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Myxoid liposarcoma - Wikipedia
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id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Myxoid liposarcoma</th></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Histopathology_of_myxoid_liposarcoma.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/Histopathology_of_myxoid_liposarcoma.png/220px-Histopathology_of_myxoid_liposarcoma.png" decoding="async" width="220" height="188" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/Histopathology_of_myxoid_liposarcoma.png/330px-Histopathology_of_myxoid_liposarcoma.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/96/Histopathology_of_myxoid_liposarcoma.png/440px-Histopathology_of_myxoid_liposarcoma.png 2x" data-file-width="528" data-file-height="451" /></a></span></td></tr><tr><td colspan="2" class="infobox-full-data">Histopathologic image of myxoid liposarcoma arising in the thigh. H & E stain.</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Oncology" title="Oncology">Oncology</a> <span class="penicon autoconfirmed-show"><span class="mw-valign-text-top" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q6949365?uselang=en#P1995" title="Edit this on Wikidata"><img alt="Edit this on Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></td></tr></tbody></table> <p>A <b>myxoid liposarcoma</b> is a <a href="/wiki/Cancer" title="Cancer">malignant</a> <a href="/wiki/Adipose_tissue_neoplasm" title="Adipose tissue neoplasm">adipose tissue neoplasm</a><sup id="cite_ref-Singer2013_1-0" class="reference"><a href="#cite_note-Singer2013-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> of <a href="/wiki/Myxoid_tumor" title="Myxoid tumor">myxoid</a> appearance histologically. </p><p>Myxoid liposarcomas are the second-most common type of <a href="/wiki/Liposarcoma" title="Liposarcoma">liposarcoma</a>, representing 30–40% of all liposarcomas in the limbs, occurring most commonly in the legs, particularly the thigh, followed by the buttocks, retroperitoneum, trunk, ankle, proximal limb girdle, head and neck, and wrist. They occur in the intermuscular <a href="/wiki/Fascial_plane" class="mw-redirect" title="Fascial plane">fascial planes</a> or deep-seated areas. They present as a large, slow-growing, painless mass.<sup id="cite_ref-Sung2000_2-0" class="reference"><a href="#cite_note-Sung2000-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>The neoplastic cells in these neoplasms contain <a href="/wiki/Chromosomal_translocation" title="Chromosomal translocation">chromosomal translocations</a> which create one of two <a href="/wiki/Fusion_gene" title="Fusion gene">fusion genes</a>: the <i><a href="/wiki/RNA-binding_protein_FUS" title="RNA-binding protein FUS">FUS</a>-<a href="/wiki/DDIT3" class="mw-redirect" title="DDIT3">DDIT3</a></i> in ~90% and the <i><a href="/wiki/EWSR1" class="mw-redirect" title="EWSR1">EWSR1</a>-DDIT3</i> fusion gene in up to 10% of myxoid liposarcoma cases.<sup id="cite_ref-pmid34203801_3-0" class="reference"><a href="#cite_note-pmid34203801-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The <i>FUS-DDIT3</i> fusion gene forms by a merger of part of the <a href="/wiki/FUS_(gene)" class="mw-redirect" title="FUS (gene)">FUS</a> <a href="/wiki/FET_protein_family" title="FET protein family">FET gene family</a> gene normally located at <a href="/wiki/Karyotype#Types_of_banding" title="Karyotype">band</a> 11.2 on the <a href="/wiki/Locus_(genetics)#Nomenclature" title="Locus (genetics)">short (or "p") arm</a> of <a href="/wiki/Chromosome_16" title="Chromosome 16">chromosome 16</a> with part of the <i>DDIT3</i> <a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS transcription factor family</a> gene normally located at band 13.3 on the long (or "q") arm of <a href="/wiki/Chromosome_12" title="Chromosome 12">chromosome 12</a>. This fusion gene is notated as t(12;16)(q13;p11).<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid18850010_5-0" class="reference"><a href="#cite_note-pmid18850010-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Preclinical_studies" class="mw-redirect" title="Preclinical studies">Preclinical studies</a>, i.e. laboratory studies, suggest that the <i>FUS-DDIT3</i> fusion gene may act as an <a href="/wiki/Oncogene" title="Oncogene">oncogene</a> to promote the development of myxoid liposarmas.