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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78747867/INDACO_project_COPD_and_link_between_comorbidities_lung_function_and_inhalation_therapy"><img alt="Research paper thumbnail of INDACO project: COPD and link between comorbidities, lung function and inhalation therapy" class="work-thumbnail" src="https://attachments.academia-assets.com/85685142/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78747867/INDACO_project_COPD_and_link_between_comorbidities_lung_function_and_inhalation_therapy">INDACO project: COPD and link between comorbidities, lung function and inhalation therapy</a></div><div class="wp-workCard_item"><span>Multidisciplinary Respiratory Medicine</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4a398851228af8ce8a3f99c011682f69" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85685142,"asset_id":78747867,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85685142/download_file?st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78747867"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div 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{"id":78747867,"title":"INDACO project: COPD and link between comorbidities, lung function and inhalation therapy","translated_title":"","metadata":{"publisher":"PAGEPress Publications","grobid_abstract":"Background: Chronic Obstructive Pulmonary Disease (COPD) is characterized by respiratory and extrarespiratory components referring both to systemic complications of COPD, like skeletal muscle myopathy, weight loss and others, and frequently associated comorbidities, interesting various organs and systems (cardiovascular diseases, malignancies, osteoporosis, diabetes, etc.). These comorbidities may increase the rate of hospitalization of COPD patients and have a huge effect on the outcomes of the respiratory disease. Inhalation therapy of COPD with bronchodilators and steroid is primary driven by airflow obstruction, symptoms like dyspnoea, and acute exacerbations. INDACO project has been developed in 2013 to assess the prevalence and type of comorbidities in COPD patients referred to the outpatient wards of some hospitals in Central and South Italy and a preliminary report has recently been published. In the present study, after widening that database, we evaluate the prevalence of comorbidities and the relationships between comorbidities and sex, age, symptoms, lung function and inhalation therapy in COPD patients. Methods: In each enrolled patient, anthropometric and anamnestic data, smoking habits, respiratory function, GOLD (Global initiative for Chronic Obstructive Lung Disease) severity stage, Body Mass Index (BMI), number of acute COPD exacerbations in previous years, presence and type of comorbidities, and the Charlson Comorbidity Index (CCI) were recorded. Results: We collected data of 569 patients (395 males and 174 females, mean age 73 ± 8.5 yrs). The prevalence of patients with comorbidities was 81.2%. Overall number of comorbidities was not related to airflow obstruction and age, but to acute exacerbation of COPD, dyspnoea measured with MRC scale, and male gender. A subgroup analysis revealed that ischaemic heart disease was predominant in males, whereas mood disorders in females. The use of a more complex (multi-drug) inhalation therapy was related with bronchial obstruction measured by FEV 1 /FVC (p for trend = 0.003) and number of comorbidities (p for trend = 0.001). In multivariate analysis, only airflow obstruction and number of comorbidities were determinant of complexity of therapy, but not MRC and acute exacerbation of COPD. However, the statistical model reached an extreme low degree of significance (r^2 = 0.07). Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Multidisciplinary Respiratory Medicine","grobid_abstract_attachment_id":85685142},"translated_abstract":null,"internal_url":"https://www.academia.edu/78747867/INDACO_project_COPD_and_link_between_comorbidities_lung_function_and_inhalation_therapy","translated_internal_url":"","created_at":"2022-05-08T05:45:22.232-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":85685142,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/85685142/thumbnails/1.jpg","file_name":"2049-6958-10-4.pdf","download_url":"https://www.academia.edu/attachments/85685142/download_file?st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"INDACO_project_COPD_and_link_between_com.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/85685142/2049-6958-10-4-libre.pdf?1652015139=\u0026response-content-disposition=attachment%3B+filename%3DINDACO_project_COPD_and_link_between_com.pdf\u0026Expires=1732704095\u0026Signature=UdEfang3-fJliHnLg-qCTZI39rg2BAuHvVxGwS0KLoIEyRBnet2AgqMvdmrJFqIAvi6HvQw50dxt~LVGbExhXF5PGw0-PYMmq8laSK8kwEQzUoQTCtt6Y3aycW2j55yPKFvMsk~UBUf7b97iqOW3j6idN74ApMY6Y47khylFwPJLDF2o6AJUVKPM7WoeaUlzRp08HiWh4LqN39nUdPa1w8148OCdeCFkxWomlTGYo-bLxZQEIm9rur01U1NT0C~TD0eOgqPuCvikfHyiE0aTUA1A4-Fr2hy-OOBxh61q9ne4r~Q0iZoOG1dE7vvcSem3T0Gma4IuHMXXsS9tkIgZtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"INDACO_project_COPD_and_link_between_comorbidities_lung_function_and_inhalation_therapy","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[{"id":85685142,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/85685142/thumbnails/1.jpg","file_name":"2049-6958-10-4.pdf","download_url":"https://www.academia.edu/attachments/85685142/download_file?st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"INDACO_project_COPD_and_link_between_com.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/85685142/2049-6958-10-4-libre.pdf?1652015139=\u0026response-content-disposition=attachment%3B+filename%3DINDACO_project_COPD_and_link_between_com.pdf\u0026Expires=1732704095\u0026Signature=UdEfang3-fJliHnLg-qCTZI39rg2BAuHvVxGwS0KLoIEyRBnet2AgqMvdmrJFqIAvi6HvQw50dxt~LVGbExhXF5PGw0-PYMmq8laSK8kwEQzUoQTCtt6Y3aycW2j55yPKFvMsk~UBUf7b97iqOW3j6idN74ApMY6Y47khylFwPJLDF2o6AJUVKPM7WoeaUlzRp08HiWh4LqN39nUdPa1w8148OCdeCFkxWomlTGYo-bLxZQEIm9rur01U1NT0C~TD0eOgqPuCvikfHyiE0aTUA1A4-Fr2hy-OOBxh61q9ne4r~Q0iZoOG1dE7vvcSem3T0Gma4IuHMXXsS9tkIgZtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[{"id":20321567,"url":"http://link.springer.com/content/pdf/10.1186/2049-6958-10-4.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78747865"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78747865/Cognitive_Impairment_in_Convalescent_COVID_19_Patients_Undergoing_Multidisciplinary_Rehabilitation_The_Association_with_the_Clinical_and_Functional_Status"><img alt="Research paper thumbnail of Cognitive Impairment in Convalescent COVID-19 Patients Undergoing Multidisciplinary Rehabilitation: The Association with the Clinical and Functional Status" class="work-thumbnail" src="https://attachments.academia-assets.com/85685134/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78747865/Cognitive_Impairment_in_Convalescent_COVID_19_Patients_Undergoing_Multidisciplinary_Rehabilitation_The_Association_with_the_Clinical_and_Functional_Status">Cognitive Impairment in Convalescent COVID-19 Patients Undergoing Multidisciplinary Rehabilitation: The Association with the Clinical and Functional Status</a></div><div class="wp-workCard_item"><span>Healthcare</span><span>, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) infection. We investigated the possible association between cognitive impairment and the main clinical and functional status variables in a cohort of convalescent COVID-19 patients without premorbid diseases potentially affecting cognition. Methods. We consecutively screened for inclusion of convalescent COVID-19 patients referring to a post-acute care facility for pulmonary rehabilitation. All the enrolled patients were assessed for cognitive functions. We also investigated features of psychological distress (anxiety, depression, symptoms of posttraumatic stress disorder and quality of life) and cardiac and pulmonary functional status. Results. The 63 enrolled patients (mean age 59.82 ± 10.78, male gender = 47) showed a high frequency of depressive symptoms (76.2%) and anxiety (55.5%), and a high prevalence of symptoms of posttraumatic stress di...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="21d9c7085f06e34f945964a1e1a88edb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85685134,"asset_id":78747865,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85685134/download_file?st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78747865"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78747865"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78747865; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78747865]").text(description); $(".js-view-count[data-work-id=78747865]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78747865; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78747865']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78747865, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "21d9c7085f06e34f945964a1e1a88edb" } } $('.js-work-strip[data-work-id=78747865]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78747865,"title":"Cognitive Impairment in Convalescent COVID-19 Patients Undergoing Multidisciplinary Rehabilitation: The Association with the Clinical and Functional Status","translated_title":"","metadata":{"abstract":"Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) infection. We investigated the possible association between cognitive impairment and the main clinical and functional status variables in a cohort of convalescent COVID-19 patients without premorbid diseases potentially affecting cognition. Methods. We consecutively screened for inclusion of convalescent COVID-19 patients referring to a post-acute care facility for pulmonary rehabilitation. All the enrolled patients were assessed for cognitive functions. We also investigated features of psychological distress (anxiety, depression, symptoms of posttraumatic stress disorder and quality of life) and cardiac and pulmonary functional status. Results. The 63 enrolled patients (mean age 59.82 ± 10.78, male gender = 47) showed a high frequency of depressive symptoms (76.2%) and anxiety (55.5%), and a high prevalence of symptoms of posttraumatic stress di...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2022,"errors":{}},"publication_name":"Healthcare"},"translated_abstract":"Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) infection. We investigated the possible association between cognitive impairment and the main clinical and functional status variables in a cohort of convalescent COVID-19 patients without premorbid diseases potentially affecting cognition. Methods. We consecutively screened for inclusion of convalescent COVID-19 patients referring to a post-acute care facility for pulmonary rehabilitation. All the enrolled patients were assessed for cognitive functions. We also investigated features of psychological distress (anxiety, depression, symptoms of posttraumatic stress disorder and quality of life) and cardiac and pulmonary functional status. Results. 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Therefore, a single strategy of pulmonary rehabilitation (PR) does not always yield the expected clinical outcomes as some individuals respond excellently, others discreetly, or do not respond at all. Fifty consecutive COPD patients were enrolled. Of them, 35 starting a 5-week PR program were sampled at admission (T0), after 2 (T2W) and 5 (T5W) weeks, while 15 controls not yet on PR were tested at T0 and T5W. Nuclear magnetic resonance (NMR) profiling of exhaled breath condensate (EBC) and multivariate statistical analysis were applied to investigate the relationship between biomarkers and clinical parameters. The model including the three classes correctly located T2W between T0 and T5W, but 38.71% of samples partially overlapped with T0 and 32.26% with T5W, suggesting that for some patients PR is already beneficial at T2W (32.26% overlapping with T5W), while for others...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9aa5b92bf4707c18ec8cf2472764397d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81411911,"asset_id":72514189,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81411911/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514189; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514189]").text(description); $(".js-view-count[data-work-id=72514189]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514189; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514189']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514189, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9aa5b92bf4707c18ec8cf2472764397d" } } $('.js-work-strip[data-work-id=72514189]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514189,"title":"Metabolomics of COPD Pulmonary Rehabilitation Outcomes via Exhaled Breath Condensate","translated_title":"","metadata":{"abstract":"Chronic obstructive pulmonary disease (COPD) is characterized by different phenotypes and clinical presentations. Therefore, a single strategy of pulmonary rehabilitation (PR) does not always yield the expected clinical outcomes as some individuals respond excellently, others discreetly, or do not respond at all. Fifty consecutive COPD patients were enrolled. Of them, 35 starting a 5-week PR program were sampled at admission (T0), after 2 (T2W) and 5 (T5W) weeks, while 15 controls not yet on PR were tested at T0 and T5W. Nuclear magnetic resonance (NMR) profiling of exhaled breath condensate (EBC) and multivariate statistical analysis were applied to investigate the relationship between biomarkers and clinical parameters. The model including the three classes correctly located T2W between T0 and T5W, but 38.71% of samples partially overlapped with T0 and 32.26% with T5W, suggesting that for some patients PR is already beneficial at T2W (32.26% overlapping with T5W), while for others...","publisher":"MDPI AG","publication_name":"Cells"},"translated_abstract":"Chronic obstructive pulmonary disease (COPD) is characterized by different phenotypes and clinical presentations. Therefore, a single strategy of pulmonary rehabilitation (PR) does not always yield the expected clinical outcomes as some individuals respond excellently, others discreetly, or do not respond at all. Fifty consecutive COPD patients were enrolled. Of them, 35 starting a 5-week PR program were sampled at admission (T0), after 2 (T2W) and 5 (T5W) weeks, while 15 controls not yet on PR were tested at T0 and T5W. Nuclear magnetic resonance (NMR) profiling of exhaled breath condensate (EBC) and multivariate statistical analysis were applied to investigate the relationship between biomarkers and clinical parameters. The model including the three classes correctly located T2W between T0 and T5W, but 38.71% of samples partially overlapped with T0 and 32.26% with T5W, suggesting that for some patients PR is already beneficial at T2W (32.26% overlapping with T5W), while for others...","internal_url":"https://www.academia.edu/72514189/Metabolomics_of_COPD_Pulmonary_Rehabilitation_Outcomes_via_Exhaled_Breath_Condensate","translated_internal_url":"","created_at":"2022-02-26T13:34:38.278-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81411911,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411911/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/81411911/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Metabolomics_of_COPD_Pulmonary_Rehabilit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411911/pdf-libre.pdf?1645911611=\u0026response-content-disposition=attachment%3B+filename%3DMetabolomics_of_COPD_Pulmonary_Rehabilit.pdf\u0026Expires=1732704096\u0026Signature=dQfnWVY6XgkAsAbCtBVerS3h-2zXpFFvMZBHmscqPkELlsqYUXbTuKQsEBMdKsnkh~F9MSA5h6ZXBtfGCZkeP9NqpDySjU-ICAuaBosZI4mwdY02Pw~UKliq7I6qFjhfq3WJGJfNM8vutUfxFqxwEVFsXxVN74Fs0oUmzi0Q8hXQU9P~Gaeg5uV9AaRkzejhvuI1HyF8L33Cg9vfjqGlFoTc78VYQx6Q~U-ybQg4Zkyk72G-thhL2abIpi22IwwE~UAzAr5BYKZoLb1fp88N9pBwjaXqN~9ydhXS6jW6Xpo3VFEKklQQrRzkuiT1tHIQWy78fX4f-1vBEZQzGXLUiw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Metabolomics_of_COPD_Pulmonary_Rehabilitation_Outcomes_via_Exhaled_Breath_Condensate","translated_slug":"","page_count":17,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[{"id":81411911,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411911/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/81411911/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Metabolomics_of_COPD_Pulmonary_Rehabilit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411911/pdf-libre.pdf?1645911611=\u0026response-content-disposition=attachment%3B+filename%3DMetabolomics_of_COPD_Pulmonary_Rehabilit.pdf\u0026Expires=1732704096\u0026Signature=dQfnWVY6XgkAsAbCtBVerS3h-2zXpFFvMZBHmscqPkELlsqYUXbTuKQsEBMdKsnkh~F9MSA5h6ZXBtfGCZkeP9NqpDySjU-ICAuaBosZI4mwdY02Pw~UKliq7I6qFjhfq3WJGJfNM8vutUfxFqxwEVFsXxVN74Fs0oUmzi0Q8hXQU9P~Gaeg5uV9AaRkzejhvuI1HyF8L33Cg9vfjqGlFoTc78VYQx6Q~U-ybQg4Zkyk72G-thhL2abIpi22IwwE~UAzAr5BYKZoLb1fp88N9pBwjaXqN~9ydhXS6jW6Xpo3VFEKklQQrRzkuiT1tHIQWy78fX4f-1vBEZQzGXLUiw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":81411912,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411912/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/81411912/download_file","bulk_download_file_name":"Metabolomics_of_COPD_Pulmonary_Rehabilit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411912/pdf-libre.pdf?1645911612=\u0026response-content-disposition=attachment%3B+filename%3DMetabolomics_of_COPD_Pulmonary_Rehabilit.pdf\u0026Expires=1732704096\u0026Signature=Tri~7n9HWkaZUjyNAehbFslAOUe1e3mWqv7ZrARyMemFUezrybBB4The50Pv0pKdyl5sIxPiex4avHD1eC1d3Nlo~aWLx6xyx-By1imlk1Bm7O01plKWUCaovI~4Z-li20ibI56tT0ePSRjr2Qo1WF83jY6XlLeLW3tRGJy5Wx~lVCA1ykYVA9yfgAUqRoj5pjkh~zKiRbnql-n3t4-Nw7GJN6OmB1mmeqWaEGRZdwUgnKNkaqzroS36VW7nqopNd3hsntIPq-2lY602z3ivrTkorp8DKnd0uX-HdhxU-H4dUnVmvS3Is5PoDX38Mn~wCL7p9iryiBYKD-8skDVlqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":325749,"name":"Cells","url":"https://www.academia.edu/Documents/in/Cells"}],"urls":[{"id":18048871,"url":"https://www.mdpi.com/2073-4409/11/3/344/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514188"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514188/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease"><img