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The aim of the trial was to improve remission... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20080336" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">One hundred seventy adult patients with acute lymphoblastic leukemia (ALL) or acute undifferentiated leukemia (AUL) were entered into a prospective multicenter therapy trial at 25 hospitals. The aim of the trial was to improve remission duration by using a modified form of an intensified induction regimen that was successful in childhood ALL, to define immunologic subtypes of ALL by use of cell-surface markers, and to extract other possible prognostic factors. The overall complete remission rate was 77.8%. The median overall survival time was 26 months, being 4 months for nonresponders and 32 months for responders. The median remission duration for the 126 patients with complete remission was 20 months. Prognostically favorable factors for remission duration were response to chemotherapy within 4 weeks, age less than 35 years, a low initial leukocyte count, and the immunologic subtypes c-ALL with early response to therapy and T-ALL, where 61% and 58%, respectively, are still in comp...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20080336" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6b080b39ffac4512bd5f710f4e360a96" rel="nofollow" data-download="{"attachment_id":41249728,"asset_id":20080336,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41249728/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41080518" href="https://uthsc.academia.edu/ArthurNienhuis">Arthur Nienhuis</a><script data-card-contents-for-user="41080518" type="text/json">{"id":41080518,"first_name":"Arthur","last_name":"Nienhuis","domain_name":"uthsc","page_name":"ArthurNienhuis","display_name":"Arthur Nienhuis","profile_url":"https://uthsc.academia.edu/ArthurNienhuis?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20080336 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20080336"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20080336, container: ".js-paper-rank-work_20080336", }); 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Prognostically favorable factors for remission duration were response to chemotherapy within 4 weeks, age less than 35 years, a low initial leukocyte count, and the immunologic subtypes c-ALL with early response to therapy and T-ALL, where 61% and 58%, respectively, are still in comp...","downloadable_attachments":[{"id":41249728,"asset_id":20080336,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41080518,"first_name":"Arthur","last_name":"Nienhuis","domain_name":"uthsc","page_name":"ArthurNienhuis","display_name":"Arthur Nienhuis","profile_url":"https://uthsc.academia.edu/ArthurNienhuis?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":14109,"name":"Leukemia","url":"https://www.academia.edu/Documents/in/Leukemia?f_ri=100732","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=100732","nofollow":false},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732"},{"id":280237,"name":"T lymphocytes","url":"https://www.academia.edu/Documents/in/T_lymphocytes?f_ri=100732"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=100732"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=100732"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes?f_ri=100732"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20324478" data-work_id="20324478" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20324478/Dielectric_properties_of_blood_an_investigation_of_haematocrit_dependence">Dielectric properties of blood: an investigation of haematocrit dependence</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20324478" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="36ccf14821c1d247fd3b1037b3c4151f" rel="nofollow" data-download="{"attachment_id":41285159,"asset_id":20324478,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41285159/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41607379" href="https://independent.academia.edu/ARouane">A. 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All rat IgM and IgG antibodies of this specificity are lytic with human complement, but only IgG2b is active in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_51674755" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The CAMPATH-1 family of antibodies recognize an abundant glycoprotein expressed on virtually all human lymphocytes. All rat IgM and IgG antibodies of this specificity are lytic with human complement, but only IgG2b is active in antibody-dependent cell-mediated cytotoxicity (ADCC). We compared the ability of IgM, IgG2a, and IgG2b to deplete lymphocytes in vivo in two patients with prolymphocytic transformation of B-cell chronic lymphocytic leukemia (CLL). The IgM (CAMPATH-1M) produced transient depletion of blood lymphocytes with consumption of complement but had no effect on solid masses or bone marrow. Similar transient depletion of blood lymphocytes was noted with the IgG2a (YTH34.5). In contrast, the IgG2b (CAMPATH-1G) produced long-lasting depletion of lymphocytes from blood and marrow and improvement in splenomegaly but no detectable changes in complement levels. These differences probably reflect the importance of Fc receptor binding for effective clearance of target cells in ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/51674755" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="82df79a908bbe1c7f5b84b20fec05a95" rel="nofollow" data-download="{"attachment_id":69294621,"asset_id":51674755,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/69294621/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="55958776" href="https://independent.academia.edu/MartinDyer">Martin Dyer</a><script data-card-contents-for-user="55958776" type="text/json">{"id":55958776,"first_name":"Martin","last_name":"Dyer","domain_name":"independent","page_name":"MartinDyer","display_name":"Martin Dyer","profile_url":"https://independent.academia.edu/MartinDyer?f_ri=100732","photo":"https://0.academia-photos.com/55958776/20163095/19903372/s65_martin.dyer.jpg"}</script></span></span></li><li class="js-paper-rank-work_51674755 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="51674755"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 51674755, container: ".js-paper-rank-work_51674755", }); 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All rat IgM and IgG antibodies of this specificity are lytic with human complement, but only IgG2b is active in antibody-dependent cell-mediated cytotoxicity (ADCC). We compared the ability of IgM, IgG2a, and IgG2b to deplete lymphocytes in vivo in two patients with prolymphocytic transformation of B-cell chronic lymphocytic leukemia (CLL). The IgM (CAMPATH-1M) produced transient depletion of blood lymphocytes with consumption of complement but had no effect on solid masses or bone marrow. Similar transient depletion of blood lymphocytes was noted with the IgG2a (YTH34.5). In contrast, the IgG2b (CAMPATH-1G) produced long-lasting depletion of lymphocytes from blood and marrow and improvement in splenomegaly but no detectable changes in complement levels. 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href="https://www.academia.edu/Documents/in/Atherosclerosis">Atherosclerosis</a>, <script data-card-contents-for-ri="8015" type="text/json">{"id":8015,"name":"Atherosclerosis","url":"https://www.academia.edu/Documents/in/Atherosclerosis?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="16664" href="https://www.academia.edu/Documents/in/Risk_assessment">Risk assessment</a>, <script data-card-contents-for-ri="16664" type="text/json">{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="80043" href="https://www.academia.edu/Documents/in/von_Willebrand_factor">von Willebrand factor</a><script data-card-contents-for-ri="80043" type="text/json">{"id":80043,"name":"von Willebrand factor","url":"https://www.academia.edu/Documents/in/von_Willebrand_factor?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23480951]'), work: {"id":23480951,"title":"Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC 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assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=100732","nofollow":false},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=100732","nofollow":false},{"id":80043,"name":"von Willebrand factor","url":"https://www.academia.edu/Documents/in/von_Willebrand_factor?f_ri=100732","nofollow":false},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=100732"},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=100732"},{"id":233800,"name":"African Americans","url":"https://www.academia.edu/Documents/in/African_Americans?f_ri=100732"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732"},{"id":283547,"name":"Introns","url":"https://www.academia.edu/Documents/in/Introns?f_ri=100732"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype?f_ri=100732"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=100732"},{"id":489736,"name":"Linkage Disequilibrium","url":"https://www.academia.edu/Documents/in/Linkage_Disequilibrium?f_ri=100732"},{"id":561981,"name":"European Continental Ancestry Group","url":"https://www.academia.edu/Documents/in/European_Continental_Ancestry_Group?f_ri=100732"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=100732"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=100732"},{"id":764111,"name":"factor VIII","url":"https://www.academia.edu/Documents/in/factor_VIII?f_ri=100732"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22016646" data-work_id="22016646" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22016646/CD4_T_lymphocytes_mediate_in_vivo_clearance_of_plasmid_DNA_vaccine_antigen_expression_and_potentiate_CD8_T_cell_immune_responses">CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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href="https://www.academia.edu/Documents/in/Immune_response">Immune response</a>, <script data-card-contents-for-ri="2702" type="text/json">{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="84760" href="https://www.academia.edu/Documents/in/Mice">Mice</a>, <script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="100732" href="https://www.academia.edu/Documents/in/Blood">Blood</a>, <script data-card-contents-for-ri="100732" type="text/json">{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="166422" href="https://www.academia.edu/Documents/in/DNA_vaccines">DNA vaccines</a><script data-card-contents-for-ri="166422" type="text/json">{"id":166422,"name":"DNA vaccines","url":"https://www.academia.edu/Documents/in/DNA_vaccines?