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expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); 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digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. 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alt='WB31379-289x266-MD_NP' title='WB31379-289x266-MD_NP'></picture></div><style> #cq-textimage-jsp-46313194-430f-4284-a344-29947264394dSnippetParsystextimage_cc40 { max-width: 100%; } #cq-textimage-jsp-46313194-430f-4284-a344-29947264394dSnippetParsystextimage_cc40 img { width: 100%; max-width: 266px; } </style><script type="text/javascript"> $( document ).ready(function() { if(!!window.picturefill){ window.picturefill(); } }); </script></a></div><div class="seo-event-text" data-seo-schema='' data-seo-element='description'></div><div class="clearfix"></div></div></div></div></div></div></div></div><div class="mondrian-module-inner mondrian-module-list"><div class="par2 parsys"></div></div></div></div></div></div><div class="reference parbase section"><div class="cq-dd-paragraph"><div class="ltrawhtml_4fb9 LTRawHTML"><style> .ux-tool-label { display: none; border-left: 50px #dcdcdc solid; padding-left: 10px; font-style: italic; font-size: 14px; } .cq-wcm-edit .ux-tool-label { display: block; } </style><div class="ux-tool-label ">Interact Reference Component</div><style> .mondrian-module-list { background-color:transparent!important; height: 100%; overflow-x: hidden; overflow-y: hidden; position: absolute; right: 0; top: 0; } .mondrian-module-list UL,.mondrian-module-list UL.default,.mondrian-module-list UL.mondrian-featured-list { background-color:transparent!important; } .mondrian-module-list UL LI,.mondrian-module-list UL.default LI,.mondrian-module-list UL.mondrian-featured-list LI { background-color:#5D89B3; } </style><script> $(".mondrian-module-outer > .mondrian-module-list").remove(); $(".mondrian-module-d").removeClass("mondrian-module-d").addClass("mondrian-module-f"); $(".mondrian-submodule-right").removeClass(".mondrian-submodule-right").addClass("mondrian-module-list"); </script></div></div></div><div class="textimage parbase textimage-left section"><div class="text"><p>RNAi is a specific, potent, and highly successful approach for loss-of-function studies in virtually all eukaryotic organisms. At Thermo Fisher Scientific, we have developed two types of small RNA molecules that function in RNAi: short interfering RNA (siRNA) molecules and microRNAs (miRNA). Thermo Fisher Scientific offers Invitrogen products for RNAi analysis <i>in vitro </i>and <i>in vivo</i>, including libraries for high-throughput applications. Your choice of tool depends on your model system, the length of time you require knockdown, and other experimental parameters.</p><p><a class="btn btn-primary" href="/sg/en/home/global/forms/screening-solutions-guide-download.html">Download screening solutions resource guide</a></p></div><div class="clearfix"></div></div><div class="divider section"><hr /></div><div class="well-cmp section"><div class="well well-blue-light well-default"><div class="well-container" style=""><div class="well-content"><div class="parsys"><div class="textimage parbase section"><div class="image" id="cq-textimage-jsp-1b88552a-a21a-4044-a72b-27f4fa6aa7a3MainParsyswell_e4f4uipartextimage_95ab"><div class="image-container"><picture><source srcset='https://www.thermofisher.com/sg/en/home/life-science/rnai/jcr:content/MainParsys/well_e4f4/uipar/textimage_95ab/image.img.full.high.png/1627522390765.png' media="(min-width: 1px)"><img 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alt='RNAi-product-0729' title='RNAi-product-0729'></picture></div><style> #cq-textimage-jsp-1b88552a-a21a-4044-a72b-27f4fa6aa7a3MainParsyswell_e4f4uipartextimage_95ab { max-width: 100%; } #cq-textimage-jsp-1b88552a-a21a-4044-a72b-27f4fa6aa7a3MainParsyswell_e4f4uipartextimage_95ab img { width: 100%; max-width: 250px; } </style><script type="text/javascript"> $( document ).ready(function() { if(!!window.picturefill){ window.picturefill(); } }); </script></div><div class="seo-event-text" data-seo-schema='' data-seo-element='description'><div class="text"><h4 style="color: #ee3134;">Save more on your RNA delivery tools!