CCMI | CELL MAPS

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It provides a resource of cancer mechanisms under selection for somatic mutations and captures novel protein assemblies on which mutations unexpectedly converge.</p> <span class='read'><a class="read-mobile hvr-icon-float-away" href="http://ccmi.org/nest">Read more</a></span> </div> </div> <div class="clearfix"></div> </div> <script> $('#nogaputuxfrciwsmquss').dynamicMaxHeight(); </script> </div> </div><div class="row"> <div class="col-xs-12 col-sm-12 col-md-12 header_position" >  <div class="column skyblue-light" > <div class="col-md-8 no-padding"> <div class="con-img image-fit-class medium-block-strict" style="overflow: hidden"> <div class="overlay"></div> <img src="https://www.ccmi.org/site-assets/images/1712857889_DDRAM Fig 4 G.png" alt="" class="img-responsive formation-img-tablet" /> </div> </div> <div class="col-md-4 medium-block no-padding " data-maxheight="90" id="krrjyvivjndxbkyreslc"> <div class="con-txt formation-txt no-fade-txt text3-link-control medium-block" > <h2>DDRAm</h2> <p>The DNA damage response (DDR) ensures error-free DNA replication and transcription and is disrupted in numerous diseases. An ongoing challenge is to determine the proteins orchestrating DDR and their organization into complexes, including constitutive interactions and those induced by genomic insults. </p> <span class='read'><a class="read-mobile hvr-icon-float-away" href="https://ccmi.org/ddram/">Read more</a></span> </div> </div> <div class="clearfix"></div> </div> <script> $('#krrjyvivjndxbkyreslc').dynamicMaxHeight(); </script> </div> </div><div class="row"> <div class="col-xs-12 col-sm-12 col-md-12 header_position" >   <div class="column"> <div class="recent con-txt no-fade-txt oceanblue-light small-block" > <h2>A <span style="text-transform:lowercase; font-size:27px;">protein interaction landscape of breast cancer</span></h2> <p>Affinity purification combined with mass spectrometry (AP-MS) is used to catalog protein-protein interactions (PPIs) for 40 proteins significantly altered in breast cancer, including multidimensional measurements across mutant and normal protein isoforms and across cancerous and noncancerous cellular contexts.</p> </div> </div> </div> </div><div class="row"> <div class="col-xs-12 col-sm-12 col-md-12 header_position" >  <div class="column oceanblue-dark" > <div class="col-md-8 no-padding col-md-push-4"> <div class="con-img image-fit-class tech-image medium-block-strict" style="overflow: hidden"> <div class="overlay"></div> <img src="http://ccmi.org/site-assets/images/1636142728_swaney.png" alt="" class="img-responsive formation-img-tablet" /> </div> </div> <div class="col-md-4 no-padding medium-block col-md-pull-8" data-maxheight="90" id="iadkkbbptmsspxypvrfo"> <div class="con-txt formation-txt no-fade-txt text3-link-control medium-block" > <h2>A <span style="text-transform:lowercase; font-size:27px;">protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity</span></h2> <p>This map uncovers 771 interactions from cancer and noncancerous cell states, including WT and mutant protein isoforms and enhances our understanding of head and neck squamous cell carcinoma.</p> <span class='read'><a class="read-mobile hvr-icon-float-away" href="https://www.ndexbio.org/#/networkset/54a67f8e-e8e3-11eb-b666-0ac135e8bacf">Read more</a></span> </div> </div> <div class="clearfix"></div> </div> <script> $('#iadkkbbptmsspxypvrfo').dynamicMaxHeight(); </script> </div> </div><div class="row"> <div class="col-xs-12 col-sm-12 col-md-12 header_position" >  <div class="column oceanblue-light" > <div class="col-md-8 no-padding"> <div class="con-img image-fit-class medium-block-strict" style="overflow: hidden"> <div class="overlay"></div> <img src="https://www.ccmi.org/site-assets/images/1712858467_20220509 MuSIC_BuildingCellStructure_puzzle (gray).png" alt="" class="img-responsive formation-img-tablet" /> </div> </div> <div class="col-md-4 medium-block no-padding " data-maxheight="90" id="dorfodgkydqhetrovtep"> <div class="con-txt formation-txt no-fade-txt text3-link-control medium-block" > <h2>MuSIC </h2> <p>Multi-Scale Integrated Cell (MuSIC) is a hierarchical map of the eukaryotic cell architecture created from integrating immunofluorescence images in the Human Protein Atlas with affinity purification experiments from the BioPlex resource.