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class="search-toggle"><i class="icon-search"></i></a></li></ul></div></nav> <div style="padding-top:10px;text-align:center"><div id='jumbo-banner-ad-container' style='min-width: 970px; min-height: 90px;'></div></div> <div class="archive-intro"><div class="wrap"><h1 class="archive-title"><span>Smart factory technology</span></h1></div></div><div class="site-inner"><div class="wrap"><div class="content-sidebar-wrap"><main class="content"><article class="type-post entry has-post-thumbnail" aria-label="CellProthera inks deal for GMP cell therapy manufacturing"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">December 13, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/cellprothera-inks-deal-for-gmp-cell-therapy-manufacturing/">CellProthera inks deal for GMP cell therapy manufacturing</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/cellprothera-inks-deal-for-gmp-cell-therapy-manufacturing/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/12/CellProthera-Logo-1-268x170.png" class="alignleft post-image entry-image wp-image-16544" alt="CellProthera Logo (1)" decoding="async" /></a><p>CellProthera announced a deal with Shonan Kamakura General Hospital (SKGH) to transfer technology to enable cell therapy manufacturing for clinical trials. The memorandum of understanding allows for GMP manufacturing of CD34+ endothelial progenitor cells (EPCs) for autologous therapy clinical trials. Takayuki Asahara of SKGH intends to adopt CellProthera’s StemXpand platform for clinical trials starting next…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Eli Lilly to invest $3B in Wisconsin manufacturing plant expansion"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">December 6, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/eli-lilly-3b-wisconsin-plant-expansion/">Eli Lilly to invest $3B in Wisconsin manufacturing plant expansion</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/eli-lilly-3b-wisconsin-plant-expansion/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/12/Eli-Lilly-Kenosha-Wisconsin-expansion-rendering-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16536" alt="Eli Lilly Kenosha Wisconsin expansion rendering (1)" decoding="async" loading="lazy" /></a><p>Eli Lilly (NYSE:LLY) announced that it plans to invest $3 billion in the expansion of its manufacturing facility in Kenosha County, Wisconsin. In April, Indianapolis-based Eli Lilly acquired the plant in Pleasant Prairie, Wisconsin, from sterile manufacturer Nexus. The company expects its investment to extend its global parenteral (injectable) product manufacturing network. It aims to…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="GBI Biomanufacturing expands capabilities with automated aseptic fill-finish"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">November 20, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/gbi-expands-capabilities-automated-fill-finish/">GBI Biomanufacturing expands capabilities with automated aseptic fill-finish</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/gbi-expands-capabilities-automated-fill-finish/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/11/GBI-Biomanufacturing-Logo-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16509" alt="GBI Biomanufacturing Logo (1)" decoding="async" loading="lazy" /></a><p>GBI Biomanufacturing announced today that it expanded its drug product (DP) services to include automated sterile fill and finish capabilities. Plantation, Florida–based GBI says it can support clients from clinical trials to commercial launch, both for drug products and drug substances. All of this can take place at its Florida plant, delivering advanced and flexible…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="How biometric ID is boosting security and efficiency in pharma manufacturing"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/cnewmarker/" class="entry-author-link" rel="author"><span class="entry-author-name">Chris Newmarker</span></a></span> | <time class="entry-time">November 14, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/how-biometric-id-is-boosting-security-and-efficiency-in-pharma-manufacturing/">How