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Up-regulated DDX39 in Adrenocortical Carcinoma Is Associated With Patient Survival | Anticancer Research
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Delinasios), All rights reserved." /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Description" content="Background/Aim: Adrenocortical carcinoma is a very rare tumor characterized by poor prognosis and high mortality. The origin of this tumor is primarily the adrenal cortex. The 5-year overall survival rate of patients with adrenocortical carcinoma has not improved despite therapeutic advances. Early detection of this malignancy remains difficult, and no standard curative therapy currently exists. Therefore, it is important to understand the biology of adrenocortical carcinoma, and to identify prognostic biomarkers and molecular targets for its therapy. DDX39 is an Asp-Glu-Ala-Asp (DEAD)-box RNA helicase, which is required for transcription, splicing and transport of mRNA. There are some reports about overexpression of DDX39 in tumor tissues and cells (lung squamous cell cancer, gastrointestinal stromal tumor, urinary bladder cancer, malignant pleural mesothelioma). However, the clinicopathological involvement of DDX39 in adrenocortical carcinoma has not yet been documented. Materials and Methods: The GEPIA, GEPIA2, and UALCAN platforms were used to analyze DDX39 mRNA expression and survival in patients with adrenocortical carcinoma. Results: DDX39 was found to be significantly up-regulated in adrenocortical carcinoma tissues, and this up-regulation inversely correlated with prolonged patient survival. Conclusion: DDX39 may be a potential prognostic biomarker in patients with adrenocortical carcinoma." /> <meta name="DC.Contributor" content="YOSHIATSU TANAKA" /> <meta name="DC.Contributor" content="SHIN-NOSUKE YAMASHITA" /> <meta name="DC.Contributor" content="SHAJEDUL ISLAM" /> <meta name="DC.Contributor" content="TAKAO KITAGAWA" /> <meta name="DC.Contributor" content="KAZUHIRO TOKUDA" /> <meta name="DC.Contributor" content="DURGA PAUDEL" /> <meta name="DC.Contributor" content="SARITA GIRI" /> <meta name="DC.Contributor" content="TOHRU OHTA" /> <meta name="DC.Contributor" content="FUMIYA HARADA" /> <meta name="DC.Contributor" content="HIROKI NAGAYASU" /> <meta name="DC.Contributor" content="YASUHIRO KURAMITSU" /> <meta name="article:published_time" content="2025-02-01" /> <meta name="article:section" content="Clinical Studies" /> <meta name="citation_title" content="Up-regulated DDX39 in Adrenocortical Carcinoma Is Associated With Patient Survival" /> <meta name="citation_abstract" lang="en" content="<p>Background/Aim: Adrenocortical carcinoma is a very rare tumor characterized by poor prognosis and high mortality. The origin of this tumor is primarily the adrenal cortex. The 5-year overall survival rate of patients with adrenocortical carcinoma has not improved despite therapeutic advances. Early detection of this malignancy remains difficult, and no standard curative therapy currently exists. Therefore, it is important to understand the biology of adrenocortical carcinoma, and to identify prognostic biomarkers and molecular targets for its therapy. DDX39 is an Asp-Glu-Ala-Asp (DEAD)-box RNA helicase, which is required for transcription, splicing and transport of mRNA. There are some reports about overexpression of DDX39 in tumor tissues and cells (lung squamous cell cancer, gastrointestinal stromal tumor, urinary bladder cancer, malignant pleural mesothelioma). However, the clinicopathological involvement of DDX39 in adrenocortical carcinoma has not yet been documented. Materials and Methods: The GEPIA, GEPIA2, and UALCAN platforms were used to analyze DDX39 mRNA expression and survival in patients with adrenocortical carcinoma. Results: DDX39 was found to be significantly up-regulated in adrenocortical carcinoma tissues, and this up-regulation inversely correlated with prolonged patient survival. Conclusion: DDX39 may be a potential prognostic biomarker in patients with adrenocortical carcinoma.