“Moving forward, cancer may not be a death threat but a manageable disease with strong control”

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href="/category/bio-tech">BioTech</a></li> <li><a href="/category/therapeutics">Therapeutics</a></li> <li class="active">“Moving forward, cancer may not be a death threat but a manageable disease with strong control”<span></span></li> </ol> </div> <div class="col-md-12 gray"> <h3 class="blue">“Moving forward, cancer may not be a death threat but a manageable disease with strong control”</h3> <p class="g1"> 31 October 2024 | Opinion | By Ayesha Siddiqui</p> <ul class="share-social pull-right"> <li><a href="https://twitter.com/share" title="Twitter" class="twitter-share-button" data-text="“Moving forward, cancer may not be a death threat but a manageable disease with strong control”" data-url="" data-via="AsiaBioSpectrum" data-related="twitterapi,twitter" data-size="default"></a></li> <li><span class="fb-share-button" data-href="https://www.biospectrumasia.com/opinion/98/25131/moving-forward-cancer-may-not-be-a-death-threat-but-a-manageable-disease-with-strong-control.html" data-layout="button_count" data-type="button"></span></li> <li><div class="g-plus" data-href="https://www.biospectrumasia.com/opinion/98/25131/moving-forward-cancer-may-not-be-a-death-threat-but-a-manageable-disease-with-strong-control.html" data-action="share"></div></li> <li><script type="IN/Share" data-counter="right" data-url="https://www.biospectrumasia.com/opinion/98/25131/moving-forward-cancer-may-not-be-a-death-threat-but-a-manageable-disease-with-strong-control.html"></script></li> <li><a onclick="window.location='mailto:?subject=%E2%80%9CMoving%20forward%2C%20cancer%20may%20not%20be%20a%20death%20threat%20but%20a%20manageable%20disease%20with%20strong%20control%E2%80%9D%20on%20BioSpectrum Asia&body=From%20BioSpectrum Asia...%0D%0A%0D%0A“Moving forward, cancer may not be a death threat but a manageable disease with strong control”%0D%0A%0D%0Ahttps://www.biospectrumasia.com/opinion/98/25131/moving-forward-cancer-may-not-be-a-death-threat-but-a-manageable-disease-with-strong-control.html'" title="mail"><i class="fa fa-envelope" style="color:#ee1d25;cursor: pointer;"></i></a></li> <li><a href="/article/pdf/25131" title="Download PDF"><i class="fa fa-download" style="color:#ff7800;"></i></a></li> <li><a href="#" title="Play" id="play-button"><i class="fa fa-play" style="color:#26C281;"></i></a></li> <li style="display: none;"><a href="#" title="Resume" id="resume-button"><i class="fa fa-play" style="color:#26C281;"></i></a></li> <li style="display: none;"><a href="#" title="Pause" id="pause-button"><i class="fa fa-pause" style="color:#3598dc;"></i></a></li> <li style="display: none;"><a href="#" title="Stop" id="stop-button"><i class="fa fa-stop" style="color:#D91E18;"></i></a></li> </ul> </div> <div class="clearfix"></div> <div class="col-md-12 pt text"> <p class="bold"> Cartherics Pty Ltd, a Melbourne-based biotechnology company led by renowned stem cell biologist and IVF pioneer Prof Alan Trounson, is developing cell-based immunotherapies for cancer treatment, focusing on a portfolio of CAR-T and CAR-NK cell products. The company’s allogeneic (off-the-shelf) cell platform utilises induced pluripotent stem cells (iPSCs) generated from donated cord blood, which can be differentiated into NK cells, T cells, and other immune system cells. Cartherics' lead product, CTH-401, is an investigational allogeneic iPSC-derived chimeric antigen receptor (CAR) natural killer (NK) cell therapy designed to target solid tumours. Following a successful pre-investigational new drug (pre-IND) meeting with the US Food and Drug Administration (FDA), CTH-401 is set to enter clinical trials for ovarian cancer in 2025. Subject to early clinical data, CTH-401 will subsequently enter a basket trial targeting other TAG-72+ solid cancers. Prof. Alan Trounson, CEO of Cartherics, sheds light on iPSCs for CAR-T therapies, the future of immunotherapies, and the CGT landscape in the APAC region. </p> <div class="row"> <div class="col-md-12 col-centered"> <img src="/uploads/articles/038_alan_trounson_20220920_2_-25131.jpg" class="thumbnail" alt="" /> <p></p> </div> </div> <div id="page1"> <p style="text-align: justify;"><strong>Could you explain more about the advantages of using iPSCs from cord blood for creating your ‘off-the-shelf’ CAR-NK and CAR-T therapies?