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Enhanced Potential of Durvalumab in the Initial Treatment of Advanced Biliary Tract Cancer | Anticancer Research
<!DOCTYPE html> <html lang="en" dir="ltr" xmlns="http://www.w3.org/1999/xhtml" xmlns:mml="http://www.w3.org/1998/Math/MathML"> <head prefix="og: http://ogp.me/ns# article: http://ogp.me/ns/article# book: http://ogp.me/ns/book#" > <!--[if IE]><![endif]--> <link rel="dns-prefetch" href="//cdn.jsdelivr.net" /> <link rel="dns-prefetch" href="//cdn.foxycart.com" /> <link rel="dns-prefetch" href="//scholar.google.com" /> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <meta name="Generator" content="Drupal 7 (http://drupal.org)" /> <link rel="canonical" href="https://ar.iiarjournals.org/content/45/2/685" /> <link rel="alternate" type="application/pdf" title="Full Text (PDF)" href="/content/45/2/685.full.pdf" /> <link rel="alternate" type="text/plain" title="Full Text (Plain)" href="/content/45/2/685.full.txt" /> <link rel="alternate" type="application/vnd.ms-powerpoint" title="Powerpoint" href="/content/45/2/685.ppt" /> <meta name="issue_cover_image" content="https://ar.iiarjournals.org/sites/default/files/highwire/anticanres/45/2.cover-source.jpg" /> <meta name="type" content="article" /> <meta name="category" content="research-article" /> <meta name="HW.identifier" content="/anticanres/45/2/685.atom" /> <meta name="HW.pisa" content="anticanres;45/2/685" /> <meta name="DC.Format" content="text/html" /> <meta name="DC.Language" content="en" /> <meta name="DC.Title" content="Enhanced Potential of Durvalumab in the Initial Treatment of Advanced Biliary Tract Cancer" /> <meta name="DC.Identifier" content="10.21873/anticanres.17456" /> <meta name="DC.Date" content="2025-02-01" /> <meta name="DC.Publisher" content="International Institute of Anticancer Research" /> <meta name="DC.Rights" content="Copyright 漏 2025 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved." /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Description" content="Background/Aim: The prognosis of biliary tract cancer is extremely poor, with a 5-year survival rate of 20%. Surgery is the only treatment that can be expected to cure biliary tract cancer, but because many cases are unresectable or recurrent, chemotherapy has become the standard treatment. The effects of first-line administration of durvalumab have not been explored. This study examined whether durvalumab has an additive effect in the first line. Patients and Methods: Twenty-three patients who were diagnosed with recurrent or non-resected biliary tract cancer requiring anticancer chemotherapy were recruited. Three of these cases were excluded because they had only received one course of durvalumab. We retrospectively collected clinical and laboratory data. Progression-free survival (PFS) and overall survival (OS) were compared between patients who received durvalumab as first-line therapy (first group, FG) and those who received it as second-line or later therapy (second group, SG). PFS and OS were also compared in durvalumab-treated patients aged 75 years and older (older group) and in younger patients. Immune-related adverse events (irAEs) were graded using the Common Terminology Criteria for Adverse Events (CTCAE v5) based on the clinical notation available in the patient charts. Results: Kaplan鈥揗eier curves showed that SG was significantly associated with worse PFS (p=0.018), and the FG group also showed significantly prolonged OS (p=0.030). In addition, PFS from the start of durvalumab treatment was significantly longer in the older group compared to the younger group. However, no significant difference in OS was observed between the two groups. Conclusion: Durvalumab appears to contribute to prolonged PFS and OS when administered as an initial treatment. It may also contribute to improved outcomes in older patients with biliary tract cancer." /> <meta name="DC.Contributor" content="JUNGO YASUDA" /> <meta name="DC.Contributor" content="HIRONORI SHIOZAKI" /> <meta name="DC.Contributor" content="TARO SAKAMOTO" /> <meta name="DC.Contributor" content="YASURO FUTAGAWA" /> <meta name="DC.Contributor" content="TOMOYOSHI OKAMOTO" /> <meta name="DC.Contributor" content="TORU IKEGAMI" /> <meta name="article:published_time" content="2025-02-01" /> <meta name="article:section" content="Clinical Studies" /> <meta name="citation_title" content="Enhanced Potential of Durvalumab in the Initial Treatment of Advanced Biliary Tract Cancer" /> <meta name="citation_abstract" lang="en" content="<p>Background/Aim: The prognosis of biliary tract cancer is extremely poor, with a 5-year survival rate of 20%. Surgery is the only treatment that can be expected to cure biliary tract cancer, but because many cases are unresectable or recurrent, chemotherapy has become the standard treatment. The effects of first-line administration of durvalumab have not been explored. This study examined whether durvalumab has an additive effect in the first line. Patients and Methods: Twenty-three patients who were diagnosed with recurrent or non-resected biliary tract cancer requiring anticancer chemotherapy were recruited. Three of these cases were excluded