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Barends</h3></div><div class="js-work-strip profile--work_container" data-work-id="124445142"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124445142/Early_detection_of_myocardial_dysfunction_in_children_with_beta_thalassaemia_major"><img alt="Research paper thumbnail of Early detection of myocardial dysfunction in children with beta-thalassaemia major" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124445142/Early_detection_of_myocardial_dysfunction_in_children_with_beta_thalassaemia_major">Early detection of myocardial dysfunction in children with beta-thalassaemia major</a></div><div class="wp-workCard_item"><span>The International Journal of Cardiovascular Imaging</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate left and right ventricular myocardial performance using pulsed-tissue Doppler imaging...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate left and right ventricular myocardial performance using pulsed-tissue Doppler imaging (TDI) and its relation to BNP levels in patients with beta-thalassaemia major (beta-TM). We enrolled 36 thalassaemic patients (21 male, 15 female; mean age: 14.2 +/- 4.1 years) with normal left ventricular systolic and diastolic functions with conventional echocardiography and 30 healthy control subjects (18 male, 12 female, and 12.5 +/- 4.2 years). Myocardial performance indexes (MPI) of left ventricular (LV) lateral wall, interventricular septum (IVS) and right ventricular (RV) lateral wall were calculated with TDI. Plasma BNP levels were measured in all patients. MPIs and other echocardiographic parameters of patients with beta-TM were compared with control group. All the patients&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; plasma BNP levels were within normal limits. There were no differences between conventional echocardiographic parameters of patients and control group. MPI of LV, IVS, and RV of patients were significantly higher than control group (P = 0.01, and P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01, and P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, respectively). Our study confirms that MPI obtained by TDI seems to be an early sensitive parameter of cardiac dysfunction in beta-TM. We concluded that MPI obtained by TDI may be an adjunctive parameter to conventional echocardiography for detecting early myocardial damage.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124445142"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124445142"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124445142; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124445142]").text(description); $(".js-view-count[data-work-id=124445142]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124445142; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124445142']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124445142]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124445142,"title":"Early detection of myocardial dysfunction in children with beta-thalassaemia major","internal_url":"https://www.academia.edu/124445142/Early_detection_of_myocardial_dysfunction_in_children_with_beta_thalassaemia_major","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827621"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827621/Considerations_on_the_use_of_nucleic_acid_based_amplification_for_malaria_parasite_detection"><img alt="Research paper thumbnail of Considerations on the use of nucleic acid-based amplification for malaria parasite detection" class="work-thumbnail" src="https://attachments.academia-assets.com/104452504/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827621/Considerations_on_the_use_of_nucleic_acid_based_amplification_for_malaria_parasite_detection">Considerations on the use of nucleic acid-based amplification for malaria parasite detection</a></div><div class="wp-workCard_item"><span>Malaria Journal</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Nucleic acid amplification provides the most sensitive and accurate method to detect a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Nucleic acid amplification provides the most sensitive and accurate method to detect and identify pathogens. This is primarily useful for epidemiological investigations of malaria because the infections, often with two or more Plasmodium species present simultaneously, are frequently associated with microscopically sub-patent parasite levels and cryptic mixed infections. Numerous distinct equally adequate amplification-based protocols have been described, but it is unclear which to select for epidemiological surveys. Few comparative studies are available, and none that addresses the issue of inter-laboratory variability. Methods Blood samples were collected from patients attending malaria clinics on the Thai-Myanmar border. Frozen aliquots from 413 samples were tested independently in two laboratories by nested PCR assay. Dried blood spots on filter papers from the same patients were also tested by the nested PCR assay in one laboratory and by a multiplex PCR assay in ano...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="99c9e7a0e4dce77b516fa97e03b493ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452504,"asset_id":104827621,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452504/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827621"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827621"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827621; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827621]").text(description); $(".js-view-count[data-work-id=104827621]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827621; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827621']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "99c9e7a0e4dce77b516fa97e03b493ee" } } $('.js-work-strip[data-work-id=104827621]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827621,"title":"Considerations on the use of nucleic acid-based amplification for malaria parasite detection","internal_url":"https://www.academia.edu/104827621/Considerations_on_the_use_of_nucleic_acid_based_amplification_for_malaria_parasite_detection","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827620"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827620/Timing_of_Infection_and_Prior_Immunization_with_Respiratory_Syncytial_Virus_RSV_in_RSV_Enhanced_Allergic_Inflammation"><img alt="Research paper thumbnail of Timing of Infection and Prior Immunization with Respiratory Syncytial Virus (RSV) in RSV‐Enhanced Allergic Inflammation" class="work-thumbnail" src="https://attachments.academia-assets.com/104452506/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827620/Timing_of_Infection_and_Prior_Immunization_with_Respiratory_Syncytial_Virus_RSV_in_RSV_Enhanced_Allergic_Inflammation">Timing of Infection and Prior Immunization with Respiratory Syncytial Virus (RSV) in RSV‐Enhanced Allergic Inflammation</a></div><div class="wp-workCard_item"><span>The Journal of Infectious Diseases</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e157259185f1a6bac2c1300dd817901c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452506,"asset_id":104827620,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452506/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827620"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827620"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827620; 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Dihydroartemisinin-piperaquine (DP) is a fixed-combination antimalarial drug increasi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Dihydroartemisinin-piperaquine (DP) is a fixed-combination antimalarial drug increasingly deployed in Southeast Asia. The current regimen involves 4 doses given over 3 days. Simplification of the dose regimen should facilitate treatment adherence and thereby increase effectiveness. Methods. In a randomized, controlled, 3-arm trial conducted along the northwestern border of Thailand, the standard 4-dose course of DP (DP4) was compared to an equivalent dose given as a once-daily regimen (DP3) and to the standard treatment of mefloquine-artesunate (MAS3). Results. A total of 499 patients were included in the study. Times to fever and parasite clearance were similar in all groups. The PCR genotyping-adjusted cure rates at day 63 after treatment initiation were 95.7% (95% confidence interval [95% CI], 92.2%-98.9%) for MAS3, 100% for DP4, and 99.4% (95% CI, 98.1%-100%) for DP3. The DP4 and DP3 cure rates were significantly higher than that for MAS3 (and , respectively). P p .008 P p .03 All regimens were well tolerated. There were 3 deaths (1 in the MAS3 group and 2 in the DP3 group), all of which were considered to be unrelated to treatment. Rates of other adverse events were comparable between the groups, except for diarrhea, which was more common in the DP4 group (vs. the MAS3 group). P p .05 Conclusions. A once-daily, 3-dose regimen of DP is a highly efficacious treatment for multidrug-resistant falciparum malaria. This simple, safe, and relatively inexpensive fixed combination could become the treatment of choice for falciparum malaria. Dihydroartemisinin-piperaquine (DP) is an artemisinin-containing, fixed-combination antimalarial drug developed in China. Recent randomized clinical trials in Cambodia, Vietnam, and Thailand indicate excellent tolerability and high cure rates against multidrugresistant falciparum malaria [1-3]. DP is being used increasingly in Southeast Asia and is already part of national treatment recommendations in Cambodia and Vietnam. Dihydroartemisinin is a highly active artemisinin de</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1352227db568e28028e6792770040fee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452505,"asset_id":104827619,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452505/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827619"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827619"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827619; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827619]").text(description); $(".js-view-count[data-work-id=104827619]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827619; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827619']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1352227db568e28028e6792770040fee" } } $('.js-work-strip[data-work-id=104827619]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827619,"title":"A Randomized, Controlled Study of a Simple, Once-Daily Regimen of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated, Multidrug-Resistant Falciparum