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<!DOCTYPE html> <html lang="de"> <head> <meta charset="utf-8">  <title>AG PD Dr. Clemens Neufert - Medizin 1 | Uniklinikum Erlangen</title> <meta http-equiv="x-ua-compatible" content="IE=edge"> <meta name="generator" content="TYPO3 CMS"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1"> <meta name="robots" content="index,follow"> <meta name="twitter:card" content="summary"> <meta name="apple-mobile-web-app-capable" content="no"> <meta name="google" content="notranslate"> <link rel="stylesheet" href="/_assets/d62557c271d06262fbb7ce0981266e2f/Css/auto-complete.1732120249.css" media="all"> <link rel="stylesheet" href="/_assets/db5fd2ca3057ef07b5244af171451057/Css/ods_osm.1714687028.css" media="all"> <link rel="stylesheet" href="/_frontend/website/bundled/css/default.6c6d42ec.1730828947.css" media="all"> <style> #frame-backgroundimage-6944 { background-image: url('/fileadmin/_processed_/7/b/csm_slider_m1_intensiv_0c626630cb.jpg'); } @media (min-width: 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href="/forschung/arbeitsgruppen/ag-prof-j-siebler/" class="navbar__link " title="AG Prof. J眉rgen Siebler"><span>AG Prof. J眉rgen Siebler</span></a></li><li class="navbar__item has-children"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/" class="navbar__link " title="AG Dr. med. dent. Mircea Chiriac / Prof. Dr. med. Neurath"><span>AG Dr. med. dent. Mircea Chiriac / Prof. Dr. med. Neurath</span></a><ul id="navlist1022372" class="navbar__list collapse "><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/about-the-lab/" class="navbar__link " title="About the lab"><span>About the lab</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/projects/" class="navbar__link " title="Projects"><span>Projects</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/funding/" class="navbar__link " title="Funding"><span>Funding</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/lab-members/" class="navbar__link " title="Lab Members"><span>Lab Members</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/open-positions/" class="navbar__link " title="Open Positions"><span>Open Positions</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-neurathchiriac/protocols/" 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Weigmann</span></a><ul id="navlist6940" class="navbar__list collapse "><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/projekte/" class="navbar__link " title="Projekte"><span>Projekte</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/mitarbeiter/" class="navbar__link " title="Mitarbeiter"><span>Mitarbeiter</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/foerderung/" class="navbar__link " title="F枚rderung"><span>F枚rderung</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/auszeichnungen/" class="navbar__link " title="Auszeichnungen"><span>Auszeichnungen</span></a></li><li class="navbar__item"><a href="/forschung/arbeitsgruppen/ag-pd-dr-b-weigmann/publikationen/" class="navbar__link " title="Publikationen"><span>Publikationen</span></a></li></ul><button type="button" class="btn toggle" data-bs-toggle="collapse" 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title="脰ffnet den Sprachumschalter, um eine andere Sprache zu w盲hlen."