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class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Rosalinda Díaz</h3></div><div class="js-work-strip profile--work_container" data-work-id="28314758"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/28314758/Disruption_of_visual_and_motor_connectivity_in_spinocerebellar_ataxia_type_7"><img alt="Research paper thumbnail of Disruption of visual and motor connectivity in spinocerebellar ataxia type 7" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/28314758/Disruption_of_visual_and_motor_connectivity_in_spinocerebellar_ataxia_type_7">Disruption of visual and motor connectivity in spinocerebellar ataxia type 7</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LizbethGarcia21">Lizbeth Garcia</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a></span></div><div class="wp-workCard_item"><span>Movement Disorders</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characte...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region-specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel-based morphometry and resting-state fMRI, we studied 26 genetically confirmed SCA7 patients and aged-matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo- and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28314758"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28314758"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28314758; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28314758]").text(description); $(".js-view-count[data-work-id=28314758]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28314758; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28314758']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28314758]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28314758,"title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7","translated_title":"","metadata":{"abstract":"Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region-specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel-based morphometry and resting-state fMRI, we studied 26 genetically confirmed SCA7 patients and aged-matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo- and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Movement Disorders"},"translated_abstract":"Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region-specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel-based morphometry and resting-state fMRI, we studied 26 genetically confirmed SCA7 patients and aged-matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo- and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7.","internal_url":"https://www.academia.edu/28314758/Disruption_of_visual_and_motor_connectivity_in_spinocerebellar_ataxia_type_7","translated_internal_url":"","created_at":"2016-09-07T07:50:39.845-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":45486114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24113511,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":null,"co_author_invite_id":983726,"email":"w***o@email.unc.edu","display_order":0,"name":"Wei Gao","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113512,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":34771516,"co_author_invite_id":null,"email":"j***r@unam.mx","display_order":4194304,"name":"Juan Fernandez-ruiz","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113513,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":49779173,"co_author_invite_id":null,"email":"y***p@gmail.com","display_order":6291456,"name":"Petra Yescas","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113514,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":null,"co_author_invite_id":1842108,"email":"a***r@gmail.com","display_order":7340032,"name":"Sarael Alcauter","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113515,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":8880361,"co_author_invite_id":null,"email":"g***r@yahoo.com","display_order":7864320,"name":"victor galvez","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113516,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":null,"co_author_invite_id":5369871,"email":"f***a@hotmail.com","display_order":8126464,"name":"Fernando Barrios","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113517,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":37081080,"co_author_invite_id":null,"email":"d***4@hotmail.com","affiliation":"Universidad Nacional Autónoma de México","display_order":8257536,"name":"Rosalinda Díaz","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"}],"downloadable_attachments":[],"slug":"Disruption_of_visual_and_motor_connectivity_in_spinocerebellar_ataxia_type_7","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region-specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel-based morphometry and resting-state fMRI, we studied 26 genetically confirmed SCA7 patients and aged-matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo- and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7.","owner":{"id":45486114,"first_name":"Lizbeth","middle_initials":null,"last_name":"Garcia","page_name":"LizbethGarcia21","domain_name":"independent","created_at":"2016-03-20T14:16:34.048-07:00","display_name":"Lizbeth Garcia","url":"https://independent.academia.edu/LizbethGarcia21"},"attachments":[],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":43367,"name":"Movement disorders","url":"https://www.academia.edu/Documents/in/Movement_disorders"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":357850,"name":"Atrophy","url":"https://www.academia.edu/Documents/in/Atrophy"},{"id":1257483,"name":"Frontal Lobe","url":"https://www.academia.edu/Documents/in/Frontal_Lobe"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355871"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17355871/Extensive_White_Matter_Alterations_and_Its_Correlations_with_Ataxia_Severity_in_SCA_2_Patients"><img alt="Research paper thumbnail of Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17355871/Extensive_White_Matter_Alterations_and_Its_Correlations_with_Ataxia_Severity_in_SCA_2_Patients">Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Previous studies of SCA2 have revealed significant degeneration of white matter tracts in cerebel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Previous studies of SCA2 have revealed significant degeneration of white matter tracts in cerebellar and cerebral regions. The motor deficit in these patients may be attributable to the degradation of projection fibers associated with the underlying neurodegenerative process. However, this relationship remains unclear. Statistical analysis of diffusion tensor imaging enables an unbiased whole-brain quantitative comparison of the diffusion proprieties of white matter tracts in vivo. Fourteen genetically confirmed SCA2 patients and aged-matched healthy controls participated in the study. Tract-based spatial statistics were performed to analyze structural white matter damage using two different measurements: fractional anisotropy (FA) and mean diffusivity (MD). Significant diffusion differences were correlated with the patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s ataxia impairment. Our analysis revealed decreased FA mainly in the inferior/middle/superior cerebellar peduncles, the bilateral posterior limb of the internal capsule and the bilateral superior corona radiata. Increases in MD were found mainly in cerebellar white matter, medial lemniscus, and middle cerebellar peduncle, among other regions. Clinical impairment measured with the SARA score correlated with FA in superior parietal white matter and bilateral anterior corona radiata. Correlations with MD were found in cerebellar white matter and the middle cerebellar peduncle. Our findings show significant correlations between diffusion measurements in key areas affected in SCA2 and measures of motor impairment, suggesting a disruption of information flow between motor and sensory-integration areas. These findings result in a more comprehensive view of the clinical impact of the white matter degeneration in SCA2.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355871"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355871"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355871; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355871]").text(description); $(".js-view-count[data-work-id=17355871]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355871; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355871']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17355871]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355871,"title":"Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients","internal_url":"https://www.academia.edu/17355871/Extensive_White_Matter_Alterations_and_Its_Correlations_with_Ataxia_Severity_in_SCA_2_Patients","owner_id":37081080,"coauthors_can_edit":true,"owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277902"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17277902/Functional_connectivity_changes_related_to_cognitive_and_motor_performance_in_spinocerebellar_ataxia_type_2"><img alt="Research paper thumbnail of Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2" class="work-thumbnail" src="https://attachments.academia-assets.com/42274414/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17277902/Functional_connectivity_changes_related_to_cognitive_and_motor_performance_in_spinocerebellar_ataxia_type_2">Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PetraYescas">Petra Yescas</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>Movement Disorders</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f4c3bf7f4af44279b828b58681865d7f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42274414,"asset_id":17277902,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42274414/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277902"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277902"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277902; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277902]").text(description); $(".js-view-count[data-work-id=17277902]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277902; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277902']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f4c3bf7f4af44279b828b58681865d7f" } } $('.js-work-strip[data-work-id=17277902]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277902,"title":"Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2","internal_url":"https://www.academia.edu/17277902/Functional_connectivity_changes_related_to_cognitive_and_motor_performance_in_spinocerebellar_ataxia_type_2","owner_id":36925655,"coauthors_can_edit":true,"owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[{"id":42274414,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42274414/thumbnails/1.jpg","file_name":"Functional_connectivity_changes_related_20160207-22903-13lb4jq.pdf","download_url":"https://www.academia.edu/attachments/42274414/download_file","bulk_download_file_name":"Functional_connectivity_changes_related.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42274414/Functional_connectivity_changes_related_20160207-22903-13lb4jq-libre.pdf?1454839007=\u0026response-content-disposition=attachment%3B+filename%3DFunctional_connectivity_changes_related.pdf\u0026Expires=1740145517\u0026Signature=OQoSVhhN-WQrRmuC4BVLitLUk1PW1gQURjKBJ-vssjag6C8iiWE~CA3P44e3MTPGCeXSy1eSShwqJgt1Tyxxycj3g7UkztC7gwgNM948ae~1iMLNEk8Q9A66UKKQvc1i01kMLPG-0~s~ua4ndA~7--wBxvsHbfbKAop-jD8UJ7uDpk1kWDSsvsTtj4Z0dGqnIdc4iMxbsTjG3jqi~7u03T4RhdwdEWEReWWU64SM71j5Zre-MgdVO4m6daUevEt-WT2r9lC3e7H1CXglOAsCpU7~td7yMcXvIOGg3n8ZUfR5U3QUtaF09~MJ1AxxOZrGwutzQ28J6dyrf-wf7~mtkA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355870"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355870/The_Effect_of_Spatial_Working_Memory_Deterioration_on_Strategic_Visuomotor_Learning_across_Aging"><img alt="Research paper thumbnail of The Effect of Spatial Working Memory Deterioration on Strategic Visuomotor Learning across Aging" class="work-thumbnail" src="https://attachments.academia-assets.com/42266015/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355870/The_Effect_of_Spatial_Working_Memory_Deterioration_on_Strategic_Visuomotor_Learning_across_Aging">The Effect of Spatial Working Memory Deterioration on Strategic Visuomotor Learning across Aging</a></div><div class="wp-workCard_item"><span>Behavioural Neurology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective. To evaluate the effect of age-related cognitive changes in a visuomotor learning task ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective. To evaluate the effect of age-related cognitive changes in a visuomotor learning task that depends on strategic control and contrast it with the effect in a task principally depending on visuomotor recalibration. Methods. Participants performed a ball throwing task while donning either a reversing dove prism or a displacement wedge prism, which mainly depend on strategic control or visuomotor recalibration, respectively. Visuomotor performance was then analysed in relation to rule acquisition and reversal, recognition memory, visual memory, spatial planning, and spatial working memory with tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Results. The results confirmed previous works showing a detrimental effect of age on visuomotor learning. The analyses of the cognitive changes observed across age showed that both strategic control and visuomotor recalibration had significant negative correlations only with the number of errors in the spatial working memory task. However, when the effect of aging was controlled, the only significant correlation remaining was between the reversal adaptation magnitude and spatial working memory. Discussion. These results suggest that spatial working memory decline across aging could contribute to age-dependent deterioration in both visuomotor learning processes. However, spatial working memory integrity seems to affect strategic learning decline even after controlling for aging.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dc50fe55a0e55175dd214c24c4c16e1f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42266015,"asset_id":17355870,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42266015/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355870"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355870"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355870; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355868"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355868/Social_and_Cultural_Elements_Associated_with_Neurocognitive_Dysfunctions_in_Spinocerebellar_Ataxia_Type_2_Patients"><img alt="Research paper thumbnail of Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients" class="work-thumbnail" src="https://attachments.academia-assets.com/41885582/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355868/Social_and_Cultural_Elements_Associated_with_Neurocognitive_Dysfunctions_in_Spinocerebellar_Ataxia_Type_2_Patients">Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://uam-xochimilco.academia.edu/LorenaPazparedes">Lorena Paz paredes</a></span></div><div class="wp-workCard_item"><span>Frontiers in Psychiatry</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico. Ethnographic records and photographic and video archives about the quotidian participant's routine were obtained from the patients, their relatives and their caregivers. The information was categorized and interpreted taking into consideration cultural issues and patients' medical files. Our analyses suggest that most of the participants do not understand the nature of the disease and this misunderstanding favors magic and non-medical explanations. Patients' testimonies suggest a decrease in pain perception as well as motor alterations that may be related to interoceptive dysfunctions. Relatives' testimonies indicate patients' lack of social and emotional interests that may be related to frontal, temporal, and cerebellar degeneration. In general, participants use their religious beliefs to deal with the disease and only a few of them trust the health system. Patients and their families are either openly rejected and ignored, tolerated or even helped by their community accordingly to different regional traits. We propose that ethnography can provide social representations to understand the patients' alterations, to formulate neurobiological hypotheses, to develop neurocognitive interventions, and to improve the medical approach to the disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e334dd34ba77b08b5f14b7607547c6a6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41885582,"asset_id":17355868,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41885582/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355868"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355868"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355868; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355868]").text(description); $(".js-view-count[data-work-id=17355868]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355868; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355868']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e334dd34ba77b08b5f14b7607547c6a6" } } $('.js-work-strip[data-work-id=17355868]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355868,"title":"Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients","translated_title":"","metadata":{"grobid_abstract":"Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico. Ethnographic records and photographic and video archives about the quotidian participant's routine were obtained from the patients, their relatives and their caregivers. The information was categorized and interpreted taking into consideration cultural issues and patients' medical files. Our analyses suggest that most of the participants do not understand the nature of the disease and this misunderstanding favors magic and non-medical explanations. Patients' testimonies suggest a decrease in pain perception as well as motor alterations that may be related to interoceptive dysfunctions. Relatives' testimonies indicate patients' lack of social and emotional interests that may be related to frontal, temporal, and cerebellar degeneration. In general, participants use their religious beliefs to deal with the disease and only a few of them trust the health system. Patients and their families are either openly rejected and ignored, tolerated or even helped by their community accordingly to different regional traits. 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Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico. Ethnographic records and photographic and video archives about the quotidian participant's routine were obtained from the patients, their relatives and their caregivers. The information was categorized and interpreted taking into consideration cultural issues and patients' medical files. Our analyses suggest that most of the participants do not understand the nature of the disease and this misunderstanding favors magic and non-medical explanations. Patients' testimonies suggest a decrease in pain perception as well as motor alterations that may be related to interoceptive dysfunctions. Relatives' testimonies indicate patients' lack of social and emotional interests that may be related to frontal, temporal, and cerebellar degeneration. In general, participants use their religious beliefs to deal with the disease and only a few of them trust the health system. Patients and their families are either openly rejected and ignored, tolerated or even helped by their community accordingly to different regional traits. We propose that ethnography can provide social representations to understand the patients' alterations, to formulate neurobiological hypotheses, to develop neurocognitive interventions, and to improve the medical approach to the disease.","owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[{"id":41885582,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41885582/thumbnails/1.jpg","file_name":"Social_and_Cultural_Elements_Associated_20160202-30232-7o7o2s.pdf","download_url":"https://www.academia.edu/attachments/41885582/download_file","bulk_download_file_name":"Social_and_Cultural_Elements_Associated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41885582/Social_and_Cultural_Elements_Associated_20160202-30232-7o7o2s-libre.pdf?1454417693=\u0026response-content-disposition=attachment%3B+filename%3DSocial_and_Cultural_Elements_Associated.pdf\u0026Expires=1738743564\u0026Signature=ZsJTHyY24S~08fkZ~otDqcTj-1SMYVRc0fk3CSaO22bG8hz8OWdYjTr0w5jYD6lmwj9KH38PJAMwy4DIsqL~JNFI1OhhymcAF6ueK3jZZ9kQG998wDmnnx~XpW2jPS~1CbtC45rj06YVubWyH-R2WZWeDtmZ5mBaAj3XD-Z6S91lzGUgfAY0yQj7pwqOn0dLVXFnt5WphEFUUD-qtWL8UysqfDBDFMRo9m0M-X-lGOycvsKxz2wZUtamRmFDVX0JA4JPwap7VVXD~0ywLKprlygxXaLMAY02nNXHT-DEg9f~kuLD73p3KEtz20Dy3ZXZJJ0B-mah2LUD7530itf7iQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":6305832,"url":"https://www.researchgate.net/profile/Victor_Galvez2/publication/278018225_Social_and_Cultural_Elements_Associated_with_Neurocognitive_Dysfunctions_in_Spinocerebellar_Ataxia_Type_2_Patients/links/55786b4708aeb6d8c01f156e.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355867"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17355867/Effects_of_aging_on_strategic_based_visuomotor_learning"><img alt="Research paper thumbnail of Effects of aging on strategic-based visuomotor learning" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17355867/Effects_of_aging_on_strategic_based_visuomotor_learning">Effects of aging on strategic-based visuomotor learning</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://uv-mx.academia.edu/LuisBeltranParrazal">Luis Beltran-Parrazal</a></span></div><div class="wp-workCard_item"><span>Brain Research</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There are different kinds of visuomotor learnings. One of the most studied is error-based learnin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There are different kinds of visuomotor learnings. One of the most studied is error-based learning where the information about the sign and magnitude of the error is used to update the motor commands. However, there are other instances where subjects show visuomotor learning even if the use of error sign and magnitude information is precluded. In those instances subjects could be using strategic instead of procedural adaptation mechanisms. Here, we present the results of the effect of aging on visuomotor strategic learning under a reversed error feedback condition, and its contrast with procedural visuomotor learning within the same participants. A number of measures were obtained from a task consisting of throwing clay balls to a target before, during and after wearing lateral displacing or reversing prisms. The displacing prism results show an age dependent decrease on the learning rate that corroborates previous findings. The reversing prism results also show significant adaptation impairment in the aged population. However, decreased reversing learning in the older group was the result of an increase in the number of subjects that could not adapt to the reversing prism, and not on a reduction of the learning capacity of all the individuals of the group. These results suggest a significant deleterious effect of aging on visuomotor strategic learning implementation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355867"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355867"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355867; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355867]").text(description); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17355867]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355867,"title":"Effects of aging on strategic-based visuomotor learning","internal_url":"https://www.academia.edu/17355867/Effects_of_aging_on_strategic_based_visuomotor_learning","owner_id":37081080,"coauthors_can_edit":true,"owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277901"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17277901/Strategy_Use_Planning_and_Rule_Acquisition_Deficits_in_Spinocerebellar_Ataxia_Type_2_Patients"><img alt="Research paper thumbnail of Strategy Use, Planning, and Rule Acquisition Deficits in Spinocerebellar Ataxia Type 2 Patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17277901/Strategy_Use_Planning_and_Rule_Acquisition_Deficits_in_Spinocerebellar_Ataxia_Type_2_Patients">Strategy Use, Planning, and Rule Acquisition Deficits in Spinocerebellar Ataxia Type 2 Patients</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>Journal of the International Neuropsychological Society</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Our goal was to improve spinocerebellar ataxia type 2 (SCA2) cognitive profile characterization b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Our goal was to improve spinocerebellar ataxia type 2 (SCA2) cognitive profile characterization by testing the hypothesis that strategy, planning and rule acquisition capacities are affected in SCA2. Forty one patients with SCA2 were evaluated with the Spatial Working Memory (SWM), the Stockings of Cambridge (SOC), and the Intra-Extra Dimensional Shift (IED) tests of the Executive module of the Cambridge Neuropsychological Testing Automated Battery (CANTAB). Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) from the CANTAB memory module were also assessed to corroborate previous findings. Motor deterioration was measured using the Scale for the Assessment and Rating of Ataxia (SARA). We found significant SCA2 related deficits in strategy, planning, and rule acquisition. Our results also corroborated significant memory deficits in these patients with SCA2. Further analysis also showed that patients with large motor deterioration had poorer associative learning and spatial planning scores. Patients with SCA2 show strategy, planning, and rule acquisition deficits as revealed with the CANTAB battery. These deficits should be noted when planning an effective therapy for these patients. (JINS, 2015, 21, 1-7).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277901"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277901"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277901; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277901]").text(description); $(".js-view-count[data-work-id=17277901]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277901; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277901']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17277901]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277901,"title":"Strategy Use, Planning, and Rule Acquisition Deficits in Spinocerebellar Ataxia Type 2 Patients","internal_url":"https://www.academia.edu/17277901/Strategy_Use_Planning_and_Rule_Acquisition_Deficits_in_Spinocerebellar_Ataxia_Type_2_Patients","owner_id":36925655,"coauthors_can_edit":true,"owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355866"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355866/Gray_and_white_matter_alterations_in_spinocerebellar_ataxia_type_7_An_in_vivo_DTI_and_VBM_study"><img alt="Research paper thumbnail of Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study" class="work-thumbnail" src="https://attachments.academia-assets.com/41884361/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355866/Gray_and_white_matter_alterations_in_spinocerebellar_ataxia_type_7_An_in_vivo_DTI_and_VBM_study">Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study</a></div><div class="wp-workCard_item"><span>NeuroImage</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Spinocerebellar ataxia SCA7 Voxel based morphometry Diffusion tensor imaging Tract-based spatial ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Spinocerebellar ataxia SCA7 Voxel based morphometry Diffusion tensor imaging Tract-based spatial statistics CAG Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder characterized by cerebellar ataxia and visual loss. It is caused by a CAG repeat expansion in the gene encoding the ataxin 7 protein. Visual loss is due to a progressive atrophy of photoreceptor cells that results in macular degeneration in more advanced stages. Initial semiautomatic measures in magnetic resonance imaging (MRI) studies on the brain stem have shown a diminished volume mainly in the cerebellum and pons, while T2 images have shown hyperintensities in transverse fibers at the pons. Neuropathological research, however, has shown more widespread brain damage including loss of myelinated fibers. In this study we decided to take advantage of recent MRI methodological advances to further explore the gray and white matter changes that occur in SCA7 patients. We studied nine genetically confirmed SCA7 patients and their matched controls using voxel based morphometry and tract-based spatial statistics. As expected, we found significant bilateral gray matter volume reductions (p b 0.05, corrected for multiple comparisons) in patients' cerebellar cortex. However, we also found significant bilateral gray matter reductions in pre and postcentral gyrus, inferior and medial frontal, parietal inferior, parahippocampal and occipital cortices. The analysis also showed a decrement in fractional anisotropy (p b 0.05, corrected) of SCA7 patients in the cerebellum's white matter, brainstem, cerebellar and cerebral peduncles, midbrain, anterior and posterior internal capsule, external/extreme capsule, corpus callosum, corona radiata, optical radiations, and the occipital, temporal and frontal lobe's white matter. These results confirm previous evidence of widespread damage beyond the cerebellum and the pons in SCA7 patients. They also confirmed previous results that had been only detectable through neuropathological analyses and, more importantly, identified new regions affected by the disease that previous methods could not detect. These new results could help explain the symptom's spectrum that affects these patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="37ff406c1fbbc0b4628373fb0594bdbd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41884361,"asset_id":17355866,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41884361/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355866"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355866"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355866; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355866]").text(description); $(".js-view-count[data-work-id=17355866]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355866; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355866']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "37ff406c1fbbc0b4628373fb0594bdbd" } } $('.js-work-strip[data-work-id=17355866]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355866,"title":"Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study","translated_title":"","metadata":{"grobid_abstract":"Spinocerebellar ataxia SCA7 Voxel based morphometry Diffusion tensor imaging Tract-based spatial statistics CAG Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder characterized by cerebellar ataxia and visual loss. It is caused by a CAG repeat expansion in the gene encoding the ataxin 7 protein. Visual loss is due to a progressive atrophy of photoreceptor cells that results in macular degeneration in more advanced stages. Initial semiautomatic measures in magnetic resonance imaging (MRI) studies on the brain stem have shown a diminished volume mainly in the cerebellum and pons, while T2 images have shown hyperintensities in transverse fibers at the pons. Neuropathological research, however, has shown more widespread brain damage including loss of myelinated fibers. In this study we decided to take advantage of recent MRI methodological advances to further explore the gray and white matter changes that occur in SCA7 patients. We studied nine genetically confirmed SCA7 patients and their matched controls using voxel based morphometry and tract-based spatial statistics. As expected, we found significant bilateral gray matter volume reductions (p b 0.05, corrected for multiple comparisons) in patients' cerebellar cortex. However, we also found significant bilateral gray matter reductions in pre and postcentral gyrus, inferior and medial frontal, parietal inferior, parahippocampal and occipital cortices. The analysis also showed a decrement in fractional anisotropy (p b 0.05, corrected) of SCA7 patients in the cerebellum's white matter, brainstem, cerebellar and cerebral peduncles, midbrain, anterior and posterior internal capsule, external/extreme capsule, corpus callosum, corona radiata, optical radiations, and the occipital, temporal and frontal lobe's white matter. These results confirm previous evidence of widespread damage beyond the cerebellum and the pons in SCA7 patients. They also confirmed previous results that had been only detectable through neuropathological analyses and, more importantly, identified new regions affected by the disease that previous methods could not detect. 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It is caused by a CAG repeat expansion in the gene encoding the ataxin 7 protein. Visual loss is due to a progressive atrophy of photoreceptor cells that results in macular degeneration in more advanced stages. Initial semiautomatic measures in magnetic resonance imaging (MRI) studies on the brain stem have shown a diminished volume mainly in the cerebellum and pons, while T2 images have shown hyperintensities in transverse fibers at the pons. Neuropathological research, however, has shown more widespread brain damage including loss of myelinated fibers. In this study we decided to take advantage of recent MRI methodological advances to further explore the gray and white matter changes that occur in SCA7 patients. We studied nine genetically confirmed SCA7 patients and their matched controls using voxel based morphometry and tract-based spatial statistics. As expected, we found significant bilateral gray matter volume reductions (p b 0.05, corrected for multiple comparisons) in patients' cerebellar cortex. However, we also found significant bilateral gray matter reductions in pre and postcentral gyrus, inferior and medial frontal, parietal inferior, parahippocampal and occipital cortices. The analysis also showed a decrement in fractional anisotropy (p b 0.05, corrected) of SCA7 patients in the cerebellum's white matter, brainstem, cerebellar and cerebral peduncles, midbrain, anterior and posterior internal capsule, external/extreme capsule, corpus callosum, corona radiata, optical radiations, and the occipital, temporal and frontal lobe's white matter. These results confirm previous evidence of widespread damage beyond the cerebellum and the pons in SCA7 patients. They also confirmed previous results that had been only detectable through neuropathological analyses and, more importantly, identified new regions affected by the disease that previous methods could not detect. These new results could help explain the symptom's spectrum that affects these patients.","owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[{"id":41884361,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41884361/thumbnails/1.jpg","file_name":"Gray_and_white_matter_alterations_in_spi20160202-30232-6e92t3.pdf","download_url":"https://www.academia.edu/attachments/41884361/download_file","bulk_download_file_name":"Gray_and_white_matter_alterations_in_spi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41884361/Gray_and_white_matter_alterations_in_spi20160202-30232-6e92t3-libre.pdf?1454417211=\u0026response-content-disposition=attachment%3B+filename%3DGray_and_white_matter_alterations_in_spi.pdf\u0026Expires=1738743564\u0026Signature=bKXdrh~azfgyvYdntijGrKxGQGRoosBF86dbGryQOR0VJEqLdEF0M1QEDhj9zm8HoUGPaf3lGbeigdcXDKkv-0edpUZu1FoCF4jNOw5sOvONVvOBuTcmvmkJfiI~nQLrhKpOvbHy9I0aTyUTLp8Y0we1SoaMxOmqQe-x0kx-LeFYe~Zcdjh1d71kI0q0KctKVKo2HA3bwVKR00BN0hjsggj-4Psu3aL6o4fX7lIQqZpp8RysnvwfjiQb7597K4~b8gI6SlrO-iNGpbiKu3yU-iPwtsNyKRxZRjncP8ab54EP5zsRgzylRZIyEbHWK~BPxeIN8751mkWaTlKFcF4kDA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":32913,"name":"Neuroimmunology","url":"https://www.academia.edu/Documents/in/Neuroimmunology"},{"id":40272,"name":"Macular Degeneration","url":"https://www.academia.edu/Documents/in/Macular_Degeneration"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":65614,"name":"Corpus Callosum","url":"https://www.academia.edu/Documents/in/Corpus_Callosum"},{"id":103260,"name":"Neuroimage","url":"https://www.academia.edu/Documents/in/Neuroimage"},{"id":103265,"name":"Voxel Based Morphometry","url":"https://www.academia.edu/Documents/in/Voxel_Based_Morphometry"},{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":146326,"name":"Cerebellar ataxia","url":"https://www.academia.edu/Documents/in/Cerebellar_ataxia"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum"},{"id":362036,"name":"White matter","url":"https://www.academia.edu/Documents/in/White_matter"},{"id":396677,"name":"Multiple comparisons","url":"https://www.academia.edu/Documents/in/Multiple_comparisons"},{"id":497323,"name":"Fractional Anisotropy","url":"https://www.academia.edu/Documents/in/Fractional_Anisotropy"},{"id":1250577,"name":"Gray Matter","url":"https://www.academia.edu/Documents/in/Gray_Matter"},{"id":1431361,"name":"Brain Damage","url":"https://www.academia.edu/Documents/in/Brain_Damage"}],"urls":[{"id":6305059,"url":"https://www.researchgate.net/profile/Juan_Fernandez-Ruiz/publication/49673151_Gray_and_white_matter_alterations_in_spinocerebellar_ataxia_type_7_an_in_vivo_DTI_and_VBM_study/links/5421d9d20cf26120b7a00b92.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355865"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355865/Decay_of_prism_aftereffects_under_passive_and_active_conditions"><img alt="Research paper thumbnail of Decay of prism aftereffects under passive and active conditions" class="work-thumbnail" src="https://attachments.academia-assets.com/39464186/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355865/Decay_of_prism_aftereffects_under_passive_and_active_conditions">Decay of prism aftereffects under passive and active conditions</a></div><div class="wp-workCard_item"><span>Cognitive Brain Research</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In prism adaptation, subjects adapt to new visuospatial coordinates imposed by wedge prisms that ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In prism adaptation, subjects adapt to new visuospatial coordinates imposed by wedge prisms that laterally displace the visual field. During this process, subjects develop and store new visuomotor coordinates in order to compensate for the displacement of visual stimuli. After the prisms are removed, subjects show an aftereffect in the opposite direction of the original perturbation. The aftereffect is a manifestation of the recently stored information. In the present article, we were interested in studying the properties of the aftereffect. Specifically, we investigated the fate of the aftereffect under active conditions with motor reafferences but without visual input, and during passive conditions without visual or motor reafferences. The results in the motor active condition show that motor reafference (proprioceptive or corollary discharge information) led to a faster, but incomplete, aftereffect decay. The results in the passive condition show a bimodal aftereffect behavior, with a fast decay within the initial minutes, followed by a sustained aftereffect up to 20 min later. These data suggests that two different memory processes may contribute to the aftereffect, one showing a fast decay mainly within 1 min, and another that shows a stable endurance for more than 20 min. D 2004 Elsevier B.V. All rights reserved.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e39311c26acecd89cacf028739dd2a94" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464186,"asset_id":17355865,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464186/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355865"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355865"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355865; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277897"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17277897/Motor_Decline_in_Clinically_Presymptomatic_Spinocerebellar_Ataxia_Type_2_Gene_Carriers"><img alt="Research paper thumbnail of Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers" class="work-thumbnail" src="https://attachments.academia-assets.com/42274408/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17277897/Motor_Decline_in_Clinically_Presymptomatic_Spinocerebellar_Ataxia_Type_2_Gene_Carriers">Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Motor deficits are a critical component of the clinical characteristics of patients w...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Motor deficits are a critical component of the clinical characteristics of patients with spinocerebellar ataxia type 2. However, there is no current information on the preclinical manifestation of those motor deficits in presymptomatic gene carriers. To further understand and characterize the onset of the clinical manifestation in this disease, we tested presymptomatic spinocerebellar ataxia type 2 gene carriers, and volunteers, in a task that evaluates their motor performance and their motor learning capabilities.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="50fb795b3bda1fe4d1c82e4214c14769" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42274408,"asset_id":17277897,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42274408/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277897"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277897"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277897; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277897]").text(description); $(".js-view-count[data-work-id=17277897]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277897; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277897']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "50fb795b3bda1fe4d1c82e4214c14769" } } $('.js-work-strip[data-work-id=17277897]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277897,"title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers","translated_title":"","metadata":{"grobid_abstract":"Background: Motor deficits are a critical component of the clinical characteristics of patients with spinocerebellar ataxia type 2. 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To further understand and characterize the onset of the clinical manifestation in this disease, we tested presymptomatic spinocerebellar ataxia type 2 gene carriers, and volunteers, in a task that evaluates their motor performance and their motor learning capabilities.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"PLoS ONE","grobid_abstract_attachment_id":42274408},"translated_abstract":null,"internal_url":"https://www.academia.edu/17277897/Motor_Decline_in_Clinically_Presymptomatic_Spinocerebellar_Ataxia_Type_2_Gene_Carriers","translated_internal_url":"","created_at":"2015-10-25T09:31:14.417-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36925655,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":7949012,"work_id":17277897,"tagging_user_id":36925655,"tagged_user_id":null,"co_author_invite_id":1774862,"email":"l***6@yahoo.com","display_order":0,"name":"Luis Almaguer-mederos","title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers"},{"id":7949057,"work_id":17277897,"tagging_user_id":36925655,"tagged_user_id":37081080,"co_author_invite_id":1774868,"email":"d***4@hotmail.com","affiliation":"Universidad Nacional Autónoma de México","display_order":4194304,"name":"Rosalinda Díaz","title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers"},{"id":7949076,"work_id":17277897,"tagging_user_id":36925655,"tagged_user_id":null,"co_author_invite_id":1774872,"email":"g***z@uchile.cl","display_order":6291456,"name":"Gilberto Sánchez","title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers"},{"id":7949079,"work_id":17277897,"tagging_user_id":36925655,"tagged_user_id":57666903,"co_author_invite_id":1774874,"email":"r***z@vtr.net","display_order":7340032,"name":"Rodrigo Diaz Sanhueza","title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers"},{"id":7949114,"work_id":17277897,"tagging_user_id":36925655,"tagged_user_id":58382834,"co_author_invite_id":1750996,"email":"r***1@gmail.com","display_order":7864320,"name":"Roberto Rodriguez","title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers"},{"id":7949120,"work_id":17277897,"tagging_user_id":36925655,"tagged_user_id":34771516,"co_author_invite_id":null,"email":"j***r@unam.mx","display_order":8126464,"name":"Juan Fernandez-ruiz","title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers"},{"id":7949123,"work_id":17277897,"tagging_user_id":36925655,"tagged_user_id":32842886,"co_author_invite_id":null,"email":"r***e@nih.gov","display_order":8257536,"name":"Raphael Schiffmann","title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers"}],"downloadable_attachments":[{"id":42274408,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42274408/thumbnails/1.jpg","file_name":"Motor_Decline_in_Clinically_Presymptomat20160207-29585-17vxq09.pdf","download_url":"https://www.academia.edu/attachments/42274408/download_file","bulk_download_file_name":"Motor_Decline_in_Clinically_Presymptomat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42274408/Motor_Decline_in_Clinically_Presymptomat20160207-29585-17vxq09-libre.pdf?1454839008=\u0026response-content-disposition=attachment%3B+filename%3DMotor_Decline_in_Clinically_Presymptomat.pdf\u0026Expires=1738802363\u0026Signature=evnxTzXlMfekAHmcLVUM4ej8nRNN0cQCZRt3qfeA8SCqz6MB9kKPnKZ4B3jjCosv1f-ag7evO0EzwEMfCYdliZTCjbVkHfTYcL6UQjsZayUP9rqeZmPXCYY6UUNOC4wxQWWwEuDLj5z8AM8VoH5FSSu8-E-HFxf68b--doJ5qQvQRYNGyC2YtAAyLKw0jtB7N5xBOEHtgbUccu6NX-YUBGIjLoA67APAJGCra9QUs52T8Oz5QV4ybBYarTuGI53h5lmvdDvxdTvTLNfSreI0rNOvnSE1-b8hoWiSNzXv3uJLQ20VC8c-eYbmlwZKAborfBodcYytMJI2aBgVhBSNVA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Motor_Decline_in_Clinically_Presymptomatic_Spinocerebellar_Ataxia_Type_2_Gene_Carriers","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"Background: Motor deficits are a critical component of the clinical characteristics of patients with spinocerebellar ataxia type 2. 