Malaria","internal_url":"https://www.academia.edu/104827619/A_Randomized_Controlled_Study_of_a_Simple_Once_Daily_Regimen_of_Dihydroartemisinin_Piperaquine_for_the_Treatment_of_Uncomplicated_Multidrug_Resistant_Falciparum_Malaria","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[{"id":104452505,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104452505/thumbnails/1.jpg","file_name":"41-4-425.pdf","download_url":"https://www.academia.edu/attachments/104452505/download_file","bulk_download_file_name":"A_Randomized_Controlled_Study_of_a_Simpl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104452505/41-4-425-libre.pdf?1690062836=\u0026response-content-disposition=attachment%3B+filename%3DA_Randomized_Controlled_Study_of_a_Simpl.pdf\u0026Expires=1740544799\u0026Signature=alcC0cVrlABKAuXmmFYrSUKt~FAGJEDefDeWd-YetRDls56XcYMUh3SwSXKaJyr84uSRuegeR7UWuTf0ODeQuAVa67HzHf3u0DnKK0T0fF1cm5-kOKK-Rt2mftcPHnL-3TGOFJiRAitGUdbaQNUgf7sxC0Re8CvrijcL3tr5oOcAw02a0uedDZzzY09cKlmIjy6pIgYroEmyiqNS6Qv3P7hDuM4FWJpfq7W4UIoKx5F1HsR6OhNobAeuUhqBXcp5kCFuy0DHUXFbwUll6uod3yK~M2VAJCGm-uFeEVM3D2YdTsYj6mz7P-DAfoIxHGwKbyuzUsrNVMP~pMVcD4XIfQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827618"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104827618/Influence_of_respiratory_syncytial_virus_infection_on_cytokine_and_inflammatory_responses_in_allergic_mice"><img alt="Research paper thumbnail of Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104827618/Influence_of_respiratory_syncytial_virus_infection_on_cytokine_and_inflammatory_responses_in_allergic_mice">Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice</a></div><div class="wp-workCard_item"><span>Clinical &amp; Experimental Allergy</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Th2 lymphocyte responses are associated with inflammation and disease during allergic responses. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Th2 lymphocyte responses are associated with inflammation and disease during allergic responses. Exposure to particular environmental factors during the expression of allergy could result in more pronounced Th2-like immune responses and more severe disease. One factor might be a respiratory virus infection. The aim of our study was to investigate the influence of respiratory syncytial virus (RSV) infection on the expression of ovalbumin (OVA)-induced allergy in BALB/c mice. We determined OVA-specific IgE in serum, cytokine profiles and histopathological lesions in lungs of OVA-allergic mice after RSV infection. OVA sensitization and challenge induced OVA-specific IgE in serum, Th2 cytokine mRNA expression, and mononuclear and eosinophilic inflammation in the lungs. RSV inoculation during the challenge period enhanced OVA-induced IL-4 and IL-5 mRNA expression in lung tissue. RSV further enhanced the OVA-induced hypertrophy of mucous cells and eosinophilic infiltration in lung tissue. Surprisingly, RSV infection decreased Th2 cytokine secretion and eosinophilic influx in bronchoalveolar lavage of OVA-allergic mice. Because inactivated RSV did not influence these responses, replication of RSV appeared essential for the modification of OVA-induced Th2 cytokine expression. RSV did not change OVA-specific IgE levels in serum. Furthermore, the RSV-induced IL-12 mRNA expression in lung tissue of OVA-allergic mice was diminished, but IFN-gamma mRNA expression was not affected. RSV infection enhanced particular OVA-induced Th2 cytokine mRNA responses and pulmonary lesions in allergic mice and thus aggravated allergic respiratory disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827618"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827618"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827618; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827618]").text(description); $(".js-view-count[data-work-id=104827618]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827618; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827618']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104827618]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827618,"title":"Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice","internal_url":"https://www.academia.edu/104827618/Influence_of_respiratory_syncytial_virus_infection_on_cytokine_and_inflammatory_responses_in_allergic_mice","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827614"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827614/In_vitro_activity_of_ferroquine_SSR_97193_against_Plasmodium_falciparum_isolates_from_the_Thai_Burmese_border"><img alt="Research paper thumbnail of In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border" class="work-thumbnail" src="https://attachments.academia-assets.com/104452499/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827614/In_vitro_activity_of_ferroquine_SSR_97193_against_Plasmodium_falciparum_isolates_from_the_Thai_Burmese_border">In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border</a></div><div class="wp-workCard_item"><span>Malaria Journal</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background On the borders of Thailand, Plasmodium falciparum has become resistant to nearly all a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background On the borders of Thailand, Plasmodium falciparum has become resistant to nearly all available drugs, and there is an urgent need to find new antimalarial drugs or drug combinations. Ferroquine (SSR97193) is a new 4-aminoquinoline antimalarial active against chloroquine resistant and sensitive P. falciparum strains in vivo and in vitro. This antimalarial organic iron complex (a ferrocenyl group has been associated with chloroquine) is meant to use the affinity of Plasmodium for iron to increase the probability for encountering the anti-malarial molecule. The aim of the present study was to investigate the activity of ferroquine against P. falciparum isolates from an area with a known high multi-drug resistance rate. Methods Parasite isolates were obtained from patients with acute falciparum malaria attending the clinics of SMRU. In vitro cultures of these isolates were set-up in the SMRU-laboratory on pre-dosed drug plates, and grown in culture for 42 hours. Parasite grow...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d3b2ea9b2ed8df25f5fe16064c96cb3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452499,"asset_id":104827614,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452499/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827614"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827614"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827614; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827614]").text(description); $(".js-view-count[data-work-id=104827614]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827614; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827614']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1d3b2ea9b2ed8df25f5fe16064c96cb3" } } $('.js-work-strip[data-work-id=104827614]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827614,"title":"In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border","internal_url":"https://www.academia.edu/104827614/In_vitro_activity_of_ferroquine_SSR_97193_against_Plasmodium_falciparum_isolates_from_the_Thai_Burmese_border","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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An important first step is to determine trait heritability ( H 2 ). We evaluate two approaches to measuring H 2 in natural parasite populations using relatedness inferred from genetic marker data. We collected single-clone Plasmodium falciparum infections from 185 patients from the Thailand–Burma border, monitored parasite clearance following treatment with artemisinin combination therapy (ACT), measured resistance to six antimalarial drugs and genotyped parasites using 335 microsatellites. We found strong relatedness structure. There were 27 groups of two to eight clonally identical (CI) parasites, and 74 per cent of parasites showed significant relatedness to one or more other parasites. Initially, we used matrices of allele sharing and variance compo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="760e0de9b11cdfbda5ca649fc88b3507" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452498,"asset_id":104827613,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452498/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827613"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827613"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827613; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827613]").text(description); $(".js-view-count[data-work-id=104827613]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827613; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827613']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "760e0de9b11cdfbda5ca649fc88b3507" } } $('.js-work-strip[data-work-id=104827613]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827613,"title":"Inferred relatedness and heritability in malaria parasites","internal_url":"https://www.academia.edu/104827613/Inferred_relatedness_and_heritability_in_malaria_parasites","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[{"id":104452498,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104452498/thumbnails/1.jpg","file_name":"rspb.2010.pdf","download_url":"https://www.academia.edu/attachments/104452498/download_file","bulk_download_file_name":"Inferred_relatedness_and_heritability_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104452498/rspb.2010-libre.pdf?1690062845=\u0026response-content-disposition=attachment%3B+filename%3DInferred_relatedness_and_heritability_in.pdf\u0026Expires=1740544799\u0026Signature=Nnu~dDTD~xbyeAZ5YQuUXwkXb26tp35oUWho0qGu6mRYZiuLUyvKSTNMu7cM~OOC~oPYpyIzCjDZUVIfAoUWC8D-SN-5KvEQGRDEvUAwRCMBe0Gh40EeL0D0dG3eupQFI4~2MfGSXV~nPUlwJHu0dxnuRpiQqXnFQlOtJN89STWb7CCwBitpdHAAKKhGXx-3JwyVsDJFNdMNmeikP8dZSXk9QtgSdPMRVKFEyHJ9GVrcv009QOz8srlYREGFPWmylqgaBBOYMTOa5JlSkPg2bRDjQdQDe-l~Q1dAxTGian6xD~DYSL66Nve8ezFhSsAYE8pCaVM~AD0omPWt3QkYaQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827612"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104827612/Chloroquine_Resistant_Plasmodium_vivax_In_Vitro_Characterisation_and_Association_with_Molecular_Polymorphisms"><img alt="Research paper thumbnail of Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104827612/Chloroquine_Resistant_Plasmodium_vivax_In_Vitro_Characterisation_and_Association_with_Molecular_Polymorphisms">Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms</a></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827612"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827612"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827612; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827612]").text(description); $(".js-view-count[data-work-id=104827612]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827612; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827612']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104827612]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827612,"title":"Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms","internal_url":"https://www.academia.edu/104827612/Chloroquine_Resistant_Plasmodium_vivax_In_Vitro_Characterisation_and_Association_with_Molecular_Polymorphisms","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827611"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827611/Amplification_ofpvmdr1Associated_with_Multidrug_ResistantPlasmodium_vivax"><img alt="Research paper thumbnail of Amplification ofpvmdr1Associated with Multidrug‐ResistantPlasmodium vivax" class="work-thumbnail" src="https://attachments.academia-assets.com/104452497/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827611/Amplification_ofpvmdr1Associated_with_Multidrug_ResistantPlasmodium_vivax">Amplification ofpvmdr1Associated with Multidrug‐ResistantPlasmodium vivax</a></div><div class="wp-workCard_item"><span>The Journal of Infectious Diseases</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia. Metho...