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Irvine Page - Wikipedia

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<div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox biography vcard"><tbody><tr><th colspan="2" class="infobox-above" style="font-size:125%;"><div class="fn">Irvine Page</div></th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Dr._Irvine_Page_and_Lab_Tech_1960s_A3112.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Dr._Irvine_Page_and_Lab_Tech_1960s_A3112.jpg/220px-Dr._Irvine_Page_and_Lab_Tech_1960s_A3112.jpg" decoding="async" width="220" height="156" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Dr._Irvine_Page_and_Lab_Tech_1960s_A3112.jpg/330px-Dr._Irvine_Page_and_Lab_Tech_1960s_A3112.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Dr._Irvine_Page_and_Lab_Tech_1960s_A3112.jpg/440px-Dr._Irvine_Page_and_Lab_Tech_1960s_A3112.jpg 2x" data-file-width="3000" data-file-height="2132" /></a></span><div class="infobox-caption">Page (right) and lab tech in the 1960s</div></td></tr><tr><th scope="row" class="infobox-label">Born</th><td class="infobox-data"><div style="display:inline" class="nickname">Irvine Heinly Page</div><br /><span style="display:none">(<span class="bday">1901-01-07</span>)</span>January 7, 1901<br /><div style="display:inline" class="birthplace"><a href="/wiki/Indianapolis" title="Indianapolis">Indianapolis</a>, <a href="/wiki/Indiana" title="Indiana">Indiana</a>, US</div></td></tr><tr><th scope="row" class="infobox-label">Died</th><td class="infobox-data">June 10, 1991<span style="display:none">(1991-06-10)</span> (aged&#160;90)<br /><div style="display:inline" class="deathplace"><a href="/wiki/Hyannis_Port,_Massachusetts" title="Hyannis Port, Massachusetts">Hyannis Port</a>, <a href="/wiki/Massachusetts" title="Massachusetts">Massachusetts</a>, US</div></td></tr></tbody></table> <p><b>Irvine Heinly Page</b> (January 7, 1901 – June 10, 1991) was an American <a href="/wiki/Physiology" title="Physiology">physiologist</a> who played an important part in the field of <a href="/wiki/Hypertension" title="Hypertension">hypertension</a> for almost 60 years while working at the <a href="/wiki/Cleveland_Clinic" title="Cleveland Clinic">Cleveland Clinic</a> as the first Chair of Research.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-dustan1991_3-0" class="reference"><a href="#cite_note-dustan1991-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Early_life_and_education">Early life and education</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Irvine_Page&amp;action=edit&amp;section=1" title="Edit section: Early life and education"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Irvine Page was born on January 7, 1901, in Indianapolis, Indiana. He attended college at <a href="/wiki/Cornell_University" title="Cornell University">Cornell University</a>, with an undergraduate degree in chemistry (1921) and an M.D. degree in 1926.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> Page completed his internship at <a href="/wiki/Presbyterian_Hospital_(New_York_City)" title="Presbyterian Hospital (New York City)">Presbyterian</a> and <a href="/wiki/Bellevue_Hospital" title="Bellevue Hospital">Bellevue Hospitals</a> in New York City.<sup id="cite_ref-gifford1987_5-0" class="reference"><a href="#cite_note-gifford1987-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Career">Career</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Irvine_Page&amp;action=edit&amp;section=2" title="Edit section: Career"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>After completing his internship, Page then performed research in <a href="/wiki/Physical_chemistry" title="Physical chemistry">physical chemistry</a> at Woods Hole and then New York. In 1928 he joined the <a href="/wiki/Kaiser_Wilhelm_Society" title="Kaiser Wilhelm Society">Kaiser Wilhelm Institute</a> in <a href="/wiki/Munich" title="Munich">Munich</a>, <a href="/wiki/Germany" title="Germany">Germany</a> where he started a new department of <a href="/wiki/Neurochemistry" title="Neurochemistry">neurochemistry</a>. With the coming rise to power of <a href="/wiki/Hitler" class="mw-redirect" title="Hitler">Hitler</a>, Page left Munich in 1931 to work with <a