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22016646]'), work: {"id":22016646,"title":"CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses","created_at":"2016-02-15T13:43:31.134-08:00","url":"https://www.academia.edu/22016646/CD4_T_lymphocytes_mediate_in_vivo_clearance_of_plasmid_DNA_vaccine_antigen_expression_and_potentiate_CD8_T_cell_immune_responses?f_ri=100732","dom_id":"work_22016646","summary":null,"downloadable_attachments":[{"id":42712556,"asset_id":22016646,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35244614,"first_name":"Nico Van","last_name":"Rooijen","domain_name":"independent","page_name":"NicoVanRooijen","display_name":"Nico Van Rooijen","profile_url":"https://independent.academia.edu/NicoVanRooijen?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=100732","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false},{"id":166422,"name":"DNA vaccines","url":"https://www.academia.edu/Documents/in/DNA_vaccines?f_ri=100732","nofollow":false},{"id":190363,"name":"Plasmids","url":"https://www.academia.edu/Documents/in/Plasmids?f_ri=100732"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732"},{"id":435727,"name":"Major histocompatibility complex","url":"https://www.academia.edu/Documents/in/Major_histocompatibility_complex?f_ri=100732"},{"id":1274458,"name":"Antigens","url":"https://www.academia.edu/Documents/in/Antigens?f_ri=100732"},{"id":1274831,"name":"NK Cell","url":"https://www.academia.edu/Documents/in/NK_Cell?f_ri=100732"},{"id":1320136,"name":"Plasmid DNA","url":"https://www.academia.edu/Documents/in/Plasmid_DNA?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21692935" data-work_id="21692935" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21692935/The_effects_of_blood_and_fat_on_Morse_taper_disassembly_forces">The effects of blood and fat on Morse taper disassembly forces</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Biological debris between modular components using Morse tapers in hip arthroplasty can lead to weakening of the implant construct. We conducted a study to determine the effect of blood and fat within the taper interface. Tapers were... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21692935" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Biological debris between modular components using Morse tapers in hip arthroplasty can lead to weakening of the implant construct. We conducted a study to determine the effect of blood and fat within the taper interface. Tapers were divided into groups 1 (clean), 2 (surface covered with blood and fat), and 3 (blood and fat wiped off). Each taper was impacted and disassembled 5 times. There was a difference in mean disassembly force between pulls within group 2. Thus, blood and fat contamination can have a significant effect on the potential for disassembly.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21692935" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f88a87cf7ddc5e8b1e0517342fa291e6" rel="nofollow" data-download="{"attachment_id":42389594,"asset_id":21692935,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42389594/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42862734" href="https://independent.academia.edu/LuisBaerga">Luis Baerga</a><script data-card-contents-for-user="42862734" type="text/json">{"id":42862734,"first_name":"Luis","last_name":"Baerga","domain_name":"independent","page_name":"LuisBaerga","display_name":"Luis Baerga","profile_url":"https://independent.academia.edu/LuisBaerga?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21692935 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21692935"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21692935, container: ".js-paper-rank-work_21692935", }); 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$(".js-view-count[data-work-id=21692935]").text(description); $(".js-view-count-work_21692935").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21692935").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21692935"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="11404" href="https://www.academia.edu/Documents/in/Titanium">Titanium</a>, <script data-card-contents-for-ri="11404" type="text/json">{"id":11404,"name":"Titanium","url":"https://www.academia.edu/Documents/in/Titanium?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="52489" href="https://www.academia.edu/Documents/in/Adipose_tissue">Adipose tissue</a>, <script data-card-contents-for-ri="52489" type="text/json">{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="100732" href="https://www.academia.edu/Documents/in/Blood">Blood</a>, <script data-card-contents-for-ri="100732" type="text/json">{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="715808" href="https://www.academia.edu/Documents/in/prosthesis_Design">prosthesis Design</a><script data-card-contents-for-ri="715808" type="text/json">{"id":715808,"name":"prosthesis Design","url":"https://www.academia.edu/Documents/in/prosthesis_Design?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21692935]'), work: {"id":21692935,"title":"The effects of blood and fat on Morse taper disassembly forces","created_at":"2016-02-08T08:08:13.851-08:00","url":"https://www.academia.edu/21692935/The_effects_of_blood_and_fat_on_Morse_taper_disassembly_forces?f_ri=100732","dom_id":"work_21692935","summary":"Biological debris between modular components using Morse tapers in hip arthroplasty can lead to weakening of the implant construct. We conducted a study to determine the effect of blood and fat within the taper interface. Tapers were divided into groups 1 (clean), 2 (surface covered with blood and fat), and 3 (blood and fat wiped off). Each taper was impacted and disassembled 5 times. There was a difference in mean disassembly force between pulls within group 2. Thus, blood and fat contamination can have a significant effect on the potential for disassembly.","downloadable_attachments":[{"id":42389594,"asset_id":21692935,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42862734,"first_name":"Luis","last_name":"Baerga","domain_name":"independent","page_name":"LuisBaerga","display_name":"Luis Baerga","profile_url":"https://independent.academia.edu/LuisBaerga?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":11404,"name":"Titanium","url":"https://www.academia.edu/Documents/in/Titanium?f_ri=100732","nofollow":false},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false},{"id":715808,"name":"prosthesis Design","url":"https://www.academia.edu/Documents/in/prosthesis_Design?f_ri=100732","nofollow":false},{"id":892969,"name":"Materials Testing","url":"https://www.academia.edu/Documents/in/Materials_Testing?f_ri=100732"},{"id":1157424,"name":"Equipment Failure Analysis","url":"https://www.academia.edu/Documents/in/Equipment_Failure_Analysis?f_ri=100732"},{"id":1863718,"name":"The American","url":"https://www.academia.edu/Documents/in/The_American?f_ri=100732"},{"id":1902100,"name":"Biomechanical Phenomena","url":"https://www.academia.edu/Documents/in/Biomechanical_Phenomena?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61202264" data-work_id="61202264" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61202264/Occupational_blood_exposure_among_unlicensed_home_care_workers_and_home_care_registered_nurses_Are_they_protected">Occupational blood exposure among unlicensed home care workers and home care registered nurses: Are they protected?</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61202264" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="55a121bcfbc63f20f51b76994bda389b" rel="nofollow" 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type="text/json">{"id":140117864,"first_name":"Jane","last_name":"Lipscomb","domain_name":"independent","page_name":"LipscombJane","display_name":"Jane Lipscomb","profile_url":"https://independent.academia.edu/LipscombJane?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61202264 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61202264"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61202264, container: ".js-paper-rank-work_61202264", }); });</script></li><li class="js-percentile-work_61202264 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61202264; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_61202264"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_61202264 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="61202264"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61202264; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61202264]").text(description); $(".js-view-count-work_61202264").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61202264").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61202264"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="35777" href="https://www.academia.edu/Documents/in/Home_Care">Home Care</a>, <script data-card-contents-for-ri="35777" type="text/json">{"id":35777,"name":"Home Care","url":"https://www.academia.edu/Documents/in/Home_Care?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="98134" href="https://www.academia.edu/Documents/in/United_States">United States</a>, <script data-card-contents-for-ri="98134" type="text/json">{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="99651" href="https://www.academia.edu/Documents/in/Community_health_nursing">Community health nursing</a>, <script data-card-contents-for-ri="99651" type="text/json">{"id":99651,"name":"Community health nursing","url":"https://www.academia.edu/Documents/in/Community_health_nursing?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="100732" href="https://www.academia.edu/Documents/in/Blood">Blood</a><script data-card-contents-for-ri="100732" type="text/json">{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61202264]'), work: {"id":61202264,"title":"Occupational blood exposure among unlicensed home care workers and home care registered nurses: Are they protected?","created_at":"2021-11-07T07:59:14.981-08:00","url":"https://www.academia.edu/61202264/Occupational_blood_exposure_among_unlicensed_home_care_workers_and_home_care_registered_nurses_Are_they_protected?f_ri=100732","dom_id":"work_61202264","summary":null,"downloadable_attachments":[{"id":74318647,"asset_id":61202264,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":140117864,"first_name":"Jane","last_name":"Lipscomb","domain_name":"independent","page_name":"LipscombJane","display_name":"Jane Lipscomb","profile_url":"https://independent.academia.edu/LipscombJane?