Biomarker Discovery with Imaging Mass Cytometry

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This is particularly true for cancer and other diseases with high tumor heterogeneity and broad cellular signatures, where classification at an individual level may be confounding. Imaging Mass Cytometry™ (IMC)™ can uncover novel phenotypes and identify therapeutic targets that may be relevant to developing biomarkers and future treatment strategies.</p> </div> <div class="d-none d-lg-block col-lg-2"></div> <div class="d-flex px-5 py-3 p-lg-0 col-12 col-lg-3 justify-content-center align-items-center"> <picture data-alt="Blue icon illustrating biomarker discovery application" data-default-src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Applications/Blue/image-thumb__10343__medium/Applcon_Blue_biomarker-discovery.png"> <source srcset="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Applications/Blue/image-thumb__10343__medium/Applcon_Blue_biomarker-discovery.png 1x, /FluidigmSite_Assets/Generic-Assets/Images/Icons-Applications/Blue/image-thumb__10343__medium/Applcon_Blue_biomarker-discovery@2x.png 2x" type="image/png" /> <img title="" class="img-fluid" alt="Blue icon illustrating biomarker discovery application" src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Applications/Blue/image-thumb__10343__medium/Applcon_Blue_biomarker-discovery.png" /> </picture> </div> <div class="d-none d-lg-block col-lg-1"></div> </div> </div> </div> </div> <div class="pimcore_area_jump-links pimcore_area_content "> <div class="jump-links-container"> <div class="jump-links bg-very-light-gray w-100"> <div class="container"> <div class="row"> <div class="col d-flex align-items-center overflow-auto py-4"> <a class="font-15 fw-bold font-proxima-nova link-no-style color-primary-gray jump-link" href="#overview-anchor" data-anchor-link="overview-anchor">Overview</a> <a class="font-15 fw-bold font-proxima-nova link-no-style color-primary-gray jump-link" href="#customer-stories-anchor" data-anchor-link="customer-stories-anchor">Customer Stories</a> <a class="font-15 fw-bold font-proxima-nova link-no-style color-primary-gray jump-link" href="#blog-anchor" data-anchor-link="blog-anchor">Related Blog Posts</a> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_large-cta pimcore_area_content "> <div id="cardio-anchor" class="large-cta "> <div class="container py-5"> <div class="row"> <div class="min-height col-12 col-lg-3 py-3 py-lg-0 bg-light-blue text-center d-flex align-items-center justify-content-center"> <h2 class="color-white text-uppercase">Featured Application</h2> </div> <div class="large-cta-border bg-white col-12 col-lg-9 p-3 p-lg-5 pb-lg-4 d-flex flex-column justify-content-between"> <div class="sidebysideContainer"> <div class="Width80"> <h3 paraeid="{7119dba4-492c-4135-a880-eaaa25f205e0}{172}" paraid="432660215"><span class="color-secondary-blue">Cardiovascular Immunology</span></h3> <hr /> <p><strong>With over 2,000 publications and 200 clinical trials, CyTOF® flow cytometry and tissue imaging can be used for a variety of immune and non-immune related diseases. Here we narrow in on an emerging area for high-parameter cytometry. </strong></p> <p>Truly understanding cardiovascular disease, a leading cause of death globally, requires single-cell technology that enables unprecedented exploration of a complex cellular landscape.</p> <p>Background can be a challenging issue when imaging cardiac tissue. Imaging Mass Cytometry, the only proven high-plex imaging with no autofluorescence, helps deliver clear insights that can provide a comprehensive view of molecular pathogenesis, signaling mechanisms and immune-mediated damage in the heart or related cardiac tissues.</p> <p><a class="secondary-btn" href="https://fluidigm.my.salesforce.com/sfc/p/#700000009DAw/a/4u0000010qZy/jxn4Y2Y4n0i8B5j13SxgGFgw.qnSqIzyT85rPNcYg1s" target="_blank">Read about how high-plex imaging uncovers spatial biology insights in cardiology disease</a></p> <p><a class="secondary-btn" href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u0000010qWV/6zXZkeff4yqj84AxRK5tiDRvjTh73b4GJWI_Inn3VO4" rel="noreferrer noopener" target="_blank">See a selection of publications featuring leading-edge cardiovascular research using Standard BioTools™ technology. </a></p> </div> <div class="Width20 sidebysideRtItem"> <h2> </h2> <h3> </h3> <a