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class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Receptori</span> </div> </a> <ul id="toc-Receptori-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Povezano" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Povezano"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Povezano</span> </div> </a> <ul id="toc-Povezano-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Prikaži/sakrij sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Prikaži/sakrij sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading" lang="sh-Latn" dir="ltr"><span class="mw-page-title-main">Antagonist (farmakologija)</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Prijedi na druge jezične varijante članka. Dostupno je na 32 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-32" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">32 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D9%86%D8%A7%D9%87%D8%B6%D8%A9_(%D8%A3%D8%AF%D9%88%D9%8A%D8%A9)" title="مناهضة (أدوية) — Arapski" lang="ar" hreflang="ar" data-title="مناهضة (أدوية)" data-language-autonym="العربية" data-language-local-name="Arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-arz badge-Q17437798 badge-goodarticle mw-list-item" title="dobar članak"><a href="https://arz.wikipedia.org/wiki/%D9%85%D9%86%D8%A7%D9%87%D8%B6_%D8%A7%D9%84%D9%85%D8%B3%D8%AA%D9%82%D8%A8%D9%84" title="مناهض المستقبل — Egyptian Arabic" lang="arz" hreflang="arz" data-title="مناهض المستقبل" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%90%D0%BD%D1%82%D0%B0%D0%B3%D0%BE%D0%BD%D0%B8%D1%81%D1%82_(%D1%84%D0%B0%D1%80%D0%BC%D0%B0%D0%BA%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F)" title="Антагонист (фармакология) — Bugarski" lang="bg" hreflang="bg" data-title="Антагонист (фармакология)" data-language-autonym="Български" data-language-local-name="Bugarski" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Antagonista_(bioqu%C3%ADmica_i_farmacologia)" title="Antagonista (bioquímica i farmacologia) — Katalonski" lang="ca" hreflang="ca" data-title="Antagonista (bioquímica i farmacologia)" data-language-autonym="Català" data-language-local-name="Katalonski" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Antagonist_(Pharmakologie)" title="Antagonist (Pharmakologie) — Nemački" lang="de" hreflang="de" data-title="Antagonist (Pharmakologie)" data-language-autonym="Deutsch" data-language-local-name="Nemački" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en badge-Q17437798 badge-goodarticle mw-list-item" title="dobar članak"><a href="https://en.wikipedia.org/wiki/Receptor_antagonist" title="Receptor antagonist — Engleski" lang="en" hreflang="en" data-title="Receptor antagonist" data-language-autonym="English" data-language-local-name="Engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Antagonista_(bioqu%C3%ADmica)" title="Antagonista (bioquímica) — Španski" lang="es" hreflang="es" data-title="Antagonista (bioquímica)" data-language-autonym="Español" data-language-local-name="Španski" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Antagonist_(farmakoloogia)" title="Antagonist (farmakoloogia) — Estonski" lang="et" hreflang="et" data-title="Antagonist (farmakoloogia)" data-language-autonym="Eesti" data-language-local-name="Estonski" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Antagonista_(biokimika)" title="Antagonista (biokimika) — Baskijski" lang="eu" hreflang="eu" data-title="Antagonista (biokimika)" data-language-autonym="Euskara" data-language-local-name="Baskijski" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A2%D9%86%D8%AA%D8%A7%DA%AF%D9%88%D9%86%DB%8C%D8%B3%D8%AA_%DA%AF%DB%8C%D8%B1%D9%86%D8%AF%D9%87" title="آنتاگونیست گیرنده — Persijski" lang="fa" hreflang="fa" data-title="آنتاگونیست گیرنده" data-language-autonym="فارسی" data-language-local-name="Persijski" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Antagonisti_(l%C3%A4%C3%A4ketiede)" title="Antagonisti (lääketiede) — Finski" lang="fi" hreflang="fi" data-title="Antagonisti (lääketiede)" data-language-autonym="Suomi" data-language-local-name="Finski" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Antagoniste_(biochimie)" title="Antagoniste (biochimie) — Francuski" lang="fr" hreflang="fr" data-title="Antagoniste (biochimie)" data-language-autonym="Français" data-language-local-name="Francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%A0%D7%98%D7%92%D7%95%D7%A0%D7%99%D7%A1%D7%98_(%D7%A4%D7%A8%D7%9E%D7%A7%D7%95%D7%9C%D7%95%D7%92%D7%99%D7%94)" title="אנטגוניסט (פרמקולוגיה) — Hebrejski" lang="he" hreflang="he" data-title="אנטגוניסט (פרמקולוגיה)" data-language-autonym="עברית" data-language-local-name="Hebrejski" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Antagonist_(kemija)" title="Antagonist (kemija) — Hrvatski" lang="hr" hreflang="hr" data-title="Antagonist (kemija)" data-language-autonym="Hrvatski" data-language-local-name="Hrvatski" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Antagonis_reseptor" title="Antagonis reseptor — Indonezijski" lang="id" hreflang="id" data-title="Antagonis reseptor" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonezijski" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-is mw-list-item"><a href="https://is.wikipedia.org/wiki/Vi%C3%B0takahindri" title="Viðtakahindri — Islandski" lang="is" hreflang="is" data-title="Viðtakahindri" data-language-autonym="Íslenska" data-language-local-name="Islandski" class="interlanguage-link-target"><span>Íslenska</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Antagonista_(biochimica)" title="Antagonista (biochimica) — Italijanski" lang="it" hreflang="it" data-title="Antagonista (biochimica)" data-language-autonym="Italiano" data-language-local-name="Italijanski" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E5%8F%97%E5%AE%B9%E4%BD%93%E6%8B%AE%E6%8A%97%E8%96%AC" title="受容体拮抗薬 — Japanski" lang="ja" hreflang="ja" data-title="受容体拮抗薬" data-language-autonym="日本語" data-language-local-name="Japanski" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%88%98%EC%9A%A9%EC%B2%B4_%EA%B8%B8%ED%95%AD%EC%A0%9C" title="수용체 길항제 — Korejski" lang="ko" hreflang="ko" data-title="수용체 길항제" data-language-autonym="한국어" data-language-local-name="Korejski" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Antagonist_(biochemie)" title="Antagonist (biochemie) — Holandski" lang="nl" hreflang="nl" data-title="Antagonist (biochemie)" data-language-autonym="Nederlands" data-language-local-name="Holandski" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Antagonista_(farmakologia)" title="Antagonista (farmakologia) — Poljski" lang="pl" hreflang="pl" data-title="Antagonista (farmakologia)" data-language-autonym="Polski" data-language-local-name="Poljski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Antagonista_(farmacologia)" title="Antagonista (farmacologia) — Portugalski" lang="pt" hreflang="pt" data-title="Antagonista (farmacologia)" data-language-autonym="Português" data-language-local-name="Portugalski" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Antagonist_(farmacologie)" title="Antagonist (farmacologie) — Rumunski" lang="ro" hreflang="ro" data-title="Antagonist (farmacologie)" data-language-autonym="Română" data-language-local-name="Rumunski" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%90%D0%BD%D1%82%D0%B0%D0%B3%D0%BE%D0%BD%D0%B8%D1%81%D1%82_(%D0%B1%D0%B8%D0%BE%D1%85%D0%B8%D0%BC%D0%B8%D1%8F)" title="Антагонист (биохимия) — Ruski" lang="ru" hreflang="ru" data-title="Антагонист (биохимия)" data-language-autonym="Русский" data-language-local-name="Ruski" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Receptor_antagonist" title="Receptor antagonist — Simple English" lang="en-simple" hreflang="en-simple" data-title="Receptor antagonist" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Antagonist_(farmakologija)" title="Antagonist (farmakologija) — Slovenački" lang="sl" hreflang="sl" data-title="Antagonist (farmakologija)" data-language-autonym="Slovenščina" data-language-local-name="Slovenački" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Antagonist_(farmakologija)" title="Antagonist (farmakologija) — Srpski" lang="sr" hreflang="sr" data-title="Antagonist (farmakologija)" data-language-autonym="Српски / srpski" data-language-local-name="Srpski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Antagonist_(farmakologi)" title="Antagonist (farmakologi) — Švedski" lang="sv" hreflang="sv" data-title="Antagonist (farmakologi)" data-language-autonym="Svenska" data-language-local-name="Švedski" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%81%E0%B8%AD%E0%B8%99%E0%B8%95%E0%B8%B2%E0%B9%82%E0%B8%81%E0%B8%99%E0%B8%B4%E0%B8%AA%E0%B8%95%E0%B9%8C" title="แอนตาโกนิสต์ — Tajlandski" lang="th" hreflang="th" data-title="แอนตาโกนิสต์" data-language-autonym="ไทย" data-language-local-name="Tajlandski" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Antagonist_(farmakoloji)" title="Antagonist (farmakoloji) — Turski" lang="tr" hreflang="tr" data-title="Antagonist (farmakoloji)" data-language-autonym="Türkçe" data-language-local-name="Turski" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D0%BD%D1%82%D0%B0%D0%B3%D0%BE%D0%BD%D1%96%D1%81%D1%82_(%D1%84%D0%B0%D1%80%D0%BC%D0%B0%D0%BA%D0%BE%D0%BB%D0%BE%D0%B3%D1%96%D1%8F)" title="Антагоніст (фармакологія) — Ukrajinski" lang="uk" hreflang="uk" data-title="Антагоніст (фармакологія)" data-language-autonym="Українська" data-language-local-name="Ukrajinski" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%8F%97%E4%BD%93%E6%8B%AE%E6%8A%97%E5%89%82" title="受体拮抗剂 — Kineski" lang="zh" hreflang="zh" data-title="受体拮抗剂" data-language-autonym="中文" data-language-local-name="Kineski" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div 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srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Antagonist.sr.png/330px-Antagonist.sr.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Antagonist.sr.png/440px-Antagonist.sr.png 2x" data-file-width="1238" data-file-height="1121" /></a><figcaption>Antagonisti blokiraju vezivanje <a href="/wiki/Agonist" class="mw-redirect" title="Agonist">agonista</a> za molekul <a href="/wiki/Receptor_(biohemija)" title="Receptor (biohemija)">receptor</a>, čime inhibiraju signal koji bi bio proizveden spregom receptora i agonista.</figcaption></figure> <p><b>Antagonist</b> je tip <a href="/wiki/Receptor_(biohemija)" title="Receptor (biohemija)">receptorskog</a> <a href="/wiki/Ligand_(biohemija)" title="Ligand (biohemija)">liganda</a> ili <a href="/wiki/Lek" class="mw-redirect" title="Lek">leka</a> koji ne izaziva biološki respons vezivanjem za <a href="/wiki/Receptor_(biohemija)" title="Receptor (biohemija)">receptor</a>, nego blokira ili prigušuje <a href="/wiki/Agonist_(farmakologija)" title="Agonist (farmakologija)">agonist</a>-posredovani respons.<sup id="cite_ref-pharmguide_1-0" class="reference"><a href="#cite_note-pharmguide-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> U <a href="/wiki/Farmakologija" title="Farmakologija">farmakologiji</a>, <b>antagonisti</b> imaju <a href="/wiki/Konstanta_disocijacije#Protein-ligand_vezivanje" title="Konstanta disocijacije">afinitet</a>, ali ne <a href="/wiki/Efikasnost#Farmakologija" title="Efikasnost">efikasnost</a> za njihove receptore. Njihovo vezivanje onemogućava interakciju i inhibira funkciju <a href="/wiki/Agonist_(farmakologija)" title="Agonist (farmakologija)">agonista</a> ili <a href="/wiki/Inverzni_agonist" title="Inverzni agonist">inverznih agonista</a> na receptorima. Antagonisti dejstvuju putem vezivanja za aktivna mesta, ili za alosterna mesta na receptorima. Oni isto tako mogu da interaguju na mestima vezivanja koja normalno ne učestvuju u biološkoj regulaciji aktivnosti receptora. Aktivnost antagonista može da bude reverziblna ili ireverzibilna u zavisnosti od trajnosti kompleksa antagonista i receptora, što je uslovljeno prirodom veze između antagonista i receptora. Većina lekova koji su antagonisti ostvaruju svoju potentnost konkurišući endogenim ligandima ili supstratima na strukturno-definisanim mestima vezivanja na receptorima.<sup id="cite_ref-pmid12209152_2-0" class="reference"><a href="#cite_note-pmid12209152-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Budući da antagonisti često ometaju normalne veze između neurona, njihova dugoročna, hronična primena je povezana sa smrću neurona, i vrlo jaki antagonisti se mogu smatrati toksičnim<sup id="cite_ref-pmid15756305_3-0" class="reference"><a href="#cite_note-pmid15756305-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Receptori">Receptori</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonist_(farmakologija)&veaction=edit&section=1" title="Uredi odjeljak Receptori" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonist_(farmakologija)&action=edit&section=1" title="Uredi kôd odjeljka Receptori"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <dl><dd><div class="noprint relarticle mainarticle"><i>Glavni članak: <a href="/wiki/Receptor_(biohemija)" title="Receptor (biohemija)">Receptor (biohemija)</a></i></div></dd></dl> <p>Biohemijski <a href="/wiki/Receptor_(biohemija)" title="Receptor (biohemija)">receptori</a> su veliki <a href="/wiki/Protein" title="Protein">proteinski</a> molekuli koji mogu da se aktiviraju vezivanjem <a href="/wiki/Ligand_(biohemija)" title="Ligand (biohemija)">liganda</a> (poput <a href="/wiki/Hormon" class="mw-redirect" title="Hormon">hormona</a> ili <a href="/wiki/Lek" class="mw-redirect" title="Lek">leka</a>).