biometric ID is boosting security and efficiency in pharma manufacturing</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/how-biometric-id-is-boosting-security-and-efficiency-in-pharma-manufacturing/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/11/ARISTA-Wearable-Identity-Authentication-268x170.jpg" class="alignleft post-image entry-image wp-image-16497" alt="This is an Arista Corp. marketing image showing pharmaceutical workers using Nymi Bands and their biometric ID." decoding="async" loading="lazy" /></a><p>A maker of pharma manufacturing workstations says wearable biometric ID products are solving a security and efficiency challenge. Traditionally, pharmaceutical manufacturers have used a complex patchwork of access points, workstations, and tools, according to Fremont, California–based Arista Corp. Think badges, passwords and more, with the potential for someone other than the intended operator to gain…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Cellular Origins, Fresenius Kabi partner to automate cell, gene therapy manufacturing"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">October 16, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/cellular-origins-fresenius-kabi-cell-therapy/">Cellular Origins, Fresenius Kabi partner to automate cell, gene therapy manufacturing</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/cellular-origins-fresenius-kabi-cell-therapy/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/10/Fresenius-Kabi-Cellular-Origins-development-agreement-268x170.jpg" class="alignleft post-image entry-image wp-image-16472" alt="Fresenius Kabi Cellular Origins development agreement" decoding="async" loading="lazy" /></a><p>Cellular Origins and Fresenius Kabi announced today that they signed a development agreement over cell and gene therapies (CGTs). The agreement leverages both companies’ expertise in CGTs. They aim to digitally and physically integrate Fresenius Kabi’s suite of cell therapy processing technologies with Cellular Origins’ CGT robotic manufacturing platform, Constellation. With this integration, the companies…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Nipro launches new glass vials powered by Stevanato Group’s EZ-fill tech"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">October 7, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/nipro-launches-new-glass-vials-stevanato/">Nipro launches new glass vials powered by Stevanato Group’s EZ-fill tech</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/nipro-launches-new-glass-vials-stevanato/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/10/Nipro-PharmaPackaging-D2F-glass-vials-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16466" alt="Nipro PharmaPackaging D2F glass vials (1)" decoding="async" loading="lazy" /></a><p>Nipro PharmaPackaging announced today that it launched new D2F (direct-to-fill) glass vials powered by Stevanato Group technology. The vials feature Stevanato’s EZ-fill technology to offer a high-quality, ready-to-use (RTU) solution. Nipro designed the vials to meet the rigorous standards and increasing requirements of the pharmaceutical industry. D2F vials are washed, depyrogenated, packaged in nest and…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="PCI Pharma Services makes $365M investment in drug delivery device manufacturing"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">September 25, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/pci-pharma-services-365m-investment-manufacturing/">PCI Pharma Services makes $365M investment in drug delivery device manufacturing</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/pci-pharma-services-365m-investment-manufacturing/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/09/Rockford-IL-Campus-Expansion-PCI-Pharma-Services-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16454" alt="Rockford, IL Campus Expansion - PCI Pharma Services (1)" decoding="async" loading="lazy" /></a><p>PCI Pharma Services announced that it’s investing more than $365 million in infrastructure to support assembly and packaging efforts. The investment supports