Center for Tissue Regeneration and Repair

<!DOCTYPE html> <html lang="en"> <head> <meta http-equiv="content-type" content="text/html;charset=UTF-8"/> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1.0,minimum-scale=1.0"> <title>Center for Tissue Regeneration and Repair</title> <META NAME='last-modified' CONTENT='20161227'/> <meta name="copyright" content="Copyright UC Regents. For more information regarding the University of California's copyright terms, visit https://www.ucop.edu/services/terms.html"> <meta name="author" content="UC Davis Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair"/> <meta name="keywords" content="morphogenesis, morphogenetic, bone, skeleton, cloning, UC, Davis, health, system, center, tissue, regeneration, repair, medical, center "/> <meta name="description" content="Regenerative medicine focuses on design and manufacture of spare parts for the human body to restore function of lost parts due to cancer, diseases and trauma. "/>  <link href="/global/design/responsive/bootstrap/css/bootstrap.min.css?v=4" rel="stylesheet" type="text/css" > <link href="/global/design/responsive/bootstrap/css/customnavbar.css?v=4" rel="stylesheet" type="text/css" > <link href="/global/design/responsive/global.css?v=5" rel="stylesheet" type="text/css" > <link rel="stylesheet" type="text/css" href="/global/design/responsive/bootstrap/css/navtoptitle.css?v=4"> <link href="/global/design/responsive/theme/fullwidth-layout/fullwidth-home-styles.css?v=4" rel="stylesheet" type="text/css" >    <script type="text/javascript" src="/global/design/responsive/lib/jquery/jquery-1.11.1.min.js?v=4"></script> <script type="text/javascript" src="/global/design/responsive/bootstrap/js/bootstrap.min.js?v=4"></script> <script type="text/javascript" src="/global/design/responsive/bootstrap/js/bootstrap-hover-dropdown.min.js?v=4"></script>  <script src="/global/design/responsive/global.js?v=4"></script> <link rel="stylesheet" href="/global/design/responsive/utility/autocomplete/jquery-ui-1.10.4.custom.css?v=4"> <script src="/global/design/responsive/utility/autocomplete/jquery-ui-1.10.4.custom.js?v=4"></script> <script src="/global/design/responsive/utility/global-alert/alert.js?v=4"></script>  <script async src="https://cse.google.com/cse.js?cx=b7ab097b6fba8dacb"></script> <link rel="icon" href="/assets/images/icons/favicon/favicon.ico" sizes="any"> <link rel="icon" href="/assets/images/icons/favicon/favicon.svg" type="image/svg+xml"> <link rel="apple-touch-icon" href="/assets/images/icons/favicon/apple-touch-icon.png">  <link href="/global/design/responsive/utility/flexslider/flexslider.css?v=2" rel="stylesheet" type="text/css" > <script type="text/javascript" src="/global/design/responsive/utility/flexslider/jquery.flexslider.min.js?v=2"></script>    </head> <body> <div class="container shadow" id="header"> <header> <div class="navskip"><a href="#content" class="sr-only" title="Skip to main content" >Skip to main content</a></div> <a class="wordmark" href="/welcome/"><img src="/global/images/wordmarks/UCDavisHealth.svg" alt="Center for Tissue Regeneration and Repair"></a> <div class="title"><a href="/ctrr" title="Center for Tissue Regeneration and Repair">Center for Tissue Regeneration and Repair</a></div> <div id="mini_navbar"><a href="https://health.ucdavis.edu/newsroom/">News</a> | <a href="https://hr.ucdavis.edu/">Careers</a> | <a href="https://health.ucdavis.edu/giving/">Giving</a> | <a href="https://health.ucdavis.edu/welcome/"><span class="hide-mobile">UC Davis </span>Health</a> </div>  <div id="search" style="width: 250px;" class="main_search form-inline" id="searchpageform"> <div class="gcse-searchbox-only" enableAutoComplete="true" data-resultsUrl="/search/" data-newWindow="false"> </div> </div>  </header> </div>   <div class="container shadow" id="main">  <div class="navbar-wrapper"> <div class="navtop">  <nav class="navbar