</p> <span class='read'><a class="read-mobile hvr-icon-float-away" href="https://musicmaps.ai/">Read more</a></span> </div> </div> <div class="clearfix"></div> </div> <script> $('#dorfodgkydqhetrovtep').dynamicMaxHeight(); </script> </div> </div><div class="row"> <div class="col-xs-12 col-sm-12 col-md-12 header_position" >  <div class="column denimblue-medium" > <div class="col-md-8 no-padding col-md-push-4"> <div class="con-img image-fit-class tech-image medium-block-strict" style="overflow: hidden"> <div class="overlay"></div> <img src="http://ccmi.org/site-assets/images/1635988744_drugcell.png" alt="" class="img-responsive formation-img-tablet" /> </div> </div> <div class="col-md-4 no-padding medium-block col-md-pull-8" data-maxheight="90" id="gwhvuglpyqdbfvhuyoex"> <div class="con-txt formation-txt no-fade-txt text3-link-control medium-block" > <h2>D<span style="text-transform:lowercase; font-size:27px;">rugcell</span> O<span style="text-transform:lowercase; font-size:27px;">racle</span></h2> <p>DrugCell is a “visible” neural network (VNN) that predicts anti-cancer drug responses by modeling the hierarchical organization of a human cancer cell. Genotypes and drug structures induce differential patterns of activity on cellular subsystems, enabling in silico investigations of the molecular mechanisms underlying cancer drug response.</p> <span class='read'><a class="read-mobile hvr-icon-float-away" href="http://drugcell.ucsd.edu/landing/">Read more</a></span> </div> </div> <div class="clearfix"></div> </div> <script> $('#gwhvuglpyqdbfvhuyoex').dynamicMaxHeight(); </script> </div> </div><div class="row"> <div class="col-xs-12 col-sm-12 col-md-12 header_position" >  <div class="column skyblue-light" > <div class="col-md-8 no-padding"> <div class="con-img image-fit-class medium-block-strict" style="overflow: hidden"> <div class="overlay"></div> <img src="https://www.ccmi.org/site-assets/images/1712858761_DCELL.png" alt="" class="img-responsive formation-img-tablet" /> </div> </div> <div class="col-md-4 medium-block no-padding " data-maxheight="90" id="svewpwlkqpzwmgsgndvl"> <div class="con-txt formation-txt no-fade-txt text3-link-control medium-block" > <h2>DCell 1.4</h2> <p>DCell is a deep neural network model of budding yeast, a basic eukaryotic cell. The model structure corresponds exactly to a hierarchy of 2,526 cellular subsystems. Given this neural network structure, DCell has been trained to translate genotype to phenotype.</p> <span class='read'><a class="read-mobile hvr-icon-float-away" href="http://dcell.ucsd.edu/">Read more</a></span> </div> </div> <div class="clearfix"></div> </div> <script> $('#svewpwlkqpzwmgsgndvl').dynamicMaxHeight(); </script> </div> </div><div class="row"> <div class="col-xs-12 col-sm-12 col-md-4 padding-right-ten">  <div class="column"> <div class="recentft con-txt recent no-float no-fade-txt recent-with-link oceanblue-dark medium-block"> <h2>View all cell maps</h2> <p>All cell maps generated by the CCMI will be distributed via the Network Data Exchange (NDEx) Project.<br><br>To learn more about NDEx, please visit the <a href="../technology" target="_blank"><b>Technology</b></a> page.