<sup id="cite_ref-2006Kenakin_4-0" class="reference"><a href="#cite_note-2006Kenakin-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Receptori mogu da budu vezani za membranu, da se pojave na membrani ćelija, ili <a href="/wiki/Intracelularni_receptor" title="Intracelularni receptor">intracelularno</a>, na primer na <a href="/wiki/Jedro" title="Jedro">nukleusu</a> ili <a href="/wiki/Mitohondrije" title="Mitohondrije">mitohondrijama</a>. Vezivanje je posledica <a href="/wiki/Nekovalentno_vezivanje" title="Nekovalentno vezivanje">nekovalentnih</a> interakcija na <a href="/wiki/Mesto_vezivanja" title="Mesto vezivanja">mestima vezivanja</a> na receptoru između receptora i njegovih liganda. Receptor može da sadrži jedno ili više mesta vezivanja za različite ligande. Vezivanje za <a href="/wiki/Aktivno_mesto" class="mw-redirect" title="Aktivno mesto">aktivno mesto</a> na receptoru direktno reguliše aktivaciju receptora.<sup id="cite_ref-2006Kenakin_4-1" class="reference"><a href="#cite_note-2006Kenakin-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Aktivnost receptora takođe može biti <a href="/wiki/Alosterna_regulacija" title="Alosterna regulacija">regulisana</a> vezivanjem liganda na druga mesta na receptoru, poput alosternih mesta vezivanja.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Antagonisti dejstvuju putem sprečavanja agonist-indukovanih responsa receptora. To se može postići vezivanjem za aktivno mesto ili za alosterno mesto.<sup id="cite_ref-Christopoulos_6-0" class="reference"><a href="#cite_note-Christopoulos-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Sem toga, antagonisti mogu da interaguju na mestima koja normalno ne učestvuju u biološkoj regulaciji aktivnosti receptora.<sup id="cite_ref-Christopoulos_6-1" class="reference"><a href="#cite_note-Christopoulos-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Termin <i>antagonist</i> je bio originalno korišten za opisivanje različitih profila efekata leka.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Biohemijsku definiciju antagonista receptora su uveli Ariens<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> i Stefenson<sup id="cite_ref-stephanson_11-0" class="reference"><a href="#cite_note-stephanson-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> <a href="/wiki/1950e" class="mw-redirect" title="1950e">1950-tih</a>. Današnja definicija agonista receptora je bazirana na <a href="/wiki/Teorija_receptora#Priroda_receptor-lek_interakcija" title="Teorija receptora">modelu popunjenosti receptora</a>. To sužava definiciju antagonizma na samo ona jedinjenja koja imaju suprotne aktivnosti na jednom receptoru. Za agoniste se smatra da uključuju pojedinačni ćelijski respons vezivanjem za receptor, i da tako iniciraju biohemijski mehanizam promena u ćeliji. Antagonist isključuju taj respons blokiranjem receptora. Ova definicija je takođe u upotrebi za <a href="/wiki/Fiziolo%C5%A1ki_agonizam_i_antagonizam" title="Fiziološki agonizam i antagonizam">fiziološke antagoniste</a>, supstance koje imaju suprotne fiziološke efekte, ali dejstvuju na različite receptore. Na primer, <a href="/wiki/Histamin" title="Histamin">histamin</a> snižava arterijski pritisak putem <a href="/w/index.php?title=Vazodilacija&action=edit&redlink=1" class="new" title="Vazodilacija (stranica ne postoji)">vazodilacije</a> dejstvujući na <a href="/wiki/Histaminski_H1_receptor" title="Histaminski H1 receptor">histaminski H<sub>1</sub> receptor</a>, dok <a href="/wiki/Adrenalin" title="Adrenalin">adrenalin</a> povišava arterijski pritisak vasokonstrikcijom posredovanom aktivacijom <a href="/wiki/Beta-adrenergi%C4%8Dki_receptor" class="mw-redirect" title="Beta-adrenergički receptor">β-adrenergičkog receptora</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Povezano">Povezano</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonist_(farmakologija)&veaction=edit&section=2" title="Uredi odjeljak Povezano" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonist_(farmakologija)&action=edit&section=2" title="Uredi kôd odjeljka Povezano"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/w/index.php?title=Receptorska_teorija&action=edit&redlink=1" class="new" title="Receptorska teorija (stranica ne postoji)">Receptorska teorija</a></li> <li><a href="/wiki/Agonist_(farmakologija)" title="Agonist (farmakologija)">Agonist</a></li> <li><a href="/wiki/Inhibicija_enzimskih_reakcija" title="Inhibicija enzimskih reakcija">Inhibicija enzimskih reakcija</a></li> <li><a href="/wiki/Efikasnost#Farmakologija" title="Efikasnost">Efikasnost</a></li> <li><a href="/wiki/Konstanta_disocijacije#Protein-ligand_vezivanje" title="Konstanta disocijacije">Afinitet</a></li> <li><a href="/wiki/Inverzni_agonist" title="Inverzni