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class="m-you-health-topics-navigation-content__category-label">Condition Headquarters:</h5><nav class="c-navigation-bar m-you-health-topics-navigation-content__content-nav m-you-health-topics-navigation-content__nav"><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__content-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/mental-health-behavior/anxiety-depression/major-depression-mdd"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__content-label m-you-health-topics-navigation-content__nav-label">Your guide to managing depression</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__content-link m-you-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/eye-health/understanding-treating-thyroid-eye-disease"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__content-label 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href="https://www.sharecare.com/joint-health/psoriatic-arthritis/managing-slowing-progression-psa"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__content-label m-you-health-topics-navigation-content__nav-label">Managing and slowing the progression of psoriatic arthritis</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__content-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/mental-health-behavior/add-adhd/manage-child-adhd"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__content-label m-you-health-topics-navigation-content__nav-label">Back to school pediatric ADHD headquarters</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__content-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/diabetes/type-2-diabetes/taking-control-type2-diabetes"><span 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class="c-link__label m-you-health-topics-navigation-content__nav-label">View All</span></a></div><nav class="c-navigation-bar m-you-health-topics-navigation-content__topic-nav m-you-health-topics-navigation-content__nav"><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/alzheimers-disease"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Alzheimer's disease</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/mental-health-behavior"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Mental health</span></a><a class="c-link 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m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Breast cancer</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/multiple-sclerosis"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Multiple sclerosis</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/cancer"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Cancer</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/parkinsons-disease"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Parkinson's disease</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/covid19"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Coronavirus</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/skin-health/psoriasis"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Psoriasis</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/digestive-health/crohns-disease"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Crohn's disease</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/joint-health/rheumatoid-arthritis"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Rheumatoid arthritis</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/diet-nutrition"><span class="c-link__label c-navigation-tab__label 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href="https://www.sharecare.com/infections/hepatitis-c"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Hepatitis C</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/diabetes/type-2-diabetes"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Type 2 diabetes</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/inflammation"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Inflammation</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/vaccinations-immunizations"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Vaccinations and immunizations</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/cancer/lung-cancer"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Lung cancer</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/weight-management"><span class="c-link__label c-navigation-tab__label 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m-you-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/mens-health"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">Men's health</span></a><a class="c-link c-navigation-tab m-you-health-topics-navigation-content__topic-link m-you-health-topics-navigation-content__nav-link view-more-topics" href="javascript:void(0)"><span class="c-link__label c-navigation-tab__label m-you-health-topics-navigation-content__topic-label m-you-health-topics-navigation-content__nav-label">View more</span></a></nav></div></div></div></div></div><div class="c-accordion m-you-header-bar__nav-group m-you-header-bar__nav-link is-inline"><input type="checkbox" id="you-accordion_0.819772856280246" class="c-accordion__trigger m-you-header-bar__nav-trigger"/><label class="c-accordion__label m-you-header-bar__nav-label" for="you-accordion_0.819772856280246"><span 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class="c-navigation-bar m-you-full-health-topics-navigation-content__topic-nav m-you-full-health-topics-navigation-content__nav"><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/alzheimers-disease"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Alzheimer's disease</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/anemia"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Anemia</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/joint-health/arthritis"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Arthritis</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/lung-health/asthma"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Asthma</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/mental-health-behavior/autism"><span class="c-link__label c-navigation-tab__label 