CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Semmelweis University | Molecular Medicine Research Group - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "departments", 'action': "show_works", 'controller_action': 'departments#show_works', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="ybyLUuu3qVI1ovF9wHeHwYpV5K+hmnrkeMu+aKkvrrXk0HMYXi4338vTRKUkiN/B/KsrFcYhbwaJyvFp+djTpw==" /> <link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="description" content="Academia.edu is the platform to share, find, and explore 50 Million research papers. Join us to accelerate your research needs & academic interests." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'departments'; var $action_name = "show_works"; var $rails_env = 'production'; var $app_rev = 'b67ef4c3c1ecbe370843942feb5e75d02a3437b4'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15276,"monthly_visitors":"113 million","monthly_visitor_count":113784677,"monthly_visitor_count_in_millions":113,"user_count":277507088,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1732765799000); window.Aedu.timeDifference = new Date().getTime() - 1732765799000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-bdb9e8c097f01e611f2fc5e2f1a9dc599beede975e2ae5629983543a1726e947.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-7734a8b54dedb8fefe75ef934203d0ef41d066c1c5cfa6ba2a13dd7ec8bce449.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-33f19fd043c8c49f63805d0288e3f2d1d21ba0d2e162ab59bb7c183e51000368.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://sote.academia.edu/Departments/Molecular_Medicine_Research_Group/Documents" /> </head>   <body class='c-departments a-show_works logged_out u-bgColorWhite'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav no-xs no-sm no-md"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <div class="DesignSystem" style="margin-top:-40px"><div class="PageHeader"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><div class="u-floatLeft u-fs24 u-tcGrayDarkest"><span class="PageHeader-title u-m0x u-fw700 u-mr5x u-pr5x u-borderColorGrayLight u-borderRight1"><a href="https://sote.academia.edu/"><span class="u-linkUnstyled u-tcGrayDarkest">Semmelweis University</span></a></span><h1 class="u-m0x u-fw300 u-fs24 u-displayInline">Molecular Medicine Research Group</h1></div><div class="u-floatRight u-mt1x"></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline"><li class="u-floatLeft u-pr5x u-mr5x u-borderColorGrayLight u-borderRight1"><a href="https://sote.academia.edu/"><span><i class="fa fa-arrow-left"></i>  All Departments</span></a></li><li class="u-floatLeft active"><a href="https://sote.academia.edu/Departments/Molecular_Medicine_Research_Group/Documents">11 Papers</a></li><li class="u-floatLeft"><a href="https://sote.academia.edu/Departments/Molecular_Medicine_Research_Group">1 Researchers</a></li></ul></div></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="u-ph0x"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24511069 coauthored" data-work_id="24511069" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24511069/Common_Genetic_Variants_of_the_Human_Steroid_21_Hydroxylase_Gene_CYP21A2_Are_Related_to_Differences_in_Circulating_Hormone_Levels">Common Genetic Variants of the Human Steroid 21- Hydroxylase Gene (CYP21A2) Are Related to Differences in Circulating Hormone Levels</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose: Systematic evaluation of the potential relationship between the common genetic variants of CYP21A2 and hormone levels. Methods: The relationships of CYP21A2 intron 2 polymorphisms and haplotypes with diverse baseline and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24511069" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose: Systematic evaluation of the potential relationship between the common genetic variants of CYP21A2 and hormone levels. Methods: The relationships of CYP21A2 intron 2 polymorphisms and haplotypes with diverse baseline and stimulated blood hormone levels were studied in 106 subjects with non-functioning adrenal incidentaloma (NFAI). The rationale for using NFAI subjects is dual: i) their baseline hormone profiles do not differ from those of healthy subjects and ii) hormone levels after stimulation tests are available. Results: The carriers (N = 27) of a well-defined CYP21A2 haplotype cluster (c5) had significantly elevated levels of cortisol (p = 0.0110), and 17-hydroxyprogesterone (p = 0.0001) after ACTH stimulation, and 11-deoxycortisol after metyrapone administration (p = 0.0017), but the hormone values were in normal ranges. In addition, the carriers (N = 33) of the C allele of the rs6462 polymorphism had a higher baseline aldosterone level (p = 0.0006). The prevalence of these genetic variants of CYP21A2 did not differ between NFAI and healthy subjects. Conclusions: The common CYP21A2 variants presumably exert the same effect on hormone levels in the healthy and disease-affected populations. Therefore, they may contribute to complex diseases such as some cardiovascular diseases, and may influence the genotype-phenotype correlation in patients with congenital adrenal hyperplasia (CAH) including the individual need for hormone substitution.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24511069" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="51370109d3b4fbb421d40274591bca5f" rel="nofollow" data-download="{"attachment_id":44843265,"asset_id":24511069,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44843265/download_file?st=MTczMjc2NTc5OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-24511069">+1</span><div class="hidden js-additional-users-24511069"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://sote.academia.edu/KlaraKoncz">Klara Koncz</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-24511069'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-24511069').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_24511069 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24511069"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24511069, container: ".js-paper-rank-work_24511069", }); });</script></li><li class="js-percentile-work_24511069 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24511069; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24511069"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24511069 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24511069"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24511069; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24511069]").text(description); $(".js-view-count-work_24511069").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24511069").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24511069"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1135" href="https://www.academia.edu/Documents/in/Human_Genetics">Human Genetics</a>, <script data-card-contents-for-ri="1135" type="text/json">{"id":1135,"name":"Human Genetics","url":"https://www.academia.edu/Documents/in/Human_Genetics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24856" href="https://www.academia.edu/Documents/in/STEROIDS">STEROIDS</a>, <script data-card-contents-for-ri="24856" type="text/json">{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="74235" href="https://www.academia.edu/Documents/in/Copy_Number_Variation_of_DNA">Copy Number Variation of DNA</a>, <script data-card-contents-for-ri="74235" type="text/json">{"id":74235,"name":"Copy Number Variation of DNA","url":"https://www.academia.edu/Documents/in/Copy_Number_Variation_of_DNA","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="589853" href="https://www.academia.edu/Documents/in/Adrenal_Gland">Adrenal Gland</a><script data-card-contents-for-ri="589853" type="text/json">{"id":589853,"name":"Adrenal Gland","url":"https://www.academia.edu/Documents/in/Adrenal_Gland","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24511069]'), work: {"id":24511069,"title":"Common Genetic Variants of the Human Steroid 21- Hydroxylase Gene (CYP21A2) Are Related to Differences in Circulating Hormone