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Sharri Cyrus - Graduate School - University of British Columbia - Vancouver - Canada
<!DOCTYPE html> <!--[if IEMobile 7]><html class="no-js iem7 oldie" lang="en" dir="ltr" ><![endif]--> <!--[if (IE 7)&!(IEMobile)]><html class="no-js ie7 oldie" lang="en" dir="ltr" ><![endif]--> <!--[if (IE 8)&!(IEMobile)]><html class="no-js ie8 oldie" lang="en" dir="ltr" ><![endif]--> <!--[if (IE 9)&!(IEMobile)]><html class="no-js ie9" lang="en" dir="ltr" ><![endif]--> <!--[[if (gt IE 9)|(gt IEMobile 7)]><!--><html class="no-js" lang="en" dir="ltr" ><!--<![endif]--> <head> <!--[if IE]><![endif]--> <link rel="dns-prefetch" href="//ajax.aspnetcdn.com" /> <link rel="dns-prefetch" href="//www.google-analytics.com" /> <link rel="dns-prefetch" href="//stats.g.doubleclick.net" /> <meta charset="utf-8" /> <script type="text/javascript">dataLayer = [{"FacultyContentGroup":"Faculty of Medicine"}];</script> <meta name="description" content="Mutations in the Polycomb Repressive Complex 2 (PRC2) members, EZH2, EED and SUZ12, cause overgrowth and intellectual disability syndromes, with variable severity. However, approximately 2.4% of the general population harbours a rare missense or nonsense variant in one of these genes. Challenges can arise when attributing causality or determining if these rare variants may" /> <meta name="abstract" content="Mutations in the Polycomb Repressive Complex 2 (PRC2) members, EZH2, EED and SUZ12, cause overgrowth and intellectual disability syndromes, with variable severity. However, approximately 2.4% of the general population harbours a rare missense or nonsense variant in one of these genes. Challenges can arise when attributing causality or determining if these rare variants may have subtler effects on health. My research focuses on defining the syndromic and non-syndromic clinical consequences of rare PRC2 variants seen in individuals and developing in vivo functional assays using Drosophila that will interrogate these variants and the impacts they have on gene function." /> <meta name="keywords" content=", Dr. William Gibson, BC Children's Hospital Research Institute" /> <meta name="robots" content="follow, index" /> <link rel="image_src" href="https://www.grad.ubc.ca/sites/default/files/styles/square__220x220_/public/students/sharricyrus_headshots_4275.jpg?itok=Kn3DOHc_" /> <link rel="canonical" href="https://www.grad.ubc.ca/campus-community/meet-our-students/cyrus-sharri" /> <link rel="shortlink" href="https://www.grad.ubc.ca/node/22489" /> <meta property="fb:app_id" content="1033499786694032" /> <meta property="og:site_name" content="UBC Graduate and Postdoctoral Studies" /> <meta property="og:type" content="profile" /> <meta property="og:url" content="https://www.grad.ubc.ca/campus-community/meet-our-students/cyrus-sharri" /> <meta property="og:title" content="Sharri Cyrus: The polycomb repressive complex 2 related syndromes: Clinical phenotypes to functional studies in drosophila" /> <meta property="og:description" content="Mutations in the Polycomb Repressive Complex 2 (PRC2) members, EZH2, EED and SUZ12, cause overgrowth and intellectual disability syndromes, with variable severity. However, approximately 2.4% of the general population harbours a rare missense or nonsense variant in one of these genes. Challenges can arise when attributing causality or determining if these rare variants may have subtler effects on health. My research focuses on defining the syndromic and non-syndromic clinical consequences of rare PRC2 variants seen in individuals and developing in vivo functional assays using Drosophila that will interrogate these variants and the impacts they have on gene function." /> <meta property="og:see_also" content="https://www.grad.ubc.ca/prospective-students/meet-our-students" /> <meta property="og:image" content="https://www.grad.ubc.ca/sites/default/files/styles/social_media_1600x900/public/students/sharricyrus_headshots_4275.jpg?itok=XPygPpYH" /> <meta property="og:image:secure_url" content="https://www.grad.ubc.ca/sites/default/files/styles/social_media_1600x900/public/students/sharricyrus_headshots_4275.jpg?itok=XPygPpYH" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@UBCGradSchool" /> <meta name="twitter:creator" content="@UBCGradSchool" /> <meta