agonist">Inverzni agonist</a></li> <li><a href="/w/index.php?title=Selektivni_modulator_receptora&action=edit&redlink=1" class="new" title="Selektivni modulator receptora (stranica ne postoji)">Selektivni modulator receptora</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonist_(farmakologija)&veaction=edit&section=3" title="Uredi odjeljak Reference" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonist_(farmakologija)&action=edit&section=3" title="Uredi kôd odjeljka Reference"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r41556849">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-pharmguide-1"><span class="mw-cite-backlink"><a href="#cite_ref-pharmguide_1-0">↑</a></span> <span class="reference-text"><span class="citation web"><a href="/wiki/GlaksoSmitKlajn" class="mw-redirect" title="GlaksoSmitKlajn">GlaxoWellcome</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190726074523/http://www.pdg.cnb.uam.es/cursos/Barcelona2002/pages/Farmac/Comput_Lab/Guia_Glaxo/chap2c.html">„Pharmacology Guide: In vitro pharmacology: concentration-response curves”</a>. Arhivirano iz <a rel="nofollow" class="external text" href="http://www.pdg.cnb.uam.es/cursos/Barcelona2002/pages/Farmac/Comput_Lab/Guia_Glaxo/chap2c.html">originala</a> na datum 2019-07-26<span class="reference-accessdate">. Pristupljeno 2014-03-20</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Pharmacology+Guide%3A+In+vitro+pharmacology%3A+concentration-response+curves&rft.atitle=&rft.aulast=%5B%5BGlaksoSmitKlajn%7CGlaxoWellcome%5D%5D&rft.au=%5B%5BGlaksoSmitKlajn%7CGlaxoWellcome%5D%5D&rft_id=https%3A%2F%2Fweb.archive.org%2Fweb%2F20190726074523%2Fhttp%3A%2F%2Fwww.pdg.cnb.uam.es%2Fcursos%2FBarcelona2002%2Fpages%2FFarmac%2FComput_Lab%2FGuia_Glaxo%2Fchap2c.html&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-pmid12209152-2"><span class="mw-cite-backlink"><a href="#cite_ref-pmid12209152_2-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Hopkins AL, Groom CR (2002). „The druggable genome”. <i>Nature reviews. Drug discovery</i> <b>1</b> (9): 727–30. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fnrd892">10.1038/nrd892</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12209152">12209152</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+druggable+genome&rft.jtitle=Nature+reviews.+Drug+discovery&rft.aulast=Hopkins+AL%2C+Groom+CR&rft.au=Hopkins+AL%2C+Groom+CR&rft.date=2002&rft.volume=1&rft.issue=9&rft.pages=727%E2%80%9330&rft_id=info:doi/10.1038%2Fnrd892&rft_id=info:pmid/12209152&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-pmid15756305-3"><span class="mw-cite-backlink"><a href="#cite_ref-pmid15756305_3-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Dorph-Petersen KA, Pierri JN, Perel JM, Sun Z, Sampson AR, Lewis DA (September 2005). <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038/sj.npp.1300710">„The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys”</a>. <i>Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology</i> <b>30</b> (9): 1649–61. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fsj.npp.1300710">10.1038/sj.npp.1300710</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15756305">15756305</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+influence+of+chronic+exposure+to+antipsychotic+medications+on+brain+size+before+and+after+tissue+fixation%3A+a+comparison+of+haloperidol+and+olanzapine+in+macaque+monkeys&rft.jtitle=Neuropsychopharmacology+%3A+Official+Publication+of+the+American+College+of+Neuropsychopharmacology&rft.aulast=Dorph-Petersen+KA%2C+Pierri+JN%2C+Perel+JM%2C+Sun+Z%2C+Sampson+AR%2C+Lewis+DA&rft.au=Dorph-Petersen+KA%2C+Pierri+JN%2C+Perel+JM%2C+Sun+Z%2C+Sampson+AR%2C+Lewis+DA&rft.date=September+2005&rft.volume=30&rft.issue=9&rft.pages=1649%E2%80%9361&rft_id=info:doi/10.1038%2Fsj.npp.1300710&rft_id=info:pmid/15756305&rft_id=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fsj.npp.1300710&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-2006Kenakin-4"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-2006Kenakin_4-0">4,0</a></sup> <sup><a href="#cite_ref-2006Kenakin_4-1">4,1</a></sup></span> <span class="reference-text"><span class="citation book">Kenakin, Terrence P.; Kenakin, Terry (2006). <a rel="nofollow" class="external text" href="https://archive.org/details/pharmacologyprim0002kena"><i>A pharmacology primer: theory, application, and methods</i></a>. Amsterdam: Elsevier/Academic Press. <a href="/wiki/International_Standard_Book_Number" class="mw-redirect" title="International Standard Book Number">ISBN</a> <a href="/wiki/Posebno:Tra%C5%BEi_ISBN/0-12-370599-1" title="Posebno:Traži ISBN/0-12-370599-1">0-12-370599-1</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=A+pharmacology+primer%3A+theory%2C+application%2C+and+methods&rft.aulast=Kenakin%2C+Terrence+P.