navbar-default" role="navigation" aria-label="Main menu"> <div class="navbar-header"> <button type="button" class="navbar-toggle" data-toggle="collapse" data-target=".navbar-collapse"> <span class="sr-only">Toggle navigation</span> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> </button> <a href="/ctrr/" class="navbar-brand">Center for Tissue Regeneration and Repair</a> </div> <div class="collapse navbar-collapse"> <ul class="nav navbar-nav navbar-left" role="menubar"> <li class="dropdown" role="menuitem"> <a href="*" class="dropdown-toggle" data-toggle="dropdown" data-hover="dropdown">Research<b class="caret" style="margin-left:5px"></b></a> <ul class="dropdown-menu" role="menu"> <li role="menuitem"> <a href="/ctrr/education/morphogenesis.html" >Morphogenesis and Morphogenetic Proteins for Articular Cartilage Regeneration</a> </li> <li role="menuitem"> <a href="/ctrr/education/index.html" >Bone Morphogenetic Protein Family </a> </li> <li role="menuitem"> <a href="/ctrr/education/interleukin.html" >Interleukin-17 Family</a> </li> </ul> </li> <li> <a href="/ctrr/ourteam/index.html">Our Team</a> </li> <li> <a href="/ctrr/contactus/index.html">Contact Us</a> </li> </ul> </div> </nav>  </div> </div>  <div id="topbanner">  <div class="flexslider"> <ul class="slides single"> <li> <div class="slide"> <a href="/ctrr/ourteam/index.html"> <img alt="Dr. Reddi" src="/ctrr/images/ORTHOPAEDICS REDDI _Lo_Res.jpg" /> </a> </div> <div class="slide-caption"> <a href="/ctrr/ourteam/index.html"> <h1>UC Davis Center for Tissue Regeneration and Repair</h1> <h2></h2> </a> </div> </li> </ul> </div>   </div>  <section>  <div class="row" id="row1cols"> <div class="col-66percent maincol" id="content">    <div class="page-header"> <h1> Welcome to the UC Davis Center for Tissue Regeneration and Repair</h1> </div>    <div class="panel panel-plain"> <div class="panel-body"> <p>Regenerative medicine and surgery are emerging areas of medicine that are based on design and development of spare parts for the human body. The UC Davis Center for Tissue Regeneration and Repair focuses on regeneration for the musculoskeletal system to restore function to tissue diseased or damaged from cancer, trauma, and arthritis. Regenerative medicine is based on principles of molecular developmental biology and is governed by basic biomechanics and bioengineering. The three key elements of regenerative medicine and tissue engineering are morphogenetic signals, stem cells, and scaffolds of extracellular matrix. Regeneration recapitulates embryonic development and morphogenesis.</p> <p>Tissue engineering and regeneration of bone and articular cartilage are the top priorities in the research conducted at the Center. This is being addressed through multiple biological and biomechanical approaches. Superficial zone protein is produced by the top layer or articular cartilage and serves as a boundary lubricant, reducing friction.</p> <p>One segment of the lab is analyzing the relationship between friction and wear of articular cartilage due to changes in mechanical loading, SZP expression, and the greater biomechanical environment. Previous work by this lab has shown that SZP is produced by loading-bearing regions of articular cartilage. We continue to study the biomechanical regulations of SZP by examining its expression in response to a variety of mechanical loading regimes. The mechanotransduction of SZP is also being studied at the cellular level, in relation to cell shape and cytoskeletal morphology. In recent years, the lab has identified stem and progenitor cells in articular cartilage, muscle and synovial tissues. Building upon this work we are exploring the differentiation of embryonic and adult stem cells for articular cartilage and bone repair.</p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> </div> </div>  </div>  <div class="col-33percent sidebar">   <div class="panel panel-default"> <div class="panel-heading"> <h3 class="panel-title">Researchers</h3> </div> <div class="panel-body"> <p><a href="/ctrr/research/reddi.html">A. Hari Reddi, Ph.D.