</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">Umbilical cord blood contains pristine blood cells that have very few spontaneous or induced mutations, can be selected for homozygosity at the HLA locus, that provide the opportunity for transplant compatibility and can be turned into iPSCs that are immortal and can be directed into any cell of the body. These iPSCs can be easily gene-edited and have exact editing and freedom from genetic changes by clonal derivation as a therapeutic product free of potential oncogenic inducers. The cells produced are exact clones of each other, much like a drug product. This can only be achieved with pluripotent stem cells. Directing the gene-edited iPSCs into CAR-T and CAR-NK products involves a proprietary method as is the manufacturing process. Consequently, we can use CAR-NK cells for allogeneic (off-the-shelf) therapy. CAR-T cells produced this way need further alteration for allogeneic therapy.</span></p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"><strong>Your lead product, CTH-401, targets TAG-72, a well-validated tumour marker. What makes TAG-72 a particularly compelling target for CAR-NK therapy, and how does CTH-401 differentiate itself from other therapies targeting similar markers? </strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">TAG-72 is a pan-adenocarcinoma marker expressed highly on the cell surface by cancers of the internal organs. It is not expressed elsewhere in the adult body except for the secretary uterine endometrium. It is expressed in embryonic tissues during rapid expansion. TAG-72 is found in more than 90 per cent of ovarian cancers and on most other adenocarcinomas (pancreatic, gastric, liver, kidney etc. cancers). CTH-401 is the only natural killer (NK) cell product currently under development that incorporates a CAR that targets TAG-72. It is clonally derived and DNA deep sequenced to ensure safety from secondary cancers and other undesirable mutations. In addition, we have knocked out two genes responsible for inhibiting immune cell killing in solid tumours. This unique combination of features enhances the therapeutic potential of CTH-401, providing a more effective and targeted treatment option for patients with solid tumours.</span></p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"><strong>Are there any strategic partnerships or collaborations that have been crucial to Cartherics' advancements? How do you see these partnerships evolving as the company grows?</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">We work closely with partner universities and medical research institutes in federal and state grants focused on developing the company’s products. There are also partnerships established with other companies such as ToolGen Inc. in Korea who have provided rights to gene editing and gene knockout technologies. We have provided rights to some of our products to Shunxi Holdings in greater China. Both Shunxi and ToolGen own equity in Cartherics.</span></p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"><strong>Beyond CTH-401, what other products or therapies are in your pipeline that you are most excited about, and what therapeutic areas are they focused on? </strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">Many opportunities can evolve off the Cartherics platform technology, including many new cancer targets that include triple-negative breast cancer, brain cancer (glioblastoma), pancreatic, prostate and gastric cancers. We are also exploring other diseases such as endometriosis. Further opportunities exist in other conditions such as autoimmunity, fibrosis and neurological conditions. We will remain focused on cancer applications as a priority but opportunities for entry into these other conditions are being explored in collaboration with other institutions.</span></p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"><strong>With the growing global demand for immunotherapies, do you have plans to expand beyond Australia, particularly into markets like the US, Europe, or Asia?</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">We’re open to expanding beyond Australia and already have a partnership in greater China. Logically, Cartherics will develop collaborations and partnerships in the US and Europe but is focused on developing and testing our initial products in Australia under FDA licensing. </span><em><span style="font-weight: 400;"><br /><br /></span></em></p> <p style="text-align: justify;"><strong>In five years, where do you see Cartherics and the field of cell-based cancer immunotherapies? What breakthroughs do you hope to achieve? </strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">Immunotherapies will be established as a way to manage cancer and may be a composite of antibodies, and molecular control of immune function (e.g. checkpoint inhibitors, cell therapies, RNA technologies and immunisation). It is possible that cancer may not be a death threat but a manageable disease with strong control. This is likely to take a decade or more but in five years this could well be recognised in medicine. Other applications are almost certain to follow in the areas mentioned above. We expect Cartherics to take a leadership position in these advances in medicine.