</h4><p>Purchase any RNAi products with the Lipofectamine RNAiMAX and save <b style="color: #ee3134;">20%</b> on your entire order before Sep 30, 2021!</p><p><a class="cta-link btn btn-primary" href="/sg/en/home/products-and-services/promotions/RNAi-promo-sg.html?CID=fl-RNAipromo">Learn More </a></p></div></div><div class="clearfix"></div></div></div></div></div></div></div><div class="divider section"><hr /></div><div comp-order="bycol" class="parsys_column cq-colctrl-lt0"><div class="parsys_column cq-colctrl-lt0-c0"><div container-id="cq-colctrl-lt0" comp-id="A1"><div class="text parbase section"><ul><li><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/ambion-silencer-select-sirnas.html">Silencer Select siRNAs</a></li><li><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/ambion-silencer-select-sirnas/make-your-silencing-roar.html">Silencer Select siRNAs for Long Non-Coding RNAs</a></li><li><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/ambion-silencer-select-sirnas.html">Silencer Select pre-designed and validated siRNAs</a></li><li><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/silencer-pre-designed-validated-sirnas.html">Silencer siRNAs</a></li><li><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/stealth-rnai-technology.html">Stealth siRNAs</a></li><li><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/stealth-rnai-technology.html">Stealth pre-designed siRNAs</a></li><li><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/sirna-libraries.html">siRNA libraries</a></li></ul></div></div></div><div class="parsys_column cq-colctrl-lt0-c1"><div container-id="cq-colctrl-lt0" comp-id="B1"><div class="text parbase section"><ul><li><a href="/sg/en/home/life-science/epigenetics-noncoding-rna-research/mirna-analysis/mirna-mimics-inhibitors.html">mirVana Mimics & Inhibitors</a></li><li><a href="/sg/en/home/life-science/epigenetics-noncoding-rna-research/mirna-analysis/mirna-mimics-inhibitors.html">Ambion Pre-miR miRNA Precursors</a></li><li><a href="/sg/en/home/life-science/epigenetics-noncoding-rna-research/mirna-analysis/mirna-mimics-inhibitors.html">Ambion Anti-miR miRNA Inhibitors</a></li><li><a href="/sg/en/home/life-science/epigenetics-noncoding-rna-research/mirna-analysis/mirna-mimics-inhibitors/mirna-libraries.html">miRNA libraries</a></li></ul></div></div></div></div><div style="clear:both"></div><div class="divider section"><hr /></div><div class="heading section"><h2> Featured RNAi categories </h2></div><div comp-order="bycol" class="parsys_column cq-colctrl-lt0"><div class="parsys_column cq-colctrl-lt0-c0"><div container-id="cq-colctrl-lt0" comp-id="A1"><div class="heading section"><h3><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis.html">siRNA</a></h3></div></div><div container-id="cq-colctrl-lt0" comp-id="A2"><div class="text parbase section"><p>Effectively knock down gene expression using our proprietary Silencer Select, Stealth RNAi, and Silencer siRNAs<br></p></div></div></div><div class="parsys_column cq-colctrl-lt0-c1"><div container-id="cq-colctrl-lt0" comp-id="B1"><div class="heading section"><h3><a href="/sg/en/home/life-science/epigenetics-noncoding-rna-research/mirna-analysis/mirna-mimics-inhibitors.html">miRNA</a></h3></div></div><div container-id="cq-colctrl-lt0" comp-id="B2"><div class="text parbase section"><p>Analyze miRNA function with Invitrogen <i>mir</i>Vana miRNA mimics and inhibitors</p></div></div></div></div><div style="clear:both"></div><div comp-order="bycol" class="parsys_column cq-colctrl-lt0"><div class="parsys_column cq-colctrl-lt0-c0"><div container-id="cq-colctrl-lt0" comp-id="A1"><div class="heading section"><h3><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/controls-for-rnai-experiments.html">RNAi controls</a></h3></div></div><div container-id="cq-colctrl-lt0" comp-id="A2"><div class="text parbase section"><p>Find a complete solution for successful <i>in vivo </i>RNAi experiments