alt="Research paper thumbnail of Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease" class="work-thumbnail" src="https://attachments.academia-assets.com/81411910/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514188/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease">Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease</a></div><div class="wp-workCard_item"><span>Respiratory care</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="25bd51426c7ef6a329c061fd923e30e4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81411910,"asset_id":72514188,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81411910/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514188; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514188]").text(description); $(".js-view-count[data-work-id=72514188]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514188; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514188']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514188, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "25bd51426c7ef6a329c061fd923e30e4" } } $('.js-work-strip[data-work-id=72514188]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514188,"title":"Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease","translated_title":"","metadata":{"abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Respiratory care"},"translated_abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.","internal_url":"https://www.academia.edu/72514188/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease","translated_internal_url":"","created_at":"2022-02-26T13:34:38.124-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81411910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411910/thumbnails/1.jpg","file_name":"08.10.1091.pdf","download_url":"https://www.academia.edu/attachments/81411910/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Severe_respiratory_and_skeletal_muscles.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411910/08.10.1091-libre.pdf?1645911608=\u0026response-content-disposition=attachment%3B+filename%3DSevere_respiratory_and_skeletal_muscles.pdf\u0026Expires=1732704096\u0026Signature=RjHLKVofH9L29wwjAS9LYIOnhIO6SYIuuf4bsg4KNe59pP4~~eqzFsIgx8ofYKvMkd7Rx3DbnERILNr416PxjTYgPKwVAevumRsskCiaoEQn27viDqyWKL-I6CzaVOGUvlvxyZ7sT7JjksttAGKrUr-GZdLO0D3BHB6Uu3Xp6KYtQIGyMQ0uRLYCZtZZTMo1cOies9d8ULmRe1-548y~devAzKIAgU3JxHhGMpVuiuKjT-8fcXV4Ze7vfi4guhoSRkDRNdtKmKoWh9Kz2I1Ljq9YsGVk-F8v9YB5-zbo-0r9trUB14JtlDgNyWvdGfDm5eyHtgDJvRhFjWd8I78aGQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[{"id":81411910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411910/thumbnails/1.jpg","file_name":"08.10.1091.pdf","download_url":"https://www.academia.edu/attachments/81411910/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Severe_respiratory_and_skeletal_muscles.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411910/08.10.1091-libre.pdf?1645911608=\u0026response-content-disposition=attachment%3B+filename%3DSevere_respiratory_and_skeletal_muscles.pdf\u0026Expires=1732704096\u0026Signature=RjHLKVofH9L29wwjAS9LYIOnhIO6SYIuuf4bsg4KNe59pP4~~eqzFsIgx8ofYKvMkd7Rx3DbnERILNr416PxjTYgPKwVAevumRsskCiaoEQn27viDqyWKL-I6CzaVOGUvlvxyZ7sT7JjksttAGKrUr-GZdLO0D3BHB6Uu3Xp6KYtQIGyMQ0uRLYCZtZZTMo1cOies9d8ULmRe1-548y~devAzKIAgU3JxHhGMpVuiuKjT-8fcXV4Ze7vfi4guhoSRkDRNdtKmKoWh9Kz2I1Ljq9YsGVk-F8v9YB5-zbo-0r9trUB14JtlDgNyWvdGfDm5eyHtgDJvRhFjWd8I78aGQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":11298,"name":"Membrane Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins"},{"id":98995,"name":"Muscular Dystrophies","url":"https://www.academia.edu/Documents/in/Muscular_Dystrophies"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":309137,"name":"Respiratory Muscles","url":"https://www.academia.edu/Documents/in/Respiratory_Muscles"},{"id":556576,"name":"Chronic obstructive pulmonary disease","url":"https://www.academia.edu/Documents/in/Chronic_obstructive_pulmonary_disease"},{"id":876966,"name":"Blood gas analysis","url":"https://www.academia.edu/Documents/in/Blood_gas_analysis"},{"id":1640066,"name":"Respiratory Care","url":"https://www.academia.edu/Documents/in/Respiratory_Care"},{"id":3063336,"name":"Respiratory function tests","url":"https://www.academia.edu/Documents/in/Respiratory_function_tests"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":18048870,"url":"https://air.unimi.it/retrieve/handle/2434/149591/153427/08.10.1091.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514187"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514187/Therapy"><img alt="Research paper thumbnail of Therapy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514187/Therapy">Therapy</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Full list of author information is available at the end of the articlenumber of comorbidities wer...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Full list of author information is available at the end of the articlenumber of comorbidities were determinant of complexity of therapy, but not MRC and acute exacerbation of COPD. However, the statistical model reached an extreme low degree of significance (r^2 = 0.07). Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514187"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514187"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514187; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514187]").text(description); $(".js-view-count[data-work-id=72514187]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514187; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514187']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514187, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72514187]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514187,"title":"Therapy","translated_title":"","metadata":{"abstract":"Full list of author information is available at the end of the articlenumber of comorbidities were determinant of complexity of therapy, but not MRC and acute exacerbation of COPD. However, the statistical model reached an extreme low degree of significance (r^2 = 0.07). Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}}},"translated_abstract":"Full list of author information is available at the end of the articlenumber of comorbidities were determinant of complexity of therapy, but not MRC and acute exacerbation of COPD. However, the statistical model reached an extreme low degree of significance (r^2 = 0.07). Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.","internal_url":"https://www.academia.edu/72514187/Therapy","translated_internal_url":"","created_at":"2022-02-26T13:34:37.962-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Therapy","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":65341,"name":"COPD","url":"https://www.academia.edu/Documents/in/COPD"},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking"},{"id":135852,"name":"BMI","url":"https://www.academia.edu/Documents/in/BMI"},{"id":1383212,"name":"Comorbidities","url":"https://www.academia.edu/Documents/in/Comorbidities"}],"urls":[{"id":18048869,"url":"http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.812.3013\u0026rep=rep1\u0026type=pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514186"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514186/Metabolomics_approach_applied_to_exhaled_breath_condensate_in_lung_cancer"><img alt="Research paper thumbnail of Metabolomics approach applied to exhaled breath condensate in lung cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514186/Metabolomics_approach_applied_to_exhaled_breath_condensate_in_lung_cancer">Metabolomics approach applied to exhaled breath condensate in lung cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several studies on lung cancer research have been performed with the aim of revealing biomarkers ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several studies on lung cancer research have been performed with the aim of revealing biomarkers representative of the cancer phenotype as well as possible therapeutic targets. This has led to the identification of many molecular features involved in lung cancer with new biochemical adaptations in the carcinogenetic process with quantitative changes in endogenous metabolites [1]. Recently, omics sciences have arising interest in cancer research as they could potentially detect new biomarkers, improving disease diagnosis and evaluating the effect of the treatment [2]. Among all omics, metabolomics is currently, one of the fastest developing disciplines in cancer research. In fact, metabolomics is the comprehensive assessment of endogenous metabolites (metabolome) and attempts to systematically identify and quantify metabolites from a biological specimen in a both global and targeted manner [3, 4]. 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This has led to the identification of many molecular features involved in lung cancer with new biochemical adaptations in the carcinogenetic process with quantitative changes in endogenous metabolites [1]. Recently, omics sciences have arising interest in cancer research as they could potentially detect new biomarkers, improving disease diagnosis and evaluating the effect of the treatment [2]. Among all omics, metabolomics is currently, one of the fastest developing disciplines in cancer research. In fact, metabolomics is the comprehensive assessment of endogenous metabolites (metabolome) and attempts to systematically identify and quantify metabolites from a biological specimen in a both global and targeted manner [3, 4]. The application of metabolomics to cancer is increasing year by year in the search for ...","publication_date":{"day":null,"month":null,"year":2017,"errors":{}}},"translated_abstract":"Several studies on lung cancer research have been performed with the aim of revealing biomarkers representative of the cancer phenotype as well as possible therapeutic targets. This has led to the identification of many molecular features involved in lung cancer with new biochemical adaptations in the carcinogenetic process with quantitative changes in endogenous metabolites [1]. Recently, omics sciences have arising interest in cancer research as they could potentially detect new biomarkers, improving disease diagnosis and evaluating the effect of the treatment [2]. Among all omics, metabolomics is currently, one of the fastest developing disciplines in cancer research. In fact, metabolomics is the comprehensive assessment of endogenous metabolites (metabolome) and attempts to systematically identify and quantify metabolites from a biological specimen in a both global and targeted manner [3, 4]. The application of metabolomics to cancer is increasing year by year in the search for ...","internal_url":"https://www.academia.edu/72514186/Metabolomics_approach_applied_to_exhaled_breath_condensate_in_lung_cancer","translated_internal_url":"","created_at":"2022-02-26T13:34:37.821-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Metabolomics_approach_applied_to_exhaled_breath_condensate_in_lung_cancer","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514180"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514180/Case_Reports_Severe_Respiratory_and_Skeletal_Muscles_Involvement_in_a_Carrier_of_Dysferlinopathy_With_Chronic_Obstructive_Pulmonary_Disease"><img alt="Research paper thumbnail of Case Reports Severe Respiratory and Skeletal Muscles Involvement in a Carrier of Dysferlinopathy With Chronic Obstructive Pulmonary Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/81411943/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514180/Case_Reports_Severe_Respiratory_and_Skeletal_Muscles_Involvement_in_a_Carrier_of_Dysferlinopathy_With_Chronic_Obstructive_Pulmonary_Disease">Case Reports Severe Respiratory and Skeletal Muscles Involvement in a Carrier of Dysferlinopathy With Chronic Obstructive Pulmonary Disease</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The natural course of progressive neuromuscular diseases can be complicated by respiratory mus-cl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The natural course of progressive neuromuscular diseases can be complicated by respiratory mus-cle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally oc-curs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment. Key words: chronic obstructive pulmonary disease; respirator...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="531bc4dfa8a8b8ab3be42759f9c6ddd2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81411943,"asset_id":72514180,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81411943/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514180"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514180"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514180; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514180]").text(description); $(".js-view-count[data-work-id=72514180]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514180; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514180']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514180, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "531bc4dfa8a8b8ab3be42759f9c6ddd2" } } $('.js-work-strip[data-work-id=72514180]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514180,"title":"Case Reports Severe Respiratory and Skeletal Muscles Involvement in a Carrier of Dysferlinopathy With Chronic Obstructive Pulmonary Disease","translated_title":"","metadata":{"abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory mus-cle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally oc-curs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment. Key words: chronic obstructive pulmonary disease; respirator...","publication_date":{"day":null,"month":null,"year":2016,"errors":{}}},"translated_abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory mus-cle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally oc-curs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment. Key words: chronic obstructive pulmonary disease; respirator...","internal_url":"https://www.academia.edu/72514180/Case_Reports_Severe_Respiratory_and_Skeletal_Muscles_Involvement_in_a_Carrier_of_Dysferlinopathy_With_Chronic_Obstructive_Pulmonary_Disease","translated_internal_url":"","created_at":"2022-02-26T13:34:10.058-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81411943,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411943/thumbnails/1.jpg","file_name":"1091.full.pdf","download_url":"https://www.academia.edu/attachments/81411943/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Reports_Severe_Respiratory_and_Skel.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411943/1091.full-libre.pdf?1645911606=\u0026response-content-disposition=attachment%3B+filename%3DCase_Reports_Severe_Respiratory_and_Skel.pdf\u0026Expires=1732704096\u0026Signature=buPkZS7Wsclrwe-pdDXTileN1NnDoPQsM4F~UY272T~iGYruSPLyZnNUYgUQJ4GB726CaEUbf6JZuBZNRM5kR29P43lVgT6YkzT1Xvgm7SlTo7O8jWqhMv~ONAa-IFCBOd0YnHMhyI5XX7I2RtfdcRPqrg454Mffbvsokyv91EPaWTHfqpJ5~6dFmGApb4KOn~X~DtsGn4dduEjBZFVJAbt-p6jyVPO8vBM8W2KnApQ73glZj28Etz420fZVKPJ0PijRfTvir3qdtROmMuSWAtFgGRDaY5d6RPwgUws2sSOaW1A5Iwm5MjwFklwAJpUJHBC1YQ7Zh8yyW~jzQSo-Lw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Case_Reports_Severe_Respiratory_and_Skeletal_Muscles_Involvement_in_a_Carrier_of_Dysferlinopathy_With_Chronic_Obstructive_Pulmonary_Disease","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[{"id":81411943,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411943/thumbnails/1.jpg","file_name":"1091.full.pdf","download_url":"https://www.academia.edu/attachments/81411943/download_file?st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Reports_Severe_Respiratory_and_Skel.