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class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Mohd Riyaz Beg" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/114829104/27715599/37931778/s200_mohd_riyaz.beg.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Mohd Riyaz Beg</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://ictmumbai.academia.edu/">Institute of Chemical Technology, Mumbai</a>, <a class="u-tcGrayDarker" href="https://ictmumbai.academia.edu/Departments/Department_of_Pharmaceutical_Science_and_Technology/Documents">Department of Pharmaceutical Science and Technology</a>, <span class="u-tcGrayDarker">Graduate Student</span></div><div><a class="u-tcGrayDarker" href="https://ankitkumar.academia.edu/">Jamia Hamdard, New Delhi</a>, <a class="u-tcGrayDarker" href="https://ankitkumar.academia.edu/Departments/Faculty_of_Pharmacy/Documents">Faculty of Pharmacy</a>, <span class="u-tcGrayDarker">Undergraduate</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Mohd Riyaz" data-follow-user-id="114829104" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="114829104"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">589</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">25</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/MohdRiyazBeg/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Mr. Beg is a Research Scholar at the Institute of Chemical Technology, Mumbai. He loves to write and review articles related to pharmacology, natural products and pharmaceutics. He has in-hand experience in Quality control, Quality assurance, and Production in Pharmaceutical industry. Recently, he is associated with Global Product Compliance Group, Sweden as a Research Trainee on a project related to Cosmetics Regulations.  Earlier he has completed his summer training and studies in Clinical and Hospital Pharmacy. He is also working on a Project: Antibiotics Utilization in hospitals under the guidance of Dr. Zeenat Iqbal, SPER, Jamia Hamdard. <br />Mr. Beg leading a pupil's community named as Pharmacy Community: Hamdard. His research interests includes Pharmacology, Pharmaceutics, Biochemical aspect of diseases, and Herbal products<br /><span class="u-fw700">Supervisors: </span>Prof. Sadhana Sathaye, Dr. Zeenat Iqbal, Dr. Mohd Aqil, and Prof. K. S. Laddha<br /><span class="u-fw700">Phone: </span>7838966006<br /><b>Address: </b>SS Pharmacology Lab, Dept. of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, 400019, Maharashtra, India<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/JosephOrgel"><img class="profile-avatar u-positionAbsolute" alt="Joseph Orgel" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/39262543/Types_of_errors_in_Pharmaceutical_analysis"><img alt="Research paper thumbnail of Types of errors in Pharmaceutical analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/59396561/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/39262543/Types_of_errors_in_Pharmaceutical_analysis">Types of errors in Pharmaceutical analysis</a></div><div class="wp-workCard_item"><span> Errors in Pharmaceutical analysis</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Errors in the pharmaceutical analysis are very common but it is the responsibility of the analyst...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Errors in the pharmaceutical analysis are very common but it is the responsibility of the analyst to understand the causes of errors and take necessary precautions to avoid such errors. In the given text I tried to showcase the possible errors in Pharmaceutical analysis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="235fb40679f25cd2f1ee6bc679913d28" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":59396561,"asset_id":39262543,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/59396561/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="39262543"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="39262543"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 39262543; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="39262389"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/39262389/Pharmaceuticals_Evaluation"><img alt="Research paper thumbnail of Pharmaceuticals Evaluation" class="work-thumbnail" src="https://attachments.academia-assets.com/59396385/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/39262389/Pharmaceuticals_Evaluation">Pharmaceuticals Evaluation</a></div><div class="wp-workCard_item"><span>Solid Dosage form Evaluation</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In-process quality control (IPQC) tests was important to remove problems from every stage in prod...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In-process quality control (IPQC) tests was important to remove problems from every stage in production and maintain the quality of the In-process product with standards as specified in the pharmacopoeias. The quality of FP depends on in-process control (IPC) tests because it helps to incorporate excellence within the products. The qualitative and quantitative parameters of pharmaceuticals or biopharmaceuticals products was checked by In-process quality control (IPQC). The aim of this investigation was to provide concise information on the IPQC and FPQC (finished products quality control) tests for pharmaceutical solid dosage as per different pharmacopoeias.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ac6832a022a561ab91785a7827d7b2e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":59396385,"asset_id":39262389,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/59396385/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="39262389"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="39262389"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 39262389; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=39262389]").text(description); $(".js-view-count[data-work-id=39262389]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 39262389; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='39262389']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7ac6832a022a561ab91785a7827d7b2e" } } $('.js-work-strip[data-work-id=39262389]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":39262389,"title":"Pharmaceuticals Evaluation","internal_url":"https://www.academia.edu/39262389/Pharmaceuticals_Evaluation","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[{"id":59396385,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/59396385/thumbnails/1.jpg","file_name":"evaluation_parameters_of_Solid_dosage_forms20190526-66880-139wcal.pdf","download_url":"https://www.academia.edu/attachments/59396385/download_file","bulk_download_file_name":"Pharmaceuticals_Evaluation.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/59396385/evaluation_parameters_of_Solid_dosage_forms20190526-66880-139wcal-libre.pdf?1558861358=\u0026response-content-disposition=attachment%3B+filename%3DPharmaceuticals_Evaluation.pdf\u0026Expires=1739797934\u0026Signature=FvyeWSnMBxEqbH~JzHTHof83TyLbuFR2Nosfht5V2hzwC1ZYVo28tmJ31Walz4o4wcvWVGRmpPE7ZncBJvKp24~K5df19hPad9I~t-iicut7evISeTMGbqWMnLnrxBM8-QEOAC6h7DwCNIt7Faafwg-pKIe1vF5M0LBoGMD3CIH50Nd3TUqyNLb5PQxVs-dA5LKcQsz14qpETVnd~IXJ1MYRwq2PR2KAw7NlU~4cHRczkpPGLfqE05cHL68xyju-He7jSPoYJQKM-yy3uJB~Ac8vvF00VT6bQdR593Vo21mSRItlQaaiUvaGofIHepzMFvEpV1SWMSj-RXplVvc2KA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="profile--tab_heading_container js-section-heading" data-section="Conference Presentations" id="Conference Presentations"><h3 class="profile--tab_heading_container">Conference Presentations by Mohd Riyaz Beg</h3></div><div class="js-work-strip profile--work_container" data-work-id="44610464"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/44610464/Covid_challenge_Mohd_Riyaz_Beg"><img alt="Research paper thumbnail of Covid challenge Mohd Riyaz Beg" class="work-thumbnail" src="https://attachments.academia-assets.com/65075146/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/44610464/Covid_challenge_Mohd_Riyaz_Beg">Covid challenge Mohd Riyaz Beg</a></div><div class="wp-workCard_item"><span>D. Y. Patil College of Pharmacy</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A novel approach to improve the bioavailability of Ashwagandha Bioactives.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b3a5996a963727a3cfce01b103c08eba" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65075146,"asset_id":44610464,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65075146/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="44610464"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="44610464"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 44610464; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=44610464]").text(description); $(".js-view-count[data-work-id=44610464]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 44610464; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='44610464']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b3a5996a963727a3cfce01b103c08eba" } } $('.js-work-strip[data-work-id=44610464]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":44610464,"title":"Covid challenge Mohd Riyaz Beg","internal_url":"https://www.academia.edu/44610464/Covid_challenge_Mohd_Riyaz_Beg","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[{"id":65075146,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/65075146/thumbnails/1.jpg","file_name":"Covid_challenge_Mohd_Riyaz_Beg.pdf","download_url":"https://www.academia.edu/attachments/65075146/download_file","bulk_download_file_name":"Covid_challenge_Mohd_Riyaz_Beg.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/65075146/Covid_challenge_Mohd_Riyaz_Beg-libre.pdf?1606815667=\u0026response-content-disposition=attachment%3B+filename%3DCovid_challenge_Mohd_Riyaz_Beg.pdf\u0026Expires=1739797934\u0026Signature=Z36UmccwKNRnCgrFRQFDkfB7xOFnote3QNIKmPPZrwRD6S66vRfVbrWcKaR~jAtYkqSPniKX1qiLnoGVdZg326r5mg1m6vjBA6j582xvfrEo6UtWeHdTu48lVJyMGUUg3Sf1-aTUz2Nrx0aAXdlM-wcWp4WNssqXV9EG-W3-brzEpJzMrPXoNm~nLNo6bNJKZcB0zt0H-LKf9IjfFOUazHbJN-pwYQocOE1JjWE5RV7AiYPQ6dO78PJ60v~rEcKNOKsmeVQL1dHWfTIh1ImpHgGaCWh6i2ySSlyxwQO6Fc6bKwd0YMjok5kmnKP4PBuH6subwCX2Pb42TYAie49cpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="profile--tab_heading_container js-section-heading" data-section="Drafts" id="Drafts"><h3 class="profile--tab_heading_container">Drafts by Mohd Riyaz Beg</h3></div><div class="js-work-strip profile--work_container" data-work-id="45590572"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45590572/Access_to_medicines_Fundamental_human_right"><img alt="Research paper thumbnail of Access to medicines: Fundamental human right" class="work-thumbnail" src="https://attachments.academia-assets.com/66070664/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45590572/Access_to_medicines_Fundamental_human_right">Access to medicines: Fundamental human right</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c2dd2de17b5318a23c7aab997c29624e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66070664,"asset_id":45590572,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66070664/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45590572"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45590572"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45590572; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Mohd Riyaz Beg</h3></div><div class="js-work-strip profile--work_container" data-work-id="105891590"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891590/Organotin_Antifouling_Compounds_and_Sex_Steroid_Nuclear_Receptor_Perturbation_Some_Structural_Insights"><img alt="Research paper thumbnail of Organotin Antifouling Compounds and Sex-Steroid Nuclear Receptor Perturbation: Some Structural Insights" class="work-thumbnail" src="https://attachments.academia-assets.com/105235173/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891590/Organotin_Antifouling_Compounds_and_Sex_Steroid_Nuclear_Receptor_Perturbation_Some_Structural_Insights">Organotin Antifouling Compounds and Sex-Steroid Nuclear Receptor Perturbation: Some Structural Insights</a></div><div class="wp-workCard_item"><span>Toxics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Organotin compounds (OTCs) are a commercially important group of organometallic compounds of tin ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Organotin compounds (OTCs) are a commercially important group of organometallic compounds of tin used globally as polyvinyl chloride stabilizers and marine antifouling biocides. Worldwide use of OTCs has resulted in their ubiquitous presence in ecosystems across all the continents. OTCs have metabolic and endocrine disrupting effects in marine and terrestrial organisms. Thus, harmful OTCs (tributyltin) have been banned by the International Convention on the Control of Harmful Antifouling Systems since 2008. However, continued manufacturing by non-member countries poses a substantial risk for animal and human health. In this study, structural binding of common commercial OTCs, tributyltin (TBT), dibutyltin (DBT), monobutyltin (MBT), triphenyltin (TPT), diphenyltin (DPT), monophenyltin (MPT), and azocyclotin (ACT) against sex-steroid nuclear receptors, androgen receptor (AR), and estrogen receptors (ERα, ERβ) was performed using molecular docking and MD simulation. TBT, DBT, DPT, and ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cc3b7b67026ef7a22c48f2d581b1ea36" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235173,"asset_id":105891590,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235173/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891590"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891590"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891590; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cc3b7b67026ef7a22c48f2d581b1ea36" } } $('.js-work-strip[data-work-id=105891590]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105891590,"title":"Organotin Antifouling Compounds and Sex-Steroid Nuclear Receptor Perturbation: Some Structural Insights","internal_url":"https://www.academia.edu/105891590/Organotin_Antifouling_Compounds_and_Sex_Steroid_Nuclear_Receptor_Perturbation_Some_Structural_Insights","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[{"id":105235173,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105235173/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/105235173/download_file","bulk_download_file_name":"Organotin_Antifouling_Compounds_and_Sex.