the clinical- and commercial-scale final assembly and packaging of drug-device combination products utilizing advanced drug delivery systems, with an emphasis on injectable formats. PCI Pharma plans to put its investment toward new and…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Wheeler Bio licenses antibody production tech from ATUM"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/swhooley/" class="entry-author-link" rel="author"><span class="entry-author-name">Sean Whooley</span></a></span> | <time class="entry-time">September 24, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/wheeler-bio-licenses-antibody-production-atum/">Wheeler Bio licenses antibody production tech from ATUM</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/wheeler-bio-licenses-antibody-production-atum/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/09/Wheeler-Bio-Portable-CMC-platform-1-268x170.jpg" class="alignleft post-image entry-image wp-image-16449" alt="Wheeler Bio Portable CMC platform (1)" decoding="async" loading="lazy" /></a><p>Wheeler Bio announced today that it expanded its capabilities through the licensing of ATUM’s miFuc platform. ATUM designed miFuc for the expression of recombinant proteins containing afucosylated glycans. The technology supports the development of antibodies with a significant reduction in fucosylation without affecting product titer, cellular growth rates or incurring global glycan liabilities. ATUM’s proprietary…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Sanofi, Novartis among Time’s most sustainable companies"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/cnewmarker/" class="entry-author-link" rel="author"><span class="entry-author-name">Chris Newmarker</span></a></span> | <time class="entry-time">July 2, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/sanofi-novartis-among-times-most-sustainable-companies/">Sanofi, Novartis among Time’s most sustainable companies</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/sanofi-novartis-among-times-most-sustainable-companies/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/07/Sustainability-268x170.jpg" class="alignleft post-image entry-image wp-image-16382" alt="This Unsplash image of a tree on a mistly day is meant to represent sustainability which was the focus of the Time most sustainable companies report that Pharmaceutical Processing World is citing for most sustainable pharma companies." decoding="async" loading="lazy" /></a><p>Pharma giants Sanofi and Novartis came in at No. 7 and 17, respectively, in Time magazine’s “Most Sustainable Companies of 2024” rankings. Overall, nearly 40 of the 500 companies on the list fell under the category of Chemicals, Drugs & Biotechnology. Other large pharma companies making it into the top half of the 500 included…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="A guide to implementing operational excellence in drug development"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="" class="entry-author-link" rel="author"><span class="entry-author-name">Rich Tree</span></a></span> | <time class="entry-time">January 31, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/operational-excellence-pharma-rd/">A guide to implementing operational excellence in drug development</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/operational-excellence-pharma-rd/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/01/AdobeStock_512901854-268x170.jpeg" class="alignleft post-image entry-image wp-image-16224" alt="operational excellence" decoding="async" loading="lazy" /></a><p>When it comes to drug development and manufacturing, operational excellence (OpEx) is critical for success at all levels. It can help establish a culture of continuous improvement and innovation while supporting data quality, compliance, customer satisfaction, and more. It can even impact external perceptions of the company and confidence in the strength of the business.