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To further understand and characterize the onset of the clinical manifestation in this disease, we tested presymptomatic spinocerebellar ataxia type 2 gene carriers, and volunteers, in a task that evaluates their motor performance and their motor learning capabilities.","owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[{"id":42274408,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42274408/thumbnails/1.jpg","file_name":"Motor_Decline_in_Clinically_Presymptomat20160207-29585-17vxq09.pdf","download_url":"https://www.academia.edu/attachments/42274408/download_file","bulk_download_file_name":"Motor_Decline_in_Clinically_Presymptomat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42274408/Motor_Decline_in_Clinically_Presymptomat20160207-29585-17vxq09-libre.pdf?1454839008=\u0026response-content-disposition=attachment%3B+filename%3DMotor_Decline_in_Clinically_Presymptomat.pdf\u0026Expires=1738802363\u0026Signature=evnxTzXlMfekAHmcLVUM4ej8nRNN0cQCZRt3qfeA8SCqz6MB9kKPnKZ4B3jjCosv1f-ag7evO0EzwEMfCYdliZTCjbVkHfTYcL6UQjsZayUP9rqeZmPXCYY6UUNOC4wxQWWwEuDLj5z8AM8VoH5FSSu8-E-HFxf68b--doJ5qQvQRYNGyC2YtAAyLKw0jtB7N5xBOEHtgbUccu6NX-YUBGIjLoA67APAJGCra9QUs52T8Oz5QV4ybBYarTuGI53h5lmvdDvxdTvTLNfSreI0rNOvnSE1-b8hoWiSNzXv3uJLQ20VC8c-eYbmlwZKAborfBodcYytMJI2aBgVhBSNVA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4116,"name":"Motor Learning","url":"https://www.academia.edu/Documents/in/Motor_Learning"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":541557,"name":"Motor Performance","url":"https://www.academia.edu/Documents/in/Motor_Performance"},{"id":1489115,"name":"Age of Onset","url":"https://www.academia.edu/Documents/in/Age_of_Onset"},{"id":1756573,"name":"Motor Skills","url":"https://www.academia.edu/Documents/in/Motor_Skills"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"}],"urls":[{"id":6494183,"url":"https://www.researchgate.net/profile/Juan_Fernandez-Ruiz/publication/24376667_Motor_Decline_in_Clinically_Presymptomatic_Spinocerebellar_Ataxia_Type_2_Gene_Carriers/links/0046351b5eec33d89a000000.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355863"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17355863/Parahippocampal_gray_matter_alterations_in_Spinocerebellar_Ataxia_Type_2_identified_by_voxel_based_morphometry"><img alt="Research paper thumbnail of Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17355863/Parahippocampal_gray_matter_alterations_in_Spinocerebellar_Ataxia_Type_2_identified_by_voxel_based_morphometry">Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MariecatherineBoll">Marie-catherine Boll</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://unam1.academia.edu/ErickPasaye">Erick Pasaye</a></span></div><div class="wp-workCard_item"><span>Journal of the Neurological Sciences</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355863"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355863"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355863; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355863]").text(description); $(".js-view-count[data-work-id=17355863]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355863; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355863']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17355863]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355863,"title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry","translated_title":"","metadata":{"abstract":"Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of the Neurological Sciences"},"translated_abstract":"Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients.","internal_url":"https://www.academia.edu/17355863/Parahippocampal_gray_matter_alterations_in_Spinocerebellar_Ataxia_Type_2_identified_by_voxel_based_morphometry","translated_internal_url":"","created_at":"2015-10-27T10:48:09.903-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37081080,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8084731,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1306596,"email":"j***r@servidor.unam.mx","display_order":0,"name":"Juan Fernández-ruiz","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084737,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1806764,"email":"v***a@yahoo.com.mx","display_order":4194304,"name":"Victor Galvez","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084741,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":53224552,"co_author_invite_id":1806765,"email":"x***l@hotmail.com","display_order":6291456,"name":"Roberto Emmanuele Mercadillo","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084762,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":37400685,"co_author_invite_id":1806773,"email":"b***r@gmail.com","display_order":7340032,"name":"Marie-catherine Boll","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084767,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1806776,"email":"r***z@iciter.com","display_order":7864320,"name":"Carlos Hernandez-castillo","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084770,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":37222640,"co_author_invite_id":1806777,"email":"p***c@hotmail.com","affiliation":"UNAM Universidad Nacional Autónoma de México","display_order":8126464,"name":"Erick Pasaye","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"}],"downloadable_attachments":[],"slug":"Parahippocampal_gray_matter_alterations_in_Spinocerebellar_Ataxia_Type_2_identified_by_voxel_based_morphometry","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients.","owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[],"research_interests":[{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":314162,"name":"Psychological Tests","url":"https://www.academia.edu/Documents/in/Psychological_Tests"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1250577,"name":"Gray Matter","url":"https://www.academia.edu/Documents/in/Gray_Matter"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355862"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17355862/Olfactory_performance_in_spinocerebellar_ataxia_type_7_patients"><img alt="Research paper thumbnail of Olfactory performance in spinocerebellar ataxia type 7 patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17355862/Olfactory_performance_in_spinocerebellar_ataxia_type_7_patients">Olfactory performance in spinocerebellar ataxia type 7 patients</a></div><div class="wp-workCard_item"><span>Parkinsonism & Related Disorders</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A large body of evidence has shown olfactory deficits in many neurodegenerative diseases. However...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A large body of evidence has shown olfactory deficits in many neurodegenerative diseases. However, the nature of the olfactory impairment remains poorly understood partly because the majority of studies have only explored smell identification capabilities. The purpose of the present study was twofold. First we wanted to test if patients with spinocerebellar ataxia type 7 (SCA7), a progressive neurodegenerative disorder characterized by cerebellar ataxia and visual loss, also have olfactory deficits. Secondly, we wanted to test the nature of the olfactory deficits by testing not only the identification level but also olfactory threshold and discrimination. Based on the olfactory dysfunction found in different neurodegenerative diseases and functional neuroimaging data showing cerebellar activation during olfaction, we hypothesized that SCA7 patients would show an olfactory impairment. To test this hypothesis we studied twenty-eight genetically confirmed SCA7 patients and twenty-seven matched controls using the Sniffing Sticks Test and the University of Pennsylvania Smell Identification Test (UPSIT). The results show that SCA7 patients&amp;amp;amp;amp;amp;amp;amp;#39; ability to discriminate and identify odors is significantly impaired, although their odor detection thresholds were at normal levels. These results suggest that SCA7 neurological damage affects olfactory perception but spares the patients&amp;amp;amp;amp;amp;amp;amp;#39; olfactory sensory capabilities.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355862"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355862"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355862; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355860"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355860/Prism_adaptation_in_spinocerebellar_ataxia_type_2"><img alt="Research paper thumbnail of Prism adaptation in spinocerebellar ataxia type 2" class="work-thumbnail" src="https://attachments.academia-assets.com/39464189/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355860/Prism_adaptation_in_spinocerebellar_ataxia_type_2">Prism adaptation in spinocerebellar ataxia type 2</a></div><div class="wp-workCard_item"><span>Neuropsychologia</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Patients with spinocerebellar ataxia type 2 (SCA2), develop severe pontine nuclei, inferior olive...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Patients with spinocerebellar ataxia type 2 (SCA2), develop severe pontine nuclei, inferior olives, and Purkinje cell degeneration. This form of autosomal dominant cerebellar ataxia is accompanied by progressive ataxia and dysarthria. Although the motor dysfunction is well characterized in these patients, nothing is known about their motor learning capabilities. Here we tested 43 SCA2 patients and their matched controls in prism adaptation, a kind of visuomotor learning task. Our results show that their pattern of brain damage does not entirely disrupt motor learning. Rather, patients had impaired adaptation decrement, but surprisingly a normal aftereffect. Moreover, the mutation degree could discriminate the degree of adaptation. This pattern could reflect the net contribution of two adaptive mechanisms: strategic control and spatial realignment. Accordingly, SCA2 patients show an impaired strategic control that affects the adaptation rate, but a normal spatial realignment measured through the aftereffect. Our results suggest that the neural areas subserving spatial realignment are spared in this form of spinocerebellar ataxia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f535101df2335916e1bd6ff939bb3e6d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464189,"asset_id":17355860,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464189/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355860"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355860"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355860; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355860]").text(description); $(".js-view-count[data-work-id=17355860]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355860; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355860']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277891"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17277891/Progression_markers_of_Spinocerebellar_Ataxia_2_A_twenty_years_neurophysiological_follow_up_study"><img alt="Research paper thumbnail of Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17277891/Progression_markers_of_Spinocerebellar_Ataxia_2_A_twenty_years_neurophysiological_follow_up_study">Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>Journal of the Neurological Sciences</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset of the disease, but there is no information regarding its progression to the final stage of SCA2. In order to study the progression patterns of nerve conduction abnormalities in SCA2 we performed a prospective follow up evaluation of sensory and motor conduction in 21 SCA2 mutation carriers-initially presymptomatics- and 19 non-SCA2 mutation carriers during 20years. The earliest electrophysiological alterations were the reduction of sensory amplitudes in median and sural nerves, which could be found 8 to 5years prior disease onset and in the last 4years of the preclinical stage respectively. These abnormalities were followed by the increase of sensory latencies and decrease of conduction velocities. Sensory amplitudes progressively decreased during the follow-up clinical stage, rendering almost all patients with abnormal amplitudes and lack of sensory potentials, with faster progression rates in patients with larger CAG repeat lengths. Peripheral motor nerves showed the later involvement. These findings were used to define three distinct stages that describe the progression of the peripheral neuropathy. We suggest that sensory amplitudes could be useful biomarkers to assess the progression of peripheral nerve involvement and therefore to evaluate future clinical trials of therapeutic agents.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277891"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277891"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277891; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277891]").text(description); $(".js-view-count[data-work-id=17277891]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277891; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277891']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17277891]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277891,"title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study","translated_title":"","metadata":{"abstract":"Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset of the disease, but there is no information regarding its progression to the final stage of SCA2. In order to study the progression patterns of nerve conduction abnormalities in SCA2 we performed a prospective follow up evaluation of sensory and motor conduction in 21 SCA2 mutation carriers-initially presymptomatics- and 19 non-SCA2 mutation carriers during 20years. The earliest electrophysiological alterations were the reduction of sensory amplitudes in median and sural nerves, which could be found 8 to 5years prior disease onset and in the last 4years of the preclinical stage respectively. These abnormalities were followed by the increase of sensory latencies and decrease of conduction velocities. Sensory amplitudes progressively decreased during the follow-up clinical stage, rendering almost all patients with abnormal amplitudes and lack of sensory potentials, with faster progression rates in patients with larger CAG repeat lengths. Peripheral motor nerves showed the later involvement. These findings were used to define three distinct stages that describe the progression of the peripheral neuropathy. We suggest that sensory amplitudes could be useful biomarkers to assess the progression of peripheral nerve involvement and therefore to evaluate future clinical trials of therapeutic agents.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of the Neurological Sciences"},"translated_abstract":"Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset of the disease, but there is no information regarding its progression to the final stage of SCA2. In order to study the progression patterns of nerve conduction abnormalities in SCA2 we performed a prospective follow up evaluation of sensory and motor conduction in 21 SCA2 mutation carriers-initially presymptomatics- and 19 non-SCA2 mutation carriers during 20years. The earliest electrophysiological alterations were the reduction of sensory amplitudes in median and sural nerves, which could be found 8 to 5years prior disease onset and in the last 4years of the preclinical stage respectively. These abnormalities were followed by the increase of sensory latencies and decrease of conduction velocities. Sensory amplitudes progressively decreased during the follow-up clinical stage, rendering almost all patients with abnormal amplitudes and lack of sensory potentials, with faster progression rates in patients with larger CAG repeat lengths. Peripheral motor nerves showed the later involvement. These findings were used to define three distinct stages that describe the progression of the peripheral neuropathy. We suggest that sensory amplitudes could be useful biomarkers to assess the progression of peripheral nerve involvement and therefore to evaluate future clinical trials of therapeutic agents.","internal_url":"https://www.academia.edu/17277891/Progression_markers_of_Spinocerebellar_Ataxia_2_A_twenty_years_neurophysiological_follow_up_study","translated_internal_url":"","created_at":"2015-10-25T09:31:13.828-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36925655,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":7949005,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":null,"co_author_invite_id":1774862,"email":"l***6@yahoo.com","display_order":0,"name":"Luis Almaguer-mederos","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"},{"id":7949055,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":37081080,"co_author_invite_id":1774868,"email":"d***4@hotmail.com","affiliation":"Universidad Nacional Autónoma de México","display_order":4194304,"name":"Rosalinda Díaz","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"},{"id":7949072,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":null,"co_author_invite_id":1774870,"email":"j***o@vtr.net","display_order":6291456,"name":"Jacqueline Montero","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"},{"id":7949111,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":58382834,"co_author_invite_id":1750996,"email":"r***1@gmail.com","display_order":7340032,"name":"Roberto Rodriguez","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"},{"id":7949119,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":34771516,"co_author_invite_id":null,"email":"j***r@unam.mx","display_order":7864320,"name":"Juan Fernandez-ruiz","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"}],"downloadable_attachments":[],"slug":"Progression_markers_of_Spinocerebellar_Ataxia_2_A_twenty_years_neurophysiological_follow_up_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset of the disease, but there is no information regarding its progression to the final stage of SCA2. In order to study the progression patterns of nerve conduction abnormalities in SCA2 we performed a prospective follow up evaluation of sensory and motor conduction in 21 SCA2 mutation carriers-initially presymptomatics- and 19 non-SCA2 mutation carriers during 20years. The earliest electrophysiological alterations were the reduction of sensory amplitudes in median and sural nerves, which could be found 8 to 5years prior disease onset and in the last 4years of the preclinical stage respectively. These abnormalities were followed by the increase of sensory latencies and decrease of conduction velocities. Sensory amplitudes progressively decreased during the follow-up clinical stage, rendering almost all patients with abnormal amplitudes and lack of sensory potentials, with faster progression rates in patients with larger CAG repeat lengths. Peripheral motor nerves showed the later involvement. These findings were used to define three distinct stages that describe the progression of the peripheral neuropathy. We suggest that sensory amplitudes could be useful biomarkers to assess the progression of peripheral nerve involvement and therefore to evaluate future clinical trials of therapeutic agents.","owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[],"research_interests":[{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia"},{"id":119665,"name":"Reaction Time","url":"https://www.academia.edu/Documents/in/Reaction_Time"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":267085,"name":"Peripheral Neuropathy","url":"https://www.academia.edu/Documents/in/Peripheral_Neuropathy"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":509434,"name":"Peripheral Nerve","url":"https://www.academia.edu/Documents/in/Peripheral_Nerve"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression"},{"id":585241,"name":"Conduction Velocity","url":"https://www.academia.edu/Documents/in/Conduction_Velocity"},{"id":826771,"name":"Electrodiagnosis","url":"https://www.academia.edu/Documents/in/Electrodiagnosis"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1292780,"name":"Median Nerve","url":"https://www.academia.edu/Documents/in/Median_Nerve"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277890"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17277890/Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases"><img alt="Research paper thumbnail of Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases" class="work-thumbnail" src="https://attachments.academia-assets.com/42274407/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17277890/Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases">Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RDruckercol%C3%ADnc">R. Drucker-colínc</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>Journal of Neurology</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5017a3a551d6ab9fe668b5a6b5becf2d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42274407,"asset_id":17277890,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42274407/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277890"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277890"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277890; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277890]").text(description); $(".js-view-count[data-work-id=17277890]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277890; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277890']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5017a3a551d6ab9fe668b5a6b5becf2d" } } $('.js-work-strip[data-work-id=17277890]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277890,"title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases","translated_title":"","metadata":{"ai_abstract":"Olfactory function is affected in different neurodegenerative diseases. Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxias. In the present article the effect of spinocerebellar ataxia type 2 (SCA2) on olfactory function was studied in 53 SCA2 patients and 53 healthy control subjects from Holguín, Cuba. Several tests were applied to evaluate olfactory threshold, description, identification and discrimination. The results show significant impairment in SCA2 patients on all olfactory measurements, and the pattern of olfactory deficits found suggests that they have much in common with those reported for other neurodegenerative diseases such as Parkinson's and Alzheimer's diseases.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Journal of Neurology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/17277890/Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases","translated_internal_url":"","created_at":"2015-10-25T09:31:13.736-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36925655,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":7949052,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":37081080,"co_author_invite_id":1774868,"email":"d***4@hotmail.com","affiliation":"Universidad Nacional Autónoma de México","display_order":0,"name":"Rosalinda Díaz","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"},{"id":7949063,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":null,"co_author_invite_id":1774869,"email":"r***a@hotmail.com","display_order":4194304,"name":"Ruth González","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"},{"id":7949066,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":12137339,"co_author_invite_id":null,"email":"c***o@gmail.com","display_order":6291456,"name":"Gilberto Campos Cruz","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"},{"id":7949070,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":37075934,"co_author_invite_id":197805,"email":"d***r@servidor.unam.mx","display_order":7340032,"name":"R. Drucker-colínc","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"},{"id":7949118,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":34771516,"co_author_invite_id":null,"email":"j***r@unam.mx","display_order":7864320,"name":"Juan Fernandez-ruiz","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"}],"downloadable_attachments":[{"id":42274407,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42274407/thumbnails/1.jpg","file_name":"Spinocerebellar_ataxia_type_2_olfactory_20160207-4681-7x5z58.pdf","download_url":"https://www.academia.edu/attachments/42274407/download_file","bulk_download_file_name":"Spinocerebellar_ataxia_type_2_olfactory.