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105235173/pdf-libre.pdf?1692824017=\u0026response-content-disposition=attachment%3B+filename%3DOrganotin_Antifouling_Compounds_and_Sex.pdf\u0026Expires=1739710025\u0026Signature=hIqpqM7kkMq8at3RMTc2qm53AQbafLFWDC3s04xrlheqBhJVYBs1FBBoa3nHFmRJJkg8s9Jns275N1~AsR8rYd8mK2m06zwn45n4Yqtmi73l9l0wtl5-RdxVJ6Lt8ATnl6Nt4S2Sb5iXSPycL5jhRXo3X4xXliNSNvKc8JatRg3xhaR42ooCGNgTCR~WbtuvJpAEYCdf1X96i83TaK8DWpbfwoTeFdDZNCz3WdvMatco22SjxlZrfMEuOGA23RqZaqzpAJoK1oQ2RzsyNcsHP57IUVqiXmpkOFKue2WXt3~ctVCK6x0Wg2UAXvnBlTeSVjnTr42hPo75RFaZmxqcJA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":105235172,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105235172/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/105235172/download_file","bulk_download_file_name":"Organotin_Antifouling_Compounds_and_Sex.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105235172/pdf-libre.pdf?1692824029=\u0026response-content-disposition=attachment%3B+filename%3DOrganotin_Antifouling_Compounds_and_Sex.pdf\u0026Expires=1739710025\u0026Signature=I62feKg4FGcGz5hgalXAMWSJzSX5QQxJ~DQgIZQwgE6ETlspJNuMKX8xBV3vE00qloijPJg2lCg9~~hpy4jeSbt6VMOQzdTQ0-acqdn1X~qkcsyilu3~ExS1oEvjTGoNbV-JjL9zmoEN2Kl~nh0IMmA7mn9gAlkNHBHpzVhFv5S8C8i9wk9RHf~olZ9sHGXw94X9nM9ceIFBKlsUqV0TMTMwi-Y6lQga3ypENhfmIRFcCqLZRI~JZ4iHT8jZT0oGDZ4l0hquG1DS110x4zi5Z080ZNNKRixh0lXh6q2nqt9cUcqxU7vdwnoyTz4rVEHXvhgj1XtVFemlibhlNxgevA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891589"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891589/Potential_Disruption_of_Systemic_Hormone_Transport_by_Tobacco_Alkaloids_Using_Computational_Approaches"><img alt="Research paper thumbnail of Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches" class="work-thumbnail" src="https://attachments.academia-assets.com/105235174/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891589/Potential_Disruption_of_Systemic_Hormone_Transport_by_Tobacco_Alkaloids_Using_Computational_Approaches">Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches</a></div><div class="wp-workCard_item"><span>Toxics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tobacco/nicotine is one of the most toxic and addictive substances and continues to pose a signif...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tobacco/nicotine is one of the most toxic and addictive substances and continues to pose a significant threat to global public health. The harmful effects of smoking/nicotine affect every system in the human body. Nicotine has been associated with effects on endocrine homeostasis in humans such as the imbalance of gonadal steroid hormones, adrenal corticosteroid hormones, and thyroid hormones. The present study was conducted to characterize the structural binding interactions of nicotine and its three important metabolites, cotinine, trans-3′-hydroxycotinine, and 5′-hydroxycotinine, against circulatory hormone carrier proteins, i.e., sex-hormone-binding globulin (SHBG), corticosteroid-binding globulin (CBG), and thyroxine-binding globulin (TBG). Nicotine and its metabolites formed nonbonded contacts and/or hydrogen bonds with amino acid residues of the carrier proteins. For SHBG, Phe-67 and Met-139 were the most important amino acid residues for nicotine ligand binding showing the m...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="820ca0c061eac678c15f07bab8a6ac3c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235174,"asset_id":105891589,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235174/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891589"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891589"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891589; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891589]").text(description); $(".js-view-count[data-work-id=105891589]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891589; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891589']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "820ca0c061eac678c15f07bab8a6ac3c" } } $('.js-work-strip[data-work-id=105891589]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105891589,"title":"Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches","internal_url":"https://www.academia.edu/105891589/Potential_Disruption_of_Systemic_Hormone_Transport_by_Tobacco_Alkaloids_Using_Computational_Approaches","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[{"id":105235174,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/105235174/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/105235174/download_file","bulk_download_file_name":"Potential_Disruption_of_Systemic_Hormone.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/105235174/pdf-libre.pdf?1692824042=\u0026response-content-disposition=attachment%3B+filename%3DPotential_Disruption_of_Systemic_Hormone.pdf\u0026Expires=1739797934\u0026Signature=Q0mBcf9qa3llNpZ35xhpMyDTjIhwkZMHKvNeRhmJkfNjHQO3R8nCFqhnCKRlB3Ojwik2HbT~Qtn4-bGO2OC-SA8G9lVl5iNJ22O~5bd~fVg35LuupqC58WtzasK5jsmY-CDNxzUKWrmEsJHRRsYvmNntZzNXz8O~OPfNEI4nGB~CHiEuasyruA7pxFkrQVM9cuvHLxvbRAAnoUKQ2mbDzEb6s~fyU5QsFKTgJLyrRptsEsm-d6AdnCHOtOcFoxjD7ylBM5~o4WWNHh47ZFrthz-~TextdPkDmtJdjDeOlFC-3iRg91LJBpkThFFBNpFfEy0yBouHOxPRgMbWpxE-7w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891588"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891588/Insights_into_the_Endocrine_Disrupting_Activity_of_Emerging_Non_Phthalate_Alternate_Plasticizers_against_Thyroid_Hormone_Receptor_A_Structural_Perspective"><img alt="Research paper thumbnail of Insights into the Endocrine Disrupting Activity of Emerging Non-Phthalate Alternate Plasticizers against Thyroid Hormone Receptor: A Structural Perspective" class="work-thumbnail" src="https://attachments.academia-assets.com/105235171/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891588/Insights_into_the_Endocrine_Disrupting_Activity_of_Emerging_Non_Phthalate_Alternate_Plasticizers_against_Thyroid_Hormone_Receptor_A_Structural_Perspective">Insights into the Endocrine Disrupting Activity of Emerging Non-Phthalate Alternate Plasticizers against Thyroid Hormone Receptor: A Structural Perspective</a></div><div class="wp-workCard_item"><span>Toxics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Many endocrine-disrupting chemicals (EDCs) have a ubiquitous presence in our environment due to a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Many endocrine-disrupting chemicals (EDCs) have a ubiquitous presence in our environment due to anthropogenic activity. These EDCs can disrupt hormone signaling in the human and animal body systems including the very important hypothalamic-pituitary-thyroid (HPT) axis causing adverse health effects. Thyroxine (T4) and triiodothyronine (T3) are hormones of the HPT axis which are essential for regulation of metabolism, heart rate, body temperature, growth, development, etc. In this study, potential endocrine-disrupting activity of the most common phthalate plasticizer, DEHP, and emerging non-phthalate alternate plasticizers, DINCH, ATBC, and DEHA against thyroid hormone receptor (TRα) were characterized. The structural binding characterization of indicated ligands was performed against the TRα ligand binding site employing Schrodinger’s induced fit docking (IFD) approach. The molecular simulations of interactions of the ligands against the residues lining a TRα binding pocket, includi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef5d3a82a960d3e8286fd26b215f91e2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235171,"asset_id":105891588,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235171/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891588"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891588"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891588; 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(DOCX 17Â kb)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891587"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891587"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891587; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891587]").text(description); $(".js-view-count[data-work-id=105891587]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891587; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891587']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105891587]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105891587,"title":"Additional file 1: Table S1. of Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update","internal_url":"https://www.academia.edu/105891587/Additional_file_1_Table_S1_of_Spontaneous_preterm_birth_and_single_nucleotide_gene_polymorphisms_a_recent_update","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891586"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891586/Endocrine_Disruption_Structural_Interactions_of_Androgen_Receptor_against_Di_2_ethylhexyl_Phthalate_and_Its_Metabolites"><img alt="Research paper thumbnail of Endocrine Disruption: Structural Interactions of Androgen Receptor against Di(2-ethylhexyl) Phthalate and Its Metabolites" class="work-thumbnail" src="https://attachments.academia-assets.com/105235169/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891586/Endocrine_Disruption_Structural_Interactions_of_Androgen_Receptor_against_Di_2_ethylhexyl_Phthalate_and_Its_Metabolites">Endocrine Disruption: Structural Interactions of Androgen Receptor against Di(2-ethylhexyl) Phthalate and Its Metabolites</a></div><div class="wp-workCard_item"><span>Toxics</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Diethylhexyl phthalate (DEHP) is a commonly used plasticizer in the manufacture of polyvinyl chlo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Diethylhexyl phthalate (DEHP) is a commonly used plasticizer in the manufacture of polyvinyl chloride plastics for household and commercial use. DEHP is a ubiquitous ecocontaminant and causes developmental and reproductive problems in children and adults. After exposure, DEHP is metabolized by endogenous hydrolysis and oxidation into the primary metabolite, mono-(2-ethylhexyl) phthalate (MEHP), and the secondary metabolites, mono-(2-ethyl-5-hydroxhexyl)phthalate (5-OH-MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (5-oxo-MEHP), mono-(2-ethyl-5-carboxypentyl) phthalate (5-cx-MEPP), and mono-[(2-carboxymethyl)hexyl] phthalate (2-cx-MMHP). Very few studies have been reported on the adverse effects of DEHP metabolites, and the available information indicates that the metabolites might also be equally or more active as compared to the parent compound. In the present study, induced fit docking was used for structural binding characterization of the above five DEHP metabolites with androgen re...