CINXE.COM

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id="main" class="site-main"> <article id="post-26130" class="post-26130 page type-page status-publish hentry"> <div class="entry-content"> <div id="block-block_bd181ceeb2b3f37146bea01ae3d8f056" class="block block--content block--full-width align--bg-right align--bg-mobile-default size--bg-overflow size--bg-mobile-default align--vertical-text-center align--text-left align--text-mobile-center fill fill--blue vertical-padding--none text-wrap--50" style="min-height: 415px; background-repeat:no-repeat;"> <div class="bg " style="background-image: url(https://www.adaptivebiotech.com/wp-content/uploads/2023/09/banner-a-transparent.webp); min-height: 415px; background-repeat:no-repeat;"> <div class="container" style="min-height: 415px;"> <div class="acf-innerblocks-container"> <p style="margin-top:5px;margin-bottom:5px;font-size:24px"><strong>Pharma Services</strong></p> <h2 class="wp-block-heading has-white-color has-text-color" id="h-research-amp-development-applications">Research & Development<br>Applications</h2> </div> </div> </div> </div> <div class="wp-block-group alignwide is-layout-constrained wp-block-group-is-layout-constrained"> <div style="height:60px" aria-hidden="true" class="wp-block-spacer"></div> <p>Adaptive’s T-cell receptor (TCR) and B-cell receptor (BCR) sequencing assay provides a quantitative end-to-end immunosequencing solution that helps pharma partners discover the breadth and depth of the adaptive immune repertoire.</p> <div style="height:40px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading" id="h-key-applications-of-these-immune-receptor-data">Key Applications of These <br>Immune Receptor Data</h2> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-clone-tracking">Clone Tracking</h3> <p class="has-text-align-center has-medium-font-size">Track T or B cell receptors from diverse samples, pre- and post-treatment and over time.</p> <figure class="wp-block-image aligncenter size-full"><img decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-01-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp" alt="" class="wp-image-26138" title="Web-graphic–Immune-Receptor–Sequencing–01" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-01-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-01-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-repertoire-properties">Repertoire Properties</h3> <p class="has-text-align-center has-medium-font-size">Identify highly expanded clones and diversity of the repertoire.</p> <figure class="wp-block-image aligncenter size-full"><img decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-04-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp" alt="" class="wp-image-26139" title="Web-graphic–Immune-Receptor–Sequencing–04" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-04-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-04-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-public-clones">Public Clones</h3> <p class="has-text-align-center has-medium-font-size">Determine shared receptor amino acid sequences.</p> <figure class="wp-block-image aligncenter size-full"><img decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-05-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp" alt="" class="wp-image-26140" title="Web-graphic–Immune-Receptor–Sequencing–05" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-05-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-05-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> </div> </div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-immune-repertoire-overlap">Immune Repertoire Overlap</h3> <p class="has-text-align-center has-medium-font-size">Detect clonal overlap between different samples or across different time points.</p> <figure class="wp-block-image aligncenter size-full"><img loading="lazy" decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-06-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp" alt="" class="wp-image-26141" title="Web-graphic–Immune-Receptor–Sequencing–06" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-06-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-06-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-t-cell-fraction">T-cell Fraction</h3> <p class="has-text-align-center has-medium-font-size">View and monitor changes in T-cell fraction over time or between samples.</p> <figure class="wp-block-image aligncenter size-full"><img loading="lazy" decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-03-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp" alt="" class="wp-image-26142" title="Web-graphic–Immune-Receptor–Sequencing–03" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-03-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-03-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-mapping">Mapping</h3> <p class="has-text-align-center has-medium-font-size">Map enhanced sequences to <br>repertories.</p> <figure class="wp-block-image aligncenter size-full"><img loading="lazy" decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-07-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp" alt="" class="wp-image-26143" title="Web-graphic–Immune-Receptor–Sequencing–07" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-07-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-07-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> </div> </div> <div style="height:40px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide"/> <div style="height:40px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading" id="h-use-in-the-drug-discovery-and-development-process">Use in the Drug Discovery<br>and Development Process</h2> <p>We work with our partners across the research and development value chain. The rich immune receptor data that we generate provides valuable insights to inform and accelerate preclinical and clinical drug development— potentially saving significant cost and time. </p> <div style="height:40px" aria-hidden="true" class="wp-block-spacer"></div> <figure class="wp-block-image aligncenter size-large is-style-desktop"><img loading="lazy" decoding="async" width="1024" height="561" src="https://adaptivebiotech.com/wp-content/uploads/2023/01/dd-process-1024x561.png" alt="" class="wp-image-25665" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/01/dd-process-1024x561.png 1024w, https://www.adaptivebiotech.com/wp-content/uploads/2023/01/dd-process-300x164.png 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/01/dd-process-768x421.png 768w, https://www.adaptivebiotech.com/wp-content/uploads/2023/01/dd-process.png 1430w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> <figure class="wp-block-image size-full is-style-mobile"><img loading="lazy" decoding="async" width="919" height="1024" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Asset-2overview-graphic-alignment-fix-919x1024-1.webp" alt="" class="wp-image-26148" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Asset-2overview-graphic-alignment-fix-919x1024-1.webp 