</p>" /> <meta name="citation_journal_title" content="Anticancer Research" /> <meta name="citation_publisher" content="International Institute of Anticancer Research" /> <meta name="citation_publication_date" content="2025/02/01" /> <meta name="citation_mjid" content="anticanres;45/2/811" /> <meta name="citation_id" content="45/2/811" /> <meta name="citation_public_url" content="https://ar.iiarjournals.org/content/45/2/811" /> <meta name="citation_abstract_html_url" content="https://ar.iiarjournals.org/content/45/2/811.abstract" /> <meta name="citation_full_html_url" content="https://ar.iiarjournals.org/content/45/2/811.full" /> <meta name="citation_pdf_url" content="https://ar.iiarjournals.org/content/anticanres/45/2/811.full.pdf" /> <meta name="citation_issn" content="0250-7005" /> <meta name="citation_issn" content="1791-7530" /> <meta name="citation_doi" content="10.21873/anticanres.17469" /> <meta name="citation_pmid" content="39890176" /> <meta name="citation_volume" content="45" /> <meta name="citation_issue" content="2" /> <meta name="citation_article_type" content="Research Article" /> <meta name="citation_section" content="Clinical Studies" /> <meta name="citation_firstpage" content="811" /> <meta name="citation_lastpage" content="815" /> <meta name="citation_author" content="YOSHIATSU TANAKA" /> <meta name="citation_author_institution" content="Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="SHIN-NOSUKE YAMASHITA" /> <meta name="citation_author_institution" content="Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="SHAJEDUL ISLAM" /> <meta name="citation_author_institution" content="Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="TAKAO KITAGAWA" /> <meta name="citation_author_institution" content="Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="KAZUHIRO TOKUDA" /> <meta name="citation_author_institution" content="Graduate School of Health and Welfare, Yamaguchi Prefectural University, Yamaguchi, Japan" /> <meta name="citation_author" content="DURGA PAUDEL" /> <meta name="citation_author_institution" content="Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="SARITA GIRI" /> <meta name="citation_author_institution" content="Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="TOHRU OHTA" /> <meta name="citation_author_institution" content="Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="FUMIYA HARADA" /> <meta name="citation_author_institution" content="Division of Oral and Maxillofacial Surgery School of Dentistry, and Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="HIROKI NAGAYASU" /> <meta name="citation_author_institution" content="Division of Oral and Maxillofacial Surgery School of Dentistry, and Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author" content="YASUHIRO KURAMITSU" /> <meta name="citation_author_institution" content="Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author_institution" content="School of Medical Technology, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan" /> <meta name="citation_author_email" content="climates@hoku-iryo-u.ac.jp" /> <meta name="citation_reference" content="citation_journal_title=Front Cell Dev Biol;citation_author=R. 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Wang;citation_title=DDX39 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with clear cell renal cell carcinoma;citation_pages=3158-3172;citation_volume=17;citation_year=2021;citation_issue=12;citation_pmid=34421357;citation_doi=10.7150/ijbs.62553" /> <meta name="twitter:title" content="Up-regulated DDX39 in Adrenocortical Carcinoma Is Associated With Patient Survival" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:image" content="https://ar.iiarjournals.org/sites/default/files/highwire/anticanres/45/2.cover-source.jpg" /> <meta name="twitter:description" content="Background/Aim: Adrenocortical carcinoma is a very rare tumor characterized by poor prognosis and high mortality. The origin of this tumor is primarily the adrenal cortex. The 5-year overall survival rate of patients with adrenocortical carcinoma has not improved despite therapeutic advances. Early detection of this malignancy remains difficult, and no standard curative therapy currently exists. Therefore, it is important to understand the biology of adrenocortical carcinoma, and to identify prognostic biomarkers and molecular targets for its therapy. DDX39 is an Asp-Glu-Ala-Asp (DEAD)-box RNA helicase, which is required for transcription, splicing and transport of mRNA. There are some reports about overexpression of DDX39 in tumor tissues and cells (lung squamous cell cancer, gastrointestinal stromal tumor, urinary bladder cancer, malignant pleural mesothelioma). However, the clinicopathological involvement of DDX39 in adrenocortical carcinoma has not yet been documented. Materials