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd67bd9ba6917e10ef3ead1de405dd30" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235169,"asset_id":105891586,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235169/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891586"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891586"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891586; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891585"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891585/Plant_Mediated_Green_Synthesis_of_Zinc_Oxide_Nanoparticles_Using_Swertia_chirayita_Leaf_Extract_Characterization_and_Its_Antibacterial_Efficacy_Against_Some_Common_Pathogenic_Bacteria"><img alt="Research paper thumbnail of Plant-Mediated Green Synthesis of Zinc Oxide Nanoparticles Using Swertia chirayita Leaf Extract, Characterization and Its Antibacterial Efficacy Against Some Common Pathogenic Bacteria" class="work-thumbnail" src="https://attachments.academia-assets.com/105235190/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891585/Plant_Mediated_Green_Synthesis_of_Zinc_Oxide_Nanoparticles_Using_Swertia_chirayita_Leaf_Extract_Characterization_and_Its_Antibacterial_Efficacy_Against_Some_Common_Pathogenic_Bacteria">Plant-Mediated Green Synthesis of Zinc Oxide Nanoparticles Using Swertia chirayita Leaf Extract, Characterization and Its Antibacterial Efficacy Against Some Common Pathogenic Bacteria</a></div><div class="wp-workCard_item"><span>BioNanoScience</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The use of plant materials for the green synthesis of zinc oxide nanoparticles has enormous appli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The use of plant materials for the green synthesis of zinc oxide nanoparticles has enormous applications in pharmaceuticals, biotechnological, and biological fields. In this paper, we report Swertia chirayita leaf extract-mediated green synthesis of zinc oxide nanoparticles (ZnONPs). Furthermore, the as-prepared ZnONPs were characterized by employing Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), UV-visible spectroscopy (UV-VIS), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), and energy-dispersive x-ray spectroscopy (EDS). The antibacterial efficacy of green synthesized ZnONPs was investigated against Gram-positive (Staphylococcus aureus) as well as Gramnegative (Escherichia coli and Salmonella enterica) bacterial strains. The efficacy of Swertia chirayita-extracted ZnONPs were found to be effective against Gram-positive as well as Gram-negative bacterial strains, suggesting its plausible use in cases of resistant bacterial infections.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3a623c13cfee121d40e303b214ff82d7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235190,"asset_id":105891585,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235190/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891585"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891585"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891585; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891584"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/105891584/Structural_studies_on_inhibitory_mechanisms_of_antibiotic_corticosteroid_and_catecholamine_molecules_on_lactoperoxidase"><img alt="Research paper thumbnail of Structural studies on inhibitory mechanisms of antibiotic, corticosteroid and catecholamine molecules on lactoperoxidase" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/105891584/Structural_studies_on_inhibitory_mechanisms_of_antibiotic_corticosteroid_and_catecholamine_molecules_on_lactoperoxidase">Structural studies on inhibitory mechanisms of antibiotic, corticosteroid and catecholamine molecules on lactoperoxidase</a></div><div class="wp-workCard_item"><span>Life sciences</span><span>, Jan 15, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lactoperoxidase (LPO) is an essential protein with broad spectrum antimicrobial activity present ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lactoperoxidase (LPO) is an essential protein with broad spectrum antimicrobial activity present in mammalian milk. It imparts immunity to infants against wide range of pathogenic infections. Several in vitro studies have shown inhibition of LPO activity by pharmaceutical compounds including commonly used antibiotics such as ampicillin and gentamicin, and molecules like prednisolone, norepinephrine, etc. Prescription of such drugs to lactating mothers might have adverse health effects on infants. The aim of our study was the elucidation of the structural aspects of the inhibitory mechanism of ampicillin, gentamicin, amoxicillin, prednisolone and norepinephrine on LPO. Three dimensional structure of camel LPO (cLPO) was developed using homology modeling and used for in silico experimental studies. The Schrödinger induced fit docking along with binding affinity estimation experiments were performed. The cLPO and Ligands were prepared using Protein Preparation Wizard and Ligprep module...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891584]").text(description); $(".js-view-count[data-work-id=105891584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105891584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105891584,"title":"Structural studies on inhibitory mechanisms of antibiotic, corticosteroid and catecholamine molecules on lactoperoxidase","internal_url":"https://www.academia.edu/105891584/Structural_studies_on_inhibitory_mechanisms_of_antibiotic_corticosteroid_and_catecholamine_molecules_on_lactoperoxidase","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891583"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/105891583/Molecular_Interactions_of_Bexarotene_A_Retinoid_Drug_And_Alzheimers_A%CE%B2_Peptide_A_Docking_Study"><img alt="Research paper thumbnail of Molecular Interactions of Bexarotene - A Retinoid Drug And Alzheimer's Aβ Peptide: A Docking Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/105891583/Molecular_Interactions_of_Bexarotene_A_Retinoid_Drug_And_Alzheimers_A%CE%B2_Peptide_A_Docking_Study">Molecular Interactions of Bexarotene - A Retinoid Drug And Alzheimer's Aβ Peptide: A Docking Study</a></div><div class="wp-workCard_item"><span>Current Alzheimer research</span><span>, Jan 14, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alzheimer&#039;s disease (AD) pathogenesis is primarily hallmarked by the production and accumula...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alzheimer&#039;s disease (AD) pathogenesis is primarily hallmarked by the production and accumulation of amyloid beta (Aβ) peptide. Along with the understanding of the neurodegenerative disease progression and its pathophysiological mechanisms, development of anti-Aβ targeted effective therapeutics is essential for AD management. Numerous therapeutic approaches targeting the production, toxicity and removal of Aβ are being attempted worldwide. Prime need is to design inhibitors which can slow down the Aβ aggregation process in a physiological environment. Bexarotene (targretin) is the first of the U.S. Food and Drug Administration approved oral retinoid X receptors (RXR)-selective retinoids, or rexinoids. It is effectively used for the treatment of advanced, refractory cutaneous T cell lymphoma, and also reportedly reduces Aβ levels in AD mouse models. Administration of bexarotene facilitates intracellular Aβ clearance via RXR regulated apolipoprotein E (ApoE) production. To the bes...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891583"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891583"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891583; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891583]").text(description); $(".js-view-count[data-work-id=105891583]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891583; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891583']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="105891582"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891582/Development_of_Polymeric_Nanopaclitaxel_and_Comparison_with_Free_Paclitaxel_for_Effects_on_Cell_Proliferation_of_MCF_7_and_B16F0_Carcinoma_Cells"><img alt="Research paper thumbnail of Development of Polymeric Nanopaclitaxel and Comparison with Free Paclitaxel for Effects on Cell Proliferation of MCF-7 and B16F0 Carcinoma Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/105235166/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891582/Development_of_Polymeric_Nanopaclitaxel_and_Comparison_with_Free_Paclitaxel_for_Effects_on_Cell_Proliferation_of_MCF_7_and_B16F0_Carcinoma_Cells">Development of Polymeric Nanopaclitaxel and Comparison with Free Paclitaxel for Effects on Cell Proliferation of MCF-7 and B16F0 Carcinoma Cells</a></div><div class="wp-workCard_item"><span>Asian Pacific Journal of Cancer Prevention</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing adverse effects in normal body sites. In this study, we developed a polymeric nano drug carrier for safe delivery of the paclitaxel to the cancer that releases the drug in a sustained manner and reduces side effects. N-isopropylacrylamide/ vinyl pyrrolidone (NIPAAm/VP) nanoparticles were synthesized by radical polymerization. Physicochemical characterization of the polymeric nanoparticles was conducted using dynamic light scattering, transmission electron microscopy, scanning electron microscopy and nuclear magnetic resonance, which confirmedpolymerization of formulated nanoparticles. Drug release was assessed using a spectrophotometer and cell viability assays were carried out on the MCF-7 breast cancer and B16F0 skin cancer cell lines. NIPAAm/ VP nanoparticles demonstrated a size distribution in the 65-108 nm range and surface charge measured-15.4 mV. SEM showed the nanoparticles to be spherical in shape with a slow drug release of ~70% in PBS at 38°C over 96 h. Drug loaded nanoparticles were associated with increased viability of MCF-7 and B16F0 cells in comparison to free paclitaxel. Nano loaded paclitaxel shows high therapeutic efficiency by sustained release action for the longer period of time, i increasing its efficacy and biocompatibility for human cancer therapy. Therefore, paclitaxel loaded (NIPAAm/VP) nanoparticles may provide opportunities to expand delivery of the drug for clinical selection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d837050667f52d5b7d3f2f082736a78" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235166,"asset_id":105891582,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235166/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891582"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891582"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891582; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891581/Peroxisome_Proliferator_activated_Receptors_as_Potential_Targets_for_Carcinogenic_Activity_of_Polychlorinated_Biphenyls_A_Computational_Perspective"><img alt="Research paper thumbnail of Peroxisome Proliferator-activated Receptors as Potential Targets for Carcinogenic Activity of Polychlorinated Biphenyls: A Computational Perspective" class="work-thumbnail" src="https://attachments.academia-assets.com/105235189/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891581/Peroxisome_Proliferator_activated_Receptors_as_Potential_Targets_for_Carcinogenic_Activity_of_Polychlorinated_Biphenyls_A_Computational_Perspective">Peroxisome Proliferator-activated Receptors as Potential Targets for Carcinogenic Activity of Polychlorinated Biphenyls: A Computational Perspective</a></div><div class="wp-workCard_item"><span>Anticancer Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic chemicals that have been associated with increased risk of hepatic cancer, melanoma, non-Hodgkin lymphoma and cancer of many other body organs. Structural binding analyses of PCB 77 and PCB 118 with peroxisome proliferator-activated receptors (PPARα, PPARβ/δ and PPARγ) was performed to predict the association of PCBs with potential disruption of PPAR signaling pathways. Materials and Methods: The crystal structures of human PPARα, PPARβ/δ and PPARγ were obtained from the Protein Data Bank. Structures of PCB 77 and PCB 118 were obtained from PubChem database. Docking was performed using glide (Schrodinger) induced fit docking (IFD) module. Results: The PCB 77 and PCB 118 interacted with PPARα, PPARβ/δ and PPARγ showing an overlapping of 40-58% interacting amino acid residues with synthetic co-complex agonists of the three PPARs. The binding affinity was higher for PCB 118 than for PCB 77 during docking interactions with each of the three PPARs. Conclusion: The consistent commonality of interacting residues for PCB 77 and PCB 118 with cocomplex synthetic agonists of the PPARs together with good binding affinity suggested that the PPAR signaling pathway is a potential target for toxicologic activity of PCBs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5b850fdb8bd771eb11ede0791fc2f98b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235189,"asset_id":105891581,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235189/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891581; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891581]").text(description); $(".js-view-count[data-work-id=105891581]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891581; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891581']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891579"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891579/Human_sex_hormone_binding_globulin_as_a_potential_target_of_alternate_plasticizers_an_in_silico_study"><img alt="Research paper thumbnail of Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study" class="work-thumbnail" src="https://attachments.academia-assets.com/105235160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891579/Human_sex_hormone_binding_globulin_as_a_potential_target_of_alternate_plasticizers_an_in_silico_study">Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study</a></div><div class="wp-workCard_item"><span>BMC Structural Biology</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Currently, alternate plasticizers are used to replace phthalate plasticizers in child...