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m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">COPD</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/covid19"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Coronavirus</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/digestive-health/crohns-disease"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Crohn's disease</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/healthy-aging/dementia"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Dementia</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/diet-nutrition"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Diet and nutrition</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/digestive-health"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Digestive health</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/womens-health/endometriosis"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Endometriosis</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/skin-health/eczema"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Eczema</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/exercise-fitness"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Exercise and fitness</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/chronic-pain/fibromyalgia"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Fibromyalgia</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/heart-health/heart-attack"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Heart attack</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/heart-health"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Heart health</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link" href="https://www.sharecare.com/infections/hepatitis-c"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Hepatitis C</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/heart-health/hypertension"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Hypertension</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/inflammation"><span class="c-link__label c-navigation-tab__label m-you-full-health-topics-navigation-content__topic-label m-you-full-health-topics-navigation-content__nav-label">Inflammation</span></a><a class="c-link c-navigation-tab m-you-full-health-topics-navigation-content__topic-link m-you-full-health-topics-navigation-content__nav-link desktop" href="https://www.sharecare.com/sleep-disorders/insomnia"><span class="c-link__label 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class="article-title">What causes endometrial cancer?</h1> <h3 class="article-subtitle">What we do and don鈥檛 know about the causes of the most common form of uterine cancer.</h3> <div class="sharecare-esi"><div class="c-page-layer m-social-share social-share-ms"><div class="c-layer-container l-grid-wrapper l-fluid-grid-container c-page-layer__container m-social-share__container"><span class="m-social-share__logo--icon-wrap icon__social--facebook" data-url="https://www.sharecare.com/health/endometrial-cancer/article/endometrial-cancer-causes-risk-factors?compId=sc-fb-sm-00-up-04172015"><a class="c-link m-social-share__logo" data-href="javascript:void(0);"><span class="c-svg-icon c-svg-icon--facebook--social"></span></a></span><span class="m-social-share__logo--icon-wrap icon__social--twitter" data-url="https://www.sharecare.com/health/endometrial-cancer/article/endometrial-cancer-causes-risk-factors?compId=sc-tw-sm-00-up-04172015"><a class="c-link m-social-share__logo" data-href="javascript:void(0);"><span class="c-svg-icon c-svg-icon--twitter--social"></span></a></span><span class="m-social-share__logo--icon-wrap icon__social--email" data-url="https://www.sharecare.com/health/endometrial-cancer/article/endometrial-cancer-causes-risk-factors?compId=sc-em-sm-00-up-02172016"><a class="c-link m-social-share__logo" data-href="javascript:void(0);"><span class="c-svg-icon c-svg-icon--email"></span></a></span></div></div><script defer="" src="https://s.sharecare.com/component-library/v/10/4/social-sharing.min.js"></script></div> <div class="article-image-wrapper"> <img src="https://res-1.cloudinary.com/sharecare/image/upload/c_fill,f_auto,w_640/v1691431423/articles/endometrial-cancer-causes-risk-factors" alt="While the exact cause of endometrial cancer is not known, hormonal imbalances are known to play an important role in its development." class="" width="640" height="" srcset="https://res-1.cloudinary.com/sharecare/image/upload/c_fill,dpr_1,f_auto,w_640/v1691431423/articles/endometrial-cancer-causes-risk-factors 1x,https://res-1.cloudinary.com/sharecare/image/upload/c_fill,dpr_2,f_auto,w_640/v1691431423/articles/endometrial-cancer-causes-risk-factors 2x,https://res-1.cloudinary.com/sharecare/image/upload/c_fill,dpr_3,f_auto,w_640/v1691431423/articles/endometrial-cancer-causes-risk-factors 3x" > </div> <div class="article-content"> <div class="attribution"> <div class="attribution__byline"> Written by <a href="https://www.sharecare.com/editorial-bios/#jameson-kowalczyk" target="_new">Jameson Kowalczyk</a>. Medically reviewed in August 2023 by <a href="https://www.sharecare.com/editorial-bios/#joanne-perron" target="_new">Joanne Perron, MD.</a> </div> </div> <p>Endometrial cancer is a type of cancer that begins in the uterus. More specifically, it is a type of cancer that begins in the endometrium, the layer of tissue that forms the inner lining of the uterus.</p> <p>More than 66,000 people in the United States are diagnosed with a form of uterine cancer each year, and roughly 90 percent of those cases are endometrial cancer. This makes endometrial cancer the most common gynecologic cancer in the U.S.</p> <h2>What is endometrial cancer?</h2> <p>Like other forms of cancer, endometrial cancer begins with mutations to the DNA of normal cells. These mutations result in cells that divide and multiply uncontrollably, disrupting the normal function of organs, invading nearby tissues, and causing other problems. With endometrial cancers, these mutations occur in the cells that make up the endometrium.</p> <h3>What are the symptoms of endometrial cancer?