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.vn-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;height:3rem;margin:0 auto;max-width:77.5rem;z-index:1}@media(min-width:64rem){.vn-wrapper .vn-container{height:4.6875rem}}.vn-wrapper .vn-container.lite{max-width:100%}@media(min-width:64rem){.vn-wrapper .vn-container.lite{height:3.5rem}}.vn-wrapper .vn-menu-btn{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background:none;border:0;color:#fff;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;height:100%;line-height:1;padding:0}.vn-wrapper .vn-menu-btn:not(.lite){margin-right:1.166875rem}@media(min-width:64rem){.vn-wrapper .vn-menu-btn:not(.lite){margin-right:0}}.vn-wrapper .vn-menu-btn i{font-size:2.25rem;width:2.25rem;overflow:hidden}.vn-wrapper .vn-menu-btn svg{fill:currentColor;pointer-events:none}.vn-wrapper .vn-menu-btn.vn-search 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.vn-logo-container .vn-logo img:not(.lite){width:7.25rem}}.vn-wrapper .vn-logo-container.with-program .vn-logo img{height:.875rem}@media(min-width:64rem){.vn-wrapper .vn-logo-container.with-program .vn-logo img{height:1.4375rem}}.vn-wrapper .vn-logo-container.with-program .vn-prog-logo img{height:.9375rem}@media(min-width:64rem){.vn-wrapper .vn-logo-container.with-program .vn-prog-logo img{height:1.5625rem}}.vn-wrapper .vn-links{background:#f9f9fc;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;height:calc(100vh - 3rem);left:-140vw;overflow:auto;padding:.5rem;position:fixed;top:3rem;-webkit-transition:left .5s ease;transition:left .5s ease;width:100%;z-index:100}@media(min-width:37.5rem){.vn-wrapper .vn-links{max-width:25rem}}@media(min-width:64rem){.vn-wrapper .vn-links.lite{height:calc(100vh - 3.5rem);top:3.5rem}}@media(min-width:64rem){.vn-wrapper 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.vn-menu-section{left:0;opacity:1;visibility:visible}}@media(min-width:81.25rem){.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:not(:nth-child(7)){margin-right:1rem}}.vn-wrapper .vn-links .vn-menu-section{background:#f9f9fc;height:calc(100vh - 3rem);right:-140vw;overflow:auto;padding:0 1.5rem 6.25rem 1.5rem;position:fixed;top:3rem;-webkit-transition:all .5s ease;transition:all .5s ease;width:100%;z-index:10}.vn-wrapper .vn-links .vn-menu-section.lite{height:calc(100vh - 3.5rem);top:3.5rem}@media(min-width:37.5rem){.vn-wrapper .vn-links .vn-menu-section{max-width:25rem;left:-140vw;right:auto}.vn-wrapper .vn-links .vn-menu-section.open{left:0;right:auto}}.vn-wrapper .vn-links .vn-menu-section.open{right:0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header{-webkit-box-align:center;-ms-flex-align:center;align-items:center;border-bottom:1px solid #c6cedb;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;padding:.75rem 0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header h3{color:#1b1b1b;font-size:1.25rem;line-height:1;margin:0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header a{color:#3557ff;font-weight:400;text-decoration:none}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header a img{margin-right:.5rem;width:.8125rem}.vn-wrapper .vn-links .vn-menu-section ul{margin:.75rem 0;list-style:none;padding:0}.vn-wrapper .vn-links .vn-menu-section ul li{font-size:1.125rem;font-weight:400}.vn-wrapper .vn-links .vn-menu-section ul li a{color:#1b1b1b;display:block;padding:.75rem 0;text-decoration:none}.vn-wrapper .vn-links .vn-menu-section ul li a:hover{color:#3557ff}.vn-wrapper .vn-links .vn-menu-section ul li hr{border:1px solid #c6cedb}@media(min-width:64rem){.vn-wrapper .vn-links .vn-menu-section:not(.lite){background:#fff;border-radius:0 0 5px 5px;border-top:0;left:-20px;margin-left:-3.75rem;max-width:none;height:auto;opacity:0;padding:1.875rem 2.875rem;position:absolute;top:4.6875rem;width:18.75rem;visibility:hidden}.vn-wrapper .vn-links .vn-menu-section:not(.lite) hr{display:none}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul{margin:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li{border-bottom:1px solid #c6cedb}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li:last-of-type{border-bottom:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li.vn-see-all a{-webkit-box-align:baseline;-ms-flex-align:baseline;align-items:baseline;color:#3557ff;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:start;-ms-flex-pack:start;justify-content:flex-start}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li.vn-see-all a img{height:.75rem;margin-right:.5rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1{width:60.875rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul{-webkit-columns:4;-moz-columns:4;columns:4;-webkit-column-gap:2.875rem;-moz-column-gap:2.875rem;column-gap:2.875rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(7),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(14),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(21){border-bottom:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3{width:35rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul{-webkit-columns:2;-moz-columns:2;columns:2;-webkit-column-gap:2.875rem;-moz-column-gap:2.875rem;column-gap:2.875rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul li:nth-child(8),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul li:nth-child(16){border-bottom:0}}@media(min-width:64rem)and (max-width:81.25rem){.