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Currently, alternate plasticizers are used to replace phthalate plasticizers in children's toys, medical equipments and food packaging, due to the adverse effects of phthalate compounds on human health and laws prohibiting their use. Current information regarding the safety and potential adverse effects of alternate plasticizers is limited and recent studies have found alternate plasticizers to display similar characteristics to those observed in phthalate plasticizers. This study was undertaken to evaluate and predict the potential endocrine disrupting activity of the three most commonly used alternate plasticizers: di(2-ethylhexyl)terephthalate (DEHT), tris(2-ethylhexyl) trimellitate (TOTM), and diisononyl hexahydrophthalate (DINCH) against human sex hormone-binding globulin (SHBG) using in silico approaches. Materials and methods: The crystal structure of human SHBG (Id: 1D2S) was retrieved from Protein Data Bank. PubChem database was searched for the structures of alternate plasticizers, DEHT, TOTM, and DINCH. Docking was performed using Glide (Schrodinger) Induced Fit Docking module. Results: Induced Fit Docking of three alternate plasticizer compounds indicated that each of the three compounds fitted well into the steroid binding pocket of SHBG. Docking displays showed interactions of alternate plasticizers with 25-30 amino-acid residues of SHBG; 18-20 amino residues overlapped between the natural ligand, DHT, and the three compounds (commonality of 82-91 %). The hydrogen-bonding interaction of the amino-acid residue, Asn-82, of SHBG was also present in displays of DHT and all the three alternate phthalates. The binding affinity of all the three alternate phthalates was higher than DHT; maximum in DINCH followed by TOTM and DEHT. Conclusion: Our results suggested that the three alternate plasticizers have potential to engage the important interacting residues of SHBG and thus interfere in its steroid homeostatic function.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ced612b65cf17b4f9c04b2ebe2effb43" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235160,"asset_id":105891579,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235160/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891579"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891579"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891579; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891578"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891578/Abstracts_from_the_3rd_International_Genomic_Medicine_Conference_3rd_IGMC_2015_"><img alt="Research paper thumbnail of Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)" class="work-thumbnail" src="https://attachments.academia-assets.com/105235158/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891578/Abstracts_from_the_3rd_International_Genomic_Medicine_Conference_3rd_IGMC_2015_">Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)</a></div><div class="wp-workCard_item"><span>BMC Genomics</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The ends of linear chromosomes are called telomeres that resemble broken DNA. However, the telome...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The ends of linear chromosomes are called telomeres that resemble broken DNA. However, the telomeres are protected from the DNA damage responses due to the formation of a looping structure (Tloop) and by "capping" the telomeres with a series of shelterin proteins. It is generally thought the main, if not only, function of telomeres is protection from DNA damage responses. When telomeres get very short due to normal replicative aging, cells stop dividing due to loss of the telomere end protective functions. We have previously reported that telomeres may also have additional functions in human cells. Telomeres are characterized by a distinct chromatin structure with spreading of heterochromatin into the subtelomeric regions, but little is known about the chromatin conformation of human telomeres. We have previously shown, using a luciferase reporter introduced into telomeres, that there is a 10-fold decreased expression of the reporter compared to the reporter introduced into internal genomic loci. This phenomenon is known as Telomere Position Effects (TPE). We have also found that a human gene, interferon stimulating gene 15 (ISG15), (~1 M base pairs from the 1p36.33 telomere) is silenced in young cells with long telomerase, upregulated in cells with short telomeres and silenced again in old cells with experimentally hTERT (telomerase) elongated telomeres. However, we observed genes between ISG15 and the telomere are not regulated by classic telomere position effects (TPE). To distinguish this type of telomere length dependent regulation of gene expression from classic TPE, we have termed this type of regulation Telomere Position Effects Over Long Distances (TPE-OLD). We discovered using 3D co-FISH and a modification of Hi-C (chromosome capture followed by high-throughput sequencing), that there are a significant number of genes within the first 10 M bases distal to the telomere on many chromosomes regulated by telomere length with genes closer to the telomere not being regulated by TPE. O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="502bcdfd57484df284122e8cdb166af5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235158,"asset_id":105891578,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235158/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891578"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891578"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891578; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891577"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/105891577/Cold_abcess_neck_with_horner_s_syndrome_a_rare_entity"><img alt="Research paper thumbnail of Cold abcess neck with horner’s syndrome—a rare entity" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/105891577/Cold_abcess_neck_with_horner_s_syndrome_a_rare_entity">Cold abcess neck with horner’s syndrome—a rare entity</a></div><div class="wp-workCard_item"><span>Indian Journal of Thoracic and Cardiovascular Surgery</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891577"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891577"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891577; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105891577]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105891577,"title":"Cold abcess neck with horner’s syndrome—a rare entity","internal_url":"https://www.academia.edu/105891577/Cold_abcess_neck_with_horner_s_syndrome_a_rare_entity","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891576"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891576/Meet_In_The_Middle_Attack_A_Cryptanalysis_Approach"><img alt="Research paper thumbnail of Meet In The Middle Attack: A Cryptanalysis Approach" class="work-thumbnail" src="https://attachments.academia-assets.com/105235187/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891576/Meet_In_The_Middle_Attack_A_Cryptanalysis_Approach">Meet In The Middle Attack: A Cryptanalysis Approach</a></div><div class="wp-workCard_item"><span>International Journal of Computer Applications</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sometimes the information, which is transferred during the communication, is very much confidenti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sometimes the information, which is transferred during the communication, is very much confidential which is needed to be secure. For securing the information various encryption algorithms like DES, BLOWFISH, RC4 etc., are used. Our aim in this paper are to find the two keys using cryptanalysis method, that is used for encrypting the information transferred during communication by using the Meet in the Middle Attack on triple S-DES algorithm, instead of using Brute force attack.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4c4b02674480ae3a050ae681c19abebe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235187,"asset_id":105891576,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235187/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891576"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891576"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891576; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891575"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891575/Energy_efficient_sensor_network_security_using_Stream_cipher_mode_of_operation"><img alt="Research paper thumbnail of Energy efficient sensor network security using Stream cipher mode of operation" class="work-thumbnail" src="https://attachments.academia-assets.com/105235186/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891575/Energy_efficient_sensor_network_security_using_Stream_cipher_mode_of_operation">Energy efficient sensor network security using Stream cipher mode of operation</a></div><div class="wp-workCard_item"><span>2010 International Conference on Computer and Communication Technology (ICCCT)</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sometimes the information, which is transferred during the communication in between sensor node, ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sometimes the information, which is transferred during the communication in between sensor node, is very much confidential which is needed to be secure. Since sensor nodes are resource constrained and run on battery, energy consumption should be low to make it operate for many days. For securing the information various symmetric key encryption algorithms like DES, BLOWFISH, RC4 etc., are used. Our aim in this paper is to apply security in sensor network in such a way that it provide confidentiality with authentication using Stream cipher modes of operation, so that the energy consumption will minimizes at the sensor node and the life time of sensor node will increase.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c725cb76e90fafae31cc1ce894edd2fa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235186,"asset_id":105891575,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235186/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891575"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891575"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891575; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891574"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891574/Computational_Insights_into_the_Inhibitory_Mechanism_of_Human_AKT1_by_an_Orally_Active_Inhibitor_MK_2206"><img alt="Research paper thumbnail of Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206" class="work-thumbnail" src="https://attachments.academia-assets.com/105235192/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891574/Computational_Insights_into_the_Inhibitory_Mechanism_of_Human_AKT1_by_an_Orally_Active_Inhibitor_MK_2206">Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206</a></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The AKT signaling pathway has been identified as an important target for cancer therapy. Among sm...