</a></p> <p><a href="/ctrr/research/lo.html">Su Hao Lo, Ph.D.</a></p> </div> </div>   </div> </div>  </section>    </div>  <div class="container shadow" id="footer"> <footer>  <div class="row" id="row2cols3"> <div class="col-33percent-sm"> <h5> Quick Links </h5> <ul class="list"> <li><a href="/newsroom/socialmedia/">Social Media</a></li> <li><a href="http://www.ucdavis.edu/search/">Faculty and Staff Directory</a></li> <li><a href="/newsroom/">UC Davis Health Newsroom</a></li> <li><a href="https://www.ucdavis.edu/" rel="noopener" target="_blank">UC Davis</a></li> </ul> </div> <div class="col-33percent-sm"> <h5> UC Davis Health Encompasses </h5> <p></p> <ul> <li><a href="/medschool/">School of Medicine</a></li> <li><a href="/nursing/">Betty Irene Moore School of Nursing</a></li> <li><a href="/leadership/pmg.html">Medical Group</a></li> <li><a href="/medicalcenter/">Medical Center</a></li> </ul> <p></p> </div> <div class="col-33percent-sm"> <h5> Connect with Us </h5> <p>Stay connected with what’s happening at UC Davis Health.</p>  <div class="socialmedia icon-sm"><a href="https://www.facebook.com/UCDavisHealth" rel="noopener" title="Like us on Facebook" target="_blank"><img src="/global/images/icons/Facebook-48x48.svg" alt="Facebook icon" /></a> <a href="http://twitter.com/UCDavisHealth" rel="noopener" title="Follow us on Twitter" target="_blank"><img src="/global/images/icons/Twitter-48x48.svg" alt="Twitter icon" /></a> <a href="http://www.youtube.com/ucdavishealth" rel="noopener" title="Subscribe to our channel on YouTube" target="_blank"><img src="/global/images/icons/YouTube-48x48.svg" alt="YouTube icon" /></a> <a href="http://pinterest.com/ucdavishealth/" rel="noopener" target="_blank"><img src="/global/images/icons/Pinterest-48x48.svg" alt="Pinterest icon" title="Follow us on Pinterest" /></a> <a href="/newsroom/socialmedia/index.html#RSS" title=""News"><img src="/global/images/icons/RSS-48x48.svg" alt="RSS feed icon" /></a> <a href="http://www.instagram.com/ucdavishealth" rel="noopener" title="Follow us on Instagram" target="_blank"><img src="/global/images/icons/Instagram-48x48.svg" alt="Instagram icon" /></a> <a href="https://www.linkedin.com/company/uc-davis-health-system" rel="noopener" title="Follow us on LinkedIn" target="_blank"><img src="/global/images/icons/LinkedIn-48x48.svg" alt="LinkedIn icon" /></a></div> <p> </p>  <p class="pull-right"><a href="#">Back to top</a></p> </div> </div>  <div class="footer-inner"> <h5><a href="/ctrr/">Center for Tissue Regeneration and Repair</a><a href="https://give.ucdavis.edu/Area"><img src="/global/images/buttons/giving/make-a-gift.svg" alt="Give to UC Davis Health" width="129" height="32" class="make-a-gift" title="Give to UC Davis Health"></a></h5> <p>4635 2nd Ave Research 1 |  Sacramento, CA 95817  |  Main Line: <a href="tel:916-734-5749">916-734-5749</a>  |  FAX: <a href="tel:916-734-5750">916-734-5750</a> <br> <a href="https://health.ucdavis.edu/legal">© <span id="copyright_year">2014</span> UC Regents.</a> All Rights Reserved  |  <a href="/legal/" target="_self">Legal</a>  |  <a href="https://hr.ucdavis.edu/" target="_self">Careers</a>  |  <a href="/ctrr/contactus/index.html" target="_self">Contact Us</a> </p> </div> </footer> </div> <script language="javascript"> document.getElementById('copyright_year').innerHTML = copyright(); </script>   <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MCCPMDR');</script>     <script src="/global/design/responsive/utility/jquery.fitvids.js"></script> <script> $(document).ready(function(){ $(".video-wrapper").fitVids(); }); </script>  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MCCPMDR" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  </body> </html>

CINXE.COM

Center for Tissue Regeneration and Repair