><span class="lang-DE"></span><span class="icon icon-arrow_right d-none d-md-inline-block"></span></a></li><li class="text-muted collapse"></li><li class="text-muted collapse"></li><li class="text-muted collapse"></li></ul></div></div><div class="d-md-none navbar-info p-3 pt-0"><ul class="navbar__list"><li class="navbar__item flag"><a class="navbar-info__emergency text-danger" tabindex="3" href="/notfall/"><span> Notfall </span></a></li><li class="navbar__item flag "><a href="https://www.uk-erlangen.de/einrichtungen/klinikumsvorstand/qualitaetsmanagement/lob-und-kritik/" title="Lob und Kritik"><span>Lob und Kritik</span></a></li><li class="navbar__item flag "><a href="/kontakt/" title="Kontakt"><span>Kontakt</span></a></li><li class="navbar__item flag "><a href="https://www.transfusionsmedizin.uk-erlangen.de/blutspende/" title="Blutspende"><span>Blutspende</span></a></li><li class="navbar__item flag "><a href="/anfahrt/" title="Anfahrt"><span>Anfahrt</span></a></li></ul></div></nav></div></header><div class="frame-container frame-container-large frame-type-intro-bg"><div class="ratio ratio-5x1"><div class="frame-has-backgroundimage"><div class="frame-backgroundimage-container"><div id="frame-backgroundimage-6944" class="frame-backgroundimage"></div></div></div></div><div class="frame-type-intro"><div class="frame-container frame-container-default"><div class="frame-inner"><header class="frame-header"><h1 class="element-header mb-2"><span>AG PD Dr. Clemens Neufert</span></h1></header></div></div></div></div><nav class="breadcrumb-section" aria-label="Brotkr眉melnavigation"><div class="container"><p class="sr-only" id="breadcrumb">Sie sind hier:</p><ol class="breadcrumb"><li class="breadcrumb-item"><a class="breadcrumb-link" href="https://www.uk-erlangen.de/" title="Zur Startseite des Universit盲tsklinikums Erlangen"><svg height="37" xmlns="http://www.w3.org/2000/svg" viewBox="0,0,63,64"><g><path d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" opacity="1" fill="#00a579"/><path d="M41.876+21.0438L20.938+21.0438L20.938+42.3789L41.876+42.3789L41.876+21.0438Z" opacity="1" fill="#2761ab"/><path d="M41.876+42.3788L20.938+42.3788L20.938+63.7138L41.876+63.7138L41.876+42.3788Z" opacity="1" fill="#00B1EB"/><path d="M41.876-0.29126L20.938-0.29126L20.938+21.0451L41.876+21.0451L41.876-0.29126Z" opacity="1" fill="#00B1EB"/></g></svg></a></li><li class="breadcrumb-item icon-arrow_right"><a class="breadcrumb-link" href="/" title="Medizin 1"><span class="breadcrumb-text">Medizin 1</span></a></li><li class="breadcrumb-item icon-arrow_right "><a class="breadcrumb-link" href="/forschung/" title="Forschung"><span class="breadcrumb-text">Forschung</span></a></li><li class="breadcrumb-item icon-arrow_right "><a class="breadcrumb-link" href="/forschung/arbeitsgruppen/" title="Arbeitsgruppen"><span class="breadcrumb-text">Arbeitsgruppen</span></a></li><li class="breadcrumb-item icon-arrow_right active" aria-current="page"><span class="breadcrumb-text">AG PD Dr. Clemens Neufert</span></li></ol></div></nav><main id="page-content" class="bp-page-content main-section"><div class="section section-before-content"><div id="c13312" class=" frame frame-default frame-type-header frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Arbeitsgruppe PD Dr. med. Clemens Neufert, PhD</span></h2><h3 class="element-subheader "><span>Molekulare Krankheitsprozesse und neue Therapiestrategien bei kolorektalen Karzinomen und Darmentz眉ndungen</span></h3></div></div></div></div></div></div><div id="c85180" class=" frame frame-default frame-type-custom_linklist frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="d-grid link-items layout-simple "><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-c-neufert/" class="stretched-link">Allgemein</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-c-neufert/projekte/" class="stretched-link">Projekte</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-c-neufert/mitarbeiter/" class="stretched-link">Mitarbeiter</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-c-neufert/foerderung/" class="stretched-link">F枚rderung</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-c-neufert/publikationen/" class="stretched-link">Publikationen</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div></div></div></div></div></div></div></div><div