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LV Packaging and Producer Cell Lines - OXGENE

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nav_cart_antibody_dscovery" href='/cell_therapy/plasmids_cell_lines.aspx'>Plasmids &amp; Cell Lines</a></li><li class=" li_nav_aav_capsid_dscovery"><a class=" nav_aav_capsid_dscovery" href='/cell_therapy/transient_lv_production_systems.aspx'>Transient LV Production Systems</a></li><li class=" li_nav_lv_packaging_and_producer_cell_lines"><a class=" nav_lv_packaging_and_producer_cell_lines" href='/cell_therapy/lv_packaging_and_producer_cell_lines.aspx'>LV Packaging and Producer Cell Lines</a></li></ul> <!--Editable Text--> <h1>LV PACKAGING AND <strong>PRODUCER CELL LINES</strong></h1> <p class="lg_p">Our Lenti viral vector stable clonal packaging and producer cell lines offer easy scale up, reduced cost of goods and reduced process complexity. Lenti viral vector packaging and producer cell lines contain the same proven genetic system as the Lenti viral vector transient system, facilitating a smooth transition to this more scalable technology, and retaining all the optimisation benefits developed for the transient system.</p> <!--/Editable Text--> </div> <div class="container-fluid"> <!--Editable Text--> <section class="img_divider_widget"> <div class="img_divider_image"> <div class="container"> <p><img src="/_userfiles/pages/images/cell_therapy/oxford_genetics_rgr_020.jpg" style="width: 60%; height: 60%;" /></p> </div> </div> <div class="img_divider_content"> <div class="container"> <h2 class="alternative">"OXGENE's Lenti viral vector packaging and producer cell lines offer a cost-effective solution for large scale cell therapy manufacture"</h2> </div> </div> </section> <section class="paragraph_widget"> <div class="container"> <h3 class="lg_p">Lenti viral vector packaging cell lines</h3> <p class="lg_p">OXGENE has successfully developed a suspension-mode, stable lentiviral packaging cell line platform using a proprietary Tet-inducible system. This demonstrates high titre lentiviral production with single plasmid transfection in both shake flask and bioreactor.</p> <p class="lg_p">Our packaging cell lines, containing inducible VSV-G, Gag-Pol and Rev, have been developed with full traceability from a GMP banked cell line, and provide a simple, flexible platform from which to test multiple transgenes, or variants of a transgene, for further development.</p> <p class="lg_p">We use a fully defined, serum/animal component free process to generate both our packaging and producer GMP-compliant HEK293 cell lines, which do not contain the SV40 Large-T antigen and remain stable in the absence of antibiotic selection, minimising the regulatory risks in transitioning to clinical use.</p> </div> </section> <div class="editable_expandable spacer"> <div aria-expanded="true" class="expandable_heading" data-target="#panel535" data-toggle="collapse"> <h4 class="expandable_title">Lenti viral vector packaging cell line achieves titres up to 4E7 TU/mL</h4> </div> <div aria-expanded="true" class="expandable_collapse collapse in" id="panel535" style=""> <div class="expandable_body"> <p><img alt="" src="/_userfiles/pages/images/cell_therapy/lentititre01_1080x839.png" style="width: 100%;" /></p> <p>OXGENE's Lenti viral vector packaging cell line uses only one plasmid and assures reduced inter-batch variability in transfection efficiency compared to the transient system. The Lenti viral vector packaging cell line achieves titres of up to 4E7 TU/mL, compared to the transient system's 8E7 TU/mL.