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U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4m0qyriQwlOrhSvowK_l5-eRZOf-I.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf1jvzRPA.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf8jvzRPA.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf3jvzRPA.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf2jvzRPA.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf4jvw.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf1jvzRPA.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf8jvzRPA.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf3jvzRPA.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf2jvzRPA.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf4jvw.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZVcf6lvg.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZXMf6lvg.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZV8f6lvg.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZVsf6lvg.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZWMf6.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-cSZMZ-Y.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-eCZMZ-Y.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-cyZMZ-Y.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-ciZMZ-Y.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-fCZM.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZVcf6lvg.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZXMf6lvg.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZV8f6lvg.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZVsf6lvg.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZWMf6.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZVcf6lvg.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZXMf6lvg.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZV8f6lvg.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZVsf6lvg.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZWMf6.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } :root { --font-base: sans-serif; --font-headings: Merriweather; } body, #content, .entry-content, .post-content, .page-content, .post-excerpt, .entry-summary, .entry-excerpt, .widget-area, .widget, .sidebar, #sidebar, footer, .footer, #footer, .site-footer { font-family: sans-serif; } #site-title, .site-title, #site-title a, .site-title a, .entry-title, .entry-title a, h1, h2, h3, h4, h5, h6, .widget-title, .elementor-heading-title { font-family: "Merriweather"; font-weight: 700; } </style>  </head> <body class="home blog franklin-child-1-0-11"> <div id="page" class="hfeed site"> <a class="skip-link screen-reader-text" href="#primary">Skip to content</a> <header id="masthead" class="site-header" role="banner"> <div class="site-header-top"> <div class="inner"> <a href="https://www.ncbi.nlm.nih.gov" class="site-description" role="img" aria-label="News about NCBI resources and events"><div>News about NCBI resources and events</div></a> <form id="header-search" action="https://ncbiinsights.ncbi.nlm.nih.gov/"> <input type="search" class="search-field" name="s" value="" /> <button 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widget_block"><a href="https://www.ncbi.nlm.nih.gov/books/NBK1969/">NCBI News Archive 1994-2017</a></aside> </div> </div> <div id="primary" class="content-area"> <main id="main" class="site-main" role="main"> <article id="post-14200" class="post-14200 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-icn3d"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/21/explore-3d-molecular-structures-icn3d/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/icn3d_Blog-2-e1732053808458.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Explore 3D Molecular Structures with iCn3D" decoding="async" fetchpriority="high" data-attachment-id="14203" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/21/explore-3d-molecular-structures-icn3d/icn3d_blog-2/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/icn3d_Blog-2-e1732053808458.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="icn3d_Blog (2)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/icn3d_Blog-2-e1732053808458.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/icn3d_Blog-2-e1732053808458.png?fit=1024%2C535&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/21/explore-3d-molecular-structures-icn3d/" rel="bookmark">Explore 3D Molecular Structures with iCn3D</a></h1> </header> <div class="entry-content"> <p><span data-contrast="auto">Do you want to analyze three-dimensional structures and highlight important features like active site residues, point mutations, and binding partners? Check out </span><a href="https://www.ncbi.nlm.nih.gov/Structure/icn3d/icn3d.html?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=icn3d-20241121"><span data-contrast="none">NCBI’s “I see in 3D” (iCn3D)</span></a><span data-contrast="auto"> – a free, web-based tool that allows you to explore the structure of a biomolecule at an atomistic level.