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1{margin-left:-8.75rem}}.vn-wrapper .vn-links .vn-back{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background:none;border:0;color:#3557ff;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;padding:1rem 0}.vn-wrapper .vn-links .vn-back i{font-size:.75rem;margin-right:.3125rem}.vn-wrapper .vn-links .vn-actions{margin-top:1rem}@media(min-width:64rem){.vn-wrapper .vn-links .vn-actions:not(.lite){-webkit-box-align:center;-ms-flex-align:center;align-items:center;border-left:1px solid #cccce7;display:-webkit-box;display:-ms-flexbox;display:flex;margin:1.1875rem 0;padding-left:1.25rem}}@media(min-width:64rem){.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe{border-left:none}}.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe .vn-signin{padding-left:.9375rem}@media(min-width:64rem){.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe .vn-signin{padding-left:0}}.vn-wrapper .vn-links .vn-actions .vn-signin{color:#3557ff;font-weight:600;padding:0 1.5rem;text-decoration:none}@media(min-width:64rem){.vn-wrapper .vn-links .vn-actions .vn-signin:not(.lite){-webkit-box-align:center;-ms-flex-align:center;align-items:center;color:#fff;display:-webkit-box;display:-ms-flexbox;display:flex;font-size:1.0625rem;padding:0;margin:0 .9375rem;-webkit-transition:all .3s ease;transition:all .3s ease}}.vn-wrapper .vn-links .vn-actions .vn-loggedin{background:none;border:0;color:#3557ff;font-weight:600;height:3rem;padding:0 1.5rem;text-decoration:none}@media(min-width:64rem){.vn-wrapper .vn-links .vn-actions .vn-loggedin:not(.lite){-webkit-box-align:center;-ms-flex-align:center;align-items:center;color:#fff;display:-webkit-box;display:-ms-flexbox;display:flex;font-size:0;padding:0;margin:0 1.25rem}.vn-wrapper .vn-links .vn-actions .vn-loggedin:not(.lite):before{background:url(//img.lb.wbmdstatic.com/webmd_static_vue/091e9c5e81e4870f/client/img/person.59072d56.svg) 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PharmD"},"dateModified":"11/06/2024 00:00:00","publisher":{"@type":"Organization","name":"WebMD","logo":{"@type":"ImageObject","url":"https://img.lb.wbmdstatic.com/vim/live/webmd/consumer_assets/site_images/logos/webmd/web/webmd_logo_53x12.gif"}}}</script><div class="inner-article-container"><header><h1>Your Guide to Vyvgart for Generalized Myasthenia Gravis</h1></header><div class="med-wrap"><div><div class="asset-med-rev"><div class="reviewer-info" data-chronicle="091e9c5e81e48710" data-e2e="asset-medical-review" data-metrics-module="rvdby-lnk"><span class="reviewer-photo-cont"><figure><img src="https://img.lb.wbmdstatic.com/vim/live/webmd/consumer_assets/site_images/articles/biographies/ratini_melinda_382x382.jpg?resize=51px:51px&output-quality=75" class="reviewer-photo"></figure></span><span class="reviewer-txt seperatorLine">Medically Reviewed by <a class="person" href="https://www.webmd.com/bio/melinda-ratini" data-metrics-link="0">Melinda Ratini, MS, DO</a><span class="no-link"></span><span class="revDate"> on November 06, 2024</span></span></div><div class="byline"><span><span class="authors" data-metrics-module="wrtnby-lnk">Written by <a href="https://www.webmd.com/bio/katayoun-sabet" class="person" data-metrics-link="0">Katayoun Sabet, PharmD</a></span></span></div></div></div></div><aside class="oncology-article-nav" data-metrics-module="cwnav-art"><ul class="nav-items desktop"><li><a href="#73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-1-2">How Does Vyvgart Work in gMG?</a></li><li><a href="#73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-1-3">Is Vyvgart Right for Me?</a></li><li><a href="#73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-1-4">How Was Vyvgart Studied for Treating gMG?</a></li><li><a href="#73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-2-7">What Are the Serious Side Effects of Vyvgart That I Should Be Aware Of?</a><div class="item-button"><a href="#"></a></div></li><li><a href="#73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-4-10">How Do I Know if Vyvgart Is Working?</a></li><li><a href="#73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-4-11">How Do Other Medicines Interact With Vyvgart?</a></li><li><a href="#73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-4-12">How Can I Get Vyvgart?