</p> </div> </div> <div class="clearer"> </div> </div> <section class="paragraph_widget"> <div class="container"> <h3>Lenti viral vector producer cell lines</h3> <p class="lg_p">Our packaging cell lines also form the basis of our animal component free custom producer cell lines, derived from a GMP banked master cell line using our automated platform to screen thousands of single cell clones. These permit transfection-free, large-scale production of lentiviral vectors for cell or gene therapies. This reduces the overall cost of goods and process complexity involved in clinical-scale viral vector production, while improving scalability and system reproducibility.</p> <p class="lg_p">A further advantage of producer cell lines is the added potential for process development to improve viral titres once we've stably integrated your gene of interest, free from the process limitations imposed by transfection. Overall, lentiviral producer cell lines allow the consistent production of large quantities of lentiviral vector at lower cost.</p> <p class="lg_p">OXGENE’s producer cell lines use our proprietary Lenti viral vector genetic system, which is optimised for translation efficiency, has Tet inducible VSV-G and Gag-Pol expression, and low homology between expression cassettes for an improved safety profile.</p> <p class="lg_p">We use a fully defined, serum/animal component free process to generate both our packaging and producer GMP-compliant HEK293 cell lines. Cell lines do not contain the SV40 Large-T antigen and remain stable in the absence of antibiotic selection, minimising the regulatory risks in transitioning to clinical use.</p> </div> </section> <section class="divider_widget orange"> <div class="container"> <div class="left_col"> <h2 class="alternative">Talk to us about Lenti viral vector Packaging<br /> or Producer Cell Lines</h2> </div> <div class="right_col"> <p style="text-align: right;"><a class="orange_btn" href="/about/contact/business_development_enquiry.aspx">GET IN TOUCH</a></p> </div> </div> </section> <p> </p> <section class="divider_widget grey"> <div class="container"> <div class="left_col"> <h2 class="alternative">Are you ready for GMP Manufacture?</h2> <p>WuXi Advanced Therapies is a global Contract Testing, Development<br /> and Manufacturing Organization (CTDMO) dedicated to accelerating<br /> progress and time to market for cell and gene therapies.</p> </div> <div class="right_col"> <p style="text-align: right;"><a class="orange_btn" href="/gmp_manufacture_testing.aspx">GMP MANUFACTURE</a></p> </div> </div> </section> <!--/Editable Text--> </div> </article> </section> <footer id="footer"> <div class="hd_container container"> <div class="row"> <div class="col-xs-12"> <div class="footer_logo"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" id="Layer_1" x="0px" y="0px" viewBox="0 0 617 139.9" style="enable-background:new 0 0 617 139.9;" xml:space="preserve"> <style type="text/css"> .footer_logo .st0{fill:#ffffff;} </style> <g> <path class="st0" d="M254.5,54h23.3v19c-3,2.2-6.3,3.9-9.8,5.1c-3.9,1.3-8,1.9-12.2,1.9c-4.4,0.1-8.7-0.8-12.7-2.5 c-7.5-3.2-13.3-9.4-16.1-17.1c-1.5-4.2-2.3-8.6-2.2-13.1V47c0-4.2,0.8-8.5,2.3-12.4c1.4-3.8,3.6-7.3,6.3-10.2 c2.6-2.9,5.8-5.3,9.4-7c3.6-1.7,7.6-2.6,11.7-2.6c2.6,0,5.3,0.2,7.9,0.7c2.3,0.5,4.5,1.1,6.6,2c2,0.8,3.9,1.9,5.7,3.1 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Please complete this form as it will help us understand who is interested in our resource materials.