</span><span data-ccp-props="{}"> </span></p> <h5><b><span data-contrast="auto">Features & Benefits</span></b><span data-ccp-props="{}"> </span></h5> <ul> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Interactively view 3D structure and corresponding sequence data </span></li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Align a protein sequence with unknown structure to a sequence-similar 3D structure </span></li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Interactively view 3D alignments of similar structures </span></li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">View the interaction interfaces in a structure </span></li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Save your custom display as a short URL or PNG image </span></li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Share a link to your customized display of a structure </span></li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Incorporate iCn3D into your own pages </span></li> </ul> <p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/21/explore-3d-molecular-structures-icn3d/#more-14200" class="more-link">Continue reading <span class="screen-reader-text">“Explore 3D Molecular Structures with iCn3D”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/21/explore-3d-molecular-structures-icn3d/" rel="bookmark"><time class="entry-date published" datetime="2024-11-21T10:12:58-05:00">November 21, 2024</time><time class="updated" datetime="2024-11-21T10:30:41-05:00">November 21, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/icn3d/" rel="tag">iCn3D</a></li></ul> </div> </footer> </article> <article id="post-14190" class="post-14190 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-comparative-genomics-resource-cgr tag-eukaryote-genome-annotation-pipeline-egap tag-genbank"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/20/development-version-egapx/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/EGAPx_Release-e1731950009661.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Try Out a Development Version of NCBI’s Publicly Available Annotation Tool, EGAPx" decoding="async" data-attachment-id="14192" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/20/development-version-egapx/egapx_release/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/EGAPx_Release-e1731950009661.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="EGAPx_Release" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/EGAPx_Release-e1731950009661.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/EGAPx_Release-e1731950009661.png?fit=1024%2C535&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/20/development-version-egapx/" rel="bookmark">Try Out a Development Version of NCBI’s Publicly Available Annotation Tool, EGAPx</a></h1> </header> <div class="entry-content"> <h3><i><span data-contrast="none">Latest release now available</span></i><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></h3> <p><span data-contrast="auto">Are you generating genomes for vertebrates, arthropods, or plants, and looking for a way to generate high-quality genome annotation? NCBI is working on a public version of the <a href="https://www.ncbi.nlm.nih.gov/refseq/annotation_euk/process/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=egapx-development-20241120">NCBI Eukaryotic Genome Annotation Pipeline</a> (EGAPx), and the latest developmental release is now available for testing and feedback. </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/20/development-version-egapx/#more-14190" class="more-link">Continue reading <span class="screen-reader-text">“Try Out a Development Version of NCBI’s Publicly Available Annotation Tool, EGAPx”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/20/development-version-egapx/" rel="bookmark"><time class="entry-date published updated" datetime="2024-11-20T09:45:49-05:00">November 20, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/comparative-genomics-resource-cgr/" rel="tag">Comparative Genomics Resource (CGR)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/eukaryote-genome-annotation-pipeline-egap/" rel="tag">Eukaryote Genome Annotation Pipeline (EGAP)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genbank/" rel="tag">GenBank</a></li></ul> </div> </footer> </article> <article id="post-14180" class="post-14180 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-comparative-genomics-resource-cgr tag-foreign-contamination-screen-fcs-tool tag-genbank tag-mane tag-ncbi-datasets tag-taxonomy tag-prokaryotes tag-refseq"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/14/refseq-release-227/"><img width="1108" height="737" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/iStock-1789702766-e1731518454958.jpg?resize=1100%2C694&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="RefSeq Release 227 is Available!" decoding="async" data-attachment-id="14186" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/14/refseq-release-227/red-fronted-brown-lemurs/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/iStock-1789702766-e1731518454958.jpg?fit=1100%2C694&ssl=1" data-orig-size="1100,694" data-comments-opened="1" data-image-meta="{"aperture":"6.3","credit":"Getty Images","camera":"ILCE-6300","caption":"eulemur rufifrons in Ranomafana","created_timestamp":"1697263195","copyright":"","focal_length":"350","iso":"800","shutter_speed":"0.01","title":"Red-fronted brown lemurs","orientation":"0"}" data-image-title="Red-fronted brown lemurs" data-image-description="" data-image-caption="<p>eulemur rufifrons in Ranomafana</p> " data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/iStock-1789702766-e1731518454958.jpg?fit=300%2C189&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/iStock-1789702766-e1731518454958.jpg?fit=1024%2C646&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/14/refseq-release-227/" rel="bookmark">RefSeq Release 227 is Available!