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42274407/Spinocerebellar_ataxia_type_2_olfactory_20160207-4681-7x5z58-libre.pdf?1454839007=\u0026response-content-disposition=attachment%3B+filename%3DSpinocerebellar_ataxia_type_2_olfactory.pdf\u0026Expires=1738802364\u0026Signature=B5aYocT6J9bTo22oQgXPdPwJt6jDnB4gFEXdogXuJTk2THljss1J1PSIaWcXJBgD47pYStdrKBlfxLOrEaC8FyvDoENDrJs2P7xjV0FAS-w5mUy8TbP0p2bJVGciSbx4gdmtb~Zp-RcLjn4OwutMcLLvtymA8DWrGi2LIUShny~ZYg~HsVv7vlrG0TQQuWrROEkfJSxvTyvZQvaTZhmHwjxl0W~OHNFZQhVX~oB6u2i~1dLh4-~jTix6SdOYarUsM05jUvJr7lty5Hfv6WeuPnk1kmTdJXk1iDIkAMrGKU4XnIEtapdvW05LSI3WfD5q3hRjyrJr7-Q8yxb6BLQajA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":null,"owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[{"id":42274407,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42274407/thumbnails/1.jpg","file_name":"Spinocerebellar_ataxia_type_2_olfactory_20160207-4681-7x5z58.pdf","download_url":"https://www.academia.edu/attachments/42274407/download_file","bulk_download_file_name":"Spinocerebellar_ataxia_type_2_olfactory.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42274407/Spinocerebellar_ataxia_type_2_olfactory_20160207-4681-7x5z58-libre.pdf?1454839007=\u0026response-content-disposition=attachment%3B+filename%3DSpinocerebellar_ataxia_type_2_olfactory.pdf\u0026Expires=1738802364\u0026Signature=B5aYocT6J9bTo22oQgXPdPwJt6jDnB4gFEXdogXuJTk2THljss1J1PSIaWcXJBgD47pYStdrKBlfxLOrEaC8FyvDoENDrJs2P7xjV0FAS-w5mUy8TbP0p2bJVGciSbx4gdmtb~Zp-RcLjn4OwutMcLLvtymA8DWrGi2LIUShny~ZYg~HsVv7vlrG0TQQuWrROEkfJSxvTyvZQvaTZhmHwjxl0W~OHNFZQhVX~oB6u2i~1dLh4-~jTix6SdOYarUsM05jUvJr7lty5Hfv6WeuPnk1kmTdJXk1iDIkAMrGKU4XnIEtapdvW05LSI3WfD5q3hRjyrJr7-Q8yxb6BLQajA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology"},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases"},{"id":65927,"name":"Susan Moller Okin","url":"https://www.academia.edu/Documents/in/Susan_Moller_Okin"},{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":527780,"name":"Neurodegenerative Disease","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Disease"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":6494182,"url":"https://www.researchgate.net/profile/Juan_Fernandez-Ruiz/publication/7169991_Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases/links/0c960522f868dbcbfa000000.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355859"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355859/Normal_prism_adaptation_but_reduced_after_effect_in_basal_ganglia_disorders_using_a_throwing_task"><img alt="Research paper thumbnail of Normal prism adaptation but reduced after-effect in basal ganglia disorders using a throwing task" class="work-thumbnail" src="https://attachments.academia-assets.com/39464182/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355859/Normal_prism_adaptation_but_reduced_after_effect_in_basal_ganglia_disorders_using_a_throwing_task">Normal prism adaptation but reduced after-effect in basal ganglia disorders using a throwing task</a></div><div class="wp-workCard_item"><span>European Journal of Neuroscience</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prism adaptation is a form of visuomotor learning in which the visual and motor systems need to b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prism adaptation is a form of visuomotor learning in which the visual and motor systems need to be adjusted because a visual perturbation is produced by horizontally displacing prisms. Despite being known for over two centuries, the neuronal substrates of this phenomenon are not yet completely understood. In this article the possible role of the basal ganglia in this kind of learning was analysed through a study of Huntington's and Parkinson's disease patients. A throwing technique requiring the use of open loop feedback was used. The variables analysed were visuomotor performance, adaptation rate and magnitude, and the after-effect. The results clearly showed that both Huntington's and Parkinson's disease groups learned at the same rate as control subjects. In addition, despite having a disturbed visuomotor performance, both experimental groups showed the same adaptation magnitude as the control group. Finally, the after-effect, which is measured after removing the prisms, is reduced in both patients groups. This reduction leads to a disruption in the normal adaptation±after-effect correlation found in normal volunteers. These results suggest that basal ganglia are not involved in this type of open-looped visuomotor learning. The large number of patients studied as well as the similarity of the ®ndings between both populations support this hypothesis. By contrast, there is an impairment in the after-effect on both basal ganglia patient populations. This impairment may be the result of the deterioration of the perceptual recalibration process involved in visuomotor learning.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9406004a97ac56a1453b99d72686587b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464182,"asset_id":17355859,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464182/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355859"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355859"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355859; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355859]").text(description); $(".js-view-count[data-work-id=17355859]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355859; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355859']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9406004a97ac56a1453b99d72686587b" } } $('.js-work-strip[data-work-id=17355859]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355859,"title":"Normal prism adaptation but reduced after-effect in basal ganglia disorders using a throwing task","translated_title":"","metadata":{"grobid_abstract":"Prism adaptation is a form of visuomotor learning in which the visual and motor systems need to be adjusted because a visual perturbation is produced by horizontally displacing prisms. 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One of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Gender differences have been shown across many domains, and motor skills are no exception. One of the most robust findings is a significant sex difference in throwing accuracy, which reflects the advantage of men in targeting abilities. However, little is known about the basis of this difference. To try to dissect possible mechanisms involved in this difference, here we tested for gender variations in a prism adaptation throwing task. We tested 154 subjects in a visuomotor prism adaptation task that discriminates between motor performance, visuomotor adaptation and negative aftereffects. Our results corroborate men's significant better throwing accuracy, although there were no adaptation differences between genders. In contrast, women showed significant larger negative aftereffects, which could be explained by a larger contribution of spatial alignment. These results suggest that different learning mechanisms, like strategic calibration and spatial alignment, may have different contributions in men and women.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aa8e835b5a7d480933ba36738ef59a3d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464183,"asset_id":17355858,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464183/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355858"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355858"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355858; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355858]").text(description); $(".js-view-count[data-work-id=17355858]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355858; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355858']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aa8e835b5a7d480933ba36738ef59a3d" } } $('.js-work-strip[data-work-id=17355858]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355858,"title":"Sex-related differences in motor learning and performance","translated_title":"","metadata":{"grobid_abstract":"Gender differences have been shown across many domains, and motor skills are no exception. 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These results suggest that different learning mechanisms, like strategic calibration and spatial alignment, may have different contributions in men and women.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Behavioral and Brain Functions","grobid_abstract_attachment_id":39464183},"translated_abstract":null,"internal_url":"https://www.academia.edu/17355858/Sex_related_differences_in_motor_learning_and_performance","translated_internal_url":"","created_at":"2015-10-27T10:48:03.730-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37081080,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8084724,"work_id":17355858,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1306596,"email":"j***r@servidor.unam.mx","display_order":0,"name":"Juan Fernández-ruiz","title":"Sex-related differences in motor learning and performance"}],"downloadable_attachments":[{"id":39464183,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39464183/thumbnails/1.jpg","file_name":"Sex-related_differences_in_motor_learnin20151027-6956-160dc8z.pdf","download_url":"https://www.academia.edu/attachments/39464183/download_file","bulk_download_file_name":"Sex_related_differences_in_motor_learnin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39464183/Sex-related_differences_in_motor_learnin20151027-6956-160dc8z-libre.pdf?1445971769=\u0026response-content-disposition=attachment%3B+filename%3DSex_related_differences_in_motor_learnin.pdf\u0026Expires=1738802364\u0026Signature=aGAM1F3S4wIxmzWE4B4q218mfqkj5rSKiOxBz0sEf9ICJCaK4xI8YyDGxLLSnmg0A07StWZxwFmd5957q2zTK1ayhKkWN3Q3pX4EQUsmAH0wDa0EBHtsbuFoxtSUU~dBtM1xLOihHSGx5N-u2qK1eZe04oVU6RqCmmt45-timBq~QSkCEquOE1DgxjemXOswtaepnlKMvlKvnPGLusstLH-fy9-6~s0o600B9wl~~npChQvY19ouzTjfDI5mkM9-xAXCgQjW-xpEdgRQ8QPktCXS2pYHl80XeOFhl22n9xFcAC3H8dH2suNvsfzMKnTwOTrk-zv2IQ~zC~o0sJw2uQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sex_related_differences_in_motor_learning_and_performance","translated_slug":"","page_count":4,"language":"en","content_type":"Work","summary":"Gender differences have been shown across many domains, and motor skills are no exception. One of the most robust findings is a significant sex difference in throwing accuracy, which reflects the advantage of men in targeting abilities. However, little is known about the basis of this difference. To try to dissect possible mechanisms involved in this difference, here we tested for gender variations in a prism adaptation throwing task. We tested 154 subjects in a visuomotor prism adaptation task that discriminates between motor performance, visuomotor adaptation and negative aftereffects. Our results corroborate men's significant better throwing accuracy, although there were no adaptation differences between genders. In contrast, women showed significant larger negative aftereffects, which could be explained by a larger contribution of spatial alignment. These results suggest that different learning mechanisms, like strategic calibration and spatial alignment, may have different contributions in men and women.","owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[{"id":39464183,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39464183/thumbnails/1.jpg","file_name":"Sex-related_differences_in_motor_learnin20151027-6956-160dc8z.pdf","download_url":"https://www.academia.edu/attachments/39464183/download_file","bulk_download_file_name":"Sex_related_differences_in_motor_learnin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39464183/Sex-related_differences_in_motor_learnin20151027-6956-160dc8z-libre.pdf?1445971769=\u0026response-content-disposition=attachment%3B+filename%3DSex_related_differences_in_motor_learnin.pdf\u0026Expires=1738802364\u0026Signature=aGAM1F3S4wIxmzWE4B4q218mfqkj5rSKiOxBz0sEf9ICJCaK4xI8YyDGxLLSnmg0A07StWZxwFmd5957q2zTK1ayhKkWN3Q3pX4EQUsmAH0wDa0EBHtsbuFoxtSUU~dBtM1xLOihHSGx5N-u2qK1eZe04oVU6RqCmmt45-timBq~QSkCEquOE1DgxjemXOswtaepnlKMvlKvnPGLusstLH-fy9-6~s0o600B9wl~~npChQvY19ouzTjfDI5mkM9-xAXCgQjW-xpEdgRQ8QPktCXS2pYHl80XeOFhl22n9xFcAC3H8dH2suNvsfzMKnTwOTrk-zv2IQ~zC~o0sJw2uQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":4116,"name":"Motor Learning","url":"https://www.academia.edu/Documents/in/Motor_Learning"},{"id":5359,"name":"Visual perception","url":"https://www.academia.edu/Documents/in/Visual_perception"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":43774,"name":"Learning","url":"https://www.academia.edu/Documents/in/Learning"},{"id":75509,"name":"Sex Difference","url":"https://www.academia.edu/Documents/in/Sex_Difference"},{"id":113812,"name":"Gender Difference","url":"https://www.academia.edu/Documents/in/Gender_Difference"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":318172,"name":"Spatial Behavior","url":"https://www.academia.edu/Documents/in/Spatial_Behavior"},{"id":418627,"name":"Behavioral","url":"https://www.academia.edu/Documents/in/Behavioral"},{"id":541557,"name":"Motor Performance","url":"https://www.academia.edu/Documents/in/Motor_Performance"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1756573,"name":"Motor Skills","url":"https://www.academia.edu/Documents/in/Motor_Skills"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17283054"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17283054/Olfaction_and_neurodegeneration_in_HD"><img alt="Research paper thumbnail of Olfaction and neurodegeneration in HD" class="work-thumbnail" src="https://attachments.academia-assets.com/39430302/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17283054/Olfaction_and_neurodegeneration_in_HD">Olfaction and neurodegeneration in HD</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RafaelFavila">Rafael Favila</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FernandoBarrios9">Fernando Barrios</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a></span></div><div class="wp-workCard_item"><span>NeuroReport</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Olfactory de¢cits are present in many neurodegenerative diseases. It is not known, however, wheth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Olfactory de¢cits are present in many neurodegenerative diseases. It is not known, however, whether the olfactory deterioration is caused by a common neural de¢cit, or whether it is unique to each disease. We report here the e¡ect of degeneration of di¡erent brain structures on olfactory impairment in Huntington's disease as determined by voxel-based morphometric analysis. The structures with the greatest e¡ect on the olfactory de¢cit were the entorhinal cortex, the thalamus, the parahippocampal gyrus, and the caudate nucleus. Although various neuroimaging studies have shown previously that the caudate nucleus is involved in olfaction, this is the ¢rst demonstration that it is related to an olfactory dysfunction in a neurodegenerative disease. The results are discussed in relation to other neurodegenerative diseases. NeuroReport 18:73^76</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a45c591f082561fee7e2bc917dcf1414" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39430302,"asset_id":17283054,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39430302/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17283054"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17283054"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17283054; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17283054]").text(description); $(".js-view-count[data-work-id=17283054]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17283054; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17283054']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a45c591f082561fee7e2bc917dcf1414" } } $('.js-work-strip[data-work-id=17283054]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17283054,"title":"Olfaction and neurodegeneration in HD","translated_title":"","metadata":{"grobid_abstract":"Olfactory de¢cits are present in many neurodegenerative diseases. It is not known, however, whether the olfactory deterioration is caused by a common neural de¢cit, or whether it is unique to each disease. We report here the e¡ect of degeneration of di¡erent brain structures on olfactory impairment in Huntington's disease as determined by voxel-based morphometric analysis. The structures with the greatest e¡ect on the olfactory de¢cit were the entorhinal cortex, the thalamus, the parahippocampal gyrus, and the caudate nucleus. Although various neuroimaging studies have shown previously that the caudate nucleus is involved in olfaction, this is the ¢rst demonstration that it is related to an olfactory dysfunction in a neurodegenerative disease. The results are discussed in relation to other neurodegenerative diseases. NeuroReport 18:73^76","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"NeuroReport","grobid_abstract_attachment_id":39430302},"translated_abstract":null,"internal_url":"https://www.academia.edu/17283054/Olfaction_and_neurodegeneration_in_HD","translated_internal_url":"","created_at":"2015-10-25T12:59:30.010-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36935415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":7957202,"work_id":17283054,"tagging_user_id":36935415,"tagged_user_id":37305239,"co_author_invite_id":826764,"email":"r***a@ge.com","display_order":0,"name":"Rafael Favila","title":"Olfaction and neurodegeneration in HD"},{"id":7957204,"work_id":17283054,"tagging_user_id":36935415,"tagged_user_id":null,"co_author_invite_id":1776725,"email":"a***5@hotmail.com","display_order":4194304,"name":"Maria Alonso","title":"Olfaction and neurodegeneration in HD"},{"id":7957205,"work_id":17283054,"tagging_user_id":36935415,"tagged_user_id":37081080,"co_author_invite_id":1774868,"email":"d***4@hotmail.com","affiliation":"Universidad Nacional Autónoma de México","display_order":6291456,"name":"Rosalinda Díaz","title":"Olfaction and neurodegeneration in HD"},{"id":7957206,"work_id":17283054,"tagging_user_id":36935415,"tagged_user_id":null,"co_author_invite_id":1306596,"email":"j***r@servidor.unam.mx","display_order":7340032,"name":"Juan Fernandez-ruiz","title":"Olfaction and neurodegeneration in HD"}],"downloadable_attachments":[{"id":39430302,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39430302/thumbnails/1.jpg","file_name":"Olfaction_and_neurodegeneration_in_HD20151026-26894-jvoc8g.pdf","download_url":"https://www.academia.edu/attachments/39430302/download_file","bulk_download_file_name":"Olfaction_and_neurodegeneration_in_HD.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39430302/Olfaction_and_neurodegeneration_in_HD20151026-26894-jvoc8g-libre.pdf?1445893298=\u0026response-content-disposition=attachment%3B+filename%3DOlfaction_and_neurodegeneration_in_HD.pdf\u0026Expires=1738802364\u0026Signature=en1gT5VznebYZKEdC~JteDqZrVDuARZsM5qPSiqOpV5NbpFde2IhxpjYenE3VQS0i-DXZKZyoFtJYAJiq~CrdOeMlAEZaA62u9tH3MPqvtE9bQ2~nltgcElLM8a1Ew6BhGUdJe4SwqMGUT82YaoYMbG1dtRXrK7~qmOAne8m7oCwxT8ETUBStVmpDmwMBg42Y8m15nNw8WEUrnZzvMr6EBvicNBG37rdmu1zzQr2YgJSYxz0LohsaPix1w6DkfE7SCr~rugjP3sMJ7Z6Z485Ho7BygSvTkmgRSTlkUBsPRPrjW3dyQ8gnGvmDVE8ZYn90zZrwMdHtZqEekRbSci71Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Olfaction_and_neurodegeneration_in_HD","translated_slug":"","page_count":4,"language":"en","content_type":"Work","summary":"Olfactory de¢cits are present in many neurodegenerative diseases. It is not known, however, whether the olfactory deterioration is caused by a common neural de¢cit, or whether it is unique to each disease. We report here the e¡ect of degeneration of di¡erent brain structures on olfactory impairment in Huntington's disease as determined by voxel-based morphometric analysis. The structures with the greatest e¡ect on the olfactory de¢cit were the entorhinal cortex, the thalamus, the parahippocampal gyrus, and the caudate nucleus. Although various neuroimaging studies have shown previously that the caudate nucleus is involved in olfaction, this is the ¢rst demonstration that it is related to an olfactory dysfunction in a neurodegenerative disease. The results are discussed in relation to other neurodegenerative diseases. NeuroReport 18:73^76","owner":{"id":36935415,"first_name":"Fernando","middle_initials":null,"last_name":"Barrios","page_name":"FernandoBarrios9","domain_name":"independent","created_at":"2015-10-25T12:58:16.994-07:00","display_name":"Fernando Barrios","url":"https://independent.academia.edu/FernandoBarrios9"},"attachments":[{"id":39430302,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39430302/thumbnails/1.jpg","file_name":"Olfaction_and_neurodegeneration_in_HD20151026-26894-jvoc8g.pdf","download_url":"https://www.academia.edu/attachments/39430302/download_file","bulk_download_file_name":"Olfaction_and_neurodegeneration_in_HD.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39430302/Olfaction_and_neurodegeneration_in_HD20151026-26894-jvoc8g-libre.pdf?1445893298=\u0026response-content-disposition=attachment%3B+filename%3DOlfaction_and_neurodegeneration_in_HD.pdf\u0026Expires=1738802364\u0026Signature=en1gT5VznebYZKEdC~JteDqZrVDuARZsM5qPSiqOpV5NbpFde2IhxpjYenE3VQS0i-DXZKZyoFtJYAJiq~CrdOeMlAEZaA62u9tH3MPqvtE9bQ2~nltgcElLM8a1Ew6BhGUdJe4SwqMGUT82YaoYMbG1dtRXrK7~qmOAne8m7oCwxT8ETUBStVmpDmwMBg42Y8m15nNw8WEUrnZzvMr6EBvicNBG37rdmu1zzQr2YgJSYxz0LohsaPix1w6DkfE7SCr~rugjP3sMJ7Z6Z485Ho7BygSvTkmgRSTlkUBsPRPrjW3dyQ8gnGvmDVE8ZYn90zZrwMdHtZqEekRbSci71Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":102416,"name":"Smell","url":"https://www.academia.edu/Documents/in/Smell"},{"id":662721,"name":"Huntington disease","url":"https://www.academia.edu/Documents/in/Huntington_disease"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3859549" id="papers"><div class="js-work-strip profile--work_container" data-work-id="28314758"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/28314758/Disruption_of_visual_and_motor_connectivity_in_spinocerebellar_ataxia_type_7"><img alt="Research paper thumbnail of Disruption of visual and motor connectivity in spinocerebellar ataxia type 7" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/28314758/Disruption_of_visual_and_motor_connectivity_in_spinocerebellar_ataxia_type_7">Disruption of visual and motor connectivity in spinocerebellar ataxia type 7</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LizbethGarcia21">Lizbeth Garcia</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a></span></div><div class="wp-workCard_item"><span>Movement Disorders</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characte...