href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u0000010qWV/6zXZkeff4yqj84AxRK5tiDRvjTh73b4GJWI_Inn3VO4" target="_blank"><img src="/FluidigmSite_Assets/PrdSrv-Tech_ImagingMassCytometry/Images/IMC_Thumbnail_PublicationList_Cardio-Immuno.png" style="width: 100%; border: 1px solid #cdcdcd;" /></a></div> </div> <div class="row mt-4"> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="-anchor" class="py-5 bg-very-light-gray"> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <h3 paraeid="{7119dba4-492c-4135-a880-eaaa25f205e0}{172}" paraid="432660215">Potential indicative immunotherapy biomarker in melanoma </h3> <p paraeid="{7119dba4-492c-4135-a880-eaaa25f205e0}{180}" paraid="468603245">Martinez-Morilla and colleagues demonstrated the use of IMC to quantitatively measure 25 markers to simultaneously generate data from tumor, stroma, T cells, B cells and macrophages. Using IMC with biopsy samples from metastatic melanoma patients who received immunotherapy, the team discovered a compelling biomarker potentially indicative of treatment response in melanoma. </p> <ul> <li paraeid="{7119dba4-492c-4135-a880-eaaa25f205e0}{180}" paraid="468603245"><a class="secondary-btn" href="https://clincancerres.aacrjournals.org/content/27/7/1987" rel="noreferrer noopener" target="_blank">Read publication</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="-anchor" class="py-5 "> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <h3 paraeid="{7119dba4-492c-4135-a880-eaaa25f205e0}{225}" paraid="840304940">Answering key questions about the role of CAFs in lung cancer </h3> <p paraeid="{7119dba4-492c-4135-a880-eaaa25f205e0}{231}" paraid="1664450197">In her webinar, Handan Xiang, PhD, describes how she and the team at Merck use IMC studies to understand cancer-associated fibroblasts in tumor stroma. Learn how this research illuminated a possible therapeutic path that could potentially reverse a CAF-mediated immunosuppressive microenvironment.  </p> <ul> <li paraeid="{7119dba4-492c-4135-a880-eaaa25f205e0}{249}" paraid="373684535"><a class="secondary-btn" href="https://standard-biotools.wistia.com/medias/a6kpp57lca" target="_blank">Watch Handan Xiang's webinar</a> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="-anchor" class="py-5 bg-very-light-gray"> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <h3 paraeid="{ef7f5a41-b51c-4737-83e8-d96707592391}{11}" paraid="1539238967">Novel signaling networks identified through IMC and transcriptomics data integration </h3> <p paraeid="{ef7f5a41-b51c-4737-83e8-d96707592391}{19}" paraid="127912361">The use of IMC enabled researchers to uncover the heterogeneity of cellular phenotypes and cell-to-cell interactions in the tumor microenvironment of high-grade serous ovarian cancer to understand which interactions might influence patient survival. Learn about the pipeline used to generate PhenoGraph clusters for cell density and neighborhood analysis along with correlating the IMC phenotype with a gene expression profile. </p> <ul> <li paraeid="{ef7f5a41-b51c-4737-83e8-d96707592391}{49}" paraid="403181471"><a class="secondary-btn" href="https://www.mdpi.com/2072-6694/13/8/1777" rel="noreferrer noopener" target="_blank">Read publication</a> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="-anchor" class="py-5 "> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <h3 paraeid="{ef7f5a41-b51c-4737-83e8-d96707592391}{66}" paraid="1855938525">Unique expression signatures in Hodgkin lymphoma aid in the development of novel biomarkers </h3> <p paraeid="{ef7f5a41-b51c-4737-83e8-d96707592391}{72}" paraid="1764203425">Scientists aim to unravel the very complex tumor microenvironment (TME) of Hodgkin lymphoma by deciphering the unique immune cell architecture of the TME and for the first time unveil its phenotype. They pair IMC with single-cell transcriptome analysis and suggest implications for the development of novel therapies, including rational combinations and predictive biomarker development. </p> <ul> <li paraeid="{ef7f5a41-b51c-4737-83e8-d96707592391}{84}" paraid="797594789"><a class="secondary-btn" href="https://pubmed.ncbi.nlm.nih.gov/31857391/" rel="noreferrer noopener" target="_blank">Read publication</a> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_overlap-scroller pimcore_area_content "> <div id="customer-stories-anchor" class="bg-magenta-alt"> <div class="container-fluid pb-5 overlap-scroller "> <div class="row"> <div class="col-lg-1 d-none d-lg-block"></div> <div class="col-12 col-lg-3 pt-5 pe-2 pe-lg-3 d-flex flex-column justify-content-center color-white"> <h2 class="text-uppercase color-primary-gray pt-0">Customer Stories</h2> <p>Learn more about how our customers are leveraging Standard BioTools technology.