class="section section-default"><div id="c13314" class=" frame frame-default frame-type-textpic frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="textpic textpic-left imageorient-26"><div class="textpic-item textpic-gallery"><div class="gallery-row"><div class="gallery-item gallery-item-size-1"><div class="image-wrap"><figure class="image"><div class="position-relative"><picture class=""><source data-variant="default" data-maxwidth="765" media="(min-width: 1600px)" srcset="/fileadmin/einrichtungen/medizin_1/forschung/Gruppenbilder/AG_Neufert/DSC01139AG_Neufert_Treppe.jpg 1x"><source data-variant="xlarge" data-maxwidth="595" media="(min-width: 1400px)" srcset="/fileadmin/einrichtungen/medizin_1/forschung/Gruppenbilder/AG_Neufert/DSC01139AG_Neufert_Treppe.jpg 1x"><source data-variant="large" data-maxwidth="595" media="(min-width: 1260px)" srcset="/fileadmin/einrichtungen/medizin_1/forschung/Gruppenbilder/AG_Neufert/DSC01139AG_Neufert_Treppe.jpg 1x"><source data-variant="medium" data-maxwidth="477" media="(min-width: 1024px)" srcset="/fileadmin/einrichtungen/medizin_1/forschung/Gruppenbilder/AG_Neufert/DSC01139AG_Neufert_Treppe.jpg 1x"><source data-variant="small" data-maxwidth="690" media="(min-width: 720px)" srcset="/fileadmin/einrichtungen/medizin_1/forschung/Gruppenbilder/AG_Neufert/DSC01139AG_Neufert_Treppe.jpg 1x"><source data-variant="extrasmall" data-maxwidth="690" srcset="/fileadmin/einrichtungen/medizin_1/forschung/Gruppenbilder/AG_Neufert/DSC01139AG_Neufert_Treppe.jpg 1x"><img class="img-fluid" loading="lazy" src="/fileadmin/_processed_/f/7/csm_DSC01139AG_Neufert_Treppe_59d253518d.jpg" width="765" height="627" title="" alt=""></picture></div></figure></div></div></div></div><div class="textpic-item textpic-text"><p>Unsere Arbeitsgruppe befasst sich mit der Erforschung von Darmerkrankungen. Im Zentrum unseres Interesses stehen dabei das kolorektale Karzinom (Darmkrebs) sowie chronisch entz眉ndliche Darmerkrankungen.</p><h2>Darmkrebs</h2><p> </p><p>Das kolorektale Karzinom geh枚rt zu den h盲ufigsten b枚sartigen Erkrankungen bei Frauen und M盲nnern in Mitteleuropa. Allein in Deutschland erkranken j盲hrlich etwa 70 000 Menschen neu. Die Faktoren, die zum Ausbruch der Erkrankung und deren Fortschreiten f眉hren k枚nnen, sind bislang nur unvollst盲ndig verstanden. Nach derzeitigem Kenntnisstand finden sich beim Darmkrebs diverse Untergruppen, die u.a. durch Unterschiede im biologischen Verhalten gekennzeichnet sind.</p></div></div></div></div></div></div></div><div id="c85177" class=" frame frame-default frame-type-media frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="gallery-row"><div class="gallery-item gallery-item-size-2"><figure class="video"><div class="ratio ratio-16x9" id="video_85177_61628"><style>#video_85177_61628{background-image: url(/fileadmin/_processed_/2/1/csm_STAT3_activation_in_cancer-associated_fibroblasts_promotes_colorectal_tumour_development_1511c20499.png);}</style><div class="video-wrapper js-video_wrapper"><div class="video-trigger js-video_trigger"><p>Mit dem Laden des Videos erkl盲ren Sie sich einverstanden, dass Ihre Daten an YouTube 眉bermittelt werden und Sie die Datenschutzerkl盲rung gelesen haben.</p><button class="btn btn-primary js-video_privacy_check">Akzeptieren</button></div><iframe class="js-video_iframe" data-src="https://www.youtube-nocookie.com/embed/cQWzIOXVDeg?rel=0&showinfo=0" title="STAT3 activation in cancer-associated fibroblasts promotes colorectal tumour development" frameborder="0" allowfullscreen="allowfullscreen"></iframe></div></div></figure></div></div></div></div></div></div></div><div id="c70945" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><p> </p><p>Trotz Behandlungsfortschritten in den vergangenen Jahren bestehen gute Heilungsaussichten f眉r das kolorektale Karzinom weiterhin nur bei Diagnose im Fr眉hstadium. Zudem k枚nnen die derzeit eingesetzten Medikamente schwere Nebenwirkungen, z.B. Durchfall oder L盲hmung der k枚rpereigenen Abwehr hervorrufen, da sie neben den Krebszellen oft auch gesunde Zellen attackieren.