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region-specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel-based morphometry and resting-state fMRI, we studied 26 genetically confirmed SCA7 patients and aged-matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo- and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28314758"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28314758"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28314758; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28314758]").text(description); $(".js-view-count[data-work-id=28314758]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28314758; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28314758']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28314758]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28314758,"title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7","translated_title":"","metadata":{"abstract":"Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region-specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel-based morphometry and resting-state fMRI, we studied 26 genetically confirmed SCA7 patients and aged-matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo- and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Movement Disorders"},"translated_abstract":"Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region-specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel-based morphometry and resting-state fMRI, we studied 26 genetically confirmed SCA7 patients and aged-matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo- and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7.","internal_url":"https://www.academia.edu/28314758/Disruption_of_visual_and_motor_connectivity_in_spinocerebellar_ataxia_type_7","translated_internal_url":"","created_at":"2016-09-07T07:50:39.845-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":45486114,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24113511,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":null,"co_author_invite_id":983726,"email":"w***o@email.unc.edu","display_order":0,"name":"Wei Gao","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113512,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":34771516,"co_author_invite_id":null,"email":"j***r@unam.mx","display_order":4194304,"name":"Juan Fernandez-ruiz","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113513,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":49779173,"co_author_invite_id":null,"email":"y***p@gmail.com","display_order":6291456,"name":"Petra Yescas","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113514,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":null,"co_author_invite_id":1842108,"email":"a***r@gmail.com","display_order":7340032,"name":"Sarael Alcauter","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113515,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":8880361,"co_author_invite_id":null,"email":"g***r@yahoo.com","display_order":7864320,"name":"victor galvez","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113516,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":null,"co_author_invite_id":5369871,"email":"f***a@hotmail.com","display_order":8126464,"name":"Fernando Barrios","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"},{"id":24113517,"work_id":28314758,"tagging_user_id":45486114,"tagged_user_id":37081080,"co_author_invite_id":null,"email":"d***4@hotmail.com","affiliation":"Universidad Nacional Autónoma de México","display_order":8257536,"name":"Rosalinda Díaz","title":"Disruption of visual and motor connectivity in spinocerebellar ataxia type 7"}],"downloadable_attachments":[],"slug":"Disruption_of_visual_and_motor_connectivity_in_spinocerebellar_ataxia_type_7","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder characterized by progressive ataxia and retinal dystrophy. It is caused by a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration and region-specific neocortical atrophy in SCA7 patients. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is still unknown. The aim of this study was to examine functional connectivity abnormalities in areas with significant gray matter atrophy in SCA7 patients and their relationship with number of CAG repeats. Using a combination of voxel-based morphometry and resting-state fMRI, we studied 26 genetically confirmed SCA7 patients and aged-matched healthy controls. In SCA7 patients we found reduced functional interaction between the cerebellum and the middle and superior frontal gyri, disrupted functional connectivity between the visual and motor cortices, and increased functional coordination between atrophied areas of the cerebellum and a range of visual cortical areas compared with healthy controls. The degree of mutation expansion showed a negative effect on both the functional interaction between the right anterior cerebellum and the left superior frontal gyrus and the connectivity between the right anterior cerebellum and left parahippocampal gyrus. We found abnormal functional connectivity patterns, including both hypo- and hyperconnectivity, compared with controls. These abnormal patterns show reasonable association with the severity of gene mutation. Our findings suggest that aberrant changes are prevalent in both motor and visual systems, adding significantly to our understanding of the pathophysiology of SCA7.","owner":{"id":45486114,"first_name":"Lizbeth","middle_initials":null,"last_name":"Garcia","page_name":"LizbethGarcia21","domain_name":"independent","created_at":"2016-03-20T14:16:34.048-07:00","display_name":"Lizbeth Garcia","url":"https://independent.academia.edu/LizbethGarcia21"},"attachments":[],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":43367,"name":"Movement disorders","url":"https://www.academia.edu/Documents/in/Movement_disorders"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":357850,"name":"Atrophy","url":"https://www.academia.edu/Documents/in/Atrophy"},{"id":1257483,"name":"Frontal Lobe","url":"https://www.academia.edu/Documents/in/Frontal_Lobe"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355871"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17355871/Extensive_White_Matter_Alterations_and_Its_Correlations_with_Ataxia_Severity_in_SCA_2_Patients"><img alt="Research paper thumbnail of Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17355871/Extensive_White_Matter_Alterations_and_Its_Correlations_with_Ataxia_Severity_in_SCA_2_Patients">Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Previous studies of SCA2 have revealed significant degeneration of white matter tracts in cerebel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Previous studies of SCA2 have revealed significant degeneration of white matter tracts in cerebellar and cerebral regions. The motor deficit in these patients may be attributable to the degradation of projection fibers associated with the underlying neurodegenerative process. However, this relationship remains unclear. Statistical analysis of diffusion tensor imaging enables an unbiased whole-brain quantitative comparison of the diffusion proprieties of white matter tracts in vivo. Fourteen genetically confirmed SCA2 patients and aged-matched healthy controls participated in the study. Tract-based spatial statistics were performed to analyze structural white matter damage using two different measurements: fractional anisotropy (FA) and mean diffusivity (MD). Significant diffusion differences were correlated with the patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s ataxia impairment. Our analysis revealed decreased FA mainly in the inferior/middle/superior cerebellar peduncles, the bilateral posterior limb of the internal capsule and the bilateral superior corona radiata. Increases in MD were found mainly in cerebellar white matter, medial lemniscus, and middle cerebellar peduncle, among other regions. Clinical impairment measured with the SARA score correlated with FA in superior parietal white matter and bilateral anterior corona radiata. Correlations with MD were found in cerebellar white matter and the middle cerebellar peduncle. Our findings show significant correlations between diffusion measurements in key areas affected in SCA2 and measures of motor impairment, suggesting a disruption of information flow between motor and sensory-integration areas. These findings result in a more comprehensive view of the clinical impact of the white matter degeneration in SCA2.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355871"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355871"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355871; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355871]").text(description); $(".js-view-count[data-work-id=17355871]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355871; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355871']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17355871]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355871,"title":"Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients","internal_url":"https://www.academia.edu/17355871/Extensive_White_Matter_Alterations_and_Its_Correlations_with_Ataxia_Severity_in_SCA_2_Patients","owner_id":37081080,"coauthors_can_edit":true,"owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277902"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17277902/Functional_connectivity_changes_related_to_cognitive_and_motor_performance_in_spinocerebellar_ataxia_type_2"><img alt="Research paper thumbnail of Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2" class="work-thumbnail" src="https://attachments.academia-assets.com/42274414/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17277902/Functional_connectivity_changes_related_to_cognitive_and_motor_performance_in_spinocerebellar_ataxia_type_2">Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PetraYescas">Petra Yescas</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>Movement Disorders</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f4c3bf7f4af44279b828b58681865d7f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42274414,"asset_id":17277902,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42274414/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277902"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277902"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277902; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277902]").text(description); $(".js-view-count[data-work-id=17277902]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277902; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277902']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f4c3bf7f4af44279b828b58681865d7f" } } $('.js-work-strip[data-work-id=17277902]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277902,"title":"Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2","internal_url":"https://www.academia.edu/17277902/Functional_connectivity_changes_related_to_cognitive_and_motor_performance_in_spinocerebellar_ataxia_type_2","owner_id":36925655,"coauthors_can_edit":true,"owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[{"id":42274414,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42274414/thumbnails/1.jpg","file_name":"Functional_connectivity_changes_related_20160207-22903-13lb4jq.pdf","download_url":"https://www.academia.edu/attachments/42274414/download_file","bulk_download_file_name":"Functional_connectivity_changes_related.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42274414/Functional_connectivity_changes_related_20160207-22903-13lb4jq-libre.pdf?1454839007=\u0026response-content-disposition=attachment%3B+filename%3DFunctional_connectivity_changes_related.pdf\u0026Expires=1740145517\u0026Signature=OQoSVhhN-WQrRmuC4BVLitLUk1PW1gQURjKBJ-vssjag6C8iiWE~CA3P44e3MTPGCeXSy1eSShwqJgt1Tyxxycj3g7UkztC7gwgNM948ae~1iMLNEk8Q9A66UKKQvc1i01kMLPG-0~s~ua4ndA~7--wBxvsHbfbKAop-jD8UJ7uDpk1kWDSsvsTtj4Z0dGqnIdc4iMxbsTjG3jqi~7u03T4RhdwdEWEReWWU64SM71j5Zre-MgdVO4m6daUevEt-WT2r9lC3e7H1CXglOAsCpU7~td7yMcXvIOGg3n8ZUfR5U3QUtaF09~MJ1AxxOZrGwutzQ28J6dyrf-wf7~mtkA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355870"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355870/The_Effect_of_Spatial_Working_Memory_Deterioration_on_Strategic_Visuomotor_Learning_across_Aging"><img alt="Research paper thumbnail of The Effect of Spatial Working Memory Deterioration on Strategic Visuomotor Learning across Aging" class="work-thumbnail" src="https://attachments.academia-assets.com/42266015/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355870/The_Effect_of_Spatial_Working_Memory_Deterioration_on_Strategic_Visuomotor_Learning_across_Aging">The Effect of Spatial Working Memory Deterioration on Strategic Visuomotor Learning across Aging</a></div><div class="wp-workCard_item"><span>Behavioural Neurology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective. To evaluate the effect of age-related cognitive changes in a visuomotor learning task ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective. To evaluate the effect of age-related cognitive changes in a visuomotor learning task that depends on strategic control and contrast it with the effect in a task principally depending on visuomotor recalibration. Methods. Participants performed a ball throwing task while donning either a reversing dove prism or a displacement wedge prism, which mainly depend on strategic control or visuomotor recalibration, respectively. Visuomotor performance was then analysed in relation to rule acquisition and reversal, recognition memory, visual memory, spatial planning, and spatial working memory with tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Results. The results confirmed previous works showing a detrimental effect of age on visuomotor learning. The analyses of the cognitive changes observed across age showed that both strategic control and visuomotor recalibration had significant negative correlations only with the number of errors in the spatial working memory task. However, when the effect of aging was controlled, the only significant correlation remaining was between the reversal adaptation magnitude and spatial working memory. Discussion. These results suggest that spatial working memory decline across aging could contribute to age-dependent deterioration in both visuomotor learning processes. However, spatial working memory integrity seems to affect strategic learning decline even after controlling for aging.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dc50fe55a0e55175dd214c24c4c16e1f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42266015,"asset_id":17355870,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42266015/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355870"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355870"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355870; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355868"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355868/Social_and_Cultural_Elements_Associated_with_Neurocognitive_Dysfunctions_in_Spinocerebellar_Ataxia_Type_2_Patients"><img alt="Research paper thumbnail of Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients" class="work-thumbnail" src="https://attachments.academia-assets.com/41885582/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355868/Social_and_Cultural_Elements_Associated_with_Neurocognitive_Dysfunctions_in_Spinocerebellar_Ataxia_Type_2_Patients">Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://uam-xochimilco.academia.edu/LorenaPazparedes">Lorena Paz paredes</a></span></div><div class="wp-workCard_item"><span>Frontiers in Psychiatry</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico. Ethnographic records and photographic and video archives about the quotidian participant's routine were obtained from the patients, their relatives and their caregivers. The information was categorized and interpreted taking into consideration cultural issues and patients' medical files. Our analyses suggest that most of the participants do not understand the nature of the disease and this misunderstanding favors magic and non-medical explanations. Patients' testimonies suggest a decrease in pain perception as well as motor alterations that may be related to interoceptive dysfunctions. Relatives' testimonies indicate patients' lack of social and emotional interests that may be related to frontal, temporal, and cerebellar degeneration. In general, participants use their religious beliefs to deal with the disease and only a few of them trust the health system. Patients and their families are either openly rejected and ignored, tolerated or even helped by their community accordingly to different regional traits. We propose that ethnography can provide social representations to understand the patients' alterations, to formulate neurobiological hypotheses, to develop neurocognitive interventions, and to improve the medical approach to the disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e334dd34ba77b08b5f14b7607547c6a6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41885582,"asset_id":17355868,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41885582/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355868"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355868"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355868; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355868]").text(description); $(".js-view-count[data-work-id=17355868]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355868; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355868']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e334dd34ba77b08b5f14b7607547c6a6" } } $('.js-work-strip[data-work-id=17355868]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355868,"title":"Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients","translated_title":"","metadata":{"grobid_abstract":"Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico. Ethnographic records and photographic and video archives about the quotidian participant's routine were obtained from the patients, their relatives and their caregivers. The information was categorized and interpreted taking into consideration cultural issues and patients' medical files. Our analyses suggest that most of the participants do not understand the nature of the disease and this misunderstanding favors magic and non-medical explanations. Patients' testimonies suggest a decrease in pain perception as well as motor alterations that may be related to interoceptive dysfunctions. Relatives' testimonies indicate patients' lack of social and emotional interests that may be related to frontal, temporal, and cerebellar degeneration. In general, participants use their religious beliefs to deal with the disease and only a few of them trust the health system. Patients and their families are either openly rejected and ignored, tolerated or even helped by their community accordingly to different regional traits. We propose that ethnography can provide social representations to understand the patients' alterations, to formulate neurobiological hypotheses, to develop neurocognitive interventions, and to improve the medical approach to the disease.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Frontiers in Psychiatry","grobid_abstract_attachment_id":41885582},"translated_abstract":null,"internal_url":"https://www.academia.edu/17355868/Social_and_Cultural_Elements_Associated_with_Neurocognitive_Dysfunctions_in_Spinocerebellar_Ataxia_Type_2_Patients","translated_internal_url":"","created_at":"2015-10-27T10:48:14.985-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37081080,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8084734,"work_id":17355868,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1306596,"email":"j***r@servidor.unam.mx","display_order":0,"name":"Juan Fernández-ruiz","title":"Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients"},{"id":8084739,"work_id":17355868,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1806764,"email":"v***a@yahoo.com.mx","display_order":4194304,"name":"Victor Galvez","title":"Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients"},{"id":8084742,"work_id":17355868,"tagging_user_id":37081080,"tagged_user_id":53224552,"co_author_invite_id":1806765,"email":"x***l@hotmail.com","display_order":6291456,"name":"Roberto Emmanuele Mercadillo","title":"Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients"},{"id":8084763,"work_id":17355868,"tagging_user_id":37081080,"tagged_user_id":124501918,"co_author_invite_id":1806774,"email":"h***e@hotmail.com","affiliation":"Universidad Autónoma Metropolitana-Xochimilco","display_order":7340032,"name":"Lorena Paz paredes","title":"Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients"},{"id":8084764,"work_id":17355868,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":311417,"email":"j***m@xanum.uam.mx","display_order":7864320,"name":"Javier Velázquez-moctezuma","title":"Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients"},{"id":8084769,"work_id":17355868,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1806776,"email":"r***z@iciter.com","display_order":8126464,"name":"Carlos Hernandez-castillo","title":"Social and Cultural Elements Associated with Neurocognitive Dysfunctions in Spinocerebellar Ataxia Type 2 Patients"}],"downloadable_attachments":[{"id":41885582,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41885582/thumbnails/1.jpg","file_name":"Social_and_Cultural_Elements_Associated_20160202-30232-7o7o2s.pdf","download_url":"https://www.academia.edu/attachments/41885582/download_file","bulk_download_file_name":"Social_and_Cultural_Elements_Associated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41885582/Social_and_Cultural_Elements_Associated_20160202-30232-7o7o2s-libre.pdf?1454417693=\u0026response-content-disposition=attachment%3B+filename%3DSocial_and_Cultural_Elements_Associated.pdf\u0026Expires=1738743564\u0026Signature=ZsJTHyY24S~08fkZ~otDqcTj-1SMYVRc0fk3CSaO22bG8hz8OWdYjTr0w5jYD6lmwj9KH38PJAMwy4DIsqL~JNFI1OhhymcAF6ueK3jZZ9kQG998wDmnnx~XpW2jPS~1CbtC45rj06YVubWyH-R2WZWeDtmZ5mBaAj3XD-Z6S91lzGUgfAY0yQj7pwqOn0dLVXFnt5WphEFUUD-qtWL8UysqfDBDFMRo9m0M-X-lGOycvsKxz2wZUtamRmFDVX0JA4JPwap7VVXD~0ywLKprlygxXaLMAY02nNXHT-DEg9f~kuLD73p3KEtz20Dy3ZXZJJ0B-mah2LUD7530itf7iQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Social_and_Cultural_Elements_Associated_with_Neurocognitive_Dysfunctions_in_Spinocerebellar_Ataxia_Type_2_Patients","translated_slug":"","page_count":19,"language":"en","content_type":"Work","summary":"Spinocerebellar Ataxia Type 2 (SCA2) is a rare genetic disorder producing cerebellar degeneration and affecting motor abilities. Neuroimaging studies also show neurodegeneration in subcortical and cortical regions related to emotional and social processes. From social neuroscience, it is suggested that motor and social abilities can be influenced by particular cultural dynamics so, culture is fundamental to understand the effect of brain-related alterations. Here, we present the first analysis about the cultural elements related to the SCA2 disorder in 15 patients previously evaluated with neuroimaging and psychometric instruments, and their nuclear relationships distributed in six geographical and cultural regions in Mexico. Ethnographic records and photographic and video archives about the quotidian participant's routine were obtained from the patients, their relatives and their caregivers. The information was categorized and interpreted taking into consideration cultural issues and patients' medical files. Our analyses suggest that most of the participants do not understand the nature of the disease and this misunderstanding favors magic and non-medical explanations. Patients' testimonies suggest a decrease in pain perception as well as motor alterations that may be related to interoceptive dysfunctions. Relatives' testimonies indicate patients' lack of social and emotional interests that may be related to frontal, temporal, and cerebellar degeneration. In general, participants use their religious beliefs to deal with the disease and only a few of them trust the health system. Patients and their families are either openly rejected and ignored, tolerated or even helped by their community accordingly to different regional traits. We propose that ethnography can provide social representations to understand the patients' alterations, to formulate neurobiological hypotheses, to develop neurocognitive interventions, and to improve the medical approach to the disease.","owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[{"id":41885582,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41885582/thumbnails/1.jpg","file_name":"Social_and_Cultural_Elements_Associated_20160202-30232-7o7o2s.pdf","download_url":"https://www.academia.edu/attachments/41885582/download_file","bulk_download_file_name":"Social_and_Cultural_Elements_Associated.