href="/wiki/Donald_Van_Slyke" title="Donald Van Slyke">Donald Van Slyke</a> at <a href="/wiki/Rockefeller_University" title="Rockefeller University">The Rockefeller Institute for Medical Research</a> in New York City. He worked at the Rockefeller Institute through 1937. Page then moved back to Indianapolis as Director of the Laboratory for Clinical Research at <a href="/wiki/Eli_Lilly_and_Company" title="Eli Lilly and Company">Eli Lilly</a> at <a href="/wiki/Sidney_%26_Lois_Eskenazi_Hospital" title="Sidney &amp; Lois Eskenazi Hospital">City Hospital</a>. In 1945, Page then organized a new research division at the <a href="/wiki/Cleveland_Clinic" title="Cleveland Clinic">Cleveland Clinic</a>.<sup id="cite_ref-gifford1987_5-1" class="reference"><a href="#cite_note-gifford1987-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> </p><p>His first contributions were published in the early 1930s and his most recent, "Hypertension Research: A Memoir: 1920–1960", in 1988. He is perhaps best known for the co-discovery of <a href="/wiki/Serotonin" title="Serotonin">serotonin</a> in 1948,<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> although his pre-eminence is a matter of record in four other areas: the <a href="/wiki/Renin%E2%80%93angiotensin_system" title="Renin–angiotensin system">renin–angiotensin system</a>, the mosaic theory of hypertension,<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> treatment of hypertension and public and professional <a href="/wiki/Advocacy" title="Advocacy">advocacy</a> of the recognition of this condition and its effects in daily life. In earlier work he published on the <a href="/wiki/Neurochemistry" title="Neurochemistry">neurochemistry</a> of the <a href="/wiki/Brain" title="Brain">brain</a>. </p><p>Page received many honors for his work. He was on the cover of Time magazine in 1955.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup> He was president of the <a href="/wiki/American_Heart_Association" title="American Heart Association">American Heart Association</a> (1956–57); he received ten <a href="/wiki/Honorary_degrees" class="mw-redirect" title="Honorary degrees">honorary degrees</a> and a number of prestigious awards—the Ida B. Gould Memorial Award of the <a href="/wiki/American_Association_for_the_Advancement_of_Science" title="American Association for the Advancement of Science">American Association for the Advancement of Science</a> (1957); Albert <a href="/wiki/Lasker_Award" title="Lasker Award">Lasker Award</a> (1958); <a href="/wiki/Gairdner_Foundation_International_Award" class="mw-redirect" title="Gairdner Foundation International Award">Gairdner Foundation International Award</a> (1963); Distinguished Award of the <a href="/wiki/American_Medical_Association" title="American Medical Association">American Medical Association</a> (1964); <a href="/w/index.php?title=Oscar_B._Hunter_Award&amp;action=edit&amp;redlink=1" class="new" title="Oscar B. Hunter Award (page does not exist)">Oscar B. Hunter Award</a> (1966); Golden Plate Award of the <a href="/wiki/Academy_of_Achievement" title="Academy of Achievement">American Academy of Achievement</a> (1966);<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Passano_Foundation" title="Passano Foundation">Passano Foundation</a> Award (1967); and the Stouffer Prize (now the <a href="/wiki/Novartis" title="Novartis">Novartis</a> Award) for Hypertension Research in 1970. He was elected to the <a href="/wiki/United_States_National_Academy_of_Sciences" class="mw-redirect" title="United States National Academy of Sciences">National Academy of Sciences</a> in 1971 and published his memoirs in 1988. </p><p>The American Heart Association <a rel="nofollow" class="external text" href="http://www.heart.org/presenter.jhtml?identifier=3041097">Irvine H. Page Young Investigator Research Award</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20070927024409/http://www.heart.org/presenter.jhtml?identifier=3041097">Archived</a> 2007-09-27 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a> and the <a rel="nofollow" class="external text" href="http://www.americanheart.org/presenter.jhtml?identifier=491">Irvine Page – Alva Bradley Lifetime Achievement Award</a> are named in his honor. </p> <div class="mw-heading mw-heading2"><h2 id="Later_life">Later life</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Irvine_Page&amp;action=edit&amp;section=3" title="Edit section: Later life"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A collection of his papers is held at the National Library of Medicine in Bethesda, Maryland.