Levels","created_at":"2016-04-18T00:23:36.897-07:00","owner_id":46696509,"url":"https://www.academia.edu/24511069/Common_Genetic_Variants_of_the_Human_Steroid_21_Hydroxylase_Gene_CYP21A2_Are_Related_to_Differences_in_Circulating_Hormone_Levels","slug":"Common_Genetic_Variants_of_the_Human_Steroid_21_Hydroxylase_Gene_CYP21A2_Are_Related_to_Differences_in_Circulating_Hormone_Levels","dom_id":"work_24511069","summary":"Purpose: Systematic evaluation of the potential relationship between the common genetic variants of CYP21A2 and hormone levels. Methods: The relationships of CYP21A2 intron 2 polymorphisms and haplotypes with diverse baseline and stimulated blood hormone levels were studied in 106 subjects with non-functioning adrenal incidentaloma (NFAI). The rationale for using NFAI subjects is dual: i) their baseline hormone profiles do not differ from those of healthy subjects and ii) hormone levels after stimulation tests are available. Results: The carriers (N = 27) of a well-defined CYP21A2 haplotype cluster (c5) had significantly elevated levels of cortisol (p = 0.0110), and 17-hydroxyprogesterone (p = 0.0001) after ACTH stimulation, and 11-deoxycortisol after metyrapone administration (p = 0.0017), but the hormone values were in normal ranges. In addition, the carriers (N = 33) of the C allele of the rs6462 polymorphism had a higher baseline aldosterone level (p = 0.0006). The prevalence of these genetic variants of CYP21A2 did not differ between NFAI and healthy subjects. Conclusions: The common CYP21A2 variants presumably exert the same effect on hormone levels in the healthy and disease-affected populations. Therefore, they may contribute to complex diseases such as some cardiovascular diseases, and may influence the genotype-phenotype correlation in patients with congenital adrenal hyperplasia (CAH) including the individual need for hormone substitution.","publication":null,"publication_with_fallback":"PLOS ONE","downloadable_attachments":[{"id":44843265,"asset_id":24511069,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44843265/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44843265/CYP21A2_incidentaloma_Doleschall__2014-libre.pdf?1460963345=\u0026response-content-disposition=attachment%3B+filename%3DCommon_Genetic_Variants_of_the_Human_Ste.pdf\u0026Expires=1732766622\u0026Signature=YUgwaaqRdItm7neOZh4JOcU~0-5TW7a2wiDDG8dCw9an5Ak~DjTJKthwlk~DLLYEeRStxsbu~lT8WpX5hzC-9ThIeP2xYOVhIf~X3KY1n1GsvBnx~nVCadZ5ti1HtB~wz4nYQYpGe3qVNn4PzYg0TLIDIE~wBXK7l0foULsCb7~NnXhCvJhLr-q1c-cGQqdg-P3kolM4R7crVR-GlK3vl7hf32spWwAos9Xpdcd6v5IFkZqeeaYCikPe6xgfXJ4uXU8Dv8J2ie7baP~4~bunWYDQNSH6kIWYmOEGOT1V0sTgbvrKDiPD9iVjSQ7FQpJH1X4wbUDrmQOZhbHyIuez2g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44843265/download_file?st=MTczMjc2NTc5OCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44843265/mini_magick20220704-26657-lttrdb.png?1656938725"}],"downloadable_attachments_with_full_thumbnails":[{"id":44843265,"asset_id":24511069,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44843265/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44843265/CYP21A2_incidentaloma_Doleschall__2014-libre.pdf?1460963345=\u0026response-content-disposition=attachment%3B+filename%3DCommon_Genetic_Variants_of_the_Human_Ste.pdf\u0026Expires=1732766622\u0026Signature=YUgwaaqRdItm7neOZh4JOcU~0-5TW7a2wiDDG8dCw9an5Ak~DjTJKthwlk~DLLYEeRStxsbu~lT8WpX5hzC-9ThIeP2xYOVhIf~X3KY1n1GsvBnx~nVCadZ5ti1HtB~wz4nYQYpGe3qVNn4PzYg0TLIDIE~wBXK7l0foULsCb7~NnXhCvJhLr-q1c-cGQqdg-P3kolM4R7crVR-GlK3vl7hf32spWwAos9Xpdcd6v5IFkZqeeaYCikPe6xgfXJ4uXU8Dv8J2ie7baP~4~bunWYDQNSH6kIWYmOEGOT1V0sTgbvrKDiPD9iVjSQ7FQpJH1X4wbUDrmQOZhbHyIuez2g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44843265/download_file?st=MTczMjc2NTc5OCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44843265/mini_magick20220704-26657-lttrdb.png?1656938725"}],"has_pdf":true,"has_fulltext":true,"page_count":10,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"},{"id":47491285,"first_name":"Klara","last_name":"Koncz","domain_name":"sote","page_name":"KlaraKoncz","display_name":"Klara Koncz","profile_url":"https://sote.academia.edu/KlaraKoncz","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1135,"name":"Human Genetics","url":"https://www.academia.edu/Documents/in/Human_Genetics","nofollow":false},{"id":24856,"name":"STEROIDS","url":"https://www.academia.edu/Documents/in/STEROIDS","nofollow":false},{"id":74235,"name":"Copy Number Variation of DNA","url":"https://www.academia.edu/Documents/in/Copy_Number_Variation_of_DNA","nofollow":false},{"id":589853,"name":"Adrenal Gland","url":"https://www.academia.edu/Documents/in/Adrenal_Gland","nofollow":false},{"id":1399723,"name":"Steroid","url":"https://www.academia.edu/Documents/in/Steroid"}],"publication_year":null,"publication_year_with_fallback":2014,"paper_rank":null,"all_time_views":22,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24554752" data-work_id="24554752" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24554752/Intraspecific_Evolution_of_Human_RCCX_Copy_Number_Variation_Traced_by_Haplotypes_of_the_CYP21A2_Gene">Intraspecific Evolution of Human RCCX Copy Number Variation Traced by Haplotypes of the CYP21A2 Gene</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The RCCX region is a complex, multiallelic, tandem copy number variation (CNV). Two complete genes, complement component 4 (C4) and steroid 21-hydroxylase (CYP21A2, formerly CYP21B), reside in its variable region. RCCX is prone to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24554752" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The RCCX region is a complex, multiallelic, tandem copy number variation (CNV). Two complete genes, complement component 4 (C4) and steroid 21-hydroxylase (CYP21A2, formerly CYP21B), reside in its variable region. RCCX is prone to nonallelic homologous recombination (NAHR) such as unequal crossover, generating duplications and deletions of RCCX modules, and gene conversion. A series of allele-specific long-range polymerase chain reaction coupled to the whole-gene sequencing of CYP21A2 was developed for molecular haplotyping. By means of the developed techniques, 35 different kinds of CYP21A2 haplotype variant were experimentally determined from 112 unrelated European subjects. The number of the resolved CYP21A2 haplotype variants was increased to 61 by bioinformatic haplotype reconstruction. The CYP21A2 haplotype variants could be assigned to the haplotypic RCCX CNV structures (the copy number of RCCX modules) in most cases. The genealogy network constructed from the CYP21A2 haplotype variants delineated the origin of RCCX structures. The different RCCX structures were located in tight groups. The minority of groups with identical RCCX structure occurred once in the network, implying monophyletic origin, but the majority of groups occurred several times and in different locations, indicating polyphyletic origin. The monophyletic groups were often created by single unequal crossover, whereas recurrent unequal crossover events generated some of the polyphyletic groups. As a result of recurrent NAHR events, more CYP21A2 haplotype variants with different allele patterns belonged to the same RCCX structure. The intraspecific evolution of RCCX CNV described here has provided a reasonable expectation for that of complex, multiallelic, tandem CNVs in humans.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24554752" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fd83579278e54b73b7979089a964dda6" rel="nofollow" data-download="{"attachment_id":44884827,"asset_id":24554752,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44884827/download_file?st=MTczMjc2NTc5OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24554752 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24554752"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24554752, container: ".js-paper-rank-work_24554752", }); });</script></li><li class="js-percentile-work_24554752 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24554752; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24554752"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24554752 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24554752"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24554752; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24554752]").text(description); $(".js-view-count-work_24554752").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24554752").