</span></p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"><strong>How do you see the current trends in CGT shaping the future of cancer immunotherapies, and where exactly does Cartherics fit? </strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">The ability to design cell and gene therapies using pluripotent stem cells and accurate gene editing tools such as CRISPR Cas9 has revolutionised cell and gene therapy. The potential is incredible and will be determined by adaptation and innovation in the research sector. We have a strong research base and deep collaborations in the academic and medical research sectors. We would expect to bring new and novel therapies continuously through the pipeline into clinical development and therapeutic application. We expect to remain in Australia to take advantage of the strong research and government support available to outcome-driven biotechnology.</span></p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"><strong>Ayesha Siddiqui</strong></p> </div> <ins class="aso-zone" data-zone="84574"></ins><script data-cfasync="false" async="async" type="text/javascript" src="https://media.aso1.net/js/code.min.js"></script>  <div class="row"> <div class="col-md-12 gray"> <h4>Sign up for the editor pick and get articles like this delivered right to your inbox.</h4> <form method="post" role="form" name="editorPickForm" action="/article-editors-pick-data" class="form-horizontal"> <div class="col-md-5"> <img src="/cms-images/editor-picks-E-mailer.jpg" class="img-responsive" alt="Editors Pick" /> </div> <div class="col-md-7"> <div class="form-group"> <label class="control-label" for="ename">Name<span class="required"> * </span></label> <input type="text" name="editorPickForm[name]" class=" form-control" id="ename" required> </div> <div class="form-group"> <label class="control-label" for="eemail">Email<span class="required"> * </span></label> <input type="email" name="editorPickForm[email]" class=" form-control" id="eemail" required> </div> <div class="form-group"> <label class="control-label" for="ecountry">Country<span class="required"> * </span></label> <input type="text" name="editorPickForm[country]" class=" form-control" id="ecountry" required> </div> <div class="form-group"> <label class="control-label" for="eorganisation">Organisation<span class="required"> * </span></label> <input type="text" name="editorPickForm[organisation]" class=" form-control" id="eorganisation" required> </div> <div class="form-group"> <label class="control-label" for="ecountry-code">Contact Number<span class="required"> * </span></label> <input type="text" name="editorPickForm[contact]" class=" form-control col-md-2" id="econtact" required> <span class="help-block">+Country Code-Phone Number(xxx-xxxxxxx)</span> </div> <button type="submit" class="btn btn-success">Submit</button> </div> </form><br/> </div> </div><br/>  <div class="row"> <div class="col-md-12 gray"> <h3>Comments</h3> <form role="form" name="commentForm" id="commentForm0" ng-controller="SiteCommentController" ng-submit="submitComment()" ng-model="commentAction" ng-init="commentAction='/comment-handle/'"> <div class="alert alert-success alert-dismissable" id="comment-success-box-0" style="display: none;"> <a href="#" class="close" data-dismiss="alert" aria-label="close">×</a> <h3>Thank You</h3> <strong>Your comment has been submitted for approval.</strong><br/> Please note that comments are moderated and are generally published if they are on-topic and not abusive. </div> <div class="form-group"> <label class="sr-only" for="comment-message_0">Comment</label> <textarea name="comment" placeholder="Enter your comment here" class="contact-message form-control" id="comment-message_0" ng-model="commentFormData.comment"></textarea> </div> <div class="alert alert-danger alert-dismissable ng-cloak" ng-if="sessionError != '0'"> <a href="#" class="close" data-dismiss="alert" aria-label="close">×</a> Your session has been expired. 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<div class="form-group"> <label><input type="checkbox" value="1" required> I accept the <a href="/pdf/terms-and-conditions.pdf" target="_blank">terms & condition</a> & <a href="/pdf/privacy-policy.pdf" target="_blank">Privacy policy</a></label> </div> <div class="row"> <div class="col-md-12"> <div class="form-group"> <button class="btn btn-danger col-md-12" type="submit">SUBSCRIBE!