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411943/1091.full-libre.pdf?1645911606=\u0026response-content-disposition=attachment%3B+filename%3DCase_Reports_Severe_Respiratory_and_Skel.pdf\u0026Expires=1732704096\u0026Signature=buPkZS7Wsclrwe-pdDXTileN1NnDoPQsM4F~UY272T~iGYruSPLyZnNUYgUQJ4GB726CaEUbf6JZuBZNRM5kR29P43lVgT6YkzT1Xvgm7SlTo7O8jWqhMv~ONAa-IFCBOd0YnHMhyI5XX7I2RtfdcRPqrg454Mffbvsokyv91EPaWTHfqpJ5~6dFmGApb4KOn~X~DtsGn4dduEjBZFVJAbt-p6jyVPO8vBM8W2KnApQ73glZj28Etz420fZVKPJ0PijRfTvir3qdtROmMuSWAtFgGRDaY5d6RPwgUws2sSOaW1A5Iwm5MjwFklwAJpUJHBC1YQ7Zh8yyW~jzQSo-Lw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":18048865,"url":"http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.989.4353\u0026rep=rep1\u0026type=pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513838"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513838/Portable_oxygen_concentrator_vesus_oxygen_cylinder_in_chronic_lung_disease_patient_preferences_and_psychological_implications"><img alt="Research paper thumbnail of Portable oxygen concentrator vesus oxygen cylinder in chronic lung disease: patient preferences and psychological implications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513838/Portable_oxygen_concentrator_vesus_oxygen_cylinder_in_chronic_lung_disease_patient_preferences_and_psychological_implications">Portable oxygen concentrator vesus oxygen cylinder in chronic lung disease: patient preferences and psychological implications</a></div><div class="wp-workCard_item"><span>European Respiratory Journal</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513838"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513838"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513838; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513836"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513836/A_Rapid_Antigen_Detection_Test_to_Diagnose_SARS_CoV_2_Infection_Using_Exhaled_Breath_Condensate_by_A_Modified_Inflammacheck_Device"><img alt="Research paper thumbnail of A Rapid Antigen Detection Test to Diagnose SARS-CoV-2 Infection Using Exhaled Breath Condensate by A Modified Inflammacheck® Device" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513836/A_Rapid_Antigen_Detection_Test_to_Diagnose_SARS_CoV_2_Infection_Using_Exhaled_Breath_Condensate_by_A_Modified_Inflammacheck_Device">A Rapid Antigen Detection Test to Diagnose SARS-CoV-2 Infection Using Exhaled Breath Condensate by A Modified Inflammacheck® Device</a></div><div class="wp-workCard_item"><span>Sensors (Basel, Switzerland)</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: The standard test that identifies the severe acute respiratory syndrome coronavirus-2...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: The standard test that identifies the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is based on reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal (NP) swab specimens. We compared the accuracy of a rapid antigen detection test using exhaled breath condensate by a modified Inflammacheck® device with the standard RT-PCR to diagnose SARS-CoV-2 infection. Methods: We performed a manufacturer-independent, cross-sectional, diagnostic accuracy study involving two Italian hospitals. Sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), positive (PPV) and negative predictive value (NPV) and diagnostic accuracy with 95% confidence intervals (95% CI) of Inflammacheck® were calculated using the RT-PCR results as the standard. Further RT-PCR tests were conducted on NP specimens from test positive subjects to obtain the Ct (cycle threshold) values as indicative evidence of the viral load. Results: A total of 105 individu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513836"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513836"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513836; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513836]").text(description); $(".js-view-count[data-work-id=65513836]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513836; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513836']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513836, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513836]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513836,"title":"A Rapid Antigen Detection Test to Diagnose SARS-CoV-2 Infection Using Exhaled Breath Condensate by A Modified Inflammacheck® Device","translated_title":"","metadata":{"abstract":"Background: The standard test that identifies the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is based on reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal (NP) swab specimens. We compared the accuracy of a rapid antigen detection test using exhaled breath condensate by a modified Inflammacheck® device with the standard RT-PCR to diagnose SARS-CoV-2 infection. Methods: We performed a manufacturer-independent, cross-sectional, diagnostic accuracy study involving two Italian hospitals. Sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), positive (PPV) and negative predictive value (NPV) and diagnostic accuracy with 95% confidence intervals (95% CI) of Inflammacheck® were calculated using the RT-PCR results as the standard. Further RT-PCR tests were conducted on NP specimens from test positive subjects to obtain the Ct (cycle threshold) values as indicative evidence of the viral load. Results: A total of 105 individu...","publisher":"Sensors","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Sensors (Basel, Switzerland)"},"translated_abstract":"Background: The standard test that identifies the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is based on reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal (NP) swab specimens. We compared the accuracy of a rapid antigen detection test using exhaled breath condensate by a modified Inflammacheck® device with the standard RT-PCR to diagnose SARS-CoV-2 infection. Methods: We performed a manufacturer-independent, cross-sectional, diagnostic accuracy study involving two Italian hospitals. Sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), positive (PPV) and negative predictive value (NPV) and diagnostic accuracy with 95% confidence intervals (95% CI) of Inflammacheck® were calculated using the RT-PCR results as the standard. Further RT-PCR tests were conducted on NP specimens from test positive subjects to obtain the Ct (cycle threshold) values as indicative evidence of the viral load. Results: A total of 105 individu...","internal_url":"https://www.academia.edu/65513836/A_Rapid_Antigen_Detection_Test_to_Diagnose_SARS_CoV_2_Infection_Using_Exhaled_Breath_Condensate_by_A_Modified_Inflammacheck_Device","translated_internal_url":"","created_at":"2021-12-22T07:42:43.640-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_Rapid_Antigen_Detection_Test_to_Diagnose_SARS_CoV_2_Infection_Using_Exhaled_Breath_Condensate_by_A_Modified_Inflammacheck_Device","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[{"id":15536794,"url":"https://doi.org/10.3390/s21175710"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513835"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513835/Long_term_Effects_of_Vasodilators_in_Combined_Pulmonary_Fibrosis_and_Emphysema_with_Severe_Pulmonary_Hypertension_A_Case_Report"><img alt="Research paper thumbnail of Long-term Effects of Vasodilators in Combined Pulmonary Fibrosis and Emphysema with Severe Pulmonary Hypertension: A Case Report" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513835/Long_term_Effects_of_Vasodilators_in_Combined_Pulmonary_Fibrosis_and_Emphysema_with_Severe_Pulmonary_Hypertension_A_Case_Report">Long-term Effects of Vasodilators in Combined Pulmonary Fibrosis and Emphysema with Severe Pulmonary Hypertension: A Case Report</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513835"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513835"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513835; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513835]").text(description); $(".js-view-count[data-work-id=65513835]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513835; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513835']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513835, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513835]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513835,"title":"Long-term Effects of Vasodilators in Combined Pulmonary Fibrosis and Emphysema with Severe Pulmonary Hypertension: A Case Report","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2018,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/65513835/Long_term_Effects_of_Vasodilators_in_Combined_Pulmonary_Fibrosis_and_Emphysema_with_Severe_Pulmonary_Hypertension_A_Case_Report","translated_internal_url":"","created_at":"2021-12-22T07:42:43.532-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Long_term_Effects_of_Vasodilators_in_Combined_Pulmonary_Fibrosis_and_Emphysema_with_Severe_Pulmonary_Hypertension_A_Case_Report","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513834"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513834/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease"><img alt="Research paper thumbnail of Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease" class="work-thumbnail" src="https://attachments.academia-assets.com/77076775/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513834/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease">Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="908ab157fa32febf55b589e1614ab935" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77076775,"asset_id":65513834,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77076775/download_file?st=MTczMjcwMDQ5Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513834"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513834"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513834; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513834]").text(description); $(".js-view-count[data-work-id=65513834]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513834; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513834']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513834, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "908ab157fa32febf55b589e1614ab935" } } $('.js-work-strip[data-work-id=65513834]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513834,"title":"Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease","translated_title":"","metadata":{"abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.","publisher":"Respiratory care","publication_date":{"day":null,"month":null,"year":2010,"errors":{}}},"translated_abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle 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medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":15536793,"url":"http://rc.rcjournal.com/content/respcare/55/8/1091.full.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513833"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513833/Subject_Preferences_and_Psychological_Implications_of_Portable_Oxygen_Concentrator_Versus_Compressed_Oxygen_Cylinder_in_Chronic_Lung_Disease"><img alt="Research paper thumbnail of Subject Preferences and Psychological Implications of Portable Oxygen Concentrator Versus Compressed Oxygen Cylinder in Chronic Lung Disease" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513833/Subject_Preferences_and_Psychological_Implications_of_Portable_Oxygen_Concentrator_Versus_Compressed_Oxygen_Cylinder_in_Chronic_Lung_Disease">Subject Preferences and Psychological Implications of Portable Oxygen Concentrator Versus Compressed Oxygen Cylinder in Chronic Lung Disease</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND: Oxygen therapy represents the elective therapy to improve the quality of life for pat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND: Oxygen therapy represents the elective therapy to improve the quality of life for patients with chronic respiratory diseases like COPD and interstitial lung disease. Lightweight portable oxygen concentrators (POCs) are a valid alternative to traditional systems such as portable compressed oxygen cylinders. However, patient preference and the possible psychological implications related to the use of both devices have been poorly assessed. We sought to evaluate patient preference between the ambulatory oxygen systems (ie, a POC or a small cylinder) for patients with COPD and interstitial lung disease experiencing exertional desaturation in a rehabilitation setting. Furthermore, the use of one device in comparison with the other was related to specific mechanical characteristics and related to perceived quality of life, anxiety, and depressive symptoms. METHODS: 30 subjects with COPD and interstitial lung disease, who demonstrated exertional desaturation on room air during ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513833"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513833"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513833; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513833]").text(description); $(".js-view-count[data-work-id=65513833]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513833; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513833']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513833, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513833]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513833,"title":"Subject Preferences and Psychological Implications of Portable Oxygen Concentrator Versus Compressed Oxygen Cylinder in Chronic Lung Disease","translated_title":"","metadata":{"abstract":"BACKGROUND: Oxygen therapy represents the elective therapy to improve the quality of life for patients with chronic respiratory diseases like COPD and interstitial lung disease. Lightweight portable oxygen concentrators (POCs) are a valid alternative to traditional systems such as portable compressed oxygen cylinders. However, patient preference and the possible psychological implications related to the use of both devices have been poorly assessed. We sought to evaluate patient preference between the ambulatory oxygen systems (ie, a POC or a small cylinder) for patients with COPD and interstitial lung disease experiencing exertional desaturation in a rehabilitation setting. Furthermore, the use of one device in comparison with the other was related to specific mechanical characteristics and related to perceived quality of life, anxiety, and depressive symptoms. METHODS: 30 subjects with COPD and interstitial lung disease, who demonstrated exertional desaturation on room air during ...","publisher":"Respiratory Care","publication_date":{"day":null,"month":null,"year":2020,"errors":{}}},"translated_abstract":"BACKGROUND: Oxygen therapy represents the elective therapy to improve the quality of life for patients with chronic respiratory diseases like COPD and interstitial lung disease. Lightweight portable oxygen concentrators (POCs) are a valid alternative to traditional systems such as portable compressed oxygen cylinders. However, patient preference and the possible psychological implications related to the use of both devices have been poorly assessed. We sought to evaluate patient preference between the ambulatory oxygen systems (ie, a POC or a small cylinder) for patients with COPD and interstitial lung disease experiencing exertional desaturation in a rehabilitation setting. Furthermore, the use of one device in comparison with the other was related to specific mechanical characteristics and related to perceived quality of life, anxiety, and depressive symptoms. METHODS: 30 subjects with COPD and interstitial lung disease, who demonstrated exertional desaturation on room air during ...","internal_url":"https://www.academia.edu/65513833/Subject_Preferences_and_Psychological_Implications_of_Portable_Oxygen_Concentrator_Versus_Compressed_Oxygen_Cylinder_in_Chronic_Lung_Disease","translated_internal_url":"","created_at":"2021-12-22T07:42:43.281-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Subject_Preferences_and_Psychological_Implications_of_Portable_Oxygen_Concentrator_Versus_Compressed_Oxygen_Cylinder_in_Chronic_Lung_Disease","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513832"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513832/Performance_of_fractional_exhaled_nitric_oxide_in_predicting_response_to_inhaled_corticosteroids_in_chronic_cough_a_meta_analysis"><img alt="Research paper thumbnail of Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513832/Performance_of_fractional_exhaled_nitric_oxide_in_predicting_response_to_inhaled_corticosteroids_in_chronic_cough_a_meta_analysis">Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis</a></div><div class="wp-workCard_item"><span>Annals of Medicine</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract Background. Chronic cough is a disabling condition with a high proportion of diagnostic ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract Background. Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) has been considered a useful biomarker for predicting inhaled corticosteroids (ICS) response. We evaluated the relationship between FeNO and ICS response in chronic cough by performing a systematic review with meta-analysis. Methods. PubMed, Web of Science, Scopus and EMBASE databases were systematically searched. Differences were expressed as Odds Ratio (OR) with 95% confidence intervals (95%CI). Pooled sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), and area under the hierarchical summary receiver operating characteristic curve (HSROCAUC) were estimated. Results. Nine articles on 740 chronic-cough patients showed that the response rate to ICS was 87.4% (95%CI: 83.8–91.0) in 317 patients with a high FeNO and 46.3% (95%CI: 41.6–51.0) in 423 controls, with an attributable proportion of 47.0% and a diagnostic OR of 9.1 (95%CI: 3.7–22.4, p &lt; .001). The pooled estimate of diagnostic indexes resulted in a sensitivity of 68.5% (95%CI: 46.7–84.4) and specificity of 81.9% (95%CI: 63.0–92.3), with a HSROCAUC of 0.82 (95%CI: 0.64–0.90). In a realistic scenario with a pre-test probability set at 30%, based on a pooled PLR of 3.79 (95%CI: 1.24–7.47) and NLR of 0.38 (95%CI: 0.22–0.66), the post-test probability was 62% with a high FeNO and 14% if the test was negative. Subgroup analyses confirmed a better performance for the recommended FeNO cut-off greater than 25 ppb. Meta-regression and sensitivity analyses showed no impact of major demographic and clinic variables on results. Conclusions. A high FeNO before starting ICS therapy may help identify chronic-cough patients responding to treatment, with a better performance ofhigher cut-off values. Further studies are needed to evaluate the real usefulness of this biomarker to guide cough therapy and optimise strategies in different healthcare settings (community, hospital, rehabilitation). Key messages Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) may be a useful biomarker for identifying chronic cough patients who respond to steroid treatment. A FeNO cut-off lower than 25 ppb should be considered irrelevant for this clinical application.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513832"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513832"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513832; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513832]").text(description); $(".js-view-count[data-work-id=65513832]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513832; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513832']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513832, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513832]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513832,"title":"Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis","translated_title":"","metadata":{"abstract":"Abstract Background. Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) has been considered a useful biomarker for predicting inhaled corticosteroids (ICS) response. We evaluated the relationship between FeNO and ICS response in chronic cough by performing a systematic review with meta-analysis. Methods. PubMed, Web of Science, Scopus and EMBASE databases were systematically searched. Differences were expressed as Odds Ratio (OR) with 95% confidence intervals (95%CI). Pooled sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), and area under the hierarchical summary receiver operating characteristic curve (HSROCAUC) were estimated. Results. Nine articles on 740 chronic-cough patients showed that the response rate to ICS was 87.4% (95%CI: 83.8–91.0) in 317 patients with a high FeNO and 46.3% (95%CI: 41.6–51.0) in 423 controls, with an attributable proportion of 47.0% and a diagnostic OR of 9.1 (95%CI: 3.7–22.4, p \u0026lt; .001). The pooled estimate of diagnostic indexes resulted in a sensitivity of 68.5% (95%CI: 46.7–84.4) and specificity of 81.9% (95%CI: 63.0–92.3), with a HSROCAUC of 0.82 (95%CI: 0.64–0.90). In a realistic scenario with a pre-test probability set at 30%, based on a pooled PLR of 3.79 (95%CI: 1.24–7.47) and NLR of 0.38 (95%CI: 0.22–0.66), the post-test probability was 62% with a high FeNO and 14% if the test was negative. Subgroup analyses confirmed a better performance for the recommended FeNO cut-off greater than 25 ppb. Meta-regression and sensitivity analyses showed no impact of major demographic and clinic variables on results. Conclusions. A high FeNO before starting ICS therapy may help identify chronic-cough patients responding to treatment, with a better performance ofhigher cut-off values. Further studies are needed to evaluate the real usefulness of this biomarker to guide cough therapy and optimise strategies in different healthcare settings (community, hospital, rehabilitation). Key messages Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) may be a useful biomarker for identifying chronic cough patients who respond to steroid treatment. A FeNO cut-off lower than 25 ppb should be considered irrelevant for this clinical application.","publisher":"Informa UK Limited","publication_name":"Annals of Medicine"},"translated_abstract":"Abstract Background. Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) has been considered a useful biomarker for predicting inhaled corticosteroids (ICS) response. We evaluated the relationship between FeNO and ICS response in chronic cough by performing a systematic review with meta-analysis. Methods. PubMed, Web of Science, Scopus and EMBASE databases were systematically searched. Differences were expressed as Odds Ratio (OR) with 95% confidence intervals (95%CI). Pooled sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), and area under the hierarchical summary receiver operating characteristic curve (HSROCAUC) were estimated. Results. Nine articles on 740 chronic-cough patients showed that the response rate to ICS was 87.4% (95%CI: 83.8–91.0) in 317 patients with a high FeNO and 46.3% (95%CI: 41.6–51.0) in 423 controls, with an attributable proportion of 47.0% and a diagnostic OR of 9.1 (95%CI: 3.7–22.4, p \u0026lt; .001). The pooled estimate of diagnostic indexes resulted in a sensitivity of 68.5% (95%CI: 46.7–84.4) and specificity of 81.9% (95%CI: 63.0–92.3), with a HSROCAUC of 0.82 (95%CI: 0.64–0.90). In a realistic scenario with a pre-test probability set at 30%, based on a pooled PLR of 3.79 (95%CI: 1.24–7.47) and NLR of 0.38 (95%CI: 0.22–0.66), the post-test probability was 62% with a high FeNO and 14% if the test was negative. Subgroup analyses confirmed a better performance for the recommended FeNO cut-off greater than 25 ppb. Meta-regression and sensitivity analyses showed no impact of major demographic and clinic variables on results. Conclusions. A high FeNO before starting ICS therapy may help identify chronic-cough patients responding to treatment, with a better performance ofhigher cut-off values. Further studies are needed to evaluate the real usefulness of this biomarker to guide cough therapy and optimise strategies in different healthcare settings (community, hospital, rehabilitation). Key messages Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) may be a useful biomarker for identifying chronic cough patients who respond to steroid treatment. A FeNO cut-off lower than 25 ppb should be considered irrelevant for this clinical application.","internal_url":"https://www.academia.edu/65513832/Performance_of_fractional_exhaled_nitric_oxide_in_predicting_response_to_inhaled_corticosteroids_in_chronic_cough_a_meta_analysis","translated_internal_url":"","created_at":"2021-12-22T07:42:43.125-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Performance_of_fractional_exhaled_nitric_oxide_in_predicting_response_to_inhaled_corticosteroids_in_chronic_cough_a_meta_analysis","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":15536792,"url":"https://www.tandfonline.com/doi/pdf/10.1080/07853890.2021.1979242"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513641"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513641/Comparison_of_three_different_exhaled_nitric_oxide_analyzers_in_chronic_respiratory_disorders"><img alt="Research paper thumbnail of Comparison of three different exhaled nitric oxide analyzers in chronic respiratory disorders" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513641/Comparison_of_three_different_exhaled_nitric_oxide_analyzers_in_chronic_respiratory_disorders">Comparison of three different exhaled nitric oxide analyzers in chronic respiratory disorders</a></div><div class="wp-workCard_item"><span>Journal of Breath Research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND Fractional exhaled nitric oxide (FeNO) measurement is a simple and non-invasive method...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND Fractional exhaled nitric oxide (FeNO) measurement is a simple and non-invasive method for monitoring eosinophilic airway inflammation. New portable analyzers for FeNO measurements are constantly being developed. The aim of our study was to evaluate the agreement of FeNO values measured by new portable analyzers. MATERIALS AND METHODS FeNO was measured in 20 healthy subjects, 20 asthmatic and 20 chronic obstructive pulmonary disease patients using the analyzers Niox-VERO, Vivatmo-PRO and HypAir-FeNO. A linear relationship was estimated with Pearson&#39;s coefficient (r), and absolute agreement by the intraclass correlation coefficient (ICC) and bias with the limits of agreement (95% of paired differences) were assessed according to the Bland-Altman method. RESULTS In the study population (58 ± 14 years, 20 females), mean values of FeNO with their 95% confidence interval were 24.0 (18.6-29.4) with the Niox-VERO, 19.6 (13.6-25.7) with the Vivatmo-PRO and 20.4 (15.7-25.1) with the HypAir-FeNO. FeNO measured with the Niox-VERO was higher than the Vivatmo-PRO (mean difference of paired values +4.3; limits -16.0 to 25.7 ppb) and the HypAir-FeNO (+3.6; -12.2 to 19.4 ppb); the Vivatmo-PRO and HypAir-FeNO showed large variability of paired differences (-0.7; -16.5 to 15.0 ppb). Measurements linearly correlated with an imperfect absolute agreement: Niox-VERO versus Vivatmo-PRO r = 0.90 and ICC = 0.87; Niox-VERO versus HypAir-FeNO r = 0.93 and ICC = 0.90, Vivatmo-PRO versus HypAir-FeNO r = 0.96 and ICC = 0.93. Most of the disagreement was greater in some asthmatic patients at high values of FeNO. CONCLUSIONS The present study indicates that absolute exhaled NO measurements may differ to a clinically relevant extent using the Niox-VERO, Vivatmo-PRO and HypAir-FeNO analyzers. The devices cannot be used interchangeably.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513641"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513641"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513641; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513641]").text(description); $(".js-view-count[data-work-id=65513641]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513641; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513641']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513641, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513641]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513641,"title":"Comparison of three different exhaled nitric oxide analyzers in chronic respiratory disorders","translated_title":"","metadata":{"abstract":"BACKGROUND Fractional exhaled nitric oxide (FeNO) measurement is a simple and non-invasive method for monitoring eosinophilic airway inflammation. New portable analyzers for FeNO measurements are constantly being developed. The aim of our study was to evaluate the agreement of FeNO values measured by new portable analyzers. MATERIALS AND METHODS FeNO was measured in 20 healthy subjects, 20 asthmatic and 20 chronic obstructive pulmonary disease patients using the analyzers Niox-VERO, Vivatmo-PRO and HypAir-FeNO. A linear relationship was estimated with Pearson\u0026#39;s coefficient (r), and absolute agreement by the intraclass correlation coefficient (ICC) and bias with the limits of agreement (95% of paired differences) were assessed according to the Bland-Altman method. RESULTS In the study population (58 ± 14 years, 20 females), mean values of FeNO with their 95% confidence interval were 24.0 (18.6-29.4) with the Niox-VERO, 19.6 (13.6-25.7) with the Vivatmo-PRO and 20.4 (15.7-25.1) with the HypAir-FeNO. FeNO measured with the Niox-VERO was higher than the Vivatmo-PRO (mean difference of paired values +4.3; limits -16.0 to 25.7 ppb) and the HypAir-FeNO (+3.6; -12.2 to 19.4 ppb); the Vivatmo-PRO and HypAir-FeNO showed large variability of paired differences (-0.7; -16.5 to 15.0 ppb). Measurements linearly correlated with an imperfect absolute agreement: Niox-VERO versus Vivatmo-PRO r = 0.90 and ICC = 0.87; Niox-VERO versus HypAir-FeNO r = 0.93 and ICC = 0.90, Vivatmo-PRO versus HypAir-FeNO r = 0.96 and ICC = 0.93. Most of the disagreement was greater in some asthmatic patients at high values of FeNO. CONCLUSIONS The present study indicates that absolute exhaled NO measurements may differ to a clinically relevant extent using the Niox-VERO, Vivatmo-PRO and HypAir-FeNO analyzers. The devices cannot be used interchangeably.","publisher":"IOP Publishing","publication_name":"Journal of Breath Research"},"translated_abstract":"BACKGROUND Fractional exhaled nitric oxide (FeNO) measurement is a simple and non-invasive method for monitoring eosinophilic airway inflammation. New portable analyzers for FeNO measurements are constantly being developed. The aim of our study was to evaluate the agreement of FeNO values measured by new portable analyzers. MATERIALS AND METHODS FeNO was measured in 20 healthy subjects, 20 asthmatic and 20 chronic obstructive pulmonary disease patients using the analyzers Niox-VERO, Vivatmo-PRO and HypAir-FeNO. A linear relationship was estimated with Pearson\u0026#39;s coefficient (r), and absolute agreement by the intraclass correlation coefficient (ICC) and bias with the limits of agreement (95% of paired differences) were assessed according to the Bland-Altman method. RESULTS In the study population (58 ± 14 years, 20 females), mean values of FeNO with their 95% confidence interval were 24.0 (18.6-29.4) with the Niox-VERO, 19.6 (13.6-25.7) with the Vivatmo-PRO and 20.4 (15.7-25.1) with the HypAir-FeNO. FeNO measured with the Niox-VERO was higher than the Vivatmo-PRO (mean difference of paired values +4.3; limits -16.0 to 25.7 ppb) and the HypAir-FeNO (+3.6; -12.2 to 19.4 ppb); the Vivatmo-PRO and HypAir-FeNO showed large variability of paired differences (-0.7; -16.5 to 15.0 ppb). Measurements linearly correlated with an imperfect absolute agreement: Niox-VERO versus Vivatmo-PRO r = 0.90 and ICC = 0.87; Niox-VERO versus HypAir-FeNO r = 0.93 and ICC = 0.90, Vivatmo-PRO versus HypAir-FeNO r = 0.96 and ICC = 0.93. Most of the disagreement was greater in some asthmatic patients at high values of FeNO. CONCLUSIONS The present study indicates that absolute exhaled NO measurements may differ to a clinically relevant extent using the Niox-VERO, Vivatmo-PRO and HypAir-FeNO analyzers. The devices cannot be used interchangeably.","internal_url":"https://www.academia.edu/65513641/Comparison_of_three_different_exhaled_nitric_oxide_analyzers_in_chronic_respiratory_disorders","translated_internal_url":"","created_at":"2021-12-22T07:41:02.647-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Comparison_of_three_different_exhaled_nitric_oxide_analyzers_in_chronic_respiratory_disorders","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":176994,"name":"Breath","url":"https://www.academia.edu/Documents/in/Breath"}],"urls":[{"id":15536727,"url":"http://iopscience.iop.org/article/10.1088/1752-7163/ab0167"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61185324"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61185324/Bronchodilator_Response_as_a_Possible_Predictor_of_Lung_Function_Improvement_After_Pulmonary_Rehabilitation_in_Post_COVID_19_Patients"><img