</a></li><li class="item-button"></li></ul></aside><div class="reading-wrapper"><div class="readtime"><span>6 min read</span></div><div id="audio-placeholder-73da7281-5f6a-44a5-b209-4e0bb9ce7dbf"></div></div><div class="article__body" data-metrics-module="embd-lnk"><div class="article-page active-page" data-page="1"><section><p><a href="https://www.webmd.com/drugs/2/drug-183215/vyvgart-intravenous/details"><span lang="EN">Vyvgart (efgartigimod alfa-fcab)</span></a><span lang="EN"> is a prescription medicine for certain types of </span><a href="https://www.webmd.com/brain/understanding-myasthenia-gravis-basics"><span lang="EN">generalized myasthenia gravis (gMG)</span></a><span lang="EN">. It is a protein made in a lab (specifically, it is monoclonal antibody). </span><span>Vyvgart is FDA approved</span><span lang="EN"> for the treatment of gMG in adults who have antibodies against a protein called the acetylcholine receptor (AChR). It is given once a week </span><span>in four-week cycles as an infusion into a vein or as an injection under the skin.</span></p></section><section><h2 class="jumplink-headers" id="73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-1-2">How Does Vyvgart Work in gMG?</h2><p><span lang="EN">gMG is an </span><a href="https://www.webmd.com/a-to-z-guides/autoimmune-diseases"><span lang="EN">autoimmune disease</span></a><span lang="EN"> where the immune system mistakenly damages the connections between your nerves and muscles. This weakens your muscles and affects how they work. In people with gMG, the immune system blocks AChR, which is important for connecting nerves and muscles. The </span><a href="https://www.webmd.com/cold-and-flu/immune-system-function"><span lang="EN">immune system</span></a><span lang="EN"> does this using a group of antibodies.</span></p><p><span lang="EN">Vyvgart attaches to a part of these antibodies, called neonatal Fc receptors (FcRn), which protects them from being destroyed. This lowers the amount of the antibodies in the blood and helps restore the connection between nerves and muscles.</span></p></section><section><h2 class="jumplink-headers" id="73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-1-3">Is Vyvgart Right for Me?</h2><p><span lang="EN">Vyvgart may be the right choice for you if: </span></p><ul><li><span lang="EN">You are an adult with gMG.</span></li><li><span lang="EN">You have antibodies for AChR.</span></li></ul><p><span lang="EN">Your doctor will test you for AChR antibodies and review your medical history to decide if Vyvgart is right for you.</span></p></section><section><h2 class="jumplink-headers" id="73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-1-4">How Was Vyvgart Studied for Treating gMG?</h2><p><span lang="EN">One clinical study, the ADAPT trial, was done to look at the benefits and risks of Vyvgart in people with advanced gMG. The main question the study wanted to answer was: How well does Vyvgart improve symptoms in people with gMG who have antibodies for AChR?</span></p><p><span lang="EN">To learn this, the researchers measured the effect of Vyvgart using a test called the Myasthenia Gravis-Specific Activities of Daily Living scale (MG-ADL), which shows how gMG affects daily activities. A higher score means gMG has a bigger impact on those activities.</span></p><p><span lang="EN"><strong>What medicines did the people in the study take?</strong></span></p><p><span lang="EN">People in the study were randomly selected to take either Vyvgart or a placebo. The placebo looked like Vyvgart but didn’t contain any medicine. Neither the people in the study nor the doctors knew who received Vyvgart and who got the placebo. </span></p></section></div><div class="article-page " data-page="2"><section> <p><span lang="EN"><strong>Who was included in the study?</strong></span></p><p><span lang="EN">To take part in the study, people had to:</span></p><ul><li><span lang="EN">Be at least 18 years old</span></li><li><span lang="EN">Have class 2 to 4 myasthenia gravis that affects the muscles all over the body</span></li><li><span lang="EN">Have a score of 5 or higher on the MG-ADL test</span></li><li><span lang="EN">Be taking other medicines for myasthenia gravis for a period of time before the study</span></li></ul><p><span lang="EN"><strong>Who was excluded from the study?</strong></span></p><p><span lang="EN">People could not be in this study if they:</span></p><ul><li><span lang="EN">Had gotten other medicines that affected their immune system within six months of the study</span></li><li><span lang="EN">Had hepatitis B or antibodies for hepatitis C or HIV</span></li></ul><p><span lang="EN"><strong>What was the study population?</strong></span></p><ul><li><span lang="EN">167 people were in the study.</span></li><li><span lang="EN">Eighty-four people got Vyvgart, and 83 people got the placebo.</span></li><li><span lang="EN">About 71% were female.</span></li><li><span lang="EN">Most of the people in the study (77%) had antibodies for AChR.</span></li><li><span lang="EN">The average age of the people in the study was 46 (from ages 19 to 81). </span></li><li><span lang="EN">Among the people who got Vyvgart, about 82% were White, 11% Asian, 4% Black, and 4% Other.</span></li></ul></section><section><pagebreak /> <p><span lang="EN"><strong>How long was the study?