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41885582/Social_and_Cultural_Elements_Associated_20160202-30232-7o7o2s-libre.pdf?1454417693=\u0026response-content-disposition=attachment%3B+filename%3DSocial_and_Cultural_Elements_Associated.pdf\u0026Expires=1738743564\u0026Signature=ZsJTHyY24S~08fkZ~otDqcTj-1SMYVRc0fk3CSaO22bG8hz8OWdYjTr0w5jYD6lmwj9KH38PJAMwy4DIsqL~JNFI1OhhymcAF6ueK3jZZ9kQG998wDmnnx~XpW2jPS~1CbtC45rj06YVubWyH-R2WZWeDtmZ5mBaAj3XD-Z6S91lzGUgfAY0yQj7pwqOn0dLVXFnt5WphEFUUD-qtWL8UysqfDBDFMRo9m0M-X-lGOycvsKxz2wZUtamRmFDVX0JA4JPwap7VVXD~0ywLKprlygxXaLMAY02nNXHT-DEg9f~kuLD73p3KEtz20Dy3ZXZJJ0B-mah2LUD7530itf7iQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":6305832,"url":"https://www.researchgate.net/profile/Victor_Galvez2/publication/278018225_Social_and_Cultural_Elements_Associated_with_Neurocognitive_Dysfunctions_in_Spinocerebellar_Ataxia_Type_2_Patients/links/55786b4708aeb6d8c01f156e.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355867"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17355867/Effects_of_aging_on_strategic_based_visuomotor_learning"><img alt="Research paper thumbnail of Effects of aging on strategic-based visuomotor learning" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17355867/Effects_of_aging_on_strategic_based_visuomotor_learning">Effects of aging on strategic-based visuomotor learning</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://uv-mx.academia.edu/LuisBeltranParrazal">Luis Beltran-Parrazal</a></span></div><div class="wp-workCard_item"><span>Brain Research</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There are different kinds of visuomotor learnings. One of the most studied is error-based learnin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There are different kinds of visuomotor learnings. One of the most studied is error-based learning where the information about the sign and magnitude of the error is used to update the motor commands. However, there are other instances where subjects show visuomotor learning even if the use of error sign and magnitude information is precluded. In those instances subjects could be using strategic instead of procedural adaptation mechanisms. Here, we present the results of the effect of aging on visuomotor strategic learning under a reversed error feedback condition, and its contrast with procedural visuomotor learning within the same participants. A number of measures were obtained from a task consisting of throwing clay balls to a target before, during and after wearing lateral displacing or reversing prisms. The displacing prism results show an age dependent decrease on the learning rate that corroborates previous findings. The reversing prism results also show significant adaptation impairment in the aged population. However, decreased reversing learning in the older group was the result of an increase in the number of subjects that could not adapt to the reversing prism, and not on a reduction of the learning capacity of all the individuals of the group. These results suggest a significant deleterious effect of aging on visuomotor strategic learning implementation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355867"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355867"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355867; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355867]").text(description); $(".js-view-count[data-work-id=17355867]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355867; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355867']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17355867]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355867,"title":"Effects of aging on strategic-based visuomotor learning","internal_url":"https://www.academia.edu/17355867/Effects_of_aging_on_strategic_based_visuomotor_learning","owner_id":37081080,"coauthors_can_edit":true,"owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277901"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17277901/Strategy_Use_Planning_and_Rule_Acquisition_Deficits_in_Spinocerebellar_Ataxia_Type_2_Patients"><img alt="Research paper thumbnail of Strategy Use, Planning, and Rule Acquisition Deficits in Spinocerebellar Ataxia Type 2 Patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17277901/Strategy_Use_Planning_and_Rule_Acquisition_Deficits_in_Spinocerebellar_Ataxia_Type_2_Patients">Strategy Use, Planning, and Rule Acquisition Deficits in Spinocerebellar Ataxia Type 2 Patients</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>Journal of the International Neuropsychological Society</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Our goal was to improve spinocerebellar ataxia type 2 (SCA2) cognitive profile characterization b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Our goal was to improve spinocerebellar ataxia type 2 (SCA2) cognitive profile characterization by testing the hypothesis that strategy, planning and rule acquisition capacities are affected in SCA2. Forty one patients with SCA2 were evaluated with the Spatial Working Memory (SWM), the Stockings of Cambridge (SOC), and the Intra-Extra Dimensional Shift (IED) tests of the Executive module of the Cambridge Neuropsychological Testing Automated Battery (CANTAB). Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) from the CANTAB memory module were also assessed to corroborate previous findings. Motor deterioration was measured using the Scale for the Assessment and Rating of Ataxia (SARA). We found significant SCA2 related deficits in strategy, planning, and rule acquisition. Our results also corroborated significant memory deficits in these patients with SCA2. Further analysis also showed that patients with large motor deterioration had poorer associative learning and spatial planning scores. Patients with SCA2 show strategy, planning, and rule acquisition deficits as revealed with the CANTAB battery. These deficits should be noted when planning an effective therapy for these patients. (JINS, 2015, 21, 1-7).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277901"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277901"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277901; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277901]").text(description); $(".js-view-count[data-work-id=17277901]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277901; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277901']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17277901]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277901,"title":"Strategy Use, Planning, and Rule Acquisition Deficits in Spinocerebellar Ataxia Type 2 Patients","internal_url":"https://www.academia.edu/17277901/Strategy_Use_Planning_and_Rule_Acquisition_Deficits_in_Spinocerebellar_Ataxia_Type_2_Patients","owner_id":36925655,"coauthors_can_edit":true,"owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355866"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355866/Gray_and_white_matter_alterations_in_spinocerebellar_ataxia_type_7_An_in_vivo_DTI_and_VBM_study"><img alt="Research paper thumbnail of Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study" class="work-thumbnail" src="https://attachments.academia-assets.com/41884361/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355866/Gray_and_white_matter_alterations_in_spinocerebellar_ataxia_type_7_An_in_vivo_DTI_and_VBM_study">Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study</a></div><div class="wp-workCard_item"><span>NeuroImage</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Spinocerebellar ataxia SCA7 Voxel based morphometry Diffusion tensor imaging Tract-based spatial ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Spinocerebellar ataxia SCA7 Voxel based morphometry Diffusion tensor imaging Tract-based spatial statistics CAG Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder characterized by cerebellar ataxia and visual loss. It is caused by a CAG repeat expansion in the gene encoding the ataxin 7 protein. Visual loss is due to a progressive atrophy of photoreceptor cells that results in macular degeneration in more advanced stages. Initial semiautomatic measures in magnetic resonance imaging (MRI) studies on the brain stem have shown a diminished volume mainly in the cerebellum and pons, while T2 images have shown hyperintensities in transverse fibers at the pons. Neuropathological research, however, has shown more widespread brain damage including loss of myelinated fibers. In this study we decided to take advantage of recent MRI methodological advances to further explore the gray and white matter changes that occur in SCA7 patients. We studied nine genetically confirmed SCA7 patients and their matched controls using voxel based morphometry and tract-based spatial statistics. As expected, we found significant bilateral gray matter volume reductions (p b 0.05, corrected for multiple comparisons) in patients' cerebellar cortex. However, we also found significant bilateral gray matter reductions in pre and postcentral gyrus, inferior and medial frontal, parietal inferior, parahippocampal and occipital cortices. The analysis also showed a decrement in fractional anisotropy (p b 0.05, corrected) of SCA7 patients in the cerebellum's white matter, brainstem, cerebellar and cerebral peduncles, midbrain, anterior and posterior internal capsule, external/extreme capsule, corpus callosum, corona radiata, optical radiations, and the occipital, temporal and frontal lobe's white matter. These results confirm previous evidence of widespread damage beyond the cerebellum and the pons in SCA7 patients. They also confirmed previous results that had been only detectable through neuropathological analyses and, more importantly, identified new regions affected by the disease that previous methods could not detect. These new results could help explain the symptom's spectrum that affects these patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="37ff406c1fbbc0b4628373fb0594bdbd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41884361,"asset_id":17355866,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41884361/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355866"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355866"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355866; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355866]").text(description); $(".js-view-count[data-work-id=17355866]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355866; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355866']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "37ff406c1fbbc0b4628373fb0594bdbd" } } $('.js-work-strip[data-work-id=17355866]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355866,"title":"Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study","translated_title":"","metadata":{"grobid_abstract":"Spinocerebellar ataxia SCA7 Voxel based morphometry Diffusion tensor imaging Tract-based spatial statistics CAG Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder characterized by cerebellar ataxia and visual loss. It is caused by a CAG repeat expansion in the gene encoding the ataxin 7 protein. Visual loss is due to a progressive atrophy of photoreceptor cells that results in macular degeneration in more advanced stages. Initial semiautomatic measures in magnetic resonance imaging (MRI) studies on the brain stem have shown a diminished volume mainly in the cerebellum and pons, while T2 images have shown hyperintensities in transverse fibers at the pons. Neuropathological research, however, has shown more widespread brain damage including loss of myelinated fibers. In this study we decided to take advantage of recent MRI methodological advances to further explore the gray and white matter changes that occur in SCA7 patients. We studied nine genetically confirmed SCA7 patients and their matched controls using voxel based morphometry and tract-based spatial statistics. As expected, we found significant bilateral gray matter volume reductions (p b 0.05, corrected for multiple comparisons) in patients' cerebellar cortex. However, we also found significant bilateral gray matter reductions in pre and postcentral gyrus, inferior and medial frontal, parietal inferior, parahippocampal and occipital cortices. The analysis also showed a decrement in fractional anisotropy (p b 0.05, corrected) of SCA7 patients in the cerebellum's white matter, brainstem, cerebellar and cerebral peduncles, midbrain, anterior and posterior internal capsule, external/extreme capsule, corpus callosum, corona radiata, optical radiations, and the occipital, temporal and frontal lobe's white matter. These results confirm previous evidence of widespread damage beyond the cerebellum and the pons in SCA7 patients. They also confirmed previous results that had been only detectable through neuropathological analyses and, more importantly, identified new regions affected by the disease that previous methods could not detect. These new results could help explain the symptom's spectrum that affects these patients.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"NeuroImage","grobid_abstract_attachment_id":41884361},"translated_abstract":null,"internal_url":"https://www.academia.edu/17355866/Gray_and_white_matter_alterations_in_spinocerebellar_ataxia_type_7_An_in_vivo_DTI_and_VBM_study","translated_internal_url":"","created_at":"2015-10-27T10:48:11.585-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37081080,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8084723,"work_id":17355866,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1806763,"email":"b***s@inb.unam.mx","display_order":0,"name":"Fernando Barrios","title":"Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study"},{"id":8084725,"work_id":17355866,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1306596,"email":"j***r@servidor.unam.mx","display_order":4194304,"name":"Juan Fernández-ruiz","title":"Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study"},{"id":8084744,"work_id":17355866,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1806766,"email":"a***r@inb.unam.mx","display_order":6291456,"name":"Sarael Alcauter","title":"Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study"}],"downloadable_attachments":[{"id":41884361,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41884361/thumbnails/1.jpg","file_name":"Gray_and_white_matter_alterations_in_spi20160202-30232-6e92t3.pdf","download_url":"https://www.academia.edu/attachments/41884361/download_file","bulk_download_file_name":"Gray_and_white_matter_alterations_in_spi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41884361/Gray_and_white_matter_alterations_in_spi20160202-30232-6e92t3-libre.pdf?1454417211=\u0026response-content-disposition=attachment%3B+filename%3DGray_and_white_matter_alterations_in_spi.pdf\u0026Expires=1738743564\u0026Signature=bKXdrh~azfgyvYdntijGrKxGQGRoosBF86dbGryQOR0VJEqLdEF0M1QEDhj9zm8HoUGPaf3lGbeigdcXDKkv-0edpUZu1FoCF4jNOw5sOvONVvOBuTcmvmkJfiI~nQLrhKpOvbHy9I0aTyUTLp8Y0we1SoaMxOmqQe-x0kx-LeFYe~Zcdjh1d71kI0q0KctKVKo2HA3bwVKR00BN0hjsggj-4Psu3aL6o4fX7lIQqZpp8RysnvwfjiQb7597K4~b8gI6SlrO-iNGpbiKu3yU-iPwtsNyKRxZRjncP8ab54EP5zsRgzylRZIyEbHWK~BPxeIN8751mkWaTlKFcF4kDA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Gray_and_white_matter_alterations_in_spinocerebellar_ataxia_type_7_An_in_vivo_DTI_and_VBM_study","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"Spinocerebellar ataxia SCA7 Voxel based morphometry Diffusion tensor imaging Tract-based spatial statistics CAG Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder characterized by cerebellar ataxia and visual loss. It is caused by a CAG repeat expansion in the gene encoding the ataxin 7 protein. Visual loss is due to a progressive atrophy of photoreceptor cells that results in macular degeneration in more advanced stages. Initial semiautomatic measures in magnetic resonance imaging (MRI) studies on the brain stem have shown a diminished volume mainly in the cerebellum and pons, while T2 images have shown hyperintensities in transverse fibers at the pons. Neuropathological research, however, has shown more widespread brain damage including loss of myelinated fibers. In this study we decided to take advantage of recent MRI methodological advances to further explore the gray and white matter changes that occur in SCA7 patients. We studied nine genetically confirmed SCA7 patients and their matched controls using voxel based morphometry and tract-based spatial statistics. As expected, we found significant bilateral gray matter volume reductions (p b 0.05, corrected for multiple comparisons) in patients' cerebellar cortex. However, we also found significant bilateral gray matter reductions in pre and postcentral gyrus, inferior and medial frontal, parietal inferior, parahippocampal and occipital cortices. The analysis also showed a decrement in fractional anisotropy (p b 0.05, corrected) of SCA7 patients in the cerebellum's white matter, brainstem, cerebellar and cerebral peduncles, midbrain, anterior and posterior internal capsule, external/extreme capsule, corpus callosum, corona radiata, optical radiations, and the occipital, temporal and frontal lobe's white matter. These results confirm previous evidence of widespread damage beyond the cerebellum and the pons in SCA7 patients. They also confirmed previous results that had been only detectable through neuropathological analyses and, more importantly, identified new regions affected by the disease that previous methods could not detect. These new results could help explain the symptom's spectrum that affects these patients.","owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[{"id":41884361,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41884361/thumbnails/1.jpg","file_name":"Gray_and_white_matter_alterations_in_spi20160202-30232-6e92t3.pdf","download_url":"https://www.academia.edu/attachments/41884361/download_file","bulk_download_file_name":"Gray_and_white_matter_alterations_in_spi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41884361/Gray_and_white_matter_alterations_in_spi20160202-30232-6e92t3-libre.pdf?1454417211=\u0026response-content-disposition=attachment%3B+filename%3DGray_and_white_matter_alterations_in_spi.pdf\u0026Expires=1738743564\u0026Signature=bKXdrh~azfgyvYdntijGrKxGQGRoosBF86dbGryQOR0VJEqLdEF0M1QEDhj9zm8HoUGPaf3lGbeigdcXDKkv-0edpUZu1FoCF4jNOw5sOvONVvOBuTcmvmkJfiI~nQLrhKpOvbHy9I0aTyUTLp8Y0we1SoaMxOmqQe-x0kx-LeFYe~Zcdjh1d71kI0q0KctKVKo2HA3bwVKR00BN0hjsggj-4Psu3aL6o4fX7lIQqZpp8RysnvwfjiQb7597K4~b8gI6SlrO-iNGpbiKu3yU-iPwtsNyKRxZRjncP8ab54EP5zsRgzylRZIyEbHWK~BPxeIN8751mkWaTlKFcF4kDA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":32913,"name":"Neuroimmunology","url":"https://www.academia.edu/Documents/in/Neuroimmunology"},{"id":40272,"name":"Macular Degeneration","url":"https://www.academia.edu/Documents/in/Macular_Degeneration"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":65614,"name":"Corpus Callosum","url":"https://www.academia.edu/Documents/in/Corpus_Callosum"},{"id":103260,"name":"Neuroimage","url":"https://www.academia.edu/Documents/in/Neuroimage"},{"id":103265,"name":"Voxel Based Morphometry","url":"https://www.academia.edu/Documents/in/Voxel_Based_Morphometry"},{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":146326,"name":"Cerebellar ataxia","url":"https://www.academia.edu/Documents/in/Cerebellar_ataxia"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum"},{"id":362036,"name":"White matter","url":"https://www.academia.edu/Documents/in/White_matter"},{"id":396677,"name":"Multiple comparisons","url":"https://www.academia.edu/Documents/in/Multiple_comparisons"},{"id":497323,"name":"Fractional Anisotropy","url":"https://www.academia.edu/Documents/in/Fractional_Anisotropy"},{"id":1250577,"name":"Gray Matter","url":"https://www.academia.edu/Documents/in/Gray_Matter"},{"id":1431361,"name":"Brain Damage","url":"https://www.academia.edu/Documents/in/Brain_Damage"}],"urls":[{"id":6305059,"url":"https://www.researchgate.net/profile/Juan_Fernandez-Ruiz/publication/49673151_Gray_and_white_matter_alterations_in_spinocerebellar_ataxia_type_7_an_in_vivo_DTI_and_VBM_study/links/5421d9d20cf26120b7a00b92.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355865"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355865/Decay_of_prism_aftereffects_under_passive_and_active_conditions"><img alt="Research paper thumbnail of Decay of prism aftereffects under passive and active conditions" class="work-thumbnail" src="https://attachments.academia-assets.com/39464186/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355865/Decay_of_prism_aftereffects_under_passive_and_active_conditions">Decay of prism aftereffects under passive and active conditions</a></div><div class="wp-workCard_item"><span>Cognitive Brain Research</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In prism adaptation, subjects adapt to new visuospatial coordinates imposed by wedge prisms that ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In prism adaptation, subjects adapt to new visuospatial coordinates imposed by wedge prisms that laterally displace the visual field. During this process, subjects develop and store new visuomotor coordinates in order to compensate for the displacement of visual stimuli. After the prisms are removed, subjects show an aftereffect in the opposite direction of the original perturbation. The aftereffect is a manifestation of the recently stored information. In the present article, we were interested in studying the properties of the aftereffect. Specifically, we investigated the fate of the aftereffect under active conditions with motor reafferences but without visual input, and during passive conditions without visual or motor reafferences. The results in the motor active condition show that motor reafference (proprioceptive or corollary discharge information) led to a faster, but incomplete, aftereffect decay. The results in the passive condition show a bimodal aftereffect behavior, with a fast decay within the initial minutes, followed by a sustained aftereffect up to 20 min later. These data suggests that two different memory processes may contribute to the aftereffect, one showing a fast decay mainly within 1 min, and another that shows a stable endurance for more than 20 min. D 2004 Elsevier B.V. All rights reserved.