including the highest nuclease stability Invitrogen Ambion <i>In Vivo </i>siRNA<br></p></div></div></div><div class="parsys_column cq-colctrl-lt0-c1"><div container-id="cq-colctrl-lt0" comp-id="B1"><div class="heading section"><h3><a href="/sg/en/home/references/gibco-cell-culture-basics/transfection-basics/guidelines-for-rna-transfection/optimizing-sirna-transfection.html">RNAi Transfection</a></h3></div></div><div container-id="cq-colctrl-lt0" comp-id="B2"><div class="text parbase section"><p>Determine the best approach for delivering RNAi to your cells using either lipid-mediated transfection (Invitrogen Lipofectamine reagents) or the Invitrogen Neon Transfection System</p></div></div></div></div><div style="clear:both"></div><div comp-order="bycol" class="parsys_column cq-colctrl-lt0"><div class="parsys_column cq-colctrl-lt0-c0"><div container-id="cq-colctrl-lt0" comp-id="A1"><div class="heading section"><h3><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/sirna-libraries.html">siRNA libraries</a></h3></div></div><div container-id="cq-colctrl-lt0" comp-id="A2"><div class="text parbase section"><p>Increase discovery with the widest selection of predefined and custom RNAi libraries available<br></p></div></div></div><div class="parsys_column cq-colctrl-lt0-c1"><div container-id="cq-colctrl-lt0" comp-id="B1"><div class="heading section"><h3><a href="/sg/en/home/life-science/rnai/introduction-to-in-vivo-rnai.html"><em>In Vivo</em> siRNA</a></h3></div></div><div container-id="cq-colctrl-lt0" comp-id="B2"><div class="text parbase section"><p>Find a complete solution for successful<i> in vivo</i> RNAi experiments including the highest nuclease stability Ambion <i>In Vivo</i> siRNA</p></div></div></div></div><div style="clear:both"></div><div comp-order="bycol" class="parsys_column cq-colctrl-lt0"><div class="parsys_column cq-colctrl-lt0-c0"><div container-id="cq-colctrl-lt0" comp-id="A1"><div class="heading section"><h3><a href="/sg/en/home/life-science/rnai/vector-based-rnai.html">Vector-Based RNAi </a></h3></div></div><div container-id="cq-colctrl-lt0" comp-id="A2"><div class="text parbase section"><p>Reagents & kits to achieve transient or stable target knockdown in hard-to-transfect cells including Invitrogen BLOCK-iT system products</p></div></div></div><div class="parsys_column cq-colctrl-lt0-c1"></div></div><div style="clear:both"></div><div class="well-cmp section"><div class="well "><div class="well-container" style=""><div class="well-content"><div class="parsys"><div comp-order="bycol" class="parsys_column cq-colctrl-lt0"><div class="parsys_column cq-colctrl-lt0-c0"><div container-id="cq-colctrl-lt0" comp-id="A1"><div class="text parbase section"><h3><a href="https://www.nature.com/articles/nature12748" target="_blank">Silencer Select siRNA for a genome-wide screen resulted in new Parkinson’s disease targets</a></h3><p>This Nature publication from NCATS, NIH demonstrates the utility of Silencer Select Genome-Wide siRNA library for arrayed high throughput screening in effectively identifying novel drug targets for Parkinson’s disease. The workflow adopted for this effort also was dependent on other products such as Lipofectamine RNAiMAX and Gibco Media for its success. Final validation of lead drug targets was accomplished by creating knockout cell lines using the TAL-effector endonuclease (TALEN) technology.</p></div></div></div><div class="parsys_column cq-colctrl-lt0-c1"><div container-id="cq-colctrl-lt0" comp-id="B1"><div class="heading section"><h2> Education </h2></div></div><div container-id="cq-colctrl-lt0" comp-id="B2"><div class="text parbase section"><p><a class="cta-link" href="/sg/en/home/life-science/cloning/synthetic-biology/synthetic-biology-webinars/rnai-screening-webinar-q-a.html" target="_blank">FAQs from the webinar</a></p></div></div><div container-id="cq-colctrl-lt0" comp-id="B3"><div class="text parbase section"><ul class="document-list"><li><a href="/sg/en/home/products-and-services/promotions/rnai-genome-modulation-handbook.html">Request RNAi Handbook</a></li><li><a