</strong></span></p><p><span lang="EN">People got Vyvgart or the placebo for about 6.5 months (26 weeks). </span></p><p><span lang="EN"><strong>What was the main benefit of Vyvgart? </strong></span></p><p><span lang="EN">Vyvgart was much more effective at improving gMG symptoms compared to the placebo. About 68% of the people who took Vyvgart could perform their daily activities better, compared to about 30% of those who got the placebo. </span></p></section><section><h2 class="jumplink-headers" id="73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-2-7">What Are the Serious Side Effects of Vyvgart That I Should Be Aware Of?</h2><p><span lang="EN">Serious side effects that may happen when you get your Vyvgart treatment are:</span></p><p><span lang="EN"><strong>Allergic reactions (hypersensitivity reactions). </strong>You may have allergic reactions to Vyvgart, like rashes, swelling under the skin, and shortness of breath. These reactions are usually mild and can happen within one hour to three weeks after a Vyvgart treatment.</span></p><p><span lang="EN">Some people have had serious allergic reactions, including trouble breathing or a drop in blood pressure that caused them to faint. </span></p><p><span lang="EN"><strong>Infusion reactions. </strong>You may have reactions during or after your Vyvgart infusion, including high blood pressure, chills, shivering, and pain in your chest, stomach, or back. </span></p></section></div><div class="article-page " data-page="3"><section> <p><span lang="EN">Your health care provider will watch you for signs of an allergic reaction or an infusion reaction during the infusion and for one hour afterward. They will treat any symptoms or stop the infusion if needed. </span></p><p><span lang="EN"><strong>Contact your health care provider right away if you have symptoms of an allergic reaction or infusion reaction when you are outside the clinic.</strong></span></p><p><span><strong>Injection site reaction. </strong>One of the most common side effects of Vyvgart injection is an injection site reaction — a reaction where the needle went in your skin. Injection site reactions include rash, skin redness, itching, bruising, pain, and hives.</span><br /><span>Most often these reactions are mild to moderate, happen within about four hours of the injection, and need no treatment.</span></p><p><span lang="EN"><strong>Infections.</strong> Vyvgart may cause you to get more infections. </span></p><p><span lang="EN">The most common side effects </span><span>of Vyvgart, besides injection site reactions, are</span><span lang="EN">: </span></p><p><span lang="EN"><strong>Infections in your sinuses, throat, airways, or lungs (respiratory tract infections).</strong> If you have a fever, chills, cough, runny nose, sinus pain, or headache, drink plenty of fluids and get some rest. Your doctor may recommend nonprescription pain medicines, like acetaminophen, or cough and cold medicines.<strong> </strong>Avoid being around people who are sick, and stay away from crowded places, especially during cold and flu season. Wear a well-fitting mask in busy areas for added safety.</span></p></section><section><pagebreak /> <p><span lang="EN"><strong>Headache. </strong>You may<strong> </strong>get headaches, including migraines. Your doctor may recommend nonprescription painkillers like acetaminophen or ibuprofen. </span></p><p><span lang="EN">Tell your health care provider if you have a fever, chills, an ongoing cough, or a headache that won’t go away.</span></p><p><span lang="EN"><strong>Bladder (urinary tract) infection. </strong>Drink plenty of water to help keep bladder infections away. Tell your health care provider if you have<strong> </strong>bladder pain, blood in your urine, need to urinate frequently, or if you feel burning or pain when you urinate.</span></p><p><span lang="EN">You may also feel muscle pain or have a tingling feeling in your body, including your mouth. These side effects are usually mild and will go away as your body gets used to Vyvgart. Tell your health care provider if they don’t go away or become bothersome.</span></p><p><span lang="EN">You can also report side effects to the drugmaker at 833-argx411 (833-274-9411), or to the FDA at 800-FDA-1088 (800-332-1088) or </span><a href="https://www.fda.gov/medwatch"><span lang="EN">www.fda.gov/medwatch</span></a><span lang="EN">.</span></p></section></div><div class="article-page " data-page="4"><section><h2 class="jumplink-headers" id="73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-4-10">How Do I Know if Vyvgart Is Working?</h2><p><span lang="EN">Your doctor will regularly check how well Vyvgart is working for your gMG by tracking your progress in performing your daily activities. They may ask you to write down your gMG symptoms after each infusion and let them know if anything changes. </span></p><p><span lang="EN">Do not stop your Vyvgart injections or change your infusion schedule unless your health care provider tells you to do so.</span></p></section><section><h2 class="jumplink-headers" id="73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-4-11">How Do Other Medicines Interact With Vyvgart?