CINXE.COM

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id="main" class="site-main"> <article id="post-11199" class="post-11199 page type-page status-publish has-post-thumbnail hentry"> <div class="entry-content"> <div id="block-block_a57164794ba4ea3b4633f778b112ae61" class="block block--video block--full-width block--video-overlay block--video-clip" style="height: 415px;"> <div class="bg bg--video"> <video autoplay="" muted="" playsinline="" loop="" src="https://www.adaptivebiotech.com/wp-content/uploads/2020/11/platform-loop.mp4"></video> <div class="overlay"></div> <div class="container"> <div class="acf-innerblocks-container"> <h2 class="wp-block-heading has-text-align-left has-white-color has-text-color" id="h-tcr-antigen-map">TCR Antigen Map</h2> </div> </div>  <button class="video-play-pause">Pause</button> </div>  </div> <div class="wp-block-group is-layout-constrained wp-block-group-is-layout-constrained"> <div style="height:60px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading has-text-align-center" id="h-discovery-of-tcr-based-signatures-across-disease-areas">Discovery of TCR-based signatures across disease areas</h2> </div> <div id="block-block_6dce6385ea3fa275dc6cf1f861fb9683" class="offset-header block block--content"> <div class="container"> <div class="offset-header__bg" style="background-image: url(https://www.adaptivebiotech.com/wp-content/uploads/2020/11/tcr_patternbackground.png);"></div> <div class="offset-header__inner-blocks"> <div class="acf-innerblocks-container"> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <figure class="wp-block-image aligncenter size-full is-style-desktop"><img decoding="async" width="500" height="66" src="https://adaptivebiotech.com/wp-content/uploads/2020/11/adaptivemicrosoft.png" alt="" class="wp-image-11372" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2020/11/adaptivemicrosoft.png 500w, https://www.adaptivebiotech.com/wp-content/uploads/2020/11/adaptivemicrosoft-300x40.png 300w" sizes="(max-width: 500px) 100vw, 500px" /></figure> <figure class="wp-block-image size-full is-style-mobile"><img decoding="async" width="186" height="155" src="https://adaptivebiotech.com/wp-content/uploads/2020/11/adaptivemicrosoftmobile.png" alt="" class="wp-image-11373"/></figure> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <p>Adaptive has partnered with Microsoft to map and decode the human immune system. Specialized cells of the adaptive immune system, T and B cells, constantly respond to infections and cancer. These same cells are also involved in different autoimmune disorders. By reading  and decoding the adaptive immune system, we aim to translate into the clinic the natural capability of the immune system to recognize and fight disease.</p> <p>We use the exquisite specificity of T-cell receptors (TCRs) to discover and validate T-cell signatures of disease鈥攆rom infectious diseases to autoimmune conditions and in the future, potentially to cancer. We do this by building a map that links trillions of TCRs with millions of disease antigens. Our goal is to make the diagnosis and monitoring of disease more accurate and reliable.</p> <p>By combining our proprietary immunosequencing technology, computational modeling, and machine learning capabilities, we are making significant advances in how we can better detect and treat disease. Our drug discovery capabilities allow us to discover and fully characterize immune receptors鈥擳CRs and antibodies鈥攖o develop as therapeutic products.</p> </div> </div </div> </div> <div class="wp-block-group alignwide is-style-default is-layout-constrained wp-block-group-is-layout-constrained"> <div style="height:60px" aria-hidden="true" class="wp-block-spacer"></div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-resized has-custom-border"><img decoding="async" src="https://adaptivebiotech.com/wp-content/uploads/2023/06/icon-autoimmune-disorders.webp" alt="" class="has-border-color wp-image-26745" style="border-color:#2154d75e;border-width:4px;border-radius:1000px;width:150px;height:150px" width="150" height="150" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-autoimmune-disorders.webp 659w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-autoimmune-disorders-300x300.webp 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-autoimmune-disorders-150x150.webp 150w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-autoimmune-disorders-260x260.webp 260w" sizes="(max-width: 150px) 100vw, 150px" /></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-extra-small-font-size" id="h-autoimmunedisorders">Autoimmune<br>disorders</h3> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-resized has-custom-border"><img loading="lazy" decoding="async" src="https://adaptivebiotech.com/wp-content/uploads/2023/06/icon-cancer.webp" alt="" class="has-border-color wp-image-26746" style="border-color:#2154d75e;border-width:4px;border-radius:1000px;width:150px;height:150px" width="150" height="150" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-cancer.webp 659w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-cancer-300x300.webp 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-cancer-150x150.webp 150w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-cancer-260x260.webp 260w" sizes="(max-width: 150px) 100vw, 150px" /></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-extra-small-font-size" id="h-cancer">Cancer</h3> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-resized has-custom-border"><img loading="lazy" decoding="async" src="https://adaptivebiotech.com/wp-content/uploads/2023/06/icon-infectious-diseases.webp" alt="" class="has-border-color