bisoprolol β<sub>1</sub>-selectivity is especially important in comparison to other nonselective beta blockers. The effects of the drug are limited to areas containing β<sub>1</sub> adrenoreceptors, which is mainly the heart and part of the kidney.<sup id="cite_ref-Leopold_1986c_23-2" class="reference"><a href="#cite_note-Leopold_1986c-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Haeusler_1986_33-1" class="reference"><a href="#cite_note-Haeusler_1986-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> Bisoprolol, whilst β<sub>1</sub> adrenoceptor selective can help patients to avoid certain side-effects associated with non-selective beta-blocker activity<sup id="cite_ref-Leopold_1986_5-1" class="reference"><a href="#cite_note-Leopold_1986-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> at additional adrenoceptors (α<sub>1</sub> and β<sub>2</sub>), it does not signify its superiority in treating beta-blocker indicated cardiac conditions such as heart failure but could prove beneficial to patients with specific comorbidities.<sup id="cite_ref-Taniguchi_2013_34-0" class="reference"><a href="#cite_note-Taniguchi_2013-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Düngen_2011_35-0" class="reference"><a href="#cite_note-Düngen_2011-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> </p><p>Bisoprolol has a higher degree of β<sub>1</sub>-selectivity compared to <a href="/wiki/Atenolol" title="Atenolol">atenolol</a>, <a href="/wiki/Metoprolol" title="Metoprolol">metoprolol</a> and <a href="/wiki/Betaxolol" title="Betaxolol">betaxolol</a>.<sup id="cite_ref-pmid35093388_36-0" class="reference"><a href="#cite_note-pmid35093388-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> With a selectivity ranging from being 11 to 15 times more selective for β<sub>1</sub> over β<sub>2</sub>.<sup id="cite_ref-Haeusler_1986_33-2" class="reference"><a href="#cite_note-Haeusler_1986-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Harting_1986_37-0" class="reference"><a href="#cite_note-Harting_1986-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kaumann_1985_38-0" class="reference"><a href="#cite_note-Kaumann_1985-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Klockow_1986_39-0" class="reference"><a href="#cite_note-Klockow_1986-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Manalan_1981_40-0" class="reference"><a href="#cite_note-Manalan_1981-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Schliep_1986_41-0" class="reference"><a href="#cite_note-Schliep_1986-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Schliep_1984_42-0" class="reference"><a href="#cite_note-Schliep_1984-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Schnabel_2000_43-0" class="reference"><a href="#cite_note-Schnabel_2000-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Smith_1999_44-0" class="reference"><a href="#cite_note-Smith_1999-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Wellstein_1986_45-0" class="reference"><a href="#cite_note-Wellstein_1986-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> However, <a href="/wiki/Nebivolol" title="Nebivolol">nebivolol</a> is approximately 3.5 times more β<sub>1</sub>-selective.<sup id="cite_ref-Bundkirchen_2003_46-0" class="reference"><a href="#cite_note-Bundkirchen_2003-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Nuttall_2003_47-0" class="reference"><a href="#cite_note-Nuttall_2003-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Renin-angiotensin_system">Renin-angiotensin system</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=7" title="Edit section: Renin-angiotensin system"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Bisoprolol inhibits <a href="/wiki/Renin" title="Renin">renin</a> secretion by about 65% and <a href="/wiki/Tachycardia" title="Tachycardia">tachycardia</a> by about 30%.<sup id="cite_ref-Harting_1986_37-1" class="reference"><a href="#cite_note-Harting_1986-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=8" title="Edit section: Pharmacokinetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>After ingestion, bisoprolol is absorbed and has a high <a href="/wiki/Bioavailability" title="Bioavailability">bioavailability</a> of approximately 90% with plasma half-life of 10–12 hours.<sup id="cite_ref-Leopold_1986c_23-3" class="reference"><a href="#cite_note-Leopold_1986c-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Leopold_1986b_24-2" class="reference"><a href="#cite_note-Leopold_1986b-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> Typically, half the circulating bisoprolol is <a href="/wiki/Biotransformation" title="Biotransformation">metabolized</a> by the liver, the rest passing unchanged through the kidneys before elimination; less than 2% may be <a href="/wiki/Excretion" title="Excretion">excreted</a> in the <a href="/wiki/Feces" title="Feces">feces</a>.<sup id="cite_ref-Leopold_1986c_23-4" class="reference"><a href="#cite_note-Leopold_1986c-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Leopold_1986b_24-3" class="reference"><a href="#cite_note-Leopold_1986b-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Haeusler_1986_33-3" class="reference"><a href="#cite_note-Haeusler_1986-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p><p>Bisoprolol soluble in both lipids and water.<sup id="cite_ref-Leopold_1986c_23-5" class="reference"><a href="#cite_note-Leopold_1986c-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Haeusler_1986_33-4" class="reference"><a href="#cite_note-Haeusler_1986-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> It is classified as a beta blocker with moderate <a href="/wiki/Lipophilicity" title="Lipophilicity">lipophilicity</a> and hence intermediate potential for crossing the <a href="/wiki/Blood%E2%80%93brain_barrier" title="Blood–brain barrier">blood–brain barrier</a>.