</a></h1> </header> <div class="entry-content"> <p>Check out RefSeq release 227, now available <a href="https://www.ncbi.nlm.nih.gov/refseq/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-227-20241114">online</a> and from the <a href="https://ftp.ncbi.nlm.nih.gov/refseq/release/">FTP</a> site. You can access RefSeq data through <a href="https://www.ncbi.nlm.nih.gov/datasets/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-227-20241113">NCBI Datasets</a>. The release is provided in several directories as a complete dataset and also as divided by logical groupings.</p> <h5>What’s included in this release?</h5> <p>As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing:</p> <ul> <li><span style="font-size: 17px;">497,549,107 records, including </span></li> <li><span style="font-size: 17px;">377,783,847 proteins</span></li> <li><span style="font-size: 17px;">66,987,567 RNAs</span></li> <li><span style="font-size: 17px;">Sequences from 159,324 organisms </span></li> </ul> <p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/14/refseq-release-227/#more-14180" class="more-link">Continue reading <span class="screen-reader-text">“RefSeq Release 227 is Available!”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/14/refseq-release-227/" rel="bookmark"><time class="entry-date published updated" datetime="2024-11-14T09:52:45-05:00">November 14, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/comparative-genomics-resource-cgr/" rel="tag">Comparative Genomics Resource (CGR)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/foreign-contamination-screen-fcs-tool/" rel="tag">Foreign Contamination Screen (FCS) Tool</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genbank/" rel="tag">GenBank</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/mane/" rel="tag">Matched Annotation from NCBI and EMBL-EBI (MANE)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/ncbi-datasets/" rel="tag">NCBI Datasets</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/taxonomy/" rel="tag">NCBI Taxonomy</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/prokaryotes/" rel="tag">Prokaryotes</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/refseq/" rel="tag">RefSeq</a></li></ul> </div> </footer> </article> <article id="post-14156" class="post-14156 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-clinvar"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/06/improving-functional-data-clinvar/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/ClinVar_Functional_Data-3-e1730908195975.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Update! Improving the Representation of Functional Data in ClinVar" decoding="async" loading="lazy" data-attachment-id="14161" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/06/improving-functional-data-clinvar/clinvar_functional_data-3/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/ClinVar_Functional_Data-3-e1730908195975.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="ClinVar_Functional_Data (3)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/ClinVar_Functional_Data-3-e1730908195975.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/11/ClinVar_Functional_Data-3-e1730908195975.png?fit=1024%2C535&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/06/improving-functional-data-clinvar/" rel="bookmark">Update! Improving the Representation of Functional Data in ClinVar</a></h1> </header> <div class="entry-content"> <h3><i><span data-contrast="auto">We want your feedback!</span></i><span data-ccp-props="{}"> </span></h3> <p><span data-contrast="auto">As </span><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/10/improving-representation-functional-data-clinvar/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-functional-data-20241106"><span data-contrast="none">previously announced</span></a><span data-contrast="auto">, NCBI is improving the way that functional data are submitted to </span><a href="https://www.ncbi.nlm.nih.gov/clinvar/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-functional-data-20241106"><span data-contrast="none">ClinVar</span></a><span data-contrast="auto"> and how they are represented in the XML format and on the website. We have started enhancing support for functional data and would like your feedback! </span><span data-ccp-props="{}"> </span></p> <h5><b><span data-contrast="auto">What’s new?