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia. Methods. In vitro drug susceptibility and pvmdr1 genotype were determined in P. vivax field isolates from Indonesia and Thailand. Results. Increased pvmdr1 copy number was present in 21% of isolates from Thailand (15/71) and none from Indonesia (0/114; P Ͻ .001). Compared with Indonesian isolates, the median IC 50 of Thai isolates was lower for chloroquine (36 vs. 114 nmol/L; P Ͻ .001) but higher for amodiaquine (34 vs. 13.7 nmol/L; P ϭ .032), artesunate (8.33 vs. 1.58 nmol/L; P Ͻ .001), and mefloquine (111 vs. 9.87 nmol/L; P Ͻ .001). In 11 cryopreserved Thai isolates, those with increased pvmdr1 copy number had a higher IC 50 for mefloquine (78.6 vs. 38 nmol/L for single-copy isolates; P ϭ .006). Compared with isolates with the wild-type allele, the Y976F mutation of pvmdr1 was associated with reduced susceptibility to chloroquine (154 nmol/L [range, 4.6-3505] vs. 34 nmol/L [range, 6.7-149]; P Ͻ .001) but greater susceptibility to artesunate (1.8 vs. 9.5 nmol/L; P ϭ .009) and mefloquine (14 vs. 121 nmol/L; P Ͻ .001). Conclusions. Amplification of pvmdr1 and single-nucleotide polymorphisms are correlated with susceptibility of P. vivax to multiple antimalarial drugs. Chloroquine and mefloquine appear to exert competitive evolutionary pressure on pvmdr1, similar to that observed with pfmdr1 in Plasmodium falciparum.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e1b061de0502908a03e55bd757fe70f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452497,"asset_id":104827611,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452497/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827611"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827611"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827611; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827611]").text(description); $(".js-view-count[data-work-id=104827611]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827611; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827611']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e1b061de0502908a03e55bd757fe70f3" } } $('.js-work-strip[data-work-id=104827611]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827611,"title":"Amplification ofpvmdr1Associated with Multidrug‐ResistantPlasmodium vivax","internal_url":"https://www.academia.edu/104827611/Amplification_ofpvmdr1Associated_with_Multidrug_ResistantPlasmodium_vivax","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[{"id":104452497,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104452497/thumbnails/1.jpg","file_name":"198-10-1558.pdf","download_url":"https://www.academia.edu/attachments/104452497/download_file","bulk_download_file_name":"Amplification_ofpvmdr1Associated_with_Mu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104452497/198-10-1558-libre.pdf?1690062845=\u0026response-content-disposition=attachment%3B+filename%3DAmplification_ofpvmdr1Associated_with_Mu.pdf\u0026Expires=1740544799\u0026Signature=gWqgR66of58AIBO1RaDUztHsqwWX3ARh~P6Au2eK~6z29eUphWq7Y~PoadDNj9zYwWwQf9drxyZc326iUnL1wq7aRSKsmvsA-2A0JxWnfz4VPJzkhMUZikDbA4ThJb35-xFCJjRzjPf~3j0QSk3ltEHFCKkCONON5D4m5RdzSX8WobrBfs-GnwKzszxabFf1I-O~z7~gaL9oaYP1Zz9rB1mBGvvohPB1nZHrYc3Mk~SZ4AewXUhYJx3vrEc4sI9A7yBnvcWl5QhXO6xiWKTopRFw993gFzp9E7HcohEegcfshhaVlm8auAO4oEN0cCIIIND6tllIfipu99JV912GgA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827610"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827610/A_Randomized_Comparison_of_Artesunate_Atovaquone_Proguanil_versus_Quinine_in_Treatment_for_Uncomplicated_Falciparum_Malaria_during_Pregnancy"><img alt="Research paper thumbnail of A Randomized Comparison of Artesunate‐Atovaquone‐Proguanil versus Quinine in Treatment for Uncomplicated Falciparum Malaria during Pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/104452495/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827610/A_Randomized_Comparison_of_Artesunate_Atovaquone_Proguanil_versus_Quinine_in_Treatment_for_Uncomplicated_Falciparum_Malaria_during_Pregnancy">A Randomized Comparison of Artesunate‐Atovaquone‐Proguanil versus Quinine in Treatment for Uncomplicated Falciparum Malaria during Pregnancy</a></div><div class="wp-workCard_item"><span>The Journal of Infectious Diseases</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. There is no safe, practical, and effective treatment for pregnant women infected with...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. There is no safe, practical, and effective treatment for pregnant women infected with multidrugresistant Plasmodium falciparum. Methods. We recruited pregnant Karen women in the second or third trimesters of pregnancy who had uncomplicated falciparum malaria for a randomized, open-label trial with a restricted sequential trial design of 7 days of supervised quinine (SQ7) versus 3 days of artesunate-atovaquone-proguanil (AAP). Results. Eight-one pregnant women entered the study between December 2001 and July 2003; 42 were treated with SQ7 and 39 were treated with AAP. Fever, parasite clearance, and duration of anemia were significantly better with AAP; the treatment failure rate was 7 times lower (5% [2/39] vs. 37% [15/41]; relative risk, 7.1 [95% confidence interval, 1.7-29.2];). There were no significant differences in birth weight, duration of gestation, or P p .001 congenital abnormality rates in newborns or in growth and developmental parameters of infants monitored for 1 year. Conclusion. AAP is a well-tolerated, effective, practical, but expensive treatment for multidrug-resistant falciparum malaria during the second or third trimesters of pregnancy. Despite the small number of subjects, our results add to the growing body of evidence that AAP is safe for the mother and the fetus. Plasmodium falciparum infection during pregnancy has deleterious consequences for both mother and fetus; in low-transmission settings, it is potentially lethal [1]. There are few safe and effective therapeutic options during pregnancy. Concerns about fetal toxicity have caused researchers to exclude pregnant and lactating women from antimalarial drug trials. Quinine is considered to be safe during all trimesters of pregnancy, and it is widely recommended as a treatment, although adverse effects are common and adherence is poor. New drugs are needed, but the pharmaceutical industry is</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b4cc942bf6029e6e462df5dd132227c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452495,"asset_id":104827610,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452495/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827610"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827610"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827610; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827610]").text(description); $(".js-view-count[data-work-id=104827610]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827610; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827610']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b4cc942bf6029e6e462df5dd132227c5" } } $('.js-work-strip[data-work-id=104827610]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827610,"title":"A Randomized Comparison of Artesunate‐Atovaquone‐Proguanil versus Quinine in Treatment for Uncomplicated Falciparum Malaria during Pregnancy","internal_url":"https://www.academia.edu/104827610/A_Randomized_Comparison_of_Artesunate_Atovaquone_Proguanil_versus_Quinine_in_Treatment_for_Uncomplicated_Falciparum_Malaria_during_Pregnancy","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P . vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P . vivax malaria.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827609"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827609"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827609; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827609]").text(description); $(".js-view-count[data-work-id=104827609]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827609; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827609']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104827609]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827609,"title":"Plasmodium vivax Susceptibility to Ferroquine","internal_url":"https://www.academia.edu/104827609/Plasmodium_vivax_Susceptibility_to_Ferroquine","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827602"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827602/Efficacy_and_effectiveness_of_dihydroartemisinin_piperaquine_versus_artesunate_mefloquine_in_falciparum_malaria_an_open_label_randomised_comparison"><img alt="Research paper thumbnail of Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison" class="work-thumbnail" src="https://attachments.academia-assets.com/104452508/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827602/Efficacy_and_effectiveness_of_dihydroartemisinin_piperaquine_versus_artesunate_mefloquine_in_falciparum_malaria_an_open_label_randomised_comparison">Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison</a></div><div class="wp-workCard_item"><span>The Lancet</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Artemisinin-based combinations are judged the best treatments for multidrug-resistant ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Artemisinin-based combinations are judged the best treatments for multidrug-resistant Plasmodium falciparum malaria. Artesunate-mefl oquine is widely recommended in southeast Asia, but its high cost and tolerability profi le remain obstacles to widespread deployment. To assess whether dihydroartemisinin-piperaquine is a suitable alternative to artesunate-mefl oquine, we compared the safety, tolerability, effi cacy, and eff ectiveness of the two regimens for the treatment of uncomplicated falciparum in western Myanmar (Burma). Methods We did an open randomised comparison of 3-day regimens of artesunate-mefl oquine (12/25 mg/kg) versus dihydroartemisinin-piperaquine (6•3/50 mg/kg) for the treatment of children aged 1 year or older and in adults with uncomplicated falciparum malaria in Rakhine State, western Myanmar. Within each group, patients were randomly assigned supervised or non-supervised treatment. The primary endpoint was the PCR-confi rmed parasitological failure rate by day 42. Failure rates at day 42 were estimated by Kaplan-Meier survival analysis. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN27914471. Findings Of 652 patients enrolled, 327 were assigned dihydroartemisinin-piperaquine (156 supervised and 171 not supervised), and 325 artesunate-mefl oquine (162 and 163, respectively). 16 patients were lost to follow-up, and one patient died 22 days after receiving dihydroartemisinin-piperaquine. Recrudescent parasitaemias were confi rmed in only two patients; the day 42 failure rate was 0•6% (95% CI 0•2-2•5) for dihydroartemisinin-piperaquine and 0 (0-1•2) for artesunate-mefl oquine. Whole-blood piperaquine concentrations at day 7 were similar for patients with observed and non-observed dihydroartemisinin-piperaquine treatment. Gametocytaemia developed more frequently in patients who had received dihydroartemisinin-piperaquine than in those on artesunate-mefl oquine: day 7, 18 (10%) of 188 versus fi ve (2%) of 218; relative risk 4•2 (1•6-11•0) p=0•011. Interpretation Dihydroartemisinin-piperaquine is a highly effi cacious and inexpensive treatment of multidrugresistant falciparum malaria and is well tolerated by all age groups. The eff ectiveness of the unsupervised treatment, as in the usual context of use, equalled its supervised effi cacy, indicating good adherence without supervision. 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We used the double-site enzyme-linked pLDH immunodetection (DELI) assay to estimate the in vitro antimalarial drug susceptibility of 108 fresh P. falciparum isolates from southern Laos. The geometric mean (95% confidence interval) 50% inhibitory concentration values (nmol/L) were 152.4 (123.8-187.6) for chloroquine, 679.8 (533.8-863.0) for quinine, 45.9 (37.9-55.7) for mefloquine, 5.0 (4.4-6.4) for artesunate, 6.3 (4.5-8.9) for dihydroartemisinin, and 59.1 (46.4-75.3) for lumefantrine. The proportion of isolates defined as resistant were 65%, 40%, and 8% for chloroquine, quinine, and mefloquine, respectively. Of 53 isolates genotyped for the pfcrt T76K chloroquine-resistance mutation, 48 (91%) were mutants. P. falciparum in Laos is multi-drug resistant; antimalarial immunity resulting from the use of ineffective chloroquine before 2005 probably contributes significantly to the therapeutic responses in clinical trials.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c9ec39925806232438442bdf7d9270dd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95324160,"asset_id":92271584,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95324160/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92271584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92271584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92271584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92271584]").text(description); $(".js-view-count[data-work-id=92271584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92271584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92271584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c9ec39925806232438442bdf7d9270dd" } } $('.js-work-strip[data-work-id=92271584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92271584,"title":"In Vitro Antimalarial Drug Susceptibility and PFCRT Mutation Among Fresh Plasmodium Falciparum Isolates from the Lao PDR (Laos)","internal_url":"https://www.academia.edu/92271584/In_Vitro_Antimalarial_Drug_Susceptibility_and_PFCRT_Mutation_Among_Fresh_Plasmodium_Falciparum_Isolates_from_the_Lao_PDR_Laos_","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92271581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92271581/An_open_randomized_comparison_of_artesunate_plus_mefloquine_vs_dihydroartemisinin_piperaquine_for_the_treatment_of_uncomplicated_Plasmodium_falciparum_malaria_in_the_Lao_Peoples_Democratic_Republic_Laos_"><img alt="Research paper thumbnail of An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)" class="work-thumbnail" src="https://attachments.academia-assets.com/95324159/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92271581/An_open_randomized_comparison_of_artesunate_plus_mefloquine_vs_dihydroartemisinin_piperaquine_for_the_treatment_of_uncomplicated_Plasmodium_falciparum_malaria_in_the_Lao_Peoples_Democratic_Republic_Laos_">An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)</a></div><div class="wp-workCard_item"><span>Tropical Medicine and International Health</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">objective To determine the efficacy and safety of oral dihydroartemisinin-piperaquine (DP, Arteki...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">objective To determine the efficacy and safety of oral dihydroartemisinin-piperaquine (DP, Artekin TM) in the treatment of uncomplicated Plasmodium falciparum malaria in southern Laos. methods An open, randomized clinical trial of oral artesunate-mefloquine (AM) vs. DP in 220 patients with acute uncomplicated falciparum malaria in Savannakhet Province, Laos. results The 42-day cure rates (95% CI), as determined by survival analysis and adjusted for reinfection, were excellent and similar for the two groups [99 (94-100)% and 100 (100-100)% for AM and DP, respectively]. The median (range) fever and parasite clearance times for the AM and DP groups were also similar [20 (4-63) h and 2 (1-4) days vs. 20 (7-57) and 2 (1-4) days, logrank P ¼ 0.4 and 0.17, respectively]. There were more patients with at least one potential side effect following treatment in the AM group when compared with the DP group [64/110 (58%) vs. 48/110 (44%), respectively, P ¼ 0.031]. conclusion Dihydroartemisinin-piperaquine did not have superior efficacy to AM for the treatment of uncomplicated falciparum malaria in Laos but was associated with fewer adverse effects.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d54aaf2b200fe6aa4fbc1fe133ea37ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95324159,"asset_id":92271581,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95324159/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92271581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92271581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92271581; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92271581]").text(description); $(".js-view-count[data-work-id=92271581]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92271581; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92271581']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d54aaf2b200fe6aa4fbc1fe133ea37ec" } } $('.js-work-strip[data-work-id=92271581]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92271581,"title":"An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)","internal_url":"https://www.academia.edu/92271581/An_open_randomized_comparison_of_artesunate_plus_mefloquine_vs_dihydroartemisinin_piperaquine_for_the_treatment_of_uncomplicated_Plasmodium_falciparum_malaria_in_the_Lao_Peoples_Democratic_Republic_Laos_","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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Th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/− clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="65c89cc41602df7fcf11a40bd8959980" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95324142,"asset_id":92271567,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95324142/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92271567"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92271567"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92271567; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92271567]").text(description); $(".js-view-count[data-work-id=92271567]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92271567; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92271567']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "65c89cc41602df7fcf11a40bd8959980" } } $('.js-work-strip[data-work-id=92271567]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92271567,"title":"Dihydroartemisinin—Piperaquine Rescue Treatment of Multidrug-resistant Plasmodium falciparum Malaria in Pregnancy: A Preliminary Report","internal_url":"https://www.academia.edu/92271567/Dihydroartemisinin_Piperaquine_Rescue_Treatment_of_Multidrug_resistant_Plasmodium_falciparum_Malaria_in_Pregnancy_A_Preliminary_Report","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[{"id":95324142,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/95324142/thumbnails/1.jpg","file_name":"66ab9f7ec6993dc5871e9ca55a458635fcbf.pdf","download_url":"https://www.academia.edu/attachments/95324142/download_file","bulk_download_file_name":"Dihydroartemisinin_Piperaquine_Rescue_Tr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/95324142/66ab9f7ec6993dc5871e9ca55a458635fcbf-libre.pdf?1670318286=\u0026response-content-disposition=attachment%3B+filename%3DDihydroartemisinin_Piperaquine_Rescue_Tr.pdf\u0026Expires=1740544799\u0026Signature=YS4lsO-IfChR4Tqr21gV4X0ayviLNoLfQC5RIVDQXl-Dt61odgkmAUT6OKu4bSBskD0~ZCpwNEaxDV0av3eDEuvmNJ8gnsAO1j~GVENUubc7SXCIh-mv8FZs8fhI0bGQXzs5t3uuh2YWG0NQZ7clY6tF8NgvvVr5Q7cby2HTVAO~TzZGh9t6sybPt62LS28HOuesJ0XutLC-K8rRzSnRWn-vKYcd6Sgfedd2HEOW0eTTJ1q4UAabk0-Fh8XVFQVpqniBh~154lM8ETBCZUYmZtoFShOzTQX8MD8Da0oyfdT6MWyvTk5jPUnL1EDZyuMp7J2vY1UY3U7FdJ0m4ucLYg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3814292" id="papers"><div class="js-work-strip profile--work_container" data-work-id="124445142"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124445142/Early_detection_of_myocardial_dysfunction_in_children_with_beta_thalassaemia_major"><img alt="Research paper thumbnail of Early detection of myocardial dysfunction in children with beta-thalassaemia major" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124445142/Early_detection_of_myocardial_dysfunction_in_children_with_beta_thalassaemia_major">Early detection of myocardial dysfunction in children with beta-thalassaemia major</a></div><div class="wp-workCard_item"><span>The International Journal of Cardiovascular Imaging</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate left and right ventricular myocardial performance using pulsed-tissue Doppler imaging...