</h2><p><span lang="EN">Vyvgart affects your immune system. Tell your health care providers and pharmacist about all the other prescription and nonprescription medicines, vitamins, supplements, and herbal products you take before starting Vyvgart. </span></p><p><span lang="EN"><strong>Vaccines:</strong> Tell your health care provider you are taking Vyvgart before getting any vaccines during a Vyvgart cycle. Getting live vaccines during a Vyvgart cycle is not recommended. Some examples of live vaccines are measles, mumps, rubella, smallpox, chickenpox, and yellow fever.</span></p></section><section><h2 class="jumplink-headers" id="73da7281-5f6a-44a5-b209-4e0bb9ce7dbf-4-12">How Can I Get Vyvgart?</h2><p><span lang="EN">You will need a prescription from a neurologist, a health care provider who is an expert on the nervous system. Your neurologist will either offer you Vyvgart infusions in their office or arrange for you to get Vyvgart at a clinic.</span></p><p><span lang="EN">If you need support with payment for Vyvgart, the drugmaker may be able to help you. Check out </span><a href="https://www.vyvgart.com/gmg/support-and-resources/cost-and-coverage" rel="nofollow"><span lang="EN">www.vyvgart.com/gmg/support-and-resources/cost-and-coverage</span></a> <a rel="nofollow"><span lang="EN"></span></a><span lang="EN">to learn more about their copay program or to ask your questions about insurance. You can also contact the drugmaker at 833-Vyvgart (833-898-4278).</span></p></section></div></div><div class="related-articles" data-metrics-module="cwnav-art" data-metrics-sel="li"></div><footer><div class="pub-info-and-share-bar"><div class="article__publication-sources"><section class="asset-footer"><div class="asset-footer-top"><div class="asset-footer-buttons"><button class="sources-btn">Sources</button><button class="update-history-btn">Update History</button></div><div class="asset-footer-top-share"><div class="module module-social-share-footer" data-e2e="social-sharebar"><div class="socialshare-container" data-metrics-module="fm-shr"><div class="share-footer-container"><div class="share-text">Share</div><div class="icon-sb-footer-svg icon-sb-footer-share"><svg class="icon-sb-footer-svg" width="18" height="20" viewbox="0 0 18 20" fill="none" xmlns="https://www.w3.org/2000/svg"><path class="icon-sb-footer-svg" d="M15 20C14.1667 20 13.4583 19.7083 12.875 19.125C12.2917 18.5417 12 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Gravis.”</span></p><p><i><span lang="EN">Lancet Neurology</span></i><span lang="EN">: “Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial.”</span></p><p><span lang="EN">FDA: “FDA Approves New Treatment for Myasthenia Gravis.” </span></p></div></div></div><div class="asset-footer-bottom"><a href="https://www.webmd.com/about-webmd-policies/about-privacy-policy" class="asset-footer-policy"> View privacy policy, copyright and trust info </a></div><div class="asset-footer-bottom-share"><div class="module module-social-share-footer" data-e2e="social-sharebar"><div class="socialshare-container" data-metrics-module="fm-shr"><div class="share-footer-container"><div class="share-text">Share</div><div class="icon-sb-footer-svg icon-sb-footer-share"><svg class="icon-sb-footer-svg" width="18" height="20" viewbox="0 0 18 20" fill="none" xmlns="https://www.w3.org/2000/svg"><path 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In people with gMG, the immune system blocks AChR, which is important for connecting nerves and muscles. The \u003C\u002Fspan\u003E\u003Ca link_friendlyurl=\"https:\u002F\u002Fwww.webmd.com\u002Fcold-and-flu\u002Fimmune-system-function\"\u003E\u003Cspan lang=\"EN\"\u003Eimmune system\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan lang=\"EN\"\u003E does this using a group of antibodies.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EVyvgart attaches to a part of these antibodies, called neonatal Fc receptors (FcRn), which protects them from being destroyed. This lowers the amount of the antibodies in the blood and helps restore the connection between nerves and muscles.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Cpagebreak type=\"mobile\" order=\"2\" \u002F\u003E\u003Csection_header\u003EIs Vyvgart Right for Me?\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EVyvgart may be the right choice for you if: \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EYou are an adult with gMG.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EYou have antibodies for AChR.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EYour doctor will test you for AChR antibodies and review your medical history to decide if Vyvgart is right for you.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Csection_header\u003EHow Was Vyvgart Studied for Treating gMG?\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EOne clinical study, the ADAPT trial, was done to look at the benefits and risks of Vyvgart in people with advanced gMG. The main question the study wanted to answer was: How well does Vyvgart improve symptoms in people with gMG who have antibodies for AChR?