<sup id="cite_ref-pmid34357401_6-0" class="reference"><a href="#cite_note-pmid34357401-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The <i>EWSR1-DDIT3</i> fusion gene forms by a merger of the <i><a href="/wiki/EWSR1" class="mw-redirect" title="EWSR1">EWSR1</a></i> FET gene family gene located at band 12.2 on the q arm of <a href="/wiki/Chromosome_22" title="Chromosome 22">chromosome 22</a> with part of the <i>DDIT3</i> gene. This fusion gene is notated as t(12;22)(q13;12).<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19190116_9-0" class="reference"><a href="#cite_note-pmid19190116-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Additional_images">Additional images</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myxoid_liposarcoma&action=edit&section=1" title="Edit section: Additional images"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul class="gallery mw-gallery-packed"> <li class="gallerybox" style="width: 268px"> <div class="thumb" style="width: 266px;"><span typeof="mw:File"><a href="/wiki/File:Myxoid_liposarcoma_(06).JPG" class="mw-file-description" title="Micrograph of myxoid liposarcoma. H&E stain"><img alt="Micrograph of myxoid liposarcoma. H&E stain" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/Myxoid_liposarcoma_%2806%29.JPG/399px-Myxoid_liposarcoma_%2806%29.JPG" decoding="async" width="266" height="200" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/Myxoid_liposarcoma_%2806%29.JPG/598px-Myxoid_liposarcoma_%2806%29.JPG 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/78/Myxoid_liposarcoma_%2806%29.JPG/797px-Myxoid_liposarcoma_%2806%29.JPG 2x" data-file-width="2040" data-file-height="1536" /></a></span></div> <div class="gallerytext"><a href="/wiki/Micrograph" title="Micrograph">Micrograph</a> of myxoid liposarcoma. <a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a></div> </li> <li class="gallerybox" style="width: 194px"> <div class="thumb" style="width: 192px;"><span typeof="mw:File"><a href="/wiki/File:HG_mixoid_liposarcoma,_MRI,_2019,_10,_13.png" class="mw-file-description" title="MRI of myxoid liposarcoma of high grade, in left axillary region of 40 year old man. Horizontal section."><img alt="MRI of myxoid liposarcoma of high grade, in left axillary region of 40 year old man. Horizontal section." src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/HG_mixoid_liposarcoma%2C_MRI%2C_2019%2C_10%2C_13.png/288px-HG_mixoid_liposarcoma%2C_MRI%2C_2019%2C_10%2C_13.png" decoding="async" width="192" height="200" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/HG_mixoid_liposarcoma%2C_MRI%2C_2019%2C_10%2C_13.png/431px-HG_mixoid_liposarcoma%2C_MRI%2C_2019%2C_10%2C_13.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/HG_mixoid_liposarcoma%2C_MRI%2C_2019%2C_10%2C_13.png/575px-HG_mixoid_liposarcoma%2C_MRI%2C_2019%2C_10%2C_13.png 2x" data-file-width="876" data-file-height="914" /></a></span></div> <div class="gallerytext"><a href="/wiki/MRI" class="mw-redirect" title="MRI">MRI</a> of myxoid liposarcoma of high grade, in left axillary region of 40 year old man. Horizontal section.</div> </li> </ul> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myxoid_liposarcoma&action=edit&section=2" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Lipoma" title="Lipoma">Lipoma</a></li> <li><a href="/wiki/Trabectedin" title="Trabectedin">Trabectedin</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myxoid_liposarcoma&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-Singer2013-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Singer2013_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=99967">"Orphanet: Myxoid/round cell liposarcoma"</a>. <i>Orpha.net</i><span class="reference-accessdate">. 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"Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". <i>Nature</i>. <b>363</b> (6430): 640–4. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1993Natur.363..640C">1993Natur.363..640C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F363640a0">10.1038/363640a0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8510758">8510758</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4358184">4358184</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Fusion+of+CHOP+to+a+novel+RNA-binding+protein+in+human+myxoid+liposarcoma&rft.volume=363&rft.issue=6430&rft.pages=640-4&rft.date=1993&rft_id=info%3Adoi%2F10.1038%2F363640a0&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4358184%23id-name%3DS2CID&rft_id=info%3Apmid%2F8510758&rft_id=info%3Abibcode%2F1993Natur.363..640C&rft.aulast=Crozat&rft.aufirst=A&rft.au=Aman%2C+P&rft.au=Mandahl%2C+N&rft.au=Ron%2C+D&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMyxoid+liposarcoma" class="Z3988"></span></span> </li> <li id="cite_note-pmid19190116-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19190116_9-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFForniMinuzzoVirdis2009" class="citation journal cs1">Forni C, Minuzzo M, Virdis E, et al. (February 2009). <a rel="nofollow" class="external text" href="http://mct.aacrjournals.org/cgi/pmidlookup?view=long&pmid=19190116">"Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors"</a>. <i>Mol. Cancer Ther</i>. <b>8</b> (2): 449–57. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1158%2F1535-7163.MCT-08-0848">10.1158/1535-7163.MCT-08-0848</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19190116">19190116</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mol.+Cancer+Ther.&rft.atitle=Trabectedin+%28ET-743%29+promotes+differentiation+in+myxoid+liposarcoma+tumors&rft.volume=8&rft.issue=2&rft.pages=449-57&rft.date=2009-02&rft_id=info%3Adoi%2F10.1158%2F1535-7163.MCT-08-0848&rft_id=info%3Apmid%2F19190116&rft.aulast=Forni&rft.aufirst=C&rft.au=Minuzzo%2C+M&rft.au=Virdis%2C+E&rft_id=http%3A%2F%2Fmct.aacrjournals.org%2Fcgi%2Fpmidlookup%3Fview%3Dlong%26pmid%3D19190116&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMyxoid+liposarcoma" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Myxoid_liposarcoma&action=edit&section=4" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678127/">Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance</a></li> <li><a rel="nofollow" class="external text" href="http://www.clinicalsarcomaresearch.com/content/pdf/2045-3329-2-2.pdf">Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma. 2012</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 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dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style></div><div role="navigation" class="navbox" aria-label="Navbox" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q6949365" class="extiw" title="d:Q6949365">D</a></div><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/International_Classification_of_Diseases_for_Oncology" title="International Classification of Diseases for Oncology">ICD-O</a></b>: 8852/3</li><li><b><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></b>: <a rel="nofollow" class="external text" href="https://omim.org/entry/613488">613488</a></li><li><b><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></b>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D018208">D018208</a></li></ul></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Connective/soft_tissue_tumors_and_sarcomas" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Soft_tissue_tumors_and_sarcomas" title="Template:Soft tissue tumors and sarcomas"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Soft_tissue_tumors_and_sarcomas" title="Template talk:Soft tissue tumors and sarcomas"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Soft_tissue_tumors_and_sarcomas" title="Special:EditPage/Template:Soft tissue tumors and sarcomas"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Connective/soft_tissue_tumors_and_sarcomas" style="font-size:114%;margin:0 4em"><a href="/wiki/Connective_tissue" title="Connective tissue">Connective</a>/<a href="/wiki/Soft_tissue" title="Soft tissue">soft tissue</a> <a href="/wiki/Neoplasm" title="Neoplasm">tumors</a> and <a href="/wiki/Sarcoma" title="Sarcoma">sarcomas</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Not otherwise