CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available" lang="en" dir="ltr"> <head> <meta charset="UTF-8"> <title>ITPR3 - Wikipedia</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )enwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":["",""],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"dmy", "wgMonthNames":["","January","February","March","April","May","June","July","August","September","October","November","December"],"wgRequestId":"3133f518-3cb1-4ade-a870-979d176dd30d","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"ITPR3","wgTitle":"ITPR3","wgCurRevisionId":1196420604,"wgRevisionId":1196420604,"wgArticleId":18419322,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["Articles with short description","Short description matches Wikidata","All stub articles","Genes on human chromosome 6","Ion channels","Membrane protein stubs"],"wgPageViewLanguage":"en","wgPageContentLanguage":"en","wgPageContentModel":"wikitext","wgRelevantPageName":"ITPR3","wgRelevantArticleId":18419322,"wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false, "wgFlaggedRevsParams":{"tags":{"status":{"levels":1}}},"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"en","pageLanguageDir":"ltr","pageVariantFallbacks":"en"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":false,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":9000,"wgRelatedArticlesCompat":[],"wgCentralAuthMobileDomain":false,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q18028078","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false,"wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false};RLSTATE={ "ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"};RLPAGEMODULES=["ext.cite.ux-enhancements","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.ReferenceTooltips","ext.gadget.switcher","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups","ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents", "ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession","wikibase.sidebar.tracking"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=en&modules=ext.cite.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=en&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=en&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.4"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/3/3c/IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png/1200px-IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="937"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/3/3c/IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png/800px-IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="624"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/3/3c/IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png/640px-IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="500"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="ITPR3 - Wikipedia"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//en.m.wikipedia.org/wiki/ITPR3"> <link rel="alternate" type="application/x-wiki" title="Edit this page" href="/w/index.php?title=ITPR3&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (en)"> <link rel="EditURI" type="application/rsd+xml" href="//en.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://en.wikipedia.org/wiki/ITPR3"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en"> <link rel="alternate" type="application/atom+xml" title="Wikipedia Atom feed" href="/w/index.php?title=Special:RecentChanges&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="//login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-ITPR3 rootpage-ITPR3 skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Jump to content</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Main menu" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Main menu</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Main menu</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">hide</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigation </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Main_Page" title="Visit the main page [z]" accesskey="z"><span>Main page</span></a></li><li id="n-contents" class="mw-list-item"><a href="/wiki/Wikipedia:Contents" title="Guides to browsing Wikipedia"><span>Contents</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:Current_events" title="Articles related to current events"><span>Current events</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Special:Random" title="Visit a randomly selected article [x]" accesskey="x"><span>Random article</span></a></li><li id="n-aboutsite" class="mw-list-item"><a href="/wiki/Wikipedia:About" title="Learn about Wikipedia and how it works"><span>About Wikipedia</span></a></li><li id="n-contactpage" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us" title="How to contact Wikipedia"><span>Contact us</span></a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" > <div class="vector-menu-heading"> Contribute </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Help:Contents" title="Guidance on how to use and edit Wikipedia"><span>Help</span></a></li><li id="n-introduction" class="mw-list-item"><a href="/wiki/Help:Introduction" title="Learn how to edit Wikipedia"><span>Learn to edit</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Community_portal" title="The hub for editors"><span>Community portal</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Special:RecentChanges" title="A list of recent changes to Wikipedia [r]" accesskey="r"><span>Recent changes</span></a></li><li id="n-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_upload_wizard" title="Add images or other media for use on Wikipedia"><span>Upload file</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Main_Page" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="The Free Encyclopedia" src="/static/images/mobile/copyright/wikipedia-tagline-en.svg" width="117" height="13" style="width: 7.3125em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Special:Search" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Search Wikipedia [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Search</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Search Wikipedia" aria-label="Search Wikipedia" autocapitalize="sentences" title="Search Wikipedia [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Special:Search"> </div> <button class="cdx-button cdx-search-input__end-button">Search</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Personal tools"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Appearance" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Appearance</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en" class=""><span>Donate</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:CreateAccount&returnto=ITPR3" title="You are encouraged to create an account and log in; however, it is not mandatory" class=""><span>Create account</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:UserLogin&returnto=ITPR3" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o" class=""><span>Log in</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Log in and more options" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Personal tools" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Personal tools</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="User menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en"><span>Donate</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:CreateAccount&returnto=ITPR3" title="You are encouraged to create an account and log in; however, it is not mandatory"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Create account</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:UserLogin&returnto=ITPR3" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Log in</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pages for logged out editors <a href="/wiki/Help:Introduction" aria-label="Learn more about editing"><span>learn more</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:MyContributions" title="A list of edits made from this IP address [y]" accesskey="y"><span>Contributions</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:MyTalk" title="Discussion about edits from this IP address [n]" accesskey="n"><span>Talk</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Contents" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Contents</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">ITPR3</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 3 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-3" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">3 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/ITPR3" title="ITPR3 – Portuguese" lang="pt" hreflang="pt" data-title="ITPR3" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/ITPR3" title="ITPR3 – Tatar" lang="tt" hreflang="tt" data-title="ITPR3" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/ITPR3" title="ITPR3 – Ukrainian" lang="uk" hreflang="uk" data-title="ITPR3" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18028078#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/ITPR3" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:ITPR3" rel="discussion" title="Discuss improvements to the content page [t]" accesskey="t"><span>Talk</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Change language variant" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">English</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Views"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/ITPR3"><span>Read</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=ITPR3&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=ITPR3&action=history" title="Past revisions of this page [h]" accesskey="h"><span>View