\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003ETo learn this, the researchers measured the effect of Vyvgart using a test called the Myasthenia Gravis-Specific Activities of Daily Living scale (MG-ADL), which shows how gMG affects daily activities. A higher score means gMG has a bigger impact on those activities.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EWhat medicines did the people in the study take?\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EPeople in the study were randomly selected to take either Vyvgart or a placebo. The placebo looked like Vyvgart but didn’t contain any medicine. Neither the people in the study nor the doctors knew who received Vyvgart and who got the placebo. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Cpagebreak type=\"mobile\" order=\"3\" \u002F\u003E\u003Cpagebreak type=\"desktop\" order=\"2\" \u002F\u003E\u003Csection_header is_continued=\"true\"\u003EHow Was Vyvgart Studied for Treating gMG? continued...\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EWho was included in the study?\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003ETo take part in the study, people had to:\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EBe at least 18 years old\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EHave class 2 to 4 myasthenia gravis that affects the muscles all over the body\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EHave a score of 5 or higher on the MG-ADL test\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EBe taking other medicines for myasthenia gravis for a period of time before the study\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EWho was excluded from the study?\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EPeople could not be in this study if they:\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EHad gotten other medicines that affected their immune system within six months of the study\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EHad hepatitis B or antibodies for hepatitis C or HIV\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EWhat was the study population?\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cul\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003E167 people were in the study.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EEighty-four people got Vyvgart, and 83 people got the placebo.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EAbout 71% were female.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EMost of the people in the study (77%) had antibodies for AChR.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EThe average age of the people in the study was 46 (from ages 19 to 81). \u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003Cli\u003E\u003Cspan lang=\"EN\"\u003EAmong the people who got Vyvgart, about 82% were White, 11% Asian, 4% Black, and 4% Other.\u003C\u002Fspan\u003E\u003C\u002Fli\u003E\u003C\u002Ful\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Cpagebreak type=\"mobile\" order=\"4\" \u002F\u003E\u003Cpagebreak \u002F\u003E\u003Csection_header is_continued=\"true\"\u003EHow Was Vyvgart Studied for Treating gMG? continued...\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EHow long was the study?\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EPeople got Vyvgart or the placebo for about 6.5 months (26 weeks). \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EWhat was the main benefit of Vyvgart? \u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EVyvgart was much more effective at improving gMG symptoms compared to the placebo. About 68% of the people who took Vyvgart could perform their daily activities better, compared to about 30% of those who got the placebo. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Csection_header\u003EWhat Are the Serious Side Effects of Vyvgart That I Should Be Aware Of?\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003ESerious side effects that may happen when you get your Vyvgart treatment are:\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EAllergic reactions (hypersensitivity reactions). \u003C\u002Fstrong\u003EYou may have allergic reactions to Vyvgart, like rashes, swelling under the skin, and shortness of breath. These reactions are usually mild and can happen within one hour to three weeks after a Vyvgart treatment.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003ESome people have had serious allergic reactions, including trouble breathing or a drop in blood pressure that caused them to faint. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EInfusion reactions. \u003C\u002Fstrong\u003EYou may have reactions during or after your Vyvgart infusion, including high blood pressure, chills, shivering, and pain in your chest, stomach, or back. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Cpagebreak type=\"mobile\" order=\"5\" \u002F\u003E\u003Cpagebreak type=\"desktop\" order=\"3\" \u002F\u003E\u003Csection_header is_continued=\"true\"\u003EWhat Are the Serious Side Effects of Vyvgart That I Should Be Aware Of? continued...