CINXE.COM

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class="banner-sub-title-seo">RNAscope™ Applications</h2></div><div class="content-container container newapplication"><div id="node-104794" class="node node-application" about="/science/applications/disease-areas/zika-virus-research" typeof="sioc:Item foaf:Document"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs application-bxslider" id="myTab"><li><a href="/science/applications/research-areas/infectious-diseases">Infectious Diseases</a></li><li class="active"><a href="/science/applications/disease-areas/zika-virus-research" class="active">Zika Virus</a></li><li><a href="/science/applications/research-areas/hiv-siv">HIV & SIV</a></li><li><a href="/science/applications/research-areas/covid-19-coronavirus">COVID-19 Coronavirus</a></li></ul></div><div class="tab-content"><div id="tab0" class="tab-pane fade in active profile"><h1 class="top-profile">Zika Virus Research</h1><div class="sample-image"><div class="loader-image-gallery"></div><div id="film_roll" class="sample-slider"><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/ZikaMR766Uganda%20strainLC0025201Positivestrand_0_0.jpg?itok=WeNRwA9O" width="765" height="451" alt=" Detection of Zika viral genomic RNA with RNAscope probe #464531 (red punctate dots). The Vero cells sample was infected with ZIKV, MR766 strain. Data courtesy of Dr. Noriko Nakajima, National Institute of Infectious Disease, Japan "><p class="slider-below-text"> Detection of Zika viral genomic RNA with RNAscope probe #464531 (red punctate dots). The Vero cells sample was infected with ZIKV, MR766 strain. Data courtesy of Dr. Noriko Nakajima, National Institute of Infectious Disease, Japan</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/ZikaMR766UgandastrainLC0025201Negstrand_0.jpg?itok=yobS3ePC" width="765" height="451" alt="Detection of Zika viral cRNA (- strand) with RNAscope™ probe #464541 ( red punctate dots). The Vero cells sample was infected with ZIKV, MR766 strain. Data courtesy of Dr. Noriko Nakajima, National Institute of Infectious Disease Japan "><p class="slider-below-text"> Detection of Zika viral cRNA (- strand) with RNAscope™ probe #464541 ( red punctate dots). The Vero cells sample was infected with ZIKV, MR766 strain. Data courtesy of Dr. Noriko Nakajima, National Institute of Infectious Disease Japan</p></div></div><style type="text/css"> .loader-image-gallery { position: absolute; left: 0px; top: 0px; width: 100%; height: 100%; z-index: 9999; background: url('/sites/default/files/loading_apple.gif') 50% 35% no-repeat rgb(249,249,249); background-size: 100px; opacity: .8; } .sample-image { position: relative; } </style> <script type="text/javascript"> jQuery(document).ready(function($) { // $('#film_roll').hide(); function preloader(){ $('.loader-image-gallery').hide(); $('#film_roll').show(); } window.onload = preloader; }); </script> </div><div class="profile-content application_node_104794"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>As a result of the Zika virus outbreak, researchers are accelerating research into the biology of the virus and the pathology of human infection with the goals of understanding the causes of the clinical syndrome, developing reliable detection methods and finding effective treatments. </p><h2>Why use RNAscope™ assay for zika virus research?</h2><p>RNAscope™ ISH, an innovated ISH assay, offers researchers a robust and accurate method to detect even low levels of viral RNA in virtually any tissue samples. The ability to detect the virus within the context of the infected tissue will advance the understanding of the zika viral biology. </p><p><strong>Morphologic context - </strong>Performed <em>in situ,</em> RNAscope™ assay preserves the morphology of the infected tissues, enabling detection of the viral RNA in the morphological context. <a href="http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31175-5">Miner et al., 2016</a> demonstrated this in detection of Zika in eyes of mouse fetuses</p><p><strong>Proven for viral detection - </strong>Numerous publications citing the use of RNAscope™ <em>in situ</em> hybridization in viral studies spanning HPV, EPV, HIV, SIV, HCV, MERS etc. RNAscope™ assay enables virologists to bypass time consuming and often non-yielding antibody development. </p><p><strong>Proven for viral replication detection and localization - </strong><a href="http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31175-5">read Bhatnagar J et al 2017</a></p><p><strong>Versatile probe design for low viral count - </strong>When working with zika or other viruses of extremely low copy number, ACD can customize the probe design strategy to offset this challenge; for example by designing probes with more than the typical 20 Z probe pairs.</p><p><strong>Specificity - </strong>The highly specific, proprietary RNAscope™ double Z probe design, eliminates cross reactivity with other flavivirus RNA, enabling reliable differentiation from highly homologous viruses such as dengue.