history</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Tools" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Tools</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Tools</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">hide</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="More options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/ITPR3"><span>Read</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=ITPR3&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=ITPR3&action=history"><span>View history</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> General </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:WhatLinksHere/ITPR3" title="List of all English Wikipedia pages containing links to this page [j]" accesskey="j"><span>What links here</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:RecentChangesLinked/ITPR3" rel="nofollow" title="Recent changes in pages linked from this page [k]" accesskey="k"><span>Related changes</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_Upload_Wizard" title="Upload files [u]" accesskey="u"><span>Upload file</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Special:SpecialPages" title="A list of all special pages [q]" accesskey="q"><span>Special pages</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=ITPR3&oldid=1196420604" title="Permanent link to this revision of this page"><span>Permanent link</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=ITPR3&action=info" title="More information about this page"><span>Page information</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:CiteThisPage&page=ITPR3&id=1196420604&wpFormIdentifier=titleform" title="Information on how to cite this page"><span>Cite this page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:UrlShortener&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FITPR3"><span>Get shortened URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FITPR3"><span>Download QR code</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=ITPR3&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=ITPR3&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q18028078" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">ITPR3</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:IP3_receptor_type_3_(ITPR3)_-_6DQN.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3c/IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png/250px-IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png" decoding="async" width="250" height="195" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3c/IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png/375px-IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3c/IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png/500px-IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png 2x" data-file-width="2050" data-file-height="1600" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P70227%20or%20Q14573">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P70227,Q14573">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3JRR">3JRR</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/6182">ITPR3</a></span>, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/147267">147267</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:96624">96624</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=1675">1675</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ITPR3">ITPR3</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000096433">ITPR3 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_6.svg" class="mw-file-description" title="Chromosome 6 (human)"><img alt="Chromosome 6 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/300px-Ideogram_human_chromosome_6.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/450px-Ideogram_human_chromosome_6.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/600px-Ideogram_human_chromosome_6.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_6_(human)" class="mw-redirect" title="Chromosome 6 (human)">Chromosome 6 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_6_ideogram.svg" class="mw-file-description" title="Chromosome 6 (human)"><img alt="Chromosome 6 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/300px-Human_chromosome_6_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/450px-Human_chromosome_6_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/600px-Human_chromosome_6_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 52.560929699875px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ITPR3"><img alt="Genomic location for ITPR3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 58.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ITPR3"><img alt="Genomic location for ITPR3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">6p21.31</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">33,620,365 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">33,696,574 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_17.svg" class="mw-file-description" title="Chromosome 17 (mouse)"><img alt="Chromosome 17 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_17.svg/260px-Ideogram_house_mouse_chromosome_17.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_17.svg/390px-Ideogram_house_mouse_chromosome_17.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_17.svg/520px-Ideogram_house_mouse_chromosome_17.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 17 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_17.svg" class="mw-file-description" title="Chromosome 17 (mouse)"><img alt="Chromosome 17 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/Ideogram_of_house_mouse_chromosome_17.svg/300px-Ideogram_of_house_mouse_chromosome_17.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/Ideogram_of_house_mouse_chromosome_17.svg/450px-Ideogram_of_house_mouse_chromosome_17.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/47/Ideogram_of_house_mouse_chromosome_17.svg/600px-Ideogram_of_house_mouse_chromosome_17.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 79.162976325902px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ITPR3"><img alt="Genomic location for ITPR3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 85.2px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ITPR3"><img alt="Genomic location for ITPR3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">17 A3.3|17 13.68 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">27,276,278 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">27,341,197 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000096433">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">cartilage tissue</li><br /><li style="line-height: 137%;">pylorus</li><br /><li style="line-height: 137%;">skin of arm</li><br /><li style="line-height: 137%;">trigeminal ganglion</li><br /><li style="line-height: 137%;">sural nerve</li><br /><li style="line-height: 137%;">skin of thigh</li><br /><li style="line-height: 137%;">olfactory bulb</li><br /><li style="line-height: 137%;">left lobe of thyroid gland</li><br /><li style="line-height: 137%;">spinal ganglia</li><br /><li style="line-height: 137%;">right lobe of thyroid gland</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000042644">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">molar</li><br /><li style="line-height: 137%;">pyloric antrum</li><br /><li style="line-height: 137%;">epithelium of stomach</li><br /><li style="line-height: 137%;">skin of external ear</li><br /><li style="line-height: 137%;">mucous cell of stomach</li><br /><li style="line-height: 137%;">lip</li><br /><li style="line-height: 137%;">epithelium of small intestine</li><br /><li style="line-height: 137%;">sciatic nerve</li><br /><li style="line-height: 137%;">rib</li><br /><li style="line-height: 137%;">left colon</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000096433">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005262">calcium channel activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005220">inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005216">ion channel activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043533">inositol 1,3,4,5 tetrakisphosphate binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015278">calcium-release channel activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000822">inositol hexakisphosphate binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070679">inositol 1,4,5 trisphosphate binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005509">calcium ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035091">phosphatidylinositol binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005789">endoplasmic reticulum membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043235">receptor complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045177">apical part of cell</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005730">nucleolus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031095">platelet dense tubular network membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005783">endoplasmic reticulum</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005903">brush border</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005640">nuclear outer membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043209">myelin sheath</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043025">soma</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016529">sarcoplasmic reticulum</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030659">cytoplasmic vesicle membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030667">secretory granule membrane</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050917">sensory perception of umami taste</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060402">calcium