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e39311c26acecd89cacf028739dd2a94" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464186,"asset_id":17355865,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464186/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355865"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355865"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355865; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355865]").text(description); $(".js-view-count[data-work-id=17355865]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355865; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355865']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277897"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17277897/Motor_Decline_in_Clinically_Presymptomatic_Spinocerebellar_Ataxia_Type_2_Gene_Carriers"><img alt="Research paper thumbnail of Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers" class="work-thumbnail" src="https://attachments.academia-assets.com/42274408/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17277897/Motor_Decline_in_Clinically_Presymptomatic_Spinocerebellar_Ataxia_Type_2_Gene_Carriers">Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Motor deficits are a critical component of the clinical characteristics of patients w...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Motor deficits are a critical component of the clinical characteristics of patients with spinocerebellar ataxia type 2. However, there is no current information on the preclinical manifestation of those motor deficits in presymptomatic gene carriers. To further understand and characterize the onset of the clinical manifestation in this disease, we tested presymptomatic spinocerebellar ataxia type 2 gene carriers, and volunteers, in a task that evaluates their motor performance and their motor learning capabilities.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="50fb795b3bda1fe4d1c82e4214c14769" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42274408,"asset_id":17277897,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42274408/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277897"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277897"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277897; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277897]").text(description); $(".js-view-count[data-work-id=17277897]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277897; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277897']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "50fb795b3bda1fe4d1c82e4214c14769" } } $('.js-work-strip[data-work-id=17277897]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277897,"title":"Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers","translated_title":"","metadata":{"grobid_abstract":"Background: Motor deficits are a critical component of the clinical characteristics of patients with spinocerebellar ataxia type 2. However, there is no current information on the preclinical manifestation of those motor deficits in presymptomatic gene carriers. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355863"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17355863/Parahippocampal_gray_matter_alterations_in_Spinocerebellar_Ataxia_Type_2_identified_by_voxel_based_morphometry"><img alt="Research paper thumbnail of Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17355863/Parahippocampal_gray_matter_alterations_in_Spinocerebellar_Ataxia_Type_2_identified_by_voxel_based_morphometry">Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MariecatherineBoll">Marie-catherine Boll</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://unam1.academia.edu/ErickPasaye">Erick Pasaye</a></span></div><div class="wp-workCard_item"><span>Journal of the Neurological Sciences</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355863"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355863"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355863; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355863]").text(description); $(".js-view-count[data-work-id=17355863]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355863; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355863']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17355863]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355863,"title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry","translated_title":"","metadata":{"abstract":"Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of the Neurological Sciences"},"translated_abstract":"Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients.","internal_url":"https://www.academia.edu/17355863/Parahippocampal_gray_matter_alterations_in_Spinocerebellar_Ataxia_Type_2_identified_by_voxel_based_morphometry","translated_internal_url":"","created_at":"2015-10-27T10:48:09.903-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37081080,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8084731,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1306596,"email":"j***r@servidor.unam.mx","display_order":0,"name":"Juan Fernández-ruiz","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084737,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1806764,"email":"v***a@yahoo.com.mx","display_order":4194304,"name":"Victor Galvez","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084741,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":53224552,"co_author_invite_id":1806765,"email":"x***l@hotmail.com","display_order":6291456,"name":"Roberto Emmanuele Mercadillo","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084762,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":37400685,"co_author_invite_id":1806773,"email":"b***r@gmail.com","display_order":7340032,"name":"Marie-catherine Boll","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084767,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1806776,"email":"r***z@iciter.com","display_order":7864320,"name":"Carlos Hernandez-castillo","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"},{"id":8084770,"work_id":17355863,"tagging_user_id":37081080,"tagged_user_id":37222640,"co_author_invite_id":1806777,"email":"p***c@hotmail.com","affiliation":"UNAM Universidad Nacional Autónoma de México","display_order":8126464,"name":"Erick Pasaye","title":"Parahippocampal gray matter alterations in Spinocerebellar Ataxia Type 2 identified by voxel based morphometry"}],"downloadable_attachments":[],"slug":"Parahippocampal_gray_matter_alterations_in_Spinocerebellar_Ataxia_Type_2_identified_by_voxel_based_morphometry","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Spinocerebellar Ataxia Type 2 (SCA2) is a genetic disorder causing cerebellar degeneration that result in motor and cognitive alterations. Voxel-based morphometry (VBM) analyses have found neurodegenerative patterns associated to SCA2, but they show some discrepancies. Moreover, behavioral deficits related to non-cerebellar functions are scarcely discussed in those reports. In this work we use behavioral and cognitive tests and VBM to identify and confirm cognitive and gray matter alterations in SCA2 patients compared with control subjects. Also, we discuss the cerebellar and non-cerebellar functions affected by this disease. Our results confirmed gray matter reduction in the cerebellar vermis, pons, and insular, frontal, parietal and temporal cortices. However, our analysis also found unreported loss of gray matter in the parahippocampal gyrus bilaterally. Motor performance test ratings correlated with total gray and white matter reductions, but executive performance and clinical features such as CAG repetitions and disease progression did not show any correlation. This pattern of cerebellar and non-cerebellar morphological alterations associated with SCA2 has to be considered to fully understand the motor and non-motor deficits that include language production and comprehension and some social skill changes that occur in these patients.","owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[],"research_interests":[{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":314162,"name":"Psychological Tests","url":"https://www.academia.edu/Documents/in/Psychological_Tests"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1250577,"name":"Gray Matter","url":"https://www.academia.edu/Documents/in/Gray_Matter"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355862"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17355862/Olfactory_performance_in_spinocerebellar_ataxia_type_7_patients"><img alt="Research paper thumbnail of Olfactory performance in spinocerebellar ataxia type 7 patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17355862/Olfactory_performance_in_spinocerebellar_ataxia_type_7_patients">Olfactory performance in spinocerebellar ataxia type 7 patients</a></div><div class="wp-workCard_item"><span>Parkinsonism & Related Disorders</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A large body of evidence has shown olfactory deficits in many neurodegenerative diseases. However...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A large body of evidence has shown olfactory deficits in many neurodegenerative diseases. However, the nature of the olfactory impairment remains poorly understood partly because the majority of studies have only explored smell identification capabilities. The purpose of the present study was twofold. First we wanted to test if patients with spinocerebellar ataxia type 7 (SCA7), a progressive neurodegenerative disorder characterized by cerebellar ataxia and visual loss, also have olfactory deficits. Secondly, we wanted to test the nature of the olfactory deficits by testing not only the identification level but also olfactory threshold and discrimination. Based on the olfactory dysfunction found in different neurodegenerative diseases and functional neuroimaging data showing cerebellar activation during olfaction, we hypothesized that SCA7 patients would show an olfactory impairment. To test this hypothesis we studied twenty-eight genetically confirmed SCA7 patients and twenty-seven matched controls using the Sniffing Sticks Test and the University of Pennsylvania Smell Identification Test (UPSIT). The results show that SCA7 patients&amp;amp;amp;amp;amp;amp;amp;#39; ability to discriminate and identify odors is significantly impaired, although their odor detection thresholds were at normal levels. These results suggest that SCA7 neurological damage affects olfactory perception but spares the patients&amp;amp;amp;amp;amp;amp;amp;#39; olfactory sensory capabilities.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355862"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355862"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355862; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17355862]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355862,"title":"Olfactory performance in spinocerebellar ataxia type 7 patients","internal_url":"https://www.academia.edu/17355862/Olfactory_performance_in_spinocerebellar_ataxia_type_7_patients","owner_id":37081080,"coauthors_can_edit":true,"owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355861"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355861/Olfactory_dysfunction_in_hereditary_ataxia_and_basal_ganglia_disorders"><img alt="Research paper thumbnail of Olfactory dysfunction in hereditary ataxia and basal ganglia disorders" class="work-thumbnail" src="https://attachments.academia-assets.com/39464185/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355861/Olfactory_dysfunction_in_hereditary_ataxia_and_basal_ganglia_disorders">Olfactory dysfunction in hereditary ataxia and basal ganglia disorders</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PetraYescas">Petra Yescas</a></span></div><div class="wp-workCard_item"><span>NeuroReport</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="89396bdbb6ca4f5dcc334cd5622fb1b6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464185,"asset_id":17355861,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464185/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355861"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355861"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355861; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355861]").text(description); $(".js-view-count[data-work-id=17355861]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355861; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355861']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355860"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355860/Prism_adaptation_in_spinocerebellar_ataxia_type_2"><img alt="Research paper thumbnail of Prism adaptation in spinocerebellar ataxia type 2" class="work-thumbnail" src="https://attachments.academia-assets.com/39464189/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355860/Prism_adaptation_in_spinocerebellar_ataxia_type_2">Prism adaptation in spinocerebellar ataxia type 2</a></div><div class="wp-workCard_item"><span>Neuropsychologia</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Patients with spinocerebellar ataxia type 2 (SCA2), develop severe pontine nuclei, inferior olive...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Patients with spinocerebellar ataxia type 2 (SCA2), develop severe pontine nuclei, inferior olives, and Purkinje cell degeneration. This form of autosomal dominant cerebellar ataxia is accompanied by progressive ataxia and dysarthria. Although the motor dysfunction is well characterized in these patients, nothing is known about their motor learning capabilities. Here we tested 43 SCA2 patients and their matched controls in prism adaptation, a kind of visuomotor learning task. Our results show that their pattern of brain damage does not entirely disrupt motor learning. Rather, patients had impaired adaptation decrement, but surprisingly a normal aftereffect. Moreover, the mutation degree could discriminate the degree of adaptation. This pattern could reflect the net contribution of two adaptive mechanisms: strategic control and spatial realignment. Accordingly, SCA2 patients show an impaired strategic control that affects the adaptation rate, but a normal spatial realignment measured through the aftereffect. Our results suggest that the neural areas subserving spatial realignment are spared in this form of spinocerebellar ataxia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f535101df2335916e1bd6ff939bb3e6d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464189,"asset_id":17355860,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464189/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355860"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355860"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355860; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355860]").text(description); $(".js-view-count[data-work-id=17355860]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355860; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355860']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277891"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/17277891/Progression_markers_of_Spinocerebellar_Ataxia_2_A_twenty_years_neurophysiological_follow_up_study"><img alt="Research paper thumbnail of Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/17277891/Progression_markers_of_Spinocerebellar_Ataxia_2_A_twenty_years_neurophysiological_follow_up_study">Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>Journal of the Neurological Sciences</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset of the disease, but there is no information regarding its progression to the final stage of SCA2. In order to study the progression patterns of nerve conduction abnormalities in SCA2 we performed a prospective follow up evaluation of sensory and motor conduction in 21 SCA2 mutation carriers-initially presymptomatics- and 19 non-SCA2 mutation carriers during 20years. The earliest electrophysiological alterations were the reduction of sensory amplitudes in median and sural nerves, which could be found 8 to 5years prior disease onset and in the last 4years of the preclinical stage respectively. These abnormalities were followed by the increase of sensory latencies and decrease of conduction velocities. Sensory amplitudes progressively decreased during the follow-up clinical stage, rendering almost all patients with abnormal amplitudes and lack of sensory potentials, with faster progression rates in patients with larger CAG repeat lengths. Peripheral motor nerves showed the later involvement. These findings were used to define three distinct stages that describe the progression of the peripheral neuropathy. We suggest that sensory amplitudes could be useful biomarkers to assess the progression of peripheral nerve involvement and therefore to evaluate future clinical trials of therapeutic agents.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277891"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277891"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277891; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277891]").text(description); $(".js-view-count[data-work-id=17277891]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277891; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277891']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=17277891]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277891,"title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study","translated_title":"","metadata":{"abstract":"Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset of the disease, but there is no information regarding its progression to the final stage of SCA2. In order to study the progression patterns of nerve conduction abnormalities in SCA2 we performed a prospective follow up evaluation of sensory and motor conduction in 21 SCA2 mutation carriers-initially presymptomatics- and 19 non-SCA2 mutation carriers during 20years. The earliest electrophysiological alterations were the reduction of sensory amplitudes in median and sural nerves, which could be found 8 to 5years prior disease onset and in the last 4years of the preclinical stage respectively. These abnormalities were followed by the increase of sensory latencies and decrease of conduction velocities. Sensory amplitudes progressively decreased during the follow-up clinical stage, rendering almost all patients with abnormal amplitudes and lack of sensory potentials, with faster progression rates in patients with larger CAG repeat lengths. Peripheral motor nerves showed the later involvement. These findings were used to define three distinct stages that describe the progression of the peripheral neuropathy. We suggest that sensory amplitudes could be useful biomarkers to assess the progression of peripheral nerve involvement and therefore to evaluate future clinical trials of therapeutic agents.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of the Neurological Sciences"},"translated_abstract":"Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset of the disease, but there is no information regarding its progression to the final stage of SCA2. In order to study the progression patterns of nerve conduction abnormalities in SCA2 we performed a prospective follow up evaluation of sensory and motor conduction in 21 SCA2 mutation carriers-initially presymptomatics- and 19 non-SCA2 mutation carriers during 20years. The earliest electrophysiological alterations were the reduction of sensory amplitudes in median and sural nerves, which could be found 8 to 5years prior disease onset and in the last 4years of the preclinical stage respectively. These abnormalities were followed by the increase of sensory latencies and decrease of conduction velocities. Sensory amplitudes progressively decreased during the follow-up clinical stage, rendering almost all patients with abnormal amplitudes and lack of sensory potentials, with faster progression rates in patients with larger CAG repeat lengths. Peripheral motor nerves showed the later involvement. These findings were used to define three distinct stages that describe the progression of the peripheral neuropathy. We suggest that sensory amplitudes could be useful biomarkers to assess the progression of peripheral nerve involvement and therefore to evaluate future clinical trials of therapeutic agents.","internal_url":"https://www.academia.edu/17277891/Progression_markers_of_Spinocerebellar_Ataxia_2_A_twenty_years_neurophysiological_follow_up_study","translated_internal_url":"","created_at":"2015-10-25T09:31:13.828-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36925655,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":7949005,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":null,"co_author_invite_id":1774862,"email":"l***6@yahoo.com","display_order":0,"name":"Luis Almaguer-mederos","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"},{"id":7949055,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":37081080,"co_author_invite_id":1774868,"email":"d***4@hotmail.com","affiliation":"Universidad Nacional Autónoma de México","display_order":4194304,"name":"Rosalinda Díaz","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"},{"id":7949072,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":null,"co_author_invite_id":1774870,"email":"j***o@vtr.net","display_order":6291456,"name":"Jacqueline Montero","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"},{"id":7949111,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":58382834,"co_author_invite_id":1750996,"email":"r***1@gmail.com","display_order":7340032,"name":"Roberto Rodriguez","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"},{"id":7949119,"work_id":17277891,"tagging_user_id":36925655,"tagged_user_id":34771516,"co_author_invite_id":null,"email":"j***r@unam.mx","display_order":7864320,"name":"Juan Fernandez-ruiz","title":"Progression markers of Spinocerebellar Ataxia 2. A twenty years neurophysiological follow up study"}],"downloadable_attachments":[],"slug":"Progression_markers_of_Spinocerebellar_Ataxia_2_A_twenty_years_neurophysiological_follow_up_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Nerve conduction is profoundly affected in Spinocerebellar ataxia 2 (SCA2) even before the onset of the disease, but there is no information regarding its progression to the final stage of SCA2. In order to study the progression patterns of nerve conduction abnormalities in SCA2 we performed a prospective follow up evaluation of sensory and motor conduction in 21 SCA2 mutation carriers-initially presymptomatics- and 19 non-SCA2 mutation carriers during 20years. The earliest electrophysiological alterations were the reduction of sensory amplitudes in median and sural nerves, which could be found 8 to 5years prior disease onset and in the last 4years of the preclinical stage respectively. These abnormalities were followed by the increase of sensory latencies and decrease of conduction velocities. Sensory amplitudes progressively decreased during the follow-up clinical stage, rendering almost all patients with abnormal amplitudes and lack of sensory potentials, with faster progression rates in patients with larger CAG repeat lengths. Peripheral motor nerves showed the later involvement. These findings were used to define three distinct stages that describe the progression of the peripheral neuropathy. We suggest that sensory amplitudes could be useful biomarkers to assess the progression of peripheral nerve involvement and therefore to evaluate future clinical trials of therapeutic agents.","owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[],"research_interests":[{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia"},{"id":119665,"name":"Reaction Time","url":"https://www.academia.edu/Documents/in/Reaction_Time"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":267085,"name":"Peripheral Neuropathy","url":"https://www.academia.edu/Documents/in/Peripheral_Neuropathy"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":509434,"name":"Peripheral Nerve","url":"https://www.academia.edu/Documents/in/Peripheral_Nerve"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression"},{"id":585241,"name":"Conduction Velocity","url":"https://www.academia.edu/Documents/in/Conduction_Velocity"},{"id":826771,"name":"Electrodiagnosis","url":"https://www.academia.edu/Documents/in/Electrodiagnosis"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1292780,"name":"Median Nerve","url":"https://www.academia.edu/Documents/in/Median_Nerve"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17277890"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17277890/Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases"><img alt="Research paper thumbnail of Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases" class="work-thumbnail" src="https://attachments.academia-assets.com/42274407/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17277890/Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases">Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuisVelazquezperez">Luis Velazquez-perez</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unam.academia.edu/RosalindaD%C3%ADaz">Rosalinda Díaz</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RDruckercol%C3%ADnc">R. Drucker-colínc</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/JuanFernandezruiz">Juan Fernandez-ruiz</a></span></div><div class="wp-workCard_item"><span>Journal of Neurology</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5017a3a551d6ab9fe668b5a6b5becf2d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42274407,"asset_id":17277890,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42274407/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17277890"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17277890"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17277890; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17277890]").text(description); $(".js-view-count[data-work-id=17277890]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17277890; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17277890']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5017a3a551d6ab9fe668b5a6b5becf2d" } } $('.js-work-strip[data-work-id=17277890]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17277890,"title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases","translated_title":"","metadata":{"ai_abstract":"Olfactory function is affected in different neurodegenerative diseases. Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxias. In the present article the effect of spinocerebellar ataxia type 2 (SCA2) on olfactory function was studied in 53 SCA2 patients and 53 healthy control subjects from Holguín, Cuba. Several tests were applied to evaluate olfactory threshold, description, identification and discrimination. The results show significant impairment in SCA2 patients on all olfactory measurements, and the pattern of olfactory deficits found suggests that they have much in common with those reported for other neurodegenerative diseases such as Parkinson's and Alzheimer's diseases.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Journal of Neurology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/17277890/Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases","translated_internal_url":"","created_at":"2015-10-25T09:31:13.736-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36925655,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":7949052,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":37081080,"co_author_invite_id":1774868,"email":"d***4@hotmail.com","affiliation":"Universidad Nacional Autónoma de México","display_order":0,"name":"Rosalinda Díaz","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"},{"id":7949063,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":null,"co_author_invite_id":1774869,"email":"r***a@hotmail.com","display_order":4194304,"name":"Ruth González","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"},{"id":7949066,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":12137339,"co_author_invite_id":null,"email":"c***o@gmail.com","display_order":6291456,"name":"Gilberto Campos Cruz","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"},{"id":7949070,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":37075934,"co_author_invite_id":197805,"email":"d***r@servidor.unam.mx","display_order":7340032,"name":"R. Drucker-colínc","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"},{"id":7949118,"work_id":17277890,"tagging_user_id":36925655,"tagged_user_id":34771516,"co_author_invite_id":null,"email":"j***r@unam.mx","display_order":7864320,"name":"Juan Fernandez-ruiz","title":"Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases"}],"downloadable_attachments":[{"id":42274407,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42274407/thumbnails/1.jpg","file_name":"Spinocerebellar_ataxia_type_2_olfactory_20160207-4681-7x5z58.pdf","download_url":"https://www.academia.edu/attachments/42274407/download_file","bulk_download_file_name":"Spinocerebellar_ataxia_type_2_olfactory.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42274407/Spinocerebellar_ataxia_type_2_olfactory_20160207-4681-7x5z58-libre.pdf?1454839007=\u0026response-content-disposition=attachment%3B+filename%3DSpinocerebellar_ataxia_type_2_olfactory.pdf\u0026Expires=1738802364\u0026Signature=B5aYocT6J9bTo22oQgXPdPwJt6jDnB4gFEXdogXuJTk2THljss1J1PSIaWcXJBgD47pYStdrKBlfxLOrEaC8FyvDoENDrJs2P7xjV0FAS-w5mUy8TbP0p2bJVGciSbx4gdmtb~Zp-RcLjn4OwutMcLLvtymA8DWrGi2LIUShny~ZYg~HsVv7vlrG0TQQuWrROEkfJSxvTyvZQvaTZhmHwjxl0W~OHNFZQhVX~oB6u2i~1dLh4-~jTix6SdOYarUsM05jUvJr7lty5Hfv6WeuPnk1kmTdJXk1iDIkAMrGKU4XnIEtapdvW05LSI3WfD5q3hRjyrJr7-Q8yxb6BLQajA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":null,"owner":{"id":36925655,"first_name":"Luis","middle_initials":null,"last_name":"Velazquez-perez","page_name":"LuisVelazquezperez","domain_name":"independent","created_at":"2015-10-25T09:29:26.830-07:00","display_name":"Luis Velazquez-perez","url":"https://independent.academia.edu/LuisVelazquezperez"},"attachments":[{"id":42274407,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42274407/thumbnails/1.jpg","file_name":"Spinocerebellar_ataxia_type_2_olfactory_20160207-4681-7x5z58.pdf","download_url":"https://www.academia.edu/attachments/42274407/download_file","bulk_download_file_name":"Spinocerebellar_ataxia_type_2_olfactory.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42274407/Spinocerebellar_ataxia_type_2_olfactory_20160207-4681-7x5z58-libre.pdf?1454839007=\u0026response-content-disposition=attachment%3B+filename%3DSpinocerebellar_ataxia_type_2_olfactory.pdf\u0026Expires=1738802364\u0026Signature=B5aYocT6J9bTo22oQgXPdPwJt6jDnB4gFEXdogXuJTk2THljss1J1PSIaWcXJBgD47pYStdrKBlfxLOrEaC8FyvDoENDrJs2P7xjV0FAS-w5mUy8TbP0p2bJVGciSbx4gdmtb~Zp-RcLjn4OwutMcLLvtymA8DWrGi2LIUShny~ZYg~HsVv7vlrG0TQQuWrROEkfJSxvTyvZQvaTZhmHwjxl0W~OHNFZQhVX~oB6u2i~1dLh4-~jTix6SdOYarUsM05jUvJr7lty5Hfv6WeuPnk1kmTdJXk1iDIkAMrGKU4XnIEtapdvW05LSI3WfD5q3hRjyrJr7-Q8yxb6BLQajA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology"},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases"},{"id":65927,"name":"Susan Moller Okin","url":"https://www.academia.edu/Documents/in/Susan_Moller_Okin"},{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":527780,"name":"Neurodegenerative Disease","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Disease"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":6494182,"url":"https://www.researchgate.net/profile/Juan_Fernandez-Ruiz/publication/7169991_Spinocerebellar_ataxia_type_2_olfactory_impairment_shows_a_pattern_similar_to_other_major_neurodegenerative_diseases/links/0c960522f868dbcbfa000000.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355859"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355859/Normal_prism_adaptation_but_reduced_after_effect_in_basal_ganglia_disorders_using_a_throwing_task"><img alt="Research paper thumbnail of Normal prism adaptation but reduced after-effect in basal ganglia disorders using a throwing task" class="work-thumbnail" src="https://attachments.academia-assets.com/39464182/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355859/Normal_prism_adaptation_but_reduced_after_effect_in_basal_ganglia_disorders_using_a_throwing_task">Normal prism adaptation but reduced after-effect in basal ganglia disorders using a throwing task</a></div><div class="wp-workCard_item"><span>European Journal of Neuroscience</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prism adaptation is a form of visuomotor learning in which the visual and motor systems need to b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prism adaptation is a form of visuomotor learning in which the visual and motor systems need to be adjusted because a visual perturbation is produced by horizontally displacing prisms. Despite being known for over two centuries, the neuronal substrates of this phenomenon are not yet completely understood. In this article the possible role of the basal ganglia in this kind of learning was analysed through a study of Huntington's and Parkinson's disease patients. A throwing technique requiring the use of open loop feedback was used. The variables analysed were visuomotor performance, adaptation rate and magnitude, and the after-effect. The results clearly showed that both Huntington's and Parkinson's disease groups learned at the same rate as control subjects. In addition, despite having a disturbed visuomotor performance, both experimental groups showed the same adaptation magnitude as the control group. Finally, the after-effect, which is measured after removing the prisms, is reduced in both patients groups. This reduction leads to a disruption in the normal adaptation±after-effect correlation found in normal volunteers. These results suggest that basal ganglia are not involved in this type of open-looped visuomotor learning. The large number of patients studied as well as the similarity of the ®ndings between both populations support this hypothesis. By contrast, there is an impairment in the after-effect on both basal ganglia patient populations. This impairment may be the result of the deterioration of the perceptual recalibration process involved in visuomotor learning.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9406004a97ac56a1453b99d72686587b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464182,"asset_id":17355859,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464182/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355859"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355859"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355859; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355859]").text(description); $(".js-view-count[data-work-id=17355859]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355859; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355859']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9406004a97ac56a1453b99d72686587b" } } $('.js-work-strip[data-work-id=17355859]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355859,"title":"Normal prism adaptation but reduced after-effect in basal ganglia disorders using a throwing task","translated_title":"","metadata":{"grobid_abstract":"Prism adaptation is a form of visuomotor learning in which the visual and motor systems need to be adjusted because a visual perturbation is produced by horizontally displacing prisms. Despite being known for over two centuries, the neuronal substrates of this phenomenon are not yet completely understood. In this article the possible role of the basal ganglia in this kind of learning was analysed through a study of Huntington's and Parkinson's disease patients. A throwing technique requiring the use of open loop feedback was used. The variables analysed were visuomotor performance, adaptation rate and magnitude, and the after-effect. The results clearly showed that both Huntington's and Parkinson's disease groups learned at the same rate as control subjects. In addition, despite having a disturbed visuomotor performance, both experimental groups showed the same adaptation magnitude as the control group. Finally, the after-effect, which is measured after removing the prisms, is reduced in both patients groups. This reduction leads to a disruption in the normal adaptation±after-effect correlation found in normal volunteers. These results suggest that basal ganglia are not involved in this type of open-looped visuomotor learning. The large number of patients studied as well as the similarity of the ®ndings between both populations support this hypothesis. By contrast, there is an impairment in the after-effect on both basal ganglia patient populations. This impairment may be the result of the deterioration of the perceptual recalibration process involved in visuomotor learning.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"European Journal of Neuroscience","grobid_abstract_attachment_id":39464182},"translated_abstract":null,"internal_url":"https://www.academia.edu/17355859/Normal_prism_adaptation_but_reduced_after_effect_in_basal_ganglia_disorders_using_a_throwing_task","translated_internal_url":"","created_at":"2015-10-27T10:48:05.652-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37081080,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":8084735,"work_id":17355859,"tagging_user_id":37081080,"tagged_user_id":null,"co_author_invite_id":1306596,"email":"j***r@servidor.unam.mx","display_order":0,"name":"Juan Fernández-ruiz","title":"Normal prism adaptation but reduced after-effect in basal ganglia disorders using a throwing task"},{"id":8084749,"work_id":17355859,"tagging_user_id":37081080,"tagged_user_id":37075934,"co_author_invite_id":null,"email":"d***r@servidor.unam.mx","display_order":4194304,"name":"R. 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Mischner","title":"Normal prism adaptation but reduced after-effect in basal ganglia disorders using a throwing task"}],"downloadable_attachments":[{"id":39464182,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39464182/thumbnails/1.jpg","file_name":"Normal_prism_adaptation_but_reduced_afte20151027-6950-jpg701.pdf","download_url":"https://www.academia.edu/attachments/39464182/download_file","bulk_download_file_name":"Normal_prism_adaptation_but_reduced_afte.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39464182/Normal_prism_adaptation_but_reduced_afte20151027-6950-jpg701-libre.pdf?1445971769=\u0026response-content-disposition=attachment%3B+filename%3DNormal_prism_adaptation_but_reduced_afte.pdf\u0026Expires=1738802364\u0026Signature=A08iNY7GxBvBQkp4JnT05wkjDMACoaLikQPTPSZmBunUQJW~et9IaUExQXQjpahlKxqdEsgXqepentNjqklJ5wZPp9mjYFzIMc53889GCRVz9PvKbXwjdWESkCiRM2OfKdAWwTw6XNIy9nJEIgfs-nIXIroFyv-bbjJIPUmSwOEsWP9awKtnukjzb5ViTPaSRuO-JzGF6RJFGPaQxPhQl5BUcPanF~81GD~623Yr9Ab1cVwQyNkrFHfZ69wuQk1i6HwMSiv7fNZlyk5Lb0OQHxSQ8XM7bal5Tf4b~AWpWYC3t1vFAxeMCPDj9iaz-wkPsin1eA~zmeeds653C16ApA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Normal_prism_adaptation_but_reduced_after_effect_in_basal_ganglia_disorders_using_a_throwing_task","translated_slug":"","page_count":6,"language":"en","content_type":"Work","summary":"Prism adaptation is a form of visuomotor learning in which the visual and motor systems need to be adjusted because a visual perturbation is produced by horizontally displacing prisms. Despite being known for over two centuries, the neuronal substrates of this phenomenon are not yet completely understood. In this article the possible role of the basal ganglia in this kind of learning was analysed through a study of Huntington's and Parkinson's disease patients. A throwing technique requiring the use of open loop feedback was used. The variables analysed were visuomotor performance, adaptation rate and magnitude, and the after-effect. The results clearly showed that both Huntington's and Parkinson's disease groups learned at the same rate as control subjects. In addition, despite having a disturbed visuomotor performance, both experimental groups showed the same adaptation magnitude as the control group. Finally, the after-effect, which is measured after removing the prisms, is reduced in both patients groups. This reduction leads to a disruption in the normal adaptation±after-effect correlation found in normal volunteers. These results suggest that basal ganglia are not involved in this type of open-looped visuomotor learning. The large number of patients studied as well as the similarity of the ®ndings between both populations support this hypothesis. By contrast, there is an impairment in the after-effect on both basal ganglia patient populations. This impairment may be the result of the deterioration of the perceptual recalibration process involved in visuomotor learning.","owner":{"id":37081080,"first_name":"Rosalinda","middle_initials":"","last_name":"Díaz","page_name":"RosalindaDíaz","domain_name":"unam","created_at":"2015-10-27T10:41:54.909-07:00","display_name":"Rosalinda Díaz","url":"https://unam.academia.edu/RosalindaD%C3%ADaz"},"attachments":[{"id":39464182,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39464182/thumbnails/1.jpg","file_name":"Normal_prism_adaptation_but_reduced_afte20151027-6950-jpg701.pdf","download_url":"https://www.academia.edu/attachments/39464182/download_file","bulk_download_file_name":"Normal_prism_adaptation_but_reduced_afte.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39464182/Normal_prism_adaptation_but_reduced_afte20151027-6950-jpg701-libre.pdf?1445971769=\u0026response-content-disposition=attachment%3B+filename%3DNormal_prism_adaptation_but_reduced_afte.pdf\u0026Expires=1738802364\u0026Signature=A08iNY7GxBvBQkp4JnT05wkjDMACoaLikQPTPSZmBunUQJW~et9IaUExQXQjpahlKxqdEsgXqepentNjqklJ5wZPp9mjYFzIMc53889GCRVz9PvKbXwjdWESkCiRM2OfKdAWwTw6XNIy9nJEIgfs-nIXIroFyv-bbjJIPUmSwOEsWP9awKtnukjzb5ViTPaSRuO-JzGF6RJFGPaQxPhQl5BUcPanF~81GD~623Yr9Ab1cVwQyNkrFHfZ69wuQk1i6HwMSiv7fNZlyk5Lb0OQHxSQ8XM7bal5Tf4b~AWpWYC3t1vFAxeMCPDj9iaz-wkPsin1eA~zmeeds653C16ApA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European"},{"id":484219,"name":"Basal ganglia","url":"https://www.academia.edu/Documents/in/Basal_ganglia"},{"id":662721,"name":"Huntington disease","url":"https://www.academia.edu/Documents/in/Huntington_disease"},{"id":669690,"name":"Eyeglasses","url":"https://www.academia.edu/Documents/in/Eyeglasses"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="17355858"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/17355858/Sex_related_differences_in_motor_learning_and_performance"><img alt="Research paper thumbnail of Sex-related differences in motor learning and performance" class="work-thumbnail" src="https://attachments.academia-assets.com/39464183/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/17355858/Sex_related_differences_in_motor_learning_and_performance">Sex-related differences in motor learning and performance</a></div><div class="wp-workCard_item"><span>Behavioral and Brain Functions</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Gender differences have been shown across many domains, and motor skills are no exception. One of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Gender differences have been shown across many domains, and motor skills are no exception. One of the most robust findings is a significant sex difference in throwing accuracy, which reflects the advantage of men in targeting abilities. However, little is known about the basis of this difference. To try to dissect possible mechanisms involved in this difference, here we tested for gender variations in a prism adaptation throwing task. We tested 154 subjects in a visuomotor prism adaptation task that discriminates between motor performance, visuomotor adaptation and negative aftereffects. Our results corroborate men's significant better throwing accuracy, although there were no adaptation differences between genders. In contrast, women showed significant larger negative aftereffects, which could be explained by a larger contribution of spatial alignment. These results suggest that different learning mechanisms, like strategic calibration and spatial alignment, may have different contributions in men and women.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aa8e835b5a7d480933ba36738ef59a3d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39464183,"asset_id":17355858,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39464183/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17355858"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17355858"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17355858; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17355858]").text(description); $(".js-view-count[data-work-id=17355858]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17355858; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17355858']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aa8e835b5a7d480933ba36738ef59a3d" } } $('.js-work-strip[data-work-id=17355858]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17355858,"title":"Sex-related differences in motor learning and performance","translated_title":"","metadata":{"grobid_abstract":"Gender differences have been shown across many domains, and motor skills are no exception. 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It is not known, however, wheth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Olfactory de¢cits are present in many neurodegenerative diseases. It is not known, however, whether the olfactory deterioration is caused by a common neural de¢cit, or whether it is unique to each disease. We report here the e¡ect of degeneration of di¡erent brain structures on olfactory impairment in Huntington's disease as determined by voxel-based morphometric analysis. The structures with the greatest e¡ect on the olfactory de¢cit were the entorhinal cortex, the thalamus, the parahippocampal gyrus, and the caudate nucleus. Although various neuroimaging studies have shown previously that the caudate nucleus is involved in olfaction, this is the ¢rst demonstration that it is related to an olfactory dysfunction in a neurodegenerative disease. The results are discussed in relation to other neurodegenerative diseases. NeuroReport 18:73^76</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a45c591f082561fee7e2bc917dcf1414" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39430302,"asset_id":17283054,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39430302/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="17283054"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="17283054"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17283054; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17283054]").text(description); $(".js-view-count[data-work-id=17283054]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17283054; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='17283054']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a45c591f082561fee7e2bc917dcf1414" } } $('.js-work-strip[data-work-id=17283054]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":17283054,"title":"Olfaction and neurodegeneration in HD","translated_title":"","metadata":{"grobid_abstract":"Olfactory de¢cits are present in many neurodegenerative diseases. 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