Neuroscience Research

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<div><p>Neuroscience research aims to understand the anatomy and function of the brain and central nervous system.</p></div> </div> <div class="field_block:paragraph:h1_2_2_text_to_media_multi_cta:field_call_to_action_global"> <a href="/research-areas/neuroscience#targets" class="btn btn-primary btn-cta mr-3 mb-3" type="link"> Search Products for Neuroscience Research </a> </div> <div class="field_block:paragraph:h1_2_2_text_to_media_multi_cta:field_multi_cta_links"> <div class="mt-3"> <a href="/resources" class="text-white" type="link"> <u class="text-white">Neuroscience Research Resources</u> </a> <span class="text-light"> | </span> <a href="/resources/signal-transduction-pathways" class="text-white" type="link"> <u class="text-white">Neuroscience Signaling Pathways </u> </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </header> </div> <div id="main" class="container-fluid container-wide"> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/research-areas">Research Areas</a> </li> <li> Neuroscience Research </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Neuroscience Research Products and Resources</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Neuroscience research requires a multidisciplinary approach, integrating concepts and experimental approaches from physiology, biochemistry, cellular and molecular biology, computational biology, and behavioral biology to elucidate the intricate cellular networks controlling behaviors.  </p><h2>Contents</h2><ul><li><a href="#disease-types">Neuroscience Disease Types</a></li><li><a href="#research-areas">Neuroscience Related Research Areas</a></li><li><a href="#targets">Neuroscience Research Targets</a></li><li><a href="#products">Products and Services </a></li><li><a href="#resources">Neuroscience Resources & Tools</a></li><li><a href="#background">Background </a></li></ul></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/images/research/neuro-visualize-ihc-beta-iii-tubulin-mab1195.jpg" alt="Tools for Specific and Reliable Immunocytochemistry (ICC) and immunohistochemistry (IHC) Results" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="disease-types"></a>Neuroscience Disease Types </h2><p>Browse research products by Neuroscience Disease Type:</p><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td class="w-25"><a href="/research-areas/neuroscience/neurodegeneration#Alzheimer&apos;s">Alzheimer's Disease</a></td><td class="w-25"><a href="/research-areas/neuroscience/neurodegeneration#ALS">Amyotrophic Lateral Sclerosis</a></td><td class="w-25"><a href="/research-areas/neuroscience/neurodegeneration#Parkinson&apos;s">Depression</a></td><td><a href="/search?search_type=products&keywords=epilepsy">Epilepsy</a></td></tr><tr><td><a href="/research-areas/neuroscience/neurodegeneration#Huntington&apos;s">Huntington's Disease</a></td><td><a href="/search?search_type=products&keywords=Multiple+Sclerosis">Multiple Sclerosis</a></td><td><a href="/search?search_type=products&keywords=pain">Pain </a></td><td><a href="/search?search_type=products&keywords=parkinson+disease">Parkinson's Disease</a></td></tr><tr><td><a href="/search?search_type=products&keywords=schizophrenia">Schizophrenia </a></td><td> </td><td> </td><td> </td></tr></tbody></table></figure><p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="research-areas"></a>Neuroscience Research Areas</h2><p>Browse research products by Neuroscience Related Research Area:</p><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td><a href="/research-areas/autophagy">Autophagy</a></td><td><a href="/research-areas/neuroscience-solutions#Biomarker%20Quantitation">Biomarker Detection</a></td><td><a href="/search?search_type=products&keywords=circadian">Circadian Rhythm</a></td><td><a href="/research-areas/neuroscience-solutions#Diagnostics">Diagnostics</a></td></tr><tr><td class="w-25"><a href="/applications/electrophysiology">Electrophysiology</a></td><td><a href="/research-areas/epigenetics">Epigenetics</a></td><td><a href="/research-areas/cancer/exosomes-in-neurodegenerative-disease">Exosomes in Neurodegeneration</a></td><td><a href="/research-areas/gpcrs">GPCRs</a></td></tr><tr><td><a href="/research-areas/neuroscience/gut-brain-axis">Gut-brain-axis</a></td><td><a href="/research-areas/neuroscience-solutions#Modulate%20Neural">Modulate Neural Activity</a></td><td><a href="/research-areas/stem-cells/neural-stem-cells">Neural Stem Cells</a> </td><td><a href="/research-areas/neuroscience-solutions#Neural%20Cell%20Culture">Neural Cell Culture</a></td></tr><tr><td><a href="/research-areas/neuroscience-solutions#Neural%20Cell%20Imaging">Neural Cell Imaging</a></td><td><a href="/research-areas/neuroscience/neurodegeneration">Neurodegeneration</a></td><td><a href="/research-areas/neuroscience/neuroendocrinology">Neuroendocrinology</a></td><td><a href="/research-areas/neuroscience-solutions#Spatial%20Mapping">Spatial Mapping and Phenotyping</a></td></tr></tbody></table></figure><p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="targets"></a>Neuroscience Targets</h2><p>Browse research products by Neuroscience Target:</p><figure class="responsive-figure-table"><table class="table table-striped"><tbody><tr><td class="w-25"><a href="/search?search_type=products&keywords=γ-secretase" target="_parent">γ-Secretase</a></td><td class="w-25"><a href="/search?search_type=products&keywords=cannabinoid+receptors+CB">Cannabinoid Receptors</a></td><td class="w-25"><a href="/search?search_type=products&keywords=Dopamine+Receptors" target="_parent">Dopamine