</p><p><strong>Sensitivity - </strong>The ultrahigh sensitivity of RNAscope™ assay and ability to detect single RNA molecules makes it ideal for <em>in situ </em>detection of low level tissue infection. <a href="http://www.ncbi.nlm.nih.gov/pubmed/27681334">Read Rosenberg et al (2017</a>) </p></div></div></div><div class="view view-application view-id-application view-display-id-block_8 view-dom-id-48f5d03467cee2ff222d05e42238dd03"></div><div class="view view-application view-id-application view-display-id-block_9 view-dom-id-74b29736e5ca1c04f1736fec126cecf6"><div class="view-content"><style type="text/css"> .view-id-application.view-display-id-block_9 .row.immuno-watch { margin-top: 15px; margin-bottom: 15px; } </style></div></div></div><div class="sample-image"><div class="profile-bottom"></div></div><div class="spotlight"><div class="profile-bottom spot"><h2><span><strong>Featured Publications</strong></span></h2><p>A number of key customers have used the RNAscope™ ISH Assay in their published research findings. </p><p> </p><table border="1" cellpadding="1" cellspacing="1" class="classification full"><thead><tr><th style="width:30%;"><span style="font-weight: normal;">Date/Journal</span></th><th style="width:70%;"><span style="font-weight: normal;">Title and details</span></th></tr></thead><tbody><tr><td><p><strong>July 2016</strong></p><p><a href="http://www.cbsnews.com/news/zika-virus-linked-to-miscarriage/" target="_blank"><font color="#333333"><img alt="" src="/sites/default/files/NewsImage-175.jpg" /></font></a></p><p><a href="http://www.cbsnews.com/news/zika-virus-linked-to-miscarriage/" target="_blank"><font color="#333333">Read it in the news</font></a></p><p> </p></td><td><p><strong>New England Journal of Medicine</strong></p><p><font color="#333333"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27463941" target="_blank">Miscarriage associated with Zika virus infection</a></font></p><p>van der Eijk AA <em>et al</em> detected ZIKA viral RNA with the use of virus-specific RNAscope™ probes that revealed staining in the amniotic epithelium and the fetal mesenchymal cells, particularly in the perichondrium.</p></td></tr><tr><td><p><strong>SEPT 2016</strong></p><p><a href="https://www.youtube.com/watch?v=Byu9xNGeGFY" target="_blank"><font color="#333333"><img alt="" src="/sites/default/files/cell-reports-175.png" /></font></a></p><p><a href="https://www.youtube.com/watch?v=Byu9xNGeGFY" target="_blank"><font color="#333333">See the story</font></a></p></td><td><p><strong>Cell Reports</strong></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27612415" target="_blank"><font color="#333333">Zika virus infection in mice causes panuveitis with shedding of virus in tears</font></a></p><p><a href="http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31175-5">Miner <em>et al</em>., 2016</a> detected Zika virus in eyes of mouse fetuses - specifically in the retina, optic nerve and cornea <a href="http://www.cell.com/action/showImagesData?pii=S2211-1247%2816%2931175-5">(figure 6)</a>. </p></td></tr><tr><td><p><strong>SEPT 2016</strong></p></td><td><p><strong>Archives of Path & Lab Med</strong></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27681334" target="_blank">Placental pathology of Zika virus: viral infection of the placenta induces villous stromal macrophage proliferation and hyperplasia</a></p><p>Rosenberg <em>et al </em>(2017) applied <em>i</em><em>n situ </em>hybridization using a Zika virus RNAscope™ Probe <a href="/search/site/463781/cms/probes">463781</a> demonstrated scattered, strongly positive staining cells within the villous stroma of the chorionic villi (Figure 4), which were presumably Hofbauer cells.</p></td></tr><tr><td><p><strong>OCT 2016</strong></p><p><a href="http://medicalxpress.com/news/2016-10-zika-virus-blood-macaques.html" target="_blank"><font color="#333333"><img alt="" src="/sites/default/files/NewsImage-175.jpg" /></font></a></p><p><a href="http://medicalxpress.com/news/2016-10-zika-virus-blood-macaques.html" target="_blank"><font color="#333333">Read it in the news</font></a></p></td><td><p><strong>Nature Medicine</strong></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27694931" target="_blank"><span style="color:#0000FF;">Zika viral dynamics and shedding in rhesus and cynomolgus macaques</span></a></p><p><a href="http://www.nature.com/nm/journal/v22/n12/full/nm.4206.html#auth-1">Osuna</a> <em>et al</em> used RNAscope™ ISH assay to study ZIKV dynamics and tropism in tissues.  Multiple anatomic tissues from each animal were prepared and analyzed by RNAscope, including lymph nodes (LNs) (inguinal, axillary, mesenteric), male genital tract (seminal vesicles, testes, prostate), female genital tract (uterus, ovaries), gastrointestinal tract (jejunum, colon), liver, kidney, bladder, lung, bone marrow and CNS (parietal lobe, basal nuclei, hippocampus, cerebellum) <a href="http://www.nature.com/nm/journal/v22/n12/full/nm.4206.html">figure 4</a>. The RNAscope probes with 87 Z pairs were designed against a consensus sequence comprise of 4 different genomes. </p></td></tr><tr><td><p><strong>OCT 2016</strong></p><p><a href="https://www.youtube.com/watch?v=hSGPi-vB768" target="_blank"><font color="#333333"><img alt="" src="/sites/default/files/story-175.png" /></font></a></p><p><a href="https://www.youtube.com/watch?v=Byu9xNGeGFY" target="_blank"><font color="#333333">See the story</font></a></p></td><td><p><strong><font color="#333333">Nature</font></strong></p><p><font color="#333333"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27798603" target="_blank">Zika virus infection damages the testes in mice</a></font></p><p><a href="http://www.nature.com/nature/journal/v540/n7633/full/nature20556.html">Govero</a> <em>et al</em> (2016) used RNAscope™ Probe Catalog #<a href="https://acdbio.com/search/site/%252A467871%252A/cms/probes">467871</a> to determine Zika viral tropism.  