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24554752"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="155" href="https://www.academia.edu/Documents/in/Evolutionary_Biology">Evolutionary Biology</a>, <script data-card-contents-for-ri="155" type="text/json">{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1135" href="https://www.academia.edu/Documents/in/Human_Genetics">Human Genetics</a>, <script data-card-contents-for-ri="1135" type="text/json">{"id":1135,"name":"Human Genetics","url":"https://www.academia.edu/Documents/in/Human_Genetics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="74235" href="https://www.academia.edu/Documents/in/Copy_Number_Variation_of_DNA">Copy Number Variation of DNA</a><script data-card-contents-for-ri="74235" type="text/json">{"id":74235,"name":"Copy Number Variation of DNA","url":"https://www.academia.edu/Documents/in/Copy_Number_Variation_of_DNA","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24554752]'), work: {"id":24554752,"title":"Intraspecific Evolution of Human RCCX Copy Number Variation Traced by Haplotypes of the CYP21A2 Gene","created_at":"2016-04-19T04:34:36.442-07:00","owner_id":46696509,"url":"https://www.academia.edu/24554752/Intraspecific_Evolution_of_Human_RCCX_Copy_Number_Variation_Traced_by_Haplotypes_of_the_CYP21A2_Gene","slug":"Intraspecific_Evolution_of_Human_RCCX_Copy_Number_Variation_Traced_by_Haplotypes_of_the_CYP21A2_Gene","dom_id":"work_24554752","summary":"The RCCX region is a complex, multiallelic, tandem copy number variation (CNV). Two complete genes, complement component 4 (C4) and steroid 21-hydroxylase (CYP21A2, formerly CYP21B), reside in its variable region. RCCX is prone to nonallelic homologous recombination (NAHR) such as unequal crossover, generating duplications and deletions of RCCX modules, and gene conversion. A series of allele-specific long-range polymerase chain reaction coupled to the whole-gene sequencing of CYP21A2 was developed for molecular haplotyping. By means of the developed techniques, 35 different kinds of CYP21A2 haplotype variant were experimentally determined from 112 unrelated European subjects. The number of the resolved CYP21A2 haplotype variants was increased to 61 by bioinformatic haplotype reconstruction. The CYP21A2 haplotype variants could be assigned to the haplotypic RCCX CNV structures (the copy number of RCCX modules) in most cases. The genealogy network constructed from the CYP21A2 haplotype variants delineated the origin of RCCX structures. The different RCCX structures were located in tight groups. The minority of groups with identical RCCX structure occurred once in the network, implying monophyletic origin, but the majority of groups occurred several times and in different locations, indicating polyphyletic origin. The monophyletic groups were often created by single unequal crossover, whereas recurrent unequal crossover events generated some of the polyphyletic groups. As a result of recurrent NAHR events, more CYP21A2 haplotype variants with different allele patterns belonged to the same RCCX structure. The intraspecific evolution of RCCX CNV described here has provided a reasonable expectation for that of complex, multiallelic, tandem CNVs in humans.","publication":null,"publication_with_fallback":"Genome Biology and Evolution","downloadable_attachments":[{"id":44884827,"asset_id":24554752,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44884827/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44884827/RCCX_evolution_Banlaki__2013-libre.pdf?1461065434=\u0026response-content-disposition=attachment%3B+filename%3DIntraspecific_Evolution_of_Human_RCCX_Co.pdf\u0026Expires=1732766622\u0026Signature=SCf379pjt11RXsnnLxJoqTT72g320oB1Xs2iH-c9adYti54PQBQg2Fb8snNkVegu5vNOUm6ryjtdTQheeH9aq143fMgwzGJ-3~ENSwUEX4EtUtLFkUwFnDNtANKkcE2xsAvtow92KCaD4QP86srSlzIS4YtMokDwXDYyuS0aRzfkzkRSDjOQRl0HJST5bHtEnk~xXfxeo12a6AulkRBG3qS~4jhjFHxKJ7TZYG-xwenq2CcLeRyk1cXVe~D9g7PGG-O8fB3MC0r5T7fCg-5zSo69spiiraqd3EQuUrYxe2kHjLiHK3k-7HiYM7Jr4I11RXGHlK~D27wu7MboU5AweA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44884827/download_file?st=MTczMjc2NTc5OCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44884827/mini_magick20190213-14025-s9et7m.png?1550092135"}],"downloadable_attachments_with_full_thumbnails":[{"id":44884827,"asset_id":24554752,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44884827/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44884827/RCCX_evolution_Banlaki__2013-libre.pdf?1461065434=\u0026response-content-disposition=attachment%3B+filename%3DIntraspecific_Evolution_of_Human_RCCX_Co.pdf\u0026Expires=1732766623\u0026Signature=br1thErBcMnWGCm2~1qDBtFAKbqUuELQJSqCR4wQs-u5sd59A1kqgzRQBZPieJo65sqOd~6~01cKbQNNTPqUMpPRFIbr2KGBPuTjtQJ3GbaVVT7rOeTru1jlPkSSMxy3ZJ93-0Ss2dZyC0cfe1fXyvAhpUVwwsnaMo7Mj3Vm1yRAAsaDhXeXImhXXfPU-9SPefaRyLBK~x4zX7z4CTQMCAWwyXpPuYlRBmRpsfKLzh-y6HIungviUJQw1FLYdJF8tl4UkARk8zxP-k0pE~v2ZeNDoylc8e-Ib0RjtdpPAMvuyYyHz55X8E96a-Eyy6mRAnfvjcj~ML-dhdnT9NMxxQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44884827/download_file?st=MTczMjc2NTc5OCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44884827/mini_magick20190213-14025-s9et7m.png?1550092135"}],"has_pdf":true,"has_fulltext":true,"page_count":15,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology","nofollow":false},{"id":1135,"name":"Human Genetics","url":"https://www.academia.edu/Documents/in/Human_Genetics","nofollow":false},{"id":74235,"name":"Copy Number Variation of DNA","url":"https://www.academia.edu/Documents/in/Copy_Number_Variation_of_DNA","nofollow":false}],"publication_year":null,"publication_year_with_fallback":2012,"paper_rank":null,"all_time_views":32,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24564342" data-work_id="24564342" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24564342/ACTH_induced_cortisol_release_is_related_to_the_copy_number_of_the_C4B_gene_encoding_the_fourth_component_of_complement_in_patients_with_non_functional_adrenal_incidentaloma">ACTH-induced cortisol release is related to the copy number of the C4B gene encoding the fourth component of complement in patients with non-functional adrenal incidentaloma</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24564342" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7d5db12468ab0c9d54ed46a020e9eeb9" rel="nofollow" data-download="{"attachment_id":44894360,"asset_id":24564342,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44894360/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24564342 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24564342"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24564342, container: ".js-paper-rank-work_24564342", }); });</script></li><li class="js-percentile-work_24564342 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24564342; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24564342"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24564342 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24564342"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24564342; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24564342]").text(description); $(".js-view-count-work_24564342").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24564342").