ion transport into cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1903779">regulation of cardiac conduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050796">regulation of insulin secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007613">memory</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006811">ion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030168">platelet activation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051592">response to calcium ion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050913">sensory perception of bitter taste</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070588">calcium ion transmembrane transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0055085">transmembrane transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050916">sensory perception of sweet taste</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048016">inositol phosphate-mediated signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006816">calcium ion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060291">long-term potentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007186">G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007204">positive regulation of cytosolic calcium ion concentration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051260">protein homooligomerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051291">protein heterooligomerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051209">release of sequestered calcium ion into cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006810">transport</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=3710&rn=1">3710</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=16440&rn=1">16440</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000096433;db=core">ENSG00000096433</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000042644;db=core">ENSMUSG00000042644</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q14573">Q14573</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P70227">P70227</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_002224">NM_002224</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_080553">NM_080553</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_002215">NP_002215</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_542120">NP_542120</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr6:33620365-33696574">Chr 6: 33.62 – 33.7 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr17:27276278-27341197">Chr 17: 27.28 – 27.34 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18028078" class="extiw" title="d:Q18028078">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18251746" class="extiw" title="d:Q18251746">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Inositol 1,4,5-trisphosphate receptor, type 3</b>, also known as <b>ITPR3</b>, is a <a href="/wiki/Protein" title="Protein">protein</a> which in humans is encoded by the <i>ITPR3</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-entrez_5-0" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/Protein" title="Protein">protein</a> encoded by this gene is both a <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptor</a> for <a href="/wiki/Inositol_triphosphate" class="mw-redirect" title="Inositol triphosphate">inositol triphosphate</a> and a <a href="/wiki/Calcium_channel" title="Calcium channel">calcium channel</a>.<sup id="cite_ref-pmid8081734_6-0" class="reference"><a href="#cite_note-pmid8081734-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ITPR3&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ITP3 channels serve an important role in the taste transduction pathway of <a href="/wiki/Sweet" class="mw-redirect" title="Sweet">sweet</a>, <a href="/wiki/Bitter_(taste)" class="mw-redirect" title="Bitter (taste)">bitter</a> and <a href="/wiki/Umami" title="Umami">umami</a> tastes the <a href="/wiki/Gustatory_system" class="mw-redirect" title="Gustatory system">gustatory system</a>. ITP3 channels allow the flow of Calcium out of the <a href="/wiki/Endoplasmic_reticulum" title="Endoplasmic reticulum">endoplasmic reticulum</a> in response to IP3. Calcium cations result in the activation of <a href="/wiki/TRPM5" title="TRPM5">TRPM5</a> which leads to a depolarisation generating potential and an <a href="/wiki/Action_potential" title="Action potential">action potential</a>.<sup id="cite_ref-pmid20696704_7-0" class="reference"><a href="#cite_note-pmid20696704-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ITPR3&action=edit&section=2" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Inositol_trisphosphate_receptor" title="Inositol trisphosphate receptor">Inositol trisphosphate receptor</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ITPR3&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000096433">GRCh38: Ensembl release 89: ENSG00000096433</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000042644">GRCm38: Ensembl release 89: ENSMUSG00000042644</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=3710">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D3710&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=16440">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D16440&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></span> </li> <li id="cite_note-entrez-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-entrez_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3710">"Entrez Gene: inositol 1"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+inositol+1&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D3710&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></span> </li> <li id="cite_note-pmid8081734-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8081734_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYamamoto-HinoSugiyamaHikichi1994" class="citation journal cs1">Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". <i>Recept. Channels</i>. <b>2</b> (1): 9–22. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8081734">8081734</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Recept.+Channels&rft.atitle=Cloning+and+characterization+of+human+type+2+and+type+3+inositol+1%2C4%2C5-trisphosphate+receptors&rft.volume=2&rft.issue=1&rft.pages=9-22&rft.date=1994&rft_id=info%3Apmid%2F8081734&rft.aulast=Yamamoto-Hino&rft.aufirst=M&rft.au=Sugiyama%2C+T&rft.au=Hikichi%2C+K&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></span> </li> <li id="cite_note-pmid20696704-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid20696704_7-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChaudhariRoper2010" class="citation journal cs1">Chaudhari N, Roper SD (August 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922655">"The cell biology of taste"</a>. <i>J. Cell Biol</i>. <b>190</b> (3): 285–96. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.201003144">10.1083/jcb.201003144</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922655">2922655</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20696704">20696704</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Biol.&rft.atitle=The+cell+biology+of+taste&rft.volume=190&rft.issue=3&rft.pages=285-96&rft.date=2010-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2922655%23id-name%3DPMC&rft_id=info%3Apmid%2F20696704&rft_id=info%3Adoi%2F10.1083%2Fjcb.201003144&rft.aulast=Chaudhari&rft.aufirst=N&rft.au=Roper%2C+SD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2922655&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ITPR3&action=edit&section=4" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKlineCunhaLowe2008" class="citation journal cs1">Kline CF, Cunha SR, Lowe JS, et al. (2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858327">"Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor"</a>. <i>J. Cell. Biochem</i>. <b>104</b> (4): 1244–53. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjcb.21704">10.1002/jcb.21704</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858327">2858327</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18275062">18275062</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell.+Biochem.&rft.atitle=Revisiting+ankyrin-InsP3+receptor+interactions%3A+ankyrin-B+associates+with+the+cytoplasmic+N-terminus+of+the+InsP3+receptor&rft.volume=104&rft.issue=4&rft.pages=1244-53&rft.date=2008&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2858327%23id-name%3DPMC&rft_id=info%3Apmid%2F18275062&rft_id=info%3Adoi%2F10.1002%2Fjcb.21704&rft.aulast=Kline&rft.aufirst=CF&rft.au=Cunha%2C+SR&rft.au=Lowe%2C+JS&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2858327&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOishiIidaOtsubo2008" class="citation journal cs1">Oishi T, Iida A, Otsubo S, et al. (2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs10038-007-0233-3">"A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population"</a>. <i>J. Hum. Genet</i>. <b>53</b> (2): 151–62. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs10038-007-0233-3">10.1007/s10038-007-0233-3</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18219441">18219441</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Hum.+Genet.&rft.atitle=A+functional+SNP+in+the+NKX2.5-binding+site+of+ITPR3+promoter+is+associated+with+susceptibility+to+systemic+lupus+erythematosus+in+Japanese+population&rft.volume=53&rft.issue=2&rft.pages=151-62&rft.date=2008&rft_id=info%3Adoi%2F10.1007%2Fs10038-007-0233-3&rft_id=info%3Apmid%2F18219441&rft.aulast=Oishi&rft.aufirst=T&rft.au=Iida%2C+A&rft.au=Otsubo%2C+S&rft_id=https%3A%2F%2Fdoi.org%2F10.1007%252Fs10038-007-0233-3&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHiroseStuyversDun2008" class="citation journal cs1">Hirose M, Stuyvers B, Dun W, et al. (2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566512">"Wide long lasting perinuclear Ca<sup>2+</sup> release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells"</a>. <i>J. Mol. Cell. Cardiol</i>. <b>45</b> (2): 176–84. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.yjmcc.2008.05.008">10.1016/j.yjmcc.2008.05.008</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566512">2566512</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18586264">18586264</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Mol.+Cell.+Cardiol.&rft.atitle=Wide+long+lasting+perinuclear+Ca%3Csup%3E2%2B%3C%2Fsup%3E+release+events+generated+by+an+interaction+between+ryanodine+and+IP3+receptors+in+canine+Purkinje+cells&rft.volume=45&rft.issue=2&rft.pages=176-84&rft.date=2008&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2566512%23id-name%3DPMC&rft_id=info%3Apmid%2F18586264&rft_id=info%3Adoi%2F10.1016%2Fj.yjmcc.2008.05.008&rft.aulast=Hirose&rft.aufirst=M&rft.au=Stuyvers%2C+B&rft.au=Dun%2C+W&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2566512&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMiyachiIwaiAsada2007" class="citation journal cs1">Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". <i>Mod Rheumatol</i>. <b>17</b> (2): 137–43. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs10165-006-0555-6">10.1007/s10165-006-0555-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17437169">17437169</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:36516047">36516047</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mod+Rheumatol&rft.atitle=Inositol+1%2C4%2C5-trisphosphate+receptors+are+autoantibody+target+antigens+in+patients+with+Sj%C3%B6gren%27s+syndrome+and+other+systemic+rheumatic+diseases&rft.volume=17&rft.issue=2&rft.pages=137-43&rft.date=2007&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A36516047%23id-name%3DS2CID&rft_id=info%3Apmid%2F17437169&rft_id=info%3Adoi%2F10.1007%2Fs10165-006-0555-6&rft.aulast=Miyachi&rft.aufirst=K&rft.au=Iwai%2C+M&rft.au=Asada%2C+K&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTangGuoWang2009" class="citation journal cs1">Tang TS, Guo C, Wang H, et al. (2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768402">"Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model"</a>. <i>J. Neurosci</i>. <b>29</b> (5): 1257–66. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.4411-08.2009">10.1523/JNEUROSCI.4411-08.2009</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768402">2768402</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19193873">19193873</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Neurosci.&rft.atitle=Neuroprotective+effects+of+inositol+1%2C4%2C5-trisphosphate+receptor+C-terminal+fragment+in+a+Huntington%27s+disease+mouse+model&rft.volume=29&rft.issue=5&rft.pages=1257-66&rft.date=2009&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2768402%23id-name%3DPMC&rft_id=info%3Apmid%2F19193873&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.4411-08.2009&rft.aulast=Tang&rft.aufirst=TS&rft.au=Guo%2C+C&rft.au=Wang%2C+H&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2768402&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNagaleekarDiehlJuncadella2008" class="citation journal cs1">Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756541">"IP3 receptor-mediated Ca<sup>2+</sup> release in naive CD4 T cells dictates their cytokine program"</a>. <i>J. Immunol</i>. <b>181</b> (12): 8315–22. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4049%2Fjimmunol.181.12.8315">10.4049/jimmunol.181.12.8315</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756541">2756541</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19050248">19050248</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Immunol.&rft.atitle=IP3+receptor-mediated+Ca%3Csup%3E2%2B%3C%2Fsup%3E+release+in+naive+CD4+T+cells+dictates+their+cytokine+program&rft.volume=181&rft.issue=12&rft.pages=8315-22&rft.date=2008&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2756541%23id-name%3DPMC&rft_id=info%3Apmid%2F19050248&rft_id=info%3Adoi%2F10.4049%2Fjimmunol.181.12.8315&rft.aulast=Nagaleekar&rft.aufirst=VK&rft.au=Diehl%2C+SA&rft.au=Juncadella%2C+I&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2756541&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBandyopadhyaySwaimLiu2005" class="citation journal cs1">Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M410013200">"Apical localization of a functional TRPC3/TRPC6-Ca<sup>2+</sup>-signaling complex in polarized epithelial cells. Role in apical Ca<sup>2+</sup> influx"</a>. <i>J. Biol. Chem</i>. <b>280</b> (13): 12908–16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M410013200">10.1074/jbc.M410013200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15623527">15623527</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Apical+localization+of+a+functional+TRPC3%2FTRPC6-Ca%3Csup%3E2%2B%3C%2Fsup%3E-signaling+complex+in+polarized+epithelial+cells.+Role+in+apical+Ca%3Csup%3E2%2B%3C%2Fsup%3E+influx&rft.volume=280&rft.issue=13&rft.pages=12908-16&rft.date=2005&rft_id=info%3Adoi%2F10.1074%2Fjbc.M410013200&rft_id=info%3Apmid%2F15623527&rft.aulast=Bandyopadhyay&rft.aufirst=BC&rft.au=Swaim%2C+WD&rft.au=Liu%2C+X&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M410013200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKasriHolmesBultynck2004" class="citation journal cs1">Kasri NN, Holmes AM, Bultynck G, et al. (2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271747">"Regulation of InsP3 receptor activity by neuronal Ca<sup>2+</sup>-binding proteins"</a>. <i>EMBO J</i>. <b>23</b> (2): 312–21. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.emboj.7600037">10.1038/sj.emboj.7600037</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271747">1271747</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14685260">14685260</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=EMBO+J.&rft.atitle=Regulation+of+InsP3+receptor+activity+by+neuronal+Ca%3Csup%3E2%2B%3C%2Fsup%3E-binding+proteins&rft.volume=23&rft.issue=2&rft.pages=312-21&rft.date=2004&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1271747%23id-name%3DPMC&rft_id=info%3Apmid%2F14685260&rft_id=info%3Adoi%2F10.1038%2Fsj.emboj.7600037&rft.aulast=Kasri&rft.aufirst=NN&rft.au=Holmes%2C+AM&rft.au=Bultynck%2C+G&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1271747&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHattoriSuzukiHigo2004" class="citation journal cs1">Hattori M, Suzuki AZ, Higo T, et al. (2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M311456200">"Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca<sup>2+</sup> signaling"</a>. <i>J. Biol. Chem</i>. <b>279</b> (12): 11967–75. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M311456200">10.1074/jbc.M311456200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14707143">14707143</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Distinct+roles+of+inositol+1%2C4%2C5-trisphosphate+receptor+types+1+and+3+in+Ca%3Csup%3E2%2B%3C%2Fsup%3E+signaling&rft.volume=279&rft.issue=12&rft.pages=11967-75&rft.date=2004&rft_id=info%3Adoi%2F10.1074%2Fjbc.M311456200&rft_id=info%3Apmid%2F14707143&rft.aulast=Hattori&rft.aufirst=M&rft.au=Suzuki%2C+AZ&rft.au=Higo%2C+T&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M311456200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOlsenBlagoevGnad2006" class="citation journal cs1">Olsen JV, Blagoev B, Gnad F, et al. (2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2006.09.026">"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"</a>. <i>Cell</i>. <b>127</b> (3): 635–48. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2006.09.026">10.1016/j.cell.2006.09.026</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17081983">17081983</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:7827573">7827573</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Global%2C+in+vivo%2C+and+site-specific+phosphorylation+dynamics+in+signaling+networks&rft.volume=127&rft.issue=3&rft.pages=635-48&rft.date=2006&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A7827573%23id-name%3DS2CID&rft_id=info%3Apmid%2F17081983&rft_id=info%3Adoi%2F10.1016%2Fj.cell.2006.09.026&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev%2C+B&rft.au=Gnad%2C+F&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.cell.2006.09.026&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRoachDeutschLi2006" class="citation journal cs1">Roach JC, Deutsch K, Li S, et al. (2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592562">"Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden"</a>. <i>Am. J. Hum. Genet</i>. <b>79</b> (4): 614–27. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1086%2F507876">10.1086/507876</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592562">1592562</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16960798">16960798</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am.+J.+Hum.+Genet.&rft.atitle=Genetic+mapping+at+3-kilobase+resolution+reveals+inositol+1%2C4%2C5-triphosphate+receptor+3+as+a+risk+factor+for+type+1+diabetes+in+Sweden&rft.volume=79&rft.issue=4&rft.pages=614-27&rft.date=2006&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1592562%23id-name%3DPMC&rft_id=info%3Apmid%2F16960798&rft_id=info%3Adoi%2F10.1086%2F507876&rft.aulast=Roach&rft.aufirst=JC&rft.au=Deutsch%2C+K&rft.au=Li%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1592562&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTojyoMoritaNezuTanimura2008" class="citation journal cs1">Tojyo Y, Morita T, Nezu A, Tanimura A (2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1254%2Fjphs.08021FP">"The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca<sup>2+</sup> store"</a>. <i>J. Pharmacol. Sci</i>. <b>107</b> (2): 138–50. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1254%2Fjphs.08021FP">10.1254/jphs.08021FP</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18544901">18544901</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Pharmacol.+Sci.&rft.atitle=The+clustering+of+inositol+1%2C4%2C5-trisphosphate+%28IP%283%29%29+receptors+is+triggered+by+IP%283%29+binding+and+facilitated+by+depletion+of+the+Ca%3Csup%3E2%2B%3C%2Fsup%3E+store&rft.volume=107&rft.issue=2&rft.pages=138-50&rft.date=2008&rft_id=info%3Adoi%2F10.1254%2Fjphs.08021FP&rft_id=info%3Apmid%2F18544901&rft.aulast=Tojyo&rft.aufirst=Y&rft.au=Morita%2C+T&rft.au=Nezu%2C+A&rft.au=Tanimura%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1254%252Fjphs.08021FP&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSingletonBourguignon2004" class="citation journal cs1">Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca<sup>2+</sup> signaling leading to nitric oxide production and endothelial cell adhesion and proliferation". <i>Exp. Cell Res</i>. <b>295</b> (1): 102–18. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.yexcr.2003.12.025">10.1016/j.yexcr.2003.12.025</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15051494">15051494</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Exp.+Cell+Res.&rft.atitle=CD44+interaction+with+ankyrin+and+IP3+receptor+in+lipid+rafts+promotes+hyaluronan-mediated+Ca%3Csup%3E2%2B%3C%2Fsup%3E+signaling+leading+to+nitric+oxide+production+and+endothelial+cell+adhesion+and+proliferation&rft.volume=295&rft.issue=1&rft.pages=102-18&rft.date=2004&rft_id=info%3Adoi%2F10.1016%2Fj.yexcr.2003.12.025&rft_id=info%3Apmid%2F15051494&rft.aulast=Singleton&rft.aufirst=PA&rft.au=Bourguignon%2C+LY&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOtaSuzukiNishikawa2004" class="citation journal cs1">Ota T, Suzuki Y, Nishikawa T, et al. (2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fng1285">"Complete sequencing and characterization of 21,243 full-length human cDNAs"</a>. <i>Nat. Genet</i>. <b>36</b> (1): 40–5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fng1285">10.1038/ng1285</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14702039">14702039</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nat.+Genet.&rft.atitle=Complete+sequencing+and+characterization+of+21%2C243+full-length+human+cDNAs&rft.volume=36&rft.issue=1&rft.pages=40-5&rft.date=2004&rft_id=info%3Adoi%2F10.1038%2Fng1285&rft_id=info%3Apmid%2F14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki%2C+Y&rft.au=Nishikawa%2C+T&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fng1285&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOgasawara_H2008" class="citation journal cs1">Ogasawara H (2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670947">"The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection"</a>. <i>J. Neurosci</i>. <b>28</b> (17): 4293–4. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.0644-08.2008">10.1523/JNEUROSCI.0644-08.2008</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670947">6670947</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18434505">18434505</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Neurosci.&rft.atitle=The+calcium+kinetics+and+inositol+trisphosphate+receptor+properties+shape+the+asymmetric+timing+window+of+coincidence+detection&rft.volume=28&rft.issue=17&rft.pages=4293-4&rft.date=2008&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6670947%23id-name%3DPMC&rft_id=info%3Apmid%2F18434505&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.0644-08.2008&rft.au=Ogasawara+H&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6670947&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFQuMarchandSzymborski2008" class="citation journal cs1">Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II". <i>Genes Immun</i>. <b>9</b> (3): 264–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fgene.2008.12">10.1038/gene.2008.12</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18340361">18340361</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:8563179">8563179</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+Immun.&rft.atitle=The+association+between+type+1+diabetes+and+the+ITPR3+gene+polymorphism+due+to+linkage+disequilibrium+with+HLA+class+II&rft.volume=9&rft.issue=3&rft.pages=264-6&rft.date=2008&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A8563179%23id-name%3DS2CID&rft_id=info%3Apmid%2F18340361&rft_id=info%3Adoi%2F10.1038%2Fgene.2008.12&rft.aulast=Qu&rft.aufirst=HQ&rft.au=Marchand%2C+L&rft.au=Szymborski%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWuBowen2008" class="citation journal cs1">Wu Z, Bowen WD (2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661391">"Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells"</a>. <i>J. Biol. Chem</i>. <b>283</b> (42): 28198–215. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M802099200">10.1074/jbc.M802099200</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661391">2661391</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18539593">18539593</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Role+of+sigma-1+receptor+C-terminal+segment+in+inositol+1%2C4%2C5-trisphosphate+receptor+activation%3A+constitutive+enhancement+of+calcium+signaling+in+MCF-7+tumor+cells&rft.volume=283&rft.issue=42&rft.pages=28198-215&rft.date=2008&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2661391%23id-name%3DPMC&rft_id=info%3Apmid%2F18539593&rft_id=info%3Adoi%2F10.1074%2Fjbc.M802099200&rft.aulast=Wu&rft.aufirst=Z&rft.au=Bowen%2C+WD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2661391&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMartínez-GámezDent2007" class="citation journal cs1">Martínez-Gámez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve". <i>NeuroReport</i>. <b>18</b> (5): 447–50. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FWNR.0b013e32805868a6">10.1097/WNR.0b013e32805868a6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17496801">17496801</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:28136973">28136973</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=NeuroReport&rft.atitle=Expression+of+IP3+receptor+isoforms+at+the+nodes+of+Ranvier+in+rat+sciatic+nerve&rft.volume=18&rft.issue=5&rft.pages=447-50&rft.date=2007&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A28136973%23id-name%3DS2CID&rft_id=info%3Apmid%2F17496801&rft_id=info%3Adoi%2F10.1097%2FWNR.0b013e32805868a6&rft.aulast=Mart%C3%ADnez-G%C3%A1mez&rft.aufirst=A&rft.au=Dent%2C+MA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGarcia-EliasLorenzoVicenteValverde2008" class="citation journal cs1">Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.C800184200">"IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site"</a>. <i>J. Biol. Chem</i>. <b>283</b> (46): 31284–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.C800184200">10.1074/jbc.C800184200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18826956">18826956</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=IP3+receptor+binds+to+and+sensitizes+TRPV4+channel+to+osmotic+stimuli+via+a+calmodulin-binding+site&rft.volume=283&rft.issue=46&rft.pages=31284-8&rft.date=2008&rft_id=info%3Adoi%2F10.1074%2Fjbc.C800184200&rft_id=info%3Apmid%2F18826956&rft.aulast=Garcia-Elias&rft.aufirst=A&rft.au=Lorenzo%2C+IM&rft.au=Vicente%2C+R&rft.au=Valverde%2C+MA&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.C800184200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSundivakkamKwiatekSharma2009" class="citation journal cs1">Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660268">"Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca<sup>2+</sup> store release-induced Ca<sup>2+</sup> entry in endothelial cells"</a>. <i>Am. J. Physiol., Cell Physiol</i>. <b>296</b> (3): C403–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1152%2Fajpcell.00470.2008">10.1152/ajpcell.00470.2008</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660268">2660268</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19052258">19052258</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am.+J.+Physiol.%2C+Cell+Physiol.&rft.atitle=Caveolin-1+scaffold+domain+interacts+with+TRPC1+and+IP3R3+to+regulate+Ca%3Csup%3E2%2B%3C%2Fsup%3E+store+release-induced+Ca%3Csup%3E2%2B%3C%2Fsup%3E+entry+in+endothelial+cells&rft.volume=296&rft.issue=3&rft.pages=C403-13&rft.date=2009&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2660268%23id-name%3DPMC&rft_id=info%3Apmid%2F19052258&rft_id=info%3Adoi%2F10.1152%2Fajpcell.00470.2008&rft.aulast=Sundivakkam&rft.aufirst=PC&rft.au=Kwiatek%2C+AM&rft.au=Sharma%2C+TT&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2660268&rfr_id=info%3Asid%2Fen.wikipedia.org%3AITPR3" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ITPR3&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=ITPR3+protein%2C+human">ITPR3+protein,+human</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Membrane_transport_protein:_ion_channels_(TC_1A)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Ion_channels" title="Template:Ion channels"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Ion_channels" title="Template talk:Ion channels"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Ion_channels" title="Special:EditPage/Template:Ion channels"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Membrane_transport_protein:_ion_channels_(TC_1A)" style="font-size:114%;margin:0 4em"><a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">Membrane transport protein</a>: <a href="/wiki/Ion_channel" title="Ion channel">ion channels</a> (<a href="/wiki/Transporter_Classification_Database#1._Channels/Pores" title="Transporter Classification Database">TC 1A</a>)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="Ca2+:_Calcium_channel" style="font-size:114%;margin:0 