because they had only received one course of durvalumab. We retrospectively collected clinical and laboratory data. Progression-free survival (PFS) and overall survival (OS) were compared between patients who received durvalumab as first-line therapy (first group, FG) and those who received it as second-line or later therapy (second group, SG). PFS and OS were also compared in durvalumab-treated patients aged 75 years and older (older group) and in younger patients. Immune-related adverse events (irAEs) were graded using the Common Terminology Criteria for Adverse Events (CTCAE v5) based on the clinical notation available in the patient charts. Results: Kaplan鈥揗eier curves showed that SG was significantly associated with worse PFS (p=0.018), and the FG group also showed significantly prolonged OS (p=0.030). In addition, PFS from the start of durvalumab treatment was significantly longer in the older group compared to the younger group. However, no significant difference in OS was observed between the two groups. Conclusion: Durvalumab appears to contribute to prolonged PFS and OS when administered as an initial treatment. It may also contribute to improved outcomes in older patients with biliary tract cancer.</p>" /> <meta name="citation_journal_title" content="Anticancer Research" /> <meta name="citation_publisher" content="International Institute of Anticancer Research" /> <meta name="citation_publication_date" content="2025/02/01" /> <meta name="citation_mjid" content="anticanres;45/2/685" /> <meta name="citation_id" content="45/2/685" /> <meta name="citation_public_url" content="https://ar.iiarjournals.org/content/45/2/685" /> <meta name="citation_abstract_html_url" content="https://ar.iiarjournals.org/content/45/2/685.abstract" /> <meta name="citation_full_html_url" content="https://ar.iiarjournals.org/content/45/2/685.full" /> <meta name="citation_pdf_url" content="https://ar.iiarjournals.org/content/anticanres/45/2/685.full.pdf" /> <meta name="citation_issn" content="0250-7005" /> <meta name="citation_issn" content="1791-7530" /> <meta name="citation_doi" content="10.21873/anticanres.17456" /> <meta name="citation_pmid" content="39890163" /> <meta name="citation_volume" content="45" /> <meta name="citation_issue" content="2" /> <meta name="citation_article_type" content="Research Article" /> <meta name="citation_section" content="Clinical Studies" /> <meta name="citation_firstpage" content="685" /> <meta name="citation_lastpage" content="690" /> <meta name="citation_author" content="JUNGO YASUDA" /> <meta name="citation_author_institution" content="Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan" /> <meta name="citation_author_email" content="j.yasuda@jikei.ac.jp" /> <meta name="citation_author" content="HIRONORI SHIOZAKI" /> <meta name="citation_author_institution" content="Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan" /> <meta name="citation_author" content="TARO SAKAMOTO" /> <meta name="citation_author_institution" content="Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan" /> <meta name="citation_author" content="YASURO FUTAGAWA" /> <meta name="citation_author_institution" content="Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan" /> <meta name="citation_author" content="TOMOYOSHI OKAMOTO" /> <meta name="citation_author_institution" content="Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan" /> <meta name="citation_author" content="TORU IKEGAMI" /> <meta name="citation_author_institution" content="Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan" /> <meta name="citation_reference" content="citation_journal_title=ESMO Open;citation_author=A. 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Califano;citation_title=Pembrolizumab plus platinum-based chemotherapy for squamous non-small cell lung cancer: the new kid on the block;citation_pages=3850-3854;citation_volume=10;citation_year=2021;citation_issue=9;citation_pmid=34733633;citation_doi=10.21037/tlcr-20-715" /> <meta name="twitter:title" content="Enhanced Potential of Durvalumab in the Initial Treatment of Advanced Biliary Tract Cancer" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:image" content="https://ar.iiarjournals.org/sites/default/files/highwire/anticanres/45/2.cover-source.jpg" /> <meta name="twitter:description" content="Background/Aim: The prognosis of biliary tract cancer is extremely poor, with a 5-year survival rate of 20%. Surgery is the only treatment that can be expected to cure biliary tract cancer, but because many cases are unresectable or recurrent, chemotherapy has become the standard treatment. The effects of first-line administration of durvalumab have not been explored. This study examined whether durvalumab has an additive effect in the first line. Patients and Methods: Twenty-three patients who were diagnosed with recurrent or non-resected biliary tract cancer requiring anticancer chemotherapy were recruited. Three of these cases were excluded because they had only received one course of durvalumab. We retrospectively collected clinical and laboratory data. Progression-free survival (PFS) and overall survival (OS) were compared between patients who received durvalumab as