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24564342"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="89997" href="https://www.academia.edu/Documents/in/Aldosterone">Aldosterone</a>, <script data-card-contents-for-ri="89997" type="text/json">{"id":89997,"name":"Aldosterone","url":"https://www.academia.edu/Documents/in/Aldosterone","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="103297" href="https://www.academia.edu/Documents/in/Corticosterone">Corticosterone</a>, <script data-card-contents-for-ri="103297" type="text/json">{"id":103297,"name":"Corticosterone","url":"https://www.academia.edu/Documents/in/Corticosterone","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" href="https://www.academia.edu/Documents/in/Aged">Aged</a><script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24564342]'), work: {"id":24564342,"title":"ACTH-induced cortisol release is related to the copy number of the C4B gene encoding the fourth component of complement in patients with non-functional adrenal incidentaloma","created_at":"2016-04-19T12:41:06.671-07:00","owner_id":46696509,"url":"https://www.academia.edu/24564342/ACTH_induced_cortisol_release_is_related_to_the_copy_number_of_the_C4B_gene_encoding_the_fourth_component_of_complement_in_patients_with_non_functional_adrenal_incidentaloma","slug":"ACTH_induced_cortisol_release_is_related_to_the_copy_number_of_the_C4B_gene_encoding_the_fourth_component_of_complement_in_patients_with_non_functional_adrenal_incidentaloma","dom_id":"work_24564342","summary":null,"publication":"Clinical Endocrinology","publication_with_fallback":"Clinical Endocrinology","downloadable_attachments":[{"id":44894360,"asset_id":24564342,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894360/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894360/j.1365-2265.2011.04247.x-libre.pdf20160419-16342-1kwxdn7?1461095262=\u0026response-content-disposition=attachment%3B+filename%3DACTH_induced_cortisol_release_is_related.pdf\u0026Expires=1732766623\u0026Signature=Iv59luFqJ5Dc366Ey~Ne9bPYOrwqpPusQHLdVkVJEv7GXXGsR0CLOgv~V4m5I9lenz3p5KAGicw80lYr6oRGvOdMTNCXE4oIA2HTcOdn-4bkjaq13wFpwos9~NIiO1ilkxpyh9DVN45W6evIv1mrQbfAHpcfumXsvRT2awmxSzRPUNVPdRm8Scn8yoCCu2g7h7IUWPB2hP174uNOsuGNefOLLOWsawUruRcuc7xOqxtkM5tOi4tlMsIZf~nZ6jn2WaXRkYSvPyuXfFKSLY5US0wh4IW91xZFfASMSkzFqni7bVKm6xImJ~W8icODwvl~yNZnxT4JoM5NgF6bNo172A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894360/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894360/mini_magick20190213-27721-p1cqyu.png?1550090148"}],"downloadable_attachments_with_full_thumbnails":[{"id":44894360,"asset_id":24564342,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894360/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894360/j.1365-2265.2011.04247.x-libre.pdf20160419-16342-1kwxdn7?1461095262=\u0026response-content-disposition=attachment%3B+filename%3DACTH_induced_cortisol_release_is_related.pdf\u0026Expires=1732766623\u0026Signature=Iv59luFqJ5Dc366Ey~Ne9bPYOrwqpPusQHLdVkVJEv7GXXGsR0CLOgv~V4m5I9lenz3p5KAGicw80lYr6oRGvOdMTNCXE4oIA2HTcOdn-4bkjaq13wFpwos9~NIiO1ilkxpyh9DVN45W6evIv1mrQbfAHpcfumXsvRT2awmxSzRPUNVPdRm8Scn8yoCCu2g7h7IUWPB2hP174uNOsuGNefOLLOWsawUruRcuc7xOqxtkM5tOi4tlMsIZf~nZ6jn2WaXRkYSvPyuXfFKSLY5US0wh4IW91xZFfASMSkzFqni7bVKm6xImJ~W8icODwvl~yNZnxT4JoM5NgF6bNo172A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894360/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894360/mini_magick20190213-27721-p1cqyu.png?1550090148"}],"has_pdf":true,"has_fulltext":true,"page_count":7,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":89997,"name":"Aldosterone","url":"https://www.academia.edu/Documents/in/Aldosterone","nofollow":false},{"id":103297,"name":"Corticosterone","url":"https://www.academia.edu/Documents/in/Corticosterone","nofollow":false},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":false},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged","nofollow":false},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":564888,"name":"Adrenocorticotropic Hormone","url":"https://www.academia.edu/Documents/in/Adrenocorticotropic_Hormone"},{"id":923234,"name":"Clinical Endocrinology","url":"https://www.academia.edu/Documents/in/Clinical_Endocrinology"}],"publication_year":2012,"publication_year_with_fallback":2012,"paper_rank":null,"all_time_views":11,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24564344" data-work_id="24564344" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24564344/Characterization_of_the_Nuclear_Factor_%CE%BAB_Responsiveness_of_the_Human_dio_2_Gene">Characterization of the Nuclear Factor-κB Responsiveness of the Human dio 2 Gene</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24564344" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="216a9a59fb825fcc118939c128bb3f7b" rel="nofollow" data-download="{"attachment_id":44894364,"asset_id":24564344,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44894364/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24564344 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24564344"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24564344, container: ".js-paper-rank-work_24564344", }); });</script></li><li class="js-percentile-work_24564344 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24564344; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24564344"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24564344 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24564344"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24564344; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24564344]").text(description); $(".js-view-count-work_24564344").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24564344").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24564344"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="154" href="https://www.academia.edu/Documents/in/Endocrinology">Endocrinology</a>, <script data-card-contents-for-ri="154" type="text/json">{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a>, <script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="48057" href="https://www.academia.edu/Documents/in/DNA">DNA</a><script data-card-contents-for-ri="48057" type="text/json">{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24564344]'), work: {"id":24564344,"title":"Characterization of the Nuclear Factor-κB Responsiveness of the Human dio 2 Gene","created_at":"2016-04-19T12:41:07.044-07:00","owner_id":46696509,"url":"https://www.academia.edu/24564344/Characterization_of_the_Nuclear_Factor_%CE%BAB_Responsiveness_of_the_Human_dio_2_Gene","slug":"Characterization_of_the_Nuclear_Factor_κB_Responsiveness_of_the_Human_dio_2_Gene","dom_id":"work_24564344","summary":null,"publication":"Endocrinology","publication_with_fallback":"Endocrinology","downloadable_attachments":[{"id":44894364,"asset_id":24564344,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894364/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894364/Characterization_of_the_nuclear_factor-B20160419-14611-n30a7p-libre.pdf?1461095262=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_the_Nuclear_Factor.pdf\u0026Expires=1732766623\u0026Signature=azL4~E0AGlpCVLzrdiyqVMKvDebahq1Tbn5p4kdZsnHZc3sbkjM8zzQHCwqhJmu7t1pOdQ9C0J8rQ-N8ZiyvmI~zP909aeBaT8kjLsWQDmaiDQJU27eObWFWdGa8qz71mrSnMabEZkvuahosgCGQiy3t51xiIe5Q927HwddWOI6KULaakP-oWmcKO8cjNjOw5INMHo2uFsRHlHmMjUY9Z3ySt8K36AUU-EJr5v6ubGQG-yVXrNhAyoO8dZi~y1-JuIqWMqAcKGOXDXPmcW6wFEwATCIhkmESNTcysoV5CRpDBBNRItfuS9-yZbGIUUmI-AMe~eW9Tc6snXkGDESGrA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894364/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894364/mini_magick20190213-26473-2r63ur.png?1550090095"}],"downloadable_attachments_with_full_thumbnails":[{"id":44894364,"asset_id":24564344,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894364/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894364/Characterization_of_the_nuclear_factor-B20160419-14611-n30a7p-libre.pdf?1461095262=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_the_Nuclear_Factor.pdf\u0026Expires=1732766623\u0026Signature=azL4~E0AGlpCVLzrdiyqVMKvDebahq1Tbn5p4kdZsnHZc3sbkjM8zzQHCwqhJmu7t1pOdQ9C0J8rQ-N8ZiyvmI~zP909aeBaT8kjLsWQDmaiDQJU27eObWFWdGa8qz71mrSnMabEZkvuahosgCGQiy3t51xiIe5Q927HwddWOI6KULaakP-oWmcKO8cjNjOw5INMHo2uFsRHlHmMjUY9Z3ySt8K36AUU-EJr5v6ubGQG-yVXrNhAyoO8dZi~y1-JuIqWMqAcKGOXDXPmcW6wFEwATCIhkmESNTcysoV5CRpDBBNRItfuS9-yZbGIUUmI-AMe~eW9Tc6snXkGDESGrA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894364/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894364/mini_magick20190213-26473-2r63ur.png?1550090095"}],"has_pdf":true,"has_fulltext":true,"page_count":11,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology","nofollow":false},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false},{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA","nofollow":false},{"id":153734,"name":"Mesothelioma","url":"https://www.academia.edu/Documents/in/Mesothelioma"},{"id":181936,"name":"Gene","url":"https://www.academia.edu/Documents/in/Gene"},{"id":316015,"name":"Gen","url":"https://www.academia.edu/Documents/in/Gen"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":1217930,"name":"Site-directed