CINXE.COM

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$('.clinical-readmore').readmore({ speed: 500, moreLink: '<a href="#" class="readmore">Read More <span>+</span></a>', lessLink: '<a href="#" class="readless">Read Less <span>-</span></a>' }); }); </script> <style> .clinical-readmore{ max-height: 120px; } </style><div class="page-main-container "><div class="banner-container sticky"> <img class="img-banner" src="https://acdbio.com/sites/default/files/science-banner.jpg"><h2 class="general-title">RNAscope™ Applications</h2></div><div class="content-container container newapplication"><div id="node-102194" class="node node-application" about="/science/applications/animal-models/preclinical-safety-assessment" typeof="sioc:Item foaf:Document"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs application-bxslider" id="myTab"><li><a href="/science/applications/animal-models/virtually-any-species">Virtually ANY Species</a></li><li class="active"><a href="/science/applications/animal-models/preclinical-safety-assessment" 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src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/20150710_Dog-Mac2_Ovary_std_Cl-PECAM1_LS2p5_0.jpg?itok=wEqnjLDx" width="765" height="451" alt="Expression of Pecam1 in dog ovary FFPE tissue, RNA in situ hybridization (ISH) using RNAscope™ 2.5 LS Reagent Kit-BROWN"><p class="slider-below-text"> Expression of Pecam1 in dog ovary FFPE tissue, RNA in situ hybridization (ISH) using RNAscope™ 2.5 LS Reagent Kit-BROWN</p></div></div><style type="text/css"> .loader-image-gallery { position: absolute; left: 0px; top: 0px; width: 100%; height: 100%; z-index: 9999; background: url('/sites/default/files/loading_apple.gif') 50% 35% no-repeat rgb(249,249,249); background-size: 100px; opacity: .8; } .sample-image { position: relative; } </style> <script type="text/javascript"> jQuery(document).ready(function($) { // $('#film_roll').hide(); function preloader(){ $('.loader-image-gallery').hide(); $('#film_roll').show(); } window.onload = preloader; }); </script> </div><div class="profile-content application_node_102194"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>Preclinical drug safety assessment in animal models is well established as a routine part of pharmaceutical drug development to evaluate the potential safety issues associated with novel therapeutic targets and corresponding lead molecules. Immunohistochemistry (IHC) is the method of choice for assessment of targets and toxicity-related biomarkers. However, systematic application of IHC is hindered by inconsistent performance of commercial antibodies, time-consuming antibody development and validation and general lack of reagents for some animal models. <br />The RNAscope™ technology enables detection of almost any RNA biomarker with single-molecule sensitivity and high specificity in formalin-fixed paraffin-embedded (FFPE) tissues. It provides a fast, efficient and universal solution to characterize tissue distribution of drug target and biomarker expression in a highly specific and sensitive manner.</p><p> </p><div class="clinical-readmore"><h2>ACD Drug Safety Assessment Study</h2><p>ACD conducted a study using 25 FFPE tissues (provided by Pfizer, Inc.) from 3 species (<em>cynomolgus</em> monkey, dog and rat) to:</p><p>- Identify the optimal pretreatment conditions for different tissues in different species<br />- Identify positive control probe for each tissue<br />- Detect specific RNA markers (cell-type, proliferation and apoptosis biomarkers)</p><p>These results show the utility and efficiency of RNAscope as a platform for target and safety marker assessment in preclinical animal studies.<br /> </p><p>Want to learn more about this study?<br />- Watch the poster presentation and download the poster<br />- Download the application review<br />- Download the appendix to access the complete study data (123 pages with more than 440 data points)</p></div></div></div></div><div class="view view-application view-id-application view-display-id-block_8 view-dom-id-0b88fa6980dbdd8bac4595ea2d280b51"></div><div class="view view-application view-id-application view-display-id-block_9 view-dom-id-1def0de158162a766ff8441180e4e9e3"><div class="view-content"><style type="text/css"> .view-id-application.view-display-id-block_9 .row.immuno-watch { margin-top: 15px; margin-bottom: 15px; } </style></div></div></div><div class="sample-image"><div class="profile-bottom"><h3>Drug Safety Assessment Poster Presentation</h3><p> </p><div class="row review"><div class="col-md-6"><img alt="" src="/sites/default/files/Drug%20safety%20assessment%20sutdy%20vide_0.jpg" style="height:154px; width:300px" /></div><div class="col-md-6 download-pdf-app"><h3>STP Poster 2015<br />"Fully Automated RNA <em>in situ</em> Hybridization for Proliferation and Apoptosis-related Biomarkers in Preclinical Animal Model Tissue Panels using RNAscope™ 2.5 LS Assay"</h3><div