4em"><i>Ca<sup>2+</sup>:</i> <a href="/wiki/Calcium_channel" title="Calcium channel">Calcium channel</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;">Ligand-gated</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Inositol_trisphosphate_receptor" title="Inositol trisphosphate receptor">Inositol trisphosphate receptor</a> <ul><li><a href="/wiki/ITPR1" title="ITPR1">1</a></li> <li><a href="/wiki/ITPR2" title="ITPR2">2</a></li> <li><a class="mw-selflink selflink">3</a></li></ul></li> <li><a href="/wiki/Ryanodine_receptor" title="Ryanodine receptor">Ryanodine receptor</a> <ul><li><a href="/wiki/RYR1" class="mw-redirect" title="RYR1">1</a></li> <li><a href="/wiki/Ryanodine_receptor_2" title="Ryanodine receptor 2">2</a></li> <li><a href="/wiki/RYR3" class="mw-redirect" title="RYR3">3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Voltage-gated_calcium_channel" title="Voltage-gated calcium channel">Voltage-gated</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L-type</a>/<i>Ca<sub>v</sub>α</i> <ul><li><a href="/wiki/Cav1.1" title="Cav1.1">1.1</a></li> <li><a href="/wiki/Cav1.2" title="Cav1.2">1.2</a></li> <li><a href="/wiki/Cav1.3" title="Cav1.3">1.3</a></li> <li><a href="/wiki/Cav1.4" title="Cav1.4">1.4</a></li></ul></li> <li><a href="/wiki/N-type_calcium_channel" title="N-type calcium channel">N-type</a>/<i>Ca<sub>v</sub>α2.2</i></li> <li><a href="/wiki/P-type_calcium_channel" title="P-type calcium channel">P-type</a>/<i>Ca<sub>v</sub>α</i> <ul><li><a href="/wiki/Cav2.1" title="Cav2.1">2.1</a></li></ul></li> <li><a href="/wiki/Q-type_calcium_channel" title="Q-type calcium channel">Q-type</a>/<i>Ca<sub>v</sub>α2.1</i></li> <li><a href="/wiki/R-type_calcium_channel" title="R-type calcium channel">R-type</a>/<i>Ca<sub>v</sub>α2.3</i></li> <li><a href="/wiki/T-type_calcium_channel" title="T-type calcium channel">T-type</a>/<i>Ca<sub>v</sub>α</i> <ul><li><a href="/wiki/CACNA1G" title="CACNA1G">3.1</a></li> <li><a href="/wiki/CACNA1H" class="mw-redirect" title="CACNA1H">3.2</a></li> <li><a href="/wiki/CACNA1I" title="CACNA1I">3.3</a></li></ul></li></ul> <ul><li><i>α<sub>2</sub>δ-subunits</i> <ul><li><a href="/wiki/CACNA2D1" title="CACNA2D1">1</a></li> <li><a href="/wiki/CACNA2D2" title="CACNA2D2">2</a></li></ul></li> <li><i>β-subunits</i> <ul><li><a href="/wiki/CACNB1" title="CACNB1">β1</a></li> <li><a href="/wiki/CACNB2" title="CACNB2">β2</a></li> <li><a href="/wiki/CACNB3" title="CACNB3">β3</a></li> <li><a href="/wiki/CACNB4" title="CACNB4">β4</a></li></ul></li> <li><i>γ-subunits</i> <ul><li><a href="/wiki/CACNG1" title="CACNG1">γ1</a></li> <li><a href="/wiki/CACNG2" title="CACNG2">γ2</a></li> <li><a href="/wiki/CACNG3" title="CACNG3">γ3</a></li> <li><a href="/wiki/CACNG4" title="CACNG4">γ4</a></li></ul></li></ul> <ul><li><a href="/wiki/Cation_channels_of_sperm" title="Cation channels of sperm">Cation channels of sperm</a> <ul><li><a href="/wiki/CatSper1" title="CatSper1">1</a></li> <li><a href="/wiki/CatSper2" title="CatSper2">2</a></li> <li><a href="/wiki/CatSper3" title="CatSper3">3</a></li> <li><a href="/wiki/CatSper4" title="CatSper4">4</a></li></ul></li> <li><a href="/wiki/Two-pore_channel" title="Two-pore channel">Two-pore channel</a> <ul><li><a href="/wiki/TPCN1" title="TPCN1">1</a></li> <li><a href="/wiki/TPCN2" title="TPCN2">2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="Na+:_Sodium_channel" style="font-size:114%;margin:0 4em"><i>Na<sup>+</sup>:</i> <a href="/wiki/Sodium_channel" title="Sodium channel">Sodium channel</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;">Constitutively active</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epithelial_sodium_channel" title="Epithelial sodium channel">Epithelial sodium channel</a> <ul><li><a href="/wiki/SCNN1A" title="SCNN1A">α</a></li> <li><a href="/wiki/SCNN1B" title="SCNN1B">β</a></li> <li><a href="/wiki/SCNN1G" title="SCNN1G">γ</a></li> <li><a href="/wiki/SCNN1D" title="SCNN1D">δ</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Hydron_(chemistry)" title="Hydron (chemistry)">Proton</a>-gated</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acid-sensing_ion_channel" title="Acid-sensing ion channel">Amiloride-sensitive cation channel</a> <ul><li><a href="/wiki/ACCN1" class="mw-redirect" title="ACCN1">1</a></li> <li><a href="/wiki/ACCN2" class="mw-redirect" title="ACCN2">2</a></li> <li><a href="/wiki/ACCN3" class="mw-redirect" title="ACCN3">3</a></li> <li><a href="/wiki/ACCN4" class="mw-redirect" title="ACCN4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Voltage-gated_sodium_channel" title="Voltage-gated sodium channel">Voltage-gated</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>Na<sub>v</sub>α</i> <ul><li><a href="/wiki/Nav1.1" class="mw-redirect" title="Nav1.1">1.1</a></li> <li><a href="/wiki/Nav1.2" class="mw-redirect" title="Nav1.2">1.2</a></li> <li><a href="/wiki/SCN3A" title="SCN3A">1.3</a></li> <li><a href="/wiki/Nav1.4" title="Nav1.4">1.4</a></li> <li><a href="/wiki/Nav1.5" class="mw-redirect" title="Nav1.5">1.5</a></li> <li><a href="/wiki/SCN8A" title="SCN8A">1.6</a></li> <li><a href="/wiki/Nav1.7" class="mw-redirect" title="Nav1.7">1.7</a></li> <li><a href="/wiki/SCN10A" class="mw-redirect" title="SCN10A">1.8</a></li> <li><a href="/wiki/Nav1.9" title="Nav1.9">1.9</a></li> <li><a href="/wiki/SCN7A" title="SCN7A">7A</a></li></ul></li> <li><i>Na<sub>v</sub>β</i> <ul><li><a href="/wiki/SCN1B" title="SCN1B">1</a></li> <li><a href="/wiki/SCN2B" title="SCN2B">2</a></li> <li><a href="/wiki/SCN3B" title="SCN3B">3</a></li> <li><a href="/wiki/SCN4B" title="SCN4B">4</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="K+:_Potassium_channel" style="font-size:114%;margin:0 4em"><i>K<sup>+</sup>:</i> <a href="/wiki/Potassium_channel" title="Potassium channel">Potassium channel</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Calcium-activated_potassium_channel" title="Calcium-activated potassium channel">Calcium-activated</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BK_channel" title="BK channel">BK channel</a> <ul><li><a href="/wiki/Calcium-activated_potassium_channel_subunit_alpha-1" title="Calcium-activated potassium channel subunit alpha-1">α1</a></li> <li><a href="/wiki/KCNMB1" title="KCNMB1">β1</a></li> <li><a href="/wiki/KCNMB2" title="KCNMB2">β2</a></li> <li><a href="/wiki/KCNMB3" title="KCNMB3">β3</a></li> <li><a href="/wiki/KCNMB4" title="KCNMB4">β4</a></li></ul></li> <li><a href="/wiki/SK_channel" title="SK channel">SK channel</a> <ul><li><a href="/wiki/KCNN1" title="KCNN1">SK1</a></li> <li><a href="/wiki/KCNN2" title="KCNN2">SK2</a></li> <li><a href="/wiki/SK3" title="SK3">SK3</a></li></ul></li> <li>IK channel <ul><li><a href="/wiki/KCNN4" title="KCNN4">IK1</a></li></ul></li> <li><i>K<sub>Ca</sub></i> <ul><li><a href="/wiki/Calcium-activated_potassium_channel_subunit_alpha-1" title="Calcium-activated potassium channel subunit alpha-1">1.1</a></li> <li><a href="/wiki/KCNN1" title="KCNN1">2.1</a></li> <li><a href="/wiki/KCNN2" title="KCNN2">2.2</a></li> <li><a href="/wiki/SK3" title="SK3">2.3</a></li> <li><a href="/wiki/KCNN4" title="KCNN4">3.1</a></li> <li><a href="/wiki/KCNT1" title="KCNT1">4.1</a></li> <li><a href="/wiki/KCNT2" title="KCNT2">4.2</a></li> <li><a href="/wiki/KCNU1" title="KCNU1">5.1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Inward-rectifier_potassium_ion_channel" class="mw-redirect" title="Inward-rectifier potassium ion channel">Inward-rectifier</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ATP-sensitive_potassium_channel" title="ATP-sensitive potassium channel">K<sub>ATP</sub></a></li> <li><i>K<sub>ir</sub></i> <ul><li><a href="/wiki/ROMK" title="ROMK">1.1</a></li> <li><a href="/wiki/Kir2.1" title="Kir2.1">2.1</a></li> <li><a href="/wiki/KCNJ12" title="KCNJ12">2.2</a></li> <li><a href="/wiki/KCNJ4" title="KCNJ4">2.3</a></li> <li><a href="/wiki/KCNJ14" title="KCNJ14">2.4</a></li> <li><a href="/wiki/Kir2.6" title="Kir2.6">2.6</a></li></ul></li> <li><a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel">GIRK</a>/<i>K<sub>ir</sub></i> <ul><li><a href="/wiki/KCNJ3" title="KCNJ3">3.1</a></li> <li><a href="/wiki/KCNJ6" title="KCNJ6">3.2</a></li> <li><a href="/wiki/KCNJ9" title="KCNJ9">3.3</a></li> <li><a href="/wiki/KCNJ5" title="KCNJ5">3.4</a></li></ul></li> <li><i>K<sub>ir</sub></i> <ul><li><a href="/wiki/KCNJ10" title="KCNJ10">4.1</a></li> <li><a href="/wiki/KCNJ15" title="KCNJ15">4.2</a></li> <li><a href="/wiki/KCNJ16" title="KCNJ16">5.1</a></li> <li><a href="/wiki/KCNJ8" title="KCNJ8">6.1</a></li> <li><a href="/wiki/Kir6.2" title="Kir6.2">6.2</a></li> <li><a href="/wiki/KCNJ13" title="KCNJ13">7.1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Tandem_pore_domain_potassium_channel" class="mw-redirect" title="Tandem pore domain potassium channel">Tandem pore domain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>K2P</i> <ul><li><a href="/wiki/KCNK1" title="KCNK1">1</a></li> <li><a href="/wiki/KCNK2" title="KCNK2">2</a></li> <li><a href="/wiki/KCNK3" title="KCNK3">3</a></li> <li><a href="/wiki/KCNK4" title="KCNK4">4</a></li> <li><a href="/wiki/KCNK5" title="KCNK5">5</a></li> <li><a href="/wiki/KCNK6" title="KCNK6">6</a></li> <li><a href="/wiki/KCNK7" title="KCNK7">7</a></li> <li><a href="/wiki/KCNK9" title="KCNK9">9</a></li> <li><a href="/wiki/KCNK10" title="KCNK10">10</a></li> <li><a href="/wiki/KCNK12" title="KCNK12">12</a></li> <li><a href="/wiki/KCNK13" title="KCNK13">13</a></li> <li><a href="/wiki/KCNK15" title="KCNK15">15</a></li> <li><a href="/wiki/KCNK16" title="KCNK16">16</a></li> <li><a href="/wiki/KCNK17" title="KCNK17">17</a></li> <li><a href="/wiki/KCNK18" title="KCNK18">18</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><a href="/wiki/Voltage-gated_potassium_channel" title="Voltage-gated