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":35777,"name":"Home Care","url":"https://www.academia.edu/Documents/in/Home_Care?f_ri=100732","nofollow":false},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=100732","nofollow":false},{"id":99651,"name":"Community health nursing","url":"https://www.academia.edu/Documents/in/Community_health_nursing?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false},{"id":158034,"name":"Registered Nurse","url":"https://www.academia.edu/Documents/in/Registered_Nurse?f_ri=100732"},{"id":172784,"name":"Workload","url":"https://www.academia.edu/Documents/in/Workload?f_ri=100732"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=100732"},{"id":289315,"name":"Safety Management","url":"https://www.academia.edu/Documents/in/Safety_Management?f_ri=100732"},{"id":396914,"name":"Occupational Exposure","url":"https://www.academia.edu/Documents/in/Occupational_Exposure?f_ri=100732"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=100732"},{"id":557260,"name":"Health surveys","url":"https://www.academia.edu/Documents/in/Health_surveys?f_ri=100732"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=100732"},{"id":1146508,"name":"Body Fluids","url":"https://www.academia.edu/Documents/in/Body_Fluids?f_ri=100732"},{"id":1364082,"name":"Home Health Aides","url":"https://www.academia.edu/Documents/in/Home_Health_Aides?f_ri=100732"},{"id":2545170,"name":"Blood Borne Pathogens","url":"https://www.academia.edu/Documents/in/Blood_Borne_Pathogens?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_76343661" data-work_id="76343661" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/76343661/Production_of_viable_cultures_of_Flavobacterium_psychrophilum_approach_and_control">Production of viable cultures of Flavobacterium psychrophilum: approach and control</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/76343661" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="89322f46ed1d8f31f5abc99aa6b1ec64" rel="nofollow" data-download="{"attachment_id":84080355,"asset_id":76343661,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/84080355/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="93687603" href="https://independent.academia.edu/ChristianMichel13">Christian Michel</a><script data-card-contents-for-user="93687603" type="text/json">{"id":93687603,"first_name":"Christian","last_name":"Michel","domain_name":"independent","page_name":"ChristianMichel13","display_name":"Christian Michel","profile_url":"https://independent.academia.edu/ChristianMichel13?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_76343661 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="76343661"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 76343661, container: ".js-paper-rank-work_76343661", }); });</script></li><li class="js-percentile-work_76343661 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 76343661; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_76343661"); 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class="u-positionAbsolute" data-has-card-for-ri-list="76343661"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="159" href="https://www.academia.edu/Documents/in/Microbiology">Microbiology</a>, <script data-card-contents-for-ri="159" type="text/json">{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6947" href="https://www.academia.edu/Documents/in/Medical_Microbiology">Medical Microbiology</a>, <script data-card-contents-for-ri="6947" type="text/json">{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="100732" href="https://www.academia.edu/Documents/in/Blood">Blood</a>, <script data-card-contents-for-ri="100732" type="text/json">{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="112325" href="https://www.academia.edu/Documents/in/Flavobacterium">Flavobacterium</a><script data-card-contents-for-ri="112325" type="text/json">{"id":112325,"name":"Flavobacterium","url":"https://www.academia.edu/Documents/in/Flavobacterium?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=76343661]'), work: {"id":76343661,"title":"Production of viable cultures of Flavobacterium psychrophilum: approach and 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72726018/Cycling_without_brakes_lets_ALL_escape">Cycling without brakes lets ALL escape</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72726018" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3515b277b2d021f7f7de0f2acb9d690f" rel="nofollow" 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window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_72726018"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_72726018 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="72726018"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72726018; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72726018]").text(description); $(".js-view-count-work_72726018").attr('title', description).tooltip(); }); });</script></span><script>$(function() { 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class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72211334/Recurrent_genetic_abnormalities_can_be_used_for_risk_group_stratification_in_pediatric_AMKL_results_of_a_retrospective_intergroup_study">Recurrent genetic abnormalities can be used for risk-group stratification in pediatric AMKL: results of a retrospective intergroup study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Genetic abnormalities and early treatment response are the main prognostic factors in acute myeloid leukemia (AML). Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. Deep sequencing has identified CBFA2T3/GLIS2 and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72211334" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Genetic abnormalities and early treatment response are the main prognostic factors in acute myeloid leukemia (AML). Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. Deep sequencing has identified CBFA2T3/GLIS2 and NUP98/KDM5A as recurrent aberrations, occurring in similar frequencies as RBM15/MKL1 and KMT2A-rearrangements. We studied whether these cytogenetic aberrations can be used for risk-group stratification. To assess frequencies and outcome parameters of recurrent cytogenetic aberrations in AMKL, samples and clinical data of patients treated by the AIEOP, BFM-SG, COG, DCOG and the Saint Louis Hopital were collected, enabling us to screen 153 newly diagnosed pediatric AMKL cases for the aforementioned aberrations, and to study their clinical characteristics and outcome. CBFA2T3/GLIS2 was identified in 16% of the cases, RBM15/MKL1 in 12%, NUP98/KDM5A and KMT2A-rearrangements in 9% each, and monosomy 7 was identified in 6%. These aberrations were mutually exclusiv...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72211334" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="13281928c72e749b359d42a6e8228cee" rel="nofollow" data-download="{"attachment_id":81229575,"asset_id":72211334,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81229575/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40666251" href="https://independent.academia.edu/MartinaPigazzi">Martina Pigazzi</a><script data-card-contents-for-user="40666251" type="text/json">{"id":40666251,"first_name":"Martina","last_name":"Pigazzi","domain_name":"independent","page_name":"MartinaPigazzi","display_name":"Martina Pigazzi","profile_url":"https://independent.academia.edu/MartinaPigazzi?f_ri=100732","photo":"https://0.academia-photos.com/40666251/13033671/14376859/s65_martina.pigazzi.jpg"}</script></span></span></li><li class="js-paper-rank-work_72211334 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72211334"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72211334, container: ".js-paper-rank-work_72211334", }); 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Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. Deep sequencing has identified CBFA2T3/GLIS2 and NUP98/KDM5A as recurrent aberrations, occurring in similar frequencies as RBM15/MKL1 and KMT2A-rearrangements. We studied whether these cytogenetic aberrations can be used for risk-group stratification. To assess frequencies and outcome parameters of recurrent cytogenetic aberrations in AMKL, samples and clinical data of patients treated by the AIEOP, BFM-SG, COG, DCOG and the Saint Louis Hopital were collected, enabling us to screen 153 newly diagnosed pediatric AMKL cases for the aforementioned aberrations, and to study their clinical characteristics and outcome. CBFA2T3/GLIS2 was identified in 16% of the cases, RBM15/MKL1 in 12%, NUP98/KDM5A and KMT2A-rearrangements in 9% each, and monosomy 7 was identified in 6%. These aberrations were mutually exclusiv...","downloadable_attachments":[{"id":81229575,"asset_id":72211334,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40666251,"first_name":"Martina","last_name":"Pigazzi","domain_name":"independent","page_name":"MartinaPigazzi","display_name":"Martina Pigazzi","profile_url":"https://independent.academia.edu/MartinaPigazzi?f_ri=100732","photo":"https://0.academia-photos.com/40666251/13033671/14376859/s65_martina.pigazzi.jpg"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=100732","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=100732","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=100732","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=100732"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=100732"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=100732"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=100732"},{"id":3677822,"name":"Chromosome aberrations","url":"https://www.academia.edu/Documents/in/Chromosome_aberrations?f_ri=100732"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=100732"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70464653" data-work_id="70464653" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70464653/ADAMTS13_autoantibodies_in_patients_with_thrombotic_microangiopathies_and_other_immunomediated_diseases">ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseases</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Autoantibodies neutralizing human ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif), the metalloprotease that physiologically cleaves von Willebrand factor, are a major cause of severe deficiency of the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70464653" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Autoantibodies neutralizing human ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif), the metalloprotease that physiologically cleaves von Willebrand factor, are a major cause of severe deficiency of the protease and of acquired thrombotic ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70464653" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7eac07e086ff124d7aa1e209f1a0fced" rel="nofollow" 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Erythematosus","url":"https://www.academia.edu/Documents/in/Systemic_Lupus_Erythematosus?