</span></b><span data-ccp-props="{}"> </span></h5> <p><span data-contrast="auto">We have updated the GitHub repository with:</span><span data-ccp-props="{}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;"><a href="https://github.com/ncbi/clinvar/tree/master/functional_data/submission">Updated submission templates</a> </span></li> <li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;"><a href="https://github.com/ncbi/clinvar/tree/master/functional_data/xsd">Updated XSDs</a> and <a href="https://github.com/ncbi/clinvar/tree/master/functional_data/reporting">sample XML files</a> </span></li> </ul> <p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/06/improving-functional-data-clinvar/#more-14156" class="more-link">Continue reading <span class="screen-reader-text">“Update! Improving the Representation of Functional Data in ClinVar”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/11/06/improving-functional-data-clinvar/" rel="bookmark"><time class="entry-date published updated" datetime="2024-11-06T11:59:48-05:00">November 6, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/clinvar/" rel="tag">ClinVar</a></li></ul> </div> </footer> </article> <article id="post-14137" class="post-14137 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-comparative-genomics-resource-cgr tag-ncbi-datasets tag-refseq"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/30/ortholog-data-refseq-arthropods/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/NCBI_Orthologs_Arthropods-2-e1730296635594.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Expansion of Ortholog Data for RefSeq Arthropods" decoding="async" loading="lazy" data-attachment-id="14147" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/30/ortholog-data-refseq-arthropods/ncbi_orthologs_arthropods-2/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/NCBI_Orthologs_Arthropods-2-e1730296635594.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="NCBI_Orthologs_Arthropods (2)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/NCBI_Orthologs_Arthropods-2-e1730296635594.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/NCBI_Orthologs_Arthropods-2-e1730296635594.png?fit=1024%2C535&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/30/ortholog-data-refseq-arthropods/" rel="bookmark">Expansion of Ortholog Data for RefSeq Arthropods</a></h1> </header> <div class="entry-content"> <h3><i><span data-contrast="auto">250K+ new </span></i>Hymenoptera<i><span data-contrast="auto"> orthologs added</span></i><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></h3> <p><span data-contrast="none">NCBI is excited to announce the expansion of ortholog data for <a href="https://www.ncbi.nlm.nih.gov/refseq/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-ortholog-expansion-20241030">RefSeq</a> arthropods. This update </span><span data-contrast="none">expands the breadth of arthropod orthology information</span><span data-contrast="none">, offering new insights into evolutionary biology, gene function, and shared pathways. Whether you’re studying insect genetics, developmental biology, or comparative genomics, the expanded ortholog data opens up new possibilities for research. </span><span data-contrast="none">Check out our </span><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/05/21/ortholog-groups-2-million-insect-genes/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-ortholog-expansion-20241030"><span data-contrast="none">previous blog</span></a><span data-contrast="none"> to learn how to access the orthologs using <a href="https://www.ncbi.nlm.nih.gov/datasets/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-ortholog-expansion-20241030">NCBI Datasets</a>.</span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/30/ortholog-data-refseq-arthropods/#more-14137" class="more-link">Continue reading <span class="screen-reader-text">“Expansion of Ortholog Data for RefSeq Arthropods”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/30/ortholog-data-refseq-arthropods/" rel="bookmark"><time class="entry-date published" datetime="2024-10-30T10:37:52-04:00">October 30, 2024</time><time class="updated" datetime="2024-10-31T10:46:01-04:00">October 31, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/comparative-genomics-resource-cgr/" rel="tag">Comparative Genomics Resource (CGR)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/ncbi-datasets/" rel="tag">NCBI Datasets</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/refseq/" rel="tag">RefSeq</a></li></ul> </div> </footer> </article> <article id="post-14122" class="post-14122 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-genome-data-viewer tag-mane tag-nucleotide tag-protein"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/MANE_Release-1-e1729890803554.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="MANE v1.4 with MANE Select for Non-Coding Genes" decoding="async" loading="lazy" data-attachment-id="14126" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/mane_release-1/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/MANE_Release-1-e1729890803554.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="MANE_Release (1)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/MANE_Release-1-e1729890803554.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/MANE_Release-1-e1729890803554.png?fit=1024%2C535&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/" rel="bookmark">MANE v1.4 with MANE Select for Non-Coding Genes</a></h1> </header> <div class="entry-content"> <p><span data-contrast="auto">The next release (v1.4) of </span><a href="https://www.ncbi.nlm.nih.gov/refseq/MANE/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mane-1.4-20241028"><span data-contrast="none">Matched Annotation from NCBI and EMBL-EBI (MANE)</span></a><span data-contrast="auto"> is here! MANE is a </span><a href="https://www.nature.com/articles/s41586-022-04558-8"><span data-contrast="none">collaborative dataset</span></a><span data-contrast="auto"> produced jointly by NCBI and EMBL-EBI that provides a representative transcript (MANE Select) for human protein-coding genes, to be used as universal standards for variant reporting and browser display. A second transcript, MANE Plus Clinical, is provided for genes where MANE Select alone is not sufficient to report all known variants. The new MANE release adds another important component to this high-value dataset – non-coding genes, some of which are known to be </span><a href="https://pubmed.ncbi.nlm.nih.gov/37968332/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mane-1.4-20241028"><span data-contrast="none">associated with human disease.