Mutagenesis","url":"https://www.academia.edu/Documents/in/Site-directed_Mutagenesis"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"}],"publication_year":2006,"publication_year_with_fallback":2006,"paper_rank":null,"all_time_views":9,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24564346" data-work_id="24564346" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24564346/Lipopolysaccharide_Induces_Type_2_Iodothyronine_Deiodinase_in_the_Mediobasal_Hypothalamus_Implications_for_the_Nonthyroidal_Illness_Syndrome">Lipopolysaccharide Induces Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus: Implications for the Nonthyroidal Illness Syndrome</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24564346" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fe9ac6afcaae6901ebe2b873e66f73aa" rel="nofollow" data-download="{"attachment_id":44894361,"asset_id":24564346,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44894361/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24564346 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24564346"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24564346, container: ".js-paper-rank-work_24564346", }); });</script></li><li class="js-percentile-work_24564346 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24564346; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24564346"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24564346 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24564346"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24564346; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24564346]").text(description); $(".js-view-count-work_24564346").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24564346").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24564346"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="154" href="https://www.academia.edu/Documents/in/Endocrinology">Endocrinology</a>, <script data-card-contents-for-ri="154" type="text/json">{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="48183" href="https://www.academia.edu/Documents/in/Lipopolysaccharide">Lipopolysaccharide</a>, <script data-card-contents-for-ri="48183" type="text/json">{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="78467" href="https://www.academia.edu/Documents/in/Cerebral_Cortex">Cerebral Cortex</a><script data-card-contents-for-ri="78467" type="text/json">{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24564346]'), work: {"id":24564346,"title":"Lipopolysaccharide Induces Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus: Implications for the Nonthyroidal Illness Syndrome","created_at":"2016-04-19T12:41:07.259-07:00","owner_id":46696509,"url":"https://www.academia.edu/24564346/Lipopolysaccharide_Induces_Type_2_Iodothyronine_Deiodinase_in_the_Mediobasal_Hypothalamus_Implications_for_the_Nonthyroidal_Illness_Syndrome","slug":"Lipopolysaccharide_Induces_Type_2_Iodothyronine_Deiodinase_in_the_Mediobasal_Hypothalamus_Implications_for_the_Nonthyroidal_Illness_Syndrome","dom_id":"work_24564346","summary":null,"publication":"Endocrinology","publication_with_fallback":"Endocrinology","downloadable_attachments":[{"id":44894361,"asset_id":24564346,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894361/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894361/Lipopolysaccharide_induces_type_2_iodoth20160419-13963-vel2mc-libre.pdf?1461095262=\u0026response-content-disposition=attachment%3B+filename%3DLipopolysaccharide_Induces_Type_2_Iodoth.pdf\u0026Expires=1732766623\u0026Signature=YXPQ2gODTExdj~nckJK4TgMZZmMXv7sLbzhGDnzDly3K8Hmh5KxkOH4WCXoXnQQAHTbVEfkkJE7MH0-Nnt8NMcUyiE3VGhKi1BCp2rV2Vahk~zmbnQV5xbRcRZbp62ZB5Vm9NXSr0DbR53XGZz3lnWocuulSNppNsnQPFUfN5c0ukCyIVB6hh~7vMAxYuK6nPAiSn6UasGErTKfpHuXI-a8gppfbPRsOBmDJUFPQW8IAHBxUobvV9RNP5eivtdBDcSSH11980DC~qgQjTiE5wLTxpxdwYAwMUIQlEgOVvqvOO9C80cdE-XK0lFrG3WICVbLNc9GiAbGkSd7I0PFBHA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894361/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894361/mini_magick20190213-26473-1hot3p6.png?1550090095"}],"downloadable_attachments_with_full_thumbnails":[{"id":44894361,"asset_id":24564346,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894361/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894361/Lipopolysaccharide_induces_type_2_iodoth20160419-13963-vel2mc-libre.pdf?1461095262=\u0026response-content-disposition=attachment%3B+filename%3DLipopolysaccharide_Induces_Type_2_Iodoth.pdf\u0026Expires=1732766623\u0026Signature=YXPQ2gODTExdj~nckJK4TgMZZmMXv7sLbzhGDnzDly3K8Hmh5KxkOH4WCXoXnQQAHTbVEfkkJE7MH0-Nnt8NMcUyiE3VGhKi1BCp2rV2Vahk~zmbnQV5xbRcRZbp62ZB5Vm9NXSr0DbR53XGZz3lnWocuulSNppNsnQPFUfN5c0ukCyIVB6hh~7vMAxYuK6nPAiSn6UasGErTKfpHuXI-a8gppfbPRsOBmDJUFPQW8IAHBxUobvV9RNP5eivtdBDcSSH11980DC~qgQjTiE5wLTxpxdwYAwMUIQlEgOVvqvOO9C80cdE-XK0lFrG3WICVbLNc9GiAbGkSd7I0PFBHA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894361/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894361/mini_magick20190213-26473-1hot3p6.png?1550090095"}],"has_pdf":true,"has_fulltext":true,"page_count":7,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences","nofollow":false},{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide","nofollow":false},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex","nofollow":false},{"id":104853,"name":"Hormones","url":"https://www.academia.edu/Documents/in/Hormones"},{"id":123418,"name":"NF-kappa B","url":"https://www.academia.edu/Documents/in/NF-kappa_B"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme"},{"id":240716,"name":"Body Temperature","url":"https://www.academia.edu/Documents/in/Body_Temperature"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":1602990,"name":"Anterior Pituitary","url":"https://www.academia.edu/Documents/in/Anterior_Pituitary"},{"id":2153835,"name":"Enzyme Induction","url":"https://www.academia.edu/Documents/in/Enzyme_Induction"}],"publication_year":2004,"publication_year_with_fallback":2004,"paper_rank":null,"all_time_views":18,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24564347" data-work_id="24564347" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24564347/Fine_tuned_characterization_of_RCCX_copy_number_variants_and_their_relationship_with_extended_MHC_haplotypes">Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24564347" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="09b5ff0ead236895bc42e3c0bb9b4557" rel="nofollow" data-download="{"attachment_id":44894362,"asset_id":24564347,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44894362/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24564347 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24564347"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24564347, container: ".js-paper-rank-work_24564347", }); });</script></li><li class="js-percentile-work_24564347 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24564347; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24564347"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24564347 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24564347"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24564347; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24564347]").text(description); $(".js-view-count-work_24564347").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24564347").