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate left and right ventricular myocardial performance using pulsed-tissue Doppler imaging (TDI) and its relation to BNP levels in patients with beta-thalassaemia major (beta-TM). We enrolled 36 thalassaemic patients (21 male, 15 female; mean age: 14.2 +/- 4.1 years) with normal left ventricular systolic and diastolic functions with conventional echocardiography and 30 healthy control subjects (18 male, 12 female, and 12.5 +/- 4.2 years). Myocardial performance indexes (MPI) of left ventricular (LV) lateral wall, interventricular septum (IVS) and right ventricular (RV) lateral wall were calculated with TDI. Plasma BNP levels were measured in all patients. MPIs and other echocardiographic parameters of patients with beta-TM were compared with control group. All the patients&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; plasma BNP levels were within normal limits. There were no differences between conventional echocardiographic parameters of patients and control group. MPI of LV, IVS, and RV of patients were significantly higher than control group (P = 0.01, and P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01, and P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, respectively). Our study confirms that MPI obtained by TDI seems to be an early sensitive parameter of cardiac dysfunction in beta-TM. We concluded that MPI obtained by TDI may be an adjunctive parameter to conventional echocardiography for detecting early myocardial damage.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124445142"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124445142"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124445142; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124445142]").text(description); $(".js-view-count[data-work-id=124445142]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124445142; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124445142']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124445142]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124445142,"title":"Early detection of myocardial dysfunction in children with beta-thalassaemia major","internal_url":"https://www.academia.edu/124445142/Early_detection_of_myocardial_dysfunction_in_children_with_beta_thalassaemia_major","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124445140"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124445140/A_new_insertion_sequence_IS_element_of_Streptococcus_pneumoniae_and_its_application_for_the_surveillance_of_penicillin_resistant_pneumococci"><img alt="Research paper thumbnail of A new insertion sequence (IS) element of Streptococcus pneumoniae and its application for the surveillance of penicillin resistant pneumococci" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/124445140/A_new_insertion_sequence_IS_element_of_Streptococcus_pneumoniae_and_its_application_for_the_surveillance_of_penicillin_resistant_pneumococci">A new insertion sequence (IS) element of Streptococcus pneumoniae and its application for the surveillance of penicillin resistant pneumococci</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124445140"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124445140"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124445140; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124445140]").text(description); $(".js-view-count[data-work-id=124445140]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124445140; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124445140']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124445140]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124445140,"title":"A new insertion sequence (IS) element of Streptococcus pneumoniae and its application for the surveillance of penicillin resistant pneumococci","internal_url":"https://www.academia.edu/124445140/A_new_insertion_sequence_IS_element_of_Streptococcus_pneumoniae_and_its_application_for_the_surveillance_of_penicillin_resistant_pneumococci","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827621"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827621/Considerations_on_the_use_of_nucleic_acid_based_amplification_for_malaria_parasite_detection"><img alt="Research paper thumbnail of Considerations on the use of nucleic acid-based amplification for malaria parasite detection" class="work-thumbnail" src="https://attachments.academia-assets.com/104452504/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827621/Considerations_on_the_use_of_nucleic_acid_based_amplification_for_malaria_parasite_detection">Considerations on the use of nucleic acid-based amplification for malaria parasite detection</a></div><div class="wp-workCard_item"><span>Malaria Journal</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Nucleic acid amplification provides the most sensitive and accurate method to detect a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Nucleic acid amplification provides the most sensitive and accurate method to detect and identify pathogens. This is primarily useful for epidemiological investigations of malaria because the infections, often with two or more Plasmodium species present simultaneously, are frequently associated with microscopically sub-patent parasite levels and cryptic mixed infections. Numerous distinct equally adequate amplification-based protocols have been described, but it is unclear which to select for epidemiological surveys. Few comparative studies are available, and none that addresses the issue of inter-laboratory variability. Methods Blood samples were collected from patients attending malaria clinics on the Thai-Myanmar border. Frozen aliquots from 413 samples were tested independently in two laboratories by nested PCR assay. Dried blood spots on filter papers from the same patients were also tested by the nested PCR assay in one laboratory and by a multiplex PCR assay in ano...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="99c9e7a0e4dce77b516fa97e03b493ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452504,"asset_id":104827621,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452504/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827621"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827621"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827621; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827621]").text(description); $(".js-view-count[data-work-id=104827621]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827621; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827621']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "99c9e7a0e4dce77b516fa97e03b493ee" } } $('.js-work-strip[data-work-id=104827621]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827621,"title":"Considerations on the use of nucleic acid-based amplification for malaria parasite detection","internal_url":"https://www.academia.edu/104827621/Considerations_on_the_use_of_nucleic_acid_based_amplification_for_malaria_parasite_detection","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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Dihydroartemisinin-piperaquine (DP) is a fixed-combination antimalarial drug increasi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Dihydroartemisinin-piperaquine (DP) is a fixed-combination antimalarial drug increasingly deployed in Southeast Asia. The current regimen involves 4 doses given over 3 days. Simplification of the dose regimen should facilitate treatment adherence and thereby increase effectiveness. Methods. In a randomized, controlled, 3-arm trial conducted along the northwestern border of Thailand, the standard 4-dose course of DP (DP4) was compared to an equivalent dose given as a once-daily regimen (DP3) and to the standard treatment of mefloquine-artesunate (MAS3). Results. A total of 499 patients were included in the study. Times to fever and parasite clearance were similar in all groups. The PCR genotyping-adjusted cure rates at day 63 after treatment initiation were 95.7% (95% confidence interval [95% CI], 92.2%-98.9%) for MAS3, 100% for DP4, and 99.4% (95% CI, 98.1%-100%) for DP3. The DP4 and DP3 cure rates were significantly higher than that for MAS3 (and , respectively). P p .008 P p .03 All regimens were well tolerated. There were 3 deaths (1 in the MAS3 group and 2 in the DP3 group), all of which were considered to be unrelated to treatment. Rates of other adverse events were comparable between the groups, except for diarrhea, which was more common in the DP4 group (vs. the MAS3 group). P p .05 Conclusions. A once-daily, 3-dose regimen of DP is a highly efficacious treatment for multidrug-resistant falciparum malaria. This simple, safe, and relatively inexpensive fixed combination could become the treatment of choice for falciparum malaria. Dihydroartemisinin-piperaquine (DP) is an artemisinin-containing, fixed-combination antimalarial drug developed in China. Recent randomized clinical trials in Cambodia, Vietnam, and Thailand indicate excellent tolerability and high cure rates against multidrugresistant falciparum malaria [1-3]. DP is being used increasingly in Southeast Asia and is already part of national treatment recommendations in Cambodia and Vietnam. Dihydroartemisinin is a highly active artemisinin de</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1352227db568e28028e6792770040fee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452505,"asset_id":104827619,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452505/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827619"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827619"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827619; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827619]").text(description); $(".js-view-count[data-work-id=104827619]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827619; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827619']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1352227db568e28028e6792770040fee" } } $('.js-work-strip[data-work-id=104827619]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827619,"title":"A Randomized, Controlled Study of a Simple, Once-Daily Regimen of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated, Multidrug-Resistant Falciparum