</span></a><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/#more-14122" class="more-link">Continue reading <span class="screen-reader-text">“MANE v1.4 with MANE Select for Non-Coding Genes”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/" rel="bookmark"><time class="entry-date published" datetime="2024-10-28T09:47:17-04:00">October 28, 2024</time><time class="updated" datetime="2024-11-04T14:06:59-05:00">November 4, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genome-data-viewer/" rel="tag">Genome Data Viewer (GDV)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/mane/" rel="tag">Matched Annotation from NCBI and EMBL-EBI (MANE)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/protein/" rel="tag">Protein</a></li></ul> </div> </footer> </article> <article id="post-14098" class="post-14098 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-genbank"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/24/genbank-release-263/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/GenBank_Release-16-e1729707056730.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="GenBank Release 263.0 Now Available!" decoding="async" loading="lazy" data-attachment-id="14117" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/24/genbank-release-263/genbank_release-16/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/GenBank_Release-16-e1729707056730.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="GenBank_Release (16)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/GenBank_Release-16-e1729707056730.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/GenBank_Release-16-e1729707056730.png?fit=1024%2C535&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/24/genbank-release-263/" rel="bookmark">GenBank Release 263.0 Now Available!</a></h1> </header> <div class="entry-content"> <p><a href="https://www.ncbi.nlm.nih.gov/genbank/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=genbank-263-20241024">GenBank</a> release 263.0 (10/19/2024) is now available on the <a href="https://ftp.ncbi.nlm.nih.gov/genbank/">NCBI FTP site</a>. This release has 36.50 trillion bases and 5.13 billion records.</p> <p><strong>The current release has: </strong></p> <ul> <li><span style="font-size: 17px;">251,998,350 traditional records containing 4,250,942,573,681 base pairs of sequence data</span></li> <li><span style="font-size: 17px;">3,745,772,758 WGS records containing 31,362,454,467,668 base pairs of sequence data</span></li> <li><span style="font-size: 17px;">948,733,596 bulk-oriented TSA records containing 812,661,461,811 base pairs of sequence data</span></li> <li><span style="font-size: 17px;">187,349,395 bulk-oriented TLS records containing 77,037,504,468 base pairs of sequence data </span></li> </ul> <h5> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/24/genbank-release-263/#more-14098" class="more-link">Continue reading <span class="screen-reader-text">“GenBank Release 263.0 Now Available!”</span> <span class="meta-nav">→</span></a></h5> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/24/genbank-release-263/" rel="bookmark"><time class="entry-date published updated" datetime="2024-10-24T09:07:53-04:00">October 24, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genbank/" rel="tag">GenBank</a></li></ul> </div> </footer> </article> <article id="post-14105" class="post-14105 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-biosample"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/23/changes-ncbis-biosample-database/"><img width="1108" height="600" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/BioSample_Blog-e1729621385257.png?resize=1100%2C550&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Upcoming Changes to NCBI’s BioSample Database" decoding="async" loading="lazy" data-attachment-id="14109" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/23/changes-ncbis-biosample-database/biosample_blog/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/BioSample_Blog-e1729621385257.png?fit=1100%2C550&ssl=1" data-orig-size="1100,550" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="BioSample_Blog" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/BioSample_Blog-e1729621385257.png?fit=300%2C150&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/BioSample_Blog-e1729621385257.png?fit=1024%2C512&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/23/changes-ncbis-biosample-database/" rel="bookmark">Upcoming Changes to NCBI’s BioSample Database</a></h1> </header> <div class="entry-content"> <h3><i><span data-contrast="auto">Improving Metadata Quality</span></i><span data-ccp-props="{}"> </span></h3> <p><span data-contrast="auto">Do you rely on high-quality metadata from NCBI’s <a href="https://www.ncbi.nlm.nih.gov/biosample/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=biosample-metadata-20241023">BioSample</a> database? BioSample is home to metadata associated with the biological source materials used to generate raw reads, sequences, and other data submitted to NCBI. We are improving our submission process to ensure we provide you with more complete and robust information.