Prion Biology

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valign="top"> <table cellpadding="0" cellspacing="0" border="0" width="100%"> </td></tr>  <SCRIPT LANGUAGE = "JavaScript">  </SCRIPT>     <form id="addme" name="addme" method="post" action="checkout.tpl"> <input type="hidden" name="action" value="Add"> <input type="hidden" name="cart" value="17324354022333379618"> <input type="hidden" name="sku" value="1098"> <input type="hidden" name="typ" value="ps">   <tr> <td colspan=4 rowspan=3 align=left valign=top style="padding-right:15px;"><font face="[Font[__TEXT_FONT_INDEX]]" size=-2><a href="image.tpl?img=PrionBiology_f.jpg&pagetitle=CSHLP America - Cover image - Prion Biology " target="_help"><img src="productgraphics/big/PrionBiology_f.jpg" border="1" width="220"></a>   <br><p style="text-align:center;"><a href="image.tpl?img=PrionBiology_f.jpg" target="_help">Click to Enlarge</a></p> </td> <td colspan=3 rowspan="2" valign="top" > <h4 style="color:black;">Prion Biology</h4> <br><font face="[Font[__TEXT_FONT_INDEX]]" size="-1"><font color="#777777"><b>Subject Area(s):</b></font>  <A HREF="default.tpl?cart=17324354022333379618&id1=24&startat=1&--woSECTIONSdatarq=24&--SECTIONSword=ww&--Publication_Yearsort=1&--Sequence_numbersort=2&--Publication_yearsdir=de&--Sequence_numbersdir=de">Cell Biology</A>; <A HREF="default.tpl?cart=17324354022333379618&id1=105&startat=1&--woSECTIONSdatarq=105&--SECTIONSword=ww&--Publication_Yearsort=1&--Sequence_numbersort=2&--Publication_yearsdir=de&--Sequence_numbersdir=de">Proteins and Proteomics</A>; <A HREF="default.tpl?cart=17324354022333379618&id1=100&startat=1&--woSECTIONSdatarq=100&--SECTIONSword=ww&--Publication_Yearsort=1&--Sequence_numbersort=2&--Publication_yearsdir=de&--Sequence_numbersdir=de">Human Biology and Disease</A><br> <br><font face="[Font[__TEXT_FONT_INDEX]]" size=-1>Edited by Stanley B. Prusiner, <font face="[Font[__TEXT_FONT_INDEX]]" size=-1><em>University of California, San Francisco</em> <p><font face="[Font[__TEXT_FONT_INDEX]]" size="-1"><strong><p style="margin-bottom:.3em;">Download a Free Excerpt from <em>Prion Biology</em>:</p> <p style="margin-top:.3em; font-weight:normal;"><a href="pdf/sample/2017/prionbio/PrionBioPreface.pdf" target="_blank">Preface</a><br> <a href="pdf/sample/2017/prionbio/PrionBioChap.pdf" target="_blank">Functional Prions in the Brain</a><br> <a href="pdf/sample/2017/prionbio/PrionBioIndex.pdf" target="_blank">Index</a></p></strong></p> </td> </tr> <tr> </tr> <tr>  <td colspan="4" valign="top"> <br> <font face="[Font[__TEXT_FONT_INDEX]]" size="-1"><p>© 2017  456 pages, illustrated (74 color and 16 B&W), index<br> <font face="[Font[__TEXT_FONT_INDEX]]" size="-1"> <font face="[Font[__TEXT_FONT_INDEX]]" size="-1">Hardcover  <font face="[Font[__TEXT_FONT_INDEX]]" size="-1">    <strong><strike>$135</strike></strong> <strong><font color=red>108.00</font></strong> <br>ISBN  <font face="[Font[__TEXT_FONT_INDEX]]" size="-1">978-1-621820-93-2 <br>You save: <span style="color:red;font-weight:bold;">20%</span> <br>You will receive <span style="color:red;font-weight:bold;">free shipping</span> on this item at checkout. <br><span style="font-size:85%;">Free shipping offer applies to direct website purchases by individual U.S. customers only.</span> <br> <br>      <input type="hidden" name="the_price" value="108"> </form> <style> td.etab { padding-right:30px; } td.itab { padding-left:25px; } tr.alltab td { border-bottom:1pt solid #dedede; padding-bottom:15px; } </style> <table style="border:1px solid #dedede;padding-top:8px;padding-bottom:8px;padding-left:15px;padding-right:15px;" >    <form name="addme1" method="post" action="checkout.tpl"> <input type="hidden" name="action" value="Add"> <input type="hidden" name="cart" value="17324354022333379618"> <input type="hidden" name="sku" value="1197"> <input type="hidden" name="__8" value="+1195+"> <input type="hidden" name="the_price" value="135"> <tr class="alltab"><td class="etab">Print Book + eBook<br>     <span style="font-size:90%;font-style:italic;">Best value!