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The AKT signaling pathway has been identified as an important target for cancer therapy. Among small-molecule inhibitors of AKT that have shown tremendous potential in inhibiting cancer, MK-2206 is a highly potent, selective and orally active allosteric inhibitor. Promising preclinical anticancer results have led to entry of MK-2206 into Phase I/II clinical trials. Despite such importance, the exact binding mechanism and the molecular interactions of MK-2206 with human AKT are not available. The current study investigated the exact binding mode and the molecular interactions of MK-2206 with human AKT isoforms using molecular docking and (un)binding simulation analyses. The study also involved the docking analyses of the structural analogs of MK-2206 to AKT1 and proposed one as better inhibitor. The Dock was used for docking simulations of MK-2206 into the allosteric site of AKT isoforms. The Ligplot+ was used for analyses of polar and hydrophobic interactions between AKT isoforms and the ligands. The MoMa-LigPath web server was used to simulate the ligand (un)binding from the binding site to the surface of the protein. In the docking and (un)binding simulation analyses of MK-2206 with human AKT1, the Trp-80 was the key residue and showed highest decrease in the solvent accessibility, highest number of hydrophobic interactions, and the most consistent involvement in all (un)binding simulation phases. The number of molecular interactions identified and calculated binding energies and dissociation constants from the co-complex structures of these isoforms, clearly explained the varying affinity of MK-2206 towards these isoforms. The (un)binding simulation analyses identified various additional residues which despite being away from the binding site, play important role in initial binding of the ligand. Thus, the docking and (un)binding simulation analyses of MK-2206 with AKT isoforms and its structure analogs will provide a suitable model for studying drug-protein interaction and will help in designing better drugs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e3548c64abce4026abfc97a1f4845ddf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235192,"asset_id":105891574,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235192/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891574"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891574"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891574; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="9241019" id="teachingdocuments"><div class="js-work-strip profile--work_container" data-work-id="39262543"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/39262543/Types_of_errors_in_Pharmaceutical_analysis"><img alt="Research paper thumbnail of Types of errors in Pharmaceutical analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/59396561/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/39262543/Types_of_errors_in_Pharmaceutical_analysis">Types of errors in Pharmaceutical analysis</a></div><div class="wp-workCard_item"><span> Errors in Pharmaceutical analysis</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Errors in the pharmaceutical analysis are very common but it is the responsibility of the analyst...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Errors in the pharmaceutical analysis are very common but it is the responsibility of the analyst to understand the causes of errors and take necessary precautions to avoid such errors. In the given text I tried to showcase the possible errors in Pharmaceutical analysis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="235fb40679f25cd2f1ee6bc679913d28" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":59396561,"asset_id":39262543,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/59396561/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="39262543"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="39262543"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 39262543; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="39262389"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/39262389/Pharmaceuticals_Evaluation"><img alt="Research paper thumbnail of Pharmaceuticals Evaluation" class="work-thumbnail" src="https://attachments.academia-assets.com/59396385/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/39262389/Pharmaceuticals_Evaluation">Pharmaceuticals Evaluation</a></div><div class="wp-workCard_item"><span>Solid Dosage form Evaluation</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In-process quality control (IPQC) tests was important to remove problems from every stage in prod...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In-process quality control (IPQC) tests was important to remove problems from every stage in production and maintain the quality of the In-process product with standards as specified in the pharmacopoeias. The quality of FP depends on in-process control (IPC) tests because it helps to incorporate excellence within the products. The qualitative and quantitative parameters of pharmaceuticals or biopharmaceuticals products was checked by In-process quality control (IPQC). The aim of this investigation was to provide concise information on the IPQC and FPQC (finished products quality control) tests for pharmaceutical solid dosage as per different pharmacopoeias.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ac6832a022a561ab91785a7827d7b2e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":59396385,"asset_id":39262389,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/59396385/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="39262389"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="39262389"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 39262389; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="11127881" id="papers"><div class="js-work-strip profile--work_container" data-work-id="105891590"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891590/Organotin_Antifouling_Compounds_and_Sex_Steroid_Nuclear_Receptor_Perturbation_Some_Structural_Insights"><img alt="Research paper thumbnail of Organotin Antifouling Compounds and Sex-Steroid Nuclear Receptor Perturbation: Some Structural Insights" class="work-thumbnail" src="https://attachments.academia-assets.com/105235173/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891590/Organotin_Antifouling_Compounds_and_Sex_Steroid_Nuclear_Receptor_Perturbation_Some_Structural_Insights">Organotin Antifouling Compounds and Sex-Steroid Nuclear Receptor Perturbation: Some Structural Insights</a></div><div class="wp-workCard_item"><span>Toxics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Organotin compounds (OTCs) are a commercially important group of organometallic compounds of tin ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Organotin compounds (OTCs) are a commercially important group of organometallic compounds of tin used globally as polyvinyl chloride stabilizers and marine antifouling biocides. Worldwide use of OTCs has resulted in their ubiquitous presence in ecosystems across all the continents. OTCs have metabolic and endocrine disrupting effects in marine and terrestrial organisms. Thus, harmful OTCs (tributyltin) have been banned by the International Convention on the Control of Harmful Antifouling Systems since 2008. However, continued manufacturing by non-member countries poses a substantial risk for animal and human health. In this study, structural binding of common commercial OTCs, tributyltin (TBT), dibutyltin (DBT), monobutyltin (MBT), triphenyltin (TPT), diphenyltin (DPT), monophenyltin (MPT), and azocyclotin (ACT) against sex-steroid nuclear receptors, androgen receptor (AR), and estrogen receptors (ERα, ERβ) was performed using molecular docking and MD simulation. TBT, DBT, DPT, and ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cc3b7b67026ef7a22c48f2d581b1ea36" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235173,"asset_id":105891590,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235173/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891590"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891590"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891590; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891589"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891589/Potential_Disruption_of_Systemic_Hormone_Transport_by_Tobacco_Alkaloids_Using_Computational_Approaches"><img alt="Research paper thumbnail of Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches" class="work-thumbnail" src="https://attachments.academia-assets.com/105235174/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891589/Potential_Disruption_of_Systemic_Hormone_Transport_by_Tobacco_Alkaloids_Using_Computational_Approaches">Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches</a></div><div class="wp-workCard_item"><span>Toxics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tobacco/nicotine is one of the most toxic and addictive substances and continues to pose a signif...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tobacco/nicotine is one of the most toxic and addictive substances and continues to pose a significant threat to global public health. The harmful effects of smoking/nicotine affect every system in the human body. Nicotine has been associated with effects on endocrine homeostasis in humans such as the imbalance of gonadal steroid hormones, adrenal corticosteroid hormones, and thyroid hormones. The present study was conducted to characterize the structural binding interactions of nicotine and its three important metabolites, cotinine, trans-3′-hydroxycotinine, and 5′-hydroxycotinine, against circulatory hormone carrier proteins, i.e., sex-hormone-binding globulin (SHBG), corticosteroid-binding globulin (CBG), and thyroxine-binding globulin (TBG). Nicotine and its metabolites formed nonbonded contacts and/or hydrogen bonds with amino acid residues of the carrier proteins. For SHBG, Phe-67 and Met-139 were the most important amino acid residues for nicotine ligand binding showing the m...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="820ca0c061eac678c15f07bab8a6ac3c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235174,"asset_id":105891589,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235174/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891589"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891589"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891589; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891588"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891588/Insights_into_the_Endocrine_Disrupting_Activity_of_Emerging_Non_Phthalate_Alternate_Plasticizers_against_Thyroid_Hormone_Receptor_A_Structural_Perspective"><img alt="Research paper thumbnail of Insights into the Endocrine Disrupting Activity of Emerging Non-Phthalate Alternate Plasticizers against Thyroid Hormone Receptor: A Structural Perspective" class="work-thumbnail" src="https://attachments.academia-assets.com/105235171/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891588/Insights_into_the_Endocrine_Disrupting_Activity_of_Emerging_Non_Phthalate_Alternate_Plasticizers_against_Thyroid_Hormone_Receptor_A_Structural_Perspective">Insights into the Endocrine Disrupting Activity of Emerging Non-Phthalate Alternate Plasticizers against Thyroid Hormone Receptor: A Structural Perspective</a></div><div class="wp-workCard_item"><span>Toxics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Many endocrine-disrupting chemicals (EDCs) have a ubiquitous presence in our environment due to a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Many endocrine-disrupting chemicals (EDCs) have a ubiquitous presence in our environment due to anthropogenic activity. These EDCs can disrupt hormone signaling in the human and animal body systems including the very important hypothalamic-pituitary-thyroid (HPT) axis causing adverse health effects. Thyroxine (T4) and triiodothyronine (T3) are hormones of the HPT axis which are essential for regulation of metabolism, heart rate, body temperature, growth, development, etc. In this study, potential endocrine-disrupting activity of the most common phthalate plasticizer, DEHP, and emerging non-phthalate alternate plasticizers, DINCH, ATBC, and DEHA against thyroid hormone receptor (TRα) were characterized. The structural binding characterization of indicated ligands was performed against the TRα ligand binding site employing Schrodinger’s induced fit docking (IFD) approach. The molecular simulations of interactions of the ligands against the residues lining a TRα binding pocket, includi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef5d3a82a960d3e8286fd26b215f91e2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235171,"asset_id":105891588,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235171/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891588"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891588"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891588; 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(DOCX 17Â kb)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891587"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891587"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891587; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891587]").text(description); $(".js-view-count[data-work-id=105891587]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891587; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891587']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105891587]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105891587,"title":"Additional file 1: Table S1. of Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update","internal_url":"https://www.academia.edu/105891587/Additional_file_1_Table_S1_of_Spontaneous_preterm_birth_and_single_nucleotide_gene_polymorphisms_a_recent_update","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891586"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891586/Endocrine_Disruption_Structural_Interactions_of_Androgen_Receptor_against_Di_2_ethylhexyl_Phthalate_and_Its_Metabolites"><img alt="Research paper thumbnail of Endocrine Disruption: Structural Interactions of Androgen Receptor against Di(2-ethylhexyl) Phthalate and Its Metabolites" class="work-thumbnail" src="https://attachments.academia-assets.com/105235169/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891586/Endocrine_Disruption_Structural_Interactions_of_Androgen_Receptor_against_Di_2_ethylhexyl_Phthalate_and_Its_Metabolites">Endocrine Disruption: Structural Interactions of Androgen Receptor against Di(2-ethylhexyl) Phthalate and Its Metabolites</a></div><div class="wp-workCard_item"><span>Toxics</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Diethylhexyl phthalate (DEHP) is a commonly used plasticizer in the manufacture of polyvinyl chlo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Diethylhexyl phthalate (DEHP) is a commonly used plasticizer in the manufacture of polyvinyl chloride plastics for household and commercial use. DEHP is a ubiquitous ecocontaminant and causes developmental and reproductive problems in children and adults. After exposure, DEHP is metabolized by endogenous hydrolysis and oxidation into the primary metabolite, mono-(2-ethylhexyl) phthalate (MEHP), and the secondary metabolites, mono-(2-ethyl-5-hydroxhexyl)phthalate (5-OH-MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (5-oxo-MEHP), mono-(2-ethyl-5-carboxypentyl) phthalate (5-cx-MEPP), and mono-[(2-carboxymethyl)hexyl] phthalate (2-cx-MMHP). Very few studies have been reported on the adverse effects of DEHP metabolites, and the available information indicates that the metabolites might also be equally or more active as compared to the parent compound. In the present study, induced fit docking was used for structural binding characterization of the above five DEHP metabolites with androgen re...