</p> <div class="row" onkeypress="javascript:return WebForm_FireDefaultButton(event, &#39;ctl25_ButtonLeadSubmit&#39;)"> <div class="form-group col-xs-12 col-sm-6"> <label class="control-label" for="ctl25_TBFirstName">*First Name</label> <input name="ctl00$ctl00$ctl00$ctl25$TBFirstName" type="text" id="ctl25_TBFirstName" class="form-control" /> <span id="ctl25_RFVFirstName" class="validationError" style="display:none;"><span class='glyphicon glyphicon-remove form-control-feedback'></span><span class='help-block'>First name required</span></span> </div> <div class="clearfix visible-xs"></div> <div class="form-group col-xs-12 col-sm-6"> <label class="control-label" for="ctl25_TBLastName">*Last Name</label> <input name="ctl00$ctl00$ctl00$ctl25$TBLastName" type="text" id="ctl25_TBLastName" class="form-control" /> <span id="ctl25_RFVLastName" class="validationError" style="display:none;"><span class='glyphicon glyphicon-remove form-control-feedback'></span><span class='help-block'>Last name required</span></span> </div> <div class="clearfix"></div> <div class="form-group col-xs-12"> <label class="control-label" for="ctl25_TBCompany">*Company</label> <input name="ctl00$ctl00$ctl00$ctl25$TBCompany" type="text" id="ctl25_TBCompany" class="form-control" /> <span id="ctl25_RFVCompany" class="validationError" style="display:none;"><span class='glyphicon glyphicon-remove form-control-feedback'></span><span class='help-block'>Company name required</span></span> </div> <div class="clearfix"></div> <div class="form-group col-xs-12"> <label class="control-label" for="ctl25_TBEmail">*Email</label> <input name="ctl00$ctl00$ctl00$ctl25$TBEmail" type="text" id="ctl25_TBEmail" class="form-control" /> <span id="ctl25_RFVEmail" class="validationError" style="display:none;"><span class='glyphicon glyphicon-remove form-control-feedback'></span><span class='help-block'>Email required</span></span> <span id="ctl25_REVEmail" style="display:none;"><span class='help-block'>Invalid email address</span></span> </div> <div class="clearfix"></div> <div class="form-group col-xs-12 col-sm-6"> <label class="control-label" for="ctl25_DDLLocation">*Location</label> <select name="ctl00$ctl00$ctl00$ctl25$DDLLocation" id="ctl25_DDLLocation" class="form-control"> <option value="">- Select -</option> <option value="Asia">Asia</option> <option value="Europe">Europe</option> <option value="USA">USA</option> <option value="UK">UK</option> <option value="Other">Other</option> </select> <span id="ctl25_RFVLocation" class="validationError" style="display:none;"><span class='glyphicon glyphicon-remove form-control-feedback'></span><span class='help-block'>Location required</span></span> </div> <div class="clearfix visible-xs"></div> <div class="form-group col-xs-12 col-sm-6"> <label class="control-label" for="ctl25_DDLOrganisation">Organisation Type</label> <select name="ctl00$ctl00$ctl00$ctl25$DDLOrganisation" id="ctl25_DDLOrganisation" class="form-control"> <option value="">- Select -</option> <option value="Academic">Academic</option> <option value="Biotech / Pharma">Biotech / Pharma</option> <option value="Hospital">Hospital</option> <option value="Not for profit">Not for profit</option> <option value="Other">Other</option> </select> </div> <div class="clearfix"></div> <div class="form-group col-xs-12 spacer_top"> <div style="display: none;"> <input type="text" id="PreventChromeAutocomplete" name="PreventChromeAutocomplete" autocomplete="address-level4" /> </div> <div class="hon3yp0t"> <label for="ctl25_ctl01_TBEmal" style="display: block;">Please only enter your email here if you are not a real person.</label><input name="ctl00$ctl00$ctl00$ctl25$ctl01$TBEmal" type="text" id="ctl25_ctl01_TBEmal" autocomplete="off" style="display: block;" /> </div> <input id="ctl25_ctl01_CBBot" type="checkbox" name="ctl00$ctl00$ctl00$ctl25$ctl01$CBBot" checked="checked" /><label for="ctl25_ctl01_CBBot">When you're ready to send the form, uncheck this box and continue. This helps keep our forms secure.