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class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2015, Molecular BioSystems</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">37 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 110296449; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=110296449"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load 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ds-work-card--detail ds2-5-body-md">Akin to biological networks, prebiotic chemical networks can evolve and we have identified six key parameters that govern their evolution.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":108157744,"attachmentType":"pdf","workUrl":"https://www.academia.edu/110296449/Prebiotic_network_evolution_six_key_parameters"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":108157744,"attachmentType":"pdf","workUrl":"https://www.academia.edu/110296449/Prebiotic_network_evolution_six_key_parameters"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" 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In this paper we review the properties of these simple replicating networks, and show, via four working models, how even though closed systems exhibit a wide range of emergent phenomena, many of the more interesting phenomena leading to complexification and emergence indeed require open systems.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Open Prebiotic Environments Drive Emergent Phenomena and Complex Behavior","attachmentId":66545523,"attachmentType":"pdf","work_url":"https://www.academia.edu/47468372/Open_Prebiotic_Environments_Drive_Emergent_Phenomena_and_Complex_Behavior","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/47468372/Open_Prebiotic_Environments_Drive_Emergent_Phenomena_and_Complex_Behavior"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="71401853" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/71401853/An_ecological_framework_for_the_analysis_of_prebiotic_chemical_reaction_networks_and_their_dynamical_behavior">An ecological framework for the analysis of prebiotic chemical reaction networks and their dynamical behavior</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="22762584" href="https://independent.academia.edu/PlumAlex">Alex Plum</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2020</p><p class="ds-related-work--abstract ds2-5-body-sm">It is becoming widely accepted that very early in the origin of life, even before the emergence of genetic encoding, reaction networks of diverse small chemicals might have manifested key properties of life, namely self-propagation and adaptive evolution. To explore this possibility, we formalize the dynamics of chemical reaction networks within the framework of chemical ecosystem ecology. To capture the idea that life-like chemical systems are maintained out of equilibrium by fluxes of energy-rich food chemicals, we model chemical ecosystems in well-mixed containers that are subject to constant dilution by a solution with a fixed concentration of food chemicals. Modelling all chemical reactions as fully reversible, we show that seeding an autocatalytic cycle (AC) with tiny amounts of one or more of its member chemicals results in logistic growth of all member chemicals in the cycle. This finding justifies drawing an instructive analogy between an AC and the population of a biologic...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"An ecological framework for the analysis of prebiotic chemical reaction networks and their dynamical behavior","attachmentId":80760012,"attachmentType":"pdf","work_url":"https://www.academia.edu/71401853/An_ecological_framework_for_the_analysis_of_prebiotic_chemical_reaction_networks_and_their_dynamical_behavior","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/71401853/An_ecological_framework_for_the_analysis_of_prebiotic_chemical_reaction_networks_and_their_dynamical_behavior"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="60814314" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/60814314/Autocatalytic_chemical_networks_preceded_proteins_and_RNA_in_evolution">Autocatalytic chemical networks preceded proteins and RNA in evolution</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="195681288" href="https://independent.academia.edu/JoanaCXavier">Joana C . Xavier</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Modern cells embody metabolic networks containing thousands of elements and form autocatalytic molecule sets that produce copies of themselves. How the first self-sustaining metabolic networks arose at life&#39;s origin is a major open question. Autocatalytic molecule sets smaller than metabolic networks were proposed as transitory intermediates at the origin of life, but evidence for their role in prebiotic evolution is lacking. Here we identify reflexively autocatalytic food-generated networks (RAFs) - self-sustaining networks that collectively catalyze all their reactions - embedded within microbial metabolism. RAFs in the metabolism of ancient anaerobic autotrophs that live from H2 and CO2 generate amino acids and bases, the monomeric components of protein and RNA, and acetyl-CoA, but amino acids and bases do not generate metabolic RAFs, indicating that small-molecule catalysis preceded polymers in biochemical evolution. RAFs uncover intermediate stages in the origin of metaboli...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Autocatalytic chemical networks preceded proteins and RNA in evolution","attachmentId":74091460,"attachmentType":"pdf","work_url":"https://www.academia.edu/60814314/Autocatalytic_chemical_networks_preceded_proteins_and_RNA_in_evolution","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/60814314/Autocatalytic_chemical_networks_preceded_proteins_and_RNA_in_evolution"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":108157744,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":108157744,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_108157744" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="3753686" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/3753686/Experimental_evolution_of_protein_protein_interaction_networks">Experimental evolution of protein-protein interaction networks</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="81706" href="https://harvard.academia.edu/BetulKacar">Betul Kacar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Betul Kacar and Eric Gaucher, 2013</p><div class="ds-related-work--ctas"><button 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translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/50724538/Unifying_Theories_of_Molecular_Community_and_Network_Evolution"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="13958845" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13958845/The_Evolution_of_Connectivity_in_Metabolic_Networks">The Evolution of Connectivity in Metabolic Networks</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33009664" 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modular scale-free network behavior","attachmentId":93317750,"attachmentType":"pdf","work_url":"https://www.academia.edu/89528108/The_early_history_and_emergence_of_molecular_functions_and_modular_scale_free_network_behavior","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/89528108/The_early_history_and_emergence_of_molecular_functions_and_modular_scale_free_network_behavior"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="1166887" data-sort-order="default"><a class="ds-related-work--title 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class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/1166887/Modular_co_evolution_of_metabolic_networks"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="104425380" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/104425380/Trajectory_dependent_Compositional_Outcomes_in_a_Prebiotic_Reaction_Network">Trajectory-dependent Compositional Outcomes in a Prebiotic Reaction Network</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="81355634" href="https://radboud.academia.edu/PeervanDuppen">Peer van Duppen</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Trajectory-dependent Compositional Outcomes in a Prebiotic Reaction Network","attachmentId":104159266,"attachmentType":"pdf","work_url":"https://www.academia.edu/104425380/Trajectory_dependent_Compositional_Outcomes_in_a_Prebiotic_Reaction_Network","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/104425380/Trajectory_dependent_Compositional_Outcomes_in_a_Prebiotic_Reaction_Network"><span class="ds2-5-text-link__content">View PDF</span><span 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class="ds-related-work--metadata ds2-5-body-xs">2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Network evolution: exploring the change and adaptation of complex ecological systems over deep time","attachmentId":92819420,"attachmentType":"pdf","work_url":"https://www.academia.edu/88931442/Network_evolution_exploring_the_change_and_adaptation_of_complex_ecological_systems_over_deep_time","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/88931442/Network_evolution_exploring_the_change_and_adaptation_of_complex_ecological_systems_over_deep_time"><span 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href="https://www.academia.edu/24813429/On_the_structure_and_evolution_of_protein_interaction_networks">On the structure and evolution of protein interaction networks</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47488207" href="https://santafe.academia.edu/JoshuaGrochow">Joshua A Grochow</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"On the structure and evolution of protein interaction networks","attachmentId":45140135,"attachmentType":"pdf","work_url":"https://www.academia.edu/24813429/On_the_structure_and_evolution_of_protein_interaction_networks","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a 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