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AG Prof. Maximilian Waldner - Medizin 1 | Uniklinikum Erlangen

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Mircea Chiriac / Prof. Dr. med. Neurath"><span>AG Dr. med. dent. Mircea Chiriac / Prof. Dr. med. Neurath</span></a><ul id="navlist1022372" class="navbar__list collapse "><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/about-the-lab/" class="navbar__link " title="About the lab"><span>About the lab</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/projects/" class="navbar__link " title="Projects"><span>Projects</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/funding/" class="navbar__link " title="Funding"><span>Funding</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/lab-members/" class="navbar__link " title="Lab Members"><span>Lab Members</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/open-positions/" class="navbar__link " title="Open Positions"><span>Open Positions</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/protocols/" class="navbar__link " title="Protocols"><span>Protocols</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/publications/" class="navbar__link " title="Publications"><span>Publications</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/useful-links/" class="navbar__link " title="Useful links"><span>Useful links</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/contact/" class="navbar__link " title="Contact"><span>Contact</span></a></li></ul><button type="button" class="btn toggle" data-bs-toggle="collapse" data-bs-target="#navlist1022372" aria-expanded="false" aria-controls="navlist1022372" ></button></li><li class="navbar__item has-children active"><a href="/forschung/arbeitsgruppen/ag-prof-m-waldner/" class="navbar__link active" title="AG Prof. Maximilian Waldner"><span class="icon icon-arrow_right d-md-none"></span><span>AG Prof. Maximilian Waldner <span class="sr-only">(current)</span></span></a><ul id="navlist13562" class="navbar__list collapse show"><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-prof-m-waldner/projekte/" class="navbar__link " title="Projekte"><span>Projekte</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-prof-m-waldner/mitarbeiter/" class="navbar__link " title="Mitarbeiter"><span>Mitarbeiter</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-prof-m-waldner/foerderung/" class="navbar__link " title="F枚rderung"><span>F枚rderung</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-prof-m-waldner/publikationen/" class="navbar__link " title="Publikationen"><span>Publikationen</span></a></li></ul><button type="button" class="btn toggle" data-bs-toggle="collapse" data-bs-target="#navlist13562" aria-expanded="true" aria-controls="navlist13562" ></button></li><li class="navbar__item has-children"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/" class="navbar__link " title="AG PD Dr. Benno Weigmann"><span>AG PD Dr. Benno Weigmann</span></a><ul id="navlist6940" class="navbar__list collapse "><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/projekte/" class="navbar__link " title="Projekte"><span>Projekte</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/mitarbeiter/" class="navbar__link " title="Mitarbeiter"><span>Mitarbeiter</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/foerderung/" class="navbar__link " title="F枚rderung"><span>F枚rderung</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/auszeichnungen/" class="navbar__link " title="Auszeichnungen"><span>Auszeichnungen</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/publikationen/" class="navbar__link " 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title="Kontakt"><span>Kontakt</span></a></li><li class="navbar__item flag "><a href="https://www.transfusionsmedizin.uk-erlangen.de/blutspende/" title="Blutspende"><span>Blutspende</span></a></li><li class="navbar__item flag "><a href="/anfahrt/" title="Anfahrt"><span>Anfahrt</span></a></li></ul></div></nav></div></header><div class="frame-container frame-container-large frame-type-intro-bg"><div class="ratio ratio-5x1"><div class="frame-has-backgroundimage"><div class="frame-backgroundimage-container"><div id="frame-backgroundimage-13562" class="frame-backgroundimage"></div></div></div></div><div class="frame-type-intro"><div class="frame-container frame-container-default"><div class="frame-inner"><header class="frame-header"><h1 class="element-header mb-2"><span>AG Prof. Maximilian Waldner</span></h1></header></div></div></div></div><nav class="breadcrumb-section" aria-label="Brotkr眉melnavigation"><div class="container"><p class="sr-only" id="breadcrumb">Sie sind hier:</p><ol class="breadcrumb"><li class="breadcrumb-item"><a class="breadcrumb-link" href="https://www.uk-erlangen.de/" title="Zur Startseite des Universit盲tsklinikums Erlangen"><svg height="37" xmlns="http://www.w3.org/2000/svg" viewBox="0,0,63,64"><g><path d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" opacity="1" fill="#00a579"/><path d="M41.876+21.0438L20.938+21.0438L20.938+42.3789L41.876+42.3789L41.876+21.0438Z" opacity="1" fill="#2761ab"/><path d="M41.876+42.3788L20.938+42.3788L20.938+63.7138L41.876+63.7138L41.876+42.3788Z" opacity="1" fill="#00B1EB"/><path d="M41.876-0.29126L20.938-0.29126L20.938+21.0451L41.876+21.0451L41.876-0.29126Z" opacity="1" fill="#00B1EB"/></g></svg></a></li><li class="breadcrumb-item icon-arrow_right"><a class="breadcrumb-link" href="/" title="Medizin 1"><span class="breadcrumb-text">Medizin 1</span></a></li><li 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class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Arbeitsgruppe Prof. Dr. med. Maximilian Waldner</span></h2><h3 class="element-subheader "><span>Mukosale Entz眉ndung und Tumorentstehung: Optische Bildgebung und