Receptors</a> </td><td><a href="/search?search_type=products&keywords=Excitatory+Amino+Acid+Transporter+(EAAT)" target="_parent">Excitatory Amino Acid Transporter (EAAT)</a></td></tr><tr><td><a href="/search?search_type=products&keywords=Histone+Deacetylase+(HDAC)" target="_parent">Histone Deacetylase (HDAC)</a></td><td><a href="/search?search_type=products&keywords=Muscarinic+Acetylcholine+Receptor" target="_parent">Muscarinic Acetylcholine Receptor (mAChR)</a></td><td><a href="/search?search_type=products&keywords=Opioid+Receptors" target="_parent">Opioid Receptors</a></td><td><a href="/search?search_type=products&keywords=Piezo+Channels" target="_parent">Piezo Channels</a> </td></tr><tr><td><a href="/search?search_type=products&keywords=RAGE" target="_parent">RAGE</a></td><td><a href="/search?search_type=products&keywords=Rev-Erb+Receptors" target="_parent">Rev-Erb Receptors</a></td><td><a href="/search?search_type=products&keywords=Transient+Receptor+Potential+(TRP)+Channels" target="_parent">Transient Receptor Potential (TRP) Channels</a> </td><td><a href="/search?search_type=products&keywords=Voltage-gated+Calcium+Channels+(CaV)" target="_parent">Voltage-gated Calcium (Ca<sub>V</sub>) Channels</a></td></tr></tbody></table></figure><p> </p></div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-view-full-list-of-neuroscience-targets23" role="button" aria-expanded="false" aria-controls="expPara"> <h5>View Full List of Neuroscience Targets</h5> </a> </div> <div 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target="_parent">GABA-B</a></td><td> </td><td> </td></tr></tbody></table></figure></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="products"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--clickable-icons-container paragraph--view-mode--default"> <div class="container"> <div class="row"> <div class="col p-0 "> <h2>Products and Services for Neuroscience Research</h2> </div> </div> <div class="row"> <div class="col "> </div> </div> <div class="row"> <div class="row"> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="/reagents/rnascope-ish-technology" > <div><article> <div><img 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<div><h2>Neuroscience Background Information</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a href="#synaptic">Synaptic Transmission</a> |<a href="#action"> Action Potentials</a> | <a href="#developmental">Developmental Neuroscience</a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>Two major areas of neuroscience research, Molecular and Cellular neuroscience and Developmental neuroscience, have provided the foundation for understanding brain disease mechanisms and developing therapeutic approaches for a wide range of conditions including <a href="/research-areas/neuroscience/neurodegeneration">Neurodegenerative</a> and Neuroinflammatory diseases. Neurodegenerative diseases, or conditions leading to the irreversible loss of nerves and concomitant loss of function, impact the health of millions of people around the globe. Among these, Alzheimer’s and Parkinson’s disease constitute the leading cause of dementia worldwide.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h3>Molecular and Cellular Neuroscience </h3><p>Molecular and Cellular Neuroscience focuses on the molecules and genes controlling brain cellular function.</p><h4> </h4><h4><a name="synaptic"></a>Synaptic Transmission</h4><p>Neurotransmission, or synaptic transmission, refers to the passage of signals from one neuron to another, allowing the spread of information via the propagation of action potentials. This process is the basis of communication between neurons within, and between, the peripheral and central nervous systems, and is vital for memory and cognition, muscle contraction and co-ordination of organ function.</p><p>The majority of neurotransmission occurs across chemical synapses, where an endogenous neurotransmitter is released by the presynaptic neuron and detected by receptors on the postsynaptic neuron. Neurotransmitters can be broadly split into three categories; amino acids including <a href="/search?search_type=products&keywords=glutamate">glutamate</a> and <a href="/search?search_type=products&keywords=glycine">glycin</a>e, amines including <a href="/search?search_type=products&keywords=dopamine">dopamine</a> (DA), <a href="/search?search_type=products&keywords=serotonin">serotonin</a> (5-HT; ) and <a href="/search?search_type=products&keywords=norepinephrine">norepinephrine</a> (NE), and peptides such as <a href="/search?search_type=products&keywords=dynorphin">dynorphin</a>, the <a href="/search?search_type=products&keywords=enkephalin">enkephalins</a> and <a href="/search?search_type=products&keywords=neuropeptide+y">neuropeptide Y</a>.</p><p>While the amino acids glutamate and glycine are found in all cells of the body, other neurotransmitters are only synthesized by neurons. Following synthesis, neurotransmitters are taken up and stored in synaptic vesicles, ready for release. The release of a neurotransmitter is triggered by the arrival of action potentials in the axon terminal of the presynaptic neuron, opening voltage-gated Ca<sup>2+</sup> channels and allowing influx of ions. The resulting elevation in intracellular Ca<sup>2+</sup> concentration causes synaptic vesicles to merge with the presynaptic membrane, releasing the neurotransmitter into the synaptic cleft by exocytosis.