class="row"><div class="col-md-6 marketo-container"><form id="mktoForm_10016" rel="10016"> </form><p><a class="link marketo-popup" href="#">Watch Video</a></p></div><div class="col-md-6 marketo-container"><form id="mktoForm_9964" rel="9964"> </form><p><a class="link marketo-popup" href="#" target="_blank">Download Poster</a></p></div></div></div><div class="clear"> </div></div><h3>Application Note</h3><div class="row review app-note"><div class="col-md-6"><img src="/sites/default/files/Drug_Safety_App_Note_0.png" /></div><div class="col-md-6 download-pdf-app"><h3>Application Note "Robust detection of RNA biomarkers for drug safety assessment in preclinical animal models by fully automated RNAscope™ 2.5 LS Assay"</h3></div><div class="marketo-container download-pdf"><form id="mktoForm_9798" rel="9798"> </form><p><a class="down-pdf-btn marketo-popup" href="#">Download pdf</a></p></div></div><h3>Appendix</h3><div class="row review app-appendix"><div class="col-md-6"><img src="/sites/default/files/Drug_Saftey_Appendix_0.png" /></div><div class="col-md-6 download-pdf-app"><h3>Appendix "Robust detection of RNA biomarkers for drug safety assessment in preclinical animal models by fully automated RNAscope™ 2.5 LS Assay"</h3></div><div class="marketo-container download-pdf"><form id="mktoForm_9963" rel="9963"> </form><p><a class="down-pdf-btn marketo-popup" href="#">Download pdf</a></p></div><div class="clear"> </div></div></div></div><div class="spotlight"></div></div><div class="video-popup-show" id="video-popup-show"> <a class="video-popup-close"> <img class="video-popup-show_close" src="/sites/all/themes/acd/images/lightbox-close-btn.jpg" class="img"> </a><iframe width="660" height="415" class="video-preview" src="" frameborder="0" allowfullscreen></iframe></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { var windowsize = $(window).width(); 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relative; bottom: 3%; background-color: transparent; width: 32px; height: 32px; font-size: 23px; color: #FFFFFF; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus { outline: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus::before { content: " "; position: absolute; top: 11%; left: 7%; width: 85%; height: 85%; background-color: rgba(255, 255, 255, 0.2); border-radius: 4px; pointer-events: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:active, .embeddedServiceCloseIcon:hover { background-color: #FFFFFF; color: rgba(0, 0, 0, 0.7); opacity: 0.7; } .embeddedServiceInvitation>.embeddedServiceInvitationBody { background-color: #FFFFFF; max-height: 110px; min-width: 260px; margin: 0 8px; font-size: 14px; line-height: 20px; overflow: auto; } .embeddedServiceInvitationBody p { color: #333333; padding: 8px; margin: 12px 0; } .embeddedServiceInvitation>.embeddedServiceInvitationFooter { width: inherit; color: #FFFFFF; text-align: right; background-color: #FFFFFF; padding: 10px; max-height: none; border-bottom-left-radius: 8px; border-bottom-right-radius: 8px; margin-bottom: 10px; } .embeddedServiceInvitationFooter>.embeddedServiceActionButton { font-size: 14px; max-height: 40px; border: none; border-radius: 4px; padding: 10px; margin: 4px; text-align: center; text-decoration: none; display: inline-block; cursor: pointer; } .embeddedServiceInvitationFooter>#acceptInvite { background-image: none; background-color: #005f9e; color: #FFFFFF; } .embeddedServiceInvitationFooter>#rejectInvite { background-image: none; background-color: #FFFFFF; color: #005f9e; } </style>   <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext"> <img id="embeddedServiceAvatar"></img> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> <style type='text/css'> #snapins_invite { background-color: #FFFFFF; font-family: "Arial", sans-serif; overflow: visible; border-radius: 8px; visibility: hidden; } .embeddedServiceInvitation { background-color: transparent; max-width: 290px; max-height: 210px; -webkit-box-shadow: 0 7px 12px rgba(0,0,0,0.28); -moz-box-shadow: 0 7px 12px rgba(0,0,0,0.28); box-shadow: 0 7px 12px rgba(0,0,0,0.28); } @media only screen and (min-width: 48em) { /*mobile*/ .embeddedServiceInvitation { max-width: 332px; max-height: 210px; } } .embeddedServiceInvitation > .embeddedServiceInvitationHeader { width: inherit; height: 32px; line-height: 32px; padding: 10px; color: #FFFFFF; background-color: #222222; overflow: initial; display: flex; justify-content: space-between; align-items: stretch; border-top-left-radius: 8px; border-top-right-radius: 8px; } .embeddedServiceInvitationHeader #embeddedServiceAvatar { width: 32px; height: 32px; border-radius: 50%; } .embeddedServiceInvitationHeader .embeddedServiceTitleText { font-size: 18px; color: #FFFFFF; overflow: hidden; word-wrap: normal; white-space: nowrap; text-overflow: ellipsis; align-self: stretch; flex-grow: 1; max-width: 100%; margin: 0 12px; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon { border: none; border-radius: 