<br> Um zuk眉nftig 眉ber bessere Therapiem枚glichkeiten verf眉gen zu k枚nnen, beteiligen wir uns intensiv an der Erforschung der Krankheitsmechanismen des kolorektalen Karzinoms.</p><p> </p><p> </p></div></div></div></div></div><div id="c13317" class=" frame frame-default frame-type-image frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="gallery-row"><div class="gallery-item gallery-item-size-2"><div class="image-wrap"><figure class="image"><div class="position-relative"><picture class=""><source data-variant="default" data-width="781" data-height="585" media="(min-width: 1600px)" srcset="/fileadmin/_processed_/f/f/csm_Unbenannt-1_ger_221dec009e.jpg 1x"><source data-variant="xlarge" data-width="611" data-height="458" media="(min-width: 1400px)" srcset="/fileadmin/_processed_/f/f/csm_Unbenannt-1_ger_195d0622f9.jpg 1x"><source data-variant="large" data-width="611" data-height="458" media="(min-width: 1260px)" srcset="/fileadmin/_processed_/f/f/csm_Unbenannt-1_ger_195d0622f9.jpg 1x"><source data-variant="medium" data-width="493" data-height="369" media="(min-width: 1024px)" srcset="/fileadmin/_processed_/f/f/csm_Unbenannt-1_ger_9a3b51cc63.jpg 1x"><source data-variant="small" data-width="341" data-height="255" media="(min-width: 720px)" srcset="/fileadmin/_processed_/f/f/csm_Unbenannt-1_ger_98e88e6e34.jpg 1x"><source data-variant="extrasmall" data-width="682" data-height="511" srcset="/fileadmin/_processed_/f/f/csm_Unbenannt-1_ger_c0a255ec5e.jpg 1x"><img class="img-fluid" loading="lazy" src="/fileadmin/_processed_/f/f/csm_Unbenannt-1_ger_626a292df8.jpg" width="781" height="585" title="" alt=""></picture></div></figure></div></div></div></div></div></div></div></div><div id="c70958" class=" frame frame-default frame-type-div frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><hr></div></div></div></div></div><div id="c13318" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Chronisch entz眉ndliche Darmerkrankungen</span></h2></div><p>Chronisch entz眉ndliche Darmerkrankungen (CED) mit den Hauptvertretern Morbus Crohn und Colitis ulcerosa sind weit verbreitet. Aktuelle Sch盲tzungen gehen f眉r Deutschland von etwa 320.000 betroffenen Personen aus. Bei CED findet sich meist ein schubartiger Krankheitsverlauf mit belastenden Beschwerden wie Durchfall und Bauchschmerzen. Dabei ist bemerkenswert, dass oft bereits junge Menschen erkranken. Die Ursachen von CED sind ungekl盲rt. Nach einem derzeit g眉ltigen Modell zeichnet u.a. eine 眉berschie脽ende Immunreaktion bei genetisch besonders veranlagten Personen unter Beteiligung von Faktoren der eigenen Darmflora verantwortlich. Eine urs盲chliche Behandlung von CED ist bislang nicht m枚glich. Die derzeit verf眉gbaren Medikamente sind nur begrenzt wirksam und entfalten ihre Effekte zumeist relativ unspezifisch durch eine Hemmung des k枚rpereigenen Abwehrsystems.<br>Mit dem Ziel, neue - wirkstarke und nebenwirkungsarme - Behandlungsm枚glichkeiten einsetzen zu k枚nnen, forschen wir intensiv an den Krankheitsmechanismen von CED.</p></div></div></div></div></div></div><div class="section section-before-footer"><div id="c79995" class=" frame frame-default frame-type-custom_logoslider frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="logoslider-wrapper logoslider-wrapper-"><div class="swiper-container logoslider "><div class="swiper-wrapper"><div class="swiper-slide"><a href="https://www.med.fau.de" target="_blank" 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