</span><span data-ccp-props="{}"> </span></p> <h5><b><span data-contrast="auto">Attention submitters!</span></b><span data-ccp-props="{}"> </span></h5> <p><span data-contrast="auto">To improve metadata quality, we are introducing new submission validation steps and providing improved help documentation.</span><span data-ccp-props="{}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/23/changes-ncbis-biosample-database/#more-14105" class="more-link">Continue reading <span class="screen-reader-text">“Upcoming Changes to NCBI’s BioSample Database”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/23/changes-ncbis-biosample-database/" rel="bookmark"><time class="entry-date published updated" datetime="2024-10-23T09:41:25-04:00">October 23, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/biosample/" rel="tag">BioSample</a></li></ul> </div> </footer> </article> <article id="post-14079" class="post-14079 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-bookshelf"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/22/ncbi-bookshelf-learning-tools/"><img width="1100" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?resize=1100%2C627&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Explore NLM’s NCBI Bookshelf With New Learning Tools at Your Fingertips" decoding="async" loading="lazy" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?w=1100&ssl=1 1100w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?resize=300%2C171&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?resize=1024%2C584&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?resize=150%2C86&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?resize=768%2C438&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?resize=270%2C154&ssl=1 270w" sizes="auto, (max-width: 1100px) 100vw, 1100px" data-attachment-id="14081" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/22/ncbi-bookshelf-learning-tools/bookshelf_blog-3/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?fit=1100%2C627&ssl=1" data-orig-size="1100,627" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Bookshelf_Blog (3)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?fit=300%2C171&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/Bookshelf_Blog-3.png?fit=1024%2C584&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/22/ncbi-bookshelf-learning-tools/" rel="bookmark">Explore NLM’s NCBI Bookshelf With New Learning Tools at Your Fingertips</a></h1> </header> <div class="entry-content"> <h3><i><span data-contrast="none">New tutorials, queries, and discovery guides now available</span></i><span data-ccp-props="{"201341983":0,"335557856":16777215,"335559739":0,"335559740":240}"> </span></h3> <p><span data-contrast="auto">NLM’s </span><a href="https://www.ncbi.nlm.nih.gov/books/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=bookshelf-new-20241022"><span data-contrast="none">NCBI Bookshelf</span></a><span data-contrast="none"> provides free access to more than 13,000 peer-reviewed books and documents in life science and health care using over a dozen formats including monographs, reviews, reference works, government publications, standards and guidelines, technical reports, and textbooks. </span><span data-contrast="none">In acknowledgement of </span><a href="https://www.openaccessweek.org/"><span data-contrast="none">Open Access Week</span></a><span data-contrast="none">, we are excited to introduce new learning tools to better access and discover subject- and format-based collections within Bookshelf.</span></p> <p><span data-contrast="none"> Bookshelf strives to advance open and equitable science and scholarship. To achieve this goal, Bookshelf collaborates with over 150 content providers, more than half of which are nontraditional publishers like government agencies and non-governmental organizations, to make their content publicly accessible. This diverse body of content is organized into user-relevant subcollections, such as “health disparities,” to better facilitate access and discovery. Over half of this content is also available for programmatic reuse through </span><a href="https://www.ncbi.nlm.nih.gov/books/about/openaccess?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=bookshelf-new-20241022"><span data-contrast="none">Bookshelf’s Open Access Subset</span></a><span data-contrast="auto">.</span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335557856":16777215,"335559740":240}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/22/ncbi-bookshelf-learning-tools/#more-14079" class="more-link">Continue reading <span class="screen-reader-text">“Explore NLM’s NCBI Bookshelf With New Learning Tools at Your Fingertips”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/22/ncbi-bookshelf-learning-tools/" rel="bookmark"><time class="entry-date published updated" datetime="2024-10-22T10:03:26-04:00">October 22, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/bookshelf/" rel="tag">NCBI Bookshelf</a></li></ul> </div> </footer> </article> <article id="post-14062" class="post-14062 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-pubmed-central-pmc"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/21/pubmed-central-updated-website/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/PMC_Website_Updates-e1729099367886.