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24564347"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="86952" href="https://www.academia.edu/Documents/in/Haplotypes">Haplotypes</a>, <script data-card-contents-for-ri="86952" type="text/json">{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="129904" href="https://www.academia.edu/Documents/in/Linkage">Linkage</a><script data-card-contents-for-ri="129904" type="text/json">{"id":129904,"name":"Linkage","url":"https://www.academia.edu/Documents/in/Linkage","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24564347]'), work: {"id":24564347,"title":"Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes","created_at":"2016-04-19T12:41:07.485-07:00","owner_id":46696509,"url":"https://www.academia.edu/24564347/Fine_tuned_characterization_of_RCCX_copy_number_variants_and_their_relationship_with_extended_MHC_haplotypes","slug":"Fine_tuned_characterization_of_RCCX_copy_number_variants_and_their_relationship_with_extended_MHC_haplotypes","dom_id":"work_24564347","summary":null,"publication":"Genes and Immunity","publication_with_fallback":"Genes and Immunity","downloadable_attachments":[{"id":44894362,"asset_id":24564347,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894362/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894362/gene.2012.29-libre.pdf20160419-15902-vi0ar2?1461095262=\u0026response-content-disposition=attachment%3B+filename%3DFine_tuned_characterization_of_RCCX_copy.pdf\u0026Expires=1732766623\u0026Signature=Rndi~efZGUEoSUCfQP5DCFj9~kHShfD52jwK1rZzq0JBMJzmNPoXsM8ze02lX1nidTMLlVwIjNDkDoaP5UL6vepPfzPVOPwQ1UTSpgsJulCh5A9OosXM-E4EUpXtLcK5DVi7r6vAyAkf3MC1Oy5tOkeGaloYfdlncldQts2KYoZjT6Wo6ljeWyIoHer-iF78OU-TgmvzfaeJk-E14zAx-Knj3WWX~BYiVb~0ro8zlJ1ZEv1bcZIghTH26Satsl60kJR9MhHkzXdOyp8R12xJbVowzzA6U2SFYf7zK~e4VukMUv1JHhzG4Za2gSGG8IbUoCSUjNQqOpR3WT19JkfTsA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894362/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894362/mini_magick20190213-19643-1xnhdkb.png?1550090105"}],"downloadable_attachments_with_full_thumbnails":[{"id":44894362,"asset_id":24564347,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894362/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894362/gene.2012.29-libre.pdf20160419-15902-vi0ar2?1461095262=\u0026response-content-disposition=attachment%3B+filename%3DFine_tuned_characterization_of_RCCX_copy.pdf\u0026Expires=1732766623\u0026Signature=Rndi~efZGUEoSUCfQP5DCFj9~kHShfD52jwK1rZzq0JBMJzmNPoXsM8ze02lX1nidTMLlVwIjNDkDoaP5UL6vepPfzPVOPwQ1UTSpgsJulCh5A9OosXM-E4EUpXtLcK5DVi7r6vAyAkf3MC1Oy5tOkeGaloYfdlncldQts2KYoZjT6Wo6ljeWyIoHer-iF78OU-TgmvzfaeJk-E14zAx-Knj3WWX~BYiVb~0ro8zlJ1ZEv1bcZIghTH26Satsl60kJR9MhHkzXdOyp8R12xJbVowzzA6U2SFYf7zK~e4VukMUv1JHhzG4Za2gSGG8IbUoCSUjNQqOpR3WT19JkfTsA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894362/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894362/mini_magick20190213-19643-1xnhdkb.png?1550090105"}],"has_pdf":true,"has_fulltext":true,"page_count":6,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics","nofollow":false},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology","nofollow":false},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes","nofollow":false},{"id":129904,"name":"Linkage","url":"https://www.academia.edu/Documents/in/Linkage","nofollow":false},{"id":181936,"name":"Gene","url":"https://www.academia.edu/Documents/in/Gene"},{"id":435727,"name":"Major histocompatibility complex","url":"https://www.academia.edu/Documents/in/Major_histocompatibility_complex"},{"id":561981,"name":"European Continental Ancestry Group","url":"https://www.academia.edu/Documents/in/European_Continental_Ancestry_Group"}],"publication_year":2012,"publication_year_with_fallback":2012,"paper_rank":null,"all_time_views":12,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24564349" data-work_id="24564349" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24564349/Regulation_of_thyroid_hormone_activation_via_the_liver_X_receptor_retinoid_X_receptor_pathway">Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24564349" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="07fb4368ac5a149f6186891538079e22" rel="nofollow" data-download="{"attachment_id":44894363,"asset_id":24564349,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44894363/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24564349 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24564349"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24564349, container: ".js-paper-rank-work_24564349", }); });</script></li><li class="js-percentile-work_24564349 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24564349; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24564349"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24564349 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24564349"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24564349; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24564349]").text(description); $(".js-view-count-work_24564349").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24564349").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24564349"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="154" href="https://www.academia.edu/Documents/in/Endocrinology">Endocrinology</a>, <script data-card-contents-for-ri="154" type="text/json">{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="29980" href="https://www.academia.edu/Documents/in/Animal_Production">Animal Production</a>, <script data-card-contents-for-ri="29980" type="text/json">{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a>, <script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="67484" href="https://www.academia.edu/Documents/in/Sequence_alignment">Sequence alignment</a><script data-card-contents-for-ri="67484" type="text/json">{"id":67484,"name":"Sequence alignment","url":"https://www.academia.edu/Documents/in/Sequence_alignment","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24564349]'), work: {"id":24564349,"title":"Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway","created_at":"2016-04-19T12:41:07.829-07:00","owner_id":46696509,"url":"https://www.academia.edu/24564349/Regulation_of_thyroid_hormone_activation_via_the_liver_X_receptor_retinoid_X_receptor_pathway","slug":"Regulation_of_thyroid_hormone_activation_via_the_liver_X_receptor_retinoid_X_receptor_pathway","dom_id":"work_24564349","summary":null,"publication":"Journal of Endocrinology","publication_with_fallback":"Journal of Endocrinology","downloadable_attachments":[{"id":44894363,"asset_id":24564349,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894363/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894363/Regulation_of_thyroid_hormone_activation20160419-4981-sd08kn-libre.pdf?1461095263=\u0026response-content-disposition=attachment%3B+filename%3DRegulation_of_thyroid_hormone_activation.pdf\u0026Expires=1732766623\u0026Signature=P0VNWOxkQLsGoBZ3CRrg7gBH369Rtj7uujL7~rRn01ZTGUSBLuzPfF1UuHnZD7PJ1RjQBBXohwUFDDZ0mMNdAXtdFflmz2cac1td0uQgWffZHXnlUkQJ9kRYRrcQgZ6jI9AbLad28gtMrBRxtY7R4HKyo2kHGP-XfaKo8zJRKGo7KqsDCivtb-BcUwKQ4QJiFSdeP2hiPvmvN2IdrirsvD9PCWEg2lHtYF2vd5j5Q-mmOjB0l~Ziva6mPFL1moP9yG~UzcWLwdMre6pnfn-jtigfzv~AjW7~0QABCWPdbxvd8-U9j9NryLUvGd1sJRvfyE-x~Fo7Nt3HmdI2RPz6Sw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894363/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894363/mini_magick20190213-14112-1lp43da.png?1550090106"}],"downloadable_attachments_with_full_thumbnails":[{"id":44894363,"asset_id":24564349,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894363/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894363/Regulation_of_thyroid_hormone_activation20160419-4981-sd08kn-libre.pdf?1461095263=\u0026response-content-disposition=attachment%3B+filename%3DRegulation_of_thyroid_hormone_activation.pdf\u0026Expires=1732766623\u0026Signature=P0VNWOxkQLsGoBZ3CRrg7gBH369Rtj7uujL7~rRn01ZTGUSBLuzPfF1UuHnZD7PJ1RjQBBXohwUFDDZ0mMNdAXtdFflmz2cac1td0uQgWffZHXnlUkQJ9kRYRrcQgZ6jI9AbLad28gtMrBRxtY7R4HKyo2kHGP-XfaKo8zJRKGo7KqsDCivtb-BcUwKQ4QJiFSdeP2hiPvmvN2IdrirsvD9PCWEg2lHtYF2vd5j5Q-mmOjB0l~Ziva6mPFL1moP9yG~UzcWLwdMre6pnfn-jtigfzv~AjW7~0QABCWPdbxvd8-U9j9NryLUvGd1sJRvfyE-x~Fo7Nt3HmdI2RPz6Sw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894363/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894363/mini_magick20190213-14112-1lp43da.png?1550090106"}],"has_pdf":true,"has_fulltext":true,"page_count":14,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology","nofollow":false},{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production","nofollow":false},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction","nofollow":false},{"id":67484,"name":"Sequence alignment","url":"https://www.academia.edu/Documents/in/Sequence_alignment","nofollow":false},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":402759,"name":"Chickens","url":"https://www.academia.edu/Documents/in/Chickens"},{"id":591594,"name":"Tretinoin","url":"https://www.academia.edu/Documents/in/Tretinoin"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":791301,"name":"Orphan Nuclear Receptors","url":"https://www.academia.edu/Documents/in/Orphan_Nuclear_Receptors"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":1643369,"name":"retinoid X