</span></td><td><strong> <strike>$210</strike> <font color=red>$135.00</font> </strong></td> <td class="itab"><a href="javascript:document.addme1.submit()"><img src="images/atc_ep.jpg" alt="Add To Cart" border="0"></a></td></tr> </form> <form id="addme" name="addme0" method="post" action="checkout.tpl"><tr class="alltab"><td class="etab">Print Book</td><td><strong><strike>$135</strike></strong> <strong><font color=red>$108.00</font></strong></td> <td class="itab"><a href="javascript:document.addme0.submit()"><img src="images/atc_po.jpg" alt="Add To Cart" border="0"></a></td></tr> <input type="hidden" name="action" value="Add"> <input type="hidden" name="cart" value="17324354022333379618"> <input type="hidden" name="sku" value="1098"> <input type="hidden" name="the_price" value="108"> </form>   <form name="addme2" method="post" action="checkout.tpl"> <input type="hidden" name="action" value="Add"> <input type="hidden" name="cart" value="17324354022333379618"> <input type="hidden" name="sku" value="1195"> <input type="hidden" name="__8" value=""> <input type="hidden" name="the_price" value="75"> </form> <form name="addme3" method="post" action="checkout.tpl"> <input type="hidden" name="action" value="Add"> <input type="hidden" name="cart" value="17324354022333379618"> <input type="hidden" name="sku" value="1195"> <input type="hidden" name="the_price" value="75"> <tr><td class="etab">eBook</td><td><strong>$75.00</strong></td> <td class="itab"><a href="javascript:document.addme3.submit()"><img src="images/atc_eo.jpg" alt="Add To Cart" border="0"></a></td></tr> </form> </table> <p style="margin-left:6px;margin-top:10px;font-weight:normal;">Bulk discounts available for your lab or class. <a href="/cdn-cgi/l/email-protection#4221312a2e32302731310221312a2e6c2726377d113720282721367f00372e2967707227002d2d296770722b2c33372b303b67707273727b7a" target="_top" ">Click here to inquire</a>.</p> <p style="font-size:85%;margin-left:6px;margin-top:10px;font-weight:bold;">eBooks use Adobe Digital Editions software. <a href="ebook_howto.tpl?cart=17324354022333379618" target="_blank">Click here</a> for more information.</p> </p>  </td> </tr> <tr> <td></td><td></td><td colspan=4> </td></tr> <tr><td colspan=6 align=left><font face="[Font[__TEXT_FONT_INDEX]]" size="-1"> <div class="section_tabs"> <ul class="tabs_bk">  <li class="current">     Description     </li> <li>     Contents     </li> <li>     Reviews     </li> <li>     Related Titles     </li> </ul> <div class="box visible"> <A name="description"><h4>Description</h4></a> <p>Prions are best known as the infectious proteins causing mad cow and related diseases, and a growing number of proteins with similar properties are implicated in disorders such as Alzheimers and Parkinsons. But some recently discovered prion proteins do not seem to induce pathological changes and, in fact, may function in basic biological processes such as transcription, immune regulation, and memory formation.</p> <p>Written and edited by experts in the field, this collection from <em>Cold Spring Harbor Perspectives in Biology</em> examines the expanding roles of prions in health and disease. The contributors review the structures of prion proteins and how they adopt alternative structures and aggregate into amyloid fibrils and other insoluble complexes. The alternatively folded prion forms display unique biological properties. Although some prion proteins feature in cellular dysfunction, others have normal physiological roles (e.g., CPEB in the brain and MAVS in the immune response). This volume is an essential reference for biochemists, cell and molecular biologists, and all who wish to understand how prions are formed from alternatively folded, self-propagating proteins.</p> </div> <div class="box"><h4>Contents</h4></A> <dl> <dt style="padding-top:6px;">Preface</dt> <dt style="padding-top:12px;">INTRODUCTION</dt> <dt style="padding-top:6px;">An Introduction to Prion Biology</dt> <dd><em>Stanley B. Prusiner</em></dd> <dt style="padding-top:6px;">The Amyloid Phenomenon and Its Links with Human Disease</dt> <dd><em>Christopher M. Dobson</em></dd> <dt style="padding-top:6px;">Toward the Atomic Structure of PrPSc</dt> <dd><em>Jose A. Rodriguez, Lin Jiang, and David S. Eisenberg</em></dd> <dt style="padding-top:6px;">The Three-Dimensional Structures of Amyloids</dt> <dd><em>Roland Riek</em></dd> <dt style="padding-top:6px;">Protein Quality Control in Health and Disease</dt> <dd><em>Tatyana Dubnikov, Tziona Ben-Gedalya, and Ehud Cohen</em></dd> <dt style="padding-top:12px;">FUNGAL PRIONS</dt> <dt