name="twitter:site:id" content="103156632" /> <meta name="twitter:creator:id" content="103156632" /> <meta name="twitter:url" content="https://www.grad.ubc.ca/campus-community/meet-our-students/cyrus-sharri" /> <meta name="twitter:title" content="Sharri Cyrus: The polycomb repressive complex 2 related syndromes:" /> <meta name="twitter:description" content="Mutations in the Polycomb Repressive Complex 2 (PRC2) members, EZH2, EED and SUZ12, cause overgrowth and intellectual disability syndromes, with variable severity. However, approximately 2.4% of the" /> <meta name="twitter:image" content="https://www.grad.ubc.ca/sites/default/files/styles/social_media_1200x628/public/students/sharricyrus_headshots_4275.jpg?itok=YQTMqkGb" /> <meta property="profile:first_name" content="Sharri" /> <meta property="profile:last_name" content="Cyrus" /> <title>Sharri Cyrus - Graduate School - University of British Columbia - Vancouver - Canada</title> <meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"> <meta name="HandheldFriendly" content="True"> <meta name="MobileOptimized" content="320"> <meta name="viewport" content="width=device-width"> <meta http-equiv="cleartype" content="on"> <!--[if lte IE 7]> <link href="/sites/all/themes/clf/clf/7.0.4/css/font-awesome-ie7.css" rel="stylesheet"> <![endif]--> <link rel="shortcut icon" href="/sites/all/themes/clf/clf/7.0.4/img/favicon.ico"> <link rel="apple-touch-icon-precomposed" sizes="144x144" 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class="icon-bar"></span> </span> </button> <!-- End of UBC Unit Flyout Menu Button --> <div class="full-width-container"> <!-- UBC Unit Breadcrumbs --> <div class="expand row-fluid crumbs"> <div class="container"> <ul class="breadcrumb expand"><ul class="breadcrumb expand"><li class="breadcrumb-home"><a href="/">Graduate School</a></li><li class="breadcrumb-0"></li> 禄 <li class="breadcrumb-1"><a href="/campus-community" title="Student Life & Community">Campus & Community</a></li> 禄 <li class="breadcrumb-2"><a href="/campus-community/meet-our-students" class="active">Meet our Students</a></li> 禄 <li class="active">Sharri Cyrus</li></ul></ul> </div> </div> <!-- End of UBC Unit Breadcrumbs --> <!-- Content Area --> <div class="container"> <div id="main" class="expand row-fluid contentwrapper-node-22489"> <div id="content" class="column maincontent-node-22489" role="main"> <section class="span12"> <div class="container"> <h1 class="page-header">Sharri Cyrus</h1> </div> <section id="block-system-main" class="block block-system block-even"> <!-- -*- mode: html-helper; before-save-hook: nil -*- --> <div class="panel-display panel-four-three-adaptive clear-block" id="color-background"> <!-- 4x4 grid --> <div class="container"> <!-- 100% - 1 column --> <div class="panel-panel line"> <div class="panel-panel unit span12"> <div class="panel-pane pane-fieldable-panels-pane pane-fpid-315 pane-bundle-card-horizontal" > <div class="pane-content"> <div class="card horizontal card-with-icon light-red "> <article> <div class="card-header"> <div class="card-icon"> <i class="fa icon-info-sign icon-medium"></i></div> </div> <div class="card-text card-align-left"> <div class="card-text-content"> <h4>Archived Content</h4> <div class="field field-name-field-pane-teaser field-type-text-long field-label-hidden"> <p>This student profile has been archived and is no longer being updated.</p> </div> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="container"> <!-- 25/75% - 2 columns --> <div class="panel-panel line"> <div class="panel-panel unit span3"> <div class="inside"> <div class="panel-pane pane-views-panes pane-students-panel-pane-24" > <div class="pane-content"> <div class="view view-students view-id-students view-display-id-panel_pane_24 image-animation view-dom-id-7c33afca141ce085a3527caf2c2d6525"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <div class="views-field views-field-field-student-photo"> <div class="field-content breathe"><a href="https://www.grad.ubc.ca/sites/default/files/students/sharricyrus_headshots_4275.jpg" title="Cyrus, Sharri" class="colorbox" data-colorbox-gallery="gallery-node-22489-elrJDJjBiM0" data-cbox-img-attrs="{"title": "", "alt": ""}"><img