and Methods: The GEPIA, GEPIA2, and UALCAN platforms were used to analyze DDX39 mRNA expression and survival in patients with adrenocortical carcinoma. Results: DDX39 was found to be significantly up-regulated in adrenocortical carcinoma tissues, and this up-regulation inversely correlated with prolonged patient survival. Conclusion: DDX39 may be a potential prognostic biomarker in patients with adrenocortical carcinoma." /> <meta name="og-title" property="og:title" content="Up-regulated DDX39 in Adrenocortical Carcinoma Is Associated With Patient Survival" /> <meta name="og-url" property="og:url" content="https://ar.iiarjournals.org/content/45/2/811" /> <meta name="og-site-name" property="og:site_name" content="Anticancer Research" /> <meta name="og-description" property="og:description" content="Background/Aim: Adrenocortical carcinoma is a very rare tumor characterized by poor prognosis and high mortality. The origin of this tumor is primarily the adrenal cortex. The 5-year overall survival rate of patients with adrenocortical carcinoma has not improved despite therapeutic advances. Early detection of this malignancy remains difficult, and no standard curative therapy currently exists. Therefore, it is important to understand the biology of adrenocortical carcinoma, and to identify prognostic biomarkers and molecular targets for its therapy. DDX39 is an Asp-Glu-Ala-Asp (DEAD)-box RNA helicase, which is required for transcription, splicing and transport of mRNA. There are some reports about overexpression of DDX39 in tumor tissues and cells (lung squamous cell cancer, gastrointestinal stromal tumor, urinary bladder cancer, malignant pleural mesothelioma). However, the clinicopathological involvement of DDX39 in adrenocortical carcinoma has not yet been documented. Materials and Methods: The GEPIA, GEPIA2, and UALCAN platforms were used to analyze DDX39 mRNA expression and survival in patients with adrenocortical carcinoma. Results: DDX39 was found to be significantly up-regulated in adrenocortical carcinoma tissues, and this up-regulation inversely correlated with prolonged patient survival. Conclusion: DDX39 may be a potential prognostic biomarker in patients with adrenocortical carcinoma." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://ar.iiarjournals.org/sites/default/files/highwire/anticanres/45/2.cover-source.jpg" /> <link rel="shortlink" href="/node/83124" /> <link rel="shortcut icon" href="https://ar.iiarjournals.org/sites/default/files/images/favicon.ico" type="image/vnd.microsoft.icon" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <title>Up-regulated DDX39 in Adrenocortical Carcinoma Is Associated With Patient Survival | Anticancer Research</title> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__QEy_BpbtMcsqv3xURK855GSs2fFjOibU10yA758Mn4c__NucWi_bEk5E3BNVDtTt2nhiPtE1A5I24YwRDQ2fojJ0__FTZ25lEcrtnzSW3JzKpn0j1z_ccWiSdhuJwjpWHa4ec.css" media="all" /> <link type="text/css" rel="stylesheet" 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class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a"> <div class="highwire-cite-overline"><span class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Clinical Studies</span></span></div> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="anticanres;45/2/811" data-atom-uri="/anticanres/45/2/811.atom" data-request-view="full"></span></div> <h1 class="highwire-cite-title" id="page-title">Up-regulated DDX39 in Adrenocortical Carcinoma Is Associated With Patient Survival</h1> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">YOSHIATSU TANAKA</span>, <span class="highwire-citation-author" data-delta="1">SHIN-NOSUKE YAMASHITA</span>, <span class="highwire-citation-author" data-delta="2">SHAJEDUL ISLAM</span>, <span class="highwire-citation-author" data-delta="3">TAKAO KITAGAWA</span>, <span class="highwire-citation-author" data-delta="4">KAZUHIRO TOKUDA</span>, <span class="highwire-citation-author" data-delta="5">DURGA PAUDEL</span>, <span class="highwire-citation-author" data-delta="6">SARITA GIRI</span>, <span class="highwire-citation-author" data-delta="7">TOHRU OHTA</span>, <span class="highwire-citation-author" data-delta="8">FUMIYA HARADA</span>, <span class="highwire-citation-author" data-delta="9">HIROKI NAGAYASU</span> and <span class="highwire-citation-author" data-delta="10">YASUHIRO KURAMITSU</span></span></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Anticancer Research </span><span class="highwire-cite-metadata-date highwire-cite-metadata">February 2025, </span><span class="highwire-cite-metadata-volume highwire-cite-metadata">45 </span><span class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">811-815; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.21873/anticanres.17469 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/anticanres/45/2/811.atom" data-type="link" data-font-icon="" data-parent-id="83103"></span></div> </div> <div id="hw-article-author-popups-top-node-83124--61818983942" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">YOSHIATSU TANAKA </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=YOSHIATSU%2BTANAKA%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=TANAKA%20Y&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AYOSHIATSU%2BTANAKA%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">SHIN-NOSUKE YAMASHITA </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=SHIN-NOSUKE%2BYAMASHITA%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=YAMASHITA%20S&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ASHIN-NOSUKE%2BYAMASHITA%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">SHAJEDUL ISLAM </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Advanced Research Promotion Centre, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=SHAJEDUL%2BISLAM%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=ISLAM%20S&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ASHAJEDUL%2BISLAM%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this 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class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view "><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><p id="p-4">Background/Aim: Adrenocortical carcinoma is a very rare tumor characterized by poor prognosis and high mortality. The origin of this tumor is primarily the adrenal cortex. The 5-year overall survival rate of patients with adrenocortical carcinoma has not improved despite therapeutic advances. Early detection of this malignancy remains difficult, and no standard curative therapy currently exists. Therefore, it is important to understand the biology of adrenocortical carcinoma, and to identify prognostic biomarkers and molecular targets for its therapy. DDX39 is an Asp-Glu-Ala-Asp (DEAD)-box RNA helicase, which is required for transcription, splicing and transport of mRNA. There are some reports about overexpression of DDX39 in tumor tissues and cells (lung squamous cell cancer, gastrointestinal stromal tumor, urinary bladder cancer, malignant pleural mesothelioma). However, the clinicopathological involvement of DDX39 in adrenocortical carcinoma has not yet been documented. Materials and Methods: The GEPIA, GEPIA2, and UALCAN platforms were used to analyze DDX39 mRNA expression and survival in patients with adrenocortical carcinoma. Results: DDX39 was found to be significantly up-regulated in adrenocortical carcinoma tissues, and this up-regulation inversely correlated with prolonged patient survival. Conclusion: DDX39 may be a potential prognostic biomarker in patients with adrenocortical carcinoma.</p></div><span class="kwd-group-title">Key Words:</span><ul class="kwd-group"><li class="kwd"><a href="/keyword/ddx39" class="hw-term hw-article-keyword hw-article-keyword-ddx39" rel="nofollow">DDX39</a></li><li class="kwd"><a href="/keyword/adrenocortical-carcinoma" class="hw-term hw-article-keyword hw-article-keyword-adrenocortical-carcinoma" rel="nofollow">adrenocortical carcinoma</a></li><li class="kwd"><a href="/keyword/kaplan%E2%80%93meier-survival-plot" class="hw-term hw-article-keyword hw-article-keyword-kaplan–meier-survival-plot" rel="nofollow">Kaplan鈥揗eier survival plot</a></li></ul><ul class="history-list"><li xmlns:hwp="http://schema.highwire.org/Journal" class="received" hwp:start="2024-12-24"><span class="received-label">Received </span>December 24, 2024.</li><li xmlns:hwp="http://schema.highwire.org/Journal" class="rev-recd" hwp:start="2025-01-09"><span class="rev-recd-label">Revision received </span>January 9, 2025.</li><li xmlns:hwp="http://schema.highwire.org/Journal" class="accepted" hwp:start="2025-01-10"><span class="accepted-label">Accepted </span>January 10, 2025.</li></ul><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright 漏 2025 International Institute of Anticancer Research (Dr. George J. 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