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id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <input type="hidden" name="ctl00$RootHolder$SortedValue" id="SortedValue" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">1244</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (166)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (297)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Receptors, Chimeric Antigen/immunology</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> 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style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Abba Moussa D</b>, Vazquez M, Chable-Bessia C, Roux-Portalez V, Tamagnini E, Pedotti M, Simonelli L, Ngo G, Souchard M, Lyonnais S, Chentouf M, Gros N, Marsile-Medun S, Dinter H, Pugnière M, Martineau P, Varani L, Juan M, Calderon H, Naranjo-Gomez M, Pelegrin M. Discovery of a pan anti-SARS-CoV-2 monoclonal antibody with highly efficient infected cell killing capacity for novel immunotherapeutic approaches. <em class='incite-journal-name' onclick='ShowInCiteJournal(8182);'>Emerg Microbes Infect</em> 2025;<b>14</b>:2432345. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39584380' target='_blank'>39584380</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632933' target='_blank'>PMC11632933</a> DOI: <a href='https://dx.doi.org/10.1080/22221751.2024.2432345' target='_blank'>10.1080/22221751.2024.2432345</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/22221751.2024.2432345','39584380', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1080/22221751.2024.2432345' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8182);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/26/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1080/22221751.2024.2432345" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Unlocking the potential of broadly reactive coronavirus monoclonal antibodies (mAbs) and their derivatives offers a transformative therapeutic avenue against severe COVID-19, especially crucial for safeguarding high-risk populations. Novel mAb-based immunotherapies may help address the reduced efficacy of current vaccines and neutralizing mAbs caused by the emergence of variants of concern (VOCs). Using phage display technology, we discovered a pan-SARS-CoV-2 mAb (C10) that targets a conserved region within the receptor-binding domain (RBD) of the virus. Noteworthy, C10 demonstrates exceptional efficacy in recognizing all assessed VOCs, including recent Omicron variants. While C10 lacks direct neutralization capacity, it efficiently binds to infected lung epithelial cells and induces their lysis via natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC). Building upon this pan-SARS-CoV-2 mAb, we engineered C10-based, Chimeric Antigen Receptor (CAR)-T cells endowed with efficient killing capacity against SARS-CoV-2-infected lung epithelial cells. Notably, NK and CAR-T-cell mediated killing of lung infected cells effectively reduces viral titers. These findings highlight the potential of non-neutralizing mAbs in providing immune protection against emerging infectious diseases. Our work reveals a pan-SARS-CoV-2 mAb effective in targeting infected cells and demonstrates the proof-of-concept for the potential application of CAR-T cell therapy in combating SARS-CoV-2 infections. Furthermore, it holds promise for the development of innovative antibody-based and cell-based therapeutic strategies against severe COVID-19 by expanding the array of therapeutic options available for high-risk populations.Trial registration: ClinicalTrials.gov identifier: NCT04093596. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-neutralizing+antibodies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-neutralizing antibodies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antibody-based+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antibody-based therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22infected+cell-targeting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">infected cell-targeting</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Neutralizing%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Neutralizing/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Viral%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Viral/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibody-Dependent+Cell+Cytotoxicity%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibody-Dependent Cell Cytotoxicity/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fvirology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/virology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Killer+Cells%2c+Natural%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Killer Cells, Natural/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spike+Glycoprotein%2c+Coronavirus%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spike Glycoprotein, Coronavirus/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+Trials%2c+Phase+I+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical Trials, Phase I as Topic</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Li H</b>, Wang Z, Hu Y, He G, Huang L, Liu Y, Wang ZL, Jiang P. Enhancing CAR-T cell therapy against solid tumor by drug-free triboelectric immunotherapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122871. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39368275' target='_blank'>39368275</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122871' target='_blank'>10.1016/j.biomaterials.2024.122871</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122871','39368275', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.biomaterials.2024.122871' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.biomaterials.2024.122871" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Chimeric antigen receptor (CAR) T cell therapy is a highly effective immunotherapy for hematological tumors, but its efficacy against most solid tumors remains challenging. Herein, a novel synergistic combination therapy of drug-free triboelectric immunotherapy and CAR-T cell therapy against solid tumor was proposed. A triboelectric nanogenerator (TENG) that can generate pulsed direct-current by coupling triboelectrification effect and electrostatic breakdown effect was fabricated. The TENG can generate up to 30 pulse direct-current peaks with peak current output ≈35 μA in a single sliding to power the triboelectric immunotherapy. The pulsed direct-current stimulation induced immunogenic cell death of tumor cells (survival rate of 35.9 %), which promoted dendritic cells maturation, accelerated the process of antigen presentation to CAR-T cells and enhanced the systemic adaptive immune response. Furthermore, triboelectric immunotherapy promoted M1-like macrophage polarization, reduced regulatory T cells differentiation and reprogrammed the tumor immunosuppressive microenvironment, which ultimately enhanced the efficacy of CAR-T cells to eradicate nearly 60 % of NALM6 solid tumor mass. Notably, considering that triboelectric immunotherapy is a safe and effective drug-free antitumor strategy, the combined therapy did not increase the burden of double-medication on patients. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunosuppressive+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunosuppressive microenvironment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Solid+tumor+treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Solid tumor treatment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Triboelectric+immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Triboelectric immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Triboelectric+nanogenerator%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Triboelectric nanogenerator</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Shin SH</b>, Lee YE, Yoon HN, Yuk CM, An JY, Seo M, Yoon S, Oh MS, Shin SC, Kim JH, Kim YJ, Kim JC, Kim SC, Jang M. An innovative strategy harnessing self-activating CAR-NK cells to mitigate TGF-β1-driven immune suppression. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122888. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39423512' target='_blank'>39423512</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122888' target='_blank'>10.1016/j.biomaterials.2024.122888</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122888','39423512', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122888' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.biomaterials.2024.122888" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The dysfunction of natural killer (NK) cells, mediated by transforming growth factor β1 (TGFβ1) within the tumor microenvironment, impedes antitumor therapy and contributes to poor clinical outcomes. Our study introduces self-activating chimeric antigen receptor (CAR)-NK cells that block TGFβ1 signaling by releasing a specifically designed peptide, P6, which targets mesothelin in pancreatic tumors. P6 originates from the interaction sites between TGFβ1 and TGFβ receptor 1 and effectively disrupts TGFβ1's inhibitory signaling in NK cells. Our analysis demonstrates that P6 treatment interrupts the SMAD2/3 pathway in NK cells, mitigating TGFβ1-mediated suppression of NK cell activity, thereby enhancing their metabolic function and cytotoxic response against pancreatic tumors. These CAR-NK cells exhibit potent antitumor capabilities, as evidenced in spheroid cultures with cancer-associated fibroblasts and in vivo mouse models. Our approach marks a substantial advancement in overcoming TGFβ1-mediated immune evasion, offering a promising avenue for revolutionizing cancer immunotherapy. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chimeric+antigen+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chimeric antigen receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+killer+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural killer cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Solid+tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Solid tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TGF%ce%b2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TGFβ</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor microenvironment</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transforming+Growth+Factor+beta1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transforming Growth Factor beta1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Killer+Cells%2c+Natural%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Killer Cells, Natural/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Killer+Cells%2c+Natural%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Killer Cells, Natural/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesothelin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesothelin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreatic+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreatic Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreatic+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreatic Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pancreatic+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pancreatic Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Xing R</b>, Wang M, Wang L, Pan M, Wang Y, Zhou H. Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review). <em class='incite-journal-name' onclick='ShowInCiteJournal(11723);'>Int J Mol Med</em> 2025;<b>55</b>:27. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39670288' target='_blank'>39670288</a> DOI: <a href='https://dx.doi.org/10.3892/ijmm.2024.5468' target='_blank'>10.3892/ijmm.2024.5468</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3892/ijmm.2024.5468','39670288', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.3892/ijmm.2024.5468' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11723);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/14/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.3892/ijmm.2024.5468" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Despite significant progress in managing multiple myeloma (MM) in recent years, certain patients still have a short duration of therapeutic response, often relapsing within 18 months. These patients typically have high‑risk genetic mutations and may show little to no response to current treatments, highlighting the need for further exploration of optimal therapeutic targets for MM. B‑cell maturation antigen (BCMA), highly expressed in mature B lymphocytes and plasma cells and upregulated in MM, is a promising therapeutic target. Various BCMA‑targeted strategies, including antibody‑drug conjugates, bispecific T‑cell engagers and chimeric antigen receptor T‑cell therapy, are under clinical evaluation to optimize efficacy and safety. This review summarizes the latest clinical updates on these strategies, highlights their effectiveness in MM and relapsed/refractory MM and provides future perspectives and recommendations for overcoming current challenges. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B%e2%80%91cell+maturation+antigen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B‑cell maturation antigen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR%e2%80%91T+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR‑T cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Key+words%3a+multiple+myeloma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Key words: multiple myeloma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antibody%e2%80%91drug+conjugates%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antibody‑drug conjugates</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bispecific+T%e2%80%91cell+engagers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bispecific T‑cell engagers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22relapsed%2frefractory+multiple+myeloma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">relapsed/refractory multiple myeloma</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+Myeloma%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple Myeloma/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+Myeloma%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple Myeloma/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+Myeloma%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple Myeloma/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-Cell+Maturation+Antigen%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-Cell Maturation Antigen/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-Cell+Maturation+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-Cell Maturation Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-Cell+Maturation+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-Cell Maturation Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Targeted+Therapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Targeted Therapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunoconjugates%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunoconjugates/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Duell J</b>, Westin J. The future of immunotherapy for diffuse large B-cell lymphoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(11478);'>Int J Cancer</em> 2025;<b>156</b>:251-261. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39319495' target='_blank'>39319495</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578085' target='_blank'>PMC11578085</a> DOI: <a href='https://dx.doi.org/10.1002/ijc.35156' target='_blank'>10.1002/ijc.35156</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/ijc.35156','39319495', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(5);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/ijc.35156' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11478);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/26/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1002/ijc.35156" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">With the introduction of anti-CD19 chimeric antigen receptor (CAR) T-cell (CAR T) therapies, bispecific CD3/CD20 antibodies and anti-CD19 antibodies, immunotherapy continues to transform the treatment of diffuse large B-cell lymphoma (DLBCL). A number of novel immunotherapeutic strategies are under investigation to build upon current clinical benefit and offer further options to those patients who cannot tolerate conventional intensive therapies due to their age and/or state of health. Alongside immunotherapies that leverage the adaptive immune response, natural killer (NK) cell and myeloid cell-engaging therapies can utilize the innate immune system. Monoclonal antibodies engineered for greater recognition by the patient's immune system can enhance antitumor cytotoxic mechanisms mediated by NK cells and macrophages. In addition, CAR technology is extending into NK cells and macrophages and investigational immune checkpoint inhibitors targeting macrophage/myeloid cell checkpoints via the CD47/SIRPα axis are in development. Regimens that engage both innate and adaptive immune responses may help to overcome resistance to current immunotherapies. Furthermore, combinations of immunotherapy and oncogenic pathway inhibitors to reprogram the immunosuppressive tumor microenvironment of DLBCL may also potentiate antitumor responses. As immunotherapy treatment options continue to expand, both in the first-line setting and further lines of therapy, understanding how to harness these immunotherapies and the potential for combination approaches will be important for the development of future DLBCL treatment approaches. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DLBCL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DLBCL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diffuse+large+B%e2%80%90cell+lymphoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diffuse large B‐cell lymphoma</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+Large+B-Cell%2c+Diffuse%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, Large B-Cell, Diffuse/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+Large+B-Cell%2c+Diffuse%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, Large B-Cell, Diffuse/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2ftrends%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/trends</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Killer+Cells%2c+Natural%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Killer Cells, Natural/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+Checkpoint+Inhibitors%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune Checkpoint Inhibitors/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Incyte+Corporation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Incyte Corporation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MorphoSys+AG%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MorphoSys AG</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Incyte+Corporation%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Incyte Corporation </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MorphoSys+AG%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MorphoSys AG </a></li></ul> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Bhat AA</b>, Altamimi ASA, Goyal A, Goyal K, Kaur I, Kumar S, Sharma N, Kumar MR, Ali H, Thapa R, Negi P, Singh SK, Gupta G. The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2025;<b>144</b>:113675. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39608172' target='_blank'>39608172</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113675' target='_blank'>10.1016/j.intimp.2024.113675</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113675','39608172', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.intimp.2024.113675' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.intimp.2024.113675" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">CAR T cell therapy has revolutionized how we deliver cancer treatment, most notably for hematologic cancers, by compelling T cells to recognize and kill tumor cells. Nevertheless, current obstacles to utilizing this therapy in solid tumors and overcoming cancer resistance include radicalization. This review discusses how CD95 modulation can boost CAR T cell efficacy. Traditionally, CD95 was known to execute apoptosis induction, but it plays a dual role in induced cell death or in supporting cancer cell survival. Recent data have demonstrated that cancer cells escape CD95-mediated apoptosis via the downregulation of CD95, caspase 8 mutation, or the expression of the inhibition protein cFLIP. Additionally, the immunosuppressive tumor microenvironment, containing CD95L expressing immune cells, explains CAR T cell therapy resistance. Furthermore, we characterize the therapeutic potential of CD95 targeted approaches, including CD95L inhibition (APG101) and alterations in CAR T cell manufacturing (tyrosine kinase inhibitors to mitigate fratricide). In this review, we highlight the importance of multi-path way strategies combining CD95 modulation with CAR T cell engineering to overcome resistance, specifically to target tumor cells better and sustain CAR T cell persistence to enhance treatment efficacy in solid tumors. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR+T-cell+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR T-cell therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD95%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD95</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD95L+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD95L inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immuno-oncology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immuno-oncology</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fas+Receptor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fas Receptor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fas+Receptor%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fas Receptor/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Agarwal D</b>, Sharma G, Khadwal A, Toor D, Malhotra P. Advances in Vaccines, Checkpoint Blockade, and Chimeric Antigen Receptor-Based Cancer Immunotherapeutics. <em class='incite-journal-name' onclick='ShowInCiteJournal(7234);'>Crit Rev Immunol</em> 2025;<b>45</b>:65-80. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39612278' target='_blank'>39612278</a> DOI: <a href='https://dx.doi.org/10.1615/critrevimmunol.2024053025' target='_blank'>10.1615/critrevimmunol.2024053025</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1615/critrevimmunol.2024053025','39612278', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1615/critrevimmunol.2024053025' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7234);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/01/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1615/critrevimmunol.2024053025" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Increase in cancer cases and research driven by understanding its causes, facilitated development of novel targeted immunotherapeutic strategies to overcome nonspecific cytotoxicity associated with conventional chemotherapy and radiotherapy. These target specific immunotherapeutic regimens have been evaluated for their efficacy, including: (1) vaccines harnessing tumor specific/associated antigens, (2) checkpoint blockade therapy using monoclonal antibodies against PD1, CTLA-4 and others, and (3) adoptive cell transfer approaches viz. chimeric antigen receptor (CAR)-cell-based therapies. Here, we review recent advancements on these target specific translational immunotherapeutic strategies against cancer/s and concerned limitations. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+Checkpoint+Inhibitors%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune Checkpoint Inhibitors/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+Vaccines%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer Vaccines/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+Vaccines%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer Vaccines/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+Neoplasm%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, Neoplasm/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Zhang YT</b>, Fu X, Ting Lim JJ, Zhang SX. Engraftment of a surrogate antigen onto tumor cell surface via pHLIP peptide to universally target CAR-T cell therapy to solid tumors. <em class='incite-journal-name' onclick='ShowInCiteJournal(4471);'>Cancer Lett</em> 2025;<b>608</b>:217319. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39489212' target='_blank'>39489212</a> DOI: <a href='https://dx.doi.org/10.1016/j.canlet.2024.217319' target='_blank'>10.1016/j.canlet.2024.217319</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.canlet.2024.217319','39489212', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.canlet.2024.217319' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4471);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.canlet.2024.217319" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">CAR-T cells and monoclonal antibodies (mAbs) are immunotherapeutics that have shown efficacies against certain malignancies. However, their broad application is hindered by the scarcity of tumor-associated antigens on tumor cell surfaces. Previous investigations unveiled the unique capacity of pH-low insertion peptide (pHLIP) to anchor to plasma membranes under acidic conditions. Considering that an acidic tumor microenvironment is a hallmark of solid tumors, we engineered a novel peptide, Myc-pHLIP, by tethering a surrogate epitope tag, the c-Myc-tag, to pHLIP. We evaluated the efficiency of Myc-pHLIP in inserting the artificial c-Myc-tag onto the plasma membrane of malignant cells and determined if this engraftment could convert it into a therapeutic target for CAR-T cells or mAbs. Our in vitro experiments demonstrated that incubating Myc-pHLIP with tumor cells in acidic media triggered significant killing by either Myc-targeted CAR-T cells (Myc-CAR-T), or by an anti-Myc mAb in the presence of NK cells. In vivo studies demonstrated substantial antitumor effects with sequential administration of Myc-pHLIP followed by either Myc-CAR-T or Myc-mAb. These findings establish that Myc-pHLIP has the potential to act as a universal surrogate tumor antigen capable of directing CAR-T cells or mAbs to treat any solid tumors by concurrently targeting both malignant and stromal cells. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibody+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibody therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Surrogate+tumor+antigen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Surrogate tumor antigen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Targeting+acidic+tumor+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Targeting acidic tumor microenvironment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pHLIP+peptide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pHLIP peptide</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" 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href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Morabito F</b>, Martino EA, Nizzoli ME, Talami A, Pozzi S, Martino M, Neri A, Gentile M. Comparative Analysis of Bispecific Antibodies and CAR T-Cell Therapy in Follicular Lymphoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(8845);'>Eur J Haematol</em> 2025;<b>114</b>:4-16. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39462177' target='_blank'>39462177</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613673' target='_blank'>PMC11613673</a> DOI: <a href='https://dx.doi.org/10.1111/ejh.14335' target='_blank'>10.1111/ejh.14335</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/ejh.14335','39462177', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1111/ejh.14335' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8845);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/29/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1111/ejh.14335" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The treatment landscape for relapsed/refractory follicular lymphoma (RR-FL) is marked by a pivotal debate between chimeric antigen receptor T-cell (CAR-T) therapy and bispecific antibodies (BsAbs). While both CAR-T therapy and BsAbs target similar immunobiology and molecular markers, their efficacy comparisons are hindered by the lack of direct clinical trial comparisons. Key trials, such as the ZUMA-5 study, underscore axicabtagene ciloleucel (axi-cel)'s efficacy in treating RR-FL, achieving a 79% complete response rate with a median duration of response exceeding 3 years. Similarly, lisocabtagene maraleucel (liso-cel) in the TRANSCEND FL study reports a 94% complete response rate, emphasizing robust outcomes in heavily pretreated patients. Among BsAbs, mosunetuzumab showed promise in the GO29781 trial, with a 62% overall response rate in heavily pretreated RR-FL patients. Thus, CAR-T therapy offers potential curative benefits with a single infusion. However, its efficacy is tempered by significant adverse events such as cytokine release syndrome (CRS), neurotoxicity, and cytopenias, requiring specialized management and patient monitoring. In contrast, BsAbs provide a more tolerable treatment option counterbalancing by lower response rates and frequent dosing requirements. Personalized treatment strategies are crucial because of these distinct efficacy and safety profiles. When considering cost-effectiveness, both therapies need to be evaluated in the context of their clinical outcomes and quality of life improvements. Cost-effectiveness considerations are essential; while CAR-T therapies incur higher initial costs, their potential for long-term remission may mitigate expenses associated with repeated treatments or hospitalizations. Future research into resistance mechanisms and optimal therapeutic sequencing will further refine RR-FL management strategies. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BsAbs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BsAbs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR%e2%80%90T%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR‐T</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cost%e2%80%90effectiveness%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cost‐effectiveness</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22follicular+lymphoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">follicular lymphoma</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+Follicular%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, Follicular/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+Follicular%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, Follicular/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Bispecific%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Bispecific/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+Trials+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical Trials as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Combined+Modality+Therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Combined Modality Therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2c+Immunological%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents, Immunological/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Management%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Management</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Zabaleta A</b>, Puig N, Cedena M, Oliver‐Caldes A, Perez JJ, Moreno C, Tamariz‐Amador L, Rodriguez‐Otero P, Prosper F, Gonzalez‐Calle V, López‐Corral L, Rey‐Búa B, Puertas B, Mirás F, Sánchez‐Pina JM, López‐Muñoz N, Juan M, González‐Navarro EA, Urbano Á, de Larrea CF, Blade J, Lahuerta J, Martinez‐Lopez J, Mateos M, San Miguel JF, Paiva B. Clinical significance of complete remission and measurable residual disease in relapsed/refractory multiple myeloma patients treated with T-cell redirecting immunotherapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(1596);'>Am J Hematol</em> 2025;<b>100</b>:93-102. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39548827' target='_blank'>39548827</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625977' target='_blank'>PMC11625977</a> DOI: <a href='https://dx.doi.org/10.1002/ajh.27526' target='_blank'>10.1002/ajh.27526</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/ajh.27526','39548827', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(10);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1002/ajh.27526' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(1596);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1002/ajh.27526" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The impact of measurable residual disease (MRD) in relapse/refractory multiple myeloma (RRMM) patients treated with T-cell redirecting immunotherapy is uncertain. We analyzed MRD dynamics using next-generation flow in 201 patients treated in clinical trials with chimeric antigen receptor (CAR) T cells and T-cell engagers (TCE). Achieving MRD negativity at 10-6 was associated with 89% reduction in the risk of progression and/or death. Survival outcomes were improved in patients with sustained versus transient MRD negativity and were dismal in those who remained MRD positive. The intent-to-treat MRD negative rates were higher in patients treated with CAR T cells versus TCE. However, among patients achieving MRD negativity, there were no differences in survival outcomes when stratified according to treatment with CAR T cells versus TCE. In multivariate analysis including the number of prior lines of treatment, International Staging System, cytogenetic risk, extramedullary disease and type of T-cell redirecting immunotherapy, only the complete remission (CR) and MRD statuses showed independent prognostic value for progression-free and overall survival. In conclusion, our study shows that deep and sustained MRD negative CR is the most relevant prognostic factor and should be considered as the treatment endpoint in RRMM patients treated with CAR T cells and TCE. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+Myeloma%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple Myeloma/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+Myeloma%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple Myeloma/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+Myeloma%2fmortality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple Myeloma/mortality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm%2c+Residual%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm, Residual</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Remission+Induction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Remission Induction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Recurrence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Recurrence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+Relevance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical Relevance</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CIBER-Consorcio+Centro+de+Investigaci%c3%b3n+Biom%c3%a9dica+en+Red+-+%c3%81rea+de+Oncolog%c3%ada+-+Instituto+de+Salud+Carlos+III%2c+Ministerio+de+Ciencia+e+Innovaci%c3%b3n%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB16/12/00233 CIBER-Consorcio Centro de Investigación Biomédica en Red - Área de Oncología - Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CIBER-Consorcio+Centro+de+Investigaci%c3%b3n+Biom%c3%a9dica+en+Red+-+%c3%81rea+de+Oncolog%c3%ada+-+Instituto+de+Salud+Carlos+III%2c+Ministerio+de+Ciencia+e+Innovaci%c3%b3n%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB16/12/00369 CIBER-Consorcio Centro de Investigación Biomédica en Red - Área de Oncología - Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CIBER-Consorcio+Centro+de+Investigaci%c3%b3n+Biom%c3%a9dica+en+Red+-+%c3%81rea+de+Oncolog%c3%ada+-+Instituto+de+Salud+Carlos+III%2c+Ministerio+de+Ciencia+e+Innovaci%c3%b3n%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CB16/12/00489 CIBER-Consorcio Centro de Investigación Biomédica en Red - Área de Oncología - Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Instituto+de+Salud+Carlos+III%2fSubdirecci%c3%b3n+General+de+Investigaci%c3%b3n+Sanitaria%2c+(cofunded+by+the+EU)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ICI19/00025 Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria, (cofunded by the EU)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Instituto+de+Salud+Carlos+III%2fSubdirecci%c3%b3n+General+de+Investigaci%c3%b3n+Sanitaria%2c+(cofunded+by+the+EU)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PI19/01451 Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria, (cofunded by the EU)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Instituto+de+Salud+Carlos+III%2fSubdirecci%c3%b3n+General+de+Investigaci%c3%b3n+Sanitaria%2c+(cofunded+by+the+EU)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PI21/01816 Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria, (cofunded by the EU)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Instituto+de+Salud+Carlos+III%2fSubdirecci%c3%b3n+General+de+Investigaci%c3%b3n+Sanitaria%2c+(cofunded+by+the+EU)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PI22/00647 Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria, (cofunded by the EU)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+Research+UK+(A26819)%2c+FCAECC+and+AIRC+under+the+Accelerator+Award+Programme+(EDITOR)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer Research UK (A26819), FCAECC and AIRC under the Accelerator Award Programme (EDITOR)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Black+Swan+Research+Initiative+of+the+International+Myeloma+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Black Swan Research Initiative of the International Myeloma Foundation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CRIS+Cancer+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PR_EX_2020-02 CRIS Cancer Foundation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22La+Caixa+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CP042702/LCF/PR/GN18/50310007 La Caixa Foundation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fundaci%c3%b3n+Cient%c3%adfica+Asociaci%c3%b3n+Espa%c3%b1ola+Contra+el+C%c3%a1ncer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fundación Científica Asociación Española Contra el Cáncer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Riney+Family+Multiple+Myeloma+Research+Program%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Riney Family Multiple Myeloma Research Program</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Instituto+de+Salud+Carlos+III%2fSubdirecci%c3%b3n+General+de+Investigaci%c3%b3n+Sanitaria%2c+(cofunded+by+the+EU)%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria, (cofunded by the EU) </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CRIS+Cancer+Foundation%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CRIS Cancer Foundation </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fundaci%c3%b3n+Cient%c3%adfica+Asociaci%c3%b3n+Espa%c3%b1ola+Contra+el+C%c3%a1ncer%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fundación Científica Asociación Española Contra el Cáncer </a></li></ul> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Jewett A</b>, Memarzadeh S, Kaur K. Commentary: Ovarian Cancer: Path to Effective Treatments. <em class='incite-journal-name' onclick='ShowInCiteJournal(7234);'>Crit Rev Immunol</em> 2025;<b>45</b>:93-99. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39612280' target='_blank'>39612280</a> DOI: <a href='https://dx.doi.org/10.1615/critrevimmunol.2024053766' target='_blank'>10.1615/critrevimmunol.2024053766</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1615/critrevimmunol.2024053766','39612280', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1615/critrevimmunol.2024053766' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7234);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/01/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1615/critrevimmunol.2024053766" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Despite advancements in cancer therapeutics such as checkpoint inhibitors and some targeted therapies, we have not achieved success in effectively treating ovarian cancer, since these therapeutics only benefit a subset of patients, and also provide short-term protection. The use of chemotherapy and radiation therapy can cause depletion and/or lack of immune cells' function. Chimeric antigen receptor T (CAR-T) cell therapy is found to be effective against several blood-based cancers, but limited success was seen against solid tumors. Targeting fewer antigens and significant side effects of therapy decreases the efficacy of CAR-T cells as immunotherapeutic in solid tumors, even though there is a great drive and significant effort to establish these therapies around the world. Bispecific and tri-specific antibodies have recently been advocated as effective cancer therapeutics. However, at present, these also suffer the fate of CAR-Ts since the loss of antigen on tumor cells will render these therapeutics ineffective. At present, we should design therapeutics that may have synergistic effects on killing/treating tumors. The only way we can establish that will be by learning the mechanisms of actions of immune therapeutics. Thus, advancement in the knowledge and effective strategies are required to develop cancer immuno-therapeutics. We have dedicated our efforts to understand the immunobiology of natural killer (NK) cells. One of our most important discoveries was demonstration of targeting of cancer stem-like cells (CSCs)/poorly differentiated tumors exhibiting lower major histocompability complex class I expression by the NK cells. In addition, we showed that supercharged NK (sNK) cells had great ability to target both CSCs/poorly differentiated and well differentiated ovarian tumors, whereas activated primary NK cells only targeted CSCs/poorly differentiated tumors. Therefore, the use of sNK cells in immunotherapy should result in effective elimination of heterogeneous populations of ovarian tumors. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Han K</b>, Wang X, Chen G, Liu W, Mei X, Yang Y, Xu X. Targeted therapy of multiple myeloma by IL21-NKG2D CAR-T cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(169108);'>J Investig Med</em> 2025;<b>73</b>:45-53. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39373147' target='_blank'>39373147</a> DOI: <a href='https://dx.doi.org/10.1177/10815589241291846' target='_blank'>10.1177/10815589241291846</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/10815589241291846','39373147', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1177/10815589241291846' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169108);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/08/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1177/10815589241291846" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">NKG2D chimeric antigen receptor (CAR)-modified T cells (NKG2D CAR-T cells) have been reported to be preclinically efficient in several tumors, but little is known whether NKG2D CAR-T cells co-expressing IL21 (IL21-NKG2D CAR-T cells) display greater antitumor activity in multiple myeloma (MM). In this study, the lentivirus has been produced for expression of the IL21 sequence linked to the extracellular NKG2D sequence with the signal peptide linked through the CD8α hinge-transmembrane domain to the 4-1BB molecule fused with the CD3-ζ chain signaling domain, and the engineered IL21-NKG2D CAR-T cells and NKG2D CAR-T cells were constructed. The CAR expression on CAR-T cells was assessed by flow cytometry, and the killing effects of CAR-T cells on MM were assessed by the cytotoxicity assay and ELISA assay. Moreover, xenograft models were also established to evaluate the ability of IL21-NKG2D-CAR-T cells to eliminate MM in vivo. Our results indicated that NKG2D CAR-T cells had dramatic cytotoxicity on MM cells in vitro, and co-expression of IL-21 significantly increased the cytotoxicity of NKG2D CAR-T cells on MM cells. Remarkably, we found that dexamethasone enhanced the cytotoxicity of IL21-NKG2D CAR-T cells on MM cells. Furthermore, IL21-NKG2D CAR-T cells also displayed significant anti-myeloma activity in vivo. In conclusion, IL21-NKG2D CAR-T cells had dramatic cytotoxicity on MM cells in vitro and in vivo, and a system to apply IL21-NKG2D CAR-T cells and low dosage of dexamethasone for the future study of the targeted therapy for MM has been established. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IL21%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IL21</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+myeloma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple myeloma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NKG2D%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NKG2D</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dexamethasone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dexamethasone</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple+Myeloma%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple Myeloma/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NK+Cell+Lectin-Like+Receptor+Subfamily+K%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NK Cell Lectin-Like Receptor Subfamily K/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xenograft+Model+Antitumor+Assays%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xenograft Model Antitumor Assays</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Targeted+Therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Targeted Therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Wallington DG</b>, Imber BS, Scordo M, Robinson TJ. The Role of Radiotherapy in Lymphoma Patients Undergoing CAR T Therapy: Past, Present, and Future. <em class='incite-journal-name' onclick='ShowInCiteJournal(21073);'>Semin Radiat Oncol</em> 2025;<b>35</b>:99-109. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39672646' target='_blank'>39672646</a> DOI: <a href='https://dx.doi.org/10.1016/j.semradonc.2024.10.005' target='_blank'>10.1016/j.semradonc.2024.10.005</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.semradonc.2024.10.005%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.semradonc.2024.10.005')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.semradonc.2024.10.005','39672646', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.semradonc.2024.10.005' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21073);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.semradonc.2024.10.005" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Chimeric antigen receptor (CAR) T-cell receptor therapy has transformed outcomes for patients with relapsed and refractory diffuse large B-cell lymphoma (R/R DLBCL). It is currently approved in the third line for all patients and in the second line for early relapsed or primary refractory disease. Although CAR T cell therapy offers the potential for improved outcomes, its use may also include logistical delays related to referral, medical, social, and financial clearance as well as manufacturing time; more than half of patients experience disease recurrence or progression while awaiting CAR T infusion. Bridging radiotherapy, defined as radiation delivered between the decision to pursue CAR T and infusion of CAR T cells, has become an attractive option for patients who would benefit from local disease control or palliation of symptoms. Additionally, patterns of failure analyses have revealed a dominant role of local disease progression, which has fueled investigations on bridging and early salvage radiation to improve long-term outcomes in patients, particularly those with localized or high-risk disease. Several potential mechanisms by which radiation therapy may improve CAR T efficacy have been proposed that include cytoreduction, tumor debulking, neutralization of immunosuppressive hypoxic and acidic tumor microenvironments, and immunologic and pro-apoptotic synergy between radiation and CAR T. Prospective clinical trials and translational work are ongoing and are needed to inform our conceptual understanding of potential mechanisms by which radiation therapy may improve CAR T efficacy and toxicity, identify which patients may be most likely to benefit, and confirm proposed clinical benefits. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+Large+B-Cell%2c+Diffuse%2fradiotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, Large B-Cell, Diffuse/radiotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+Large+B-Cell%2c+Diffuse%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, Large B-Cell, Diffuse/therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Goyco Vera D</b>, Waghela H, Nuh M, Pan J, Lulla P. Approved CAR-T therapies have reproducible efficacy and safety in clinical practice. <em class='incite-journal-name' onclick='ShowInCiteJournal(10540);'>Hum Vaccin Immunother</em> 2024;<b>20</b>:2378543. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39104200' target='_blank'>39104200</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11305028' target='_blank'>PMC11305028</a> DOI: <a href='https://dx.doi.org/10.1080/21645515.2024.2378543' target='_blank'>10.1080/21645515.2024.2378543</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/21645515.2024.2378543','39104200', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/21645515.2024.2378543' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10540);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/07/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1080/21645515.2024.2378543" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">CAR-T cell therapy has established itself as a highly effective treatment for hematological malignancies. There are currently six commercial CAR-T products that have been FDA approved for diseases such as B-ALL, LBCL, MCL, FL, MM, and CLL/SLL. "Real-world" studies allow us to evaluate outcomes from the general population to determine their efficacy and safety compared to those who were included in the original trials. Based on several well conducted "Real-world" studies that represent diverse populations, we report that outcomes from the original trials that led to the approval of these therapies are comparable to those in practice. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+efficacy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T efficacy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+outcomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T outcomes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+real-world%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T real-world</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+safety%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T safety</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chimeric+antigen+receptor+T-cell+therapy+outcomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chimeric antigen receptor T-cell therapy outcomes</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematologic+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematologic Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+Trials+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical Trials as Topic</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Hori K</b>, Yamada S, Murata K, Miyata H, Mizue Y, Murai A, Minowa T, Sasaki K, Shijubou N, Kubo T, Morita R, Tokita S, Kanaseki T, Tsukahara T, Abe T, Shinohara N, Hirohashi Y, Torigoe T. Establishment of potent TCR-T cells specific for cisplatin-resistance related tumor-associated antigen, CLSPN using codon-optimization. <em class='incite-journal-name' onclick='ShowInCiteJournal(10540);'>Hum Vaccin Immunother</em> 2024;<b>20</b>:2414542. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39539024' target='_blank'>39539024</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572277' target='_blank'>PMC11572277</a> DOI: <a href='https://dx.doi.org/10.1080/21645515.2024.2414542' target='_blank'>10.1080/21645515.2024.2414542</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/21645515.2024.2414542','39539024', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/21645515.2024.2414542' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10540);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1080/21645515.2024.2414542" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Adoptive T cell therapy, using T cell receptor-engineered T (TCR-T) cells and chimeric antigen receptor T (CAR-T) cells, is a potent immunotherapy option. Bladder cancer is a prevalent urological malignancy, particularly in cases of muscle invasion and metastasis, for which systemic therapy is crucial. Immunotherapy utilizing immune checkpoint blockade has been approved for bladder cancer treatment. The antitumor effect of an immune checkpoint blockade based on cytotoxic T cells (CTLs) and the patient's immune status is essential. The chemotherapeutic drug cisplatin (CDDP) is a key drug in bladder cancer treatment. However, it has been shown to suppress T cells, making combination therapy with CDDP and immunotherapy difficult. To address this, we developed TCR-T cells specific for bladder cancer cells. In previous studies, we found that the tumor-associated antigen CLSPN is overexpressed in CDDP-resistant bladder cancer cells and that the antigenic peptide HLA-A*02:01/CLSPN1254-1262, encoded by CLSPN, could be targeted by a CTL clone. The TCR was cloned from the HLA-A*02:01/CLSPN1254-1262 specific CTL clone yc3. We also designed a codon-optimized TCR sequence using GeneArt® GeneOptimizer® (Opt TCR) and compared the TCR-T cells using the original TCR sequence (Ori TCR-T cells) and the codon-optimized TCR sequence (Opt TCR-T cells). Opt TCR-T cells exhibited higher TCR transduction efficiency, higher TCR expression levels, higher avidity, and greater cytotoxicity than did Ori TCR-T cells. These results suggest that HLA-A*02:01/CLSPN1254-1262 specific Opt TCR-T cells are promising candidates for CDDP combination therapy. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CLSPN%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CLSPN</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TCR-T%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TCR-T</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urothelial+carcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urothelial carcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cisplatin+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cisplatin resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunotherapy</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cisplatin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cisplatin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urinary+Bladder+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urinary Bladder Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urinary+Bladder+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urinary Bladder Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urinary+Bladder+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urinary Bladder Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+Neoplasm%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, Neoplasm/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+Neoplasm%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, Neoplasm/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Antigen%2c+T-Cell%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Antigen, T-Cell/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Antigen%2c+T-Cell%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Antigen, T-Cell/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Resistance%2c+Neoplasm%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Resistance, Neoplasm/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2c+Cytotoxic%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes, Cytotoxic/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Codon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Codon</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HLA-A2+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HLA-A2 Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HLA-A2+Antigen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HLA-A2 Antigen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Huang Q</b>, Li H, Zhang Y. A bibliometric and knowledge-map study on the treatment of hematological malignancies with CAR-T cells from 2012 to 2023. <em class='incite-journal-name' onclick='ShowInCiteJournal(10540);'>Hum Vaccin Immunother</em> 2024;<b>20</b>:2371664. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38961667' target='_blank'>38961667</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11225924' target='_blank'>PMC11225924</a> DOI: <a href='https://dx.doi.org/10.1080/21645515.2024.2371664' target='_blank'>10.1080/21645515.2024.2371664</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/21645515.2024.2371664','38961667', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1080/21645515.2024.2371664' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10540);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1080/21645515.2024.2371664" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Recently, CAR-T cell therapy in hematological malignancies has received extensive attention. The objective of this study is to gain a comprehensive understanding of the current research status, development trends, research hotspots, and emerging topics pertaining to CAR-T cells in the treatment of hematological malignancies. Articles pertaining to CAR-T cell therapy for hematological malignancies from the years 2012 to 2023 were obtained and assessed from the Web of Science Core Collection (WoSCC). A bibliometric approach was employed to conduct a scientific, comprehensive, and objective quantitative analysis, as well as a visual analysis, of this particular research domain. A comprehensive analysis was conducted on a corpus of 3643 articles, which were collaboratively authored by 72 countries and various research institutions. CAR-T cell research in treating hematological malignancies shows an increasing trend each year. Notably, the study identified the countries and institutions displaying the highest level of activity, the journals with the most citations and output, as well as the authors who garnered the highest frequency of citations and co-citations. Furthermore, the analysis successfully identified the research hotspots and highlighted six emerging topics within this domain. This study conducted a comprehensive exploration and analysis of the research status, development trends, research hotspots, and emerging topics about CAR-T cells in the treatment of hematological malignancies from 2012 to 2023. The findings of this study will serve as a valuable reference and guide for researchers seeking to delve deeper into this field and determine the future direction of their research. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bibliometric%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bibliometric</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22development+trends%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">development trends</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22emerging+themes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">emerging themes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hematological+malignancies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hematological malignancies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22research+hotspots%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">research hotspots</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematologic+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematologic Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bibliometrics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bibliometrics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Fritz C</b>, Wong DP, Rock P, Burack R, Radhakrishnan A, Parameswaran R. Cell therapy for a rare disease- hairy cell leukemia variant. <em class='incite-journal-name' onclick='ShowInCiteJournal(18379);'>Oncoimmunology</em> 2024;<b>13</b>:2432062. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39604816' target='_blank'>39604816</a> DOI: <a href='https://dx.doi.org/10.1080/2162402x.2024.2432062' target='_blank'>10.1080/2162402x.2024.2432062</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/2162402x.2024.2432062','39604816', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18379);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1080/2162402x.2024.2432062" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Hairy cell leukemia variant (HCL-v) is a rare malignancy of clonal mature B-cells that follows a chronic disease course. HCL-v patients are often resistant to purine nucleoside analogs, which are the first-line therapy. To address the shortcomings of current therapy for HCL-v, we investigated the activity of a BAFF ligand-based CAR-T cell which binds to all three BAFF receptors, BAFF-receptor, TACI, and BCMA. Here, we demonstrate that HCLv patient-derived cells highly express all three BAFF receptors and that BAFF CAR-T cells induce significant cytotoxicity in vitro against both cell lines and HCL-v patient cells. This cytotoxicity corresponds with significant CAR-T cell activation, degranulation, and release of pro-inflammatory cytokines after co-incubation with HCLv cells. Furthermore, we successfully generated BAFF CAR-T cells directly from an HCLv patient and observed direct autologous killing against patient tumor cells in vitro. These HCLv patient-derived CAR-T cells were also effective in killing the Hair-M cell line and tumor cells derived from a different HCLv patient. Lastly, we also developed two mouse xenograft models for HCL, a subcutaneous Bonna-12 model and intravenous Hair-M xenograft model. We observed decreases in tumor burden and prolonged overall survival without significant toxicity. In conclusion, here we show that BAFF CAR-T cells exert anti-tumor effects in vitro and in vivo against multiple cell lines and patient-derived HCL-v samples and may be a successful therapeutic strategy for HCLv patients. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BAFF%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BAFF</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HCL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HCL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cytotoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cytotoxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22leukemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">leukemia</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukemia%2c+Hairy+Cell%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukemia, Hairy Cell/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukemia%2c+Hairy+Cell%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukemia, Hairy Cell/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xenograft+Model+Antitumor+Assays%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xenograft Model Antitumor Assays</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+SCID%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, SCID</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+NOD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred NOD</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Jin MJ</b>, Gao Y, Tian J. A bibliometric and knowledge-map study on the treatment of hematological malignancies with CAR-T cells from 2012 to 2023: A correspondence. <em class='incite-journal-name' onclick='ShowInCiteJournal(10540);'>Hum Vaccin Immunother</em> 2024;<b>20</b>:2386223. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39105681' target='_blank'>39105681</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323137' target='_blank'>PMC11323137</a> DOI: <a href='https://dx.doi.org/10.1080/21645515.2024.2386223' target='_blank'>10.1080/21645515.2024.2386223</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/21645515.2024.2386223','39105681', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/21645515.2024.2386223' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10540);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/07/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1080/21645515.2024.2386223" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematological+malignancies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematological malignancies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bibliometric+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bibliometric analysis</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematologic+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematologic Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bibliometrics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bibliometrics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Baybutt TR</b>, Entezari AA, Caspi A, Staudt RE, Carlson RD, Waldman SA, Snook AE. CD8α Structural Domains Enhance GUCY2C CAR-T Cell Efficacy. <em class='incite-journal-name' onclick='ShowInCiteJournal(4396);'>Cancer Biol Ther</em> 2024;<b>25</b>:2398801. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39315411' target='_blank'>39315411</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423665' target='_blank'>PMC11423665</a> DOI: <a href='https://dx.doi.org/10.1080/15384047.2024.2398801' target='_blank'>10.1080/15384047.2024.2398801</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15384047.2024.2398801','39315411', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(19);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4396);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/25/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1080/15384047.2024.2398801" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Despite success in treating some hematological malignancies, CAR-T cells have not yet produced similar outcomes in solid tumors due, in part, to the tumor microenvironment, poor persistence, and a paucity of suitable target antigens. Importantly, the impact of the CAR components on these challenges remains focused on the intracellular signaling and antigen-binding domains. In contrast, the flexible hinge and transmembrane domains have been commoditized and are the least studied components of the CAR. Here, we compared the hinge and transmembrane domains derived from either the CD8ɑ or CD28 molecule in identical GUCY2C-targeted third-generation designs for colorectal cancer. While these structural domains do not contribute to differences in antigen-independent contexts, such as CAR expression and differentiation and exhaustion phenotypes, the CD8ɑ structural domain CAR has a greater affinity for GUCY2C. This results in increased production of inflammatory cytokines and granzyme B, improved cytolytic effector function with low antigen-expressing tumor cells, and robust anti-tumor efficacy in vivo compared with the CD28 structural domain CAR. This suggests that CD8α structural domains should be considered in the design of all CARs for the generation of high-affinity CARs and optimally effective CAR-T cells in solid tumor immunotherapy. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cell+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cell therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chimeric+antigen+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chimeric antigen receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GUCY2C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GUCY2C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22colorectal+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">colorectal cancer</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD8+Antigens%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD8 Antigens/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD8+Antigens%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD8 Antigens/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Enterotoxin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Enterotoxin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Enterotoxin%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Enterotoxin/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA206026 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T32 CA236736 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R21 CA267087 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NINDS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R21 NS130388 NINDS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R21 CA286339 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAAA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T32 AA007463 NIAAA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDDK+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DK138834 NIDDK NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 CA056036 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Miao L</b>, Zhang J, Xu W, Qian Q, Zhang G, Yuan Q, Lv Y, Zhang H, Shen C, Wang W. Global research trends in CAR-T cell therapy for solid tumors: A comprehensive visualization and bibliometric study (2012-2023). <em class='incite-journal-name' onclick='ShowInCiteJournal(10540);'>Hum Vaccin Immunother</em> 2024;<b>20</b>:2338984. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38698555' target='_blank'>38698555</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073418' target='_blank'>PMC11073418</a> DOI: <a href='https://dx.doi.org/10.1080/21645515.2024.2338984' target='_blank'>10.1080/21645515.2024.2338984</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/21645515.2024.2338984','38698555', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/21645515.2024.2338984' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10540);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1080/21645515.2024.2338984" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">CAR-T cell therapy has emerged as a significant approach for the management of hematological malignancies. Over the past few years, the utilization of CAR-T cells in the investigation and treatment of solid tumors has gained momentum, thereby establishing itself as a prominent area of research. This descriptive study involved the retrieval of articles about CAR-T cell therapy for solid tumors from the Web of Science Core Collection (WoSCC) database. Subsequently, bibliometric analysis and knowledge map analysis were conducted on these articles. The field under consideration is currently experiencing a period of swift advancement, as evidenced by the escalating number of publications in this domain each year. The United States holds an indisputable position as the foremost leader in this particular field, with the University of Pennsylvania emerging as the most active institution. The authors with the highest citation frequency and co-citation frequency are Carl H. June and Shannon L. Maude, respectively. The research hotspots in this field mainly focus on five aspects. Additionally, 10 emerging themes were identified. This study undertakes a comprehensive, systematic, and objective analysis and exploration of the field of CAR-T cell treatment for solid tumors, utilizing bibliometric methods. The findings of this study are expected to serve as a valuable reference and enlightenment for future research endeavors in this particular domain. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bibliometric%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bibliometric</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22emerging+topics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">emerging topics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hotspots%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hotspots</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22knowledge-map%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">knowledge-map</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22solid+tumors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">solid tumors</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bibliometrics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bibliometrics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomedical+Research%2ftrends%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomedical Research/trends</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Li W</b>, Feng J, Peng J, Zhang X, Aziz AUR, Wang D. Chimeric antigen receptor-natural killer (CAR-NK) cell immunotherapy: A bibliometric analysis from 2004 to 2023. <em class='incite-journal-name' onclick='ShowInCiteJournal(10540);'>Hum Vaccin Immunother</em> 2024;<b>20</b>:2415187. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39414236' target='_blank'>39414236</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486046' target='_blank'>PMC11486046</a> DOI: <a href='https://dx.doi.org/10.1080/21645515.2024.2415187' target='_blank'>10.1080/21645515.2024.2415187</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/21645515.2024.2415187','39414236', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/21645515.2024.2415187' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10540);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/18/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1080/21645515.2024.2415187" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Chimeric antigen receptor-natural killer (CAR-NK) cells represent a breakthrough in cancer immunotherapy, making this a highly popular research area. However, comprehensive analyses of this field using bibliometric methods are rare. To our knowledge, this study has collected highest number of publications (1,259) on CAR-NK therapy from January 1, 2004, to December 31, 2023, and utilized CiteSpace and VOSviewer to analyze regions, institutions, journals, authors, and keywords to forecast the latest trends in CAR-NK therapy research. The United States and China, contributing over 60% of publications, are the primary drivers in this field. The Helmholtz Association and Harvard University are the most active institutions, with most publications appearing in Frontiers in Immunology. Winfried S. Wels is the most prolific author, while EL Liu is the most frequently co-cited author. "Immunotherapy," "T-cells," and "Cancer" are the most extensively covered topics in CAR-NK therapy research. Our study reveals current CAR-NK research trends, identifies potential research hotspots, and visualizes references through bibliometric methods, providing valuable guidance for future research in this field. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-NK+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-NK cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bibliometric+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bibliometric analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunotherapy</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bibliometrics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bibliometrics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Killer+Cells%2c+Natural%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Killer Cells, Natural/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2ftrends%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/trends</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22United+States%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">United States</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">China</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Li W</b>, Chen J, Guo Z. Targeting metabolic pathway enhance CAR-T potency for solid tumor. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>143</b>:113412. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39454410' target='_blank'>39454410</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.113412' target='_blank'>10.1016/j.intimp.2024.113412</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.113412','39454410', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.113412' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.intimp.2024.113412" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Chimeric antigen receptor (CAR) T cells have great potential in cancer therapy, particularly in treating hematologic malignancies. However, their efficacy in solid tumors remains limited, with a significant proportion of patients failing to achieve long-term complete remission. One major challenge is the premature exhaustion of CAR-T cells, often due to insufficient metabolic energy. The survival, function and metabolic adaptation of CAR-T cells are key determinants of their therapeutic efficacy. We explore how targeting metabolic pathways in the tumor microenvironment can enhance CAR-T cell therapy by addressing metabolic competition and immunosuppression that impair CAR-T cell function. Tumors undergo metabolically reprogrammed to meet their rapid proliferation, thereby modulating metabolic pathways in immune cells to promote immunosuppression. The distinct metabolic requirements of tumors and T cells create a competitive environment, affecting the efficacy of CAR-T cell therapy. Recent research on glucose, lipid and amino acid metabolism, along with the interactions between tumor and immune cell metabolism, has revealed that targeting these metabolic processes can enhance antitumor immune responses. Combining metabolic interventions with existing antitumor therapies can fulfill the metabolic demands of immune cells, providing new ideas for tumor immunometabolic therapies. This review discusses the latest advances in the immunometabolic mechanisms underlying tumor immunosuppression, their implications for immunotherapy, and summarizes potential metabolic targets to improve the efficacy of CAR-T therapy. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cell+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cell therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolism+reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolism reprogramming</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor microenvironment</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Networks+and+Pathways%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Networks and Pathways</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Kostopoulos N</b>, Costabile F, Krimitza E, Beghi S, Goia D, Perales-Linares R, Thyfronitis G, LaRiviere MJ, Chong EA, Schuster SJ, Maity A, Koumenis C, Plastaras JP, Facciabene A. Local radiation enhances systemic CAR T-cell efficacy by augmenting antigen crosspresentation and T-cell infiltration. <em class='incite-journal-name' onclick='ShowInCiteJournal(3912);'>Blood Adv</em> 2024;<b>8</b>:6308-6320. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39213422' target='_blank'>39213422</a> DOI: <a href='https://dx.doi.org/10.1182/bloodadvances.2024012599' target='_blank'>10.1182/bloodadvances.2024012599</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1182/bloodadvances.2024012599','39213422', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(23);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1182/bloodadvances.2024012599' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3912);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1182/bloodadvances.2024012599" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ABSTRACT</div><div class="abstract-content">Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 (CART-19) represents a significant advance in the treatment of patients with relapsed or refractory CD19+ B-cell lymphomas. However, a significant portion of patients either relapse or fail to respond. Moreover, many patients have symptomatic disease, requiring bridging radiation therapy (RT) during the period of CAR T-cell manufacturing. To investigate the impact of 1 to 2 fractions of low-dose RT on CART-19 treatment response, we developed a mouse model using A20 lymphoma cells for CART-19 therapy. We found that low-dose fractionated RT had a positive effect on generating abscopal systemic antitumor responses beyond the irradiated site. The combination of RT with CART-19 therapy resulted in additive effects on tumor growth in irradiated masses. Notably, a significant additional increase in antitumor effect was observed in nonirradiated tumors. Mechanistically, our results validate activation of the cyclic guanosine adenosine synthetase/stimulator of interferon genes pathway, tumor-associated antigen crosspriming, and elicitation of epitope spreading. Collectively, our findings suggest that RT may serve as an optimal priming and bridging modality for CAR T-cell therapy, overcoming treatment resistance and improving clinical outcomes in patients with CD19+ hematologic malignancies. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+CD19%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, CD19/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+B-Cell%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, B-Cell/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+B-Cell%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, B-Cell/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+B-Cell%2fradiotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, B-Cell/radiotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xenograft+Model+Antitumor+Assays%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xenograft Model Antitumor Assays</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA206012 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Rankin AW</b>, Duncan BB, Allen C, Silbert SK, Shah NN. Evolving strategies for addressing CAR T-cell toxicities. <em class='incite-journal-name' onclick='ShowInCiteJournal(4441);'>Cancer Metastasis Rev</em> 2024;<b>44</b>:17. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39674824' target='_blank'>39674824</a> DOI: <a href='https://dx.doi.org/10.1007/s10555-024-10227-1' target='_blank'>10.1007/s10555-024-10227-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s10555-024-10227-1','39674824', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s10555-024-10227-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4441);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/canc/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/16/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1007/s10555-024-10227-1" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The field of chimeric antigen receptor (CAR) T-cell therapy has grown from a fully experimental concept to now boasting a multitude of treatments including six FDA-approved products targeting various hematologic malignancies. Yet, along with their efficacy, these therapies come with side effects requiring timely and thoughtful interventions. In this review, we discuss the most common toxicities associated with CAR T-cells to date, highlighting risk factors, prognostication, implications for critical care management, patient experience optimization, and ongoing work in the field of toxicity mitigation. Understanding the current state of the field and standards of practice is critical in order to improve and manage potential toxicities of both current and novel CAR T-cell therapies as they are applied in the clinic. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-cell+acute+lymphoblastic+leukemia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-cell acute lymphoblastic leukemia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22B-cell+lymphoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">B-cell lymphoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR+T-cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR T-cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Relapse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Relapse</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Resistance</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematologic+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematologic Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematologic+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematologic Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Antigen%2c+T-Cell%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Antigen, T-Cell/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intramural+Research+Program%2c+Center+of+Cancer+Research%2c+National+Cancer+Institute%2c+National+Institutes+of+Health%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZIA BC 011823 Intramural Research Program, Center of Cancer Research, National Cancer Institute, National Institutes of Health</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Maurer K</b>, Grabski IN, Houot R, Gohil SH, Miura S, Redd R, Lyu H, Lu W, Arihara Y, Budka J, McDonough M, Ansuinelli M, Reynolds C, Jacene H, Li S, Livak KJ, Ritz J, Miles B, Mattie M, Neuberg DS, Irizarry RA, Armand P, Wu CJ, Jacobson C. Baseline immune state and T-cell clonal kinetics are associated with durable response to CAR-T therapy in large B-cell lymphoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(3753);'>Blood</em> 2024;<b>144</b>:2490-2502. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39241199' target='_blank'>39241199</a> DOI: <a href='https://dx.doi.org/10.1182/blood.2024024381' target='_blank'>10.1182/blood.2024024381</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1182/blood.2024024381','39241199', 'Receptors, Chimeric Antigen/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1182/blood.2024024381' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3753);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/08/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1182/blood.2024024381" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ABSTRACT</div><div class="abstract-content">Engineered cellular therapy with CD19-targeting chimeric antigen receptor T cells (CAR-Ts) has revolutionized outcomes for patients with relapsed/refractory large B-cell lymphoma (LBCL), but the cellular and molecular features associated with response remain largely unresolved. We analyzed serial peripheral blood samples ranging from the day of apheresis (day -28/baseline) to 28 days after CAR-T infusion from 50 patients with LBCL treated with axicabtagene ciloleucel by integrating single-cell RNA and T-cell receptor sequencing, flow cytometry, and mass cytometry to characterize features associated with response to CAR-T. Pretreatment patient characteristics associated with response included the presence of B cells and increased absolute lymphocyte count to absolute monocyte count ratio (ALC/AMC). Infusion products from responders were enriched for clonally expanded, highly activated CD8+ T cells. We expanded these observations to 99 patients from the ZUMA-1 cohort and identified a subset of patients with elevated baseline B cells, 80% of whom were complete responders. We integrated B-cell proportion ≥0.5% and ALC/AMC ≥1.2 into a 2-factor predictive model and applied this model to the ZUMA-1 cohort. Estimated progression-free survival at 1 year in patients meeting 1 or both criteria was 65% vs 31% for patients meeting neither criterion. Our results suggest that patients' immunologic state at baseline affects the likelihood of response to CAR-T through both modulation of the T-cell apheresis product composition and promoting a more favorable circulating immune compartment before therapy. These baseline immunologic features, measured readily in the clinical setting before CAR-T, can be applied to predict response to therapy. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+Large+B-Cell%2c+Diffuse%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, Large B-Cell, Diffuse/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphoma%2c+Large+B-Cell%2c+Diffuse%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphoma, Large B-Cell, Diffuse/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biological+Products%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biological Products/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+CD19%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, CD19/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Antigen%2c+T-Cell%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Antigen, T-Cell/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Antigen%2c+T-Cell%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Antigen, T-Cell/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li></ul> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; 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class="cl"></div> </div> </div> </div> <table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="RootHolder_LeftLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Receptors, Chimeric Antigen/immunology (1244 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Receptors, Chimeric Antigen/immunology (1244 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>