alt="Research paper thumbnail of Bronchodilator Response as a Possible Predictor of Lung Function Improvement After Pulmonary Rehabilitation in Post-COVID-19 Patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61185324/Bronchodilator_Response_as_a_Possible_Predictor_of_Lung_Function_Improvement_After_Pulmonary_Rehabilitation_in_Post_COVID_19_Patients">Bronchodilator Response as a Possible Predictor of Lung Function Improvement After Pulmonary Rehabilitation in Post-COVID-19 Patients</a></div><div class="wp-workCard_item"><span>Archivos de Bronconeumología</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61185324"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61185324"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61185324; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="6487458" id="papers"><div class="js-work-strip profile--work_container" data-work-id="78747867"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78747867/INDACO_project_COPD_and_link_between_comorbidities_lung_function_and_inhalation_therapy"><img alt="Research paper thumbnail of INDACO project: COPD and link between comorbidities, lung function and inhalation therapy" class="work-thumbnail" src="https://attachments.academia-assets.com/85685142/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78747867/INDACO_project_COPD_and_link_between_comorbidities_lung_function_and_inhalation_therapy">INDACO project: COPD and link between comorbidities, lung function and inhalation therapy</a></div><div class="wp-workCard_item"><span>Multidisciplinary Respiratory Medicine</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4a398851228af8ce8a3f99c011682f69" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85685142,"asset_id":78747867,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85685142/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78747867"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78747867"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78747867; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78747867]").text(description); $(".js-view-count[data-work-id=78747867]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78747867; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78747867']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78747867, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4a398851228af8ce8a3f99c011682f69" } } $('.js-work-strip[data-work-id=78747867]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78747867,"title":"INDACO project: COPD and link between comorbidities, lung function and inhalation therapy","translated_title":"","metadata":{"publisher":"PAGEPress Publications","grobid_abstract":"Background: Chronic Obstructive Pulmonary Disease (COPD) is characterized by respiratory and extrarespiratory components referring both to systemic complications of COPD, like skeletal muscle myopathy, weight loss and others, and frequently associated comorbidities, interesting various organs and systems (cardiovascular diseases, malignancies, osteoporosis, diabetes, etc.). These comorbidities may increase the rate of hospitalization of COPD patients and have a huge effect on the outcomes of the respiratory disease. Inhalation therapy of COPD with bronchodilators and steroid is primary driven by airflow obstruction, symptoms like dyspnoea, and acute exacerbations. INDACO project has been developed in 2013 to assess the prevalence and type of comorbidities in COPD patients referred to the outpatient wards of some hospitals in Central and South Italy and a preliminary report has recently been published. In the present study, after widening that database, we evaluate the prevalence of comorbidities and the relationships between comorbidities and sex, age, symptoms, lung function and inhalation therapy in COPD patients. Methods: In each enrolled patient, anthropometric and anamnestic data, smoking habits, respiratory function, GOLD (Global initiative for Chronic Obstructive Lung Disease) severity stage, Body Mass Index (BMI), number of acute COPD exacerbations in previous years, presence and type of comorbidities, and the Charlson Comorbidity Index (CCI) were recorded. Results: We collected data of 569 patients (395 males and 174 females, mean age 73 ± 8.5 yrs). The prevalence of patients with comorbidities was 81.2%. Overall number of comorbidities was not related to airflow obstruction and age, but to acute exacerbation of COPD, dyspnoea measured with MRC scale, and male gender. A subgroup analysis revealed that ischaemic heart disease was predominant in males, whereas mood disorders in females. The use of a more complex (multi-drug) inhalation therapy was related with bronchial obstruction measured by FEV 1 /FVC (p for trend = 0.003) and number of comorbidities (p for trend = 0.001). In multivariate analysis, only airflow obstruction and number of comorbidities were determinant of complexity of therapy, but not MRC and acute exacerbation of COPD. However, the statistical model reached an extreme low degree of significance (r^2 = 0.07). Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Multidisciplinary Respiratory Medicine","grobid_abstract_attachment_id":85685142},"translated_abstract":null,"internal_url":"https://www.academia.edu/78747867/INDACO_project_COPD_and_link_between_comorbidities_lung_function_and_inhalation_therapy","translated_internal_url":"","created_at":"2022-05-08T05:45:22.232-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":85685142,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/85685142/thumbnails/1.jpg","file_name":"2049-6958-10-4.pdf","download_url":"https://www.academia.edu/attachments/85685142/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"INDACO_project_COPD_and_link_between_com.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/85685142/2049-6958-10-4-libre.pdf?1652015139=\u0026response-content-disposition=attachment%3B+filename%3DINDACO_project_COPD_and_link_between_com.pdf\u0026Expires=1732704095\u0026Signature=UdEfang3-fJliHnLg-qCTZI39rg2BAuHvVxGwS0KLoIEyRBnet2AgqMvdmrJFqIAvi6HvQw50dxt~LVGbExhXF5PGw0-PYMmq8laSK8kwEQzUoQTCtt6Y3aycW2j55yPKFvMsk~UBUf7b97iqOW3j6idN74ApMY6Y47khylFwPJLDF2o6AJUVKPM7WoeaUlzRp08HiWh4LqN39nUdPa1w8148OCdeCFkxWomlTGYo-bLxZQEIm9rur01U1NT0C~TD0eOgqPuCvikfHyiE0aTUA1A4-Fr2hy-OOBxh61q9ne4r~Q0iZoOG1dE7vvcSem3T0Gma4IuHMXXsS9tkIgZtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"INDACO_project_COPD_and_link_between_comorbidities_lung_function_and_inhalation_therapy","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[{"id":85685142,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/85685142/thumbnails/1.jpg","file_name":"2049-6958-10-4.pdf","download_url":"https://www.academia.edu/attachments/85685142/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"INDACO_project_COPD_and_link_between_com.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/85685142/2049-6958-10-4-libre.pdf?1652015139=\u0026response-content-disposition=attachment%3B+filename%3DINDACO_project_COPD_and_link_between_com.pdf\u0026Expires=1732704095\u0026Signature=UdEfang3-fJliHnLg-qCTZI39rg2BAuHvVxGwS0KLoIEyRBnet2AgqMvdmrJFqIAvi6HvQw50dxt~LVGbExhXF5PGw0-PYMmq8laSK8kwEQzUoQTCtt6Y3aycW2j55yPKFvMsk~UBUf7b97iqOW3j6idN74ApMY6Y47khylFwPJLDF2o6AJUVKPM7WoeaUlzRp08HiWh4LqN39nUdPa1w8148OCdeCFkxWomlTGYo-bLxZQEIm9rur01U1NT0C~TD0eOgqPuCvikfHyiE0aTUA1A4-Fr2hy-OOBxh61q9ne4r~Q0iZoOG1dE7vvcSem3T0Gma4IuHMXXsS9tkIgZtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[{"id":20321567,"url":"http://link.springer.com/content/pdf/10.1186/2049-6958-10-4.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78747865"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78747865/Cognitive_Impairment_in_Convalescent_COVID_19_Patients_Undergoing_Multidisciplinary_Rehabilitation_The_Association_with_the_Clinical_and_Functional_Status"><img alt="Research paper thumbnail of Cognitive Impairment in Convalescent COVID-19 Patients Undergoing Multidisciplinary Rehabilitation: The Association with the Clinical and Functional Status" class="work-thumbnail" src="https://attachments.academia-assets.com/85685134/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78747865/Cognitive_Impairment_in_Convalescent_COVID_19_Patients_Undergoing_Multidisciplinary_Rehabilitation_The_Association_with_the_Clinical_and_Functional_Status">Cognitive Impairment in Convalescent COVID-19 Patients Undergoing Multidisciplinary Rehabilitation: The Association with the Clinical and Functional Status</a></div><div class="wp-workCard_item"><span>Healthcare</span><span>, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) infection. We investigated the possible association between cognitive impairment and the main clinical and functional status variables in a cohort of convalescent COVID-19 patients without premorbid diseases potentially affecting cognition. Methods. We consecutively screened for inclusion of convalescent COVID-19 patients referring to a post-acute care facility for pulmonary rehabilitation. All the enrolled patients were assessed for cognitive functions. We also investigated features of psychological distress (anxiety, depression, symptoms of posttraumatic stress disorder and quality of life) and cardiac and pulmonary functional status. Results. The 63 enrolled patients (mean age 59.82 ± 10.78, male gender = 47) showed a high frequency of depressive symptoms (76.2%) and anxiety (55.5%), and a high prevalence of symptoms of posttraumatic stress di...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="21d9c7085f06e34f945964a1e1a88edb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85685134,"asset_id":78747865,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85685134/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78747865"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78747865"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78747865; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78747865]").text(description); $(".js-view-count[data-work-id=78747865]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78747865; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78747865']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78747865, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "21d9c7085f06e34f945964a1e1a88edb" } } $('.js-work-strip[data-work-id=78747865]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78747865,"title":"Cognitive Impairment in Convalescent COVID-19 Patients Undergoing Multidisciplinary Rehabilitation: The Association with the Clinical and Functional Status","translated_title":"","metadata":{"abstract":"Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) infection. We investigated the possible association between cognitive impairment and the main clinical and functional status variables in a cohort of convalescent COVID-19 patients without premorbid diseases potentially affecting cognition. Methods. We consecutively screened for inclusion of convalescent COVID-19 patients referring to a post-acute care facility for pulmonary rehabilitation. All the enrolled patients were assessed for cognitive functions. We also investigated features of psychological distress (anxiety, depression, symptoms of posttraumatic stress disorder and quality of life) and cardiac and pulmonary functional status. Results. The 63 enrolled patients (mean age 59.82 ± 10.78, male gender = 47) showed a high frequency of depressive symptoms (76.2%) and anxiety (55.5%), and a high prevalence of symptoms of posttraumatic stress di...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2022,"errors":{}},"publication_name":"Healthcare"},"translated_abstract":"Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) infection. We investigated the possible association between cognitive impairment and the main clinical and functional status variables in a cohort of convalescent COVID-19 patients without premorbid diseases potentially affecting cognition. Methods. We consecutively screened for inclusion of convalescent COVID-19 patients referring to a post-acute care facility for pulmonary rehabilitation. All the enrolled patients were assessed for cognitive functions. We also investigated features of psychological distress (anxiety, depression, symptoms of posttraumatic stress disorder and quality of life) and cardiac and pulmonary functional status. Results. The 63 enrolled patients (mean age 59.82 ± 10.78, male gender = 47) showed a high frequency of depressive symptoms (76.2%) and anxiety (55.5%), and a high prevalence of symptoms of posttraumatic stress di...","internal_url":"https://www.academia.edu/78747865/Cognitive_Impairment_in_Convalescent_COVID_19_Patients_Undergoing_Multidisciplinary_Rehabilitation_The_Association_with_the_Clinical_and_Functional_Status","translated_internal_url":"","created_at":"2022-05-08T05:45:15.118-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":85685134,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/85685134/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/85685134/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cognitive_Impairment_in_Convalescent_COV.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/85685134/pdf-libre.pdf?1652015138=\u0026response-content-disposition=attachment%3B+filename%3DCognitive_Impairment_in_Convalescent_COV.pdf\u0026Expires=1732704095\u0026Signature=RIXYMo4TA~57p9-zWMhSfivxLhdgWpLxPV2YrSJZywD8a7EZ2EvkmRG4tC6I1R4Br2CughNolimkSCSucSWTlGJQy9XdyZXV~omVDxWsDgi-f3GwpwadSCVso0lzSg-xgZ1v4dC1oYRHexi1CBQSoBDlkf5c-GXTX0kWR4kiTKIwTPh6Ank6ze~UPWd~qx-7MJB1p-ZfhWWEadUWcuVVk7dvRAb1aTcvMxUmPpJ7vwaADWP6hj1jAGDqjbSKNOG5dsIzie2NvBB2POEN0Y2toVxg6IXtit~AqyJWcMEEf1Af5zux-z5DwpoLIXCeZQfDU2HkjXHT15Y-anoZcaiZqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cognitive_Impairment_in_Convalescent_COVID_19_Patients_Undergoing_Multidisciplinary_Rehabilitation_The_Association_with_the_Clinical_and_Functional_Status","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[{"id":85685134,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/85685134/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/85685134/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cognitive_Impairment_in_Convalescent_COV.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/85685134/pdf-libre.pdf?1652015138=\u0026response-content-disposition=attachment%3B+filename%3DCognitive_Impairment_in_Convalescent_COV.pdf\u0026Expires=1732704095\u0026Signature=RIXYMo4TA~57p9-zWMhSfivxLhdgWpLxPV2YrSJZywD8a7EZ2EvkmRG4tC6I1R4Br2CughNolimkSCSucSWTlGJQy9XdyZXV~omVDxWsDgi-f3GwpwadSCVso0lzSg-xgZ1v4dC1oYRHexi1CBQSoBDlkf5c-GXTX0kWR4kiTKIwTPh6Ank6ze~UPWd~qx-7MJB1p-ZfhWWEadUWcuVVk7dvRAb1aTcvMxUmPpJ7vwaADWP6hj1jAGDqjbSKNOG5dsIzie2NvBB2POEN0Y2toVxg6IXtit~AqyJWcMEEf1Af5zux-z5DwpoLIXCeZQfDU2HkjXHT15Y-anoZcaiZqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":29393,"name":"Healthcare","url":"https://www.academia.edu/Documents/in/Healthcare"}],"urls":[{"id":20321565,"url":"https://www.mdpi.com/2227-9032/10/3/480/pdf"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514189"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514189/Metabolomics_of_COPD_Pulmonary_Rehabilitation_Outcomes_via_Exhaled_Breath_Condensate"><img alt="Research paper thumbnail of Metabolomics of COPD Pulmonary Rehabilitation Outcomes via Exhaled Breath Condensate" class="work-thumbnail" src="https://attachments.academia-assets.com/81411911/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514189/Metabolomics_of_COPD_Pulmonary_Rehabilitation_Outcomes_via_Exhaled_Breath_Condensate">Metabolomics of COPD Pulmonary Rehabilitation Outcomes via Exhaled Breath Condensate</a></div><div class="wp-workCard_item"><span>Cells</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chronic obstructive pulmonary disease (COPD) is characterized by different phenotypes and clinica...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chronic obstructive pulmonary disease (COPD) is characterized by different phenotypes and clinical presentations. Therefore, a single strategy of pulmonary rehabilitation (PR) does not always yield the expected clinical outcomes as some individuals respond excellently, others discreetly, or do not respond at all. Fifty consecutive COPD patients were enrolled. Of them, 35 starting a 5-week PR program were sampled at admission (T0), after 2 (T2W) and 5 (T5W) weeks, while 15 controls not yet on PR were tested at T0 and T5W. Nuclear magnetic resonance (NMR) profiling of exhaled breath condensate (EBC) and multivariate statistical analysis were applied to investigate the relationship between biomarkers and clinical parameters. The model including the three classes correctly located T2W between T0 and T5W, but 38.71% of samples partially overlapped with T0 and 32.26% with T5W, suggesting that for some patients PR is already beneficial at T2W (32.26% overlapping with T5W), while for others...