%3B+Kenakin%2C+Terry&rft.au=Kenakin%2C+Terrence+P.%3B+Kenakin%2C+Terry&rft.date=2006&rft.place=Amsterdam&rft.pub=Elsevier%2FAcademic+Press&rft.isbn=0-12-370599-1&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fpharmacologyprim0002kena&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text"><span class="citation Journal">May LT, Avlani VA, Sexton PM, Christopoulos A (2004). „Allosteric modulation of G protein-coupled receptors”. <i>Curr. Pharm. Des.</i> <b>10</b> (17): 2003–13. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.2174%2F1381612043384303">10.2174/1381612043384303</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15279541">15279541</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Allosteric+modulation+of+G+protein-coupled+receptors&rft.jtitle=Curr.+Pharm.+Des.&rft.aulast=May+LT%2C+Avlani+VA%2C+Sexton+PM%2C+Christopoulos+A&rft.au=May+LT%2C+Avlani+VA%2C+Sexton+PM%2C+Christopoulos+A&rft.date=2004&rft.volume=10&rft.issue=17&rft.pages=2003%E2%80%9313&rft_id=info:doi/10.2174%2F1381612043384303&rft_id=info:pmid/15279541&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Christopoulos-6"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Christopoulos_6-0">6,0</a></sup> <sup><a href="#cite_ref-Christopoulos_6-1">6,1</a></sup></span> <span class="reference-text"><span class="citation Journal">Christopoulos A (2002). „Allosteric binding sites on cell-surface receptors: novel targets for drug discovery”. <i>Nature reviews. Drug discovery</i> <b>1</b> (3): 198–210. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fnrd746">10.1038/nrd746</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12120504">12120504</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Allosteric+binding+sites+on+cell-surface+receptors%3A+novel+targets+for+drug+discovery&rft.jtitle=Nature+reviews.+Drug+discovery&rft.aulast=Christopoulos+A&rft.au=Christopoulos+A&rft.date=2002&rft.volume=1&rft.issue=3&rft.pages=198%E2%80%93210&rft_id=info:doi/10.1038%2Fnrd746&rft_id=info:pmid/12120504&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text"><span class="citation Journal">Bleicher KH, Green LG, Martin RE, Rogers-Evans M (2004). „Ligand identification for G-protein-coupled receptors: a lead generation perspective”. <i>Curr Opin Chem Biol</i> <b>8</b> (3): 287–96. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.cbpa.2004.04.008">10.1016/j.cbpa.2004.04.008</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15183327">15183327</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Ligand+identification+for+G-protein-coupled+receptors%3A+a+lead+generation+perspective&rft.jtitle=Curr+Opin+Chem+Biol&rft.aulast=Bleicher+KH%2C+Green+LG%2C+Martin+RE%2C+Rogers-Evans+M&rft.au=Bleicher+KH%2C+Green+LG%2C+Martin+RE%2C+Rogers-Evans+M&rft.date=2004&rft.volume=8&rft.issue=3&rft.pages=287%E2%80%9396&rft_id=info:doi/10.1016%2Fj.cbpa.2004.04.008&rft_id=info:pmid/15183327&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text"><span class="citation Journal">Rees S, Morrow D, Kenakin T (2002). „GPCR drug discovery through the exploitation of allosteric drug binding sites”. <i>Recept. Channels</i> <b>8</b> (5-6): 261–8. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1080%2F10606820214640">10.1080/10606820214640</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12690954">12690954</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=GPCR+drug+discovery+through+the+exploitation+of+allosteric+drug+binding+sites&rft.jtitle=Recept.+Channels&rft.aulast=Rees+S%2C+Morrow+D%2C+Kenakin+T&rft.au=Rees+S%2C+Morrow+D%2C+Kenakin+T&rft.date=2002&rft.volume=8&rft.issue=5-6&rft.pages=261%E2%80%938&rft_id=info:doi/10.1080%2F10606820214640&rft_id=info:pmid/12690954&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text"><span class="citation Journal">Negus SS (2006). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC1866283/">„Some implications of receptor theory for in vivo assessment of agonists, antagonists and inverse agonists”</a>. <i>Biochem. Pharmacol.</i> <b>71</b> (12): 1663–70. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.bcp.2005.12.038">10.1016/j.bcp.2005.12.038</a>. <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC1866283">1866283</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/16460689">16460689</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Some+implications+of+receptor+theory+for+in+vivo+assessment+of+agonists%2C+antagonists+and+inverse+agonists&rft.jtitle=Biochem.