</p> <span class="read"> <a href="https://www.ndexbio.org/#/user/b47268a6-8112-11e6-b0a6-06603eb7f303" target="blank" class="hvr-icon-float-away">Read More</a> </span> </div> </div> </div> <div class="col-xs-12 col-sm-12 col-md-8 padding-left-ten"> <div class="column"> <div class="recentbox medium-block column hover transition oceanblue-light"> <div class="col-xs-12 col-sm-12 col-md-6 no-padding col-md-push-6"> <div class="recentrt medium-block fix-height-mob"> <div class="overlay"></div> <img src="http://ccmi.org/site-assets/images/1493314879_Screen Shot 2017-04-27 at 10.40.43 AM.png" alt="" class="img-responsive press-tablet-img" /> </div> </div> <div class="col-xs-12 col-sm-12 col-md-6 no-padding col-md-pull-6"> <div class="recentft medium-block press-tablet press-mobile"> <h2>FAQ: Networks, Cell Maps and NDE<span style="text-transform:lowercase; font-size:27px;">x</span></h2> <span class="date"> </span> <h4><a href="/cell-maps-faq"><span style="font-size:15px;">A reference guide for CCMI investigators on using NDEx to store, share, and publish cell maps. </a></h4> <span class="read"><a href="/cell-maps-faq" class="hvr-icon-float-away">Read More</a></span> </div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="clearfix"></div> </div>  </div> </section> <footer> <div class="container"> <div class="row footer-logo"> <ul><div class="col-xs-12 col-sm-4 col-md-4"> <a href="https://www.cancer.gov/" target="_blank"> <img src="http://www.ccmi.org/site-assets/images/1494630650_nci_grey50-01.png" class="img-responsive"> </a> </div><div class="col-xs-12 col-sm-4 col-md-4"> <a href="https://ucsd.edu/" target="_blank"> <img src="http://www.ccmi.org/site-assets/images/1492256048_footer-logo2.png" class="img-responsive"> </a> </div><div class="col-xs-12 col-sm-4 col-md-4"> <a href="https://www.ucsf.edu/" target="_blank"> <img src="http://www.ccmi.org/site-assets/images/1492256083_footer-logo4.png" class="img-responsive"> </a> </div><div class="col-xs-12 col-sm-4 col-md-4"> <a href="https://cancer.ucsf.edu/" target="_blank"> <img src="http://www.ccmi.org/site-assets/images/1492256091_footer-logo5.png" class="img-responsive"> </a> </div><div class="col-xs-12 col-sm-4 col-md-4"> <a href="https://today.ucsd.edu/story/uc_san_diego_raises_177.5_million_to_break_campus_fundraising_record" target="_blank"> <img src="http://www.ccmi.org/site-assets/images/1492256098_footer-logo6.png" class="img-responsive"> </a> </div><div class="col-xs-12 col-sm-4 col-md-4"> <a href="https://roddenberryprize.org/" target="_blank"> <img src="http://www.ccmi.org/site-assets/images/1494629940_roddenberry-foundation_grey50-01.jpg" class="img-responsive"> </a> </div></ul> </div> <div class="row foooter-address-bar"> <div class="col-xs-12 col-sm-12 col-md-4 col-lg-5"> <i class="fa fa-map-marker footer-map-icon" aria-hidden="true"></i> <p> <a href="https://ccmi.org/about" target="_blank"> Contact Us </a> </p> </div> <div class="col-xs-12 col-sm-12 col-md-3 col-lg-2 padding-right"> <p> <i class="fa fa-envelope footer-envelope-icon" aria-hidden="true"></i> <a href="mailto:hello@ccmi.org"> hello@ccmi.org </a> </p> </div> <div class="col-xs-12 col-sm-12 col-md-3 col-lg-2 col-lg-offset-1">     </div> <div class="col-xs-12 col-sm-12 col-md-2 col-lg-2 footer-social-icon"> <ul> <li><a target="_blank" href="https://twitter.com/CancerCellMap"><i class="fa fa-twitter twitter" aria-hidden="true"></i></a></li> <li><a target="_blank" href="https://www.youtube.com/@ccmiadmin9648"><i class="fa fa-youtube youtube" aria-hidden="true"></i></a></li> </ul> </div> </div> <div class="row footer-links" id="footer-toggle" style="display: block;"> <div class="col-md-12"> <h2></h2> </div> <div class="col-xs-12 col-md-12"> <ul id="main-navbar"></ul> </div> </div> </div> </footer> <div class="footer-close-panel" id="footer-close-panel"> <div class="container"> <div class="row"> <div class="col-xs-12 col-sm-5 col-md-4 padding-right ">  <p>©2017 The Regents of the University of California</p> </div> <div class="col-xs-12 col-sm-2 col-sm-offset-1 col-md-1 col-md-offset-2 more-button no-padding"> <div class="mobile-more-btn" style="display: none"> <p> <a id="menu-open-close"><span id="spantext">More</span> <img src="images/scroll-down.png" class="img-responsive footer-more"></a> </p> </div> </div> <div class="col-xs-12 col-sm-3 col-md-3 col-md-offset-2 text-right pull-right"> <p>Site design by <span><a href="http://www.goodvsevil.co" target="_blank">Good vs Evil</a></span></p> </div> </div> </div> </div> <script type='text/javascript' src='scripts/footer.js'></script> </body> </html>

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