</button> </div> </div> </div> </form> </div> <div class="modal-footer"> <button type="button" class="btn btn-default" data-dismiss="modal">Close</button> </div> </div> </div> </div>     <script src="/bundles/interlinksapp/app/app-asia/js/jquery.min.js" type="text/javascript"></script> <script src="/bundles/interlinksapp/app/app-asia/js/bootstrap.min.js" type="text/javascript"></script>   <script src="/bundles/interlinksapp/app/app-asia/js/dips-site-common.js" type="text/javascript"></script> <script type="text/javascript"> var passwrodLength = "8"; $(document).ready(function() { $('#email').on('keyup', function(event) { this.value = this.value.toLowerCase(); $('#enquiry-email-error').hide(); }); $('#save-enquiry-btn').on('click', function(event) { saveEnquiry(this); }); $('#enquiryForm').on('keyup', '#name, #email, #contact, #message', function(event) { $('#enquiry-error').hide(); }); $("#contact").on('keydown', function (e) { allNumeric(e); }); $('#account-email').on('blur', function(event) { isEmailExist(); }); $('#account-email').on('keyup', function(event) { this.value = this.value.toLowerCase(); $('#account-email-error').hide(); }); $('#loginForm').on('keydown', '#login-email, #login-password', function(event) { $('#login-email-error').hide(); $('#login-password-error').hide(); }); $("#registrationForm").on('keydown', '#account-confirm-password, #account-password, #account-firstName, #account-lastName', function (e) { $('#account-password-error').hide(); $('#account-pass-error').hide(); $('#account-firstName-error').hide(); $('#account-lastName-error').hide(); }); $('#forgotPasswordForm').on('keydown', '#forgot-pass-email', function(event) { $('#forgot-pass-email-error').hide(); }); }); function validatePassword() { var password = $("#account-password").val(); var confirmPassword = $("#account-confirm-password").val(); if(password == '') { $('#account-pass-error').text("Password should not be empty.").show(); return false; } else { if(password.length < passwrodLength) { $('#account-pass-error').text("Your password must be at least " + passwrodLength + " characters long.").show(); return false; } } if(confirmPassword == '') { $('#account-password-error').text("Confirm Password should not be empty.").show(); return false; } else { if(confirmPassword.length < passwrodLength) { $('#account-password-error').text("Your password must be at least " + passwrodLength + " characters long.").show(); return false; } } if (password != confirmPassword) { $('#account-password-error').text("'Password' and 'Confirm Password' must match.").show(); return false; } return true; } function validateRegistration() { var nameRegex = /^[a-zA-Z]+$/; if($("#account-firstName").val() == '') { $('#account-firstName-error').text("First name should not be empty.").show(); return false; } else { if (!$("#account-firstName").val().match(nameRegex)) { $('#account-firstName-error').text("Please enter a valid first name.").show(); return false; } } if($("#account-lastName").val() == '') { $('#account-lastName-error').text("Last name should not be empty.").show(); return false; } else { if (!$("#account-lastName").val().match(nameRegex)) { $('#account-lastName-error').text("Please enter a valid last name.").show(); return false; } } if($("#account-email").val() == '') { $('#account-email-error').text("Email address should not be empty.").show(); return false; } else { if(!validateEmail($("#account-email").val())) { $('#account-email-error').text("Please enter a valid email address.").show(); return false; } //isEmailExist(); var emailStatus = $('#is-email-exist').val(); if(emailStatus == '1') { $('#account-email-error').text('That username is taken. Try another one.').show(); return false; } } return validatePassword(); } function validateLogin() { if($("#login-email").val() == '') { $('#login-email-error').text("Email address should not be empty.").show(); return false; } else { if(!validateEmail($("#login-email").val())) { $('#login-email-error').text("Please enter a valid email address.").show(); return false; } } if($("#login-password").val() == '') { $('#login-password-error').text("Password should not be empty.").show(); return false; } else { if($("#login-password").val().length < passwrodLength) { $('#login-password-error').text("Your password must be at least " + passwrodLength + " characters long.").show(); return false; } } return true; } function validateForgotPassword() { if($("#forgot-pass-email").val() == '') { $('#forgot-pass-email-error').text("Email address