src="https://www.grad.ubc.ca/sites/default/files/styles/square__220x220_/public/students/sharricyrus_headshots_4275.jpg?itok=Kn3DOHc_&c=3e19f1828bbc624b8c49c99154198422" alt="" title="" /></a></div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-fieldable-panels-pane pane-fpid-92 pane-bundle-fieldable-panels-pane" > <div class="pane-content"> <div class="fieldable-panels-pane"> <div class="field field-name-field-panel-pane-body field-type-text-long field-label-hidden"> 聽 </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-res-topic" > <div class="pane-content"> <div class="field field-name-field-student-res-topic field-type-text field-label-above"> <label>Research topic</label> The polycomb repressive complex 2 related syndromes: Clinical phenotypes to functional studies in drosophila </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-panels-mini pane-profile-facts" > <div class="pane-content"> <div class="panel-display panel-1col clearfix" id="mini-panel-profile_facts"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-entity-field pane-taxonomy-term-field-faculty-internal-reference" > <div class="pane-content"> <div class="field field-name-field-faculty-internal-reference field-type-entityreference field-label-above"> <label>Faculty</label> <a href="/prospective-students/faculties/faculty-medicine">Faculty of Medicine</a> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-program-noderef" > <div class="pane-content"> <div class="field field-name-field-student-program-noderef field-type-entityreference field-label-above"> <label>Program</label> <a href="/prospective-students/graduate-degree-programs/phd-medical-genetics">Doctor of Philosophy in Medical Genetics (PhD)</a> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-supervisor-ref" > <div class="pane-content"> <div class="field field-name-field-supervisor-ref field-type-entityreference field-label-above"> <label>Research supervisor(s)</label> <a href="/researcher/15123-gibson">William Gibson</a> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-taxonomy-vocabulary-23" > <div class="pane-content"> <div class="field field-name-taxonomy-vocabulary-23 field-type-entityreference field-label-above"> <label>Country</label> Barbados </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-award-ref" > <div class="pane-content"> <div class="field field-name-field-student-award-ref field-type-entityreference field-label-above"> <label>Selected Award(s)</label> <div class="field-items"> <div class="field-item even"><a href="/awards/international-tuition-award">International Tuition Award</a></div> <div class="field-item odd"><a href="/awards/presidents-academic-excellence-initiative-phd-award">President's Academic Excellence Initiative PhD Award</a></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-fieldable-panels-pane pane-fpid-92 pane-bundle-fieldable-panels-pane" > <div class="pane-content"> <div class="fieldable-panels-pane"> <div class="field field-name-field-panel-pane-body field-type-text-long field-label-hidden"> 聽 </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-fieldable-panels-pane pane-fpid-125 pane-bundle-pane-button" > <div class="pane-content"> <div class="cta"> <a class="btn btn-full btn-main-2-rev" href="https://www.grad.ubc.ca/campus-community/meet-our-students"> <span class="title">Other Stories</span> </a> </div> </div> </div> </div> </div> <div class="panel-panel unit span9"> <div class="inside"> <div class="panel-pane pane-sharing-buttons extra-left-padding" > <div class="pane-content"> <div class="shariff" data-services="["twitter","facebook","linkedin","mail"]" data-theme="white" data-orientation="horizontal" data-twitter-via="UBCGradSchool" data-mail-url="mailto:" data-lang="en"></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-study-reason extra-left-padding" > <h5 class="pane-title"> Why did you decide to pursue a graduate degree? </h5> <div class="pane-content"> <div class="field field-name-field-student-study-reason field-type-text-long field-label-hidden"> <p>During an elective at the Albert Cecil Graham Development Centre in Barbados, I met children and adults whose clinical features made me suspect they had genetic disorders. However, they were stuck without a proper diagnosis as there were no local genetic services or regional services in the English-Speaking Caribbean. I decided I wanted to build capacity for genetic and genomic services in the Caribbean, one of the goals being: to set up and direct a diagnostic laboratory in Barbados. Also, if I had to pick a time that sparked my interest in rare disease research, that elective would be my choice. I knew I needed exposure, experience, and a solid knowledge base, so I embarked on my graduate school journey.