potassium channel">Voltage-gated</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>K<sub>v</sub>α1-6</i> <ul><li><a href="/wiki/Kv1.1" title="Kv1.1">1.1</a></li> <li><a href="/wiki/KCNA2" title="KCNA2">1.2</a></li> <li><a href="/wiki/KCNA3" title="KCNA3">1.3</a></li> <li><a href="/wiki/KCNA4" title="KCNA4">1.4</a></li> <li><a href="/wiki/KCNA5" title="KCNA5">1.5</a></li> <li><a href="/wiki/KCNA6" title="KCNA6">1.6</a></li> <li><a href="/wiki/KCNA7" title="KCNA7">1.7</a></li> <li><a href="/wiki/KCNA10" title="KCNA10">1.8</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNB1" title="KCNB1">2.1</a></li> <li><a href="/wiki/KCNB2" title="KCNB2">2.2</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNC1" title="KCNC1">3.1</a></li> <li><a href="/wiki/KCNC2" title="KCNC2">3.2</a></li> <li><a href="/wiki/KCNC3" title="KCNC3">3.3</a></li> <li><a href="/wiki/KCNC4" title="KCNC4">3.4</a></li></ul></li> <li> <ul><li><a href="/wiki/KCND1" title="KCND1">4.1</a></li> <li><a href="/wiki/KCND2" title="KCND2">4.2</a></li> <li><a href="/wiki/KCND3" title="KCND3">4.3</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNF1" title="KCNF1">5.1</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNG1" title="KCNG1">6.1</a></li> <li><a href="/wiki/KCNG2" title="KCNG2">6.2</a></li> <li><a href="/wiki/KCNG3" title="KCNG3">6.3</a></li> <li><a href="/wiki/KCNG4" title="KCNG4">6.4</a></li></ul></li></ul> <ul><li><i>K<sub>v</sub>α7-12</i> <ul><li><a href="/wiki/KvLQT1" title="KvLQT1">7.1</a></li> <li><a href="/wiki/KvLQT2" title="KvLQT2">7.2</a></li> <li><a href="/wiki/KvLQT3" title="KvLQT3">7.3</a></li> <li><a href="/wiki/KCNQ4" title="KCNQ4">7.4</a></li> <li><a href="/wiki/KCNQ5" title="KCNQ5">7.5</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNV1" title="KCNV1">8.1</a></li> <li><a href="/wiki/KCNV2" title="KCNV2">8.2</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNS1" title="KCNS1">9.1</a></li> <li><a href="/wiki/KCNS2" title="KCNS2">9.2</a></li> <li><a href="/wiki/KCNS3" title="KCNS3">9.3</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNH1" title="KCNH1">10.1</a></li> <li><a href="/wiki/KCNH5" title="KCNH5">10.2</a></li></ul></li> <li> <ul><li><a href="/wiki/HERG" title="HERG">11.1/hERG</a></li> <li><a href="/wiki/KCNH6" title="KCNH6">11.2</a></li> <li><a href="/wiki/KCNH7" title="KCNH7">11.3</a></li></ul></li> <li> <ul><li><a href="/wiki/KCNH8" title="KCNH8">12.1</a></li> <li><a href="/wiki/KCNH3" title="KCNH3">12.2</a></li> <li><a href="/wiki/KCNH4" title="KCNH4">12.3</a></li></ul></li></ul> <ul><li><i>K<sub>v</sub>β</i> <ul><li><a href="/wiki/KCNAB1" title="KCNAB1">1</a></li> <li><a href="/wiki/KCNAB2" title="KCNAB2">2</a></li> <li><a href="/wiki/KCNAB3" title="KCNAB3">3</a></li></ul></li> <li><i>KCNIP</i> <ul><li><a href="/wiki/KCNIP1" title="KCNIP1">1</a></li> <li><a href="/wiki/KCNIP2" title="KCNIP2">2</a></li> <li><a href="/wiki/Calsenilin" title="Calsenilin">3</a></li> <li><a href="/wiki/KCNIP4" title="KCNIP4">4</a></li></ul></li> <li><a href="/wiki/KCNE1" title="KCNE1">minK/ISK</a></li> <li><a href="/wiki/KCNE1L" class="mw-redirect" title="KCNE1L">minK/ISK-like</a></li> <li><i>MiRP</i> <ul><li><a href="/wiki/KCNE2" title="KCNE2">1</a></li> <li><a href="/wiki/KCNE3" title="KCNE3">2</a></li> <li><a href="/wiki/KCNE4" title="KCNE4">3</a></li></ul></li> <li><a href="/wiki/Shaker_(gene)" title="Shaker (gene)">Shaker (gene)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="Miscellaneous" style="font-size:114%;margin:0 4em"><i>Miscellaneous</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Chloride" title="Chloride">Cl<sup>−</sup></a>:</i> <a href="/wiki/Chloride_channel" title="Chloride channel">Chloride channel</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcium-activated_chloride_channel" class="mw-redirect" title="Calcium-activated chloride channel">Calcium-activated chloride channels</a> <ul><li><i>Anoctamin</i> <ul><li><a href="/wiki/ANO1" title="ANO1">ANO1</a></li></ul></li> <li><i>Bestrophin</i> <ul><li><a href="/wiki/Bestrophin_1" title="Bestrophin 1">1</a></li> <li><a href="/wiki/BEST2" class="mw-redirect" title="BEST2">2</a></li></ul></li> <li><i>Chloride Channel Accessory</i> <ul><li><a href="/wiki/CLCA1" title="CLCA1">1</a></li> <li><a href="/wiki/CLCA2" title="CLCA2">2</a></li> <li><a href="/wiki/CLCA3" title="CLCA3">3</a></li> <li><a href="/wiki/CLCA4" title="CLCA4">4</a></li></ul></li></ul></li> <li><a href="/wiki/Cystic_fibrosis_transmembrane_conductance_regulator" title="Cystic fibrosis transmembrane conductance regulator">CFTR</a></li> <li><i>CLCN</i> <ul><li><a href="/wiki/CLCN1" title="CLCN1">1</a></li> <li><a href="/wiki/CLCN2" title="CLCN2">2</a></li> <li><a href="/wiki/CLCN3" title="CLCN3">3</a></li> <li><a href="/wiki/CLCN4" title="CLCN4">4</a></li> <li><a href="/wiki/CLCN5" title="CLCN5">5</a></li> <li><a href="/wiki/CLCN6" title="CLCN6">6</a></li> <li><a href="/wiki/CLCN7" title="CLCN7">7</a></li> <li><a href="/wiki/CLCNKA" title="CLCNKA">KA</a></li> <li><a href="/wiki/CLCNKB" title="CLCNKB">KB</a></li></ul></li> <li><i>CLIC</i> <ul><li><a href="/wiki/CLIC1" title="CLIC1">1</a></li> <li><a href="/wiki/CLIC2" title="CLIC2">2</a></li> <li><a href="/wiki/CLIC3" title="CLIC3">3</a></li> <li><a href="/wiki/CLIC4" title="CLIC4">4</a></li> <li><a href="/wiki/CLIC5" title="CLIC5">5</a></li> <li><a href="/wiki/CLIC6" title="CLIC6">6</a></li> <li><a href="/wiki/CLCC1" title="CLCC1">L1</a></li></ul></li> <li><i>CLNS</i> <ul><li><a href="/wiki/CLNS1A" title="CLNS1A">1A</a></li> <li><a href="/wiki/CLNS1B" title="CLNS1B">1B</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Hydron_(chemistry)" title="Hydron (chemistry)">H<sup>+</sup></a>:</i> <a href="/wiki/Voltage-gated_proton_channel" title="Voltage-gated proton channel">Proton channel</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HVCN1" title="HVCN1">HVCN1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Ion#Anions_and_cations" title="Ion">M<sup>+</sup></a>:</i> <a href="/wiki/Cyclic_nucleotide-gated_ion_channel" class="mw-redirect" title="Cyclic nucleotide-gated ion channel">CNG cation channel</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>α</i> <ul><li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_1" title="Cyclic nucleotide-gated channel alpha 1">1</a></li> <li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_2" title="Cyclic nucleotide-gated channel alpha 2">2</a></li> <li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_3" title="Cyclic nucleotide-gated channel alpha 3">3</a></li> <li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_4" title="Cyclic nucleotide-gated channel alpha 4">4</a></li></ul></li> <li><i>β</i> <ul><li><a href="/wiki/CNGB1" title="CNGB1">1</a></li> <li><a href="/wiki/Cyclic_nucleotide-gated_channel_alpha_4" title="Cyclic nucleotide-gated channel alpha 4">2</a></li> <li><a href="/wiki/Cyclic_nucleotide_gated_channel_beta_3" title="Cyclic nucleotide gated channel beta 3">3</a></li></ul></li> <li><i><a href="/wiki/HCN_channel" title="HCN channel">HCN</a></i> <ul><li><a href="/wiki/Funny_current" class="mw-redirect" title="Funny current">FC</a></li> <li><a href="/wiki/HCN1" title="HCN1">1</a></li> <li><a href="/wiki/HCN2" title="HCN2">2</a></li> <li><a href="/wiki/HCN3" title="HCN3">3</a></li> <li><a href="/wiki/HCN4" title="HCN4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Ion#Anions_and_cations" title="Ion">M<sup>+</sup></a>:</i> <a href="/wiki/Transient_receptor_potential_channel" title="Transient receptor potential channel">TRP cation channel</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TRPA_(channel)" class="mw-redirect" title="TRPA (channel)">TRPA</a> (<a href="/wiki/Transient_receptor_potential_cation_channel,_member_A1" class="mw-redirect" title="Transient receptor potential cation channel, member A1">1</a>)</li> <li><a href="/wiki/TRPC" title="TRPC">TRPC</a> <ul><li><a href="/wiki/TRPC1" title="TRPC1">1</a></li> <li><a href="/wiki/TRPC2" title="TRPC2">2</a></li> <li><a href="/wiki/TRPC3" title="TRPC3">3</a></li> <li><a href="/wiki/TRPC4" title="TRPC4">4</a></li> <li><a href="/wiki/TRPC4AP" title="TRPC4AP">4AP</a></li> <li><a href="/wiki/TRPC5" title="TRPC5">5</a></li> <li><a href="/wiki/TRPC6" title="TRPC6">6</a></li> <li><a href="/wiki/TRPC7" title="TRPC7">7</a></li></ul></li> <li><a href="/wiki/TRPM" title="TRPM">TRPM</a> <ul><li><a href="/wiki/TRPM1" title="TRPM1">1</a></li> <li><a href="/wiki/TRPM2" title="TRPM2">2</a></li> <li><a href="/wiki/TRPM3" title="TRPM3">3</a></li> <li><a href="/wiki/TRPM4" title="TRPM4">4</a></li> <li><a href="/wiki/TRPM5" title="TRPM5">5</a></li> <li><a href="/wiki/TRPM6" title="TRPM6">6</a></li> <li><a href="/wiki/TRPM7" title="TRPM7">7</a></li> <li><a href="/wiki/TRPM8" title="TRPM8">8</a></li></ul></li> <li><a href="/wiki/TRPML" title="TRPML">TRPML</a> <ul><li><a href="/wiki/Mucolipin-1" class="mw-redirect" title="Mucolipin-1">1</a></li> <li><a href="/wiki/MCOLN2" title="MCOLN2">2</a></li> <li><a href="/wiki/MCOLN3" title="MCOLN3">3</a></li></ul></li> <li><a href="/wiki/TRPN" title="TRPN">TRPN</a></li> <li><a href="/wiki/TRPP" title="TRPP">TRPP</a> <ul><li><a href="/wiki/PKD1" class="mw-redirect" title="PKD1">1</a></li> <li><a href="/wiki/Polycystic_kidney_disease_2" class="mw-redirect" title="Polycystic kidney disease 2">2</a></li></ul></li> <li><a href="/wiki/TRPV" title="TRPV">TRPV</a> <ul><li><a href="/wiki/TRPV1" title="TRPV1">1</a></li> <li><a href="/wiki/TRPV2" title="TRPV2">2</a></li> <li><a href="/wiki/TRPV3" title="TRPV3">3</a></li> <li><a href="/wiki/TRPV4" title="TRPV4">4</a></li> <li><a href="/wiki/TRPV5" title="TRPV5">5</a></li> <li><a href="/wiki/TRPV6" title="TRPV6">6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Water" title="Water">H<sub>2</sub>O</a> (+ <a