+Pharmacol.&rft.aulast=Negus+SS&rft.au=Negus+SS&rft.date=2006&rft.volume=71&rft.issue=12&rft.pages=1663%E2%80%9370&rft_id=info:doi/10.1016%2Fj.bcp.2005.12.038&rft_id=info:pmc/1866283&rft_id=info:pmid/16460689&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1866283%2F&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><a href="#cite_ref-10">↑</a></span> <span class="reference-text"><span class="citation Journal">Ariëns EJ (1954). „Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory”. <i>Archives internationales de pharmacodynamie et de thérapie</i> <b>99</b> (1): 32–49. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/13229418">13229418</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Affinity+and+intrinsic+activity+in+the+theory+of+competitive+inhibition.+I.+Problems+and+theory&rft.jtitle=Archives+internationales+de+pharmacodynamie+et+de+th%C3%A9rapie&rft.aulast=Ari%C3%ABns+EJ&rft.au=Ari%C3%ABns+EJ&rft.date=1954&rft.volume=99&rft.issue=1&rft.pages=32%E2%80%9349&rft_id=info:pmid/13229418&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-stephanson-11"><span class="mw-cite-backlink"><a href="#cite_ref-stephanson_11-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Stephenson RP (1997). „A modification of receptor theory. 1956”. <i>Br. J. Pharmacol.</i> <b>120</b> (4 Suppl): 106–20; discussion 103–5. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/9142399">9142399</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+modification+of+receptor+theory.+1956&rft.jtitle=Br.+J.+Pharmacol.&rft.aulast=Stephenson+RP&rft.au=Stephenson+RP&rft.date=1997&rft.volume=120&rft.issue=4+Suppl&rft.pages=106%E2%80%9320%3B+discussion+103%E2%80%935&rft_id=info:pmid/9142399&rfr_id=info:sid/en.wikipedia.org:Antagonist_(farmakologija)"><span style="display: none;"> </span></span> <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510558/">1510558</a> of the original article.</span> </li> </ol></div> <div class="navbox-styles nomobile"><style 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title="Razgovor o šablonu:Farmakologija-lat"><abbr title="Razgovarajte o šablonu" style=";background:#efefef;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">r</abbr></a></li><li class="nv-uredi"><a class="external text" href="https://sh.wikipedia.org/w/index.php?title=%C5%A0ablon:Farmakologija-lat&action=edit"><abbr title="Uredite šablon" style=";background:#efefef;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">u</abbr></a></li></ul></div><div id="Farmakološki_koncepti" style="font-size:114%;margin:0 4em"><a href="/wiki/Farmakologija" title="Farmakologija">Farmakološki</a> <a href="/wiki/Lek" class="mw-redirect" title="Lek">koncepti</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Farmakokinetika" title="Farmakokinetika">Farmakokinetika</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/ADME" title="ADME">ADME</a>: <a href="/wiki/Apsorpcija_(farmakokinetika)" title="Apsorpcija (farmakokinetika)">Apsorpcija</a> •  <a href="/wiki/Distribucija_(farmakologija)" title="Distribucija (farmakologija)">Distribucija</a> •  <a href="/wiki/Metabolizam_leka" class="mw-redirect" title="Metabolizam leka">Metabolizam</a> •  <a href="/wiki/Ekskrecija" class="mw-redirect" title="Ekskrecija">Ekskrecija</a> (<a href="/wiki/Uklanjanje_(medicina)" class="mw-redirect" title="Uklanjanje (medicina)">Uklanjanje</a>) <p><a href="/wiki/Po%C4%8Detna_doza" title="Početna doza">Početna doza</a> •  <a href="/wiki/Volumen_distribucije" title="Volumen distribucije">Volumen distribucije</a> (<a href="/wiki/Inicijalni_volumen_raspodele" class="mw-redirect" title="Inicijalni volumen raspodele">Inicijalni</a>) •  <a href="/wiki/Stopa_infuzije" title="Stopa infuzije">Stopa infuzije</a> </p><p><a href="/wiki/Pregrada_(farmakokinetika)" title="Pregrada (farmakokinetika)">Pregrada</a> •  <a href="/wiki/Bioekvivalentnost" title="Bioekvivalentnost">Bioekvivalentnost</a> •  <a href="/wiki/Bioraspolo%C5%BEivost" title="Bioraspoloživost">Biodostupnost</a> </p><p><a href="/wiki/Po%C4%8Detak_dejstva" title="Početak dejstva">Početak dejstva</a> •  <a href="/wiki/Poluvreme_eliminacije" title="Poluvreme eliminacije">Biološki polu-život</a> •  <a href="/wiki/Vezivanje_za_proteine_plazme" title="Vezivanje za proteine plazme">Vezivanje za proteine plazme</a> </p> <a href="/wiki/Terapeutski_indeks" title="Terapeutski indeks">Terapeutski indeks</a> (<a href="/wiki/Letalna_doza" class="mw-redirect" title="Letalna