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Personal_life">Personal life</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Irvine_Page&amp;action=edit&amp;section=4" title="Edit section: Personal life"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>He was married to Beatrice Allen, a dancer, poet, and author of the book, The Bracelet. His sister was <a href="/wiki/Ruth_Page_(ballerina)" title="Ruth Page (ballerina)">Ruth Page</a>, a noted American ballet dancer. Page was also a gifted musician, a trait he passed on to his two sons, Christopher Page and Nicholas Page. Page lived in Cleveland, OH with his wife and children, summering in Hyannis Port on Cape Cod. His family home on the Cape is now owned and occupied by his granddaughter and great-grandchildren. </p> <div class="mw-heading mw-heading3"><h3 id="Death">Death</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Irvine_Page&amp;action=edit&amp;section=5" title="Edit section: Death"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Having retired to Hyannis Port, Massachusetts, Page died suddenly on June 10, 1991, at the age of 90. He had been previously injured in an auto accident in March 1990 and suffered from poor health due to a prior stroke and a prior heart attack.<sup id="cite_ref-dustan1991_3-1" class="reference"><a href="#cite_note-dustan1991-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Selected_publications">Selected publications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Irvine_Page&amp;action=edit&amp;section=6" title="Edit section: Selected publications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFPage1987" class="citation book cs1">Page, Irvine (1987). <i>Hypertension Mechanisms</i>. Orlando, Fla.: Grune &amp; Stratton. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0-8089-1768-7" title="Special:BookSources/978-0-8089-1768-7"><bdi>978-0-8089-1768-7</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Hypertension+Mechanisms&amp;rft.place=Orlando%2C+Fla.&amp;rft.pub=Grune+%26+Stratton&amp;rft.date=1987&amp;rft.isbn=978-0-8089-1768-7&amp;rft.aulast=Page&amp;rft.aufirst=Irvine&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPage1988" class="citation book cs1">Page, Irvine (1988). <i>Hypertension Research: A Memoir&#160;: 1920-1960</i>. New York: Pergamon. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0-08-036079-9" title="Special:BookSources/978-0-08-036079-9"><bdi>978-0-08-036079-9</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Hypertension+Research%3A+A+Memoir+%3A+1920-1960&amp;rft.place=New+York&amp;rft.pub=Pergamon&amp;rft.date=1988&amp;rft.isbn=978-0-08-036079-9&amp;rft.aulast=Page&amp;rft.aufirst=Irvine&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPage1937" class="citation book cs1">Page, Irvine (1937). <i>Chemistry of the brain</i>. New York: C.C. Thomas. ASIN B-000-87D23-C.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Chemistry+of+the+brain&amp;rft.place=New+York&amp;rft.pub=C.C.+Thomas&amp;rft.date=1937&amp;rft.aulast=Page&amp;rft.aufirst=Irvine&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></li> <li>Page, Irvine (1972). <i>Speaking to the Doctor: His Responsibilities and Opportunities: Selected Editorials from Modern Medicine</i>. Minneapolis: Proforum.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Footnotes">Footnotes</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Irvine_Page&amp;action=edit&amp;section=7" title="Edit section: Footnotes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDustan1990" class="citation journal cs1"><a href="/wiki/Harriet_P._Dustan" title="Harriet P. Dustan">Dustan, HP</a> (1990). "Irvine Page lecture. Legacies of Irvine H. Page". <i>Journal of Hypertension Supplement</i>. <b>8</b> (7): S29–34. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2095393">2095393</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Journal+of+Hypertension+Supplement&amp;rft.atitle=Irvine+Page+lecture.