RNAscope <em>in situ </em>hybridization (ISH) was applied to detect viral RNA at in cells of the testis at day 7 after infection (Fig 1), day 14 (Fig 2), day 21 (Fig 3) and day 28 (Fig 4). Cells of the testis include mature lumenal sperm, and on cilia layering the inner lumen of the epididymis. </p></td></tr><tr><td><p><strong>NOV 2016</strong></p><p><a href="http://www.techtimes.com/articles/185113/20161108/new-antibody-protects-pregnant-women-fetuses-against-zika-virus.htm" target="_blank"><font color="#333333"><img alt="" src="/sites/default/files/NewsImage-175.jpg" /></font></a></p><p><a href="http://www.techtimes.com/articles/185113/20161108/new-antibody-protects-pregnant-women-fetuses-against-zika-virus.htm" target="_blank"><font color="#333333">Read it in the news</font></a></p></td><td><p><strong><font color="#333333">Nature</font></strong></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27819683" target="_blank"><font color="#333333">Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice.</font></a></p><p>Sapparapu <em>et al</em> (2016) used RNAscope Probe 467771</p><p> </p></td></tr><tr><td><p><strong>DEC 2016</strong></p><p><a href="https://www.nytimes.com/2016/12/13/health/zika-virus-baby-brain-defects.html?_r=0" target="_blank"><font color="#333333"><img alt="" src="/sites/default/files/NewsImage-175.jpg" /></font></a></p><p><a href="https://www.nytimes.com/2016/12/13/health/zika-virus-baby-brain-defects.html?_r=0" target="_blank"><font color="#333333">Read it in the news</font></a></p></td><td><p><strong>Emerging Infectious Disease</strong></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27959260" target="_blank"><font color="#333333">Zika virus RNA replication and persistence in brain and placental tissue</font></a></p><p>Bhatnagar J <em>et al</em> (2017) used RNAscope Probes <a href="https://acdbio.com/search/site/%252A468361%252A/cms/probes">468361</a> and <a href="https://acdbio.com/search/site/%252AV-ZIKA-O4-sense%252A/cms/probes">469541</a> (designed against the sense and anti-sense strands) and demonstrated not only detection of the virus but also detection of viral replication. They isolated the viral replication to neuronal cells in fetal brain tissues.</p></td></tr><tr><td><p><strong>JAN 2017</strong></p><p> </p></td><td><p><strong>PLOS</strong></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=28068342" target="_blank">Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon</a></p><p>Smith (2017) and a team of researchers at the United States Army Medical Research Institute of Infectious Diseases applied RNAscope 2.5 HD RED to visualize Zika Virus in mouse models.  Their goal is to development of well-characterized animal models that recapitulate human disease. RNAscope ISH data was presented throughout the paper in Fig 3 (ZIKV in Cerebrum) . Fig 4 (ZIKV in hippocampus), Fig 5 (ZIKV in spinal cord), Fig 7 (ZIKV in spleen). Using this model, they provide a detailed description of the ZIKV-associated pathologic changes, which mirrors the neuropathogenic properties of ZIKV in humans.</p></td></tr></tbody></table></div><div class="profile-bottom publication"><p><span style="font-size: 18px;"><strong>ZIKA Virus Genome  Structure</strong></span></p><p>The zika virus is a sense single-stranded RNA virus (sssRNA)  (also described as SSRNA positive sense virus, no DNA stage). Its  >10,000 bases code for three structural proteins (capsid (C), precursor membrane (prM), envelope (E) and seven nonstructural proteins (NS). The NS2A, NS2B, NS4A, and NS4B proteins are smaller, hydrophobic proteins while NS1, NS3, and NS5 are large and highly conserved.  </p><p>ACD can design RNAscope™ ISH probes against unique regions of these publically available sequences or proprietary sequences that you may have. 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576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div class="row" style="border-bottom: none;"><div class="col-md-6"> <a href="/about/distributors" class="meet-out-sales-team" title="See Distributors">See Distributors</a></div></div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactpharma"><div class="supportform-con"><div class="contact-tab-form supportform-con"><form id="mktoForm_9817"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9817);</script> </div></div></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $("#web-to-case1").validate({ // Specify the validation rules rules: { fname: "required", lname: "required", phone:"required", email: { required: true, email: true }, company: "required", case_captcha: "required" }, // Specify the validation error messages messages: { fname: "Please enter your First Name", lname: "Please enter your Last Name", email: "Please enter your email address", phone: "Please enter your 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