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71304" href="https://www.academia.edu/Documents/in/Autoimmune_diseases">Autoimmune diseases</a>, <script data-card-contents-for-ri="71304" type="text/json">{"id":71304,"name":"Autoimmune diseases","url":"https://www.academia.edu/Documents/in/Autoimmune_diseases?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="80043" href="https://www.academia.edu/Documents/in/von_Willebrand_factor">von Willebrand factor</a><script data-card-contents-for-ri="80043" type="text/json">{"id":80043,"name":"von Willebrand factor","url":"https://www.academia.edu/Documents/in/von_Willebrand_factor?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=70464653]'), work: 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G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G?f_ri=100732"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=100732"},{"id":2538635,"name":"Antiphospholipid Syndrome","url":"https://www.academia.edu/Documents/in/Antiphospholipid_Syndrome?f_ri=100732"},{"id":2892963,"name":"immunoglobulin M","url":"https://www.academia.edu/Documents/in/immunoglobulin_M?f_ri=100732"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=100732"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70417849" data-work_id="70417849" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70417849/Cytokine_Gene_Expression_in_B_Cell_Chronic_Lymphocytic_Leukemia_Evidence_of_Constitutive_Interleukin_8_IL_8_mRNA_Expression_and_Secretion_of_Biologically_Active_IL_8_Protein">Cytokine Gene Expression in B-Cell Chronic Lymphocytic Leukemia: Evidence of Constitutive Interleukin-8 (IL-8) mRNA Expression and Secretion of Biologically Active IL-8 Protein</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To extend our knowledge on the cytokines possibly involved in the pathophysiology of B-cell chronic lymphocytic leukemia (B-CLL), the mRNA expression of a panel of 10 cytokines was investigated on purified B-CLL cells using a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70417849" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To extend our knowledge on the cytokines possibly involved in the pathophysiology of B-cell chronic lymphocytic leukemia (B-CLL), the mRNA expression of a panel of 10 cytokines was investigated on purified B-CLL cells using a reversetranscriptase polymerase chain reaction method. Whereas negative RT-PCR signals were recorded for interleukin-la</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70417849" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="36b4f09f42a229afc6d682a2abf31d18" rel="nofollow" data-download="{"attachment_id":80179542,"asset_id":70417849,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/80179542/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32627395" href="https://independent.academia.edu/SimonaZupo">Simona Zupo</a><script data-card-contents-for-user="32627395" type="text/json">{"id":32627395,"first_name":"Simona","last_name":"Zupo","domain_name":"independent","page_name":"SimonaZupo","display_name":"Simona Zupo","profile_url":"https://independent.academia.edu/SimonaZupo?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_70417849 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70417849"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70417849, container: ".js-paper-rank-work_70417849", }); 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$(".js-view-count[data-work-id=70417849]").text(description); $(".js-view-count-work_70417849").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_70417849").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="70417849"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9111" href="https://www.academia.edu/Documents/in/Cytokines">Cytokines</a>, <script data-card-contents-for-ri="9111" type="text/json">{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="27784" href="https://www.academia.edu/Documents/in/Gene_expression">Gene expression</a><script data-card-contents-for-ri="27784" type="text/json">{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=70417849]'), work: {"id":70417849,"title":"Cytokine Gene Expression in B-Cell Chronic Lymphocytic Leukemia: Evidence of Constitutive Interleukin-8 (IL-8) mRNA Expression and Secretion of Biologically Active IL-8 Protein","created_at":"2022-02-04T05:33:00.605-08:00","url":"https://www.academia.edu/70417849/Cytokine_Gene_Expression_in_B_Cell_Chronic_Lymphocytic_Leukemia_Evidence_of_Constitutive_Interleukin_8_IL_8_mRNA_Expression_and_Secretion_of_Biologically_Active_IL_8_Protein?f_ri=100732","dom_id":"work_70417849","summary":"To extend our knowledge on the cytokines possibly involved in the pathophysiology of B-cell chronic lymphocytic leukemia (B-CLL), the mRNA expression of a panel of 10 cytokines was investigated on purified B-CLL cells using a reversetranscriptase polymerase chain reaction method. Whereas negative RT-PCR signals were recorded for interleukin-la","downloadable_attachments":[{"id":80179542,"asset_id":70417849,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32627395,"first_name":"Simona","last_name":"Zupo","domain_name":"independent","page_name":"SimonaZupo","display_name":"Simona Zupo","profile_url":"https://independent.academia.edu/SimonaZupo?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=100732","nofollow":false},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=100732","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=100732","nofollow":false},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=100732","nofollow":false},{"id":82976,"name":"Chronic Lymphocytic Leukemia","url":"https://www.academia.edu/Documents/in/Chronic_Lymphocytic_Leukemia?f_ri=100732"},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction?f_ri=100732"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732"},{"id":310960,"name":"mRna expression levels","url":"https://www.academia.edu/Documents/in/mRna_expression_levels?f_ri=100732"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes?f_ri=100732"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity?f_ri=100732"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=100732"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=100732"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_64511340 coauthored" data-work_id="64511340" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/64511340/Apixaban_Treatment_Decreases_Coagulation_Activity_in_Patients_with_Acute_Deep_Vein_Thrombosis">Apixaban Treatment Decreases Coagulation Activity in Patients with Acute Deep-Vein Thrombosis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Elevated levels of coagulation markers such as D-dimer, prothrombin fragment 1+2 (F1+2), and thrombin antithrombin (TAT) have been associated with increased risk for thrombotic events. Apixaban, an oral, selective, direct... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_64511340" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Elevated levels of coagulation markers such as D-dimer, prothrombin fragment 1+2 (F1+2), and thrombin antithrombin (TAT) have been associated with increased risk for thrombotic events. Apixaban, an oral, selective, direct inhibitor of factor Xa, was shown to be effective for the prevention and treatment of venous thromboembolism (VTE). Apixaban is also in development for stroke prevention in atrial fibrillation patients and secondary prevention in patients with acutre coronary syndrome. This study was conducted to assess changes in coagulation biomarkers after apixaban treatment. Methods: Approximately 1430 plasma samples (pre-dose, week 3 and week 12) were obtained from 520 patients who participated in a phase 2, randomized, parallel-arm, double-blind study of apixaban for the treatment of acute symptomatic deep-vein thrombosis. The study comprised 4 dose arms of approximately 130 patients each (apixaban 5 mg bid, 10 mg bid, 20 mg qd, and 1 active control arm, low molec...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/64511340" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="160974423" href="https://independent.academia.edu/PuneetMohan3">Puneet Mohan</a><script data-card-contents-for-user="160974423" type="text/json">{"id":160974423,"first_name":"Puneet","last_name":"Mohan","domain_name":"independent","page_name":"PuneetMohan3","display_name":"Puneet Mohan","profile_url":"https://independent.academia.edu/PuneetMohan3?f_ri=100732","photo":"https://0.academia-photos.com/160974423/63785744/52097203/s65_puneet.mohan.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-64511340">+1</span><div class="hidden js-additional-users-64511340"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/RobertKnabb">Robert Knabb</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-64511340'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-64511340').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_64511340 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="64511340"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 64511340, container: ".js-paper-rank-work_64511340", }); });</script></li><li class="js-percentile-work_64511340 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64511340; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_64511340"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_64511340 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="64511340"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64511340; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64511340]").text(description); $(".js-view-count-work_64511340").