</label> &nbsp;<span id="ctl25_ctl01_BotCheckBoxValidator" class="validationError" style="visibility:hidden;">Please uncheck this box to continue</span> <script type="text/javascript"> function validateCheckboxctl25_ctl01_CBBot(sender, arguments) { arguments.IsValid = !document.getElementById("ctl25_ctl01_CBBot").checked; } </script> <br /> <input type="hidden" name="ctl00$ctl00$ctl00$ctl25$ctl01$HiddenTimestamp" id="ctl25_ctl01_HiddenTimestamp" value="638682988216836765" /> <input type="hidden" name="ctl00$ctl00$ctl00$ctl25$ctl01$HiddenSpinner" id="ctl25_ctl01_HiddenSpinner" value="32200379f22382a89df9ee712ab34eed" /> <span id="ctl25_ctl01_BotValidator" style="visibility:hidden;"></span> </div> <div class="clearfix"></div> <div class="form-group col-xs-12"> <p style="margin: 0; font-size: 0.9em; line-height: 1.4em;">Please view our <a href="../privacy_policy.aspx" target="_blank">Privacy Policy here</a>. 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They will ask you about your future contact preferences.</p> </div> <div class="clearfix"></div> <div class="form-group col-xs-12 spacer_top"> <input type="submit" name="ctl00$ctl00$ctl00$ctl25$ButtonLeadSubmit" value="SUBMIT" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$ctl00$ctl00$ctl25$ButtonLeadSubmit&quot;, &quot;&quot;, true, &quot;leads&quot;, &quot;&quot;, false, false))" id="ctl25_ButtonLeadSubmit" class="orange_btn" /> </div> </div><input type="hidden" name="ctl00$ctl00$ctl00$ctl25$HFResourceID" id="ctl25_HFResourceID" /> </div> </div> </div> </div> <div class="modal_container"></div> <script type="text/javascript"> extraJQueryFunctions.push(function ($) { $('a.lead_capture_btn').on('click', function () { $('#ctl25_HFResourceID').val($(this).attr('data-resource')); }); $('.modal_btn').on('click', function () { var id = $(this).attr('data-resource'); renderVideoModal(id, "/modules/ModuleResources/_resources/json/video_modal.aspx"); }); }); </script> <script type="text/javascript" src="https://ajax.googleapis.com/ajax/libs/jquery/2.2.4/jquery.min.js"></script> <script type="text/javascript"> if (typeof jQuery == 'undefined') {document.write(unescape("%3Cscript src='/_resources/js/jquery-2.2.4.min.js' type='text/javascript'%3E%3C/script%3E"));} </script> <script type="text/javascript"> //<![CDATA[ var Page_Validators = new Array(document.getElementById("ctl25_RFVFirstName"), document.getElementById("ctl25_RFVLastName"), document.getElementById("ctl25_RFVCompany"), document.getElementById("ctl25_RFVEmail"), document.getElementById("ctl25_REVEmail"), document.getElementById("ctl25_RFVLocation"), document.getElementById("ctl25_ctl01_BotCheckBoxValidator"), document.getElementById("ctl25_ctl01_BotValidator")); //]]> </script> <script type="text/javascript"> //<![CDATA[ var ctl25_RFVFirstName = document.all ? document.all["ctl25_RFVFirstName"] : document.getElementById("ctl25_RFVFirstName"); ctl25_RFVFirstName.controltovalidate = "ctl25_TBFirstName"; ctl25_RFVFirstName.errormessage = "Please enter your first name"; ctl25_RFVFirstName.display = "Dynamic"; ctl25_RFVFirstName.validationGroup = "leads"; ctl25_RFVFirstName.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVFirstName.initialvalue = ""; var ctl25_RFVLastName = document.all ? document.all["ctl25_RFVLastName"] : document.getElementById("ctl25_RFVLastName"); ctl25_RFVLastName.controltovalidate = "ctl25_TBLastName"; ctl25_RFVLastName.errormessage = "Please enter your last name"; ctl25_RFVLastName.display = "Dynamic"; ctl25_RFVLastName.validationGroup = "leads"; ctl25_RFVLastName.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVLastName.initialvalue = ""; var ctl25_RFVCompany = document.all ? document.all["ctl25_RFVCompany"] : document.getElementById("ctl25_RFVCompany"); ctl25_RFVCompany.controltovalidate = "ctl25_TBCompany"; ctl25_RFVCompany.errormessage = "Please enter your company name"; ctl25_RFVCompany.display = "Dynamic"; ctl25_RFVCompany.validationGroup = "leads"; ctl25_RFVCompany.