3px; cursor: pointer; position: relative; bottom: 3%; background-color: transparent; width: 32px; height: 32px; font-size: 23px; color: #FFFFFF; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus { outline: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus::before { content: " "; position: absolute; top: 11%; left: 7%; width: 85%; height: 85%; background-color: rgba(255, 255, 255, 0.2); border-radius: 4px; pointer-events: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:active, .embeddedServiceCloseIcon:hover { background-color: #FFFFFF; color: rgba(0,0,0,0.7); opacity: 0.7; } .embeddedServiceInvitation > .embeddedServiceInvitationBody { background-color: #FFFFFF; max-height: 110px; min-width: 260px; margin: 0 8px; font-size: 14px; line-height: 20px; overflow: auto; } .embeddedServiceInvitationBody p { color: #333333; padding: 8px; margin: 12px 0; } .embeddedServiceInvitation > .embeddedServiceInvitationFooter { width: inherit; color: #FFFFFF; text-align: right; background-color: #FFFFFF; padding: 10px; max-height: 50px; border-bottom-left-radius: 8px; border-bottom-right-radius: 8px; } .embeddedServiceInvitationFooter > .embeddedServiceActionButton { font-size: 14px; max-height: 40px; border: none; border-radius: 4px; padding: 10px; margin: 4px; text-align: center; text-decoration: none; display: inline-block; cursor: pointer; } .embeddedServiceInvitationFooter > #acceptInvite { background-color: #005290; color: #FFFFFF; } .embeddedServiceInvitationFooter > #rejectInvite { background-color: #FFFFFF; color: #005290; } </style>   <input type="hidden" name="liveagent.prechat.findorcreate.map.doFind:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.isExactMatch:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.doCreate:Contact" value="LastName,true;FirstName,true;Email,true" /> <script type='text/javascript'> (function() { document.getElementById('closeInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; document.getElementById('rejectInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; // use this API call to reject invitations document.getElementById('acceptInvite').onclick = function() { embedded_svc.liveAgentAPI.startChat({ directToButtonRouting: { buttonId: "5733t000000cVk9" }, extraPrechatInfo: [], extraPrechatFormDetails: [] }); }; // use this API call to start chat from invitations document.addEventListener('keyup', function(event) { if (event.keyCode == 27) { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }}) })(); </script>  <script type='text/javascript' src='https://service.force.com/embeddedservice/5.0/esw.min.js'></script> <script type='text/javascript'> var initESW = function(gslbBaseURL) { embedded_svc.settings.displayHelpButton = true; //Or false embedded_svc.settings.language = ''; //For example, enter 'en' or 'en-US' embedded_svc.settings.defaultMinimizedText = 'Chat now'; //(Defaults to Chat with an Expert) embedded_svc.settings.disabledMinimizedText = 'Leave a message'; //(Defaults to Agent Offline) embedded_svc.settings.autoOpenPostChat = true; //embedded_svc.settings.loadingText = ''; //(Defaults to Loading) //embedded_svc.settings.storageDomain = 'yourdomain.com'; //(Sets the domain for your deployment so that visitors can navigate subdomains during a chat session) // Settings for Chat embedded_svc.settings.directToButtonRouting = function (prechatFormData) { if (prechatFormData[4].value === "Technical Service") return "5733t000000XZAM"; if (prechatFormData[4].value === "Customer Care") return "5733t000000XZAH"; }; embedded_svc.settings.prepopulatedPrechatFields = { OmniURL__c: window.location.href, ChooseaDepartment__c: 'Technical Service' }; //Sets the auto-population of pre-chat form fields embedded_svc.settings.extraPrechatFormDetails = [{ "label":"Source Domain", "value":window.location.href, "transcriptFields":[ "Source_Domain__c" ], "displayToAgent":true }]; //embedded_svc.settings.fallbackRouting = []; //An array of button IDs, user IDs, or userId_buttonId embedded_svc.settings.offlineSupportMinimizedText = 'Leave a message'; //(Defaults to Contact Us) embedded_svc.settings.enabledFeatures = ['LiveAgent']; embedded_svc.settings.entryFeature = 'LiveAgent'; embedded_svc.init( 'https://biotechne.my.salesforce.com', 'https://biotechne.my.salesforce-sites.com/LiveAgent', gslbBaseURL, '00D500000006gkl', 'ACD_Chat_Automated', { baseLiveAgentContentURL: 'https://c.la1-c1-ia5.salesforceliveagent.com/content', deploymentId: '572380000004CqL', buttonId: '5733t000000cVk9', baseLiveAgentURL: 'https://d.la1-c1-ia5.salesforceliveagent.com/chat', eswLiveAgentDevName: 'EmbeddedServiceLiveAgent_Parent04I3t000000Y7zbEAC_175bb741b99', isOfflineSupportEnabled: true } ); }; if (!window.embedded_svc) { var s = document.createElement('script'); s.setAttribute('src', 'https://biotechne.my.salesforce.com/embeddedservice/5.0/esw.min.js'); s.onload = function() { 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