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_64511340").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="64511340"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="100732" href="https://www.academia.edu/Documents/in/Blood">Blood</a>, <script data-card-contents-for-ri="100732" type="text/json">{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3789879" href="https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology">Cardiovascular medicine and haematology</a>, <script data-card-contents-for-ri="3789879" type="text/json">{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3789883" href="https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine">Paediatrics and reproductive medicine</a><script data-card-contents-for-ri="3789883" type="text/json">{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=64511340]'), work: {"id":64511340,"title":"Apixaban Treatment Decreases Coagulation Activity in Patients with Acute Deep-Vein Thrombosis","created_at":"2021-12-16T04:44:06.660-08:00","url":"https://www.academia.edu/64511340/Apixaban_Treatment_Decreases_Coagulation_Activity_in_Patients_with_Acute_Deep_Vein_Thrombosis?f_ri=100732","dom_id":"work_64511340","summary":"Background: Elevated levels of coagulation markers such as D-dimer, prothrombin fragment 1+2 (F1+2), and thrombin antithrombin (TAT) have been associated with increased risk for thrombotic events. Apixaban, an oral, selective, direct inhibitor of factor Xa, was shown to be effective for the prevention and treatment of venous thromboembolism (VTE). Apixaban is also in development for stroke prevention in atrial fibrillation patients and secondary prevention in patients with acutre coronary syndrome. This study was conducted to assess changes in coagulation biomarkers after apixaban treatment. Methods: Approximately 1430 plasma samples (pre-dose, week 3 and week 12) were obtained from 520 patients who participated in a phase 2, randomized, parallel-arm, double-blind study of apixaban for the treatment of acute symptomatic deep-vein thrombosis. The study comprised 4 dose arms of approximately 130 patients each (apixaban 5 mg bid, 10 mg bid, 20 mg qd, and 1 active control arm, low molec...","downloadable_attachments":[],"ordered_authors":[{"id":160974423,"first_name":"Puneet","last_name":"Mohan","domain_name":"independent","page_name":"PuneetMohan3","display_name":"Puneet Mohan","profile_url":"https://independent.academia.edu/PuneetMohan3?f_ri=100732","photo":"https://0.academia-photos.com/160974423/63785744/52097203/s65_puneet.mohan.png"},{"id":218291333,"first_name":"Robert","last_name":"Knabb","domain_name":"independent","page_name":"RobertKnabb","display_name":"Robert Knabb","profile_url":"https://independent.academia.edu/RobertKnabb?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732","nofollow":false},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=100732","nofollow":false},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=100732","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61916299" data-work_id="61916299" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61916299/Genomic_and_functional_integrity_of_the_hematopoietic_system_requires_tolerance_of_oxidative_DNA_lesions">Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Endogenous DNA damage is causally associated with the functional decline and transformation of stem cells that characterize ageing. DNA lesions that have escaped DNA repair can induce replication stress and genomic breaks that induce... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61916299" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Endogenous DNA damage is causally associated with the functional decline and transformation of stem cells that characterize ageing. DNA lesions that have escaped DNA repair can induce replication stress and genomic breaks that induce senescence and apoptosis. It is not clear how stem and proliferating cells cope with accumulating endogenous DNA lesions, and how these ultimately affect the physiology of cells and tissues. Here we have addressed these questions by investigating the hematopoietic system of mice deficient for Rev1, a core factor in DNA translesion synthesis (TLS), the post-replicative bypass of damaged nucleotides. Rev1 hematopoietic stem and progenitor cells displayed compromised proliferation, and replication stress that could be rescued with an antioxidant. The additional disruption of Xpc, essential for global-genome nucleotide excision repair (ggNER) of helix-distorting nucleotide lesions, resulted in the perinatal loss of hematopoietic stem cells, progressive loss...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61916299" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="918285b53590be87320f7832220167bf" rel="nofollow" data-download="{"attachment_id":74828131,"asset_id":61916299,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74828131/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45767226" href="https://independent.academia.edu/NielsWind">Niels Wind</a><script data-card-contents-for-user="45767226" type="text/json">{"id":45767226,"first_name":"Niels","last_name":"Wind","domain_name":"independent","page_name":"NielsWind","display_name":"Niels Wind","profile_url":"https://independent.academia.edu/NielsWind?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61916299 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61916299"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61916299, container: ".js-paper-rank-work_61916299", }); });</script></li><li class="js-percentile-work_61916299 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61916299; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_61916299"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_61916299 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="61916299"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61916299; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61916299]").text(description); $(".js-view-count-work_61916299").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61916299").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61916299"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="14292" href="https://www.academia.edu/Documents/in/Oxidative_Stress">Oxidative Stress</a>, <script data-card-contents-for-ri="14292" type="text/json">{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23066" href="https://www.academia.edu/Documents/in/DNA_damage">DNA damage</a>, <script data-card-contents-for-ri="23066" type="text/json">{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23067" href="https://www.academia.edu/Documents/in/DNA_repair">DNA repair</a>, <script data-card-contents-for-ri="23067" type="text/json">{"id":23067,"name":"DNA repair","url":"https://www.academia.edu/Documents/in/DNA_repair?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24731" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a><script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61916299]'), work: {"id":61916299,"title":"Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions","created_at":"2021-11-18T01:36:25.792-08:00","url":"https://www.academia.edu/61916299/Genomic_and_functional_integrity_of_the_hematopoietic_system_requires_tolerance_of_oxidative_DNA_lesions?f_ri=100732","dom_id":"work_61916299","summary":"Endogenous DNA damage is causally associated with the functional decline and transformation of stem cells that characterize ageing. DNA lesions that have escaped DNA repair can induce replication stress and genomic breaks that induce senescence and apoptosis. It is not clear how stem and proliferating cells cope with accumulating endogenous DNA lesions, and how these ultimately affect the physiology of cells and tissues. Here we have addressed these questions by investigating the hematopoietic system of mice deficient for Rev1, a core factor in DNA translesion synthesis (TLS), the post-replicative bypass of damaged nucleotides. Rev1 hematopoietic stem and progenitor cells displayed compromised proliferation, and replication stress that could be rescued with an antioxidant. The additional disruption of Xpc, essential for global-genome nucleotide excision repair (ggNER) of helix-distorting nucleotide lesions, resulted in the perinatal loss of hematopoietic stem cells, progressive loss...","downloadable_attachments":[{"id":74828131,"asset_id":61916299,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45767226,"first_name":"Niels","last_name":"Wind","domain_name":"independent","page_name":"NielsWind","display_name":"Niels Wind","profile_url":"https://independent.academia.edu/NielsWind?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=100732","nofollow":false},{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage?f_ri=100732","nofollow":false},{"id":23067,"name":"DNA repair","url":"https://www.academia.edu/Documents/in/DNA_repair?f_ri=100732","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=100732","nofollow":false},{"id":53113,"name":"Hematopoietic Stem Cells","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cells?f_ri=100732"},{"id":60567,"name":"Cellular Senescence","url":"https://www.academia.edu/Documents/in/Cellular_Senescence?f_ri=100732"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=100732"},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow?f_ri=100732"},{"id":176486,"name":"Genome","url":"https://www.academia.edu/Documents/in/Genome?f_ri=100732"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=100732"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=100732"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_34764691" data-work_id="34764691" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/34764691/Martyrs_Blood_in_the_English_Reformations">Martyrs' Blood in the English Reformations</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Protestant and Catholic martyrologies evolved in dialogue; however, they did not articulate a common conception of martyrdom. Viewing Protestant and Catholic martyrologies and notions of martyrdom as essentially similar obscures highly... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_34764691" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Protestant and Catholic martyrologies evolved in dialogue; however, they did not articulate a common conception of martyrdom. Viewing Protestant and Catholic martyrologies and notions of martyrdom as essentially similar obscures highly significant confessional differences, which generated fiercely opposed constructions of martyrdom. This argument is examined through an analysis of the treatment of martyrs’ blood in English martyrological texts, since this encapsulated core confessional theologies.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/34764691" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="435541a4a2ed9056c80422d65db54246" rel="nofollow" data-download="{"attachment_id":54623845,"asset_id":34764691,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54623845/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="30323831" href="https://cambridge.academia.edu/AnastasiaStylianou">Anastasia Stylianou</a><script data-card-contents-for-user="30323831" type="text/json">{"id":30323831,"first_name":"Anastasia","last_name":"Stylianou","domain_name":"cambridge","page_name":"AnastasiaStylianou","display_name":"Anastasia Stylianou","profile_url":"https://cambridge.academia.edu/AnastasiaStylianou?f_ri=100732","photo":"https://0.academia-photos.com/30323831/9860922/14303080/s65_anastasia.stylianou.jpg"}</script></span></span></li><li class="js-paper-rank-work_34764691 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="34764691"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 34764691, container: ".js-paper-rank-work_34764691", }); 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however, they did not articulate a common conception of martyrdom. Viewing Protestant and Catholic martyrologies and notions of martyrdom as essentially similar obscures highly significant confessional differences, which generated fiercely opposed constructions of martyrdom. This argument is examined through an analysis of the treatment of martyrs’ blood in English martyrological texts, since this encapsulated core confessional theologies.","downloadable_attachments":[{"id":54623845,"asset_id":34764691,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":30323831,"first_name":"Anastasia","last_name":"Stylianou","domain_name":"cambridge","page_name":"AnastasiaStylianou","display_name":"Anastasia Stylianou","profile_url":"https://cambridge.academia.edu/AnastasiaStylianou?f_ri=100732","photo":"https://0.academia-photos.com/30323831/9860922/14303080/s65_anastasia.stylianou.jpg"}],"research_interests":[{"id":1727,"name":"Early Modern History","url":"https://www.academia.edu/Documents/in/Early_Modern_History?f_ri=100732","nofollow":false},{"id":5132,"name":"Reformation History","url":"https://www.academia.edu/Documents/in/Reformation_History?f_ri=100732","nofollow":false},{"id":5133,"name":"Reformation 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and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7399525" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6604957c914170c8c1471d7e5c4cc5c8" rel="nofollow" data-download="{"attachment_id":48501373,"asset_id":7399525,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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href="https://www.academia.edu/13865525/Abnormally_differentiated_CD4_or_CD8_T_cells_with_phenotypic_and_genetic_features_of_double_negative_T_cells_in_human_Fas_deficiency">Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Accumulation of CD3(+) T-cell receptor (TCR)αβ(+)CD4(-)CD8(-) double-negative T cells (DNT) is a hallmark of autoimmune lymphoproliferative syndrome (ALPS). DNT origin and differentiation pathways remain controversial. Here we show that... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13865525" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Accumulation of CD3(+) T-cell receptor (TCR)αβ(+)CD4(-)CD8(-) double-negative T cells (DNT) is a hallmark of autoimmune lymphoproliferative syndrome (ALPS). DNT origin and differentiation pathways remain controversial. Here we show that human ALPS DNT have features of terminally differentiated effector memory T cells reexpressing CD45RA(+) (TEMRA), but are CD27(+)CD28(+)KLRG1(-) and do not express the transcription factor T-bet. This unique phenotype was also detected among CD4(+) or CD8(+) ALPS TEMRA cells. T-cell receptor β deep sequencing revealed a significant fraction of shared CDR3 sequences between ALPS DNT and both CD4(+) and CD8(+)TEMRA cells. Moreover, in ALPS patients with a germ line FAS mutation and somatic loss of heterozygosity, in whom biallelic mutant cells can be tracked by absent Fas expression, Fas-negative T cells accumulated not only among DNT, but also among CD4(+) and CD8(+)TEMRA cells. These data indicate that in human Fas deficiency DNT cannot only derive f...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13865525" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e6425a5262f1c4a9143dd9e6f0faff09" rel="nofollow" data-download="{"attachment_id":44863534,"asset_id":13865525,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44863534/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32952589" href="https://independent.academia.edu/SandraAmmann">Sandra Ammann</a><script data-card-contents-for-user="32952589" type="text/json">{"id":32952589,"first_name":"Sandra","last_name":"Ammann","domain_name":"independent","page_name":"SandraAmmann","display_name":"Sandra Ammann","profile_url":"https://independent.academia.edu/SandraAmmann?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13865525 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13865525"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13865525, container: ".js-paper-rank-work_13865525", }); 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These data indicate that in human Fas deficiency DNT cannot only derive f...","downloadable_attachments":[{"id":44863534,"asset_id":13865525,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32952589,"first_name":"Sandra","last_name":"Ammann","domain_name":"independent","page_name":"SandraAmmann","display_name":"Sandra Ammann","profile_url":"https://independent.academia.edu/SandraAmmann?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=100732","nofollow":false},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=100732","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false},{"id":125069,"name":"Genetic 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class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73609065" data-work_id="73609065" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73609065/Management_of_Cancer_Associated_Anemia_With_Erythropoiesis_Stimulating_Agents_ASCO_ASH_Clinical_Practice_Guideline_Update">Management of Cancer-Associated Anemia With Erythropoiesis-Stimulating Agents: ASCO/ASH Clinical Practice Guideline Update</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">PURPOSE To update the American Society of Clinical Oncology (ASCO)/American Society of Hematology (ASH) recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. METHODS PubMed and the Cochrane Library... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73609065" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">PURPOSE To update the American Society of Clinical Oncology (ASCO)/American Society of Hematology (ASH) recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. METHODS PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs in patients with cancer published from January 31, 2010, through May 14, 2018. For biosimilar ESAs, the literature search was expanded to include meta-analyses and RCTs in patients with cancer or chronic kidney disease and cohort studies in patients with cancer due to limited RCT evidence in the cancer setting. ASCO and ASH convened an Expert Panel to review the evidence and revise previous recommendations as needed. RESULTS The primary literature review included 15 meta-analyses of RCTs and two RCTs. A growing body of evidence suggests that adding iron to treatment with an ESA may improve hematopoietic response and reduce the likelihood of RBC transfusion. The biosimilar...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73609065" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="929d486414440d98fced5e3cd97a528e" rel="nofollow" data-download="{"attachment_id":82064896,"asset_id":73609065,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82064896/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37483926" href="https://independent.academia.edu/GiannisMountzios">Giannis Mountzios</a><script data-card-contents-for-user="37483926" type="text/json">{"id":37483926,"first_name":"Giannis","last_name":"Mountzios","domain_name":"independent","page_name":"GiannisMountzios","display_name":"Giannis Mountzios","profile_url":"https://independent.academia.edu/GiannisMountzios?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73609065 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73609065"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73609065, container: ".js-paper-rank-work_73609065", }); 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$(".js-view-count[data-work-id=73609065]").text(description); $(".js-view-count-work_73609065").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73609065").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73609065"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="100732" href="https://www.academia.edu/Documents/in/Blood">Blood</a>, <script data-card-contents-for-ri="100732" type="text/json">{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="115895" href="https://www.academia.edu/Documents/in/Clinical_oncology">Clinical oncology</a><script data-card-contents-for-ri="115895" type="text/json">{"id":115895,"name":"Clinical oncology","url":"https://www.academia.edu/Documents/in/Clinical_oncology?