</p><p>Neurotransmitters cross the synaptic cleft and bind to their specific receptors. These maybe ligand-gated ion channels (LGICs) or <a href="/research-areas/gpcrs">G protein-coupled receptors</a> (GPCRs), with some neurotransmitters having receptors in both categories. Binding of a neurotransmitter to a LGIC causes a conformational change in the structure of the protein, allowing the passage of ions through the channel. Passage of ions through channels that are selective for positively-charged cations results in depolarization of the postsynaptic membrane and initiation of an action potential in the postsynaptic neuron. In contrast, passage of ions through negatively-charged, anion selective channels results in hyperpolarization of the postsynaptic membrane, so inhibiting action potential initiation. Binding of a neurotransmitter to a GPCR results in the activation of G proteins, which are then able to act on enzymes to modulate intracellular signaling pathways. The end result of this is the modulation of activity of other proteins, including ion channels and enzymes.</p><p>Once a neurotransmitter has bound to its receptor, it is cleared from the synaptic cleft to allow another wave of synaptic transmission. Neurotransmitter molecules are taken up by the presynaptic neuron, or by other cell types such as astrocytes, via specific reuptake transporters. Neurotransmitters may then be metabolized to be reused for further production, or they can be recycled into synaptic vesicles.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/neuroscience-research-figure-3-v4.png" alt="Illustration of the process of neurotransmission between presynaptic and postsynaptic neuron" loading="lazy" > </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>This above schematic shows the main events during dopaminergic, glutamatergic, <a href="/search?search_type=products&keywords=opioid">opioid peptide</a> and serotonergic neurotransmission. DA and 5-HT are both biogenic amines that are derived from amino acids, while glutamate itself is an amino acid and opioid peptides are cleaved from precursor proteins. All neurotransmitters undergo exocytosis from the presynaptic membrane and cross the synaptic cleft where they bind to their specific receptors. These receptors may be ligand-gated ion channels, such as ionotropic glutamate receptors, or G protein-coupled receptors, such as all subtypes of opioid receptor. Passage of ions through a ligand gated ion channel alters the excitability of a neuron. The action of neurotransmitters at GPCRs alters intracellular signaling pathways, with the specific pathway being dependent on the G protein-coupled to the receptor.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h4><a name="action"></a>Action Potentials</h4><p>An action potential is the signal that conveys information along a neuron and is also the trigger for release of a neurotransmitter at a synapse. Physically, an action potential is the rapid reversal of the resting membrane potential, caused by opening and closing of voltage-gated ion channels. At rest, the cytosol of a neuron is negatively charged (polarized) with respect to extracellular fluid, due to the distribution of ions across the cell membrane./p></p><p>An action potential is initiated by the opening of <a href="/search?search_type=products&keywords=Nav+channel">voltage-gated Na<sup>+</sup> channels</a> (Na<sub>v</sub> channels) allowing influx of Na<sup>+</sup> down its concentration gradient. This depolarizes the cell membrane past the threshold for action potential initiation. As Na<sub>v </sub>channels become inactivated, preventing the flow of Na<sup>+</sup>, <a href="/search?search_type=products&keywords=Kv+channels">voltage-gated potassium channels</a> (K<sub>v </sub>channels) open allowing the efflux of K<sup>+</sup>. This causes repolarization of the cell membrane, as the balance of ion movement across the membrane leads to the cytosol being more negatively charged than extracellular fluid. When K<sub>v</sub> channels are open the cell membrane is highly permeable to K<sup>+</sup>, but permeability to Na+ is low as Na<sub>v</sub> channels are still inactivated. This leads to a period of hyperpolarization until K<sub>v</sub> channel close, and the resting membrane potential is re-established.</p><p>Propagation of an action potential occurs as a wave of depolarization that spreads along an axon. When an area of the membrane becomes depolarized, it opens neighboring Na<sub>v</sub> channels, which then allow depolarization of that section of the membrane. The inactivation of Na<sub>v</sub> channels in the preceding section of membrane ensures that an action potential travels in only one direction alone an axon. Some axons in the central nervous system have a sheath around them, composed of myelin, which acts as an electrical insulator. Na<sub>v</sub> and K<sub>v</sub> channels are localized on gaps in the myelin sheath, known as nodes of Ranvier. Myelination increases that speed of action potential propagation as the action potential effectively ‘hops’ along an axon, occurring only at nodes of Ranvier in a process known as saltatory conduction.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h3><a name="developmental"></a>Developmental Neuroscience</h3><p>Developmental neuroscience studies the formation of the nervous system, from cellular components to how these are organized in major functional networks.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/developmental-neuroscience-figure-1.png" alt="Illustration of human brain development " loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </div> </section> </main> </div> <div 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