should not be empty.").show(); return false; } else { if(!validateEmail($("#forgot-pass-email").val())) { $('#forgot-pass-email-error').text("Please enter a valid email address.").show(); return false; } } return true; } function isEmailExist() { var email = $('#account-email').val(); $('#is-email-exist').val(0); $.post("/email-validator/", {'email':email}, function(data) { if(data.response.isEmailExist == true) { $('#is-email-exist').val(1); $('#account-email-error').text('That username is taken. Try another one.').show(); } },'json'); } function validateNewsletter() { if($("#nl-email").val() == '') { $('#nl-email-error').text("Email address should not be empty.").show(); return false; } else { if(!validateEmail($("#nl-email").val())) { $('#nl-email-error').text("Please enter a valid email address.").show(); return false; } } return true; } </script> <script src="/bundles/interlinksapp/assets/global/plugins/angularjs/angular.min.js" type="text/javascript"></script> <script src="/bundles/interlinksapp/assets/global/plugins/angularjs/angular-route.min.js" type="text/javascript"></script> <script src="/bundles/interlinksapp/app/app-asia/js/SitePollController.js?20241127082952849719" type="text/javascript"></script> <script> (function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_GB/sdk.js#xfbml=1&version=v2.9&appId=220402091798716"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); </script> <script src="//platform.twitter.com/widgets.js"></script> <script src="https://apis.google.com/js/platform.js" async defer></script> <script src="//platform.linkedin.com/in.js" type="text/javascript"> lang: en_US</script> <script src="/bundles/interlinksapp/app/app-asia/js/SiteCommentController.js?20241127082952849728" type="text/javascript"></script> <script src="/bundles/interlinksapp/assets/global/plugins/text-to-speech/articulate.min.js" type="text/javascript"></script> <script type="text/javascript"> $(function() { //This code for article page toggle view comment box $('.toggle').click(function(event) { $('#credits').toggleClass('hidden show'); }); $('.clogin-button').click(function(event) { $('#myModal').modal('show'); $('#login-tab').trigger('click'); }); $('.cregister-button').click(function(event) { $('#myModal').modal('show'); $('#registration').trigger('click'); }); //Text to speech script Start var selector = $('#page1'); $('#play-button').click(function(event) { // Sets the pitch of the speaking voice; // default = 1.0; range = [0 - 2] selector.articulate('pitch', 2); // Sets the rate of the speaking voice // default = 1.1; range = [0.1 - 10] selector.articulate('rate', 0.8); selector.articulate('speak'); $('#play-button').parent().hide(); $('#resume-button').parent().hide(); $('#pause-button').parent().show(); $('#stop-button').parent().show(); }); $('#pause-button').click(function(event) { selector.articulate('pause'); $('#resume-button').parent().show(); $('#pause-button').parent().hide(); }); $('#stop-button').click(function(event) { selector.articulate('stop'); $('#play-button').parent().show(); $('#resume-button').parent().hide(); $('#pause-button').parent().hide(); }); $('#resume-button').click(function(event) { // Sets the pitch of the speaking voice; // default = 1.0; range = [0 - 2] selector.articulate('pitch', 2); // Sets the rate of the speaking voice // default = 1.1; range = [0.1 - 10] selector.articulate('rate', 0.8); selector.articulate('resume'); $('#resume-button').parent().hide(); $('#pause-button').parent().show(); }); //Text to speech script End }); </script> <script> function speak(obj) { $(obj).articulate('speak'); //$(obj).articulate('rate', 0.5); }; function pause() { $().articulate('pause'); }; function resume() { $().articulate('resume'); }; function stop() { $().articulate('stop'); }; </script>  <script> (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','https://www.google-analytics.com/analytics.js','ga'); ga('create', 'UA-58743002-1', 'auto'); ga('send', 'pageview'); </script>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-CWX6K6L4H3"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-CWX6K6L4H3'); </script>  <script src="https://www.google.com/recaptcha/api.js" async defer></script> <script> var recaptcha_response = ''; function submitUserForm() { if(recaptcha_response.length == 0) { document.getElementById('g-recaptcha-error').innerHTML = '<span style="color:red;">This field is required.</span>'; return false; } return true; } function verifyCaptcha(token) { recaptcha_response = token; document.getElementById('g-recaptcha-error').innerHTML = ''; } </script>  </body> </html>

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