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd67bd9ba6917e10ef3ead1de405dd30" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235169,"asset_id":105891586,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235169/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891586"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891586"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891586; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891585"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891585/Plant_Mediated_Green_Synthesis_of_Zinc_Oxide_Nanoparticles_Using_Swertia_chirayita_Leaf_Extract_Characterization_and_Its_Antibacterial_Efficacy_Against_Some_Common_Pathogenic_Bacteria"><img alt="Research paper thumbnail of Plant-Mediated Green Synthesis of Zinc Oxide Nanoparticles Using Swertia chirayita Leaf Extract, Characterization and Its Antibacterial Efficacy Against Some Common Pathogenic Bacteria" class="work-thumbnail" src="https://attachments.academia-assets.com/105235190/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891585/Plant_Mediated_Green_Synthesis_of_Zinc_Oxide_Nanoparticles_Using_Swertia_chirayita_Leaf_Extract_Characterization_and_Its_Antibacterial_Efficacy_Against_Some_Common_Pathogenic_Bacteria">Plant-Mediated Green Synthesis of Zinc Oxide Nanoparticles Using Swertia chirayita Leaf Extract, Characterization and Its Antibacterial Efficacy Against Some Common Pathogenic Bacteria</a></div><div class="wp-workCard_item"><span>BioNanoScience</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The use of plant materials for the green synthesis of zinc oxide nanoparticles has enormous appli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The use of plant materials for the green synthesis of zinc oxide nanoparticles has enormous applications in pharmaceuticals, biotechnological, and biological fields. In this paper, we report Swertia chirayita leaf extract-mediated green synthesis of zinc oxide nanoparticles (ZnONPs). Furthermore, the as-prepared ZnONPs were characterized by employing Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), UV-visible spectroscopy (UV-VIS), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), and energy-dispersive x-ray spectroscopy (EDS). The antibacterial efficacy of green synthesized ZnONPs was investigated against Gram-positive (Staphylococcus aureus) as well as Gramnegative (Escherichia coli and Salmonella enterica) bacterial strains. The efficacy of Swertia chirayita-extracted ZnONPs were found to be effective against Gram-positive as well as Gram-negative bacterial strains, suggesting its plausible use in cases of resistant bacterial infections.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3a623c13cfee121d40e303b214ff82d7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235190,"asset_id":105891585,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235190/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891585"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891585"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891585; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891584"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/105891584/Structural_studies_on_inhibitory_mechanisms_of_antibiotic_corticosteroid_and_catecholamine_molecules_on_lactoperoxidase"><img alt="Research paper thumbnail of Structural studies on inhibitory mechanisms of antibiotic, corticosteroid and catecholamine molecules on lactoperoxidase" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/105891584/Structural_studies_on_inhibitory_mechanisms_of_antibiotic_corticosteroid_and_catecholamine_molecules_on_lactoperoxidase">Structural studies on inhibitory mechanisms of antibiotic, corticosteroid and catecholamine molecules on lactoperoxidase</a></div><div class="wp-workCard_item"><span>Life sciences</span><span>, Jan 15, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lactoperoxidase (LPO) is an essential protein with broad spectrum antimicrobial activity present ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lactoperoxidase (LPO) is an essential protein with broad spectrum antimicrobial activity present in mammalian milk. It imparts immunity to infants against wide range of pathogenic infections. Several in vitro studies have shown inhibition of LPO activity by pharmaceutical compounds including commonly used antibiotics such as ampicillin and gentamicin, and molecules like prednisolone, norepinephrine, etc. Prescription of such drugs to lactating mothers might have adverse health effects on infants. The aim of our study was the elucidation of the structural aspects of the inhibitory mechanism of ampicillin, gentamicin, amoxicillin, prednisolone and norepinephrine on LPO. Three dimensional structure of camel LPO (cLPO) was developed using homology modeling and used for in silico experimental studies. The Schrödinger induced fit docking along with binding affinity estimation experiments were performed. The cLPO and Ligands were prepared using Protein Preparation Wizard and Ligprep module...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891584]").text(description); $(".js-view-count[data-work-id=105891584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105891584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105891584,"title":"Structural studies on inhibitory mechanisms of antibiotic, corticosteroid and catecholamine molecules on lactoperoxidase","internal_url":"https://www.academia.edu/105891584/Structural_studies_on_inhibitory_mechanisms_of_antibiotic_corticosteroid_and_catecholamine_molecules_on_lactoperoxidase","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891583"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/105891583/Molecular_Interactions_of_Bexarotene_A_Retinoid_Drug_And_Alzheimers_A%CE%B2_Peptide_A_Docking_Study"><img alt="Research paper thumbnail of Molecular Interactions of Bexarotene - A Retinoid Drug And Alzheimer's Aβ Peptide: A Docking Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/105891583/Molecular_Interactions_of_Bexarotene_A_Retinoid_Drug_And_Alzheimers_A%CE%B2_Peptide_A_Docking_Study">Molecular Interactions of Bexarotene - A Retinoid Drug And Alzheimer's Aβ Peptide: A Docking Study</a></div><div class="wp-workCard_item"><span>Current Alzheimer research</span><span>, Jan 14, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alzheimer&#039;s disease (AD) pathogenesis is primarily hallmarked by the production and accumula...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alzheimer&#039;s disease (AD) pathogenesis is primarily hallmarked by the production and accumulation of amyloid beta (Aβ) peptide. Along with the understanding of the neurodegenerative disease progression and its pathophysiological mechanisms, development of anti-Aβ targeted effective therapeutics is essential for AD management. Numerous therapeutic approaches targeting the production, toxicity and removal of Aβ are being attempted worldwide. Prime need is to design inhibitors which can slow down the Aβ aggregation process in a physiological environment. Bexarotene (targretin) is the first of the U.S. Food and Drug Administration approved oral retinoid X receptors (RXR)-selective retinoids, or rexinoids. It is effectively used for the treatment of advanced, refractory cutaneous T cell lymphoma, and also reportedly reduces Aβ levels in AD mouse models. Administration of bexarotene facilitates intracellular Aβ clearance via RXR regulated apolipoprotein E (ApoE) production. To the bes...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891583"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891583"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891583; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891583]").text(description); $(".js-view-count[data-work-id=105891583]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891583; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891583']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="105891582"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891582/Development_of_Polymeric_Nanopaclitaxel_and_Comparison_with_Free_Paclitaxel_for_Effects_on_Cell_Proliferation_of_MCF_7_and_B16F0_Carcinoma_Cells"><img alt="Research paper thumbnail of Development of Polymeric Nanopaclitaxel and Comparison with Free Paclitaxel for Effects on Cell Proliferation of MCF-7 and B16F0 Carcinoma Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/105235166/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891582/Development_of_Polymeric_Nanopaclitaxel_and_Comparison_with_Free_Paclitaxel_for_Effects_on_Cell_Proliferation_of_MCF_7_and_B16F0_Carcinoma_Cells">Development of Polymeric Nanopaclitaxel and Comparison with Free Paclitaxel for Effects on Cell Proliferation of MCF-7 and B16F0 Carcinoma Cells</a></div><div class="wp-workCard_item"><span>Asian Pacific Journal of Cancer Prevention</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing adverse effects in normal body sites. In this study, we developed a polymeric nano drug carrier for safe delivery of the paclitaxel to the cancer that releases the drug in a sustained manner and reduces side effects. N-isopropylacrylamide/ vinyl pyrrolidone (NIPAAm/VP) nanoparticles were synthesized by radical polymerization. Physicochemical characterization of the polymeric nanoparticles was conducted using dynamic light scattering, transmission electron microscopy, scanning electron microscopy and nuclear magnetic resonance, which confirmedpolymerization of formulated nanoparticles. Drug release was assessed using a spectrophotometer and cell viability assays were carried out on the MCF-7 breast cancer and B16F0 skin cancer cell lines. NIPAAm/ VP nanoparticles demonstrated a size distribution in the 65-108 nm range and surface charge measured-15.4 mV. SEM showed the nanoparticles to be spherical in shape with a slow drug release of ~70% in PBS at 38°C over 96 h. Drug loaded nanoparticles were associated with increased viability of MCF-7 and B16F0 cells in comparison to free paclitaxel. Nano loaded paclitaxel shows high therapeutic efficiency by sustained release action for the longer period of time, i increasing its efficacy and biocompatibility for human cancer therapy. Therefore, paclitaxel loaded (NIPAAm/VP) nanoparticles may provide opportunities to expand delivery of the drug for clinical selection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d837050667f52d5b7d3f2f082736a78" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235166,"asset_id":105891582,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235166/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891582"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891582"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891582; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891581/Peroxisome_Proliferator_activated_Receptors_as_Potential_Targets_for_Carcinogenic_Activity_of_Polychlorinated_Biphenyls_A_Computational_Perspective"><img alt="Research paper thumbnail of Peroxisome Proliferator-activated Receptors as Potential Targets for Carcinogenic Activity of Polychlorinated Biphenyls: A Computational Perspective" class="work-thumbnail" src="https://attachments.academia-assets.com/105235189/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891581/Peroxisome_Proliferator_activated_Receptors_as_Potential_Targets_for_Carcinogenic_Activity_of_Polychlorinated_Biphenyls_A_Computational_Perspective">Peroxisome Proliferator-activated Receptors as Potential Targets for Carcinogenic Activity of Polychlorinated Biphenyls: A Computational Perspective</a></div><div class="wp-workCard_item"><span>Anticancer Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic c...