receptor","url":"https://www.academia.edu/Documents/in/retinoid_X_receptor"}],"publication_year":2010,"publication_year_with_fallback":2010,"paper_rank":null,"all_time_views":8,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24564350" data-work_id="24564350" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24564350/Both_Positive_and_Negative_Selection_Pressures_Contribute_to_the_Polymorphism_Pattern_of_the_Duplicated_Human_CYP21A2_Gene">Both Positive and Negative Selection Pressures Contribute to the Polymorphism Pattern of the Duplicated Human CYP21A2 Gene</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24564350" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="45f6e60afa59fd470f29fcb9211c781b" rel="nofollow" data-download="{"attachment_id":44894365,"asset_id":24564350,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44894365/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24564350 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24564350"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24564350, container: ".js-paper-rank-work_24564350", }); });</script></li><li class="js-percentile-work_24564350 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24564350; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24564350"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24564350 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24564350"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24564350; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24564350]").text(description); $(".js-view-count-work_24564350").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24564350").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24564350"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="48" href="https://www.academia.edu/Documents/in/Engineering">Engineering</a>, <script data-card-contents-for-ri="48" type="text/json">{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="498" href="https://www.academia.edu/Documents/in/Physics">Physics</a>, <script data-card-contents-for-ri="498" type="text/json">{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a><script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24564350]'), work: {"id":24564350,"title":"Both Positive and Negative Selection Pressures Contribute to the Polymorphism Pattern of the Duplicated Human CYP21A2 Gene","created_at":"2016-04-19T12:41:08.000-07:00","owner_id":46696509,"url":"https://www.academia.edu/24564350/Both_Positive_and_Negative_Selection_Pressures_Contribute_to_the_Polymorphism_Pattern_of_the_Duplicated_Human_CYP21A2_Gene","slug":"Both_Positive_and_Negative_Selection_Pressures_Contribute_to_the_Polymorphism_Pattern_of_the_Duplicated_Human_CYP21A2_Gene","dom_id":"work_24564350","summary":null,"publication":"PLoS ONE","publication_with_fallback":"PLoS ONE","downloadable_attachments":[{"id":44894365,"asset_id":24564350,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894365/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894365/Both_Positive_and_Negative_Selection_Pre20160419-13963-vz2xt6-libre.pdf?1461095267=\u0026response-content-disposition=attachment%3B+filename%3DBoth_Positive_and_Negative_Selection_Pre.pdf\u0026Expires=1732766624\u0026Signature=a5xry0V8NFEWP3BcWuHBRHBBIx1egRDLKKuW4Mmo0mpGU54~EZ1dYjfLvmRFT-QQ1HuLEO7ruEmJ7Qna6Pz7e8CsSYjpoHowFqsm-GND4ETTco~q~JCz5g-tY3oY2lNwIoVhQSyzfRAAlndVUUjhI-~EqHvpAwI1f6rhrTd5ALDVhWLRsPYsg6YDpLDxaOJAvc2wz25GVI4l3J6IOnZolv4swWmnWUDJPQg9xPMhV~vDOukCs6-EwYoZqEdgebWu7Y8PKVJfiao6ctQTz5Nq0rz08RIWA~wemMZq0kUuabUsvvFre6nAD4Tyo1s4Gf0dV2NksRlPKuq0yNzcRSCBEA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894365/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894365/mini_magick20190213-19645-17zcu2n.png?1550090111"}],"downloadable_attachments_with_full_thumbnails":[{"id":44894365,"asset_id":24564350,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/44894365/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/44894365/Both_Positive_and_Negative_Selection_Pre20160419-13963-vz2xt6-libre.pdf?1461095267=\u0026response-content-disposition=attachment%3B+filename%3DBoth_Positive_and_Negative_Selection_Pre.pdf\u0026Expires=1732766624\u0026Signature=a5xry0V8NFEWP3BcWuHBRHBBIx1egRDLKKuW4Mmo0mpGU54~EZ1dYjfLvmRFT-QQ1HuLEO7ruEmJ7Qna6Pz7e8CsSYjpoHowFqsm-GND4ETTco~q~JCz5g-tY3oY2lNwIoVhQSyzfRAAlndVUUjhI-~EqHvpAwI1f6rhrTd5ALDVhWLRsPYsg6YDpLDxaOJAvc2wz25GVI4l3J6IOnZolv4swWmnWUDJPQg9xPMhV~vDOukCs6-EwYoZqEdgebWu7Y8PKVJfiao6ctQTz5Nq0rz08RIWA~wemMZq0kUuabUsvvFre6nAD4Tyo1s4Gf0dV2NksRlPKuq0yNzcRSCBEA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/44894365/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/44894365/mini_magick20190213-19645-17zcu2n.png?1550090111"}],"has_pdf":true,"has_fulltext":true,"page_count":15,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering","nofollow":false},{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics","nofollow":false},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes"},{"id":186941,"name":"Gene Duplication","url":"https://www.academia.edu/Documents/in/Gene_Duplication"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":283547,"name":"Introns","url":"https://www.academia.edu/Documents/in/Introns"}],"publication_year":2013,"publication_year_with_fallback":2013,"paper_rank":null,"all_time_views":14,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_53252352" data-work_id="53252352" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/53252352/Chromogranina_A_i_jej_rola_w_patogenezie_cukrzycy">Chromogranina A i jej rola w patogenezie cukrzycy</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/53252352" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8502397dcfcfb56ceeedc8b34bf0b898" rel="nofollow" data-download="{"attachment_id":70133636,"asset_id":53252352,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70133636/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_53252352 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="53252352"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 53252352, container: ".js-paper-rank-work_53252352", }); });</script></li><li class="js-percentile-work_53252352 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53252352; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_53252352"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_53252352 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="53252352"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53252352; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53252352]").text(description); $(".js-view-count-work_53252352").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_53252352").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_53252353" data-work_id="53252353" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/53252353/Serum_chromogranin_A_level_continuously_rises_with_the_progression_of_type_1_diabetes_and_indicates_the_presence_of_both_enterochromaffin_like_cell_hyperplasia_and_autoimmune_gastritis">Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin‐like cell hyperplasia and autoimmune gastritis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/53252353" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3d5115d0650d241aaece00b655b26bdc" rel="nofollow" data-download="{"attachment_id":70133662,"asset_id":53252353,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70133662/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_53252353 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="53252353"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 53252353, container: ".js-paper-rank-work_53252353", }); });</script></li><li class="js-percentile-work_53252353 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53252353; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_53252353"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_53252353 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="53252353"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53252353; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53252353]").text(description); $(".js-view-count-work_53252353").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_53252353").