\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EYour health care provider will watch you for signs of an allergic reaction or an infusion reaction during the infusion and for one hour afterward. They will treat any symptoms or stop the infusion if needed. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EContact your health care provider right away if you have symptoms of an allergic reaction or infusion reaction when you are outside the clinic.\u003C\u002Fstrong\u003E\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan\u003E\u003Cstrong\u003EInjection site reaction. \u003C\u002Fstrong\u003EOne of the most common side effects of Vyvgart injection is an injection site reaction — a reaction where the needle went in your skin. Injection site reactions include rash, skin redness, itching, bruising, pain, and hives.\u003C\u002Fspan\u003E\u003Cbr \u002F\u003E\u003Cspan\u003EMost often these reactions are mild to moderate, happen within about four hours of the injection, and need no treatment.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EInfections.\u003C\u002Fstrong\u003E Vyvgart may cause you to get more infections. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EThe most common side effects \u003C\u002Fspan\u003E\u003Cspan\u003Eof Vyvgart, besides injection site reactions, are\u003C\u002Fspan\u003E\u003Cspan lang=\"EN\"\u003E: \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EInfections in your sinuses, throat, airways, or lungs (respiratory tract infections).\u003C\u002Fstrong\u003E If you have a fever, chills, cough, runny nose, sinus pain, or headache, drink plenty of fluids and get some rest. Your doctor may recommend nonprescription pain medicines, like acetaminophen, or cough and cold medicines.\u003Cstrong\u003E \u003C\u002Fstrong\u003EAvoid being around people who are sick, and stay away from crowded places, especially during cold and flu season. Wear a well-fitting mask in busy areas for added safety.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Cpagebreak type=\"mobile\" order=\"6\" \u002F\u003E\u003Cpagebreak \u002F\u003E\u003Csection_header is_continued=\"true\"\u003EWhat Are the Serious Side Effects of Vyvgart That I Should Be Aware Of? continued...\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EHeadache. \u003C\u002Fstrong\u003EYou may\u003Cstrong\u003E \u003C\u002Fstrong\u003Eget headaches, including migraines. Your doctor may recommend nonprescription painkillers like acetaminophen or ibuprofen. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003ETell your health care provider if you have a fever, chills, an ongoing cough, or a headache that won’t go away.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EBladder (urinary tract) infection. \u003C\u002Fstrong\u003EDrink plenty of water to help keep bladder infections away. Tell your health care provider if you have\u003Cstrong\u003E \u003C\u002Fstrong\u003Ebladder pain, blood in your urine, need to urinate frequently, or if you feel burning or pain when you urinate.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EYou may also feel muscle pain or have a tingling feeling in your body, including your mouth. These side effects are usually mild and will go away as your body gets used to Vyvgart. Tell your health care provider if they don’t go away or become bothersome.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EYou can also report side effects to the drugmaker at 833-argx411 (833-274-9411), or to the FDA at 800-FDA-1088 (800-332-1088) or \u003C\u002Fspan\u003E\u003Ca link_friendlyurl=\"https:\u002F\u002Fwww.fda.gov\u002Fmedwatch\"\u003E\u003Cspan lang=\"EN\"\u003Ewww.fda.gov\u002Fmedwatch\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan lang=\"EN\"\u003E.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Cpagebreak type=\"mobile\" order=\"7\" \u002F\u003E\u003Cpagebreak type=\"desktop\" order=\"4\" \u002F\u003E\u003Csection_header\u003EHow Do I Know if Vyvgart Is Working?\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EYour doctor will regularly check how well Vyvgart is working for your gMG by tracking your progress in performing your daily activities. They may ask you to write down your gMG symptoms after each infusion and let them know if anything changes. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EDo not stop your Vyvgart injections or change your infusion schedule unless your health care provider tells you to do so.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Csection_header\u003EHow Do Other Medicines Interact With Vyvgart?\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EVyvgart affects your immune system. Tell your health care providers and pharmacist about all the other prescription and nonprescription medicines, vitamins, supplements, and herbal products you take before starting Vyvgart. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003E\u003Cstrong\u003EVaccines:\u003C\u002Fstrong\u003E Tell your health care provider you are taking Vyvgart before getting any vaccines during a Vyvgart cycle. Getting live vaccines during a Vyvgart cycle is not recommended. Some examples of live vaccines are measles, mumps, rubella, smallpox, chickenpox, and yellow fever.