molekulare Pathogenese</span></h3></div></div></div></div></div></div><div id="c85201" class=" frame frame-default frame-type-custom_linklist frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="d-grid link-items layout-simple "><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-prof-m-waldner/" class="stretched-link">Allgemein</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-prof-m-waldner/projekte/" class="stretched-link">Projekte</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-prof-m-waldner/mitarbeiter/" class="stretched-link">Mitarbeiter</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-prof-m-waldner/foerderung/" class="stretched-link">F枚rderung</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-prof-m-waldner/publikationen/" class="stretched-link">Publikationen</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div></div></div></div></div></div></div></div><div class="section section-default"><div id="c39244" class=" frame frame-default frame-type-textpic frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="textpic textpic-above"><div class="textpic-item textpic-gallery"></div><div class="textpic-item textpic-text"><p> In unserer Arbeitsgruppe untersuchen wir molekulare Mechanismen der Entstehung chronisch-entz眉ndlicher Darmerkrankungen und des daraus resultierenden Darmkrebsrisikos. Neben der Identifizierung und Charakterisierung krankheitsrelevanter Signalwege steht die Entwicklung neuer optischer Bildgebungsverfahren zur besseren Diagnostik im Vordergrund. Diese Arbeiten erfolgen in Zusammenarbeit mit der Technischen Fakult盲t im Rahmen der Erlangen Graduate School in Advanced Optical Technologies (SAOT). Die neu entwickelten Bildgebungstechniken werden hinsichtlich Ihrer Eignung als neue klinische Diagnoseverfahren z.B. in der gastrointestinalen Endoskopie untersucht.</p></div></div></div></div></div></div></div><div id="c39245" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Chronische Darmentz眉ndungen</span></h2></div><p> Chronisch entz眉ndliche Darmerkrankungen (CED) wie Morbus Crohn und Colitis ulcerosa f眉hren bei betroffenen Patienten zu einer chronischen Entz眉ndung des Magen-Darm-Trakts, die mit erheblichen klinischen Beschwerden und dem Risiko verschiedener Komplikationen verbunden ist. Die Erkrankungen treten h盲ufig bereits im jungen Alter auf, verlaufen teilweise in Sch眉ben und k枚nnen 眉ber viele Jahre oder sogar Jahrzehnte bestehen. <br>Trotz intensiver Forschung werden die molekularen Mechanismen, die f眉r die Entstehung der CED verantwortlich sind, bisher nur in Grundz眉gen verstanden. Aktuelle Therapien f眉hren zu einer unspezifischen Hemmung des Immunsystems, die mit erheblichen Nebenwirkungen verbunden und nicht bei allen Patienten wirksam ist. Ein Ziel unserer Arbeitsgruppe ist daher die Erforschung molekularer Mechanismen der Krankheitsentstehung chronisch entz眉ndlicher Darmerkrankungen mit dem Ziel neue Therapieoptionen zu identifizieren</p></div></div></div></div></div><div id="c39246" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Entz眉ndungs-assoziierte Tumorentstehung: Das Colitis-assoziierte colorectale Carcinom</span></h2></div><p>Eine bedrohliche Komplikation der CED ist die Entstehung eines colorectalen Carcinoms (CRC). Sowohl Colitis ulcerosa als auch Morbus Crohn f眉hren in Abh盲ngigkeit von der Auspr盲gung, Ausdehnung und Dauer der Entz眉ndung des Dickdarms zu einem erh枚hten Risiko an einem KRK zu erkranken. Obwohl schon seit vielen Jahrzehnten bekannt ist, dass chronische Entz眉ndungen die Tumorentstehung f枚rdern k枚nnen, sind die genauen Mechanismen die zur Entstehung des Colitis-assoziierten Carcinoms (CAC) f眉hren weitgehend unbekannt. <br>Da die Therapie des kolorektalen Karzinoms in fortgeschrittenen Stadien teilweise nur noch sehr geringe Heilungschancen hat, k枚nnte ein besseres Verst盲ndnis der Entz眉ndungs-assoziierten Tumorentstehung zu neuen Therapieformen f眉hren, die bereits die Tumorentstehung verhindern. Aus diesem Grund untersucht unsere Arbeitsgruppe den Einfluss chronischer Entz眉ndungen auf die Darmkrebsentstehung.</p></div></div></div></div></div><div id="c39247" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Endoskopie zur Diagnostik chronisch entz眉ndlicher Darmerkrankungen und zur Tumorvorsorge</span></h2></div><p> Die Endoskopie stellt nach wie vor den Goldstandard bei der klinischen Beurteilung der Krankheitsaktivit盲t chronisch entz眉ndlicher Darmerkrankungen und bei der Darmkrebsvorsorge dar. Obwohl verschiedene technische Entwicklungen der vergangenen Jahre (z.B. HD-Endoskopie, Chromoendoskopie etc.) eine kontinuierliche Verbesserung der Diagnosestellung mit Hilfe der Endoskopie erm枚glicht haben, werden trotz dieser Verfahren nicht alle Krankheitsbilder korrekt eingesch盲tzt und nicht alle Tumorvorstufen rechtzeitig erkannt.<br>In dieser Hinsicht stellen verschiedene optische Bildgebungsverfahren (Multiphotonen-Mikroskopie, hyperspektrale Bildgebung, Raman-Spektroskopie etc.), die aktuell vorwiegend in der Grundlagenforschung genutzt werden, vielversprechende Ans盲tze f眉r eine verbesserte Diagnostik dar. Ein Ziel unserer Arbeitsgruppe ist daher die Beurteilung des Nutzungspotentials dieser Techniken f眉r die Beurteilung der Darmentz眉ndung und der Fr眉herkennung des CRCs (<i>Immunophysics</i>).</p></div></div></div></div></div><div id="c39258" class=" frame frame-default frame-type-textpic frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="textpic textpic-below"><div class="textpic-item textpic-gallery"><div class="gallery-row"><div class="gallery-item gallery-item-size-1"><div class="image-wrap"><figure class="image"><div class="position-relative"><picture class=""><source data-variant="default" data-maxwidth="1570" media="(min-width: 1600px)" 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