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_53252354" data-work_id="53252354" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/53252354/Lower_serum_chromogranin_B_level_is_associated_with_type_1_diabetes_and_with_type_2_diabetes_patients_with_intensive_conservative_insulin_treatment">Lower serum chromogranin B level is associated with type 1 diabetes and with type 2 diabetes patients with intensive conservative insulin treatment</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background Chromogranin B (CgB) plays an important role in the physiological insulin secretion of pancreatic beta cells. Serum CgB levels were investigated in type 1 and type 2 diabetes patients in a cross-sectional study. Methods An... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_53252354" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background Chromogranin B (CgB) plays an important role in the physiological insulin secretion of pancreatic beta cells. Serum CgB levels were investigated in type 1 and type 2 diabetes patients in a cross-sectional study. Methods An observational cross-sectional study was performed with the inclusion of 94 control subjects, 100 type 1 and 100 type 2 diabetes patients, at the Metabolic Outpatient Clinic of the Department of Internal Medicine and Hematology, Semmelweis University. Serum CgB levels were measured with enzyme-linked immunosorbent assay. Results Serum CgB level was lower in type 1 diabetes patients than in matched control subjects (p = 0.0241), while they were equal in type 2 diabetes patients and controls (p = 0.1698). The subgroup of type 2 diabetes patients who received intensive conservative insulin treatment had significantly lower CgB levels compared to those with other regimens of antidiabetic therapies (p = 0.0283). Conclusion The lower serum CgB levels in the pa...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/53252354" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="21ed925752e18178a79c1635852fe49b" rel="nofollow" data-download="{"attachment_id":70133639,"asset_id":53252354,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70133639/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46696509" href="https://sote.academia.edu/MartonDoleschall">Marton Doleschall</a><script data-card-contents-for-user="46696509" type="text/json">{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_53252354 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="53252354"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 53252354, container: ".js-paper-rank-work_53252354", }); });</script></li><li class="js-percentile-work_53252354 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53252354; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_53252354"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_53252354 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="53252354"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53252354; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53252354]").text(description); $(".js-view-count-work_53252354").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_53252354").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="53252354"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="244814" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3789880" href="https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics">Medical biochemistry and metabolomics</a><script data-card-contents-for-ri="3789880" type="text/json">{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=53252354]'), work: {"id":53252354,"title":"Lower serum chromogranin B level is associated with type 1 diabetes and with type 2 diabetes patients with intensive conservative insulin treatment","created_at":"2021-09-23T01:04:20.743-07:00","owner_id":46696509,"url":"https://www.academia.edu/53252354/Lower_serum_chromogranin_B_level_is_associated_with_type_1_diabetes_and_with_type_2_diabetes_patients_with_intensive_conservative_insulin_treatment","slug":"Lower_serum_chromogranin_B_level_is_associated_with_type_1_diabetes_and_with_type_2_diabetes_patients_with_intensive_conservative_insulin_treatment","dom_id":"work_53252354","summary":"Background Chromogranin B (CgB) plays an important role in the physiological insulin secretion of pancreatic beta cells. Serum CgB levels were investigated in type 1 and type 2 diabetes patients in a cross-sectional study. Methods An observational cross-sectional study was performed with the inclusion of 94 control subjects, 100 type 1 and 100 type 2 diabetes patients, at the Metabolic Outpatient Clinic of the Department of Internal Medicine and Hematology, Semmelweis University. Serum CgB levels were measured with enzyme-linked immunosorbent assay. Results Serum CgB level was lower in type 1 diabetes patients than in matched control subjects (p = 0.0241), while they were equal in type 2 diabetes patients and controls (p = 0.1698). The subgroup of type 2 diabetes patients who received intensive conservative insulin treatment had significantly lower CgB levels compared to those with other regimens of antidiabetic therapies (p = 0.0283). Conclusion The lower serum CgB levels in the pa...","publication":"Diabetology \u0026 Metabolic Syndrome","publication_with_fallback":"Diabetology \u0026 Metabolic Syndrome","downloadable_attachments":[{"id":70133639,"asset_id":53252354,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/70133639/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/70133639/s13098-020-00569-5-libre.pdf?1632385070=\u0026response-content-disposition=attachment%3B+filename%3DLower_serum_chromogranin_B_level_is_asso.pdf\u0026Expires=1732766624\u0026Signature=H3ZH6O1KlYPj34hLyp1TFgBWowIo~Rvds8UMH-f5bmKaCpRx7~k8C3k9vboaaFmJWkzu6MaU~Hvmkb9nCtSZb3GvPJ3o-DBQPC95AArtsk7yW8C1UBEeKIjxRimmXTZG1dbtWQBlM4V5uX4a58jYajM6J~XX6zczZvvfyzJs-8YazjepD3JYqTJQEUVB8vyxMA4RcYfLnjR5W38CvUToBJ29fdpPRp6sFmGlq6KfLbq4ZjwrLOaBmdaWXJ0C0pTOsRTUK4ADr-NNZvgZiTIbEPqv6~p6b2DBVw7fwvZRXDF3OZ79Wwc271t9wIN52VmsQaCyD~3wE6KbZEvGHS2wsw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/70133639/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/70133639/mini_magick20210923-12982-1haz86l.png?1632384308"}],"downloadable_attachments_with_full_thumbnails":[{"id":70133639,"asset_id":53252354,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/70133639/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/70133639/s13098-020-00569-5-libre.pdf?1632385070=\u0026response-content-disposition=attachment%3B+filename%3DLower_serum_chromogranin_B_level_is_asso.pdf\u0026Expires=1732766624\u0026Signature=H3ZH6O1KlYPj34hLyp1TFgBWowIo~Rvds8UMH-f5bmKaCpRx7~k8C3k9vboaaFmJWkzu6MaU~Hvmkb9nCtSZb3GvPJ3o-DBQPC95AArtsk7yW8C1UBEeKIjxRimmXTZG1dbtWQBlM4V5uX4a58jYajM6J~XX6zczZvvfyzJs-8YazjepD3JYqTJQEUVB8vyxMA4RcYfLnjR5W38CvUToBJ29fdpPRp6sFmGlq6KfLbq4ZjwrLOaBmdaWXJ0C0pTOsRTUK4ADr-NNZvgZiTIbEPqv6~p6b2DBVw7fwvZRXDF3OZ79Wwc271t9wIN52VmsQaCyD~3wE6KbZEvGHS2wsw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/70133639/download_file?st=MTczMjc2NTc5OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/70133639/mini_magick20210923-12982-1haz86l.png?1632384308"}],"has_pdf":true,"has_fulltext":true,"page_count":5,"ordered_authors":[{"id":46696509,"first_name":"Marton","last_name":"Doleschall","domain_name":"sote","page_name":"MartonDoleschall","display_name":"Marton Doleschall","profile_url":"https://sote.academia.edu/MartonDoleschall","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences","nofollow":false},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics","nofollow":false}],"publication_year":null,"publication_year_with_fallback":2020,"paper_rank":null,"all_time_views":14,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div></div></div><div class="u-taCenter Pagination"></div></div></div></div></div></div></div> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "8cd842e8cb5396e9b347198934d5df7294222855e498e96bf1fbd58f3f5a166a", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="TbI+/U+P5I8iiuqZC9Ttfew17rmfI6oRRHWL47x37nBg3sa3+hZ6Atz7X0HvK7V9msshA/iYv/O1dMTi7ICTYg==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://sote.academia.edu/Departments/Molecular_Medicine_Research_Group/Documents" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="/JeZDN3ji5PXdEXqRcXFF/bECqweDOr8zndDi828hzjR+2FGaHoVHikF8DKhOp0XgDrFFnm3/x4/dgyKnUv6Kg==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style=""><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style=""><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>