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9aa5b92bf4707c18ec8cf2472764397d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81411911,"asset_id":72514189,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81411911/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514189; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514189]").text(description); $(".js-view-count[data-work-id=72514189]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514189; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514189']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514189, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9aa5b92bf4707c18ec8cf2472764397d" } } $('.js-work-strip[data-work-id=72514189]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514189,"title":"Metabolomics of COPD Pulmonary Rehabilitation Outcomes via Exhaled Breath Condensate","translated_title":"","metadata":{"abstract":"Chronic obstructive pulmonary disease (COPD) is characterized by different phenotypes and clinical presentations. Therefore, a single strategy of pulmonary rehabilitation (PR) does not always yield the expected clinical outcomes as some individuals respond excellently, others discreetly, or do not respond at all. Fifty consecutive COPD patients were enrolled. Of them, 35 starting a 5-week PR program were sampled at admission (T0), after 2 (T2W) and 5 (T5W) weeks, while 15 controls not yet on PR were tested at T0 and T5W. Nuclear magnetic resonance (NMR) profiling of exhaled breath condensate (EBC) and multivariate statistical analysis were applied to investigate the relationship between biomarkers and clinical parameters. The model including the three classes correctly located T2W between T0 and T5W, but 38.71% of samples partially overlapped with T0 and 32.26% with T5W, suggesting that for some patients PR is already beneficial at T2W (32.26% overlapping with T5W), while for others...","publisher":"MDPI AG","publication_name":"Cells"},"translated_abstract":"Chronic obstructive pulmonary disease (COPD) is characterized by different phenotypes and clinical presentations. Therefore, a single strategy of pulmonary rehabilitation (PR) does not always yield the expected clinical outcomes as some individuals respond excellently, others discreetly, or do not respond at all. Fifty consecutive COPD patients were enrolled. Of them, 35 starting a 5-week PR program were sampled at admission (T0), after 2 (T2W) and 5 (T5W) weeks, while 15 controls not yet on PR were tested at T0 and T5W. Nuclear magnetic resonance (NMR) profiling of exhaled breath condensate (EBC) and multivariate statistical analysis were applied to investigate the relationship between biomarkers and clinical parameters. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514188"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514188/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease"><img alt="Research paper thumbnail of Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease" class="work-thumbnail" src="https://attachments.academia-assets.com/81411910/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514188/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease">Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease</a></div><div class="wp-workCard_item"><span>Respiratory care</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="25bd51426c7ef6a329c061fd923e30e4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81411910,"asset_id":72514188,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81411910/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514188; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514188]").text(description); $(".js-view-count[data-work-id=72514188]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514188; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514188']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514188, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "25bd51426c7ef6a329c061fd923e30e4" } } $('.js-work-strip[data-work-id=72514188]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514188,"title":"Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease","translated_title":"","metadata":{"abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. 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We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Respiratory care"},"translated_abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514187"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514187/Therapy"><img alt="Research paper thumbnail of Therapy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514187/Therapy">Therapy</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Full list of author information is available at the end of the articlenumber of comorbidities wer...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Full list of author information is available at the end of the articlenumber of comorbidities were determinant of complexity of therapy, but not MRC and acute exacerbation of COPD. However, the statistical model reached an extreme low degree of significance (r^2 = 0.07). Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514187"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514187"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514187; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514187]").text(description); $(".js-view-count[data-work-id=72514187]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514187; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514187']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514187, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72514187]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514187,"title":"Therapy","translated_title":"","metadata":{"abstract":"Full list of author information is available at the end of the articlenumber of comorbidities were determinant of complexity of therapy, but not MRC and acute exacerbation of COPD. However, the statistical model reached an extreme low degree of significance (r^2 = 0.07). Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}}},"translated_abstract":"Full list of author information is available at the end of the articlenumber of comorbidities were determinant of complexity of therapy, but not MRC and acute exacerbation of COPD. However, the statistical model reached an extreme low degree of significance (r^2 = 0.07). Conclusions: Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.","internal_url":"https://www.academia.edu/72514187/Therapy","translated_internal_url":"","created_at":"2022-02-26T13:34:37.962-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Therapy","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":65341,"name":"COPD","url":"https://www.academia.edu/Documents/in/COPD"},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking"},{"id":135852,"name":"BMI","url":"https://www.academia.edu/Documents/in/BMI"},{"id":1383212,"name":"Comorbidities","url":"https://www.academia.edu/Documents/in/Comorbidities"}],"urls":[{"id":18048869,"url":"http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.812.3013\u0026rep=rep1\u0026type=pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514186"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514186/Metabolomics_approach_applied_to_exhaled_breath_condensate_in_lung_cancer"><img alt="Research paper thumbnail of Metabolomics approach applied to exhaled breath condensate in lung cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514186/Metabolomics_approach_applied_to_exhaled_breath_condensate_in_lung_cancer">Metabolomics approach applied to exhaled breath condensate in lung cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several studies on lung cancer research have been performed with the aim of revealing biomarkers ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several studies on lung cancer research have been performed with the aim of revealing biomarkers representative of the cancer phenotype as well as possible therapeutic targets. This has led to the identification of many molecular features involved in lung cancer with new biochemical adaptations in the carcinogenetic process with quantitative changes in endogenous metabolites [1]. Recently, omics sciences have arising interest in cancer research as they could potentially detect new biomarkers, improving disease diagnosis and evaluating the effect of the treatment [2]. Among all omics, metabolomics is currently, one of the fastest developing disciplines in cancer research. In fact, metabolomics is the comprehensive assessment of endogenous metabolites (metabolome) and attempts to systematically identify and quantify metabolites from a biological specimen in a both global and targeted manner [3, 4]. The application of metabolomics to cancer is increasing year by year in the search for ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514186"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514186"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514186; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514186]").text(description); $(".js-view-count[data-work-id=72514186]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514186; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514186']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514186, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=72514186]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514186,"title":"Metabolomics approach applied to exhaled breath condensate in lung cancer","translated_title":"","metadata":{"abstract":"Several studies on lung cancer research have been performed with the aim of revealing biomarkers representative of the cancer phenotype as well as possible therapeutic targets. 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The application of metabolomics to cancer is increasing year by year in the search for ...","publication_date":{"day":null,"month":null,"year":2017,"errors":{}}},"translated_abstract":"Several studies on lung cancer research have been performed with the aim of revealing biomarkers representative of the cancer phenotype as well as possible therapeutic targets. This has led to the identification of many molecular features involved in lung cancer with new biochemical adaptations in the carcinogenetic process with quantitative changes in endogenous metabolites [1]. Recently, omics sciences have arising interest in cancer research as they could potentially detect new biomarkers, improving disease diagnosis and evaluating the effect of the treatment [2]. Among all omics, metabolomics is currently, one of the fastest developing disciplines in cancer research. In fact, metabolomics is the comprehensive assessment of endogenous metabolites (metabolome) and attempts to systematically identify and quantify metabolites from a biological specimen in a both global and targeted manner [3, 4]. The application of metabolomics to cancer is increasing year by year in the search for ...","internal_url":"https://www.academia.edu/72514186/Metabolomics_approach_applied_to_exhaled_breath_condensate_in_lung_cancer","translated_internal_url":"","created_at":"2022-02-26T13:34:37.821-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Metabolomics_approach_applied_to_exhaled_breath_condensate_in_lung_cancer","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="72514180"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/72514180/Case_Reports_Severe_Respiratory_and_Skeletal_Muscles_Involvement_in_a_Carrier_of_Dysferlinopathy_With_Chronic_Obstructive_Pulmonary_Disease"><img alt="Research paper thumbnail of Case Reports Severe Respiratory and Skeletal Muscles Involvement in a Carrier of Dysferlinopathy With Chronic Obstructive Pulmonary Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/81411943/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/72514180/Case_Reports_Severe_Respiratory_and_Skeletal_Muscles_Involvement_in_a_Carrier_of_Dysferlinopathy_With_Chronic_Obstructive_Pulmonary_Disease">Case Reports Severe Respiratory and Skeletal Muscles Involvement in a Carrier of Dysferlinopathy With Chronic Obstructive Pulmonary Disease</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The natural course of progressive neuromuscular diseases can be complicated by respiratory mus-cl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The natural course of progressive neuromuscular diseases can be complicated by respiratory mus-cle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally oc-curs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment. Key words: chronic obstructive pulmonary disease; respirator...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="531bc4dfa8a8b8ab3be42759f9c6ddd2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":81411943,"asset_id":72514180,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/81411943/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="72514180"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="72514180"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72514180; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72514180]").text(description); $(".js-view-count[data-work-id=72514180]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72514180; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='72514180']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 72514180, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "531bc4dfa8a8b8ab3be42759f9c6ddd2" } } $('.js-work-strip[data-work-id=72514180]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":72514180,"title":"Case Reports Severe Respiratory and Skeletal Muscles Involvement in a Carrier of Dysferlinopathy With Chronic Obstructive Pulmonary Disease","translated_title":"","metadata":{"abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory mus-cle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally oc-curs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment. Key words: chronic obstructive pulmonary disease; respirator...","publication_date":{"day":null,"month":null,"year":2016,"errors":{}}},"translated_abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory mus-cle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally oc-curs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment. Key words: chronic obstructive pulmonary disease; respirator...","internal_url":"https://www.academia.edu/72514180/Case_Reports_Severe_Respiratory_and_Skeletal_Muscles_Involvement_in_a_Carrier_of_Dysferlinopathy_With_Chronic_Obstructive_Pulmonary_Disease","translated_internal_url":"","created_at":"2022-02-26T13:34:10.058-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":81411943,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411943/thumbnails/1.jpg","file_name":"1091.full.pdf","download_url":"https://www.academia.edu/attachments/81411943/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Reports_Severe_Respiratory_and_Skel.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411943/1091.full-libre.pdf?1645911606=\u0026response-content-disposition=attachment%3B+filename%3DCase_Reports_Severe_Respiratory_and_Skel.pdf\u0026Expires=1732704096\u0026Signature=buPkZS7Wsclrwe-pdDXTileN1NnDoPQsM4F~UY272T~iGYruSPLyZnNUYgUQJ4GB726CaEUbf6JZuBZNRM5kR29P43lVgT6YkzT1Xvgm7SlTo7O8jWqhMv~ONAa-IFCBOd0YnHMhyI5XX7I2RtfdcRPqrg454Mffbvsokyv91EPaWTHfqpJ5~6dFmGApb4KOn~X~DtsGn4dduEjBZFVJAbt-p6jyVPO8vBM8W2KnApQ73glZj28Etz420fZVKPJ0PijRfTvir3qdtROmMuSWAtFgGRDaY5d6RPwgUws2sSOaW1A5Iwm5MjwFklwAJpUJHBC1YQ7Zh8yyW~jzQSo-Lw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Case_Reports_Severe_Respiratory_and_Skeletal_Muscles_Involvement_in_a_Carrier_of_Dysferlinopathy_With_Chronic_Obstructive_Pulmonary_Disease","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[{"id":81411943,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/81411943/thumbnails/1.jpg","file_name":"1091.full.pdf","download_url":"https://www.academia.edu/attachments/81411943/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Reports_Severe_Respiratory_and_Skel.