doza">LD<sub>50</sub></a>/<a href="/wiki/Efektivna_doza" title="Efektivna doza">ED<sub>50</sub></a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Farmakodinamika" title="Farmakodinamika">Farmakodinamika</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Toksi%C4%8Dnost" title="Toksičnost">Toksičnost</a> (<a href="/wiki/Neurotoksikologija" class="mw-redirect" title="Neurotoksikologija">Neurotoksikologija</a>) •  <a href="/wiki/Odnos_doza-efekat" class="mw-redirect" title="Odnos doza-efekat">Odnos doza-efekat</a> (<a href="/wiki/Efikasnost#Farmakologija" title="Efikasnost">Efikasnost</a>, <a href="/wiki/Potentnost_(farmakologija)" title="Potentnost (farmakologija)">Potentnost</a>)<br /> <a href="/wiki/Antimikrobna_farmakodinamika" title="Antimikrobna farmakodinamika">Antimikrobna farmakodinamika</a>: <a href="/wiki/Minimalna_inhibitorna_koncentracija" title="Minimalna inhibitorna koncentracija">Minimalna inhibitorna koncentracija</a>/<a href="/wiki/Bakteriostati%C4%8Dki_agens" title="Bakteriostatički agens">Bakteriostatik</a> •  <a href="/wiki/Minimalna_baktericidna_koncentracija" title="Minimalna baktericidna koncentracija">Minimalna baktericidna koncentracija</a>/<a href="/wiki/Baktericid" title="Baktericid">Baktericid</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Agonizam i antagonizam</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Agonist_(farmakologija)" title="Agonist (farmakologija)">Agonist</a>: <a href="/wiki/Inverzni_agonist" title="Inverzni agonist">Inverzni agonist</a> •  <a href="/wiki/Ireverzibilni_agonist" title="Ireverzibilni agonist">Ireverzibilni agonist</a> •  <a href="/wiki/Parcijalni_agonist" title="Parcijalni agonist">Parcijalni agonist</a> •  <a href="/wiki/Superagonist" title="Superagonist">Superagonist</a> •  <a href="/wiki/Fiziolo%C5%A1ki_agonizam_i_antagonizam" title="Fiziološki agonizam i antagonizam">Fiziološki agonist</a><br /> <p><a class="mw-selflink selflink">Antagonist</a>: <a href="/wiki/Kompetitivni_antagonist" title="Kompetitivni antagonist">Konkurentni antagonist</a> •  <a href="/wiki/Ireverzibilni_antagonist" title="Ireverzibilni antagonist">Ireverzibilni antagonist</a> •  <a href="/wiki/Fiziolo%C5%A1ki_agonizam_i_antagonizam" title="Fiziološki agonizam i antagonizam">Fiziološki antagonist</a> </p> Drugo: <a href="/wiki/Vezivanje_(molekulsko)" class="mw-redirect" title="Vezivanje (molekulsko)">Vezivanje</a> •  <a href="/wiki/Konstanta_disocijacije#Protein-ligand_vezivanje" title="Konstanta disocijacije">Afinitet</a> •  <a href="/wiki/Selektivnost_vezivanja" title="Selektivnost vezivanja">Selektivnost vezivanja</a> •  <a href="/wiki/Funkcionalna_selektivnost" title="Funkcionalna selektivnost">Funkcionalna selektivnost</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Drugo</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Tolerancija_leka" title="Tolerancija leka">Tolerancija leka</a>: <a href="/wiki/Tahifilaksija" title="Tahifilaksija">Tahifilaksija</a><br /> <a href="/wiki/Otpornost_na_lek" title="Otpornost na lek">Otpornost na lek</a>: <a href="/wiki/Otpornost_na_antibiotik" class="mw-redirect" title="Otpornost na antibiotik">Otpornost na antibiotik</a> •  <a href="/wiki/Otpornost_na_vi%C5%A1estruke_lekove" title="Otpornost na višestruke lekove">Otpornost na višestruke lekove</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Srodna polja/podpolja</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Farmakogenetika" title="Farmakogenetika">Farmakogenetika</a> •  <a href="/wiki/Farmakogenomika" title="Farmakogenomika">Farmakogenomika</a> •  <a href="/wiki/Neuropsihofarmakologija" title="Neuropsihofarmakologija">Neuropsihofarmakologija</a> (<a href="/wiki/Neurofarmakologija" title="Neurofarmakologija">Neurofarmakologija</a>, <a href="/wiki/Psihofarmakologija" title="Psihofarmakologija">Psihofarmakologija</a>)</div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="" lang="sh-Latn" dir="ltr">Izvor: <a dir="ltr" href="https://sh.wikipedia.org/w/index.php?title=Antagonist_(farmakologija)&oldid=42169637">https://sh.wikipedia.org/w/index.php?title=Antagonist_(farmakologija)&oldid=42169637</a></div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Posebno:Kategorije" title="Posebno:Kategorije">Kategorije</a>: <ul><li><a href="/wiki/Kategorija:Antagonisti_receptora" title="Kategorija:Antagonisti receptora">Antagonisti receptora</a></li><li><a href="/wiki/Kategorija:Transdukcija_signala" title="Kategorija:Transdukcija signala">Transdukcija signala</a></li><li><a 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