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73609065]'), work: {"id":73609065,"title":"Management of Cancer-Associated Anemia With Erythropoiesis-Stimulating Agents: ASCO/ASH Clinical Practice Guideline Update","created_at":"2022-03-12T08:37:58.613-08:00","url":"https://www.academia.edu/73609065/Management_of_Cancer_Associated_Anemia_With_Erythropoiesis_Stimulating_Agents_ASCO_ASH_Clinical_Practice_Guideline_Update?f_ri=100732","dom_id":"work_73609065","summary":"PURPOSE To update the American Society of Clinical Oncology (ASCO)/American Society of Hematology (ASH) recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. METHODS PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs in patients with cancer published from January 31, 2010, through May 14, 2018. For biosimilar ESAs, the literature search was expanded to include meta-analyses and RCTs in patients with cancer or chronic kidney disease and cohort studies in patients with cancer due to limited RCT evidence in the cancer setting. ASCO and ASH convened an Expert Panel to review the evidence and revise previous recommendations as needed. RESULTS The primary literature review included 15 meta-analyses of RCTs and two RCTs. A growing body of evidence suggests that adding iron to treatment with an ESA may improve hematopoietic response and reduce the likelihood of RBC transfusion. The biosimilar...","downloadable_attachments":[{"id":82064896,"asset_id":73609065,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37483926,"first_name":"Giannis","last_name":"Mountzios","domain_name":"independent","page_name":"GiannisMountzios","display_name":"Giannis Mountzios","profile_url":"https://independent.academia.edu/GiannisMountzios?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false},{"id":115895,"name":"Clinical oncology","url":"https://www.academia.edu/Documents/in/Clinical_oncology?f_ri=100732","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_72416082" data-work_id="72416082" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72416082/Diagnosis_and_management_of_acute_myeloid_leukemia_in_adults_recommendations_from_an_international_expert_panel_on_behalf_of_the_European_LeukemiaNet">Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72416082" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion–based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72416082" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cc3e3fa31f63c5bc2e96840678b8509f" rel="nofollow" data-download="{"attachment_id":81355517,"asset_id":72416082,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81355517/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39232709" href="https://independent.academia.edu/DonnaJohnston3">Donna Johnston</a><script data-card-contents-for-user="39232709" type="text/json">{"id":39232709,"first_name":"Donna","last_name":"Johnston","domain_name":"independent","page_name":"DonnaJohnston3","display_name":"Donna Johnston","profile_url":"https://independent.academia.edu/DonnaJohnston3?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_72416082 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72416082"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72416082, container: ".js-paper-rank-work_72416082", }); });</script></li><li class="js-percentile-work_72416082 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72416082; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_72416082"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_72416082 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="72416082"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72416082; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72416082]").text(description); $(".js-view-count-work_72416082").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_72416082").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="72416082"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="619" href="https://www.academia.edu/Documents/in/Hematology">Hematology</a>, <script data-card-contents-for-ri="619" type="text/json">{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="634" href="https://www.academia.edu/Documents/in/General_Practice">General Practice</a>, <script data-card-contents-for-ri="634" type="text/json">{"id":634,"name":"General Practice","url":"https://www.academia.edu/Documents/in/General_Practice?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4531" href="https://www.academia.edu/Documents/in/Clinical_Trial">Clinical Trial</a>, <script data-card-contents-for-ri="4531" type="text/json">{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a><script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=72416082]'), work: {"id":72416082,"title":"Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet","created_at":"2022-02-24T07:26:53.491-08:00","url":"https://www.academia.edu/72416082/Diagnosis_and_management_of_acute_myeloid_leukemia_in_adults_recommendations_from_an_international_expert_panel_on_behalf_of_the_European_LeukemiaNet?f_ri=100732","dom_id":"work_72416082","summary":"In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion–based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.","downloadable_attachments":[{"id":81355517,"asset_id":72416082,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39232709,"first_name":"Donna","last_name":"Johnston","domain_name":"independent","page_name":"DonnaJohnston3","display_name":"Donna Johnston","profile_url":"https://independent.academia.edu/DonnaJohnston3?f_ri=100732","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology?f_ri=100732","nofollow":false},{"id":634,"name":"General Practice","url":"https://www.academia.edu/Documents/in/General_Practice?f_ri=100732","nofollow":false},{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=100732","nofollow":false},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=100732","nofollow":false},{"id":12054,"name":"International Cooperation","url":"https://www.academia.edu/Documents/in/International_Cooperation?f_ri=100732"},{"id":19632,"name":"Molecular Genetics","url":"https://www.academia.edu/Documents/in/Molecular_Genetics?f_ri=100732"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=100732"},{"id":59057,"name":"Acute Myeloid Leukemia","url":"https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia?f_ri=100732"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=100732"},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732"},{"id":147861,"name":"Expert Opinion","url":"https://www.academia.edu/Documents/in/Expert_Opinion?f_ri=100732"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=100732"},{"id":410532,"name":"Clinical Data","url":"https://www.academia.edu/Documents/in/Clinical_Data?f_ri=100732"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=100732"},{"id":906958,"name":"Disease Management","url":"https://www.academia.edu/Documents/in/Disease_Management?f_ri=100732"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=100732"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_67698007" data-work_id="67698007" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/67698007/Evaluation_of_Direct_Susceptibility_Testing_for_Monomicrobial_Growth_from_Bactec_Blood_Culture_Bottles_A_Pilot_Study">Evaluation of Direct Susceptibility Testing for Monomicrobial Growth from Bactec Blood Culture Bottles- A Pilot Study</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/67698007" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8298abf5d0aa28ac43308963e37ab12b" rel="nofollow" data-download="{"attachment_id":78426527,"asset_id":67698007,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78426527/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="106869070" href="https://independent.academia.edu/juancarlospidone">juan carlos pidone</a><script data-card-contents-for-user="106869070" type="text/json">{"id":106869070,"first_name":"juan carlos","last_name":"pidone","domain_name":"independent","page_name":"juancarlospidone","display_name":"juan carlos pidone","profile_url":"https://independent.academia.edu/juancarlospidone?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_67698007 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="67698007"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 67698007, container: ".js-paper-rank-work_67698007", }); });</script></li><li class="js-percentile-work_67698007 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67698007; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_67698007"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_67698007 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="67698007"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67698007; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67698007]").text(description); $(".js-view-count-work_67698007").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_67698007").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="67698007"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9813" href="https://www.academia.edu/Documents/in/Argentina">Argentina</a>, <script data-card-contents-for-ri="9813" type="text/json">{"id":9813,"name":"Argentina","url":"https://www.academia.edu/Documents/in/Argentina?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="100732" href="https://www.academia.edu/Documents/in/Blood">Blood</a><script data-card-contents-for-ri="100732" type="text/json">{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=67698007]'), work: {"id":67698007,"title":"Evaluation of Direct Susceptibility Testing for Monomicrobial Growth from Bactec Blood Culture Bottles- A Pilot Study","created_at":"2022-01-09T12:33:35.615-08:00","url":"https://www.academia.edu/67698007/Evaluation_of_Direct_Susceptibility_Testing_for_Monomicrobial_Growth_from_Bactec_Blood_Culture_Bottles_A_Pilot_Study?f_ri=100732","dom_id":"work_67698007","summary":null,"downloadable_attachments":[{"id":78426527,"asset_id":67698007,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":106869070,"first_name":"juan carlos","last_name":"pidone","domain_name":"independent","page_name":"juancarlospidone","display_name":"juan carlos 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Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=100732","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=100732","nofollow":false},{"id":15917,"name":"Clostridium difficile","url":"https://www.academia.edu/Documents/in/Clostridium_difficile?f_ri=100732","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732"},{"id":111007,"name":"Antimicrobial activity","url":"https://www.academia.edu/Documents/in/Antimicrobial_activity?f_ri=100732"},{"id":125076,"name":"Sepsis","url":"https://www.academia.edu/Documents/in/Sepsis?f_ri=100732"},{"id":509981,"name":"Antimicrobial agents","url":"https://www.academia.edu/Documents/in/Antimicrobial_agents?f_ri=100732"},{"id":897823,"name":"Elsevier","url":"https://www.academia.edu/Documents/in/Elsevier?f_ri=100732"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=100732"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70126838 coauthored" data-work_id="70126838" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70126838/_Personnel_at_risk_for_occupational_blood_exposure_in_a_university_hospital_in_West_Algeria_">[Personnel at risk for occupational blood exposure in a university hospital in West Algeria]</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The accidental occupational exposure of health care workers to blood or other body fluids after skin injury or mucous contact, constitutes a risk for the transmission of the hepatitis B virus (HBV), hepatitis C virus (HCV) or human... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70126838" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The accidental occupational exposure of health care workers to blood or other body fluids after skin injury or mucous contact, constitutes a risk for the transmission of the hepatitis B virus (HBV), hepatitis C virus (HCV) or human immunodeficiency viruses (HIV). This paper presents the results of a survey carried out over two years (January 2005 - December 2006) on reported occupational blood exposures (OBE). The study aimed to determine incidence, workers and professional categories at risk, and circumstances of OBE occurrence in order to identify avoidable cases and to orient prevention measures. Personal and professional data, immunization status, circumstances of OBE incidents, preventive measures, workers&#39; behaviour post-exposure, and serology surveillance were collected. 108 exposures were reported by 70 women and 38 men. In total, 44 accidents were reported in 2005, and 64 in 2006. Needle stick injuries represented 81% of cases. Source patient serology was unknown in mos...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70126838" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43340571" href="https://independent.academia.edu/benalibeghdadli">benali beghdadli</a><script data-card-contents-for-user="43340571" type="text/json">{"id":43340571,"first_name":"benali","last_name":"beghdadli","domain_name":"independent","page_name":"benalibeghdadli","display_name":"benali beghdadli","profile_url":"https://independent.academia.edu/benalibeghdadli?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-70126838">+1</span><div class="hidden js-additional-users-70126838"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/ghomariothmane">ghomari othmane</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-70126838'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-70126838').html(); 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This paper presents the results of a survey carried out over two years (January 2005 - December 2006) on reported occupational blood exposures (OBE). The study aimed to determine incidence, workers and professional categories at risk, and circumstances of OBE occurrence in order to identify avoidable cases and to orient prevention measures. Personal and professional data, immunization status, circumstances of OBE incidents, preventive measures, workers\u0026#39; behaviour post-exposure, and serology surveillance were collected. 108 exposures were reported by 70 women and 38 men. In total, 44 accidents were reported in 2005, and 64 in 2006. Needle stick injuries represented 81% of cases. Source patient serology was unknown in mos...","downloadable_attachments":[],"ordered_authors":[{"id":43340571,"first_name":"benali","last_name":"beghdadli","domain_name":"independent","page_name":"benalibeghdadli","display_name":"benali beghdadli","profile_url":"https://independent.academia.edu/benalibeghdadli?f_ri=100732","photo":"/images/s65_no_pic.png"},{"id":214804374,"first_name":"ghomari","last_name":"othmane","domain_name":"independent","page_name":"ghomariothmane","display_name":"ghomari othmane","profile_url":"https://independent.academia.edu/ghomariothmane?f_ri=100732","photo":"https://0.academia-photos.com/214804374/73452362/61933879/s65_ghomari.othmane.png"}],"research_interests":[{"id":75836,"name":"Algeria","url":"https://www.academia.edu/Documents/in/Algeria?f_ri=100732","nofollow":false},{"id":100732,"name":"Blood","url":"https://www.academia.edu/Documents/in/Blood?f_ri=100732","nofollow":false},{"id":192721,"name":"Risk 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u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/68681651/Evaluation_of_immunologic_profile_in_patients_with_nickel_sensitivity_due_to_use_of_fixed_orthodontic_appliances">Evaluation of immunologic profile in patients with nickel sensitivity due to use of fixed orthodontic appliances</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/68681651" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a70c6f0e05e017f29d308061e5f25498" rel="nofollow" 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type="text/json">{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2702" href="https://www.academia.edu/Documents/in/Immune_response">Immune response</a>, <script data-card-contents-for-ri="2702" type="text/json">{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=68681651]'), work: {"id":68681651,"title":"Evaluation of immunologic profile in patients with nickel sensitivity due to use of fixed orthodontic appliances","created_at":"2022-01-19T05:39:21.841-08:00","url":"https://www.academia.edu/68681651/Evaluation_of_immunologic_profile_in_patients_with_nickel_sensitivity_due_to_use_of_fixed_orthodontic_appliances?f_ri=100732","dom_id":"work_68681651","summary":null,"downloadable_attachments":[{"id":79077427,"asset_id":68681651,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":4440888,"first_name":"Alexandre","last_name":"Sylvio","domain_name":"independent","page_name":"AlexandreSylvio","display_name":"Alexandre Sylvio","profile_url":"https://independent.academia.edu/AlexandreSylvio?f_ri=100732","photo":"https://0.academia-photos.com/4440888/1812721/2159733/s65_alexandre.sylvio.jpg"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=100732","nofollow":false},{"id":1131,"name":"Biomedical 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/65583741/Treatment_of_acute_renal_failure_in_an_infant_using_continuous_arteriovenous_hemofiltration">Treatment of acute renal failure in an infant using continuous arteriovenous hemofiltration</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/65583741" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="da550e2b69362557a2d511ab5c9b8230" rel="nofollow" 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type="text/json">{"id":76433849,"first_name":"Juan","last_name":"Bosch","domain_name":"independent","page_name":"JuanBosch4","display_name":"Juan Bosch","profile_url":"https://independent.academia.edu/JuanBosch4?f_ri=100732","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_65583741 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="65583741"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 65583741, container: ".js-paper-rank-work_65583741", }); });</script></li><li class="js-percentile-work_65583741 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65583741; 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injury","url":"https://www.academia.edu/Documents/in/Acute_kidney_injury?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=100732","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37447" href="https://www.academia.edu/Documents/in/Ultrafiltration">Ultrafiltration</a><script data-card-contents-for-ri="37447" type="text/json">{"id":37447,"name":"Ultrafiltration","url":"https://www.academia.edu/Documents/in/Ultrafiltration?f_ri=100732","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=65583741]'), work: {"id":65583741,"title":"Treatment of acute renal failure in an infant using continuous arteriovenous 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Vinblastine alters sphingolipid metabolism to enhance the sensitivity of AML to nanoliposomal C6-ceramide.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/53830559" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3b34867744f51ea69fcd5c555ae327c7" rel="nofollow" data-download="{"attachment_id":70488357,"asset_id":53830559,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70488357/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="55029409" href="https://pcom.academia.edu/ReginaOndrasik">Regina M . 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href="https://www.academia.edu/47248339/Biosimilar_G_CSF_based_mobilization_of_peripheral_blood_hematopoietic_stem_cells_for_autologous_and_allogeneic_stem_cell_transplantation">Biosimilar G-CSF based mobilization of peripheral blood hematopoietic stem cells for autologous and allogeneic stem cell transplantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The use of granulocyte colony stimulating factor (G-CSF) biosimilars for peripheral blood hematopoietic stem cell (PBSC) mobilization has stimulated an ongoing debate regarding their efficacy and safety. However, the use of biosimilar... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_47248339" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The use of granulocyte colony stimulating factor (G-CSF) biosimilars for peripheral blood hematopoietic stem cell (PBSC) mobilization has stimulated an ongoing debate regarding their efficacy and safety. However, the use of biosimilar G-CSF was approved by the European Medicines Agency (EMA) for all the registered indications of the originator G-CSF (Neupogen (®) ) including mobilization of stem cells. Here, we performed a comprehensive review of published reports on the use of biosimilar G-CSF covering patients with hematological malignancies as well as healthy donors that underwent stem cell mobilization at multiple centers using site-specific non-randomized regimens with a biosimilar G-CSF in the autologous and allogeneic setting. A total of 904 patients mostly with hematological malignancies as well as healthy donors underwent successful autologous or allogeneic stem cell mobilization, respectively, using a biosimilar G-CSF (520 with Ratiograstim®/Tevagrastim, 384 with Zarzio®)....</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47248339" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="43c952c614d68e681e1aac4596ae8cc9" rel="nofollow" data-download="{"attachment_id":66441469,"asset_id":47248339,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66441469/download_file?st=MTczMjc1MTE5NCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39376468" href="https://soton.academia.edu/KOrchard">K. 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