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srcset="https://s3.crackedcdn.com/phpimages/imageset/8/1/4/1201814_320x180.jpg"> </picture> <label class="type-label pictofact">PICTOFACT</label> </a> <div class=meta> <h2 class=title><a href="https://trivia.cracked.com/image-pictofact-13740-44-random-bits-of-trivia-that-might-be-a-little-too-stylish-for-your-brain-to-pull-off" title="44+Random+Bits+of+Trivia+That+Might+Be+A+Little+Too+Stylish+for+Your+Brain+to+Pull+Off">44 Random Bits of Trivia That Might Be A Little Too Stylish for Your Brain to Pull Off</a></h2> </div> </article> </div> </div> <div id=content-wrapper class="page-wrapper content-wrapper" data-content-index=1 data-content-id=44615 data-content-type=article data-content-form=inhouse data-content-rating=pg> <div class="page-wrapper article "> <section class=page-section> <div class=left> <section class=content-header> <h1 class=content-title>5 Useful Mutations Some Lucky Humans Have</h1> <div class=content-description> Ones that are more X-Men than X-Files </div> <figure class=image> <picture> <source media="(min-width: 700px)" srcset="https://s3.crackedcdn.com/phpimages/article/3/0/3/1198303_800x450.jpg"> <source media="(min-width: 320px)" srcset="https://s3.crackedcdn.com/phpimages/article/3/0/3/1198303_320x180.jpg"> <img src="https://s3.crackedcdn.com/phpimages/article/3/0/3/1198303_320x180.jpg" alt="5 Useful Mutations Some Lucky Humans Have" class=image-featured /> </picture> </figure> <div class=meta> <time datetime="2024-12-11 08:00:00">December 11, 2024</time> <nav class=authors> <a href="https://www.cracked.com/members/eyud29" rel=author title="Eli Yudin"> <img data-src="https://s3.crackedcdn.com/phpimages/members/avatars/9/1/111619_45_v1.png" alt="Eli Yudin" class=lozad /> <div class=author-meta> <span class=byline>Eli Yudin</span> </div> </a> </nav> </div> </section> <article><p>Thanks to superhero movies and horror stories, the word “mutation” has taken on a pretty dramatic image. But most mutations are a lot more subtle than suddenly sprouting wings, or shooting lasers out of one of your body<span style="background-color:transparent;color:#000000;">’</span>s holes. That doesn<span style="background-color:transparent;color:#000000;">’</span>t mean, though, that there aren<span style="background-color:transparent;color:#000000;">’</span>t real-life mutations that are superpowers in their own small way.</p><p>Here are five actual mutations that we<span style="background-color:transparent;color:#000000;">’</span>d all love to have…</p> <article id=entry-1 class="entry entry-article"><h2 class="subheading subheading-num"><label>5 </label><span>Dense Bones </span></h2><figure class=image><img class=lozad data-src="https://s3.crackedcdn.com/phpimages/article/3/0/8/1198308.jpg" data-media-id=1198308 width=1000 height=667><figure class=ck-img-attr><figcaption><p>Shutterstock</p></figcaption></figure></figure><p>This one<span style="background-color:transparent;color:#000000;">’</span>s straight out of the Marvel playbook, maybe more than anything else on this list. It was even discovered under the sort of circumstances that would send Charles Xavier on a home visit. There was a family in Connecticut, of which not a single member had ever broken a bone. Doctors found that the entire family had extremely high bone density, and learned <a target=_blank rel=noopener href="https://medicine.yale.edu/news/yale-medicine-magazine/article/unbreakable-bones-prompt-a-hunt-for-genes/">that it was likely a result of a gene known as LRP5</a>. </p><p>There<span style="background-color:transparent;color:#000000;">’</span>s a bit of a coin-flip involved, with LRP5 also able to cause low bone density, but it turned out if it mutated in the right way, you<span style="background-color:transparent;color:#000000;">’</span>d be left with one hell of a sturdy skeleton.