first-line therapy (first group, FG) and those who received it as second-line or later therapy (second group, SG). PFS and OS were also compared in durvalumab-treated patients aged 75 years and older (older group) and in younger patients. Immune-related adverse events (irAEs) were graded using the Common Terminology Criteria for Adverse Events (CTCAE v5) based on the clinical notation available in the patient charts. Results: Kaplan鈥揗eier curves showed that SG was significantly associated with worse PFS (p=0.018), and the FG group also showed significantly prolonged OS (p=0.030). In addition, PFS from the start of durvalumab treatment was significantly longer in the older group compared to the younger group. However, no significant difference in OS was observed between the two groups. Conclusion: Durvalumab appears to contribute to prolonged PFS and OS when administered as an initial treatment. It may also contribute to improved outcomes in older patients with biliary tract cancer." /> <meta name="og-title" property="og:title" content="Enhanced Potential of Durvalumab in the Initial Treatment of Advanced Biliary Tract Cancer" /> <meta name="og-url" property="og:url" content="https://ar.iiarjournals.org/content/45/2/685" /> <meta name="og-site-name" property="og:site_name" content="Anticancer Research" /> <meta name="og-description" property="og:description" content="Background/Aim: The prognosis of biliary tract cancer is extremely poor, with a 5-year survival rate of 20%. Surgery is the only treatment that can be expected to cure biliary tract cancer, but because many cases are unresectable or recurrent, chemotherapy has become the standard treatment. The effects of first-line administration of durvalumab have not been explored. This study examined whether durvalumab has an additive effect in the first line. Patients and Methods: Twenty-three patients who were diagnosed with recurrent or non-resected biliary tract cancer requiring anticancer chemotherapy were recruited. Three of these cases were excluded because they had only received one course of durvalumab. We retrospectively collected clinical and laboratory data. Progression-free survival (PFS) and overall survival (OS) were compared between patients who received durvalumab as first-line therapy (first group, FG) and those who received it as second-line or later therapy (second group, SG). PFS and OS were also compared in durvalumab-treated patients aged 75 years and older (older group) and in younger patients. Immune-related adverse events (irAEs) were graded using the Common Terminology Criteria for Adverse Events (CTCAE v5) based on the clinical notation available in the patient charts. Results: Kaplan鈥揗eier curves showed that SG was significantly associated with worse PFS (p=0.018), and the FG group also showed significantly prolonged OS (p=0.030). In addition, PFS from the start of durvalumab treatment was significantly longer in the older group compared to the younger group. However, no significant difference in OS was observed between the two groups. Conclusion: Durvalumab appears to contribute to prolonged PFS and OS when administered as an initial treatment. It may also contribute to improved outcomes in older patients with biliary tract cancer." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://ar.iiarjournals.org/sites/default/files/highwire/anticanres/45/2.cover-source.jpg" /> <link rel="shortlink" href="/node/83107" /> <link rel="shortcut icon" href="https://ar.iiarjournals.org/sites/default/files/images/favicon.ico" type="image/vnd.microsoft.icon" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <title>Enhanced Potential of Durvalumab in the Initial Treatment of Advanced Biliary Tract Cancer | Anticancer Research</title> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__QEy_BpbtMcsqv3xURK855GSs2fFjOibU10yA758Mn4c__NucWi_bEk5E3BNVDtTt2nhiPtE1A5I24YwRDQ2fojJ0__FTZ25lEcrtnzSW3JzKpn0j1z_ccWiSdhuJwjpWHa4ec.css" media="all" /> <link type="text/css" rel="stylesheet" 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class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a"> <div class="highwire-cite-overline"><span class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Clinical Studies</span></span></div> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="anticanres;45/2/685" data-atom-uri="/anticanres/45/2/685.atom" data-request-view="full"></span></div> <h1 class="highwire-cite-title" id="page-title">Enhanced Potential of Durvalumab in the Initial Treatment of Advanced Biliary Tract Cancer</h1> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">JUNGO YASUDA</span>, <span class="highwire-citation-author" data-delta="1">HIRONORI SHIOZAKI</span>, <span class="highwire-citation-author" data-delta="2">TARO SAKAMOTO</span>, <span class="highwire-citation-author" data-delta="3">YASURO FUTAGAWA</span>, <span class="highwire-citation-author" data-delta="4">TOMOYOSHI OKAMOTO</span> and <span class="highwire-citation-author" data-delta="5">TORU IKEGAMI</span></span></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Anticancer Research </span><span class="highwire-cite-metadata-date highwire-cite-metadata">February 2025, </span><span