specified</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Soft-tissue_sarcoma" title="Soft-tissue sarcoma">Soft-tissue sarcoma</a></li> <li><a href="/wiki/Desmoplastic_small-round-cell_tumor" title="Desmoplastic small-round-cell tumor">Desmoplastic small-round-cell tumor</a></li> <li><a href="/wiki/Skin_sarcoma" title="Skin sarcoma">Skin sarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Connective_tissue_neoplasm" title="Connective tissue neoplasm">Connective tissue neoplasm</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibrous_tissue_neoplasm" title="Fibrous tissue neoplasm">Fibromatous</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroma" title="Fibroma">Fibroma</a>/<a href="/wiki/Fibrosarcoma" title="Fibrosarcoma">fibrosarcoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dermatofibrosarcoma_protuberans" title="Dermatofibrosarcoma protuberans">Dermatofibrosarcoma protuberans</a></li> <li><a href="/wiki/Desmoplastic_fibroma" title="Desmoplastic fibroma">Desmoplastic fibroma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroma" title="Fibroma">Fibroma</a>/<a href="/wiki/Fibromatosis" title="Fibromatosis">fibromatosis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aggressive_fibromatosis" title="Aggressive fibromatosis">Aggressive fibromatosis</a></li> <li><a href="/wiki/Aggressive_infantile_fibromatosis" class="mw-redirect" title="Aggressive infantile fibromatosis">Aggressive infantile fibromatosis</a></li> <li><a href="/wiki/Aponeurotic_fibroma" title="Aponeurotic fibroma">Aponeurotic fibroma</a></li> <li><a href="/wiki/Collagenous_fibroma" title="Collagenous fibroma">Collagenous fibroma</a></li> <li><a href="/wiki/Diffuse_infantile_fibromatosis" title="Diffuse infantile fibromatosis">Diffuse infantile fibromatosis</a></li> <li>Familial myxovascular fibromas</li> <li><a href="/wiki/Fibroma_of_tendon_sheath" title="Fibroma of tendon sheath">Fibroma of tendon sheath</a></li> <li><a href="/wiki/Fibromatosis_colli" title="Fibromatosis colli">Fibromatosis colli</a></li> <li><a href="/wiki/Infantile_digital_fibromatosis" title="Infantile digital fibromatosis">Infantile digital fibromatosis</a></li> <li><a href="/wiki/Juvenile_hyaline_fibromatosis" title="Juvenile hyaline fibromatosis">Juvenile hyaline fibromatosis</a></li> <li><a href="/wiki/Plantar_fibromatosis" title="Plantar fibromatosis">Plantar fibromatosis</a></li> <li><a href="/wiki/Pleomorphic_fibroma" title="Pleomorphic fibroma">Pleomorphic fibroma</a></li> <li><a href="/wiki/Oral_submucous_fibrosis" title="Oral submucous fibrosis">Oral submucous fibrosis</a></li> <li><a href="/wiki/Pachydermodactyly" title="Pachydermodactyly">Pachydermodactyly</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Histiocytoma" title="Histiocytoma">Histiocytoma</a>/<a href="/wiki/Histiocytic_sarcoma" title="Histiocytic sarcoma">histiocytic sarcoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benign_fibrous_histiocytoma" class="mw-redirect" title="Benign fibrous histiocytoma">Benign fibrous histiocytoma</a></li> <li><a href="/wiki/Pleomorphic_undifferentiated_sarcoma" class="mw-redirect" title="Pleomorphic undifferentiated sarcoma">Malignant fibrous histiocytoma</a></li> <li><a href="/wiki/Atypical_fibroxanthoma" title="Atypical fibroxanthoma">Atypical fibroxanthoma</a></li> <li><a href="/wiki/Solitary_fibrous_tumor" title="Solitary fibrous tumor">Solitary fibrous tumor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myxoma" title="Myxoma">Myxomatous</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myxoma" title="Myxoma">Myxoma</a>/<a href="/wiki/Myxosarcoma" title="Myxosarcoma">myxosarcoma</a> <ul><li><a href="/wiki/Cutaneous_myxoma" title="Cutaneous myxoma">Cutaneous myxoma</a></li> <li><a href="/wiki/Superficial_acral_fibromyxoma" title="Superficial acral fibromyxoma">Superficial acral fibromyxoma</a></li></ul></li> <li><a href="/wiki/Aggressive_angiomyxoma" title="Aggressive angiomyxoma">Angiomyxoma</a></li> <li><a href="/wiki/Ossifying_fibromyxoid_tumour" title="Ossifying fibromyxoid tumour">Ossifying fibromyxoid tumour</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroepithelial_neoplasms" class="mw-redirect" title="Fibroepithelial