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="PubMed Central (PMC) Transitions to Updated Website" decoding="async" loading="lazy" data-attachment-id="14064" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/21/pubmed-central-updated-website/pmc_website_updates/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/PMC_Website_Updates-e1729099367886.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="PMC_Website_Updates" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/PMC_Website_Updates-e1729099367886.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/PMC_Website_Updates-e1729099367886.png?fit=1024%2C535&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/21/pubmed-central-updated-website/" rel="bookmark">PubMed Central (PMC) Transitions to Updated Website</a></h1> </header> <div class="entry-content"> <h3><b><i><span data-contrast="none">The next step in the modernization of PMC</span></i></b><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></h3> <p><span data-contrast="auto">As </span><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/03/14/preview-pmc-improvements/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=pmc-modernization-20241021"><span data-contrast="none">previously announced</span></a><span data-contrast="auto">, NLM’s NCBI transitioned to an updated </span><a href="https://pmc.ncbi.nlm.nih.gov/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=pmc-modernization-20241021"><span data-contrast="none">PubMed Central (PMC)</span></a><span data-contrast="auto"> website, representing the next step in ongoing efforts to modernize NLM’s products and services. </span><span data-contrast="none">As part of this update, the primary URL for the PMC website has changed from ncbi.nlm.nih.gov/pmc to </span><a href="https://pmc.ncbi.nlm.nih.gov/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=pmc-modernization-20241021"><span data-contrast="none">pmc.ncbi.nlm.nih.gov</span></a><span data-contrast="none">. In addition, you’ll notice a new </span><span data-contrast="auto">look, feel, and organization of PMC article pages and the PMC Journal List. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335557856":16777215,"335559740":240}"> </span></p> <p><span data-contrast="none">The </span><span data-contrast="none">updated website</span><span data-contrast="none"> runs on cloud services to ensure the website’s long-term sustainability and reliability. It also incorporates </span><a href="https://designsystem.digital.gov/"><span data-contrast="none">U.S. Web Design System (USWDS) </span></a><span data-contrast="none">components and design principles to improve PMC’s readability and accessibility, whether </span><span data-contrast="none">you are </span><span data-contrast="none">visiting on </span><span data-contrast="none">a </span><span data-contrast="none">desktop computer, mobile device, or accessing its content using assistive technology.</span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335557856":16777215,"335559740":240}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/21/pubmed-central-updated-website/#more-14062" class="more-link">Continue reading <span class="screen-reader-text">“PubMed Central (PMC) Transitions to Updated Website”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/21/pubmed-central-updated-website/" rel="bookmark"><time class="entry-date published updated" datetime="2024-10-21T10:18:29-04:00">October 21, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/pubmed-central-pmc/" rel="tag">PubMed Central (PMC)</a></li></ul> </div> </footer> </article> <nav class="navigation posts-navigation" aria-label="Posts"> <h2 class="screen-reader-text">Posts navigation</h2> <div class="nav-links"><div class="nav-previous"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/page/2/" >Older posts</a></div></div> </nav> </main> </div> </div> <footer> <section class="icon-section"> <div id="icon-section-header" class="icon-section_header" tabindex="0">Contact NCBI on</div> <div class="grid-container"> <div class="icon-section_container"> <a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter"><svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none"> <title>Twitter</title> <g id="State=Default"> <path id="path1009" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path> </g> </svg></a> <a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 300 300"> <title>Facebook</title> <path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z"> </path> </svg></a> <a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 300 300"> <title>LinkedIn</title> <path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z"> </path> </svg></a> <a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 300 300"> <defs> <style> .cls-11, .cls-12 { fill: #737373; 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