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/81411943/1091.full-libre.pdf?1645911606=\u0026response-content-disposition=attachment%3B+filename%3DCase_Reports_Severe_Respiratory_and_Skel.pdf\u0026Expires=1732704096\u0026Signature=buPkZS7Wsclrwe-pdDXTileN1NnDoPQsM4F~UY272T~iGYruSPLyZnNUYgUQJ4GB726CaEUbf6JZuBZNRM5kR29P43lVgT6YkzT1Xvgm7SlTo7O8jWqhMv~ONAa-IFCBOd0YnHMhyI5XX7I2RtfdcRPqrg454Mffbvsokyv91EPaWTHfqpJ5~6dFmGApb4KOn~X~DtsGn4dduEjBZFVJAbt-p6jyVPO8vBM8W2KnApQ73glZj28Etz420fZVKPJ0PijRfTvir3qdtROmMuSWAtFgGRDaY5d6RPwgUws2sSOaW1A5Iwm5MjwFklwAJpUJHBC1YQ7Zh8yyW~jzQSo-Lw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":18048865,"url":"http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.989.4353\u0026rep=rep1\u0026type=pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513838"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513838/Portable_oxygen_concentrator_vesus_oxygen_cylinder_in_chronic_lung_disease_patient_preferences_and_psychological_implications"><img alt="Research paper thumbnail of Portable oxygen concentrator vesus oxygen cylinder in chronic lung disease: patient preferences and psychological implications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513838/Portable_oxygen_concentrator_vesus_oxygen_cylinder_in_chronic_lung_disease_patient_preferences_and_psychological_implications">Portable oxygen concentrator vesus oxygen cylinder in chronic lung disease: patient preferences and psychological implications</a></div><div class="wp-workCard_item"><span>European Respiratory Journal</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513838"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513838"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513838; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513836"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513836/A_Rapid_Antigen_Detection_Test_to_Diagnose_SARS_CoV_2_Infection_Using_Exhaled_Breath_Condensate_by_A_Modified_Inflammacheck_Device"><img alt="Research paper thumbnail of A Rapid Antigen Detection Test to Diagnose SARS-CoV-2 Infection Using Exhaled Breath Condensate by A Modified Inflammacheck® Device" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513836/A_Rapid_Antigen_Detection_Test_to_Diagnose_SARS_CoV_2_Infection_Using_Exhaled_Breath_Condensate_by_A_Modified_Inflammacheck_Device">A Rapid Antigen Detection Test to Diagnose SARS-CoV-2 Infection Using Exhaled Breath Condensate by A Modified Inflammacheck® Device</a></div><div class="wp-workCard_item"><span>Sensors (Basel, Switzerland)</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: The standard test that identifies the severe acute respiratory syndrome coronavirus-2...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: The standard test that identifies the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is based on reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal (NP) swab specimens. We compared the accuracy of a rapid antigen detection test using exhaled breath condensate by a modified Inflammacheck® device with the standard RT-PCR to diagnose SARS-CoV-2 infection. Methods: We performed a manufacturer-independent, cross-sectional, diagnostic accuracy study involving two Italian hospitals. Sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), positive (PPV) and negative predictive value (NPV) and diagnostic accuracy with 95% confidence intervals (95% CI) of Inflammacheck® were calculated using the RT-PCR results as the standard. Further RT-PCR tests were conducted on NP specimens from test positive subjects to obtain the Ct (cycle threshold) values as indicative evidence of the viral load. Results: A total of 105 individu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513836"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513836"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513836; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513836]").text(description); $(".js-view-count[data-work-id=65513836]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513836; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513836']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513836, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513836]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513836,"title":"A Rapid Antigen Detection Test to Diagnose SARS-CoV-2 Infection Using Exhaled Breath Condensate by A Modified Inflammacheck® Device","translated_title":"","metadata":{"abstract":"Background: The standard test that identifies the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is based on reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal (NP) swab specimens. We compared the accuracy of a rapid antigen detection test using exhaled breath condensate by a modified Inflammacheck® device with the standard RT-PCR to diagnose SARS-CoV-2 infection. Methods: We performed a manufacturer-independent, cross-sectional, diagnostic accuracy study involving two Italian hospitals. Sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), positive (PPV) and negative predictive value (NPV) and diagnostic accuracy with 95% confidence intervals (95% CI) of Inflammacheck® were calculated using the RT-PCR results as the standard. Further RT-PCR tests were conducted on NP specimens from test positive subjects to obtain the Ct (cycle threshold) values as indicative evidence of the viral load. Results: A total of 105 individu...","publisher":"Sensors","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Sensors (Basel, Switzerland)"},"translated_abstract":"Background: The standard test that identifies the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is based on reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal (NP) swab specimens. We compared the accuracy of a rapid antigen detection test using exhaled breath condensate by a modified Inflammacheck® device with the standard RT-PCR to diagnose SARS-CoV-2 infection. Methods: We performed a manufacturer-independent, cross-sectional, diagnostic accuracy study involving two Italian hospitals. Sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), positive (PPV) and negative predictive value (NPV) and diagnostic accuracy with 95% confidence intervals (95% CI) of Inflammacheck® were calculated using the RT-PCR results as the standard. Further RT-PCR tests were conducted on NP specimens from test positive subjects to obtain the Ct (cycle threshold) values as indicative evidence of the viral load. Results: A total of 105 individu...","internal_url":"https://www.academia.edu/65513836/A_Rapid_Antigen_Detection_Test_to_Diagnose_SARS_CoV_2_Infection_Using_Exhaled_Breath_Condensate_by_A_Modified_Inflammacheck_Device","translated_internal_url":"","created_at":"2021-12-22T07:42:43.640-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_Rapid_Antigen_Detection_Test_to_Diagnose_SARS_CoV_2_Infection_Using_Exhaled_Breath_Condensate_by_A_Modified_Inflammacheck_Device","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[{"id":15536794,"url":"https://doi.org/10.3390/s21175710"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513834"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513834/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease"><img alt="Research paper thumbnail of Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease" class="work-thumbnail" src="https://attachments.academia-assets.com/77076775/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513834/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease">Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="908ab157fa32febf55b589e1614ab935" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77076775,"asset_id":65513834,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77076775/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513834"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513834"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513834; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513834]").text(description); $(".js-view-count[data-work-id=65513834]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513834; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513834']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513834, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "908ab157fa32febf55b589e1614ab935" } } $('.js-work-strip[data-work-id=65513834]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513834,"title":"Severe respiratory and skeletal muscles involvement in a carrier of dysferlinopathy with chronic obstructive pulmonary disease","translated_title":"","metadata":{"abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. 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We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.","publisher":"Respiratory care","publication_date":{"day":null,"month":null,"year":2010,"errors":{}}},"translated_abstract":"The natural course of progressive neuromuscular diseases can be complicated by respiratory muscle involvement. In muscular dystrophies such as Duchenne muscular dystrophy and myotonic dystrophy, respiratory muscle involvement is common. In others such as Becker, limb-girdle, and facioscapulo-humeral dystrophies, respiratory muscle involvement is infrequent and generally occurs in the more severe cases. Recently, it was reported that a mutation in the dysferlin gene and/or dysferlin deficiency causes proximal and distal forms of muscular dystrophy, which are known by the term dysferlinopathy. We describe a case of severe weakness of both limb-girdle and respiratory muscles in a patient who was carrier of the dysferlin gene mutation and who also had COPD. We suggest that the systemic inflammatory response of COPD and the dysferlin deficit interact and are responsible for both the skeletal and respiratory muscle impairment.","internal_url":"https://www.academia.edu/65513834/Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease","translated_internal_url":"","created_at":"2021-12-22T07:42:43.384-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77076775,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77076775/thumbnails/1.jpg","file_name":"1091.full.pdf","download_url":"https://www.academia.edu/attachments/77076775/download_file?st=MTczMjcwMDQ5OCw4LjIyMi4yMDguMTQ2&st=MTczMjcwMDQ5Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Severe_respiratory_and_skeletal_muscles.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77076775/1091.full-libre.pdf?1640295440=\u0026response-content-disposition=attachment%3B+filename%3DSevere_respiratory_and_skeletal_muscles.pdf\u0026Expires=1732704096\u0026Signature=EFMtAYDHnAeLeJlyBM6Ty3rMzpIEmKI-yC1GGSO8R61ZH9M-C74SMxyUiPT-R8YxG~E-k9urPbNEshz7tGK~vRd0P16aOfnK7oaq2VWp5xYxLGlpetpykfPgD2TxFrGaKaA6tJP3e2vChuco2-liO-duvab~V7sK27N50G6MF4BcgPKZggTWZiXmWl4SCbdI3SwF~8T7ECEqUwtrNOwydZCfcBlV7jZ8sNXvoyh~Ar7qney0hGzppRVP0WLZbi-KNJ~JhRdlyoh3s8tmfh2P~nD0m-1gfECRuXt469QRoDLcSUipNC-V0VHIZcj5gwppVq~C9jKGS6VnvBNu2xiHDQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Severe_respiratory_and_skeletal_muscles_involvement_in_a_carrier_of_dysferlinopathy_with_chronic_obstructive_pulmonary_disease","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore 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Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins"},{"id":98995,"name":"Muscular Dystrophies","url":"https://www.academia.edu/Documents/in/Muscular_Dystrophies"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":309137,"name":"Respiratory Muscles","url":"https://www.academia.edu/Documents/in/Respiratory_Muscles"},{"id":556576,"name":"Chronic obstructive pulmonary disease","url":"https://www.academia.edu/Documents/in/Chronic_obstructive_pulmonary_disease"},{"id":876966,"name":"Blood gas analysis","url":"https://www.academia.edu/Documents/in/Blood_gas_analysis"},{"id":1640066,"name":"Respiratory Care","url":"https://www.academia.edu/Documents/in/Respiratory_Care"},{"id":3063336,"name":"Respiratory function tests","url":"https://www.academia.edu/Documents/in/Respiratory_function_tests"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":15536793,"url":"http://rc.rcjournal.com/content/respcare/55/8/1091.full.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513833"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513833/Subject_Preferences_and_Psychological_Implications_of_Portable_Oxygen_Concentrator_Versus_Compressed_Oxygen_Cylinder_in_Chronic_Lung_Disease"><img alt="Research paper thumbnail of Subject Preferences and Psychological Implications of Portable Oxygen Concentrator Versus Compressed Oxygen Cylinder in Chronic Lung Disease" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513833/Subject_Preferences_and_Psychological_Implications_of_Portable_Oxygen_Concentrator_Versus_Compressed_Oxygen_Cylinder_in_Chronic_Lung_Disease">Subject Preferences and Psychological Implications of Portable Oxygen Concentrator Versus Compressed Oxygen Cylinder in Chronic Lung Disease</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND: Oxygen therapy represents the elective therapy to improve the quality of life for pat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND: Oxygen therapy represents the elective therapy to improve the quality of life for patients with chronic respiratory diseases like COPD and interstitial lung disease. Lightweight portable oxygen concentrators (POCs) are a valid alternative to traditional systems such as portable compressed oxygen cylinders. However, patient preference and the possible psychological implications related to the use of both devices have been poorly assessed. We sought to evaluate patient preference between the ambulatory oxygen systems (ie, a POC or a small cylinder) for patients with COPD and interstitial lung disease experiencing exertional desaturation in a rehabilitation setting. Furthermore, the use of one device in comparison with the other was related to specific mechanical characteristics and related to perceived quality of life, anxiety, and depressive symptoms. METHODS: 30 subjects with COPD and interstitial lung disease, who demonstrated exertional desaturation on room air during ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513833"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513833"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513833; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513833]").text(description); $(".js-view-count[data-work-id=65513833]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513833; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513833']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513833, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513833]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513833,"title":"Subject Preferences and Psychological Implications of Portable Oxygen Concentrator Versus Compressed Oxygen Cylinder in Chronic Lung Disease","translated_title":"","metadata":{"abstract":"BACKGROUND: Oxygen therapy represents the elective therapy to improve the quality of life for patients with chronic respiratory diseases like COPD and interstitial lung disease. Lightweight portable oxygen concentrators (POCs) are a valid alternative to traditional systems such as portable compressed oxygen cylinders. However, patient preference and the possible psychological implications related to the use of both devices have been poorly assessed. We sought to evaluate patient preference between the ambulatory oxygen systems (ie, a POC or a small cylinder) for patients with COPD and interstitial lung disease experiencing exertional desaturation in a rehabilitation setting. Furthermore, the use of one device in comparison with the other was related to specific mechanical characteristics and related to perceived quality of life, anxiety, and depressive symptoms. METHODS: 30 subjects with COPD and interstitial lung disease, who demonstrated exertional desaturation on room air during ...","publisher":"Respiratory Care","publication_date":{"day":null,"month":null,"year":2020,"errors":{}}},"translated_abstract":"BACKGROUND: Oxygen therapy represents the elective therapy to improve the quality of life for patients with chronic respiratory diseases like COPD and interstitial lung disease. Lightweight portable oxygen concentrators (POCs) are a valid alternative to traditional systems such as portable compressed oxygen cylinders. However, patient preference and the possible psychological implications related to the use of both devices have been poorly assessed. We sought to evaluate patient preference between the ambulatory oxygen systems (ie, a POC or a small cylinder) for patients with COPD and interstitial lung disease experiencing exertional desaturation in a rehabilitation setting. Furthermore, the use of one device in comparison with the other was related to specific mechanical characteristics and related to perceived quality of life, anxiety, and depressive symptoms. METHODS: 30 subjects with COPD and interstitial lung disease, who demonstrated exertional desaturation on room air during ...","internal_url":"https://www.academia.edu/65513833/Subject_Preferences_and_Psychological_Implications_of_Portable_Oxygen_Concentrator_Versus_Compressed_Oxygen_Cylinder_in_Chronic_Lung_Disease","translated_internal_url":"","created_at":"2021-12-22T07:42:43.281-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Subject_Preferences_and_Psychological_Implications_of_Portable_Oxygen_Concentrator_Versus_Compressed_Oxygen_Cylinder_in_Chronic_Lung_Disease","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513832"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513832/Performance_of_fractional_exhaled_nitric_oxide_in_predicting_response_to_inhaled_corticosteroids_in_chronic_cough_a_meta_analysis"><img alt="Research paper thumbnail of Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513832/Performance_of_fractional_exhaled_nitric_oxide_in_predicting_response_to_inhaled_corticosteroids_in_chronic_cough_a_meta_analysis">Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis</a></div><div class="wp-workCard_item"><span>Annals of Medicine</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract Background. Chronic cough is a disabling condition with a high proportion of diagnostic ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract Background. Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) has been considered a useful biomarker for predicting inhaled corticosteroids (ICS) response. We evaluated the relationship between FeNO and ICS response in chronic cough by performing a systematic review with meta-analysis. Methods. PubMed, Web of Science, Scopus and EMBASE databases were systematically searched. Differences were expressed as Odds Ratio (OR) with 95% confidence intervals (95%CI). Pooled sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), and area under the hierarchical summary receiver operating characteristic curve (HSROCAUC) were estimated. Results. Nine articles on 740 chronic-cough patients showed that the response rate to ICS was 87.4% (95%CI: 83.8–91.0) in 317 patients with a high FeNO and 46.3% (95%CI: 41.6–51.0) in 423 controls, with an attributable proportion of 47.0% and a diagnostic OR of 9.1 (95%CI: 3.7–22.4, p &lt; .001). The pooled estimate of diagnostic indexes resulted in a sensitivity of 68.5% (95%CI: 46.7–84.4) and specificity of 81.9% (95%CI: 63.0–92.3), with a HSROCAUC of 0.82 (95%CI: 0.64–0.90). In a realistic scenario with a pre-test probability set at 30%, based on a pooled PLR of 3.79 (95%CI: 1.24–7.47) and NLR of 0.38 (95%CI: 0.22–0.66), the post-test probability was 62% with a high FeNO and 14% if the test was negative. Subgroup analyses confirmed a better performance for the recommended FeNO cut-off greater than 25 ppb. Meta-regression and sensitivity analyses showed no impact of major demographic and clinic variables on results. Conclusions. A high FeNO before starting ICS therapy may help identify chronic-cough patients responding to treatment, with a better performance ofhigher cut-off values. Further studies are needed to evaluate the real usefulness of this biomarker to guide cough therapy and optimise strategies in different healthcare settings (community, hospital, rehabilitation). Key messages Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) may be a useful biomarker for identifying chronic cough patients who respond to steroid treatment. A FeNO cut-off lower than 25 ppb should be considered irrelevant for this clinical application.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513832"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513832"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513832; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513832]").text(description); $(".js-view-count[data-work-id=65513832]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513832; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513832']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513832, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513832]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513832,"title":"Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis","translated_title":"","metadata":{"abstract":"Abstract Background. Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) has been considered a useful biomarker for predicting inhaled corticosteroids (ICS) response. We evaluated the relationship between FeNO and ICS response in chronic cough by performing a systematic review with meta-analysis. Methods. PubMed, Web of Science, Scopus and EMBASE databases were systematically searched. Differences were expressed as Odds Ratio (OR) with 95% confidence intervals (95%CI). Pooled sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), and area under the hierarchical summary receiver operating characteristic curve (HSROCAUC) were estimated. Results. Nine articles on 740 chronic-cough patients showed that the response rate to ICS was 87.4% (95%CI: 83.8–91.0) in 317 patients with a high FeNO and 46.3% (95%CI: 41.6–51.0) in 423 controls, with an attributable proportion of 47.0% and a diagnostic OR of 9.1 (95%CI: 3.7–22.4, p \u0026lt; .001). The pooled estimate of diagnostic indexes resulted in a sensitivity of 68.5% (95%CI: 46.7–84.4) and specificity of 81.9% (95%CI: 63.0–92.3), with a HSROCAUC of 0.82 (95%CI: 0.64–0.90). In a realistic scenario with a pre-test probability set at 30%, based on a pooled PLR of 3.79 (95%CI: 1.24–7.47) and NLR of 0.38 (95%CI: 0.22–0.66), the post-test probability was 62% with a high FeNO and 14% if the test was negative. Subgroup analyses confirmed a better performance for the recommended FeNO cut-off greater than 25 ppb. Meta-regression and sensitivity analyses showed no impact of major demographic and clinic variables on results. Conclusions. A high FeNO before starting ICS therapy may help identify chronic-cough patients responding to treatment, with a better performance ofhigher cut-off values. Further studies are needed to evaluate the real usefulness of this biomarker to guide cough therapy and optimise strategies in different healthcare settings (community, hospital, rehabilitation). Key messages Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) may be a useful biomarker for identifying chronic cough patients who respond to steroid treatment. A FeNO cut-off lower than 25 ppb should be considered irrelevant for this clinical application.","publisher":"Informa UK Limited","publication_name":"Annals of Medicine"},"translated_abstract":"Abstract Background. Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) has been considered a useful biomarker for predicting inhaled corticosteroids (ICS) response. We evaluated the relationship between FeNO and ICS response in chronic cough by performing a systematic review with meta-analysis. Methods. PubMed, Web of Science, Scopus and EMBASE databases were systematically searched. Differences were expressed as Odds Ratio (OR) with 95% confidence intervals (95%CI). Pooled sensitivity, specificity, positive (PLR) and negative likelihood ratio (NLR), and area under the hierarchical summary receiver operating characteristic curve (HSROCAUC) were estimated. Results. Nine articles on 740 chronic-cough patients showed that the response rate to ICS was 87.4% (95%CI: 83.8–91.0) in 317 patients with a high FeNO and 46.3% (95%CI: 41.6–51.0) in 423 controls, with an attributable proportion of 47.0% and a diagnostic OR of 9.1 (95%CI: 3.7–22.4, p \u0026lt; .001). The pooled estimate of diagnostic indexes resulted in a sensitivity of 68.5% (95%CI: 46.7–84.4) and specificity of 81.9% (95%CI: 63.0–92.3), with a HSROCAUC of 0.82 (95%CI: 0.64–0.90). In a realistic scenario with a pre-test probability set at 30%, based on a pooled PLR of 3.79 (95%CI: 1.24–7.47) and NLR of 0.38 (95%CI: 0.22–0.66), the post-test probability was 62% with a high FeNO and 14% if the test was negative. Subgroup analyses confirmed a better performance for the recommended FeNO cut-off greater than 25 ppb. Meta-regression and sensitivity analyses showed no impact of major demographic and clinic variables on results. Conclusions. A high FeNO before starting ICS therapy may help identify chronic-cough patients responding to treatment, with a better performance ofhigher cut-off values. Further studies are needed to evaluate the real usefulness of this biomarker to guide cough therapy and optimise strategies in different healthcare settings (community, hospital, rehabilitation). Key messages Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) may be a useful biomarker for identifying chronic cough patients who respond to steroid treatment. A FeNO cut-off lower than 25 ppb should be considered irrelevant for this clinical application.","internal_url":"https://www.academia.edu/65513832/Performance_of_fractional_exhaled_nitric_oxide_in_predicting_response_to_inhaled_corticosteroids_in_chronic_cough_a_meta_analysis","translated_internal_url":"","created_at":"2021-12-22T07:42:43.125-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":59702603,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Performance_of_fractional_exhaled_nitric_oxide_in_predicting_response_to_inhaled_corticosteroids_in_chronic_cough_a_meta_analysis","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":59702603,"first_name":"Salvatore","middle_initials":null,"last_name":"Fuschillo","page_name":"SalvatoreFuschillo","domain_name":"independent","created_at":"2017-02-05T23:18:32.088-08:00","display_name":"Salvatore Fuschillo","url":"https://independent.academia.edu/SalvatoreFuschillo"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":15536792,"url":"https://www.tandfonline.com/doi/pdf/10.1080/07853890.2021.1979242"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65513641"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65513641/Comparison_of_three_different_exhaled_nitric_oxide_analyzers_in_chronic_respiratory_disorders"><img alt="Research paper thumbnail of Comparison of three different exhaled nitric oxide analyzers in chronic respiratory disorders" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65513641/Comparison_of_three_different_exhaled_nitric_oxide_analyzers_in_chronic_respiratory_disorders">Comparison of three different exhaled nitric oxide analyzers in chronic respiratory disorders</a></div><div class="wp-workCard_item"><span>Journal of Breath Research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BACKGROUND Fractional exhaled nitric oxide (FeNO) measurement is a simple and non-invasive method...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BACKGROUND Fractional exhaled nitric oxide (FeNO) measurement is a simple and non-invasive method for monitoring eosinophilic airway inflammation. New portable analyzers for FeNO measurements are constantly being developed. The aim of our study was to evaluate the agreement of FeNO values measured by new portable analyzers. MATERIALS AND METHODS FeNO was measured in 20 healthy subjects, 20 asthmatic and 20 chronic obstructive pulmonary disease patients using the analyzers Niox-VERO, Vivatmo-PRO and HypAir-FeNO. A linear relationship was estimated with Pearson&#39;s coefficient (r), and absolute agreement by the intraclass correlation coefficient (ICC) and bias with the limits of agreement (95% of paired differences) were assessed according to the Bland-Altman method. RESULTS In the study population (58 ± 14 years, 20 females), mean values of FeNO with their 95% confidence interval were 24.0 (18.6-29.4) with the Niox-VERO, 19.6 (13.6-25.7) with the Vivatmo-PRO and 20.4 (15.7-25.1) with the HypAir-FeNO. FeNO measured with the Niox-VERO was higher than the Vivatmo-PRO (mean difference of paired values +4.3; limits -16.0 to 25.7 ppb) and the HypAir-FeNO (+3.6; -12.2 to 19.4 ppb); the Vivatmo-PRO and HypAir-FeNO showed large variability of paired differences (-0.7; -16.5 to 15.0 ppb). Measurements linearly correlated with an imperfect absolute agreement: Niox-VERO versus Vivatmo-PRO r = 0.90 and ICC = 0.87; Niox-VERO versus HypAir-FeNO r = 0.93 and ICC = 0.90, Vivatmo-PRO versus HypAir-FeNO r = 0.96 and ICC = 0.93. Most of the disagreement was greater in some asthmatic patients at high values of FeNO. CONCLUSIONS The present study indicates that absolute exhaled NO measurements may differ to a clinically relevant extent using the Niox-VERO, Vivatmo-PRO and HypAir-FeNO analyzers. The devices cannot be used interchangeably.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65513641"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65513641"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65513641; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65513641]").text(description); $(".js-view-count[data-work-id=65513641]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65513641; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65513641']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65513641, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65513641]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65513641,"title":"Comparison of three different exhaled nitric oxide analyzers in chronic respiratory disorders","translated_title":"","metadata":{"abstract":"BACKGROUND Fractional exhaled nitric oxide (FeNO) measurement is a simple and non-invasive method for monitoring eosinophilic airway inflammation. New portable analyzers for FeNO measurements are constantly being developed. The aim of our study was to evaluate the agreement of FeNO values measured by new portable analyzers. MATERIALS AND METHODS FeNO was measured in 20 healthy subjects, 20 asthmatic and 20 chronic obstructive pulmonary disease patients using the analyzers Niox-VERO, Vivatmo-PRO and HypAir-FeNO. A linear relationship was estimated with Pearson\u0026#39;s coefficient (r), and absolute agreement by the intraclass correlation coefficient (ICC) and bias with the limits of agreement (95% of paired differences) were assessed according to the Bland-Altman method. RESULTS In the study population (58 ± 14 years, 20 females), mean values of FeNO with their 95% confidence interval were 24.0 (18.6-29.4) with the Niox-VERO, 19.6 (13.6-25.7) with the Vivatmo-PRO and 20.4 (15.7-25.1) with the HypAir-FeNO. FeNO measured with the Niox-VERO was higher than the Vivatmo-PRO (mean difference of paired values +4.3; limits -16.0 to 25.7 ppb) and the HypAir-FeNO (+3.6; -12.2 to 19.4 ppb); the Vivatmo-PRO and HypAir-FeNO showed large variability of paired differences (-0.7; -16.5 to 15.0 ppb). Measurements linearly correlated with an imperfect absolute agreement: Niox-VERO versus Vivatmo-PRO r = 0.90 and ICC = 0.87; Niox-VERO versus HypAir-FeNO r = 0.93 and ICC = 0.90, Vivatmo-PRO versus HypAir-FeNO r = 0.96 and ICC = 0.93. Most of the disagreement was greater in some asthmatic patients at high values of FeNO. CONCLUSIONS The present study indicates that absolute exhaled NO measurements may differ to a clinically relevant extent using the Niox-VERO, Vivatmo-PRO and HypAir-FeNO analyzers. The devices cannot be used interchangeably.","publisher":"IOP Publishing","publication_name":"Journal of Breath Research"},"translated_abstract":"BACKGROUND Fractional exhaled nitric oxide (FeNO) measurement is a simple and non-invasive method for monitoring eosinophilic airway inflammation. New portable analyzers for FeNO measurements are constantly being developed. The aim of our study was to evaluate the agreement of FeNO values measured by new portable analyzers. MATERIALS AND METHODS FeNO was measured in 20 healthy subjects, 20 asthmatic and 20 chronic obstructive pulmonary disease patients using the analyzers Niox-VERO, Vivatmo-PRO and HypAir-FeNO. A linear relationship was estimated with Pearson\u0026#39;s coefficient (r), and absolute agreement by the intraclass correlation coefficient (ICC) and bias with the limits of agreement (95% of paired differences) were assessed according to the Bland-Altman method. RESULTS In the study population (58 ± 14 years, 20 females), mean values of FeNO with their 95% confidence interval were 24.0 (18.6-29.4) with the Niox-VERO, 19.6 (13.6-25.7) with the Vivatmo-PRO and 20.4 (15.7-25.1) with the HypAir-FeNO. FeNO measured with the Niox-VERO was higher than the Vivatmo-PRO (mean difference of paired values +4.3; limits -16.0 to 25.7 ppb) and the HypAir-FeNO (+3.6; -12.2 to 19.4 ppb); the Vivatmo-PRO and HypAir-FeNO showed large variability of paired differences (-0.7; -16.5 to 15.0 ppb). Measurements linearly correlated with an imperfect absolute agreement: Niox-VERO versus Vivatmo-PRO r = 0.90 and ICC = 0.87; Niox-VERO versus HypAir-FeNO r = 0.93 and ICC = 0.90, Vivatmo-PRO versus HypAir-FeNO r = 0.96 and ICC = 0.93. Most of the disagreement was greater in some asthmatic patients at high values of FeNO. CONCLUSIONS The present study indicates that absolute exhaled NO measurements may differ to a clinically relevant extent using the Niox-VERO, Vivatmo-PRO and HypAir-FeNO analyzers. 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