</p> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-why-bc extra-left-padding" > <h5 class="pane-title"> Why did you decide to study at UBC? </h5> <div class="pane-content"> <div class="field field-name-field-student-why-bc field-type-text-long field-label-hidden"> <p>I wanted to ensure, that I would be a highly competitive candidate for future pursuits after my PhD. UBC fulfilled this requirement as being a top university in the world, with a reputation of research excellence. Additionally, I wanted to study in a place that would offer a new experience; previously I had never been to BC. After a little research, I decided that Vancouver would make a great place study. Lastly, the weather. No harsh winters!</p> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-why-ubc-program extra-left-padding" > <h5 class="pane-title"> What is it specifically, that your program offers, that attracted you? </h5> <div class="pane-content"> <div class="field field-name-field-student-why-ubc-program field-type-text-long field-label-hidden"> <p>I specifically wanted a program that was focused on medical genetics, with a diverse selection of research areas/ topics. At the time, I was interested in multiple areas in the field, and I found that the medical genetics program had potential supervisors that would be able to cater to whatever area I would finally pursue.</p> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-award-life extra-left-padding" > <h5 class="pane-title"> What was the best surprise about UBC or life in Vancouver? </h5> <div class="pane-content"> <div class="field field-name-field-student-award-life field-type-text-long field-label-hidden"> <p>At UBC I was happy to the see the myriad of services dedicated to student wellbeing. For life in Vancouver, I was not expecting the number of green spaces. It's very easy to find a park/ trail where you can go for a walk.</p> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-recrutiment-quote blockquote red extra-left-padding" > <div class="pane-content"> <div class="field field-name-field-student-recrutiment-quote field-type-text-long field-label-hidden"> I wanted to ensure, that I would be a highly competitive candidate for future pursuits after my PhD. UBC fulfilled this requirement as being a top university in the world, with a reputation of research excellence. </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-fieldable-panels-pane pane-fpid-92 pane-bundle-fieldable-panels-pane" > <div class="pane-content"> <div class="fieldable-panels-pane"> <div class="field field-name-field-panel-pane-body field-type-text-long field-label-hidden"> 聽 </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-previous-prep extra-left-padding" > <h5 class="pane-title"> What aspects of your life or career before now have best prepared you for your UBC graduate program? </h5> <div class="pane-content"> <div class="field field-name-field-student-previous-prep field-type-text-long field-label-hidden"> <p>I have a prior master of science in medical genetics and a medical degree. Therefore I came into my program with a solid grasp of concepts and skills that made it easier to do well in my courses and to carry out my research.</p> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-fun extra-left-padding" > <h5 class="pane-title"> What do you like to do for fun or relaxation? </h5> <div class="pane-content"> <div class="field field-name-field-student-fun field-type-text-long field-label-hidden"> <p>I love to read! You will always find me with my kindle.</p> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-student-tips extra-left-padding" > <h5 class="pane-title"> What advice do you have for new graduate students? </h5> <div class="pane-content"> <div class="field field-name-field-student-tips field-type-text-long field-label-hidden"> <p>The experience that you have at UBC is pretty much in your hands. For your academic journey endeavor to build healthy working relationships with your supervisor and your lab mates, as this will set the stage for a great working environment. Additionally, make sure you have a good work-life balance. It is very easy to get caught up in experiments. There is something for everyone at UBC and by extension in Vancouver, and you can definitely find activities that you will enjoy.