</p> <div class="primary-btn-alt d-inline-block mt-3"> <a href="/resources/customer-stories" target="_self" title="VIEW ALL" type="internal">VIEW ALL</a> </div> </div> <div class="col-lg-1 d-none d-lg-block"></div> <div class="col-12 col-lg-7 card-container d-flex py-5 card-width-lg ps-0"> <span class="col autofocus" autofocus></span> <div class="col product-card small-p"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Yongpan Yan, PhD</h4> </div> <div class="row g-0 rounded-bottom h-100"> <div class="col-lg-4 text-center"> <picture data-alt="Spotlight IMC YONGPAN YAN" data-default-src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3201__card-thumbnail/Spotlight_IMC_Yongpan.jpg"> <source srcset="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3201__card-thumbnail/Spotlight_IMC_Yongpan.jpg 1x, 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border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Febe van Maldegem, PhD, and Karishma Valand</h4> </div> <div class="row g-0 rounded-bottom h-100"> <div class="col-lg-4 text-center"> <picture data-alt="Spotlight IMC FEBE VAN MALDEGEM, PHD, AND KARISHMA VALAND" data-default-src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3227__card-thumbnail/Spotlight_IMC_Febe.jpg"> <source srcset="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3227__card-thumbnail/Spotlight_IMC_Febe.jpg 1x, /FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3227__card-thumbnail/Spotlight_IMC_Febe@2x.jpg 2x" type="image/jpeg" /> <img alt="Spotlight IMC FEBE VAN MALDEGEM, PHD, AND KARISHMA VALAND" title="Spotlight IMC FEBE VAN MALDEGEM, PHD, AND KARISHMA VALAND" src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3227__card-thumbnail/Spotlight_IMC_Febe.jpg" /> </picture> </div> <div class="col-lg-8 d-flex flex-column"> <div class="card-body px-4 pt-4"> <h3 class="card-text pt-0">Imaging the dramatic remodeling of the lung tumor microenvironment</h3> </div> <div class="card-footer border-0 px-4 pb-3 bg-white d-flex align-items-center justify-content-end mt-auto"> <a href="https://www.standardbio.com/resources/customer-stories/Immune-response-to-kras-inhibition" class="secondary-btn">Learn more</a> </div> </div> </div> </div> </div> <div class="col product-card small-p"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Melissa Davis, PhD</h4> </div> <div class="row g-0 rounded-bottom h-100"> <div class="col-lg-4 text-center"> <picture data-alt="Spotlight IMC MELISSA DAVIS" data-default-src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3224__card-thumbnail/Spotlight_IMC_Melissa.jpg"> <source srcset="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3224__card-thumbnail/Spotlight_IMC_Melissa.jpg 1x, /FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3224__card-thumbnail/Spotlight_IMC_Melissa@2x.jpg 2x" type="image/jpeg" /> <img alt="Spotlight IMC MELISSA DAVIS" title="Spotlight IMC MELISSA DAVIS" src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3224__card-thumbnail/Spotlight_IMC_Melissa.jpg" /> </picture> </div> <div class="col-lg-8 d-flex flex-column"> <div class="card-body px-4 pt-4"> <h3 class="card-text pt-0">Defining spatial characteristics using Imaging Mass Cytometry</h3> </div> <div class="card-footer border-0 px-4 pb-3 bg-white d-flex align-items-center justify-content-end mt-auto"> <a href="https://www.standardbio.com/resources/customer-stories/breast-cancer-disparities-and-tumor-biology" class="secondary-btn">Learn more</a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="blog-anchor" class="py-5 bg-very-light-gray"> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <div class="sidebysideContainer bg-very-light-gray"> <div class="Width25"><img src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Misc/Icon_BlogPost_BlueCircle-OutlineWhite.png" style="width:80%;" /></div> <div class="Width75 sidebysideRtItem"> <h3><span class="color-secondary-blue">RELATED BLOG POSTS</span></h3> <hr /> <ul> <li><a class="secondary-btn" href="/resources/blog-articles/2024/02/transcriptomics-vs-proteomics">The power of multi-omics</a></li> <li><a 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