…</p> </div><footer class="entry-footer"></footer></article><div class="archive-pagination pagination"><div class="pagination-next alignright"><a href="https://www.pharmaceuticalprocessingworld.com/category/iot/page/2/" class="button">Next ></a></div></div></main><aside class="sidebar sidebar-primary widget-area" role="complementary" aria-label="Primary Sidebar"><section id="custom_html-11" class="widget_text widget widget_custom_html"><div class="widget_text widget-wrap"><div class="textwidget custom-html-widget"><center> <div style="display: flex; flex-direction: column; justify-content: center; width: 300px;"> <div align="center"><a href="https://www.pharmaceuticalprocessingworld.com/sign-up-for-the-pharmaceutical-processing-enewsletter/" target="_blank"><img src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2023/12/PharmaceuticalProcessing-300x100-1.jpg" 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e({values:Mr(t,e.normalizeUnit),loc:xi.fromObject(n),conversionAccuracy:n.conversionAccuracy})},e.fromDurationLike=function(t){if(or(t))return e.fromMillis(t);if(e.isDuration(t))return t;if("object"==typeof t)return e.fromObject(t);throw new Fn("Unknown duration argument "+t+" of type "+typeof t)},e.fromISO=function(t,n){var r=Mi(t,[Pi,Yi])[0];return r?e.fromObject(r,n):e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.fromISOTime=function(t,n){var r=Mi(t,[ji,oo])[0];return r?e.fromObject(r,n):e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.invalid=function(t,n){if(void 0===n&&(n=null),!t)throw new Fn("need to specify a reason the Duration is invalid");var r=t instanceof Hr?t:new Hr(t,n);if(li.throwOnInvalid)throw new In(r);return new e({invalid:r})},e.normalizeUnit=function(e){var t={year:"years",years:"years",quarter:"quarters",quarters:"quarters",month:"months",months:"months",week:"weeks",weeks:"weeks",day:"days",days:"days",hour:"hours",hours:"hours",minute:"minutes",minutes:"minutes",second:"seconds",seconds:"seconds",millisecond:"milliseconds",milliseconds:"milliseconds"}[e?e.toLowerCase():e];if(!t)throw new Cn(e);return t},e.isDuration=function(e){return e&&e.isLuxonDuration||!1};var t=e.prototype;return t.toFormat=function(e,t){void 0===t&&(t={});var n=gn({},t,{floor:!1!==t.round&&!1!==t.floor});return this.isValid?Ur.create(this.loc,n).formatDurationFromString(this,e):"Invalid Duration"},t.toHuman=function(e){var t=this;void 0===e&&(e={});var n=ho.map((function(n){var r=t.values[n];return ir(r)?null:t.loc.numberFormatter(gn({style:"unit",unitDisplay:"long"},e,{unit:n.slice(0,-1)})).format(r)})).filter((function(e){return e}));return this.loc.listFormatter(gn({type:"conjunction",style:e.listStyle||"narrow"},e)).format(n)},t.toObject=function(){return this.isValid?gn({},this.values):{}},t.toISO=function(){if(!this.isValid)return null;var e="P";return 0!==this.years&&(e+=this.years+"Y"),0===this.months&&0===this.quarters||(e+=this.months+3*this.quarters+"M"),0!==this.weeks&&(e+=this.weeks+"W"),0!==this.days&&(e+=this.days+"D"),0===this.hours&&0===this.minutes&&0===this.seconds&&0===this.milliseconds||(e+="T"),0!==this.hours&&(e+=this.hours+"H"),0!==this.minutes&&(e+=this.minutes+"M"),0===this.seconds&&0===this.milliseconds||(e+=yr(this.seconds+this.milliseconds/1e3,3)+"S"),"P"===e&&(e+="T0S"),e},t.toISOTime=function(e){if(void 0===e&&(e={}),!this.isValid)return null;var t=this.toMillis();if(t<0||t>=864e5)return null;e=gn({suppressMilliseconds:!1,suppressSeconds:!1,includePrefix:!1,format:"extended"},e);var n=this.shiftTo("hours","minutes","seconds","milliseconds"),r="basic"===e.format?"hhmm":"hh:mm";e.suppressSeconds&&0===n.seconds&&0===n.milliseconds||(r+="basic"===e.format?"ss":":ss",e.suppressMilliseconds&&0===n.milliseconds||(r+=".SSS"));var i=n.toFormat(r);return e.includePrefix&&(i="T"+i),i},t.toJSON=function(){return this.toISO()},t.toString=function(){return this.toISO()},t.toMillis=function(){return this.as("milliseconds")},t.valueOf=function(){return this.toMillis()},t.plus=function(t){if(!this.isValid)return this;for(var n,r=e.fromDurationLike(t),i={},o=Dn(ho);!(n=o()).done;){var s=n.value;(lr(r.values,s)||lr(this.values,s))&&(i[s]=r.get(s)+this.get(s))}return yo(this,{values:i},!0)},t.minus=function(t){if(!this.isValid)return this;var n=e.fromDurationLike(t);return this.plus(n.negate())},t.mapUnits=function(e){if(!this.isValid)return this;for(var t={},n=0,r=Object.keys(this.values);n<r.length;n++){var i=r[n];t[i]=Tr(e(this.values[i],i))}return yo(this,{values:t},!0)},t.get=function(t){return this[e.normalizeUnit(t)]},t.set=function(t){return this.isValid?yo(this,{values:gn({},this.values,Mr(t,e.normalizeUnit))}):this},t.reconfigure=function(e){var t=void 0===e?