</h3> <p>The most common symptom of endometrial cancer is abnormal or unexpected vaginal bleeding (especially after age 40 and/or after menopause). Lower abdominal pain, pelvic cramping, feeling a mass, and unexplained weight loss are other possible symptoms.</p> <p>Symptoms like these should always be evaluated by a healthcare provider as soon as possible.</p> <h2>Is endometrial cancer caused by hormonal changes?</h2> <p>While the exact cause of endometrial cancer is not known, hormonal imbalances are known to play an important role in its development—specifically, an imbalance between the female sex hormones estrogen and progesterone.</p> <p>Here is a simplified explanation:</p> <ul> <li><strong>Estrogen</strong> stimulates the growth of endometrial tissue inside the uterus (among many other functions of the female reproductive system).</li> <li><strong>Progesterone</strong> helps regulate estrogen levels. When there is too much estrogen without enough progesterone to balance it out, estrogen dominance can occur. This is also known as “unopposed estrogen.”</li> <li>The <strong>unopposed estrogen</strong> results in unregulated production of endometrial tissue. This is believed to create an environment where endometrial cancer is more likely to occur.</li> </ul> <div class="ad__wrapper ad__wrapper--tapNative"> <div id="adx_native_ad_111052"></div> <script type="text/javascript">(function() {var a="",b=["aid=111052"];for (var c=0;c<b.length;++c){a+=b[c]+"&";}a+="r="+Math.random()*1e16+"&url="+encodeURIComponent(window.location.href);var x="https://content.tapnative.com/tn/?"+a;var y=document.createElement("script");y.type="text/javascript";y.async=true;y.src=x;var z=document.getElementsByTagName("script")[0];z.parentNode.insertBefore(y, z);})();</script> </div> <p>Again, the exact cause of endometrial cancer is not known, and there are still unanswered questions about why it occurs in some people and not others.</p> <p>Estrogen dominance is also associated with breast cancer, uterine fibroids, endometriosis, polycystic ovarian syndrome (PCOS), and endometrial hyperplasia (a precancerous thickening of the endometrium).</p> <h2>What are the risk factors for endometrial cancer?</h2> <p>A risk factor is anything associated with an increased risk of developing cancer. Many of the risk factors associated with endometrial cancer are related to hormonal imbalances. Risk factors include:</p> <ul> <li><strong>Age.</strong> The majority of cases are diagnosed in women between the ages of 45 and 74. However, endometrial cancers (as well as less common types of uterine cancers) occur in people across many different age groups.</li> <li><strong>Age at menstruation and menopause.</strong> Beginning menstruation before the age of 12 and/or late-onset menopause (after age 55) increases the number of menstrual cycles in a person’s life. A higher number of menstrual cycles is associated with an increased risk of endometrial cancer.</li> <li><strong>Obesity.</strong> Being overweight or obese put a person at a higher risk of having endometrial cancer. Excess body fat increases the levels of estrogen in the body, which can stimulate the growth of endometrium.</li> <li><strong>Previous cancers and cancer treatments.</strong> Breast cancer, ovarian cancer, pelvic cancers that have been treated with radiation, and certain hormone therapies used to treat or prevent breast cancer are associated with an increased risk of endometrial cancer.</li> <li><strong>Medical history.</strong> Including a history of PCOS, type 2 diabetes, hypertension, infertility, and endometrial hyperplasia.</li> <li><strong>Family history.</strong> A family history of endometrial cancer, ovarian cancer, and/or colorectal cancer is a risk factor for endometrial cancer. This includes Lynch Syndrome, or <em>hereditary nonpolyposis colorectal cancer</em> (HNPCC), a genetic disorder that increases the risk of some types of cancers.</li> <li><strong>Estrogen therapy.</strong> These are medications that contain estrogen without progesterone, which are sometimes used to treat menopausal symptoms. Estrogen-only therapies should only be used when the person taking the medication does not have a uterus (for example, if they have undergone a hysterectomy).</li> <li><strong>Race.</strong> The risk of endometrial cancer varies by race and ethnicity. For example, the incidence of endometrial cancer is higher in Caucasian women, but Black women and Hispanic women are more likely to be diagnosed at younger ages and with more aggressive forms of cancer.</li> </ul> <p>While it is helpful to know the risk factors for endometrial cancer, your best source of information about your health will always be your healthcare provider.</p> </div> <div class="article__sources__wrapper"> <span class="article__sources__header"> Article sources <img src="/articles-microsite/static/images/negative-positive.svg" alt="open article sources" /> </span> <div class="article__sources is__hidden"> <p>MedlinePlus. Endometrial Cancer.<br /> American Cancer Society. Key Statistics for Endometrial Cancer.<br /> National Cancer Institute. Cancer Stat Facts: Uterine Cancer.<br /> Heba Mahdy, Murray J. Casey, and David Crotzer. Endometrial Cancer. StatPearls. September 26, 2022.<br /> National Cancer Institute. What Is Cancer?<br /> American Cancer Society. Signs and Symptoms of Endometrial Cancer.<br /> Johns Hopkins Health. Estrogen's Effects on the Female Body.<br /> U.S. Department of Veterans Affairs Whole Health Library. Estrogen Dominance.<br /> M. Montanino Oliva, R. Gambioli, G. Forte, et al. Unopposed estrogens: current and future perspectives. European Review for Medical and Pharmacological Sciences, 2022. Vol. 26, No. 8.<br /> American Cancer Society. Endometrial Cancer Risk Factors.<br /> Yale Medicine. Endometrial Hyperplasia.<br /> MacMillan Cancer Support. Causes and risk factors.<br /> National Cancer Institute. Risk Factors for Cancer.<br /> Betina Biagetti and Manel Puig-Domingo. Age-Related Hormones Changes and Its Impact on Health Status and Lifespan. Aging and Disease, 2023. Vol. 14, No. 3.<br /> National Cancer Institute. 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