href="/wiki/Solutes" class="mw-redirect" title="Solutes">solutes</a>):</i> <a href="/wiki/Porin_(protein)" title="Porin (protein)">Porin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aquaporin" title="Aquaporin">Aquaporin</a> <ul><li><a href="/wiki/MIP_(gene)" class="mw-redirect" title="MIP (gene)">0</a></li> <li><a href="/wiki/Aquaporin_1" class="mw-redirect" title="Aquaporin 1">1</a></li> <li><a href="/wiki/Aquaporin_2" class="mw-redirect" title="Aquaporin 2">2</a></li> <li><a href="/wiki/Aquaporin_3" class="mw-redirect" title="Aquaporin 3">3</a></li> <li><a href="/wiki/Aquaporin_4" class="mw-redirect" title="Aquaporin 4">4</a></li> <li><a href="/wiki/AQP5" class="mw-redirect" title="AQP5">5</a></li> <li><a href="/wiki/AQP6" class="mw-redirect" title="AQP6">6</a></li> <li><a href="/wiki/AQP7" class="mw-redirect" title="AQP7">7</a></li> <li><a href="/wiki/AQP8" class="mw-redirect" title="AQP8">8</a></li> <li><a href="/wiki/AQP9" class="mw-redirect" title="AQP9">9</a></li></ul></li> <li><a href="/wiki/Voltage-dependent_anion_channel" title="Voltage-dependent anion channel">Voltage-dependent anion channel</a> <ul><li><a href="/wiki/VDAC1" title="VDAC1">1</a></li> <li><a href="/wiki/VDAC2" title="VDAC2">2</a></li> <li><a href="/wiki/VDAC3" title="VDAC3">3</a></li></ul></li> <li><a href="/wiki/General_bacterial_porin_family" title="General bacterial porin family">General bacterial porin family</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:15em;text-align:left;"><i><a href="/wiki/Cytoplasm" title="Cytoplasm">Cytoplasm</a>:</i> <a href="/wiki/Gap_junction" title="Gap junction">Gap junction</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Connexin" title="Connexin">Connexin</a> <ul><li>A <ul><li><a href="/wiki/GJA1" title="GJA1">GJA1</a></li> <li><a href="/wiki/GJA3" title="GJA3">GJA3</a></li> <li><a href="/wiki/GJA4" title="GJA4">GJA4</a></li> <li><a href="/wiki/GJA5" title="GJA5">GJA5</a></li> <li><a href="/wiki/GJA8" title="GJA8">GJA8</a></li> <li><a href="/wiki/GJD2" title="GJD2">GJA9</a></li> <li><a href="/wiki/GJA10" title="GJA10">GJA10</a></li></ul></li> <li>B <ul><li><a href="/wiki/GJB1" title="GJB1">GJB1</a></li> <li><a href="/wiki/GJB2" title="GJB2">GJB2</a></li> <li><a href="/wiki/GJB3" title="GJB3">GJB3</a></li> <li><a href="/wiki/GJB4" title="GJB4">GJB4</a></li> <li><a href="/wiki/GJB5" title="GJB5">GJB5</a></li> <li><a href="/wiki/GJB6" title="GJB6">GJB6</a></li> <li><a href="/wiki/GJB7" title="GJB7">GJB7</a></li></ul></li> <li>C <ul><li><a href="/wiki/GJC1" title="GJC1">GJC1</a></li> <li><a href="/wiki/GJC2" title="GJC2">GJC2</a></li> <li><a href="/wiki/GJC3" title="GJC3">GJC3</a></li></ul></li> <li>D <ul><li><a href="/wiki/GJD2" title="GJD2">GJD2</a></li> <li><a href="/wiki/GJD3" title="GJD3">GJD3</a></li> <li><a href="/wiki/GJD4" title="GJD4">GJD4</a></li></ul></li></ul></li> <li><a href="/wiki/Innexin" title="Innexin">Innexin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="By_gating_mechanism" style="font-size:114%;margin:0 4em"><i>By gating mechanism</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Ion_channel_class" scope="row" class="navbox-group" style="width:15em;text-align:left;"><i>Ion channel class</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ligand-gated_ion_channel" title="Ligand-gated ion channel">Ligand-gated</a></li> <li><a href="/wiki/Light-gated_ion_channel" title="Light-gated ion channel">Light-gated</a></li> <li><a href="/wiki/Voltage-gated_ion_channel" title="Voltage-gated ion channel">Voltage-gated</a></li> <li><a href="/wiki/Stretch-activated_ion_channel" class="mw-redirect" title="Stretch-activated ion channel">Stretch-activated</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite; padding: 0px;"><div><i>see also <a href="/wiki/Template:Channelopathy" title="Template:Channelopathy">disorders</a></i></div></td></tr></tbody></table></div> <p><br /> </p> <style data-mw-deduplicate="TemplateStyles:r1012311289">.mw-parser-output .asbox{position:relative;overflow:hidden}.mw-parser-output .asbox table{background:transparent}.mw-parser-output .asbox p{margin:0}.mw-parser-output .asbox p+p{margin-top:0.25em}.mw-parser-output .asbox-body{font-style:italic}.mw-parser-output .asbox-note{font-size:smaller}.mw-parser-output .asbox .navbar{position:absolute;top:-0.75em;right:1em;display:none}</style><div role="note" class="metadata plainlinks asbox stub"><table role="presentation"><tbody><tr class="noresize"><td><span typeof="mw:File"><a href="/wiki/File:Beta-2_adrenergic_receptor.png" class="mw-file-description"><img alt="Stub icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Beta-2_adrenergic_receptor.png/30px-Beta-2_adrenergic_receptor.png" decoding="async" width="30" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Beta-2_adrenergic_receptor.png/45px-Beta-2_adrenergic_receptor.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Beta-2_adrenergic_receptor.png/60px-Beta-2_adrenergic_receptor.png 2x" data-file-width="702" data-file-height="933" /></a></span></td><td><p class="asbox-body">This <a href="/wiki/Membrane_protein" title="Membrane protein">membrane protein</a>–related article is a <a href="/wiki/Wikipedia:Stub" title="Wikipedia:Stub">stub</a>. You can help Wikipedia by <a class="external text" href="https://en.wikipedia.org/w/index.php?title=ITPR3&action=edit">expanding it</a>.</p></td></tr></tbody></table><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Membrane-protein-stub" title="Template:Membrane-protein-stub"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Membrane-protein-stub" title="Template talk:Membrane-protein-stub"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Membrane-protein-stub" title="Special:EditPage/Template:Membrane-protein-stub"><abbr title="Edit this template">e</abbr></a></li></ul></div></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=ITPR3&oldid=1196420604">https://en.wikipedia.org/w/index.php?title=ITPR3&oldid=1196420604</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_6" title="Category:Genes on human chromosome 6">Genes on human chromosome 6</a></li><li><a href="/wiki/Category:Ion_channels" title="Category:Ion channels">Ion channels</a></li><li><a href="/wiki/Category:Membrane_protein_stubs" title="Category:Membrane protein stubs">Membrane protein stubs</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_matches_Wikidata" title="Category:Short description matches Wikidata">Short description matches Wikidata</a></li><li><a href="/wiki/Category:All_stub_articles" title="Category:All stub articles">All stub articles</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 17 January 2024, at 11:39<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. By using this site, you agree to the <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use" class="extiw" title="foundation:Special:MyLanguage/Policy:Terms of Use">Terms of Use</a> and <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy" class="extiw" title="foundation:Special:MyLanguage/Policy:Privacy policy">Privacy Policy</a>. Wikipedia® is a registered trademark of the <a rel="nofollow" class="external text" href="https://wikimediafoundation.org/">Wikimedia Foundation, Inc.</a>, a non-profit organization.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Privacy policy</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:About">About Wikipedia</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:General_disclaimer">Disclaimers</a></li> <li id="footer-places-contact"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us">Contact Wikipedia</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Code of Conduct</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Developers</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/en.wikipedia.org">Statistics</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Cookie statement</a></li> <li id="footer-places-mobileview"><a href="//en.m.wikipedia.org/w/index.php?title=ITPR3&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobile view</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.canary-84779d6bf6-crlgt","wgBackendResponseTime":162,"wgPageParseReport":{"limitreport":{"cputime":"0.779","walltime":"1.523","ppvisitednodes":{"value":1782,"limit":1000000},"postexpandincludesize":{"value":172021,"limit":2097152},"templateargumentsize":{"value":650,"limit":2097152},"expansiondepth":{"value":8,"limit":100},"expensivefunctioncount":{"value":57,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":77642,"limit":5000000},"entityaccesscount":{"value":57,"limit":400},"timingprofile":["100.00% 1057.665 1 -total"," 65.94% 697.399 1 Template:Infobox_gene"," 12.52% 132.451 1 Template:Ion_channels"," 12.19% 128.909 1 Template:Navbox_with_collapsible_groups"," 8.68% 91.808 22 Template:Cite_journal"," 6.29% 66.517 1 Template:Short_description"," 3.49% 36.890 2 Template:Pagetype"," 2.69% 28.479 1 Template:Reflist"," 1.91% 20.252 1 Template:Membrane-protein-stub"," 1.81% 19.128 3 Template:Main_other"]},"scribunto":{"limitreport-timeusage":{"value":"0.593","limit":"10.000"},"limitreport-memusage":{"value":9753066,"limit":52428800}},"cachereport":{"origin":"mw-web.eqiad.main-5dc468848-xfbrr","timestamp":"20241122163714","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"ITPR3","url":"https:\/\/en.wikipedia.org\/wiki\/ITPR3","sameAs":"http:\/\/www.wikidata.org\/entity\/Q18028078","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q18028078","author":{"@type":"Organization","name":"Contributors to Wikimedia projects"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2008-07-13T12:46:57Z","dateModified":"2024-01-17T11:39:39Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/3\/3c\/IP3_receptor_type_3_%28ITPR3%29_-_6DQN.png","headline":"protein-coding gene in the species Homo sapiens"}</script> </body> </html>