{}:e,n=t.locale,r=t.numberingSystem,i=t.conversionAccuracy,o={loc:this.loc.clone({locale:n,numberingSystem:r})};return i&&(o.conversionAccuracy=i),yo(this,o)},t.as=function(e){return this.isValid?this.shiftTo(e).get(e):NaN},t.normalize=function(){if(!this.isValid)return this;var e=this.toObject();return function(e,t){mo.reduce((function(n,r){return ir(t[r])?n:(n&&vo(e,t,n,t,r),r)}),null)}(this.matrix,e),yo(this,{values:e},!0)},t.shiftTo=function(){for(var t=arguments.length,n=new Array(t),r=0;r<t;r++)n[r]=arguments[r];if(!this.isValid)return this;if(0===n.length)return this;n=n.map((function(t){return e.normalizeUnit(t)}));for(var i,o,s={},u={},a=this.toObject(),l=Dn(ho);!(o=l()).done;){var c=o.value;if(n.indexOf(c)>=0){i=c;var f=0;for(var d in u)f+=this.matrix[d][c]*u[d],u[d]=0;or(a[c])&&(f+=a[c]);var h=Math.trunc(f);for(var m in s[c]=h,u[c]=(1e3*f-1e3*h)/1e3,a)ho.indexOf(m)>ho.indexOf(c)&&vo(this.matrix,a,m,s,c)}else or(a[c])&&(u[c]=a[c])}for(var y in u)0!==u[y]&&(s[i]+=y===i?u[y]:u[y]/this.matrix[i][y]);return yo(this,{values:s},!0).normalize()},t.negate=function(){if(!this.isValid)return this;for(var e={},t=0,n=Object.keys(this.values);t<n.length;t++){var r=n[t];e[r]=0===this.values[r]?0:-this.values[r]}return yo(this,{values:e},!0)},t.equals=function(e){if(!this.isValid||!e.isValid)return!1;if(!this.loc.equals(e.loc))return!1;for(var t,n=Dn(ho);!(t=n()).done;){var r=t.value;if(i=this.values[r],o=e.values[r],!(void 0===i||0===i?void 0===o||0===o:i===o))return!1}var i,o;return!0},pn(e,[{key:"locale",get:function(){return this.isValid?this.loc.locale:null}},{key:"numberingSystem",get:function(){return this.isValid?this.loc.numberingSystem:null}},{key:"years",get:function(){return this.isValid?this.values.years||0:NaN}},{key:"quarters",get:function(){return this.isValid?this.values.quarters||0:NaN}},{key:"months",get:function(){return this.isValid?this.values.months||0:NaN}},{key:"weeks",get:function(){return this.isValid?this.values.weeks||0:NaN}},{key:"days",get:function(){return this.isValid?this.values.days||0:NaN}},{key:"hours",get:function(){return this.isValid?this.values.hours||0:NaN}},{key:"minutes",get:function(){return this.isValid?this.values.minutes||0:NaN}},{key:"seconds",get:function(){return this.isValid?this.values.seconds||0:NaN}},{key:"milliseconds",get:function(){return this.isValid?this.values.milliseconds||0:NaN}},{key:"isValid",get:function(){return null===this.invalid}},{key:"invalidReason",get:function(){return this.invalid?this.invalid.reason:null}},{key:"invalidExplanation",get:function(){return this.invalid?this.invalid.explanation:null}}]),e}();var go=function(){function e(e){this.s=e.start,this.e=e.end,this.invalid=e.invalid||null,this.isLuxonInterval=!0}e.invalid=function(t,n){if(void 0===n&&(n=null),!t)throw new Fn("need to specify a reason the Interval is invalid");var r=t instanceof Hr?t:new Hr(t,n);if(li.throwOnInvalid)throw new _n(r);return new e({invalid:r})},e.fromDateTimes=function(t,n){var r=gs(t),i=gs(n),o=function(e,t){return e&&e.isValid?t&&t.isValid?t<e?go.invalid("end before start","The end of an interval must be after its start, but you had start="+e.toISO()+" and end="+t.toISO()):null:go.invalid("missing or invalid end"):go.invalid("missing or invalid start")}(r,i);return null==o?new e({start:r,end:i}):o},e.after=function(t,n){var r=po.fromDurationLike(n),i=gs(t);return e.fromDateTimes(i,i.plus(r))},e.before=function(t,n){var r=po.fromDurationLike(n),i=gs(t);return e.fromDateTimes(i.minus(r),i)},e.fromISO=function(t,n){var r=(t||"").split("/",2),i=r[0],o=r[1];if(i&&o){var s,u,a,l;try{u=(s=ps.fromISO(i,n)).isValid}catch(e){u=!1}try{l=(a=ps.fromISO(o,n)).isValid}catch(e){l=!1}if(u&&l)return e.fromDateTimes(s,a);if(u){var c=po.fromISO(o,n);if(c.isValid)return e.after(s,c)}else if(l){var f=po.fromISO(i,n);if(f.isValid)return e.before(a,f)}}return