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic chemicals that have been associated with increased risk of hepatic cancer, melanoma, non-Hodgkin lymphoma and cancer of many other body organs. Structural binding analyses of PCB 77 and PCB 118 with peroxisome proliferator-activated receptors (PPARα, PPARβ/δ and PPARγ) was performed to predict the association of PCBs with potential disruption of PPAR signaling pathways. Materials and Methods: The crystal structures of human PPARα, PPARβ/δ and PPARγ were obtained from the Protein Data Bank. Structures of PCB 77 and PCB 118 were obtained from PubChem database. Docking was performed using glide (Schrodinger) induced fit docking (IFD) module. Results: The PCB 77 and PCB 118 interacted with PPARα, PPARβ/δ and PPARγ showing an overlapping of 40-58% interacting amino acid residues with synthetic co-complex agonists of the three PPARs. The binding affinity was higher for PCB 118 than for PCB 77 during docking interactions with each of the three PPARs. Conclusion: The consistent commonality of interacting residues for PCB 77 and PCB 118 with cocomplex synthetic agonists of the PPARs together with good binding affinity suggested that the PPAR signaling pathway is a potential target for toxicologic activity of PCBs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5b850fdb8bd771eb11ede0791fc2f98b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235189,"asset_id":105891581,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235189/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891581; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891581]").text(description); $(".js-view-count[data-work-id=105891581]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891581; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891581']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891579"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891579/Human_sex_hormone_binding_globulin_as_a_potential_target_of_alternate_plasticizers_an_in_silico_study"><img alt="Research paper thumbnail of Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study" class="work-thumbnail" src="https://attachments.academia-assets.com/105235160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891579/Human_sex_hormone_binding_globulin_as_a_potential_target_of_alternate_plasticizers_an_in_silico_study">Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study</a></div><div class="wp-workCard_item"><span>BMC Structural Biology</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Currently, alternate plasticizers are used to replace phthalate plasticizers in child...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Currently, alternate plasticizers are used to replace phthalate plasticizers in children's toys, medical equipments and food packaging, due to the adverse effects of phthalate compounds on human health and laws prohibiting their use. Current information regarding the safety and potential adverse effects of alternate plasticizers is limited and recent studies have found alternate plasticizers to display similar characteristics to those observed in phthalate plasticizers. This study was undertaken to evaluate and predict the potential endocrine disrupting activity of the three most commonly used alternate plasticizers: di(2-ethylhexyl)terephthalate (DEHT), tris(2-ethylhexyl) trimellitate (TOTM), and diisononyl hexahydrophthalate (DINCH) against human sex hormone-binding globulin (SHBG) using in silico approaches. Materials and methods: The crystal structure of human SHBG (Id: 1D2S) was retrieved from Protein Data Bank. PubChem database was searched for the structures of alternate plasticizers, DEHT, TOTM, and DINCH. Docking was performed using Glide (Schrodinger) Induced Fit Docking module. Results: Induced Fit Docking of three alternate plasticizer compounds indicated that each of the three compounds fitted well into the steroid binding pocket of SHBG. Docking displays showed interactions of alternate plasticizers with 25-30 amino-acid residues of SHBG; 18-20 amino residues overlapped between the natural ligand, DHT, and the three compounds (commonality of 82-91 %). The hydrogen-bonding interaction of the amino-acid residue, Asn-82, of SHBG was also present in displays of DHT and all the three alternate phthalates. The binding affinity of all the three alternate phthalates was higher than DHT; maximum in DINCH followed by TOTM and DEHT. Conclusion: Our results suggested that the three alternate plasticizers have potential to engage the important interacting residues of SHBG and thus interfere in its steroid homeostatic function.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ced612b65cf17b4f9c04b2ebe2effb43" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235160,"asset_id":105891579,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235160/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891579"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891579"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891579; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891578"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891578/Abstracts_from_the_3rd_International_Genomic_Medicine_Conference_3rd_IGMC_2015_"><img alt="Research paper thumbnail of Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)" class="work-thumbnail" src="https://attachments.academia-assets.com/105235158/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891578/Abstracts_from_the_3rd_International_Genomic_Medicine_Conference_3rd_IGMC_2015_">Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)</a></div><div class="wp-workCard_item"><span>BMC Genomics</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The ends of linear chromosomes are called telomeres that resemble broken DNA. However, the telome...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The ends of linear chromosomes are called telomeres that resemble broken DNA. However, the telomeres are protected from the DNA damage responses due to the formation of a looping structure (Tloop) and by "capping" the telomeres with a series of shelterin proteins. It is generally thought the main, if not only, function of telomeres is protection from DNA damage responses. When telomeres get very short due to normal replicative aging, cells stop dividing due to loss of the telomere end protective functions. We have previously reported that telomeres may also have additional functions in human cells. Telomeres are characterized by a distinct chromatin structure with spreading of heterochromatin into the subtelomeric regions, but little is known about the chromatin conformation of human telomeres. We have previously shown, using a luciferase reporter introduced into telomeres, that there is a 10-fold decreased expression of the reporter compared to the reporter introduced into internal genomic loci. This phenomenon is known as Telomere Position Effects (TPE). We have also found that a human gene, interferon stimulating gene 15 (ISG15), (~1 M base pairs from the 1p36.33 telomere) is silenced in young cells with long telomerase, upregulated in cells with short telomeres and silenced again in old cells with experimentally hTERT (telomerase) elongated telomeres. However, we observed genes between ISG15 and the telomere are not regulated by classic telomere position effects (TPE). To distinguish this type of telomere length dependent regulation of gene expression from classic TPE, we have termed this type of regulation Telomere Position Effects Over Long Distances (TPE-OLD). We discovered using 3D co-FISH and a modification of Hi-C (chromosome capture followed by high-throughput sequencing), that there are a significant number of genes within the first 10 M bases distal to the telomere on many chromosomes regulated by telomere length with genes closer to the telomere not being regulated by TPE. O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="502bcdfd57484df284122e8cdb166af5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235158,"asset_id":105891578,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235158/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891578"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891578"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891578; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891577"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/105891577/Cold_abcess_neck_with_horner_s_syndrome_a_rare_entity"><img alt="Research paper thumbnail of Cold abcess neck with horner’s syndrome—a rare entity" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/105891577/Cold_abcess_neck_with_horner_s_syndrome_a_rare_entity">Cold abcess neck with horner’s syndrome—a rare entity</a></div><div class="wp-workCard_item"><span>Indian Journal of Thoracic and Cardiovascular Surgery</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891577"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891577"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891577; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105891577]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105891577,"title":"Cold abcess neck with horner’s syndrome—a rare entity","internal_url":"https://www.academia.edu/105891577/Cold_abcess_neck_with_horner_s_syndrome_a_rare_entity","owner_id":114829104,"coauthors_can_edit":true,"owner":{"id":114829104,"first_name":"Mohd Riyaz","middle_initials":null,"last_name":"Beg","page_name":"MohdRiyazBeg","domain_name":"ictmumbai","created_at":"2019-05-26T01:40:59.058-07:00","display_name":"Mohd Riyaz Beg","url":"https://ictmumbai.academia.edu/MohdRiyazBeg"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891576"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891576/Meet_In_The_Middle_Attack_A_Cryptanalysis_Approach"><img alt="Research paper thumbnail of Meet In The Middle Attack: A Cryptanalysis Approach" class="work-thumbnail" src="https://attachments.academia-assets.com/105235187/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891576/Meet_In_The_Middle_Attack_A_Cryptanalysis_Approach">Meet In The Middle Attack: A Cryptanalysis Approach</a></div><div class="wp-workCard_item"><span>International Journal of Computer Applications</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sometimes the information, which is transferred during the communication, is very much confidenti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sometimes the information, which is transferred during the communication, is very much confidential which is needed to be secure. For securing the information various encryption algorithms like DES, BLOWFISH, RC4 etc., are used. Our aim in this paper are to find the two keys using cryptanalysis method, that is used for encrypting the information transferred during communication by using the Meet in the Middle Attack on triple S-DES algorithm, instead of using Brute force attack.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4c4b02674480ae3a050ae681c19abebe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235187,"asset_id":105891576,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235187/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891576"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891576"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891576; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891575"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891575/Energy_efficient_sensor_network_security_using_Stream_cipher_mode_of_operation"><img alt="Research paper thumbnail of Energy efficient sensor network security using Stream cipher mode of operation" class="work-thumbnail" src="https://attachments.academia-assets.com/105235186/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891575/Energy_efficient_sensor_network_security_using_Stream_cipher_mode_of_operation">Energy efficient sensor network security using Stream cipher mode of operation</a></div><div class="wp-workCard_item"><span>2010 International Conference on Computer and Communication Technology (ICCCT)</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sometimes the information, which is transferred during the communication in between sensor node, ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sometimes the information, which is transferred during the communication in between sensor node, is very much confidential which is needed to be secure. Since sensor nodes are resource constrained and run on battery, energy consumption should be low to make it operate for many days. For securing the information various symmetric key encryption algorithms like DES, BLOWFISH, RC4 etc., are used. Our aim in this paper is to apply security in sensor network in such a way that it provide confidentiality with authentication using Stream cipher modes of operation, so that the energy consumption will minimizes at the sensor node and the life time of sensor node will increase.