class="highwire-cite-metadata-volume highwire-cite-metadata">45 </span><span class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">685-690; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.21873/anticanres.17456 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/anticanres/45/2/685.atom" data-type="link" data-font-icon="" data-parent-id="83103"></span></div> </div> <div id="hw-article-author-popups-top-node-83107--62115331363" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">JUNGO YASUDA </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=JUNGO%2BYASUDA%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li 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class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=HIRONORI%2BSHIOZAKI%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=SHIOZAKI%20H&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AHIRONORI%2BSHIOZAKI%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">TARO SAKAMOTO </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=TARO%2BSAKAMOTO%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=SAKAMOTO%20T&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ATARO%2BSAKAMOTO%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">YASURO FUTAGAWA </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=YASURO%2BFUTAGAWA%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=FUTAGAWA%20Y&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AYASURO%2BFUTAGAWA%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">TOMOYOSHI OKAMOTO </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Department of Surgery, The Jikei University Daisan Hospital, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=TOMOYOSHI%2BOKAMOTO%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=OKAMOTO%20T&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ATOMOYOSHI%2BOKAMOTO%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">TORU IKEGAMI </div><div 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class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><p id="p-3">Background/Aim: The prognosis of biliary tract cancer is extremely poor, with a 5-year survival rate of 20%. Surgery is the only treatment that can be expected to cure biliary tract cancer, but because many cases are unresectable or recurrent, chemotherapy has become the standard treatment. The effects of first-line administration of durvalumab have not been explored. This study examined whether durvalumab has an additive effect in the first line. Patients and Methods: Twenty-three patients who were diagnosed with recurrent or non-resected biliary tract cancer requiring anticancer chemotherapy were recruited. Three of these cases were excluded because they had only received one course of durvalumab. We retrospectively collected clinical and laboratory data. Progression-free survival (PFS) and overall survival (OS) were compared between patients who received durvalumab as first-line therapy (first group, FG) and those who received it as second-line or later therapy (second group, SG). PFS and OS were also compared in durvalumab-treated patients aged 75 years and older (older group) and in younger patients. Immune-related adverse events (irAEs) were graded using the Common Terminology Criteria for Adverse Events (CTCAE v5) based on the clinical notation available in the patient charts. Results: Kaplan鈥揗eier curves showed that SG was significantly associated with worse PFS (p=0.018), and the FG group also showed significantly prolonged OS (p=0.030). In addition, PFS from the start of durvalumab treatment was significantly longer in the older group compared to the younger group. However, no significant difference in OS was observed between the two groups. Conclusion: Durvalumab appears to contribute to prolonged PFS and OS when administered as an initial treatment. It may also contribute to improved outcomes in older patients with biliary tract cancer.</p></div><span class="kwd-group-title">Key Words:</span><ul class="kwd-group"><li class="kwd"><a href="/keyword/durvalumab" class="hw-term hw-article-keyword hw-article-keyword-durvalumab" rel="nofollow">Durvalumab</a></li><li class="kwd"><a href="/keyword/advanced-biliary-tract-cancer" class="hw-term hw-article-keyword hw-article-keyword-advanced-biliary-tract-cancer" rel="nofollow">advanced biliary tract cancer</a></li><li class="kwd"><a href="/keyword/old-age" class="hw-term hw-article-keyword hw-article-keyword-old-age" rel="nofollow">old age</a></li></ul><ul class="history-list"><li xmlns:hwp="http://schema.highwire.org/Journal" class="received" hwp:start="2024-12-30"><span class="received-label">Received </span>December 30, 2024.</li><li xmlns:hwp="http://schema.highwire.org/Journal" class="rev-recd" hwp:start="2025-01-16"><span class="rev-recd-label">Revision received </span>January 16, 2025.</li><li xmlns:hwp="http://schema.highwire.org/Journal" class="accepted" hwp:start="2025-01-20"><span class="accepted-label">Accepted </span>January 20, 2025.</li></ul><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright 漏 2025 International Institute of Anticancer Research (Dr. George J. 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