+Legacies+of+Irvine+H.+Page.&amp;rft.volume=8&amp;rft.issue=7&amp;rft.pages=S29-34&amp;rft.date=1990&amp;rft_id=info%3Apmid%2F2095393&amp;rft.aulast=Dustan&amp;rft.aufirst=HP&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text">Dustan HP <i><a rel="nofollow" class="external text" href="http://books.nap.edu/readingroom/books/biomems/ipage.pdf">Irvine Heinly Page.</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20110607044600/http://books.nap.edu/readingroom/books/biomems/ipage.pdf">Archived</a> 2011-06-07 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a></i> The National Academies Press Biographical Memoirs.</span> </li> <li id="cite_note-dustan1991-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-dustan1991_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-dustan1991_3-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Frohlich ED, <a href="/wiki/Harriet_P._Dustan" title="Harriet P. Dustan">Dustan HP</a>, Bumpus FM <i><a rel="nofollow" class="external text" href="http://hyper.ahajournals.org/cgi/reprint/18/4/443.pdf">Irvine H. Page: 1901-1991. The Celebration of a Leader</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200411210403/https://www.ahajournals.org/action/cookieAbsent">Archived</a> 2020-04-11 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a></i> Hypertension 1991;18:443–445.</span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://news.weill.cornell.edu/sites/default/files/publications/wcm_vol15_no3.pdf">"weill cornell medicine"</a> <span class="cs1-format">(PDF)</span>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220616040519/https://news.weill.cornell.edu/sites/default/files/publications/wcm_vol15_no3.pdf">Archived</a> <span class="cs1-format">(PDF)</span> from the original on 16 June 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">6 July</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=weill+cornell+medicine&amp;rft_id=https%3A%2F%2Fnews.weill.cornell.edu%2Fsites%2Fdefault%2Ffiles%2Fpublications%2Fwcm_vol15_no3.pdf&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></span> </li> <li id="cite_note-gifford1987-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-gifford1987_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-gifford1987_5-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGifford1987" class="citation journal cs1">Gifford, R. (January 1987). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fclc.4960100117">"Profiles in cardiology: Irvine h. page"</a>. <i>Clinical Cardiology</i>. <b>10</b> (1): 68–69. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fclc.4960100117">10.1002/clc.4960100117</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3545576">3545576</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Clinical+Cardiology&amp;rft.atitle=Profiles+in+cardiology%3A+Irvine+h.+page&amp;rft.volume=10&amp;rft.issue=1&amp;rft.pages=68-69&amp;rft.date=1987-01&amp;rft_id=info%3Adoi%2F10.1002%2Fclc.4960100117&amp;rft_id=info%3Apmid%2F3545576&amp;rft.aulast=Gifford&amp;rft.aufirst=R.&amp;rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252Fclc.4960100117&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRapportGreenPage1948" class="citation journal cs1">Rapport, MM; Green, AA; Page, IH (1948). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2957137-4">"Serum vasoconstrictor (serotonin). IV. Isolation and characterization"</a>. <i>J Biol Chem</i>. <b>176</b> (3): 1243–1251. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2957137-4">10.1016/S0021-9258(18)57137-4</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18100415">18100415</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=J+Biol+Chem&amp;rft.atitle=Serum+vasoconstrictor+%28serotonin%29.+IV.+Isolation+and+characterization&amp;rft.volume=176&amp;rft.issue=3&amp;rft.pages=1243-1251&amp;rft.date=1948&amp;rft_id=info%3Adoi%2F10.1016%2FS0021-9258%2818%2957137-4&amp;rft_id=info%3Apmid%2F18100415&amp;rft.aulast=Rapport&amp;rft.aufirst=MM&amp;rft.au=Green%2C+AA&amp;rft.au=Page%2C+IH&amp;rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0021-9258%252818%252957137-4&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPage1967" class="citation journal cs1">Page, IH (1967). "The mosaic theory of arterial hypertension--its interpretation". <i>Perspectives in Biology and Medicine</i>. <b>10</b> (3): 325–33. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1353%2Fpbm.1967.0031">10.1353/pbm.1967.0031</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/6034593">6034593</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a>&#160;<a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:29576640">29576640</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Perspectives+in+Biology+and+Medicine&amp;rft.atitle=The+mosaic+theory+of+arterial+hypertension--its+interpretation.&amp;rft.volume=10&amp;rft.issue=3&amp;rft.pages=325-33&amp;rft.date=1967&amp;rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A29576640%23id-name%3DS2CID&amp;rft_id=info%3Apmid%2F6034593&amp;rft_id=info%3Adoi%2F10.1353%2Fpbm.1967.0031&amp;rft.aulast=Page&amp;rft.aufirst=IH&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20061026072848/http://www.time.com/time/covers/0%2C16641%2C19551031%2C00.html">issue</a></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://achievement.org/our-history/golden-plate-awards/#science-exploration">"Golden Plate Awardees of the American Academy of Achievement"</a>. <i>www.achievement.org</i>. <a href="/wiki/American_Academy_of_Achievement" class="mw-redirect" title="American Academy of Achievement">American Academy of Achievement</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20161215023909/https://achievement.org/our-history/golden-plate-awards/#science-exploration">Archived</a> from the original on 2016-12-15<span class="reference-accessdate">. Retrieved <span class="nowrap">2020-05-12</span></span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=www.achievement.org&amp;rft.atitle=Golden+Plate+Awardees+of+the+American+Academy+of+Achievement&amp;rft_id=https%3A%2F%2Fachievement.org%2Four-history%2Fgolden-plate-awards%2F%23science-exploration&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://oculus.nlm.nih.gov/page386">"Irvine H. Page, M.D. Papers 1917–1989"</a>. National Library of Medicine.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Irvine+H.+Page%2C+M.D.+Papers+1917%E2%80%931989&amp;rft.pub=National+Library+of+Medicine&amp;rft_id=http%3A%2F%2Foculus.nlm.nih.gov%2Fpage386&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AIrvine+Page" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Irvine_Page&amp;action=edit&amp;section=8" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/page-irvine.pdf">Harriet P. 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<li>Children's Rehabilitation</li> <li><a href="/wiki/Cleveland_Clinic" title="Cleveland Clinic">Cleveland Clinic</a></li> <li>Euclid</li> <li>Fairview</li> <li><a href="/wiki/Cleveland_Clinic_Hillcrest_Hospital" title="Cleveland Clinic Hillcrest Hospital">Hillcrest</a></li> <li>Lodi</li> <li>Lutheran</li> <li><a href="/wiki/Cleveland_Clinic_Marymount_Hospital" title="Cleveland Clinic Marymount Hospital">Marymount</a></li> <li>Medina</li> <li>Mentor</li> <li>Mercy</li> <li>South Pointe</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#247C3E; color:#FFFFFF; box-shadow: inset 2px 2px 0 #0960A9, inset -2px -2px 0 #0960A9;">Florida</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Indian River</li> <li>Martin North</li> <li>Martin South</li> <li>Tradition</li> <li>Weston</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#247C3E; color:#FFFFFF; box-shadow: inset 2px 2px 0 #0960A9, inset -2px -2px 0 #0960A9;">United Kingdom</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cleveland_Clinic_London" title="Cleveland Clinic London">London</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#247C3E; color:#FFFFFF; box-shadow: inset 2px 2px 0 #0960A9, inset -2px -2px 0 #0960A9;">United Arab Emirates</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cleveland_Clinic_Abu_Dhabi" title="Cleveland Clinic Abu Dhabi">Abu Dhabi</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="background:#2a5fa4; color:#FFFFFF; box-shadow: inset 2px 2px 0 #0960A9, inset -2px -2px 0 #0960A9;;width:1%">History</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/History_of_Cleveland_Clinic" title="History of Cleveland Clinic">History of Cleveland Clinic</a></li> <li>Founder: <a href="/wiki/George_Washington_Crile" title="George