Malaria","internal_url":"https://www.academia.edu/104827619/A_Randomized_Controlled_Study_of_a_Simple_Once_Daily_Regimen_of_Dihydroartemisinin_Piperaquine_for_the_Treatment_of_Uncomplicated_Multidrug_Resistant_Falciparum_Malaria","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[{"id":104452505,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104452505/thumbnails/1.jpg","file_name":"41-4-425.pdf","download_url":"https://www.academia.edu/attachments/104452505/download_file","bulk_download_file_name":"A_Randomized_Controlled_Study_of_a_Simpl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104452505/41-4-425-libre.pdf?1690062836=\u0026response-content-disposition=attachment%3B+filename%3DA_Randomized_Controlled_Study_of_a_Simpl.pdf\u0026Expires=1740544799\u0026Signature=alcC0cVrlABKAuXmmFYrSUKt~FAGJEDefDeWd-YetRDls56XcYMUh3SwSXKaJyr84uSRuegeR7UWuTf0ODeQuAVa67HzHf3u0DnKK0T0fF1cm5-kOKK-Rt2mftcPHnL-3TGOFJiRAitGUdbaQNUgf7sxC0Re8CvrijcL3tr5oOcAw02a0uedDZzzY09cKlmIjy6pIgYroEmyiqNS6Qv3P7hDuM4FWJpfq7W4UIoKx5F1HsR6OhNobAeuUhqBXcp5kCFuy0DHUXFbwUll6uod3yK~M2VAJCGm-uFeEVM3D2YdTsYj6mz7P-DAfoIxHGwKbyuzUsrNVMP~pMVcD4XIfQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827618"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104827618/Influence_of_respiratory_syncytial_virus_infection_on_cytokine_and_inflammatory_responses_in_allergic_mice"><img alt="Research paper thumbnail of Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104827618/Influence_of_respiratory_syncytial_virus_infection_on_cytokine_and_inflammatory_responses_in_allergic_mice">Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice</a></div><div class="wp-workCard_item"><span>Clinical &amp; Experimental Allergy</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Th2 lymphocyte responses are associated with inflammation and disease during allergic responses. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Th2 lymphocyte responses are associated with inflammation and disease during allergic responses. Exposure to particular environmental factors during the expression of allergy could result in more pronounced Th2-like immune responses and more severe disease. One factor might be a respiratory virus infection. The aim of our study was to investigate the influence of respiratory syncytial virus (RSV) infection on the expression of ovalbumin (OVA)-induced allergy in BALB/c mice. We determined OVA-specific IgE in serum, cytokine profiles and histopathological lesions in lungs of OVA-allergic mice after RSV infection. OVA sensitization and challenge induced OVA-specific IgE in serum, Th2 cytokine mRNA expression, and mononuclear and eosinophilic inflammation in the lungs. RSV inoculation during the challenge period enhanced OVA-induced IL-4 and IL-5 mRNA expression in lung tissue. RSV further enhanced the OVA-induced hypertrophy of mucous cells and eosinophilic infiltration in lung tissue. Surprisingly, RSV infection decreased Th2 cytokine secretion and eosinophilic influx in bronchoalveolar lavage of OVA-allergic mice. Because inactivated RSV did not influence these responses, replication of RSV appeared essential for the modification of OVA-induced Th2 cytokine expression. RSV did not change OVA-specific IgE levels in serum. Furthermore, the RSV-induced IL-12 mRNA expression in lung tissue of OVA-allergic mice was diminished, but IFN-gamma mRNA expression was not affected. RSV infection enhanced particular OVA-induced Th2 cytokine mRNA responses and pulmonary lesions in allergic mice and thus aggravated allergic respiratory disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827618"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827618"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827618; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827618]").text(description); $(".js-view-count[data-work-id=104827618]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827618; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827618']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104827618]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827618,"title":"Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice","internal_url":"https://www.academia.edu/104827618/Influence_of_respiratory_syncytial_virus_infection_on_cytokine_and_inflammatory_responses_in_allergic_mice","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827614"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827614/In_vitro_activity_of_ferroquine_SSR_97193_against_Plasmodium_falciparum_isolates_from_the_Thai_Burmese_border"><img alt="Research paper thumbnail of In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border" class="work-thumbnail" src="https://attachments.academia-assets.com/104452499/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827614/In_vitro_activity_of_ferroquine_SSR_97193_against_Plasmodium_falciparum_isolates_from_the_Thai_Burmese_border">In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border</a></div><div class="wp-workCard_item"><span>Malaria Journal</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background On the borders of Thailand, Plasmodium falciparum has become resistant to nearly all a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background On the borders of Thailand, Plasmodium falciparum has become resistant to nearly all available drugs, and there is an urgent need to find new antimalarial drugs or drug combinations. Ferroquine (SSR97193) is a new 4-aminoquinoline antimalarial active against chloroquine resistant and sensitive P. falciparum strains in vivo and in vitro. This antimalarial organic iron complex (a ferrocenyl group has been associated with chloroquine) is meant to use the affinity of Plasmodium for iron to increase the probability for encountering the anti-malarial molecule. The aim of the present study was to investigate the activity of ferroquine against P. falciparum isolates from an area with a known high multi-drug resistance rate. Methods Parasite isolates were obtained from patients with acute falciparum malaria attending the clinics of SMRU. In vitro cultures of these isolates were set-up in the SMRU-laboratory on pre-dosed drug plates, and grown in culture for 42 hours. Parasite grow...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d3b2ea9b2ed8df25f5fe16064c96cb3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452499,"asset_id":104827614,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452499/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827614"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827614"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827614; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827614]").text(description); $(".js-view-count[data-work-id=104827614]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827614; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827614']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1d3b2ea9b2ed8df25f5fe16064c96cb3" } } $('.js-work-strip[data-work-id=104827614]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827614,"title":"In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border","internal_url":"https://www.academia.edu/104827614/In_vitro_activity_of_ferroquine_SSR_97193_against_Plasmodium_falciparum_isolates_from_the_Thai_Burmese_border","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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An important first step is to determine trait heritability ( H 2 ). We evaluate two approaches to measuring H 2 in natural parasite populations using relatedness inferred from genetic marker data. We collected single-clone Plasmodium falciparum infections from 185 patients from the Thailand–Burma border, monitored parasite clearance following treatment with artemisinin combination therapy (ACT), measured resistance to six antimalarial drugs and genotyped parasites using 335 microsatellites. We found strong relatedness structure. There were 27 groups of two to eight clonally identical (CI) parasites, and 74 per cent of parasites showed significant relatedness to one or more other parasites. Initially, we used matrices of allele sharing and variance compo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="760e0de9b11cdfbda5ca649fc88b3507" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452498,"asset_id":104827613,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452498/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827613"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827613"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827613; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827613]").text(description); $(".js-view-count[data-work-id=104827613]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827613; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827613']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "760e0de9b11cdfbda5ca649fc88b3507" } } $('.js-work-strip[data-work-id=104827613]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827613,"title":"Inferred relatedness and heritability in malaria parasites","internal_url":"https://www.academia.edu/104827613/Inferred_relatedness_and_heritability_in_malaria_parasites","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[{"id":104452498,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104452498/thumbnails/1.jpg","file_name":"rspb.2010.pdf","download_url":"https://www.academia.edu/attachments/104452498/download_file","bulk_download_file_name":"Inferred_relatedness_and_heritability_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104452498/rspb.2010-libre.pdf?1690062845=\u0026response-content-disposition=attachment%3B+filename%3DInferred_relatedness_and_heritability_in.pdf\u0026Expires=1740544799\u0026Signature=Nnu~dDTD~xbyeAZ5YQuUXwkXb26tp35oUWho0qGu6mRYZiuLUyvKSTNMu7cM~OOC~oPYpyIzCjDZUVIfAoUWC8D-SN-5KvEQGRDEvUAwRCMBe0Gh40EeL0D0dG3eupQFI4~2MfGSXV~nPUlwJHu0dxnuRpiQqXnFQlOtJN89STWb7CCwBitpdHAAKKhGXx-3JwyVsDJFNdMNmeikP8dZSXk9QtgSdPMRVKFEyHJ9GVrcv009QOz8srlYREGFPWmylqgaBBOYMTOa5JlSkPg2bRDjQdQDe-l~Q1dAxTGian6xD~DYSL66Nve8ezFhSsAYE8pCaVM~AD0omPWt3QkYaQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827612"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/104827612/Chloroquine_Resistant_Plasmodium_vivax_In_Vitro_Characterisation_and_Association_with_Molecular_Polymorphisms"><img alt="Research paper thumbnail of Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/104827612/Chloroquine_Resistant_Plasmodium_vivax_In_Vitro_Characterisation_and_Association_with_Molecular_Polymorphisms">Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms</a></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827612"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827612"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827612; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827612]").text(description); $(".js-view-count[data-work-id=104827612]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827612; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827612']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104827612]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827612,"title":"Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms","internal_url":"https://www.academia.edu/104827612/Chloroquine_Resistant_Plasmodium_vivax_In_Vitro_Characterisation_and_Association_with_Molecular_Polymorphisms","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827611"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827611/Amplification_ofpvmdr1Associated_with_Multidrug_ResistantPlasmodium_vivax"><img alt="Research paper thumbnail of Amplification ofpvmdr1Associated with Multidrug‐ResistantPlasmodium vivax" class="work-thumbnail" src="https://attachments.academia-assets.com/104452497/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827611/Amplification_ofpvmdr1Associated_with_Multidrug_ResistantPlasmodium_vivax">Amplification ofpvmdr1Associated with Multidrug‐ResistantPlasmodium vivax</a></div><div class="wp-workCard_item"><span>The Journal of Infectious Diseases</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia. Metho...