919w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Asset-2overview-graphic-alignment-fix-919x1024-1-269x300.webp 269w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Asset-2overview-graphic-alignment-fix-919x1024-1-768x856.webp 768w" sizes="(max-width: 919px) 100vw, 919px" /></figure> <figure class="wp-block-image size-full is-style-mobile"><img loading="lazy" decoding="async" width="964" height="1024" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Asset-4overview-graphic-alignment-fix-964x1024-1.webp" alt="" class="wp-image-26149" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Asset-4overview-graphic-alignment-fix-964x1024-1.webp 964w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Asset-4overview-graphic-alignment-fix-964x1024-1-282x300.webp 282w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Asset-4overview-graphic-alignment-fix-964x1024-1-768x816.webp 768w" sizes="(max-width: 964px) 100vw, 964px" /></figure> <div style="height:41px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide"/> <div style="height:41px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading" id="h-car-t-development-and-monitoring">CAR-T Development<br>and Monitoring</h2> <p>In March 2022, the US. Food & Drug Administration (FDA) issued draft guidance for institutions developing CAR T cell therapies. This guidance includes specific recommendations to various phases and stages of CAR T cell development—including in preclinical testing, CMC/manufacturing and monitoring of these “living medicines” for up to 15 years following infusion in patients.</p> <div id="block-block_323ab0efc0aae5a5e350b72dd565c3c8" class="block block--button align--left "> <a tabindex="" class="btn btn--green-dark" href="https://adaptivebiotech.com/wp-content/uploads/2023/03/Adaptive-white-paper11x17-ver2-web.pdf" aria-label="Download Whitepaper: " target="_blank" rel="noopener nofollow"> Download Whitepaper </a> </div> <div style="height:50px" aria-hidden="true" class="wp-block-spacer"></div> <figure class="wp-block-image aligncenter size-large is-style-desktop"><img loading="lazy" decoding="async" width="1024" height="76" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-02-1536x114-1-1024x76.webp" alt="" class="wp-image-26145" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-02-1536x114-1-1024x76.webp 1024w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-02-1536x114-1-300x22.webp 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-02-1536x114-1-768x57.webp 768w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-02-1536x114-1.webp 1536w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> <div class="wp-block-group is-layout-constrained wp-container-core-group-is-layout-1 wp-block-group-is-layout-constrained"> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-style-mobile"><img loading="lazy" decoding="async" width="939" height="201" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-03.webp" alt="" class="wp-image-26146" title="Web-graphic–Immune-Receptor–Sequencing–02" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-03.webp 939w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-03-300x64.webp 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-03-768x164.webp 768w" sizes="(max-width: 939px) 100vw, 939px" /></figure> <figure class="wp-block-image aligncenter size-full"><img loading="lazy" decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-02-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp" alt="" class="wp-image-26150" title="Web-graphic–Immune-Receptor–Sequencing–02" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-02-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-02-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-patient-s-repertoire">Patient’s Repertoire</h3> <ul class="wp-block-list"> <li>Clonality analysis of a patient’s repertoire prior to treatment with either TCR and CAR-T therapy</li> <li>Infer and confirm subject HLA prior to therapy</li> </ul> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-style-mobile"><img loading="lazy" decoding="async" width="939" height="201" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-04.webp" alt="" class="wp-image-26147" title="Web-graphic–Immune-Receptor–Sequencing–03" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-04.webp 939w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-04-300x64.webp 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-04-768x164.webp 768w" sizes="(max-width: 939px) 100vw, 939px" /></figure> <figure class="wp-block-image aligncenter size-full"><img loading="lazy" decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-03-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp" alt="" class="wp-image-26142" title="Web-graphic–Immune-Receptor–Sequencing–03" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-03-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-03-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-infusion-product">Infusion Product</h3> <ul class="wp-block-list"> <li>Clonality assessment of the product to prevent potential severe adverse events </li> <li>Monitor infusion product throughout the manufacturing process</li> </ul> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image aligncenter size-full is-style-mobile"><img loading="lazy" decoding="async" width="939" height="200" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-05.webp" alt="" class="wp-image-26144" title="Web-graphic–Immune-Receptor–Sequencing–04" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-05.webp 939w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-05-300x64.webp 300w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-CART-Development-and-Monitoring-05-768x164.webp 768w" sizes="(max-width: 939px) 100vw, 939px" /></figure> <figure class="wp-block-image aligncenter size-full"><img loading="lazy" decoding="async" width="185" height="185" src="https://adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-04-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-1.webp" alt="" class="wp-image-26152" title="Web-graphic–Immune-Receptor–Sequencing–04" srcset="https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-04-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-1.webp 185w, https://www.adaptivebiotech.com/wp-content/uploads/2023/05/Web-graphic-Immune-Receptor-Sequencing-04-q49lps8n3lz6z3sndicnj0g5w0grxdsyxofn6niu0q-1-150x150.webp 150w" sizes="(max-width: 185px) 100vw, 185px" /></figure> <h3 class="wp-block-heading has-text-align-center has-blue-color has-text-color has-small-font-size" id="h-monitoring">Monitoring</h3> <ul class="wp-block-list"> <li>Monitor expansion and persistence of product in blood vs. site of disease</li> <li>Determine biomarkers of response (e.g., magnitude and durability)</li> </ul> </div> </div> </div> <div style="height:100px" aria-hidden="true" class="wp-block-spacer"></div> </div> </div> </article> </main> </div> </div> <div class="sub-footer" role="complementary"> <div class="container"> <div id="block-cta_footer" class="block block--cta fill fill--navy "> <div 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