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Proteomic Profiling of Medullary Thyroid Cancer Identifies CAPN1 as a Key Regulator of NF1 and RET Fueled Growth. <em class='incite-journal-name' onclick='ShowInCiteJournal(169332);'>Thyroid</em> 2025;<b>35</b>:177-187. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39868924' target='_blank'>39868924</a> DOI: <a href='https://dx.doi.org/10.1089/thy.2024.0102' target='_blank'>10.1089/thy.2024.0102</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1089/thy.2024.0102','39868924', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1089/thy.2024.0102' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169332);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/thyroid' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/28/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1089/thy.2024.0102" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Background: Medullary thyroid cancer (MTC) is a frequently metastatic tumor of the thyroid that develops from the malignant transformation of C-cells. These tumors most commonly have activating mutations within the RET or RAS proto-oncogenes. Germline mutations within RET result in C-cell hyperplasia, and cause the MTC pre-disposition disorder, multiple endocrine neoplasia, type 2A (MEN2A). Single-agent therapies for MTC, including vandetanib (VAN) and cabozantinib for all MTCs and selpercatinib (SEL) for RET-mutated MTC, lead to partial responses but are not curative. Methods: To identify new therapeutic targets for MTC, we conducted proteomic profiling of normal C-cells, MTC cells, pre-malignant MEN2A patient samples, and MTC tumors. Results: From this analysis, we identified CAPN1, a member of the CALPAIN (CAPN) family endopeptidases, as widely upregulated in MTC samples. We found that short hairpin RNA-mediated depletion of CAPN1 or inhibitors of CAPN1 significantly reduced MTC cell growth, colony formation, and xenograft tumor growth in vivo. In addition, we show that CAPN1 inhibitors synergize with VAN and SEL in vitro, maximizing apoptosis. Mechanistic experiments implicate CAPN1 in inhibiting neurofibromin, encoded by NF1, and CAPN1 inhibitors stabilize NF1 protein levels and diminish downstream RAS/RET activation of AKT and ERK. Conclusions: Our data suggest that increased CAPN1 levels support RET and RAS-fueled growth by reducing NF1 levels. We find that combinatorial therapies between CAPN1 inhibitors and VAN or SEL show maximal efficacy in MTC cells. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAPN1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAPN1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RET%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RET</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22medullary+thyroid+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">medullary thyroid cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22proteomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">proteomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22selpercatinib%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">selpercatinib</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vandetanib%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vandetanib</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Xu L</b>, Jang H, Nussinov R. Allosteric modulation of NF1 GAP: Differential distributions of catalytically competent populations in loss-of-function and gain-of-function mutants. <em class='incite-journal-name' onclick='ShowInCiteJournal(19852);'>Protein Sci</em> 2025;<b>34</b>:e70042. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39840811' target='_blank'>39840811</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751910' target='_blank'>PMC11751910</a> DOI: <a href='https://dx.doi.org/10.1002/pro.70042' target='_blank'>10.1002/pro.70042</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/pro.70042','39840811', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(2);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1002/pro.70042' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19852);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/09/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/23/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1002/pro.70042" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromin (NF1), a Ras GTPase-activating protein (GAP), catalyzes Ras-mediated GTP hydrolysis and thereby negatively regulates the Ras/MAPK pathway. NF1 mutations can cause neurofibromatosis type 1 manifesting tumors, and neurodevelopmental disorders. Exactly how the missense mutations in the GAP-related domain of NF1 (NF1GRD) allosterically impact NF1 GAP to promote these distinct pathologies is unclear. Especially tantalizing is the question of how same-domain, same-residue NF1GRD variants exhibit distinct clinical phenotypes. Guided by clinical data, we take up this dilemma. We sampled the conformational ensembles of NF1GRD in complex with GTP-bound K-Ras4B by performing molecular dynamics simulations. Our results show that mutations in NF1GRD retain the active conformation of K-Ras4B but with biased propensities of the catalytically competent populations of K-Ras4B-NF1GRD complex. In agreement with clinical depiction and experimental tagging, compared to the wild type, NF1GRD E1356A and E1356V mutants effectively act through loss-of-function and gain-of-function mechanisms, leading to neurofibromatosis and developmental disorders, respectively. Allosteric modulation of NF1GRD GAP activity through biasing the conformational ensembles in the different states is further demonstrated by the diminished GAP activity by NF1GRD isoform 2, further manifesting propensities of conformational ensembles as powerful predictors of protein function. Taken together, our work identifies a NF1GRD hotspot that could allosterically tune GAP function, suggests targeting Ras oncogenic mutations by restoring NF1 catalytic activity, and offers a molecular mechanism for NF1 phenotypes determined by their distinct conformational propensities. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GTPase%e2%80%90activating+protein%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GTPase‐activating protein</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ras%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ras</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22developmental+disorder%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">developmental disorder</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mutations%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mutations</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromin</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Allosteric+Regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Allosteric Regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Dynamics+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Dynamics Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gain+of+Function+Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gain of Function Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Loss+of+Function+Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Loss of Function Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+p21(ras)%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins p21(ras)/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+p21(ras)%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins p21(ras)/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+p21(ras)%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins p21(ras)/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2c+Missense%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation, Missense</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Conformation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Conformation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HHSN261201500003C NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HHSN261201500003I NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intramural+Research+Program+of+the+NIH%2c+National+Cancer+Institute%2c+Center+for+Cancer+Research%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research</a></li></ul> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Longakit AN</b>, Urtatiz O, Luty A, Zhang C, Hess C, Yoo A, Bourget H, Van Raamsdonk CD. Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells. <em>CANCER RESEARCH COMMUNICATIONS</em> 2025;<b>5</b>:209-225. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39804140' target='_blank'>39804140</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788999' target='_blank'>PMC11788999</a> DOI: <a href='https://dx.doi.org/10.1158/2767-9764.crc-24-0386' target='_blank'>10.1158/2767-9764.crc-24-0386</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1158/2767-9764.crc-24-0386','39804140', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1158/2767-9764.crc-24-0386' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/08/2025]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/04/2025]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1158/2767-9764.crc-24-0386" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">SIGNIFICANCE</div><div class="abstract-content">These results indicate that NF1 loss in intradermal and uveal melanomas is a potentially significant finding. They emphasize the importance of neurofibromin in cAMP signaling. They show for the first time that oncogenic GNAQ can transform Schwann cells in mice. The Plp1-creERT transgene with tamoxifen given at 5 weeks may be a particularly good strategy for modeling cutaneous neurofibroma and plexiform neurofibroma. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schwann+Cells%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schwann Cells/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schwann+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schwann Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uveal+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uveal Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uveal+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uveal Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GTP-Binding+Protein+alpha+Subunits%2c+Gq-G11%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GTP-Binding Protein alpha Subunits, Gq-G11/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GTP-Binding+Protein+alpha+Subunits%2c+Gq-G11%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GTP-Binding Protein alpha Subunits, Gq-G11/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin Neoplasms/pathology</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinogenesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinogenesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinogenesis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinogenesis/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Fay CX</b>, Zunica ERM, Awad E, Bradley W, Church C, Liu J, Liu H, Crossman DK, Mobley JA, Kirwan JP, Axelrod CL, Westin E, Kesterson RA, Wallis D. Global proteomics and affinity mass spectrometry analysis of human Schwann cells indicates that variation in and loss of neurofibromin (NF1) alters protein expression and cellular and mitochondrial metabolism. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2025;<b>15</b>:3883. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39890807' target='_blank'>39890807</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785952' target='_blank'>PMC11785952</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-84493-y' target='_blank'>10.1038/s41598-024-84493-y</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-84493-y','39890807', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1038/s41598-024-84493-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/03/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1038/s41598-024-84493-y" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In efforts to evaluate potential biomarkers and drug targets for Neurofibromatosis Type I (NF1) we utilized affinity mass spectrometry and global proteomics to investigate how variation within and loss of NF1 affect immortalized human Schwann cells. We used Strep tagged mNf1 cDNAs (both wild type (WT) and variant) to affinity purity NF1 Protein-Protein interactors (PPIs) from the Schwann cells. We were able to identify 98 PPIs and show that some of these PPIs bind differentially to variant proteins. Next, we evaluated global proteomes. We identified over 1900 proteins in immortalized human Schwann cells both with and without NF1 expression. We identified 148 proteins with differential expression levels based on genotype. Following Ingenuity Pathway analysis (IPA) we found multiple pathways were altered including decreases in "oxidative phosphorylation," increases in "mitochondrial dysfunction", and "glycolysis", as well as changes in "Myelination Signaling Pathway." When we evaluated the proteome of NF1 null cells stably transfected with tagged mNf1 cDNAs we again identified an overall trend of metabolic differences pertaining to "oxidative phosphorylation", "mitochondria dysfunction", and "glycolysis" in the variant cDNA expressing cells. We then validated differential expression of the following proteins: LAMC1, CYB5R3, and SOD2 that are observed in the altered pathways. Finally, consistent with our proteomics findings, we show that NF1 is required to maintain mitochondrial respiratory function in Schwann cells by stabilizing NADH-linked oxidative phosphorylation and electron transfer. Taken together, these data indicate that NF1 plays a significant role in mitochondrial metabolism that results in proteomic changes in Schwann cells and may serve as a future drug target. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurological+disorders%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurological disorders</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22proteome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">proteome</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schwann+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schwann Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proteomics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proteomics/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mass+Spectrometry%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mass Spectrometry/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proteome%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proteome/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Sait SF</b>, Tang KH, Angus SP, Brown R, Sun D, Xie X, Iltis C, Lien M, D. Socci N, Bale TA, Davis C, Dixon SAH, Zhang C, Wade Clapp D, Neel BG, Parada LF. Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors. <em class='incite-journal-name' onclick='ShowInCiteJournal(19666);'>Proc Natl Acad Sci U S A</em> 2025;<b>122</b>:e2407745121. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39793045' target='_blank'>39793045</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725864' target='_blank'>PMC11725864</a> DOI: <a href='https://dx.doi.org/10.1073/pnas.2407745121' target='_blank'>10.1073/pnas.2407745121</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1073/pnas.2407745121','39793045', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(5);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1073/pnas.2407745121' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19666);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/12/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1073/pnas.2407745121" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas and the primary cause of mortality in patients with neurofibromatosis type 1 (NF1). These malignancies develop within preexisting benign lesions called plexiform neurofibromas (PNs). PNs are solely driven by biallelic NF1 loss eliciting RAS pathway activation, and they respond favorably to MEK inhibitor therapy. MPNSTs harbor additional mutations and respond poorly to MEK inhibition. Our analysis of genetically engineered and orthotopic patient-derived xenograft MPNST models indicates that MEK inhibition has poor antitumor efficacy. By contrast, upstream inhibition of RAS through the protein-tyrosine phosphatase SHP2 reduced downstream signaling and suppressed NF1 MPNST growth, although resistance eventually emerged. To investigate possible mechanisms of acquired resistance, kinomic analyses of resistant tumors were performed, and data analysis identified enrichment of activated autophagy pathway protein kinases. Combining SHP2 inhibition with hydroxychloroquine (HQ) resulted in durable responses in NF1 MPNSTs in both genetic and orthotopic xenograft mouse models. Our studies could be rapidly translated into a clinical trial to evaluate SHP2 inhibition in conjunction with HQ as a unique treatment approach for NF1 MPNSTs. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MPNST%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MPNST</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SHP2+inhibition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SHP2 inhibition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hydroxychloroquine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hydroxychloroquine</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Tyrosine+Phosphatase%2c+Non-Receptor+Type+11%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Tyrosine+Phosphatase%2c+Non-Receptor+Type+11%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Tyrosine+Phosphatase%2c+Non-Receptor+Type+11%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Tyrosine Phosphatase, Non-Receptor Type 11/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a 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HHS</a></li></ul> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>García‐Díaz JDD</b>, Balsa‐Vázquez J, Rodríguez‐Villa A, Férriz E. Different de novo mutations in the NF1 gene in a family with neurofibromatosis type 1. <em class='incite-journal-name' onclick='ShowInCiteJournal(18805);'>Pediatr Dermatol</em> 2025;<b>42</b>:136-138. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39225241' target='_blank'>39225241</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781016' target='_blank'>PMC11781016</a> DOI: <a href='https://dx.doi.org/10.1111/pde.15734' target='_blank'>10.1111/pde.15734</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/pde.15734','39225241', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1111/pde.15734' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18805);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://wiley.atyponrex.com/dashboard?siteName=PDE' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1111/pde.15734" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The criteria for clinical diagnosis of neurofibromatosis type 1 (NF1) are not sensitive in young children. Recognition is easier when one of their parents has been diagnosed with this condition, and the causal mutation is known. We present a case of a girl with isolated café-au-lait spots, whose father was diagnosed with NF1. However, both were found to carry different de novo mutations in the NF1 gene. This possibility has significant implications for the diagnostic process and genetic counseling. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1+gene%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1 gene</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22de+novo+mutations%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">de novo mutations</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetic+counseling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetic counseling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetic+diagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetic diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis type 1</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cafe-au-Lait+Spots%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cafe-au-Lait Spots/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genes%2c+Neurofibromatosis+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genes, Neurofibromatosis 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pedigree%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pedigree</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Hartung TI</b>, Kluwe L, Friedrich RE, Farschtschi SC. Two Different <i>NF1</i> Pathogenic Variants in a Family With Neurofibromatosis Type 1. <em class='incite-journal-name' onclick='ShowInCiteJournal(4411);'>Cancer Genomics Proteomics</em> 2025;<b>22</b>:41-45. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39730180' target='_blank'>39730180</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696324' target='_blank'>PMC11696324</a> DOI: <a href='https://dx.doi.org/10.21873/cgp.20485' target='_blank'>10.21873/cgp.20485</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.21873/cgp.20485','39730180', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.21873/cgp.20485' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4411);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.21873/cgp.20485" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND/AIM</div><div class="abstract-content">Neurofibromatosis type 1 (NF1) is a genetic disorder with an incidence of approximately one in 3,000. More than half of the patients have new de novo pathogenic variants of the NF1 gene. In most family cases, all family members share an identical NF1-variant. The aim of the study was to investigate the very rare phenomenon of de novo variants in cases of familial neurofibromatosis type 1 and highlight its implications for genetic testing and counseling. </div><div class="abstract-label">PATIENTS AND METHODS</div><div class="abstract-content">Patients underwent clinical examination in our NF outpatient clinic and genetic testing for the NF1-gene was performed by targeted sequencing. All family members were profiled by short-tandem repeat marker analysis. Additionally, a probability calculation was performed for this extremely rare event. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In one NF1 family consisting of mother, father, and two sons, two different pathogenic variants of the NF1 gene were found. The father and one son share one NF1-variant and the other son carries a different de novo NF1-variant. Neither of these two NF1-variants was found in the unaffected mother. Short-tandem repeat analysis confirmed the paternity and revealed that the two sons inherited two different NF1-alleles from their father. The probability of two different NF1-variants occurring in one family is calculated as 1:9,000,000. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Two different NF1-variants in one family is an extremely rare phenomenon: yet its occurrence is not impossible and therefore should be considered in genetic diagnosis and counselling. For an offspring with the indication for neurofibromatosis type 1, but lacking the familial pathogenic variant, a screening of the whole NF1-gene is necessary to detect potential new pathogenic variants and for exact diagnosis. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22de+novo+pathogenic+variant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">de novo pathogenic variant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22familial+transmission%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">familial transmission</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22independent+variants%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">independent variants</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pedigree%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pedigree</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Testing</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Rosenberger LH</b>, Riedel RF, Diego EJ, Nash AL, Grilley-Olson JE, Danziger NA, Sokol ES, Ross JS, Sammons SL. Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities. <em class='incite-journal-name' onclick='ShowInCiteJournal(168995);'>Oncologist</em> 2024;<b>29</b>:1024-1031. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39191445' target='_blank'>39191445</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630793' target='_blank'>PMC11630793</a> DOI: <a href='https://dx.doi.org/10.1093/oncolo/oyae218' target='_blank'>10.1093/oncolo/oyae218</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/oncolo/oyae218','39191445', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1093/oncolo/oyae218' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168995);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1093/oncolo/oyae218" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Malignant phyllodes tumors (MPT) are rare fibroepithelial breast cancers with no known effective systemic therapy; metastatic progression portends a dismal prognosis. We sought to describe the genomic landscape of MPTs through genomic profiling and immunotherapeutic biomarker analysis. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Cases of sequenced MPT were identified from a Clinical Laboratory Improvement Amendments-certified, College of American Pathologists-accredited laboratory (Foundation Medicine). All cases underwent genomic profiling using adaptor ligation-based, next-generation sequencing assay of 324 genes. Tumor agnostic immunotherapy biomarkers, microsatellite instability, tumor mutational burden (TMB), and programmed death-ligand 1 (PD-L1) expression were evaluated. Fisher's Exact Tests and analysis of variance were used to test for differences between groups and for continuous variables as appropriate. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Of 135 MPT cases identified; 94 (69.6%) were localized/locally recurrent and 41 (30.4%) were metastatic. Median age was 54 years (range 14-86). The median TMB was 2.5 mut/Mb and 3 were TMB-high (≥10 mut/Mb). 21.4% were PD-L1+ via Dako 22C3 assay (CPS ≥1). Most commonly altered genes included TERT-promoter (69.7%), CDKN2A (45.9%), TP53 (37.8%), NF1 (35.6%), CDKN2B (33.3%), MED12 (28.9%), MTAP (27.7%), KMT2D (22.2%), PIK3CA (20.0%), PTEN (18.5%), and RB1 (18.5%). Several tumors harboring genomic alterations with US Food and Drug Administration-approved indications in other tumor types were found including NF1, PIK3CA, EGFR Exon 19/20 insertions, and BRAF V600E mutations. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">In the largest genomic evaluation of MPT to date, multiple clinically actionable mutations were found. Routine sequencing of metastatic MPT may provide additional information to guide treatment decisions and clinical trial enrollment. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5cn++++++++++TERT+promoter%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"> TERT promoter</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genomic+mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genomic mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genomic+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genomic sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22malignant+phyllodes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">malignant phyllodes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phyllodes+tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phyllodes tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22targeted+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">targeted therapy</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phyllodes+Tumor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phyllodes Tumor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phyllodes+Tumor%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phyllodes Tumor/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%2c+80+and+over%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged, 80 and over</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2c+Tumor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers, Tumor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genomics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genomics/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22High-Throughput+Nucleotide+Sequencing%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">High-Throughput Nucleotide Sequencing/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Cheng B</b>, Yang H, Huang L, Liao P, Peng F, Wang X. Nephrotic syndrome in a child with neurofibromatosis type 1: A case report and literature review. <em class='incite-journal-name' onclick='ShowInCiteJournal(17227);'>Nephrology (Carlton)</em> 2024;<b>29</b>:973-976. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39291589' target='_blank'>39291589</a> DOI: <a href='https://dx.doi.org/10.1111/nep.14393' target='_blank'>10.1111/nep.14393</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/nep.14393','39291589', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1111/nep.14393' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17227);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1111/nep.14393" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that caused by NF1 mutations. NF1 gene encodes neurofibromin (a GTPase-activating protein) and plays a regulatory role in many signalling pathway such as the Ras/MAPK pathway, which is important for regulating cell growth, proliferation and neural development. Therefore, NF1 gene mutations causes the excessive activation of signalling pathways and uncontrolled cell growth. NF1 exhibits complete genetic penetrance and clinical heterogeneity. Glomerular disease has rarely been reported in patients with NF1, especially in children. Currently, the relationship between NF1 and nephrotic syndrome is unclear. Here, we present a case of NF1 with nephrotic syndrome and further explore the association between NF1 and glomerular diseases. It also reminds clinicians that NF1 has complex and highly variable clinical manifestations and that a comprehensive workup is essential for patients. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mTOR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mTOR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nephrotic+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nephrotic syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromin+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromin 1</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biopsy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biopsy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genetic+Predisposition+to+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genetic Predisposition to Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephrotic+Syndrome%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephrotic Syndrome/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephrotic+Syndrome%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephrotic Syndrome/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nephrotic+Syndrome%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nephrotic Syndrome/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Construction+Project+of+Research+Division+of+Children%27s+Kidney+Disease+of+Wuhan+Children%27s+Hospital%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022FEYJS003 Construction Project of Research Division of Children's Kidney Disease of Wuhan Children's Hospital</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Xin H</b>, Li Y, Zhang K, Ji A, Fan M. Generation of an induced pluripotent stem cell line from a type 1 neurofibromatosis patient with NF1 mutation. <em class='incite-journal-name' onclick='ShowInCiteJournal(21543);'>Stem Cell Res</em> 2024;<b>81</b>:103568. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39332134' target='_blank'>39332134</a> DOI: <a href='https://dx.doi.org/10.1016/j.scr.2024.103568' target='_blank'>10.1016/j.scr.2024.103568</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.scr.2024.103568','39332134', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.scr.2024.103568' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21543);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/scr/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.scr.2024.103568" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">A human induced pluripotent stem cell (iPSC) line was generated from patient with type 1 neurofibromatosis (NF-1), carrying heterozygous mutation in NF1 gene. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using non-integrating delivery of KFL4, OCT4, SOX2, BCL-XL and c-MYC. The iPSC line expresses pluripotency markers, displays a normal karyotype, and is able to differentiate into three germ layers in vitro. This iPSC line represents a valuable cell model for NF1 in humans. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Induced+Pluripotent+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Induced Pluripotent Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocytes%2c+Mononuclear%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocytes, Mononuclear/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocytes%2c+Mononuclear%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocytes, Mononuclear/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Reprogramming</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>de la Guardia V</b>, Castro-Pérez E, Porcell AI, de Tena-Dávila SG, Pacheco M. Atypical cellular neurothekeoma: a case report with a novel NF1 mutation. <em class='incite-journal-name' onclick='ShowInCiteJournal(7765);'>Diagn Pathol</em> 2024;<b>19</b>:151. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39578817' target='_blank'>39578817</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583657' target='_blank'>PMC11583657</a> DOI: <a href='https://dx.doi.org/10.1186/s13000-024-01578-y' target='_blank'>10.1186/s13000-024-01578-y</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s13000-024-01578-y','39578817', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s13000-024-01578-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7765);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/24/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1186/s13000-024-01578-y" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Atypical cellular neurothekeoma is a rare benign soft-tissue tumour that usually arises in the head and neck region, shoulder girdles, and proximal extremities, predominantly in young women. This dermal neoplasm is under-reported in the literature and is not uncommonly misdiagnosed as a malignant tumour due to its worrisome histologic characteristics. Currently, the diagnosis of cellular neurothekeoma relies on a panel of non-specific immunohistochemical markers and its etiopathogenesis is unknown.Herein, we present the case of an atypical cellular neurothekeoma in the arm of a 49-year-old woman, describing its microscopic features and immunohistochemical profile. Additionally, we present a novel heterozygous predicted inactivating NF1 mutation, not previously reported, which was identified using high-throughput molecular techniques. Such finding might provide insights into the pathogenesis of neurothekeoma, potentially contributing to future refinements in diagnosis, which would enable more precise identification of this neoplasm. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atypical+cellular+neurothekeoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atypical cellular neurothekeoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Whole+exome+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Whole exome sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurothekeoma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurothekeoma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurothekeoma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurothekeoma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurothekeoma%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurothekeoma/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Soft+Tissue+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Soft Tissue Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Soft+Tissue+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Soft Tissue Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Soft+Tissue+Neoplasms%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Soft Tissue Neoplasms/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2c+Tumor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers, Tumor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2c+Tumor%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers, Tumor/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunohistochemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunohistochemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Marasco M</b>, Kumar D, Seale T, Borrego SG, Kaplun E, Aricescu I, Cole S, Qeriqi B, Qiu J, Chen X, Bahr A, Fidele D, Hofmann MH, Gerlach D, Savarese F, Merghoub T, Wolchok JD, Yao Z, de Stanchina E, Solit D, Misale S, Rosen N. Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(171780);'>Cell Rep Med</em> 2024;<b>5</b>:101818. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39488215' target='_blank'>39488215</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604403' target='_blank'>PMC11604403</a> DOI: <a href='https://dx.doi.org/10.1016/j.xcrm.2024.101818' target='_blank'>10.1016/j.xcrm.2024.101818</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.xcrm.2024.101818','39488215', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(12);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.xcrm.2024.101818' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(171780);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.xcrm.2024.101818" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromin (NF1) is a negative regulator of RAS signaling, frequently mutated in cancer. NF1-mutant melanoma is a highly malignant tumor for which targeted therapies are lacking. Here, we use biochemical and pharmacological assays on patient-derived models and isogenic cell lines to identify potential pharmacologic targets, revealing that NF1-null melanomas are dependent on RAS activation and that MEK inhibition relieves ERK-dependent negative feedback, increasing RAS signaling. MEK inhibition with avutometinib abrogates the adaptive rebound in ERK signaling, but the antitumor effects are limited. However, concurrent inhibition of MEK and SOS1 abrogates ERK activation, induces cell death, and suppresses tumor growth. In contrast to the NF1-deficient setting, concurrent SOS1 and SOS2 depletion is required to completely inhibit RAS signaling in NF1 wild-type cells. In sum, our data provide a mechanistic rationale for enhancing the therapeutic efficacy of MEK inhibitors by exploiting the lower residual SOS activity in NF1-null tumor cells. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MEK+inhibition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MEK inhibition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SOS1+inhibition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SOS1 inhibition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22combination+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">combination therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22melanoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">melanoma</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SOS1+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SOS1 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SOS1+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SOS1 Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Kinase+Inhibitors%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Kinase Inhibitors/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitogen-Activated+Protein+Kinase+Kinases%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitogen-Activated+Protein+Kinase+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitogen-Activated Protein Kinase Kinases/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 CA008748 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Miranda-Román MA</b>, Lee CJ, Fishinevich E, Ran L, Patel AJ, Yan J, Khudoynazarova MN, Warda S, Pachai MR, Chen Y, Chi P. MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor. <em class='incite-journal-name' onclick='ShowInCiteJournal(169089);'>Clin Cancer Res</em> 2024;<b>30</b>:5154-5165. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39269317' target='_blank'>39269317</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565172' target='_blank'>PMC11565172</a> DOI: <a href='https://dx.doi.org/10.1158/1078-0432.ccr-24-1750' target='_blank'>10.1158/1078-0432.ccr-24-1750</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1158/1078-0432.ccr-24-1750','39269317', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(13);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1158/1078-0432.ccr-24-1750' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169089);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1158/1078-0432.ccr-24-1750" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive subtype of soft-tissue sarcoma with a high propensity to metastasize and extremely limited treatment options. Loss of the RAS-GAP NF1 leads to sustained RAF/MEK/ERK signaling in MPNST. However, single-agent MEK inhibitors (MEKi) have failed to elicit a sustained inhibition of the MAPK signaling pathway in MPNST. </div><div class="abstract-label">EXPERIMENTAL DESIGN</div><div class="abstract-content">We used pharmacological, biochemical, and genetic perturbations of the receptor tyrosine kinase and MAPK signaling pathway regulators to investigate the mechanisms of MEKi resistance and evaluated combination therapeutic strategies in various preclinical MPNST models in vitro and in vivo. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Here, we report that MEKi treatment resistance in MPNST involves two adaptive pathways: direct transcriptional upregulation of the receptor tyrosine kinase PDGFRβ and MEKi-induced increase in RAF dimer formation and activation of downstream signaling. Although the pharmacologic combination of a MEKi with a PDGFRβ-specific inhibitor was more effective than treatment with the MEKi alone, the combination of the MEKi and RAF dimer inhibitors led to a robust inhibition of MAPK pathway signaling. This combination treatment was effective in vitro and in vivo, as demonstrated by the significant increase in drug synergism and its high effectiveness in decreasing MPNST viability. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our findings suggest that the combination of MEKis and PDGFR and/or RAF dimer inhibitors can overcome MEKi resistance and may serve as a novel targeted therapeutic strategy for patients with NF1-deficient MPNST, which in turn could impact future clinical investigations for this patient population. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+Platelet-Derived+Growth+Factor+beta%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, Platelet-Derived Growth Factor 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target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Bergoug M</b>, Mosrin C, Serrano A, Godin F, Doudeau M, Dundović I, Goffinont S, Normand T, Suskiewicz MJ, Vallée B, Bénédetti H. An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. <em class='incite-journal-name' onclick='ShowInCiteJournal(14504);'>J Mol Biol</em> 2024;<b>436</b>:168768. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39216515' target='_blank'>39216515</a> DOI: <a href='https://dx.doi.org/10.1016/j.jmb.2024.168768' target='_blank'>10.1016/j.jmb.2024.168768</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jmb.2024.168768','39216515', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jmb.2024.168768' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14504);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.jmb.2024.168768" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromin (Nf1) is a giant multidomain protein encoded by the tumour-suppressor gene NF1. NF1 is mutated in a common genetic disease, neurofibromatosis type I (NF1), and in various cancers. The protein has a Ras-GAP (GTPase activating protein) activity but is also connected to diverse signalling pathways through its SecPH domain, which interacts with lipids and different protein partners. We previously showed that Nf1 partially colocalized with the ProMyelocytic Leukemia (PML) protein in PML nuclear bodies, hotspots of SUMOylation, thereby suggesting the potential SUMOylation of Nf1. Here, we demonstrate that the full-length isoform 2 and a SecPH fragment of Nf1 are substrates of the SUMO pathway and identify a well-defined SUMOylation profile of SecPH with two main modified lysines. One of these sites, K1731, is highly conserved and surface-exposed. Despite the presence of an inverted SUMO consensus motif surrounding K1731, and a potential SUMO-interacting motif (SIM) within SecPH, we show that neither of these elements is necessary for K1731 SUMOylation, which is also independent of Ubc9 SUMOylation on K14. A 3D model of an interaction between SecPH and Ubc9 centred on K1731, combined with site-directed mutagenesis, identifies specific structural elements of SecPH required for K1731 SUMOylation, some of which are affected in reported NF1 pathogenic variants. This work provides a new example of SUMOylation dependent on the tertiary rather than primary protein structure surrounding the modified site, expanding our knowledge of mechanisms governing SUMOylation site selection. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SCM-+and+SIM-independent+SUMOylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SCM- and SIM-independent SUMOylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ubc9+fusion-directed+SUMOylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ubc9 fusion-directed SUMOylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mechanism+of+SUMOylation+site+selection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mechanism of SUMOylation site selection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22model+of+Nf1-SecPH%2fUbc9+interaction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">model of Nf1-SecPH/Ubc9 interaction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromin+(Nf1)+and+Nf1-SecPH+domain+SUMOylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromin (Nf1) and Nf1-SecPH domain SUMOylation</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sumoylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sumoylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Domains%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Domains</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ubiquitin-Conjugating+Enzymes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ubiquitin-Conjugating Enzymes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ubiquitin-Conjugating+Enzymes%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ubiquitin-Conjugating Enzymes/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ubiquitin-Conjugating+Enzymes%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ubiquitin-Conjugating Enzymes/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amino+Acid+Sequence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amino Acid Sequence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Isoforms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Isoforms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Isoforms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Isoforms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Isoforms%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Isoforms/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Lin X</b>, Chang X, Zhang Y, Gao Z, Chi X. Automatic construction of Petri net models for computational simulations of molecular interaction network. <em class='incite-journal-name' onclick='ShowInCiteJournal(18172);'>NPJ Syst Biol Appl</em> 2024;<b>10</b>:131. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39521772' target='_blank'>39521772</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550427' target='_blank'>PMC11550427</a> DOI: <a href='https://dx.doi.org/10.1038/s41540-024-00464-z' target='_blank'>10.1038/s41540-024-00464-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41540-024-00464-z','39521772', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41540-024-00464-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/fac24502e17127f72c3caf0fc2a5a017/41540_2024_Article_464.PMC11550427.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41540-024-00464-z');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18172);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1038/s41540-024-00464-z" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Petri nets are commonly applied in modeling biological systems. However, construction of a Petri net model for complex biological systems is often time consuming, and requires expertise in the research area, limiting their application. To address this challenge, we developed GINtoSPN, an R package that automates the conversion of multi-omics molecular interaction network extracted from the Global Integrative Network (GIN) into Petri nets in GraphML format. These GraphML files can be directly used for Signaling Petri Net (SPN) simulation. To demonstrate the utility of this tool, we built a Petri net model for neurofibromatosis type I. Simulation of NF1 gene knockout, compared to normal skin fibroblast cells, revealed persistent accumulation of Ras-GTPs as expected. Additionally, we identified several other genes substantially affected by the loss of NF1's function, exhibiting individual-specific variability. These results highlight the effectiveness of GINtoSPN in streamlining the modeling and simulation of complex biological systems. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22computer+modelling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">computer modelling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22numerical+simulations%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">numerical simulations</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computer+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computer Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Models%2c+Biological%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Models, Biological</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+Biology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational Biology/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Software%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Software</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Systems+Biology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Systems Biology/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Jo KH</b>, Lee J, Yoo J, Kim HS, Kim ES, Han JH, Jang YS, Yun JS, Son JW, Yoo SJ, Lee SH, Lim DJ, Kwon HS, Lee S, Moon S, Kim M. Germline Mutations and Phenotypic Associations in Korean Patients With Pheochromocytoma and Paraganglioma: A Multicenter Study and Literature Review. <em class='incite-journal-name' onclick='ShowInCiteJournal(2136);'>Ann Lab Med</em> 2024;<b>44</b>:591-597. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39069753' target='_blank'>39069753</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375186' target='_blank'>PMC11375186</a> DOI: <a href='https://dx.doi.org/10.3343/alm.2023.0376' target='_blank'>10.3343/alm.2023.0376</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3343/alm.2023.0376','39069753', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(16);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3343/alm.2023.0376' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(2136);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/30/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.3343/alm.2023.0376" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Genetic testing is recommended for all patients with pheochromocytomas and paragangliomas (PPGL) to establish genotype-phenotype associations. We investigated germline mutations in 59 patients with PPGL at six Korean university hospitals using next-generation sequencing (NGS) targeting 38 PPGL-associated genes, including those recommended by the Korean PPGL Task Force. Germline mutations were identified in 13 patients (22%), and affected four genes: RET, NF1, VHL, and SDHD. Germline mutations were significantly associated with a family history of PPGL, smaller tumor size, and the presence of other types of tumors. Using 95 Korean PPGL cases with germline mutations identified through a literature review and 13 cases from our cohort, we characterized genotype-phenotype correlations. Mutation hotspots were identified in specific codons of RET (codons 631 and 634), VHL (157 and 167), and SDHB (131 and 253). NF1 mutations varied, indicating the absence of common hotspots. These findings highlight the efficacy of the recommended NGS panel for Korean patients with PPGL and the importance of genetic testing in establishing clinical management and personalized therapeutic strategies. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Germline%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Germline</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Korean%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Korean</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Paraganglioma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Paraganglioma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pheochromocytoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pheochromocytoma</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Von+Hippel-Lindau+Tumor+Suppressor+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Von Hippel-Lindau Tumor Suppressor Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22East+Asian+People%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">East Asian People</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministry+of+Science+and+ICT%2c+South+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ministry of Science and ICT, South Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Catholic+Medical+Center+Research+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Catholic Medical Center Research Foundation</a></li></ul> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Rekha A</b>, Sanoop AVM, Das S, Chapla A, Srinageshwari B, Barney A, Arunachalam G, Mohan S, Danda S. Clinical and Molecular Profile of Neurofibromatosis Type 1 Patients Using Revised Diagnostic Criteria - A Retrospective Cohort Study. <em class='incite-journal-name' onclick='ShowInCiteJournal(17719);'>Neurol India</em> 2024;<b>72</b>:1174-1178. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39690988' target='_blank'>39690988</a> DOI: <a href='https://dx.doi.org/10.4103/ni.ni_744_22' target='_blank'>10.4103/ni.ni_744_22</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.4103/ni.ni_744_22','39690988', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.4103/ni.ni_744_22' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17719);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/03/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.4103/ni.ni_744_22" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">To catalog and correlate the clinical features and mutational spectrum of neurofibromatosis type 1 (NF1) patients attending a tertiary care center in India. </div><div class="abstract-label">METHODS</div><div class="abstract-content">NF1 patients with confirmed molecular diagnosis from 2014 to 2021 were included in the study. The molecular tests used for the diagnosis were exome sequencing, targeted gene sequencing, and Multiple Ligation Probe Assay. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Forty-two clinically diagnosed NF1 patients who had confirmed molecular diagnosis, which is now part of the revised diagnostic criteria, were included in the analysis. Nonsense variants were the most frequently observed (35.71%), followed by frameshift (23.8%), splice site (14.29%), deletion (11.9%), missense (9.5%), and in-frame deletions (4.76%) in our case series. Three variants (c. 5269-1G > C, c. 1541_1542del AG, and c. 6853_6854insA) were identified in more than one patient, suggesting that the variants are widely distributed in the gene and lack any mutational hotspot. This study supports the previous findings that patients with the variant c. 2970_2972delAAT do not develop neurofibromas; however, it was not necessary for those with whole gene deletion to have dysmorphic features as reported by other studies. The study could not establish any correlation between the type of variants and specific clinical features. Around 28% of mutations could be identified by screening exons 14, 28, 37, 46 and intron 37 in this population. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">This study will contribute to a better understanding of the phenotypic variability of neurofibromatosis patients. The variable expressivity seen in NF1 suggests that modifying genes may be involved in the development of particular clinical features in addition to NF1 mutations. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22India%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">India</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cohort+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cohort Studies</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Chang M</b>, Sherief M, Ioannou M, Chinnasamy V, Chen L, Frost M, Mattson-Hoss M, Sarnoff H, Kamson DO, Holdhoff M, Mukherjee D, Bettegowda C, Rincon-Torroella J, Croog V, Huang P, Rodriguez FJ, Lucas CHG, Schreck KC. NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes. <em class='incite-journal-name' onclick='ShowInCiteJournal(848);'>Acta Neuropathol Commun</em> 2024;<b>12</b>:172. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39472976' target='_blank'>39472976</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520828' target='_blank'>PMC11520828</a> DOI: <a href='https://dx.doi.org/10.1186/s40478-024-01875-z' target='_blank'>10.1186/s40478-024-01875-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s40478-024-01875-z','39472976', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(18);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s40478-024-01875-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1186/s40478-024-01875-z');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(848);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/02/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1186/s40478-024-01875-z" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">NF1 inactivation is associated with sensitivity to MEK inhibitor targeted therapy in low-grade and some high-grade gliomas. NF1 loss may also be a harbinger of exploitable vulnerabilities in IDH-wildtype glioblastoma (GBM). Accurate and consistent detection of NF1 loss, however, is fraught given the large gene size, challenges with complete coverage and variant calling upon sequencing, and mechanisms of mRNA and protein regulation that result in early degradation in the absence of genomic alterations. Here, we seek to perform a composite analysis for NF1 loss accounting for genomic alterations and protein expression via immunohistochemistry. We also characterize the landscape of NF1 alterations in GBM. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We assembled a single-institution, retrospective cohort of 542 IDH-wildtype GBM with somatic next generation sequencing to investigate the frequency and nature of detected NF1 alterations. We selected 69 GBMs from which to build a tissue microarray (TMA) of 44 NF1-wildtype and 25 NF1-mutant cases. We performed NF1 immunohistochemistry using two different NF1 antibodies (NFC, Sigma-Aldrich; and iNF-07E, iNFixion Bioscience) and correlated results with clinical, genomic, and other immunohistochemical features. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In our retrospective cohort, we identified 88 IDH-wildtype GBM with NF1 alterations (16%). NF1 alterations were mutually exclusive with EGFR and MDM2 alterations (p-adj < 0.001, 0.05, respectively), but co-occurred with PIK3R1 alterations (Log2(OR) = - 1.6, p-adj = 0.03). Of the 63 scorable sporadic GBMs in the TMA, 14 harbored NF1 inactivating alterations and of those, 12 (86%) demonstrated minimal NF1 immunoreactivity by NFC antibody, compared to 8 (57%) by iNF-07E antibody. Among the 42 scorable NF1-wildtype GBM in the TMA, NF1 immunostaining was minimal in 18 (43%) by NFC antibody compared to 4 (10%) by iNF-07E antibody, potentially reflecting false positives or differential protein regulation. Minimal immunoreactivity by NFC antibody was associated with decreased median overall survival (8.5 vs. 16.4 months, p = 0.011). Cox proportional hazards model correcting for prognostic variables in this subset revealed HR 3.23 (95% CI 1.29-8.06, p = 0.01) associated with decreased NF1 expression by IHC. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">NF1 immunostaining may serve as a sensitive surrogate marker of NF1 genomic inactivation and a valuable extension to next-generation sequencing for defining NF1 status. Minimal NF1 immunoreactivity is a poor prognostic marker, even in IDH-wildtype glioblastoma without apparent NF1 genomic alterations, but the underlying molecular mechanism requires further investigation. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22High-grade+glioma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">High-grade glioma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%2fmortality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma/mortality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isocitrate+Dehydrogenase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isocitrate Dehydrogenase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fmortality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/mortality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Profiling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Profiling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cohort+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cohort Studies</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DhartSpore%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CEP DhartSpore</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 CA006973 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Cancer+Institute%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Cancer Institute</a></li></ul> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>刘丕</b>. [Progress and prospects in diagnosis and treatment of neurofibromatosis type 1]. <em>ZHONGGUO XIU FU CHONG JIAN WAI KE ZA ZHI = ZHONGGUO XIUFU CHONGJIAN WAIKE ZAZHI = CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY</em> 2024;<b>38</b>:1166-1170. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39433488' target='_blank'>39433488</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522528' target='_blank'>PMC11522528</a> DOI: <a href='https://dx.doi.org/10.7507/1002-1892.202407005' target='_blank'>10.7507/1002-1892.202407005</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7507/1002-1892.202407005','39433488', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.7507/1002-1892.202407005" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease caused by mutations in the NF1 gene. The disease is characterized by neurofibromatosis, which simultaneously affects multiple systems such as nerves, skin, and bone, and has complex clinical manifestations. Since the National Institutes of Health (NIH) established diagnostic criteria in 1988, the diagnosis and treatment of NF1 have progressed significantly. However, due to the complexity of the disease and the lack of effective treatments, the diagnosis and treatment of NF1 still face many challenges. Strengthening multidisciplinary collaboration, improving and popularizing disease diagnosis and treatment strategies, and developing more effective drugs and treatment methods are the keys to further improve the treatment level of NF1 diseases. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22clinical+research%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">clinical research</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22multidisciplinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">multidisciplinary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">treatment</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>李青</b>, 王智, 魏澄. [Several suggestions for improving diagnosis and management of patients with neurofibromatosis type 1]. <em>ZHONGGUO XIU FU CHONG JIAN WAI KE ZA ZHI = ZHONGGUO XIUFU CHONGJIAN WAIKE ZAZHI = CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY</em> 2024;<b>38</b>:1157-1160. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39433486' target='_blank'>39433486</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522537' target='_blank'>PMC11522537</a> DOI: <a href='https://dx.doi.org/10.7507/1002-1892.202406062' target='_blank'>10.7507/1002-1892.202406062</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7507/1002-1892.202406062','39433486', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.7507/1002-1892.202406062" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease caused by the mutations in the NF1 gene, with an incidence of approximately 1/3 000. Affecting multiple organs and systems throughout the body, NF1 caused a wide variety of clinical symptoms. A comprehensive multidisciplinary diagnostic and treatment model is needed to meet the diverse needs of NF1 patients and improve their quality of life. In recent years, the emergence of targeted therapies has further benefited NF1 patients, and the number of clinical consultations has increased dramatically. However, due to the rarity of the disease itself and insufficient attention previously, the standardized, systematic, and precise diagnosis and treatment model of NF1 still needs to be further improved. In this paper, we reviewed the current status of comprehensive diagnosis and treatment of NF1 in China, combine with our long-term experiences in diagnosis and treatment of this disease. Meanwhile, we propose future directions and several suggestions for the comprehensive diagnosis and treatment model for Chinese NF1 patients. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+type+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis type 1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22artificial+intelligence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">artificial intelligence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22comprehensive+treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">comprehensive treatment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22precision+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">precision medicine</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Quality+of+Life%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Quality of Life</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Liang Y</b>, Li J, Li T, Li M, Liao H, Liu Y, Yao Y, Yang L, Lei X. Colorectal cancer cells with high metastatic potential drive metastasis by transmitting exosomal miR-20a-3p through modulating NF1/MAPK pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(4630);'>Carcinogenesis</em> 2024;<b>45</b>:773-785. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38829328' target='_blank'>38829328</a> DOI: <a href='https://dx.doi.org/10.1093/carcin/bgae036' target='_blank'>10.1093/carcin/bgae036</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/carcin/bgae036','38829328', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/carcin/bgae036' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4630);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1093/carcin/bgae036" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cancer cells exhibit heterogeneous metastatic potential, and high metastatic (HM) subclones can enhance the metastatic potential of low metastatic subclones by transmitting some factors. Exosomal miRNAs play a pivotal role in the crosstalk of heterogeneous metastatic subclones. This study discovered that miR-20a-3p was upregulated in colorectal adenocarcinoma (CRA), correlated with metastasis, and potentially served as a prognostic indicator for CRA. miR-20a-3p could promote the proliferation, migration, and invasion of CRA cells. Interestingly, HM CRA cells could promote malignant phenotypes of low metastatic CRA cells by transmitting exosomal miR-20a-3p. Mechanically, miR-20a-3p could inhibit neurofibromin 1(NF1), thereby activate the rat sarcoma viral oncogene (RAS)-mediated mitogen-activated protein kinases (MAPK) signaling pathway to drive the metastasis of CRA. In summary, our study provided evidence that colorectal cancer cells with HM potential drive metastasis by transmitting exosomal miR-20a-3p through modulating the NF1/MAPK pathway. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adenocarcinoma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adenocarcinoma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adenocarcinoma%2fsecondary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adenocarcinoma/secondary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prognosis</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82160561 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jiangxi+Province+Graduate+Innovation+Special+Fund+Project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">YC2022-B058 Jiangxi Province Graduate Innovation Special Fund Project</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interdisciplinary+innovation+fund+of+Nanchang+University%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">9167-28220007-YB2108 Interdisciplinary innovation fund of Nanchang University</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Chen J</b>, Li Z, Wu Y, Li X, Chen Z, Chen P, Ding Y, Wu C, Hu L. Identification of Pathogenic Missense Mutations of NF1 Using Computational Approaches. <em class='incite-journal-name' onclick='ShowInCiteJournal(169388);'>J Mol Neurosci</em> 2024;<b>74</b>:94. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39373898' target='_blank'>39373898</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458684' target='_blank'>PMC11458684</a> DOI: <a href='https://dx.doi.org/10.1007/s12031-024-02271-x' target='_blank'>10.1007/s12031-024-02271-x</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12031-024-02271-x','39373898', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(22);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s12031-024-02271-x' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169388);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/08/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1007/s12031-024-02271-x" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromatosis type 1 (NF1) is a prevalent autosomal dominant disorder caused by mutations in the NF1 gene, leading to multisystem disorders. Given the critical role of cysteine residues in protein stability and function, we aimed to identify key NF1 mutations affecting cysteine residues that significantly contribute to neurofibromatosis pathology. To identify the most critical mutations in the NF1 gene that contribute to the pathology of neurofibromatosis, we employed a sophisticated computational pipeline specifically designed to detect significant mutations affecting the NF1 gene. Our approach involved an exhaustive search of databases such as the Human Gene Mutation Database (HGMD), UniProt, and ClinVar for information on missense mutations associated with NF1. Our search yielded a total of 204 unique cysteine missense mutations. We then employed in silico prediction tools, including PredictSNP, iStable, and Align GVGD, to assess the impact of these mutations. Among the mutations, C379R, R1000C, and C1016Y stood out due to their deleterious effects on the biophysical properties of the neurofibromin protein, significantly destabilizing its structure. These mutations were subjected to further phenotyping analysis using SNPeffect 4.0, which predicted disturbances in the protein's chaperone binding sites and overall structural stability. Furthermore, to directly visualize the impact of these mutations on protein structure, we utilized AlphaFold3 to simulate both the wild-type and mutant NF1 structures, revealing the significant effects of the R1000C mutation on the protein's conformation. In conclusion, the identification of these mutations can play a pivotal role in advancing the field of precision medicine and aid in the development of effective drugs for associated diseases. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cysteine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cysteine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Missense%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Missense</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+conformation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular conformation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%2c+Missense%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation, Missense</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Stability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Stability</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Zhejiang+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LQ22C070004 Natural Science Foundation of Zhejiang Province</a></li></ul> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Wu C</b>, Shazeeb MS, Mangkalaphiban K, Han G, Peker A, Rentiya ZS, Gounis MJ, Jacobson A. Investigating therapeutic nonsense suppression in a neurofibromatosis mouse model. <em class='incite-journal-name' onclick='ShowInCiteJournal(9062);'>Exp Neurol</em> 2024;<b>380</b>:114914. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39106942' target='_blank'>39106942</a> DOI: <a href='https://dx.doi.org/10.1016/j.expneurol.2024.114914' target='_blank'>10.1016/j.expneurol.2024.114914</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.expneurol.2024.114914','39106942', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.expneurol.2024.114914' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9062);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.expneurol.2024.114914" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Neurofibromatosis type 1 (NF1) is a human genetic disorder caused by variants in the NF1 gene. Plexiform neurofibromas, one of many NF1 manifestations, are benign peripheral nerve sheath tumors occurring in up to 50% of NF1 patients. A substantial fraction of NF1 pathogenetic variants are nonsense mutations, which result in the synthesis of truncated non-functional NF1 protein (neurofibromin). To date, no therapeutics have restored neurofibromin expression or addressed the consequences of this protein's absence in NF1 nonsense mutation patients, but nonsense suppression is a potential approach to the problem. Ataluren is a small molecule drug that has been shown to stimulate functional nonsense codon readthrough in several models of nonsense mutation diseases, as well as in Duchenne muscular dystrophy patients. To test ataluren's potential applicability in nonsense mutation NF1 patients, we evaluated its therapeutic effects using three treatment regimens in a previously established NF1 patient-derived (c.2041C > T; p.Arg681X) nonsense mutation mouse model. Collectively, our experiments indicate that: i) ataluren appeared to slow the growth of neurofibromas and alleviate some paralysis phenotypes, ii) female Nf1-nonsense mutation mice manifested more severe paralysis and neurofibroma phenotypes than male mice, iii) ataluren doses with apparent effectiveness were lower in female mice than in male mice, and iv) age factors also influenced ataluren's effectiveness. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ataluren%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ataluren</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Patient-derived+Nf1+mouse+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Patient-derived Nf1 mouse model</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plexiform+neurofibromas%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plexiform neurofibromas</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+factors+in+NF1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex factors in NF1</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Codon%2c+Nonsense%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Codon, Nonsense/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromatosis+1%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromatosis 1/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxadiazoles%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxadiazoles/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxadiazoles%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxadiazoles/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Transgenic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Transgenic</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Badodi S</b>, Marino S. Epigenetic reprogramming enables NF1A/B oncogenic role in SHH medulloblastoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(7875);'>Dev Cell</em> 2024;<b>59</b>:2275-2276. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39255772' target='_blank'>39255772</a> DOI: <a href='https://dx.doi.org/10.1016/j.devcel.2024.07.002' target='_blank'>10.1016/j.devcel.2024.07.002</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.devcel.2024.07.002','39255772', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.devcel.2024.07.002' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7875);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1016/j.devcel.2024.07.002" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In this issue of Developmental Cell, Shiraishi et al. investigate the epigenetic changes occurring during the formation of SHH medulloblastoma and show that an epigenomic shift renders Nuclear Factor I family of transcription factors oncogenic. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Medulloblastoma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Medulloblastoma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Medulloblastoma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Medulloblastoma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Medulloblastoma%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Medulloblastoma/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epigenesis%2c+Genetic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epigenesis, Genetic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hedgehog+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hedgehog Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hedgehog+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hedgehog Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NFI+Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NFI Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NFI+Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NFI Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebellar+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebellar Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebellar+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebellar Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerebellar+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerebellar Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurofibromin+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurofibromin 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Ioannou M</b>, Lalwani K, Ayanlaja AA, Chinnasamy V, Pratilas CA, Schreck KC. MEK Inhibition Enhances the Antitumor Effect of Radiotherapy in NF1-Deficient Glioblastoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(17404);'>Mol Cancer Ther</em> 2024;<b>23</b>:1261-1272. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38714355' target='_blank'>38714355</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374499' target='_blank'>PMC11374499</a> DOI: <a href='https://dx.doi.org/10.1158/1535-7163.mct-23-0510' target='_blank'>10.1158/1535-7163.mct-23-0510</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1158/1535-7163.mct-23-0510','38714355', 'Neurofibromin 1/genetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1158/1535-7163.mct-23-0510' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17404);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/06/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1158/1535-7163.mct-23-0510" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Individuals with neurofibromatosis type 1, an autosomal dominant neurogenetic and tumor predisposition syndrome, are susceptible to developing low-grade glioma and less commonly high-grade glioma. These gliomas exhibit loss of the neurofibromin gene [neurofibromin type 1 (NF1)], and 10% to 15% of sporadic high-grade gliomas have somatic NF1 alterations. Loss of NF1 leads to hyperactive RAS signaling, creating opportunity given the established efficacy of MEK inhibitors in plexiform neurofibromas and some individuals with low-grade glioma. We observed that NF1-deficient glioblastoma neurospheres were sensitive to the combination of an MEK inhibitor (mirdametinib) with irradiation, as evidenced by synergistic inhibition of cell growth, colony formation, and increased cell death. In contrast, NF1-intact neurospheres were not sensitive to the combination, despite complete ERK pathway inhibition. No neurosphere lines exhibited enhanced sensitivity to temozolomide combined with mirdametinib. Mirdametinib decreased transcription of homologous recombination genes and RAD51 foci, associated with DNA damage repair, in sensitive models. Heterotopic xenograft models displayed synergistic growth inhibition to mirdametinib combined with irradiation in NF1-deficient glioma xenografts but not in those with intact NF1. In sensitive models, benefits were observed at least 3 weeks beyond the completion of treatment, including sustained phosphor-ERK inhibition on immunoblot and decreased Ki-67 expression. These observations demonstrate synergistic activity between mirdametinib and irradiation in NF1-deficient glioma models and may have clinical implications for patients with gliomas that harbor germline or somatic NF1 alterations. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glioblastoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glioblastoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%3citalic+toggle%3d%5c%22yes%5c%22%3enf1%3c%2fitalic%3e%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank"><italic toggle="yes">nf1</italic></a></li><li><a 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class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Neurofibromin 1/genetics (460 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="460" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Neurofibromin 1/genetics (460 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="460" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>