neoplasms">Fibroepithelial</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Brenner_tumour" title="Brenner tumour">Brenner tumour</a></li> <li><a href="/wiki/Fibroadenoma" title="Fibroadenoma">Fibroadenoma</a></li> <li><a href="/wiki/Phyllodes_tumor" title="Phyllodes tumor">Phyllodes tumor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Synovial_joint" title="Synovial joint">Synovial</a>-like</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Synovial_sarcoma" title="Synovial sarcoma">Synovial sarcoma</a></li> <li><a href="/wiki/Clear-cell_sarcoma" class="mw-redirect" title="Clear-cell sarcoma">Clear-cell sarcoma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adipose_tissue_neoplasm" title="Adipose tissue neoplasm">Lipomatous</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lipoma" title="Lipoma">Lipoma</a>/<a href="/wiki/Liposarcoma" title="Liposarcoma">liposarcoma</a> <ul><li><a href="/wiki/Myelolipoma" title="Myelolipoma">Myelolipoma</a></li> <li><a class="mw-selflink selflink">Myxoid liposarcoma</a></li></ul></li> <li><a href="/wiki/Perivascular_epithelioid_cell_tumour" title="Perivascular epithelioid cell tumour">PEComa</a> <ul><li><a href="/wiki/Angiomyolipoma" title="Angiomyolipoma">Angiomyolipoma</a></li></ul></li></ul> <ul><li><a href="/wiki/Chondroid_lipoma" title="Chondroid lipoma">Chondroid lipoma</a></li> <li><a href="/wiki/Intradermal_spindle_cell_lipoma" class="mw-redirect" title="Intradermal spindle cell lipoma">Intradermal spindle cell lipoma</a></li> <li><a href="/wiki/Pleomorphic_lipoma" title="Pleomorphic lipoma">Pleomorphic lipoma</a></li> <li><a href="/wiki/Lipoblastomatosis" title="Lipoblastomatosis">Lipoblastomatosis</a></li> <li><a href="/wiki/Spindle_cell_lipoma" title="Spindle cell lipoma">Spindle cell lipoma</a></li> <li><a href="/wiki/Hibernoma" title="Hibernoma">Hibernoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Muscle_tissue_neoplasm" class="mw-redirect" title="Muscle tissue neoplasm">Myomatous</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">General</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myoma" title="Myoma">Myoma</a>/<a href="/wiki/Myosarcoma" title="Myosarcoma">myosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><a href="/wiki/Smooth_muscle_tissue" class="mw-redirect" title="Smooth muscle tissue">Smooth muscle</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leiomyoma" title="Leiomyoma">Leiomyoma</a>/<a href="/wiki/Leiomyosarcoma" title="Leiomyosarcoma">leiomyosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><a href="/wiki/Skeletal_muscle" title="Skeletal muscle">Skeletal muscle</a></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rhabdomyoma" title="Rhabdomyoma">Rhabdomyoma</a>/<a href="/wiki/Rhabdomyosarcoma" title="Rhabdomyosarcoma">rhabdomyosarcoma</a>: <a href="/wiki/Embryonal_rhabdomyosarcoma" title="Embryonal rhabdomyosarcoma">Embryonal rhabdomyosarcoma</a> <ul><li><a href="/wiki/Sarcoma_botryoides" title="Sarcoma botryoides">Sarcoma botryoides</a></li></ul></li> <li><a href="/wiki/Alveolar_rhabdomyosarcoma" title="Alveolar rhabdomyosarcoma">Alveolar rhabdomyosarcoma</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leiomyoma" title="Leiomyoma">Leiomyoma</a> <ul><li><a href="/wiki/Cutaneous_leiomyoma" title="Cutaneous leiomyoma">Cutaneous</a></li></ul></li> <li><a href="/wiki/Angioleiomyoma" title="Angioleiomyoma">Angioleiomyoma</a></li> <li><a href="/wiki/Angiolipoleiomyoma" title="Angiolipoleiomyoma">Angiolipoleiomyoma</a></li> <li><a href="/wiki/Genital_leiomyoma" title="Genital leiomyoma">Genital leiomyoma</a></li> <li><a href="/wiki/Leiomyosarcoma" title="Leiomyosarcoma">Leiomyosarcoma</a></li> <li><a href="/wiki/Hereditary_leiomyomatosis_and_renal_cell_cancer_syndrome" title="Hereditary leiomyomatosis and renal cell cancer syndrome">Multiple cutaneous and uterine leiomyomatosis syndrome</a></li> <li><a href="/wiki/Multiple_cutaneous_leiomyoma" class="mw-redirect" title="Multiple cutaneous leiomyoma">Multiple cutaneous leiomyoma</a></li> <li><a href="/wiki/Neural_fibrolipoma" title="Neural fibrolipoma">Neural fibrolipoma</a></li> <li><a href="/wiki/Solitary_cutaneous_leiomyoma" class="mw-redirect" title="Solitary cutaneous leiomyoma">Solitary cutaneous