</p><div class=outstream-mobile-wrapper id=outstream-mobile> <section class="ck-anyclips ck-anyclips-mobile"></section> </div> </article><article id=entry-2 class="entry entry-article"><h2 class="subheading subheading-num"><label>4 </label><span>High Altitude Tolerance </span></h2><figure class=image><img class=lozad data-src="https://s3.crackedcdn.com/phpimages/article/3/0/7/1198307.jpg" data-media-id=1198307 width=1000 height=666><figure class=ck-img-attr><figcaption><p>Shutterstock</p></figcaption></figure></figure><p><span style="background-color:transparent;">As someone who</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">s been to a wedding, with the attached alcohol consumption, 10,000 feet above sea level? I can tell you that altitude can well and truly mess you up. Most notably, due to the lack of oxygen. So what</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">s the deal with the sherpas on places like Everest who are casually trudging along while their filthy rich human cargo suck down oxygen like blue Gatorade the morning after a high-altitude wedding? </span></p><section class="page-wrapper ck-anyclips-desktop"> <section class="ck-anyclips ck-anyclips-article" id=outstream></section> </section> <p><span style="background-color:transparent;">Research found that Tibetan and Andean populations, who</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">ve lived at great heights for much of their history, have specific mutations that make them more tolerant of low oxygen levels. Namely, </span><a target=_blank rel=noopener href="https://www.science.org/content/article/genetic-variant-helps-people-living-andes-breathe-easy"><span style="background-color:transparent;">they both have differences related to the hemoglobin in their blood compared to us lowlanders</span></a><span style="background-color:transparent;">. Andeans have higher levels of hemoglobin overall, while Tibetans use the hemoglobin they have extremely efficiently.</span></p><section class="ad-wrapper ad-mobile ad-injected-mobile"> <div class=ad-inner-wrapper> <label>Advertisement</label> <div class="ad ad-300x250 ad-code"> <div id=crd_article_incontent_mediumrect_mobile_01> </div> </div> </div> </section> </article><article id=entry-3 class="entry entry-article"><h2 class="subheading subheading-num"><label>3 </label><span>Malaria Resistance </span></h2><figure class=image><img class=lozad data-src="https://s3.crackedcdn.com/phpimages/article/3/0/6/1198306.jpg" data-media-id=1198306 width=1000 height=571><figure class=ck-img-attr><figcaption><p>Shutterstock</p></figcaption></figure></figure><p><span style="background-color:transparent;">Now, one unfortunate pattern even on a positively framed list is that mutations don</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">t have a whole lot of room for error. Sometimes these lucky mutations require threading the needle gene-wise to get all of the benefits without veering into “oh no” territory. This is the case, too, with a mutation known as sickle cell. Again, we</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">re looking at hemoglobin, and specifically the shape of red blood cells. </span></p><p><span style="background-color:transparent;">Normal red blood cells are the disc-looking blobs you</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">ve probably seen, but this trait can cause some of them to have a sickle shape. If one of your two parents passes on the sickle cell gene, you</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">ll have both sickle-shaped and normal blood cells, </span><a target=_blank rel=noopener href="https://www.verywellhealth.com/sickle-cell-and-malaria-5323165"><span style="background-color:transparent;">which gives you resistance against severe malaria.</span></a><span style="background-color:transparent;"> Unfortunately, if you receive two copies of this recessive gene, </span><a target=_blank rel=noopener href="https://www.cdc.gov/sickle-cell/about/index.html"><span style="background-color:transparent;">you'll end up with sickle cell disease</span></a><span style="background-color:transparent;">, which far outweighs any possible benefits. </span></p><section class="ad-wrapper ad-desktop"> <div class=ad-inner-wrapper> <label>Advertisement</label> <div class="ad ad-300x250m728x90 inject-desktop-ad"> <div id=crd_article_incontent_leaderboard_desktop_01 class=ad-code> </div> </div> </div> </section><section class="ad-wrapper ad-mobile ad-injected-mobile"> <div class=ad-inner-wrapper> <label>Advertisement</label> <div class="ad ad-300x250 ad-code"> <div id=crd_article_incontent_mediumrect_mobile_02> </div> </div> </div> </section><p><span style="background-color:transparent;">But the malaria resistance is seemingly enough for evolution to bear the risk, especially because sickle cell is far more likely in populations with high malaria risk, like African populations.