e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.isInterval=function(e){return e&&e.isLuxonInterval||!1};var t=e.prototype;return t.length=function(e){return void 0===e&&(e="milliseconds"),this.isValid?this.toDuration.apply(this,[e]).get(e):NaN},t.count=function(e){if(void 0===e&&(e="milliseconds"),!this.isValid)return NaN;var t=this.start.startOf(e),n=this.end.startOf(e);return Math.floor(n.diff(t,e).get(e))+1},t.hasSame=function(e){return!!this.isValid&&(this.isEmpty()||this.e.minus(1).hasSame(this.s,e))},t.isEmpty=function(){return this.s.valueOf()===this.e.valueOf()},t.isAfter=function(e){return!!this.isValid&&this.s>e},t.isBefore=function(e){return!!this.isValid&&this.e<=e},t.contains=function(e){return!!this.isValid&&(this.s<=e&&this.e>e)},t.set=function(t){var n=void 0===t?{}:t,r=n.start,i=n.end;return this.isValid?e.fromDateTimes(r||this.s,i||this.e):this},t.splitAt=function(){var t=this;if(!this.isValid)return[];for(var n=arguments.length,r=new Array(n),i=0;i<n;i++)r[i]=arguments[i];for(var o=r.map(gs).filter((function(e){return t.contains(e)})).sort(),s=[],u=this.s,a=0;u<this.e;){var l=o[a]||this.e,c=+l>+this.e?this.e:l;s.push(e.fromDateTimes(u,c)),u=c,a+=1}return s},t.splitBy=function(t){var n=po.fromDurationLike(t);if(!this.isValid||!n.isValid||0===n.as("milliseconds"))return[];for(var r,i=this.s,o=1,s=[];i<this.e;){var u=this.start.plus(n.mapUnits((function(e){return e*o})));r=+u>+this.e?this.e:u,s.push(e.fromDateTimes(i,r)),i=r,o+=1}return s},t.divideEqually=function(e){return this.isValid?this.splitBy(this.length()/e).slice(0,e):[]},t.overlaps=function(e){return this.e>e.s&&this.s<e.e},t.abutsStart=function(e){return!!this.isValid&&+this.e==+e.s},t.abutsEnd=function(e){return!!this.isValid&&+e.e==+this.s},t.engulfs=function(e){return!!this.isValid&&(this.s<=e.s&&this.e>=e.e)},t.equals=function(e){return!(!this.isValid||!e.isValid)&&(this.s.equals(e.s)&&this.e.equals(e.e))},t.intersection=function(t){if(!this.isValid)return this;var n=this.s>t.s?this.s:t.s,r=this.e<t.e?this.e:t.e;return n>=r?null:e.fromDateTimes(n,r)},t.union=function(t){if(!this.isValid)return this;var n=this.s<t.s?this.s:t.s,r=this.e>t.e?this.e:t.e;return e.fromDateTimes(n,r)},e.merge=function(e){var t=e.sort((function(e,t){return e.s-t.s})).reduce((function(e,t){var n=e[0],r=e[1];return r?r.overlaps(t)||r.abutsStart(t)?[n,r.union(t)]:[n.concat([r]),t]:[n,t]}),[[],null]),n=t[0],r=t[1];return r&&n.push(r),n},e.xor=function(t){for(var n,r,i=null,o=0,s=[],u=t.map((function(e){return[{time:e.s,type:"s"},{time:e.e,type:"e"}]})),a=Dn((n=Array.prototype).concat.apply(n,u).sort((function(e,t){return e.time-t.time})));!(r=a()).done;){var l=r.value;1===(o+="s"===l.type?1:-1)?i=l.time:(i&&+i!=+l.time&&s.push(e.fromDateTimes(i,l.time)),i=null)}return e.merge(s)},t.difference=function(){for(var t=this,n=arguments.length,r=new Array(n),i=0;i<n;i++)r[i]=arguments[i];return e.xor([this].concat(r)).map((function(e){return t.intersection(e)})).filter((function(e){return e&&!e.isEmpty()}))},t.toString=function(){return this.isValid?"["+this.s.toISO()+" – "+this.e.toISO()+")":"Invalid Interval"},t.toISO=function(e){return this.isValid?this.s.toISO(e)+"/"+this.e.toISO(e):"Invalid Interval"},t.toISODate=function(){return this.isValid?this.s.toISODate()+"/"+this.e.toISODate():"Invalid Interval"},t.toISOTime=function(e){return this.isValid?this.s.toISOTime(e)+"/"+this.e.toISOTime(e):"Invalid Interval"},t.toFormat=function(e,t){var n=(void 0===t?{}:t).separator,r=void 0===n?" – ":n;return this.isValid?""+this.s.toFormat(e)+r+this.e.toFormat(e):"Invalid Interval"},t.toDuration=function(e,t){return this.isValid?this.e.diff(this.s,e,t):po.invalid(this.invalidReason)},t.mapEndpoints=function(t){return e.fromDateTimes(t(this.s),t(this.e))},pn(e,[{key:"start",get:function(){return this.isValid?this.s:null}},{key:"end",get:function(){return this.isValid?this.e:null}},{key:"isValid",get:function(){return null===this.invalidReason}},{key:"invalidReason",get:function(){return this.invalid?this.invalid.reason:null}},{key:"invalidExplanation",get:function(){return this.invalid?this.invalid.explanation:null}}]),e}(),wo=function(){function e(){}return e.hasDST=function(e){void 0===e&&(e=li.defaultZone);var t=ps.now().setZone(e).set({month:12});return!e.isUniversal&&t.offset!