class="icon pdf icon" href="/content/dam/LifeTech/migration/files/rnai-epigenetics-gene-regulation/pdfs.par.18251.file.dat/CO04539_miRNA%200213_FHR%20.pdf">mirVana miRNA mimics and inhibitors flyer</a></li><li><a class="icon pdf icon" href="/content/dam/LifeTech/migration/files/rnai-epigenetics-gene-regulation/pdfs.par.18251.file.dat/CO04541_siRNA%200213_FHR.pdf">Ambion siRNA flyer</a></li></ul></div></div><div container-id="cq-colctrl-lt0" comp-id="B4"><div class="heading section"><h3> Questions? </h3></div></div><div container-id="cq-colctrl-lt0" comp-id="B5"><div class="text parbase section"><p>If you have any questions on products or ordering, please contact us at <a href="mailto:RNAisupport@thermofisher.com?subject=RNAi%20Research">RNAisupport@thermofisher.com</a></p></div></div></div></div><div style="clear:both"></div></div></div></div></div></div><div class="reference parbase section"><div class="cq-dd-paragraph"><div class="well-cmp"><div class="well well-blue-light well-default"><div class="well-container" style=""><div class="well-content"><div class="parsys"><div class="heading section"><h3> Shop for everyday lab essentials to power your transfection steps </h3></div><div comp-order="bycol" class="parsys_column cq-colctrl-lt2"><div class="parsys_column cq-colctrl-lt2-c0"><div container-id="cq-colctrl-lt2" comp-id="A1"><div class="image parbase section"><div id="cq-image-jsp-f8a63516-a6b6-48c0-af9b-fbf2109ee5d1MainParsyswell_ad6uiparimage_4060"><picture><source srcset='https://www.thermofisher.com/sg/en/reference-components/bid-reference-components/pca-reference-components/jcr:content/MainParsys/well_ad6/uipar/image_4060/foregroundimg.img.320.low.jpg/1729526171660.jpg' media="(min-width: 1px)"><source srcset='https://www.thermofisher.com/sg/en/reference-components/bid-reference-components/pca-reference-components/jcr:content/MainParsys/well_ad6/uipar/image_4060/foregroundimg.img.320.medium.jpg/1729526171660.jpg' media="(min-width: 320px)"><source 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</script></div></div></div></div><div class="parsys_column cq-colctrl-lt2-c1"><div container-id="cq-colctrl-lt2" comp-id="B1"><div class="text parbase section"><p>We've made it easier for you to quickly find and buy products for every step in your transfection workflow.</p><p><a class="cta-link" href="/sg/en/home/products-and-services/promotions/life-science/everyday-essentials/transfection.html">Shop now</a></p></div></div></div></div><div style="clear:both"></div></div></div></div></div></div></div></div></div><div><div class="MainInheritParsys iparsys parsys"><div class="reference parbase section"><div class="cq-dd-paragraph"><div class="well-cmp"><div class="well well-gray-lighter well-default"><div class="well-container" style=""><div class="well-content"><div class="parsys"><div comp-order="bycol" class="parsys_column cq-colctrl-lt0"><div class="parsys_column cq-colctrl-lt0-c0"><div container-id="cq-colctrl-lt0" comp-id="A1"><div class="heading section"><div class="h2"> Resources </div></div></div><div container-id="cq-colctrl-lt0" comp-id="A2"><div class="text parbase section"><ul class="the-icons clearfix"><li><a href="/sg/en/home/technical-resources/technical-reference-library/rnai-support-center.html">RNAi Support Center</a></li><li><a href="/sg/en/home/products-and-services/promotions/rnai-genome-modulation-handbook.html">RNAi Handbook</a></li><li><a href="/sg/en/home/references/gibco-cell-culture-basics/transfection-basics/guidelines-for-rna-transfection/optimizing-sirna-transfection.html">Optimizing siRNA Transfection</a></li><li><a href="/sg/en/home/life-science/rnai/synthetic-rnai-analysis/controls-for-rnai-experiments.html">Controls for RNAi Experiments</a></li></ul></div></div></div><div class="parsys_column cq-colctrl-lt0-c1"><div container-id="cq-colctrl-lt0" comp-id="B1"><div class="heading section"><div class="h2"> Questions? </div></div></div><div container-id="cq-colctrl-lt0" comp-id="B2"><div class="text parbase section"><p><b>Technical 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