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia. Methods. In vitro drug susceptibility and pvmdr1 genotype were determined in P. vivax field isolates from Indonesia and Thailand. Results. Increased pvmdr1 copy number was present in 21% of isolates from Thailand (15/71) and none from Indonesia (0/114; P Ͻ .001). Compared with Indonesian isolates, the median IC 50 of Thai isolates was lower for chloroquine (36 vs. 114 nmol/L; P Ͻ .001) but higher for amodiaquine (34 vs. 13.7 nmol/L; P ϭ .032), artesunate (8.33 vs. 1.58 nmol/L; P Ͻ .001), and mefloquine (111 vs. 9.87 nmol/L; P Ͻ .001). In 11 cryopreserved Thai isolates, those with increased pvmdr1 copy number had a higher IC 50 for mefloquine (78.6 vs. 38 nmol/L for single-copy isolates; P ϭ .006). Compared with isolates with the wild-type allele, the Y976F mutation of pvmdr1 was associated with reduced susceptibility to chloroquine (154 nmol/L [range, 4.6-3505] vs. 34 nmol/L [range, 6.7-149]; P Ͻ .001) but greater susceptibility to artesunate (1.8 vs. 9.5 nmol/L; P ϭ .009) and mefloquine (14 vs. 121 nmol/L; P Ͻ .001). Conclusions. Amplification of pvmdr1 and single-nucleotide polymorphisms are correlated with susceptibility of P. vivax to multiple antimalarial drugs. Chloroquine and mefloquine appear to exert competitive evolutionary pressure on pvmdr1, similar to that observed with pfmdr1 in Plasmodium falciparum.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e1b061de0502908a03e55bd757fe70f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452497,"asset_id":104827611,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452497/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827611"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827611"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827611; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827611]").text(description); $(".js-view-count[data-work-id=104827611]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827611; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827611']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e1b061de0502908a03e55bd757fe70f3" } } $('.js-work-strip[data-work-id=104827611]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827611,"title":"Amplification ofpvmdr1Associated with Multidrug‐ResistantPlasmodium vivax","internal_url":"https://www.academia.edu/104827611/Amplification_ofpvmdr1Associated_with_Multidrug_ResistantPlasmodium_vivax","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[{"id":104452497,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/104452497/thumbnails/1.jpg","file_name":"198-10-1558.pdf","download_url":"https://www.academia.edu/attachments/104452497/download_file","bulk_download_file_name":"Amplification_ofpvmdr1Associated_with_Mu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/104452497/198-10-1558-libre.pdf?1690062845=\u0026response-content-disposition=attachment%3B+filename%3DAmplification_ofpvmdr1Associated_with_Mu.pdf\u0026Expires=1740544799\u0026Signature=gWqgR66of58AIBO1RaDUztHsqwWX3ARh~P6Au2eK~6z29eUphWq7Y~PoadDNj9zYwWwQf9drxyZc326iUnL1wq7aRSKsmvsA-2A0JxWnfz4VPJzkhMUZikDbA4ThJb35-xFCJjRzjPf~3j0QSk3ltEHFCKkCONON5D4m5RdzSX8WobrBfs-GnwKzszxabFf1I-O~z7~gaL9oaYP1Zz9rB1mBGvvohPB1nZHrYc3Mk~SZ4AewXUhYJx3vrEc4sI9A7yBnvcWl5QhXO6xiWKTopRFw993gFzp9E7HcohEegcfshhaVlm8auAO4oEN0cCIIIND6tllIfipu99JV912GgA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827610"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827610/A_Randomized_Comparison_of_Artesunate_Atovaquone_Proguanil_versus_Quinine_in_Treatment_for_Uncomplicated_Falciparum_Malaria_during_Pregnancy"><img alt="Research paper thumbnail of A Randomized Comparison of Artesunate‐Atovaquone‐Proguanil versus Quinine in Treatment for Uncomplicated Falciparum Malaria during Pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/104452495/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827610/A_Randomized_Comparison_of_Artesunate_Atovaquone_Proguanil_versus_Quinine_in_Treatment_for_Uncomplicated_Falciparum_Malaria_during_Pregnancy">A Randomized Comparison of Artesunate‐Atovaquone‐Proguanil versus Quinine in Treatment for Uncomplicated Falciparum Malaria during Pregnancy</a></div><div class="wp-workCard_item"><span>The Journal of Infectious Diseases</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. There is no safe, practical, and effective treatment for pregnant women infected with...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. There is no safe, practical, and effective treatment for pregnant women infected with multidrugresistant Plasmodium falciparum. Methods. We recruited pregnant Karen women in the second or third trimesters of pregnancy who had uncomplicated falciparum malaria for a randomized, open-label trial with a restricted sequential trial design of 7 days of supervised quinine (SQ7) versus 3 days of artesunate-atovaquone-proguanil (AAP). Results. Eight-one pregnant women entered the study between December 2001 and July 2003; 42 were treated with SQ7 and 39 were treated with AAP. Fever, parasite clearance, and duration of anemia were significantly better with AAP; the treatment failure rate was 7 times lower (5% [2/39] vs. 37% [15/41]; relative risk, 7.1 [95% confidence interval, 1.7-29.2];). There were no significant differences in birth weight, duration of gestation, or P p .001 congenital abnormality rates in newborns or in growth and developmental parameters of infants monitored for 1 year. Conclusion. AAP is a well-tolerated, effective, practical, but expensive treatment for multidrug-resistant falciparum malaria during the second or third trimesters of pregnancy. Despite the small number of subjects, our results add to the growing body of evidence that AAP is safe for the mother and the fetus. Plasmodium falciparum infection during pregnancy has deleterious consequences for both mother and fetus; in low-transmission settings, it is potentially lethal [1]. There are few safe and effective therapeutic options during pregnancy. Concerns about fetal toxicity have caused researchers to exclude pregnant and lactating women from antimalarial drug trials. Quinine is considered to be safe during all trimesters of pregnancy, and it is widely recommended as a treatment, although adverse effects are common and adherence is poor. New drugs are needed, but the pharmaceutical industry is</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b4cc942bf6029e6e462df5dd132227c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452495,"asset_id":104827610,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452495/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827610"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827610"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827610; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827610]").text(description); $(".js-view-count[data-work-id=104827610]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827610; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827610']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b4cc942bf6029e6e462df5dd132227c5" } } $('.js-work-strip[data-work-id=104827610]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827610,"title":"A Randomized Comparison of Artesunate‐Atovaquone‐Proguanil versus Quinine in Treatment for Uncomplicated Falciparum Malaria during Pregnancy","internal_url":"https://www.academia.edu/104827610/A_Randomized_Comparison_of_Artesunate_Atovaquone_Proguanil_versus_Quinine_in_Treatment_for_Uncomplicated_Falciparum_Malaria_during_Pregnancy","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P . vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P . vivax malaria.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827609"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827609"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827609; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827609]").text(description); $(".js-view-count[data-work-id=104827609]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827609; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827609']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104827609]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827609,"title":"Plasmodium vivax Susceptibility to Ferroquine","internal_url":"https://www.academia.edu/104827609/Plasmodium_vivax_Susceptibility_to_Ferroquine","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104827602"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104827602/Efficacy_and_effectiveness_of_dihydroartemisinin_piperaquine_versus_artesunate_mefloquine_in_falciparum_malaria_an_open_label_randomised_comparison"><img alt="Research paper thumbnail of Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison" class="work-thumbnail" src="https://attachments.academia-assets.com/104452508/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104827602/Efficacy_and_effectiveness_of_dihydroartemisinin_piperaquine_versus_artesunate_mefloquine_in_falciparum_malaria_an_open_label_randomised_comparison">Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison</a></div><div class="wp-workCard_item"><span>The Lancet</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Artemisinin-based combinations are judged the best treatments for multidrug-resistant ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Artemisinin-based combinations are judged the best treatments for multidrug-resistant Plasmodium falciparum malaria. Artesunate-mefl oquine is widely recommended in southeast Asia, but its high cost and tolerability profi le remain obstacles to widespread deployment. To assess whether dihydroartemisinin-piperaquine is a suitable alternative to artesunate-mefl oquine, we compared the safety, tolerability, effi cacy, and eff ectiveness of the two regimens for the treatment of uncomplicated falciparum in western Myanmar (Burma). Methods We did an open randomised comparison of 3-day regimens of artesunate-mefl oquine (12/25 mg/kg) versus dihydroartemisinin-piperaquine (6•3/50 mg/kg) for the treatment of children aged 1 year or older and in adults with uncomplicated falciparum malaria in Rakhine State, western Myanmar. Within each group, patients were randomly assigned supervised or non-supervised treatment. The primary endpoint was the PCR-confi rmed parasitological failure rate by day 42. Failure rates at day 42 were estimated by Kaplan-Meier survival analysis. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN27914471. Findings Of 652 patients enrolled, 327 were assigned dihydroartemisinin-piperaquine (156 supervised and 171 not supervised), and 325 artesunate-mefl oquine (162 and 163, respectively). 16 patients were lost to follow-up, and one patient died 22 days after receiving dihydroartemisinin-piperaquine. Recrudescent parasitaemias were confi rmed in only two patients; the day 42 failure rate was 0•6% (95% CI 0•2-2•5) for dihydroartemisinin-piperaquine and 0 (0-1•2) for artesunate-mefl oquine. Whole-blood piperaquine concentrations at day 7 were similar for patients with observed and non-observed dihydroartemisinin-piperaquine treatment. Gametocytaemia developed more frequently in patients who had received dihydroartemisinin-piperaquine than in those on artesunate-mefl oquine: day 7, 18 (10%) of 188 versus fi ve (2%) of 218; relative risk 4•2 (1•6-11•0) p=0•011. Interpretation Dihydroartemisinin-piperaquine is a highly effi cacious and inexpensive treatment of multidrugresistant falciparum malaria and is well tolerated by all age groups. The eff ectiveness of the unsupervised treatment, as in the usual context of use, equalled its supervised effi cacy, indicating good adherence without supervision. Dihydroartemisinin-piperaquine is a good alternative to artesunate-mefl oquine.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="07b3ae4c85209545fd73953dc2b1ae5b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":104452508,"asset_id":104827602,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/104452508/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104827602"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104827602"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104827602; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104827602]").text(description); $(".js-view-count[data-work-id=104827602]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104827602; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104827602']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "07b3ae4c85209545fd73953dc2b1ae5b" } } $('.js-work-strip[data-work-id=104827602]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104827602,"title":"Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison","internal_url":"https://www.academia.edu/104827602/Efficacy_and_effectiveness_of_dihydroartemisinin_piperaquine_versus_artesunate_mefloquine_in_falciparum_malaria_an_open_label_randomised_comparison","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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We used the double-site enzyme-linked pLDH immunodetection (DELI) assay to estimate the in vitro antimalarial drug susceptibility of 108 fresh P. falciparum isolates from southern Laos. The geometric mean (95% confidence interval) 50% inhibitory concentration values (nmol/L) were 152.4 (123.8-187.6) for chloroquine, 679.8 (533.8-863.0) for quinine, 45.9 (37.9-55.7) for mefloquine, 5.0 (4.4-6.4) for artesunate, 6.3 (4.5-8.9) for dihydroartemisinin, and 59.1 (46.4-75.3) for lumefantrine. The proportion of isolates defined as resistant were 65%, 40%, and 8% for chloroquine, quinine, and mefloquine, respectively. Of 53 isolates genotyped for the pfcrt T76K chloroquine-resistance mutation, 48 (91%) were mutants. P. falciparum in Laos is multi-drug resistant; antimalarial immunity resulting from the use of ineffective chloroquine before 2005 probably contributes significantly to the therapeutic responses in clinical trials.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c9ec39925806232438442bdf7d9270dd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95324160,"asset_id":92271584,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95324160/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92271584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92271584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92271584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92271584]").text(description); $(".js-view-count[data-work-id=92271584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92271584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92271584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c9ec39925806232438442bdf7d9270dd" } } $('.js-work-strip[data-work-id=92271584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92271584,"title":"In Vitro Antimalarial Drug Susceptibility and PFCRT Mutation Among Fresh Plasmodium Falciparum Isolates from the Lao PDR (Laos)","internal_url":"https://www.academia.edu/92271584/In_Vitro_Antimalarial_Drug_Susceptibility_and_PFCRT_Mutation_Among_Fresh_Plasmodium_Falciparum_Isolates_from_the_Lao_PDR_Laos_","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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Barends","url":"https://independent.academia.edu/MBarends"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="92271581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/92271581/An_open_randomized_comparison_of_artesunate_plus_mefloquine_vs_dihydroartemisinin_piperaquine_for_the_treatment_of_uncomplicated_Plasmodium_falciparum_malaria_in_the_Lao_Peoples_Democratic_Republic_Laos_"><img alt="Research paper thumbnail of An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)" class="work-thumbnail" src="https://attachments.academia-assets.com/95324159/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/92271581/An_open_randomized_comparison_of_artesunate_plus_mefloquine_vs_dihydroartemisinin_piperaquine_for_the_treatment_of_uncomplicated_Plasmodium_falciparum_malaria_in_the_Lao_Peoples_Democratic_Republic_Laos_">An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)</a></div><div class="wp-workCard_item"><span>Tropical Medicine and International Health</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">objective To determine the efficacy and safety of oral dihydroartemisinin-piperaquine (DP, Arteki...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">objective To determine the efficacy and safety of oral dihydroartemisinin-piperaquine (DP, Artekin TM) in the treatment of uncomplicated Plasmodium falciparum malaria in southern Laos. methods An open, randomized clinical trial of oral artesunate-mefloquine (AM) vs. DP in 220 patients with acute uncomplicated falciparum malaria in Savannakhet Province, Laos. results The 42-day cure rates (95% CI), as determined by survival analysis and adjusted for reinfection, were excellent and similar for the two groups [99 (94-100)% and 100 (100-100)% for AM and DP, respectively]. The median (range) fever and parasite clearance times for the AM and DP groups were also similar [20 (4-63) h and 2 (1-4) days vs. 20 (7-57) and 2 (1-4) days, logrank P ¼ 0.4 and 0.17, respectively]. There were more patients with at least one potential side effect following treatment in the AM group when compared with the DP group [64/110 (58%) vs. 48/110 (44%), respectively, P ¼ 0.031]. conclusion Dihydroartemisinin-piperaquine did not have superior efficacy to AM for the treatment of uncomplicated falciparum malaria in Laos but was associated with fewer adverse effects.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d54aaf2b200fe6aa4fbc1fe133ea37ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95324159,"asset_id":92271581,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95324159/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92271581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92271581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92271581; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92271581]").text(description); $(".js-view-count[data-work-id=92271581]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92271581; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92271581']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d54aaf2b200fe6aa4fbc1fe133ea37ec" } } $('.js-work-strip[data-work-id=92271581]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92271581,"title":"An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)","internal_url":"https://www.academia.edu/92271581/An_open_randomized_comparison_of_artesunate_plus_mefloquine_vs_dihydroartemisinin_piperaquine_for_the_treatment_of_uncomplicated_Plasmodium_falciparum_malaria_in_the_Lao_Peoples_Democratic_Republic_Laos_","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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Th...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/− clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="65c89cc41602df7fcf11a40bd8959980" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":95324142,"asset_id":92271567,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/95324142/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="92271567"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="92271567"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 92271567; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=92271567]").text(description); $(".js-view-count[data-work-id=92271567]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 92271567; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='92271567']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "65c89cc41602df7fcf11a40bd8959980" } } $('.js-work-strip[data-work-id=92271567]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":92271567,"title":"Dihydroartemisinin—Piperaquine Rescue Treatment of Multidrug-resistant Plasmodium falciparum Malaria in Pregnancy: A Preliminary Report","internal_url":"https://www.academia.edu/92271567/Dihydroartemisinin_Piperaquine_Rescue_Treatment_of_Multidrug_resistant_Plasmodium_falciparum_Malaria_in_Pregnancy_A_Preliminary_Report","owner_id":36732656,"coauthors_can_edit":true,"owner":{"id":36732656,"first_name":"M.","middle_initials":null,"last_name":"Barends","page_name":"MBarends","domain_name":"independent","created_at":"2015-10-22T01:05:50.381-07:00","display_name":"M. 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