==t.set({month:6}).offset},e.isValidIANAZone=function(e){return Kr.isValidZone(e)},e.normalizeZone=function(e){return ni(e,li.defaultZone)},e.months=function(e,t){void 0===e&&(e="long");var n=void 0===t?{}:t,r=n.locale,i=void 0===r?null:r,o=n.numberingSystem,s=void 0===o?null:o,u=n.locObj,a=void 0===u?null:u,l=n.outputCalendar,c=void 0===l?"gregory":l;return(a||xi.create(i,s,c)).months(e)},e.monthsFormat=function(e,t){void 0===e&&(e="long");var n=void 0===t?{}:t,r=n.locale,i=void 0===r?null:r,o=n.numberingSystem,s=void 0===o?null:o,u=n.locObj,a=void 0===u?null:u,l=n.outputCalendar,c=void 0===l?"gregory":l;return(a||xi.create(i,s,c)).months(e,!0)},e.weekdays=function(e,t){void 0===e&&(e="long");var n=void 0===t?{}:t,r=n.locale,i=void 0===r?null:r,o=n.numberingSystem,s=void 0===o?null:o,u=n.locObj;return((void 0===u?null:u)||xi.create(i,s,null)).weekdays(e)},e.weekdaysFormat=function(e,t){void 0===e&&(e="long");var n=void 0===t?{}:t,r=n.locale,i=void 0===r?null:r,o=n.numberingSystem,s=void 0===o?null:o,u=n.locObj;return((void 0===u?null:u)||xi.create(i,s,null)).weekdays(e,!0)},e.meridiems=function(e){var t=(void 0===e?{}:e).locale,n=void 0===t?null:t;return xi.create(n).meridiems()},e.eras=function(e,t){void 0===e&&(e="short");var n=(void 0===t?{}:t).locale,r=void 0===n?null:n;return xi.create(r,null,"gregory").eras(e)},e.features=function(){return{relative:ur()}},e}();function ko(e,t){var n=function(e){return e.toUTC(0,{keepLocalTime:!0}).startOf("day").valueOf()},r=n(t)-n(e);return Math.floor(po.fromMillis(r).as("days"))}function bo(e,t,n,r){var i=function(e,t,n){for(var r,i,o={},s=0,u=[["years",function(e,t){return t.year-e.year}],["quarters",function(e,t){return t.quarter-e.quarter}],["months",function(e,t){return t.month-e.month+12*(t.year-e.year)}],["weeks",function(e,t){var n=ko(e,t);return(n-n%7)/7}],["days",ko]];s<u.length;s++){var a=u[s],l=a[0],c=a[1];if(n.indexOf(l)>=0){var f;r=l;var d,h=c(e,t);(i=e.plus(((f={})[l]=h,f)))>t?(e=e.plus(((d={})[l]=h-1,d)),h-=1):e=i,o[l]=h}}return[e,o,i,r]}(e,t,n),o=i[0],s=i[1],u=i[2],a=i[3],l=t-o,c=n.filter((function(e){return["hours","minutes","seconds","milliseconds"].indexOf(e)>=0}));if(0===c.length){var f;if(u<t)u=o.plus(((f={})[a]=1,f));u!==o&&(s[a]=(s[a]||0)+l/(u-o))}var d,h=po.fromObject(s,r);return c.length>0?(d=po.fromMillis(l,r)).shiftTo.apply(d,c).plus(h):h}var xo={arab:"[٠-٩]",arabext:"[۰-۹]",bali:"[᭐-᭙]",beng:"[০-৯]",deva:"[०-९]",fullwide:"[０-９]",gujr:"[૦-૯]",hanidec:"[〇|一|二|三|四|五|六|七|八|九]",khmr:"[០-៩]",knda:"[೦-೯]",laoo:"[໐-໙]",limb:"[᥆-᥏]",mlym:"[൦-൯]",mong:"[᠐-᠙]",mymr:"[၀-၉]",orya:"[୦-୯]",tamldec:"[௦-௯]",telu:"[౦-౯]",thai:"[๐-๙]",tibt:"[༠-༩]",latn:"\\d"},So={arab:[1632,1641],arabext:[1776,1785],bali:[6992,7001],beng:[2534,2543],deva:[2406,2415],fullwide:[65296,65303],gujr:[2790,2799],khmr:[6112,6121],knda:[3302,3311],laoo:[3792,3801],limb:[6470,6479],mlym:[3430,3439],mong:[6160,6169],mymr:[4160,4169],orya:[2918,2927],tamldec:[3046,3055],telu:[3174,3183],thai:[3664,3673],tibt:[3872,3881]},To=xo.hanidec.replace(/[\[|\]]/g,"").split("");function Mo(e,t){var n=e.numberingSystem;return void 0===t&&(t=""),new RegExp(""+xo[n||"latn"]+t)}function Oo(e,t){return void 0===t&&(t=function(e){return e}),{regex:e,deser:function(e){var n=e[0];return t(function(e){var t=parseInt(e,10);if(isNaN(t)){t="";for(var n=0;n<e.length;n++){var r=e.charCodeAt(n);if(-1!==e[n].search(xo.hanidec))t+=To.indexOf(e[n]);else for(var i in So){var o=So[i],s=o[0],u=o[1];r>=s&&r<=u&&(t+=r-s)}}return parseInt(t,10)}return t}(n))}}}var Do="[ "+String.fromCharCode(160)+"]",No=new RegExp(Do,"g");function Eo(e){return e.replace(/\./g,"\\.?").replace(No,Do)}function _o(e){return e.replace(/\./g,"").replace(No," ").toLowerCase()}function Io(e,t){return null===e?null:{regex:RegExp(e.map(Eo).join("|")),deser:function(n){var r=n[0];return e.findIndex((function(e){return _o(r)===_o(e)}))+t}}}function Vo(e,t){return{regex:e,deser:function(e){return Sr(e[1],e[2])},groups:t}}function Co(e){return{regex:e,deser:function(e){return e[0]}}}var Fo={year:{"2-digit":"yy",numeric:"yyyyy"},month:{numeric:"M","2-digit":"MM",short:"MMM",long:"MMMM"},day:{numeric:"d","2-digit":"dd"},weekday:{short:"EEE",long:"EEEE"},dayperiod:"a",dayPeriod:"a",hour:{numeric:"h","2-digit":"hh"},minute:{numeric:"m","2-digit":"mm"},second:{numeric:"s","2-digit":"ss"}};var zo=null;function Ao(e,t){if(e.literal)return e;var n=Ur.macroTokenToFormatOpts(e.val);if(!n)return e;var r=Ur.create(t,n).formatDateTimeParts((zo||(zo=ps.fromMillis(1555555555555)),zo)).map((function(e){return function(e,t,n){var r=e.type,i=e.value;if("literal"===r)return{literal:!0,val:i};var o=n[r],s=Fo[r];return"object"==typeof s&&(s=s[o]),s?