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVCompany.initialvalue = ""; var ctl25_RFVEmail = document.all ? document.all["ctl25_RFVEmail"] : document.getElementById("ctl25_RFVEmail"); ctl25_RFVEmail.controltovalidate = "ctl25_TBEmail"; ctl25_RFVEmail.errormessage = "Please enter your email address"; ctl25_RFVEmail.display = "Dynamic"; ctl25_RFVEmail.validationGroup = "leads"; ctl25_RFVEmail.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVEmail.initialvalue = ""; var ctl25_REVEmail = document.all ? document.all["ctl25_REVEmail"] : document.getElementById("ctl25_REVEmail"); ctl25_REVEmail.controltovalidate = "ctl25_TBEmail"; ctl25_REVEmail.errormessage = "<span class=\'help-block\'>Invalid email address</span>"; ctl25_REVEmail.display = "Dynamic"; ctl25_REVEmail.validationGroup = "leads"; ctl25_REVEmail.evaluationfunction = "RegularExpressionValidatorEvaluateIsValid"; ctl25_REVEmail.validationexpression = "^\\w+([-+.\']\\w+)*@\\w+([-.]\\w+)*\\.\\w+([-.]\\w+)*$"; var ctl25_RFVLocation = document.all ? document.all["ctl25_RFVLocation"] : document.getElementById("ctl25_RFVLocation"); ctl25_RFVLocation.controltovalidate = "ctl25_DDLLocation"; ctl25_RFVLocation.errormessage = "Please select your location"; ctl25_RFVLocation.display = "Dynamic"; ctl25_RFVLocation.validationGroup = "leads"; ctl25_RFVLocation.evaluationfunction = "RequiredFieldValidatorEvaluateIsValid"; ctl25_RFVLocation.initialvalue = ""; var ctl25_ctl01_BotCheckBoxValidator = document.all ? document.all["ctl25_ctl01_BotCheckBoxValidator"] : document.getElementById("ctl25_ctl01_BotCheckBoxValidator"); ctl25_ctl01_BotCheckBoxValidator.errormessage = "Please uncheck this box to continue"; ctl25_ctl01_BotCheckBoxValidator.validationGroup = "leads"; ctl25_ctl01_BotCheckBoxValidator.evaluationfunction = "CustomValidatorEvaluateIsValid"; ctl25_ctl01_BotCheckBoxValidator.clientvalidationfunction = "validateCheckboxctl25_ctl01_CBBot"; var ctl25_ctl01_BotValidator = document.all ? document.all["ctl25_ctl01_BotValidator"] : document.getElementById("ctl25_ctl01_BotValidator"); ctl25_ctl01_BotValidator.validationGroup = "leads"; ctl25_ctl01_BotValidator.evaluationfunction = "CustomValidatorEvaluateIsValid"; //]]> </script> <script type="text/javascript"> //<![CDATA[ var Page_ValidationActive = false; if (typeof(ValidatorOnLoad) == "function") { ValidatorOnLoad(); } function ValidatorOnSubmit() { if (Page_ValidationActive) { return ValidatorCommonOnSubmit(); } else { return true; } } //]]> </script> </form> <script src="/_resources/js/master/master.min.v20220920171055.js" type="text/javascript"></script> <script src="/_resources/js/include_masterpage.min.v20210903123328.js" type="text/javascript"></script> <!-- The Bootstrap Image Gallery lightbox, should be a child element of the document body --> <div id="blueimp-gallery" class="blueimp-gallery"> <!-- The container for the modal slides --> <div class="slides"></div> <!-- Controls for the borderless lightbox --> <h3 class="title"></h3> <a class="prev">‹</a> <a class="next">›</a> <a class="close">×</a> <a class="play-pause"></a> <ol class="indicator"></ol> <!-- The modal dialog, which will be used to wrap the lightbox content --> <div class="modal fade"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" aria-hidden="true">&times;</button> <h4 class="modal-title"></h4> </div> <div class="modal-body next"></div> <div class="modal-footer"> <button type="button" class="btn btn-default pull-left prev"> <i class="glyphicon glyphicon-chevron-left"></i> Previous </button> <button type="button" class="btn btn-primary next"> Next <i class="glyphicon glyphicon-chevron-right"></i> </button> </div> </div> </div> </div> </div> </body> </html>

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