</p> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-fieldable-panels-pane pane-fpid-92 pane-bundle-fieldable-panels-pane" > <div class="pane-content"> <div class="fieldable-panels-pane"> <div class="field field-name-field-panel-pane-body field-type-text-long field-label-hidden"> 聽 </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-fieldable-panels-pane pane-fpid-126 extra-left-padding pane-bundle-pane-button" > <div class="pane-content"> <div class="cta"> <a class="btn btn-full btn-main-2-alt" href="https://www.grad.ubc.ca/campus-community/meet-our-students"> <span class="title">View More Student Stories</span> </a> </div> </div> </div> </div> </div> </div> </div> <div class="container"> <!-- 25/75% - 2 columns --> <div class="panel-panel line"> <div class="panel-panel unit span3"> <div class="inside"> <div class="panel-pane pane-fieldable-panels-pane pane-fpid-92 pane-bundle-fieldable-panels-pane" > <div class="pane-content"> <div class="fieldable-panels-pane"> <div class="field field-name-field-panel-pane-body field-type-text-long field-label-hidden"> 聽 </div> </div> </div> </div> </div> </div> <div class="panel-panel unit span9"> <div class="inside"> <div class="panel-pane pane-views-panes pane-students-panel-pane-25 extra-left-padding" > <div class="pane-content"> <div class="view view-students view-id-students view-display-id-panel_pane_25 image-animation view-dom-id-d40363409ca87662e1786631e1149147"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <div class="views-field views-field-field-student-photo"> <div class="field-content breathe"></div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-fieldable-panels-pane pane-fpid-92 pane-bundle-fieldable-panels-pane" > <div class="pane-content"> <div class="fieldable-panels-pane"> <div class="field field-name-field-panel-pane-body field-type-text-long field-label-hidden"> 聽 </div> </div> </div> </div> </div> </div> </div> </div> <!-- full width content --> <div class="panel-panel line inflate"> <div class="panel-panel unit span12"> <div class="panel-pane pane-panels-mini pane-profiles-research-description banner-sec" > <div class="pane-content"> <div class="panel-display panel-1col clearfix" id="mini-panel-profiles_research_description"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-entity-field pane-node-field-student-res-desc container" > <h4 class="pane-title"> Learn more about Sharri's research </h4> <div class="pane-content"> <div class="field field-name-field-student-res-desc field-type-text-long field-label-hidden"> <p>Mutations in the Polycomb Repressive Complex 2 (PRC2) members, EZH2, EED and SUZ12, cause overgrowth and intellectual disability syndromes, with variable severity. However, approximately 2.4% of the general population harbours a rare missense or nonsense variant in one of these genes. Challenges can arise when attributing causality or determining if these rare variants may have subtler effects on health. My research focuses on defining the syndromic and non-syndromic clinical consequences of rare PRC2 variants seen in individuals and developing in vivo functional assays using Drosophila that will interrogate these variants and the impacts they have on gene function.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <!-- 3x3 grid --> <!-- full width content --> <div class="panel-panel line inflate"> <div class="panel-panel unit span12"> <div class="rounded-shadow region-plain-box-banner-grey"> <div class="rounded-shadow-background"> <div class="rounded-shadow-wrap-corner"> <div class="rounded-shadow-top-edge"> <div class="rounded-shadow-left"></div> <div class="rounded-shadow-right"></div> </div> <div class="rounded-shadow-left-edge"> <div class="rounded-shadow-right-edge clearfix"> <div class="panel-pane pane-views-panes pane-cta-randomized-display-panel-pane-1 container last-item-padding-clear" > <div class="pane-content"> <div class="view 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