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E\u003Csection_group\u003E\u003Csection_header\u003EHow Can I Get Vyvgart?\u003C\u002Fsection_header\u003E\u003Csection_text\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EYou will need a prescription from a neurologist, a health care provider who is an expert on the nervous system. Your neurologist will either offer you Vyvgart infusions in their office or arrange for you to get Vyvgart at a clinic.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EIf you need support with payment for Vyvgart, the drugmaker may be able to help you. Check out \u003C\u002Fspan\u003E\u003Ca link_friendlyurl=\"https:\u002F\u002Fwww.vyvgart.com\u002Fgmg\u002Fsupport-and-resources\u002Fcost-and-coverage\" rel=\"nofollow\"\u003E\u003Cspan lang=\"EN\"\u003Ewww.vyvgart.com\u002Fgmg\u002Fsupport-and-resources\u002Fcost-and-coverage\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Ca rel=\"nofollow\"\u003E\u003Cspan lang=\"EN\"\u003E\u003C\u002Fspan\u003E\u003C\u002Fa\u003E\u003Cspan lang=\"EN\"\u003Eto learn more about their copay program or to ask your questions about insurance. You can also contact the drugmaker at 833-Vyvgart (833-898-4278).\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003C\u002Fsection_text\u003E\u003Chighlights\u003E\u003C\u002Fhighlights\u003E\u003Cpull_quotes\u003E\u003C\u002Fpull_quotes\u003E\u003C\u002Fsection_group\u003E"},"citations":{"#cdata-section":"\u003Cp\u003E\u003Cspan lang=\"EN\"\u003ESOURCES:\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EVyvgart (argenx U.S.) Patient Information. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EVyvgart (argenx U.S.) Prescribing Information.\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EVyvgart (argenx U.S.).\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EVyvgart HCP. \u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Ci\u003E\u003Cspan lang=\"EN\"\u003EJournal of Clinical Medicine\u003C\u002Fspan\u003E\u003C\u002Fi\u003E\u003Cspan lang=\"EN\"\u003E: “New Targeted Agents in Myasthenia Gravis and Future Therapeutic Strategies.”\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003ENational Institute of Neurological Disorders and Stroke: “Myasthenia Gravis.”\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Ci\u003E\u003Cspan lang=\"EN\"\u003ELancet Neurology\u003C\u002Fspan\u003E\u003C\u002Fi\u003E\u003Cspan lang=\"EN\"\u003E: “Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial.”\u003C\u002Fspan\u003E\u003C\u002Fp\u003E\u003Cp\u003E\u003Cspan lang=\"EN\"\u003EFDA: “FDA Approves New Treatment for Myasthenia Gravis.” \u003C\u002Fspan\u003E\u003C\u002Fp\u003E"},"related_links_header":"","related_links_text":{"#cdata-section":""}}}}}},"staticPublicPath":"\u002Fstatic_vue\u002F091e9c5e81e4870f\u002Fclient\u002F","isInteractivePage":false},"flow":{"flowInfo":false},"quiz":{"rmq":{}}}</script> <script>window.__INITIAL_STATE__.route.hash = window.location.hash; window.__INITIAL_STATE__.route.fullPath = window.location.pathname; window.__INITIAL_STATE__.route.path = window.location.pathname; if(window.location.search !== ""){ var search = window.location.search.substring(1); window.__INITIAL_STATE__.route.query=JSON.parse('{"' + search.replace(/&/g, '","').replace(/=/g,'":"') + '"}', function(key, value) { return key===""?value:decodeURIComponent(value) }) } else {window.__INITIAL_STATE__.route.query={};}</script><script>try{var _comscore=_comscore||[];_comscore.push({c1:'2',c2:'6035829',options:{enableFirstPartyCookie:!0}}),function(){var e=document.createElement('script'),o=document.getElementsByTagName('script')[0];e.async=!0,e.src='https://sb.scorecardresearch.com/cs/6035829/beacon.js',o.parentNode.insertBefore(e,o),window.__INITIAL_STATE__?window.document.addEventListener('before_pv',function(){window.document.addEventListener('onAdobeOmniBeforePv',function(){window.biConsumerIsReady&&self.COMSCORE&&COMSCORE.beacon({c1:'2',c2:'6035829',options:{enableFirstPartyCookie:!0}})})},{once:!0}):window.document.addEventListener('onAdobeOmniBeforePv',function(){self.COMSCORE&&COMSCORE.beacon({c1:'2',c2:'6035829',options:{enableFirstPartyCookie:!0}})})}()}catch(e){}</script><noscript><img src='https://sb.scorecardresearch.com/p?c1=2&c2=6035829&cv=3.9.1&cj=1'></noscript>  <script id="cookieConsentScriptNonEU" async="async" src="https://img.lb.wbmdstatic.com/webmd_static_vue/file-explorer/webmd/consumer_assets/site_images/webmd-ccm/webmd-ccm-lite.min.js"></script><script type="text/javascript" async="async" importance="high" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js" id="GPT_JS"></script><script>window.webmd.googleloaded = true; window.googleloaded = true; </script> <script>window.performance.mark('page-end');</script> <link rel="stylesheet" href="//img.lb.wbmdstatic.com/webmd_static_vue/091e9c5e81e4870f/client/css/non-critical-1732570847611.f64d91a6.css"> <link rel="stylesheet" href="//img.lb.wbmdstatic.com/webmd_static_vue/091e9c5e81e4870f/client/css/pagetype-oncology-1732570847611.b84c3554.css"> </body> </html>