wp-image-26747" style="border-color:#2154d75e;border-width:4px;border-radius:1000px;width:150px;height:150px" width="150" height="150" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-infectious-diseases.webp 659w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-infectious-diseases-300x300.webp 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-infectious-diseases-150x150.webp 150w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-infectious-diseases-260x260.webp 260w" sizes="(max-width: 150px) 100vw, 150px" /></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-extra-small-font-size" id="h-infectiousdiseases">Infectious<br>diseases</h3> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-resized has-custom-border"><img loading="lazy" decoding="async" src="https://adaptivebiotech.com/wp-content/uploads/2023/06/icon-neuro-disorders.webp" alt="" class="has-border-color wp-image-26748" style="border-color:#2154d75e;border-width:4px;border-radius:1000px;width:150px;height:150px" width="150" height="150" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-neuro-disorders.webp 659w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-neuro-disorders-300x300.webp 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-neuro-disorders-150x150.webp 150w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-neuro-disorders-260x260.webp 260w" sizes="(max-width: 150px) 100vw, 150px" /></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-extra-small-font-size" id="h-neurodegenerative-disorders">Neurodegenerative disorders</h3> </div> </div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading has-text-align-center" id="h-building-the-tcr-antigen-map-to-readhow-the-immune-system-fights-disease">Building the TCR-Antigen Map to Read<br>How the Immune System Fights Disease</h2> <div class="wp-block-group is-style-medium-width is-layout-constrained wp-block-group-is-layout-constrained"> <p class="has-text-align-center">Together with Microsoft, we are mapping TCRs to antigens at massive scale鈥攍inking trillions of TCRs with millions of clinically relevant antigens鈥攖o identify and validate disease signatures to improve diagnosis, monitoring, and treatment of many diseases.</p> <p class="has-text-align-center">This collaboration is a cornerstone of the Microsoft Healthcare NExT initiative. Together, we are focused on translating the biology of the adaptive immune system to better understand and treat disease.</p> </div> <div style="height:60px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-text-color has-dark-grey-color has-alpha-channel-opacity has-dark-grey-background-color has-background is-style-wide"/> <div style="height:60px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading has-text-align-center" id="h-decoding-the-immune-system-tobetter-diagnose-and-treat-disease">Decoding the Immune System to<br>Better Diagnose and Treat Disease</h2> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full"><img loading="lazy" decoding="async" width="125" height="125" src="https://adaptivebiotech.com/wp-content/uploads/2023/06/Two-tone-icon-Vial-q49lps8mdapoa9azbt1fdmn5hx0bhv28yoz8pl5gyq.webp" alt="" class="wp-image-26734"/></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-extra-small-font-size" id="h-blood-sample">Blood Sample</h3> <p class="has-text-align-center">The immune system is nature鈥檚 most finely tuned diagnostic, providing a fingerprint of a person鈥檚 health in their blood.</p> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-resized"><img loading="lazy" decoding="async" src="https://adaptivebiotech.com/wp-content/uploads/2023/06/icon-dna.webp" alt="" class="wp-image-26763" style="width:59px;height:125px" width="59" height="125"/></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-extra-small-font-size" id="h-immunosequencing">Immunosequencing</h3> <p class="has-text-align-center">We sequence T-cell receptors (TCRs) from each individual sample that store the diagnostic information.</p> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-resized"><img loading="lazy" decoding="async" src="https://adaptivebiotech.com/wp-content/uploads/2023/06/icon-ai.webp" alt="" class="wp-image-26762" style="width:125px;height:125px" width="125" height="125" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-ai.webp 228w, https://www.adaptivebiotech.com/wp-content/uploads/2023/06/icon-ai-150x150.webp 150w" sizes="(max-width: 125px) 100vw, 125px" /></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-extra-small-font-size" id="h-ai-machine-learning">AI/machine learning</h3> <p class="has-text-align-center">We discover disease-specific TCR signatures by comparing TCRs across disease-specific cases and controls.</p> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full"><img loading="lazy" decoding="async" width="125" height="125" src="https://adaptivebiotech.com/wp-content/uploads/2023/06/Two-tone-icon-T-Cell-Receptor-q49lps8mdapoa9azbt1fdmn5hx0bhv28yoz8pl5gyq.webp" alt="" class="wp-image-26731"/></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-extra-small-font-size" id="h-t-cell-signature">T-cell signature</h3> <p class="has-text-align-center">Disease-specific signatures may be used by doctors and researchers to improve the diagnosis and treatment of many diseases.</p> </div> </div> <div style="height:100px" aria-hidden="true" class="wp-block-spacer"></div> </div> </div> </article> </main> </div> </div> <div class="sub-footer" role="complementary"> <div class="container"> <div id="block-cta_footer" class="block block--cta fill fill--navy "> <div 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