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c725cb76e90fafae31cc1ce894edd2fa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235186,"asset_id":105891575,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235186/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891575"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891575"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891575; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891574"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891574/Computational_Insights_into_the_Inhibitory_Mechanism_of_Human_AKT1_by_an_Orally_Active_Inhibitor_MK_2206"><img alt="Research paper thumbnail of Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206" class="work-thumbnail" src="https://attachments.academia-assets.com/105235192/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891574/Computational_Insights_into_the_Inhibitory_Mechanism_of_Human_AKT1_by_an_Orally_Active_Inhibitor_MK_2206">Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206</a></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The AKT signaling pathway has been identified as an important target for cancer therapy. Among sm...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The AKT signaling pathway has been identified as an important target for cancer therapy. Among small-molecule inhibitors of AKT that have shown tremendous potential in inhibiting cancer, MK-2206 is a highly potent, selective and orally active allosteric inhibitor. Promising preclinical anticancer results have led to entry of MK-2206 into Phase I/II clinical trials. Despite such importance, the exact binding mechanism and the molecular interactions of MK-2206 with human AKT are not available. The current study investigated the exact binding mode and the molecular interactions of MK-2206 with human AKT isoforms using molecular docking and (un)binding simulation analyses. The study also involved the docking analyses of the structural analogs of MK-2206 to AKT1 and proposed one as better inhibitor. The Dock was used for docking simulations of MK-2206 into the allosteric site of AKT isoforms. The Ligplot+ was used for analyses of polar and hydrophobic interactions between AKT isoforms and the ligands. The MoMa-LigPath web server was used to simulate the ligand (un)binding from the binding site to the surface of the protein. In the docking and (un)binding simulation analyses of MK-2206 with human AKT1, the Trp-80 was the key residue and showed highest decrease in the solvent accessibility, highest number of hydrophobic interactions, and the most consistent involvement in all (un)binding simulation phases. The number of molecular interactions identified and calculated binding energies and dissociation constants from the co-complex structures of these isoforms, clearly explained the varying affinity of MK-2206 towards these isoforms. The (un)binding simulation analyses identified various additional residues which despite being away from the binding site, play important role in initial binding of the ligand. Thus, the docking and (un)binding simulation analyses of MK-2206 with AKT isoforms and its structure analogs will provide a suitable model for studying drug-protein interaction and will help in designing better drugs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e3548c64abce4026abfc97a1f4845ddf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235192,"asset_id":105891574,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235192/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891574"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891574"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891574; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891573/Comparative_Study_between_Stream_Cipher_and_Block_Cipher_using_RC4_and_Hill_Cipher"><img alt="Research paper thumbnail of Comparative Study between Stream Cipher and Block Cipher using RC4 and Hill Cipher" class="work-thumbnail" src="https://attachments.academia-assets.com/105235184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891573/Comparative_Study_between_Stream_Cipher_and_Block_Cipher_using_RC4_and_Hill_Cipher">Comparative Study between Stream Cipher and Block Cipher using RC4 and Hill Cipher</a></div><div class="wp-workCard_item"><span>International Journal of Computer Applications</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sometimes the information, which is transferred during the communication, is very much confidenti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sometimes the information, which is transferred during the communication, is very much confidential which is needed to be secure. For securing the information various encryption algorithms like DES, BLOWFISH, RC4 etc., are used. Our aim in this paper is to find the two keys using cryptanalysis method, that is used for encrypting the information transferred during communication by using the Meet in the Middle Attack on triple S-DES algorithm, instead of using Brute force attack. And also we have analysed how the meet in middle attack in S-DES is better than the brute force attack to break the keys in terms of time taken, that is the key search Comparative Study between Stream Cipher and Block Cipher using RC4 and Hill Cipher</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4af8eb9e6bc3bf66bb554869f9b4fda2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235184,"asset_id":105891573,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235184/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891573"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891573"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891573; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891571"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891571/Role_of_LH_in_luteolysis_and_growth_of_the_ovulatory_follicle_and_estradiol_regulation_of_LH_secretion_in_heifers"><img alt="Research paper thumbnail of Role of LH in luteolysis and growth of the ovulatory follicle and estradiol regulation of LH secretion in heifers" class="work-thumbnail" src="https://attachments.academia-assets.com/105235188/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891571/Role_of_LH_in_luteolysis_and_growth_of_the_ovulatory_follicle_and_estradiol_regulation_of_LH_secretion_in_heifers">Role of LH in luteolysis and growth of the ovulatory follicle and estradiol regulation of LH secretion in heifers</a></div><div class="wp-workCard_item"><span>Theriogenology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The role of LH in luteolysis and development of the ovulatory follicle and the involvement of GnR...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The role of LH in luteolysis and development of the ovulatory follicle and the involvement of GnRH receptors in estradiol (E2) stimulation of LH secretion were studied in heifers. A pulse of PGF 2␣ , as indicated by a metabolite, was induced by E2 treatment on Day 15 (Day 0 ϭ ovulation) and LH concentration was reduced with a GnRH-receptor antagonist (acyline) on Days 15, 16, and 17. Blood samples were collected every 6 h on Days 14-17 and hourly for 10 h beginning at the Day-15 treatments. Four groups were used (n ϭ 6): control, acyline, E2, and E2/acyline. The number of LH pulses/heifer during the 10 h posttreatment was greater (P Ͻ 0.0002) in the E2 group (2.3 Ϯ 0.4, mean Ϯ SEM) than in the acyline group (0.2 Ϯ 0.2) and was intermediate in the E2/acyline group (1.4 Ϯ 0.2). Concentrations of progesterone in samples collected every 6 h on Day 15 showed a group-by-hour interaction (P Ͻ 0.02); concentrations decreased in the acyline group but not in the control group. The 12 heifers in the combined acyline and E2/acyline groups had three follicular waves compared to two waves in 10 of 12 heifers in the combined control and E2 groups. Results (1) supported the hypothesis that LH delays the progesterone decrease associated with luteolysis, (2) supported the hypothesis that LH has a positive effect on the continued development and growth of the selected ovulatory follicle, and (3) indicated that E2 stimulates LH production through an intracellular pathway that involves GnRH receptors on the gonadotropes and a pathway that does not involve the receptors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2087152921b4e7b259b46fed69ae2bdc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235188,"asset_id":105891571,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235188/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891571"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891571"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891571; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891569"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/105891569/Anticancer_Compound_Plumbagin_and_Its_Molecular_Targets_A_Structural_Insight_into_the_Inhibitory_Mechanisms_Using_Computational_Approaches"><img alt="Research paper thumbnail of Anticancer Compound Plumbagin and Its Molecular Targets: A Structural Insight into the Inhibitory Mechanisms Using Computational Approaches" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/105891569/Anticancer_Compound_Plumbagin_and_Its_Molecular_Targets_A_Structural_Insight_into_the_Inhibitory_Mechanisms_Using_Computational_Approaches">Anticancer Compound Plumbagin and Its Molecular Targets: A Structural Insight into the Inhibitory Mechanisms Using Computational Approaches</a></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891569"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891569"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891569; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105891569]").text(description); $(".js-view-count[data-work-id=105891569]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105891569; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105891569']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105891567"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105891567/Plasma_Clearance_and_Half_Life_of_Prostaglandin_F2alpha_A_Comparison_Between_Mares_and_Heifers1"><img alt="Research paper thumbnail of Plasma Clearance and Half-Life of Prostaglandin F2alpha: A Comparison Between Mares and Heifers1" class="work-thumbnail" src="https://attachments.academia-assets.com/105235183/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105891567/Plasma_Clearance_and_Half_Life_of_Prostaglandin_F2alpha_A_Comparison_Between_Mares_and_Heifers1">Plasma Clearance and Half-Life of Prostaglandin F2alpha: A Comparison Between Mares and Heifers1</a></div><div class="wp-workCard_item"><span>Biology of Reproduction</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Horses are about five times more sensitive to the luteolytic effect of prostaglandin F2alpha (PGF...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Horses are about five times more sensitive to the luteolytic effect of prostaglandin F2alpha (PGF) than cattle, as indicated by a recommended clinical dose of 5 mg in horses and 25 mg in cattle. Novel evaluations of the PGF plasma disappearance curves were made in mares and in heifers, and the two species were compared. Mares and heifers (n ¼ 5) of similar body weight were injected (Min 0) intravenously with PGF (5 mg per animal). Blood was sampled every 10 sec until Min 3, every 30 sec until Min 5, every 10 min until Min 60, and every 30 min until Min 240. The mean PGF concentration was greater (P , 0.05) in mares than in heifers at Min 1 through Min 60 and at Mins 180 and 240. The mean time to maximum PGF concentration was not different between mares (42.0 6 8.6 sec) and heifers (35.0 6 2.9 sec). The apparent plasma clearance, distribution halflife, elimination half-life, and maximum plasma PGF concentration were 3.3 6 0.5 L h À1 kg À1 , 94.2 6 15.9 sec, 25.9 6 5.0 min, and 249.1 6 36.8 ng/ml, respectively, in mares and 15.4 6 2.3 L h À1 kg À1 , 29.2 6 3.9 sec, 9.0 6 0.9 min, and 51.4 6 22.6 ng/ml, respectively, in heifers. Plasma clearance was about five times less (P , 0.0005), maximum plasma PGF concentration was five times greater (P , 0.002), and the distribution half-life and elimination half-life were about three times longer (P , 0.005) in mares than in heifers. The fivefold greater plasma clearance of PGF in heifers than in mares corresponds to the recommended fivefold greater clinical dose of PGF in cattle and supported the hypothesis that the metabolic clearance of PGF is slower in mares than heifers.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7cdd03273995bfb536cfacf009031df4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105235183,"asset_id":105891567,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105235183/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105891567"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105891567"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105891567; 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