style="padding-top:6px;">Yeast and Fungal Prions</dt> <dd><em>Reed B. Wickner</em></dd> <dt style="padding-top:6px;">The HET-S/s Prion Motif in the Control of Programmed Cell Death</dt> <dd><em>Roland Riek and Sven J. Saupe</em></dd> <dt style="padding-top:6px;">Prions, Chaperones, and Proteostasis in Yeast</dt> <dd><em>Tatiana A. Chernova, Keith D. Wilkinson, and Yury O. Chernoff</em></dd> <dt style="padding-top:12px;">NONPATHOGENIC MAMMALIAN PRIONS</dt> <dt style="padding-top:6px;">Functional Prions in the Brain</dt> <dd><em>Joseph B. Rayman and Eric R. Kandel</em></dd> <dt style="padding-top:6px;">Prion-Like Polymerization in Immunity and Inflammation</dt> <dd><em>Xin Cai, Hui Xu, and Zhijian J. Chen</em></dd> <dt style="padding-top:6px;">TIA-1 Is a Functional Prion-Like Protein</dt> <dd><em>Joseph B. Rayman and Eric R. Kandel</em></dd> <dt style="padding-top:6px;">Cross-β Polymerization of Low Complexity Sequence Domains</dt> <dd><em>Masato Kato and Steven L. McKnight</em></dd> <dt style="padding-top:12px;">OVERVIEW OF THE PRION DISEASES</dt> <dt style="padding-top:6px;">Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases</dt> <dd><em>Michael G. Erkkinen, Mee-Ohk Kim, and Michael D. Geschwind</em></dd> <dt style="padding-top:6px;">Molecular Genetics of Neurodegenerative Dementias</dt> <dd><em>Flora I. Hinz and Daniel H. Geschwind</em></dd> <dt style="padding-top:6px;">Genetic PrP Prion Diseases</dt> <dd><em>Mee-Ohk Kim, Leonel T. Takada, Katherine Wong, Sven A. Forner, and 鈥∕ichael D. Geschwind</em></dd> <dt style="padding-top:6px;">Prion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential Therapy</dt> <dd><em>Caroline Sibilla and Anne Bertolotti</em></dd> <dt style="padding-top:6px;">Neurodegenerative Disease Transmission and Transgenesis in Mice</dt> <dd><em>Brittany N. Dugger, Daniel P. Perl, and George A. Carlson</em></dd> <dt style="padding-top:6px;">Mapping Neurodegenerative Disease Onset and Progression</dt> <dd><em>William W. Seeley</em></dd> <dt style="padding-top:6px;">Tau Positron Emission Tomography Imaging</dt> <dd><em>Hartmuth C. Kolb and José Ignacio Andrés</em></dd> <dt style="padding-top:6px;">Pathology of Neurodegenerative Diseases</dt> <dd><em>Brittany N. Dugger and Dennis W. Dickson</em></dd> <dt style="padding-top:6px;">Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimers and Parkinsons Diseases</dt> <dd><em>Heiko Braak and Kelly Del Tredici</em></dd> <dt style="padding-top:6px;">Bioassays and Inactivation of Prions</dt> <dd><em>Kurt Giles, Amanda L. Woerman, David B. Berry, and Stanley B. Prusiner</em></dd> <dt style="padding-top:6px;">Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?</dt> <dd><em>Danielly C.F. Costa, Guilherme A.P. de Oliveira, Elio A. Cino, Iaci N. Soares, Luciana P. Rangel, and Jerson L. Silva</em></dd> <dt style="padding-top:6px;">Glossary</dt> <dt style="padding-top:6px;">Index</dt> </dl> </div> <div class="box"><A name="reviews"><h4>Reviews</h4></A> <p><img src="eye1.gif" width="30" height="30" border="0" alt="review:">  “Will the articles in this volume be accessible and of interest to those not directly working in prion research or related fields? Again the answer is yes. The editor provides both a very accessible introductory chapter and, importantly, a glossary of the key terms. This will ensure that general readers can navigate the various topics covered in this book and fully appreciate the impact prion research will continue to have on our understanding of major diseases and human and fungal biology.” <br>       <i>Quarterly Review of Biology</i></p> </div> <div class="box"><A name="relateds"><h4>Related Titles</h4></A>  <br><font face="[Font[__TEXT_FONT_INDEX]]" size="-1"><a href="default.tpl?action=full&cart=17324354022333379618&--eqskudatarq=1177"></a> [<em></em>]<br> <br><font face="[Font[__TEXT_FONT_INDEX]]" size="-1"><a href="default.tpl?action=full&cart=17324354022333379618&--eqskudatarq=1176">Prion Diseases</a> [<em>Paperback</em>]<br> </div> </div> <tr> <td colspan="2" align="center"><font face="[Font[__TEXT_FONT_INDEX]]" size="-1"> </td> </tr> </table> <TABLE cellpadding="0" cellspacing="0" border="0" width="100%"> <TR> <TD align="right" width="40%">  </TD> <td width="2%"><font face="[Font[__TEXT_FONT_INDEX]]" 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Prion Biology