<sup id="cite_ref-pmid33572109_48-0" class="reference"><a href="#cite_note-pmid33572109-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> This in turn may result in fewer effects in the <a href="/wiki/Central_nervous_system" title="Central nervous system">central nervous system</a> as well as a lower risk of <a href="/wiki/Neuropsychiatric" class="mw-redirect" title="Neuropsychiatric">neuropsychiatric</a> side effects than highly lipophilic beta blockers like <a href="/wiki/Propranolol" title="Propranolol">propranolol</a> but greater such effects than beta blockers with low lipophilicity like <a href="/wiki/Atenolol" title="Atenolol">atenolol</a>.<sup id="cite_ref-pmid33572109_48-1" class="reference"><a href="#cite_note-pmid33572109-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </p><p>The plasma protein binding of bisoprolol is approximately 35%, the volume of distribution is 3.5 L/kg and the total clearance is approximately 15 L/h. Bisoprolol is eliminated from the body in two ways - 50% of the substance is converted in the liver to inactive metabolites, which are then excreted in the kidneys. The remaining 50% is eliminated unchanged via the kidneys.<sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> Since elimination is equal in liver and kidney, no dose adjustment is required in patients with hepatic or renal impairment. </p><p>The pharmacokinetics of bisoprolol are linear and independent of age.<sup id="cite_ref-Leopold_1986_5-2" class="reference"><a href="#cite_note-Leopold_1986-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>In patients with chronic heart failure, the plasma level of bisoprolol is higher and the half-life is longer than in healthy subjects when compared across studies. There is a lack of evidence directly comparing bisoprolol pharmacokinetics between healthy subjects and chronic heart failure subjects.<sup id="cite_ref-50" class="reference"><a href="#cite_note-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-51" class="reference"><a href="#cite_note-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=9" title="Edit section: Society and culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Brand_names">Brand names</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=10" title="Edit section: Brand names"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In India, it is sold under the brand name Bisotab.<sup id="cite_ref-52" class="reference"><a href="#cite_note-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bisoprolol&action=edit&section=11" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a 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Retrieved <span class="nowrap">14 December</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=drugs.com&rft.atitle=Bisoprolol+-+FDA+prescribing+information%2C+side+effects+and+uses&rft_id=https%3A%2F%2Fwww.drugs.com%2Fpro%2Fbisoprolol.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABisoprolol" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/pregnancy/bisoprolol.html">"Bisoprolol (Zebeta) Use During Pregnancy"</a>. <i>drugs.com</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20161221004229/https://www.drugs.com/pregnancy/bisoprolol.html">Archived</a> from the original on 21 December 2016<span class="reference-accessdate">. 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blockers"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Beta_blockers" title="Special:EditPage/Template:Beta blockers"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Beta_blockers_(C07)" style="font-size:114%;margin:0 4em"><a href="/wiki/Beta_blocker" title="Beta blocker">Beta blockers</a> (<a href="/wiki/ATC_code_C07" title="ATC code C07">C07</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta_adrenergic_receptor" class="mw-redirect" title="Beta adrenergic receptor">β</a>, non-selective</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alprenolol" title="Alprenolol">Alprenolol</a></li> <li><a href="/wiki/Bopindolol" title="Bopindolol">Bopindolol</a></li> <li><a href="/wiki/Bupranolol" title="Bupranolol">Bupranolol</a></li> <li><a href="/wiki/Carteolol" title="Carteolol">Carteolol</a></li> <li><a href="/wiki/Cloranolol" title="Cloranolol">Cloranolol</a></li> <li><a href="/wiki/Mepindolol" title="Mepindolol">Mepindolol</a></li> <li><a href="/wiki/Nadolol" title="Nadolol">Nadolol</a></li> <li><a href="/wiki/Oxprenolol" title="Oxprenolol">Oxprenolol</a></li> <li><a href="/wiki/Penbutolol" title="Penbutolol">Penbutolol</a></li> <li><a href="/wiki/Pindolol" title="Pindolol">Pindolol</a>/<a href="/wiki/Iodopindolol" title="Iodopindolol">Iodopindolol</a></li> <li><a href="/wiki/Propranolol" title="Propranolol">Propranolol</a><sup>#</sup></li> <li><a href="/wiki/Sotalol" title="Sotalol">Sotalol</a></li> <li><a href="/wiki/Tertatolol" title="Tertatolol">Tertatolol</a></li> <li><a href="/wiki/Timolol" title="Timolol">Timolol</a><sup>#</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub></a>-selective</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acebutolol" title="Acebutolol">Acebutolol</a></li> <li><a href="/wiki/Atenolol" title="Atenolol">Atenolol</a></li> <li><a href="/wiki/Betaxolol" title="Betaxolol">Betaxolol</a></li> <li><a href="/wiki/Bevantolol" title="Bevantolol">Bevantolol</a></li> <li><a class="mw-selflink selflink">Bisoprolol</a><sup>#</sup></li> <li><a href="/wiki/Celiprolol" title="Celiprolol">Celiprolol</a></li> <li><a href="/wiki/Epanolol" title="Epanolol">Epanolol</a></li> <li><a href="/wiki/Esmolol" title="Esmolol">Esmolol</a></li> <li><a href="/wiki/Landiolol" title="Landiolol">Landiolol</a></li> <li><a href="/wiki/Metoprolol" title="Metoprolol">Metoprolol</a></li> <li><a href="/wiki/Nebivolol" title="Nebivolol">Nebivolol</a></li> <li><a href="/wiki/Practolol" title="Practolol">Practolol</a></li> <li><a href="/wiki/Talinolol" title="Talinolol">Talinolol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β<sub>2</sub></a>-selective</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Butaxamine" title="Butaxamine">Butaxamine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α<sub>1</sub></a>- + β-selective</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Arotinolol" title="Arotinolol">Arotinolol</a></li> <li><a href="/wiki/Carvedilol" title="Carvedilol">Carvedilol</a></li> <li><a href="/wiki/Labetalol" title="Labetalol">Labetalol</a></li></ul> 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