</span></p> </article><article id=entry-4 class="entry entry-article"><h2 class="subheading subheading-num"><label>2 </label><span>Short Sleepers </span></h2><figure class=image><img class=lozad data-src="https://s3.crackedcdn.com/phpimages/article/3/0/4/1198304.jpg" data-media-id=1198304 width=1000 height=667><figure class=ck-img-attr><figcaption><p>Shutterstock</p></figcaption></figure></figure><p><span style="background-color:transparent;">A mutation that</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">s come more into the spotlight recently because </span><a target=_blank rel=noopener href="https://www.cracked.com/article_44460_heres-what-a-five-hour-grindset-sleep-schedule-does-to-your-brain.html"><span style="background-color:transparent;">every grindset influencer worth their salt</span></a><span style="background-color:transparent;"> thinks they have it is one that produces what are known as “short sleepers.” The usual adult human needs seven to nine hours of sleep a night to operate at peak performance. Sure, you can squeeze in a couple short nights here and there, but it</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">ll have effects on your cognitive function. Unless you</span><span style="background-color:transparent;color:#000000;">’</span><span style="background-color:transparent;">re a bona fide, medically acknowledged “short sleeper,” people who seem to not only survive but thrive on </span><a target=_blank rel=noopener href="https://www.cnn.com/2021/06/22/health/short-sleep-gene-wellness-scn/index.html"><span style="background-color:transparent;">only five hours of sleep a night.</span></a><span style="background-color:transparent;"> </span></p><section class="ad-wrapper ad-mobile ad-injected-mobile"> <div class=ad-inner-wrapper> <label>Advertisement</label> <div class="ad ad-300x250 ad-code"> <div id=crd_article_incontent_mediumrect_mobile_03> </div> </div> </div> </section><p><span style="background-color:transparent;">Imagine what you could do with all that extra time! You could watch so many more videos of cows getting their hooves cleaned on YouTube!</span></p><section class="ad-wrapper ad-desktop"> <div class=ad-inner-wrapper> <label>Advertisement</label> <div class="ad ad-300x250m728x90 inject-desktop-ad"> <div id=crd_article_incontent_leaderboard_desktop_02 class=ad-code> </div> </div> </div> </section> </article><article id=entry-5 class="entry entry-article"><h2 class="subheading subheading-num"><label>1 </label><span>Holding Your Breath </span></h2><figure class=image><img class=lozad data-src="https://s3.crackedcdn.com/phpimages/article/3/0/5/1198305.jpg" data-media-id=1198305 width=1000 height=703><figure class=ck-img-attr><figcaption><p>Shutterstock</p></figcaption></figure></figure><p>More on the scale of David Blaine than Aquaman, but some people are designed to be able to hold their breath longer underwater than most. Specifically, the Bajau Laut population in Southeast Asia. It<span style="background-color:transparent;color:#000000;">’</span>s a mutation of necessity, seeing as their culture revolves around fishing, and they spend a remarkable amount of their lives underwater. </p><section class="ad-wrapper ad-mobile ad-injected-mobile"> <div class=ad-inner-wrapper> <label>Advertisement</label> <div class="ad ad-300x250 ad-code"> <div id=crd_article_incontent_mediumrect_mobile_04> </div> </div> </div> </section><p>When trying to see exactly what it is that makes them such consistently skilled divers, <a target=_blank rel=noopener href="https://www.sciencealert.com/indonesian-bajau-genetic-changes-adapt-them-to-aquatic-lifestyle-2">scientists found enlarged spleens and a variety of mutations affecting oxygen and carbon dioxide levels in blood</a>. Given that the spleen is known better for comedy than its actual function, I<span style="background-color:transparent;color:#000000;">’</span>ll elaborate: a larger spleen can store more red blood cells, allowing the owner to carry more oxygen down with them from the surface.</p> </article></article> <div class=outstream-mobile-wrapper></div> <nav class=socials> <a href="http://www.facebook.com/sharer/sharer.php?u=https://www.cracked.com/article_44615_5-useful-mutations-some-lucky-humans-have.html" class=facebook target=_blank rel=noopener title="5 Useful Mutations Some Lucky Humans Have"> <svg xmlns="http://www.w3.org/2000/svg" width=18 height=18 viewbox="0 0 24 24"><path d="M9 8h-3v4h3v12h5v-12h3.642l.358-4h-4v-1.667c0-.955.192-1.333 1.115-1.333h2.885v-5h-3.808c-3.596 0-5.192 1.583-5.192 4.615v3.385z"/></svg> <span>Facebook</span> </a> <a class=twitter href="https://twitter.com/share?url=https://www.cracked.com/article_44615_5-useful-mutations-some-lucky-humans-have.html&text=5 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