{literal:!1,val:s}:void 0}(e,0,n)}));return r.includes(void 0)?e:r}function Lo(e,t,n){var r=function(e,t){var n;return(n=Array.prototype).concat.apply(n,e.map((function(e){return Ao(e,t)})))}(Ur.parseFormat(n),e),i=r.map((function(t){return n=t,i=Mo(r=e),o=Mo(r,"{2}"),s=Mo(r,"{3}"),u=Mo(r,"{4}"),a=Mo(r,"{6}"),l=Mo(r,"{1,2}"),c=Mo(r,"{1,3}"),f=Mo(r,"{1,6}"),d=Mo(r,"{1,9}"),h=Mo(r,"{2,4}"),m=Mo(r,"{4,6}"),y=function(e){return{regex:RegExp((t=e.val,t.replace(/[\-\[\]{}()*+?.,\\\^$|#\s]/g,"\\$&"))),deser:function(e){return e[0]},literal:!0};var t},v=function(e){if(n.literal)return y(e);switch(e.val){case"G":return Io(r.eras("short",!1),0);case"GG":return Io(r.eras("long",!1),0);case"y":return Oo(f);case"yy":case"kk":return Oo(h,br);case"yyyy":case"kkkk":return Oo(u);case"yyyyy":return Oo(m);case"yyyyyy":return Oo(a);case"M":case"L":case"d":case"H":case"h":case"m":case"q":case"s":case"W":return Oo(l);case"MM":case"LL":case"dd":case"HH":case"hh":case"mm":case"qq":case"ss":case"WW":return Oo(o);case"MMM":return Io(r.months("short",!0,!1),1);case"MMMM":return Io(r.months("long",!0,!1),1);case"LLL":return Io(r.months("short",!1,!1),1);case"LLLL":return Io(r.months("long",!1,!1),1);case"o":case"S":return Oo(c);case"ooo":case"SSS":return Oo(s);case"u":return Co(d);case"uu":return Co(l);case"uuu":case"E":case"c":return Oo(i);case"a":return Io(r.meridiems(),0);case"EEE":return Io(r.weekdays("short",!1,!1),1);case"EEEE":return Io(r.weekdays("long",!1,!1),1);case"ccc":return Io(r.weekdays("short",!0,!1),1);case"cccc":return Io(r.weekdays("long",!0,!1),1);case"Z":case"ZZ":return Vo(new 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e=JSON.parse(this.responseText).intradayPricing,t=0,n=yn.DateTime.now();e.length>0&&(t=parseFloat(e[e.length-1].price).toFixed(2),n=yn.DateTime.fromISO(e[e.length-1].time));document.getElementById("md-current-price").innerHTML="$"+t;document.getElementById("md-current-time").innerHTML=n.toLocaleString(yn.DateTime.DATETIME_FULL);const r=[],i=[];e.forEach((e=>{const{price:t,time:n}=e,o=yn.DateTime.fromISO(n),s=parseFloat(t).toFixed(2);r.push(o.toUnixInteger()),i.push(s)}));const o=document.getElementById("md-intraday-chart"),s=new mn({width:300,height:120,class:"spark",pxAlign:!1,cursor:{show:!1},select:{show:!1},legend:{show:!1},scales:{x:{time:!1}},axes:[{show:!1},{show:!1}],series:[{},{stroke:"#ec5b2e",fill:"#ffb39c"}]},[r,i]).ctx.canvas;o.parentNode.append(s)}},ws.open("GET","https://medtech100.com/md100/json/pricing",!0),ws.send(); //# sourceMappingURL=index.80f28a61.js.map </script> </head> <body> <div id="md-tech-ad"> <table class="md-table" align="center" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="100%"> <div class="md-align"> <img id="md-logo" class="md-margin" src="https://images.designworldonline.com/newsletters/images/ee034d8d8274c1ee5e8111f11cf1be49.png" alt="Medtech 100 logo"> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align"> <div class="margin-text"> <span style="font-weight:600;color:#e06636!important;font-size:16px!important;line-height:14px!important"> Market Summary > Current Price </span> </div> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align" id="md-content-container"> <div id="md-current-price"></div> <div id="md-current-time"></div> <div id="md-chart-container"> <div id="md-intraday-chart"></div> </div> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align"> <div class="md-margin-text"> <span style="font-size:13px;line-height:15px!important"> The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing. </span> </div> </div> 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