Washington Crile">George Washington Crile</a></li> <li><a href="/wiki/Cleveland_Clinic_fire_of_1929" title="Cleveland Clinic fire of 1929">Cleveland Clinic fire of 1929</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="background:#2a5fa4; color:#FFFFFF; box-shadow: inset 2px 2px 0 #0960A9, inset -2px -2px 0 #0960A9;;width:1%">Education</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Case_Western_Reserve_University_School_of_Medicine" title="Case Western Reserve University School of Medicine">Case Western Reserve University School of Medicine</a></li> <li><a href="/wiki/Case_School_of_Dental_Medicine" title="Case School of Dental Medicine">Case School of Dental Medicine</a></li> <li><i><a href="/wiki/Cleveland_Clinic_Journal_of_Medicine" title="Cleveland Clinic Journal of Medicine">Cleveland Clinic Journal of Medicine</a></i></li> <li><a href="/wiki/Frances_Payne_Bolton_School_of_Nursing" title="Frances Payne Bolton School of Nursing">Frances Payne Bolton School of Nursing</a></li> <li><a href="/wiki/Health_Education_Campus" title="Health Education Campus">Health Education Campus</a></li> <li><a href="/wiki/Lou_Ruvo_Center_for_Brain_Health" class="mw-redirect" title="Lou Ruvo Center for Brain Health">Lou Ruvo Center for Brain Health</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="background:#2a5fa4; color:#FFFFFF; box-shadow: inset 2px 2px 0 #0960A9, inset -2px -2px 0 #0960A9;;width:1%">People</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/D._S._Rana" title="D. S. Rana">D. S. Rana</a></li> <li><a href="/wiki/Mohammad_Zahid_Ashraf" title="Mohammad Zahid Ashraf">Mohammad Zahid Ashraf</a></li> <li><a href="/wiki/Leonard_Calabrese" title="Leonard Calabrese">Leonard Calabrese</a></li> <li><a href="/wiki/Debasis_Chattopadhyay" title="Debasis Chattopadhyay">Debasis Chattopadhyay</a></li> <li><a href="/wiki/Conor_P._Delaney" title="Conor P. Delaney">Conor P. Delaney</a></li> <li><a href="/wiki/Toby_Cosgrove" title="Toby Cosgrove">Toby Cosgrove</a></li> <li><a href="/wiki/Harriet_P._Dustan" title="Harriet P. Dustan">Harriet P. Dustan</a></li> <li><a href="/wiki/Charis_Eng" title="Charis Eng">Charis Eng</a></li> <li><a href="/wiki/Ren%C3%A9_Favaloro" title="René Favaloro">René Favaloro</a></li> <li><a href="/wiki/A._Marc_Gillinov" title="A. Marc Gillinov">A. Marc Gillinov</a></li> <li><a href="/wiki/Steven_Nissen" title="Steven Nissen">Steven Nissen</a></li> <li><a class="mw-selflink selflink">Irvine Page</a></li> <li><a href="/wiki/Michael_Roizen" title="Michael Roizen">Michael Roizen</a></li> <li><a href="/wiki/F._Mason_Sones" title="F. Mason Sones">F. Mason Sones</a></li> <li><a href="/wiki/Lars_Georg_Svensson" title="Lars Georg Svensson">Lars Georg Svensson</a></li> <li><a href="/wiki/Eric_Topol" title="Eric Topol">Eric Topol</a></li> <li><a href="/wiki/Elias_Traboulsi" title="Elias Traboulsi">Elias Traboulsi</a></li> <li><a href="/wiki/Steven_D._Wexner" title="Steven D. Wexner">Steven D. Wexner</a></li> <li><a href="/wiki/Steven_E._Wilson" title="Steven E. Wilson">Steven E. Wilson</a></li></ul> </div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐764b6bb99c‐4mmww Cached time: 20241121173212 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.377 seconds Real time usage: 0.541 seconds Preprocessor visited node count: 2426/1000000 Post‐expand include size: 48873/2097152 bytes Template argument size: 1241/2097152 bytes Highest expansion depth: 14/100 Expensive parser function count: 1/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 48737/5000000 bytes Lua time usage: 0.278/10.000 seconds Lua memory usage: 6228674/52428800 bytes Number of Wikibase entities loaded: 1/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 492.222 1 -total 47.29% 232.781 1 Template:Infobox_scientist 20.67% 101.734 1 Template:Birth_date 17.95% 88.342 3 Template:Cite_book 15.08% 74.214 1 Template:Authority_control 10.63% 52.312 1 Template:Reflist 6.16% 30.300 1 Template:Cleveland_Clinic 5.88% 28.963 2 Template:Navbox 4.06% 19.986 4 Template:Cite_journal 3.91% 19.243 20 Template:Pluralize_from_text --> <!-- Saved in parser cache with key enwiki:pcache:idhash:9411418-0!canonical and timestamp 20241121173212 and revision id 1245113945. 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