leiomyoma</a></li> <li><a href="/wiki/Smooth_muscle_tumor_of_uncertain_malignant_potential" title="Smooth muscle tumor of uncertain malignant potential">STUMP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Complex_and_mixed_tumor" class="mw-redirect" title="Complex and mixed tumor">Complex mixed and stromal</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenomyoma" title="Adenomyoma">Adenomyoma</a></li> <li><a href="/wiki/Pleomorphic_adenoma" title="Pleomorphic adenoma">Pleomorphic adenoma</a></li> <li><a href="/wiki/Mixed_M%C3%BCllerian_tumor" title="Mixed Müllerian tumor">Mixed Müllerian tumor</a></li> <li><a href="/wiki/Mesoblastic_nephroma" title="Mesoblastic nephroma">Mesoblastic nephroma</a></li> <li><a href="/wiki/Wilms%27_tumor" title="Wilms' tumor">Wilms' tumor</a></li> <li><a href="/wiki/Malignant_rhabdoid_tumour" title="Malignant rhabdoid tumour">Malignant rhabdoid tumour</a></li> <li><a href="/wiki/Clear-cell_sarcoma_of_the_kidney" title="Clear-cell sarcoma of the kidney">Clear-cell sarcoma of the kidney</a></li> <li><a href="/wiki/Hepatoblastoma" title="Hepatoblastoma">Hepatoblastoma</a></li> <li><a href="/wiki/Pancreatoblastoma" title="Pancreatoblastoma">Pancreatoblastoma</a></li> <li><a href="/wiki/Carcinosarcoma" title="Carcinosarcoma">Carcinosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mesothelium" title="Mesothelium">Mesothelial</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mesothelioma" title="Mesothelioma">Mesothelioma</a></li> <li><a href="/wiki/Adenomatoid_tumor" title="Adenomatoid tumor">Adenomatoid tumor</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Chromosome_abnormalities" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Chromosomal_abnormalities" title="Template:Chromosomal abnormalities"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Chromosomal_abnormalities" title="Template talk:Chromosomal abnormalities"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Chromosomal_abnormalities" title="Special:EditPage/Template:Chromosomal abnormalities"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Chromosome_abnormalities" style="font-size:114%;margin:0 4em"><a href="/wiki/Chromosome_abnormality" title="Chromosome abnormality">Chromosome abnormalities</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Autosome" title="Autosome">Autosomal</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Duplications,<br />including <a href="/wiki/Trisomy" title="Trisomy">trisomies</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/1q21.1_duplication_syndrome" title="1q21.1 duplication syndrome">1q21.1 duplication syndrome</a></li> <li><a href="/wiki/Syndactyly-nystagmus_syndrome_due_to_2q31.1_microduplication" title="Syndactyly-nystagmus syndrome due to 2q31.1 microduplication">2q31.1 microduplication</a></li> <li><a href="/wiki/Trisomy_8" title="Trisomy 8">Trisomy 8</a></li> <li><a href="/wiki/Trisomy_9" title="Trisomy 9">Trisomy 9</a></li> <li><a href="/wiki/Tetrasomy_9p" title="Tetrasomy 9p">Tetrasomy 9p</a></li> <li><a href="/wiki/Distal_trisomy_10q" title="Distal trisomy 10q">Distal trisomy 10q</a></li> <li><a href="/wiki/Patau_syndrome" title="Patau syndrome">Patau syndrome</a> <ul><li><a href="/wiki/Chromosome_13" title="Chromosome 13">13</a></li></ul></li> <li><a href="/wiki/Trisomy_16" title="Trisomy 16">Trisomy 16</a></li> <li><a href="/wiki/16p11.2_duplication_syndrome" title="16p11.2 duplication syndrome">16p11.2 duplication syndrome</a></li> <li><a href="/wiki/Trisomy_18" title="Trisomy 18">Trisomy 18</a></li> <li><a href="/wiki/Down_syndrome" title="Down syndrome">Down syndrome</a> <ul><li><a href="/wiki/Chromosome_21" title="Chromosome 21">21</a></li></ul></li> <li><a href="/wiki/22q11.2_duplication_syndrome" title="22q11.2 duplication syndrome">22q11.2 duplication syndrome</a></li> <li><a href="/wiki/Trisomy_22" title="Trisomy 22">Trisomy 22</a></li> <li><a href="/wiki/Cat_eye_syndrome" title="Cat eye syndrome">Cat-eye syndrome</a> <ul><li><a href="/wiki/Chromosome_22" title="Chromosome 22">22</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Deletion_(genetics)" title="Deletion (genetics)">Deletions</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>(<a href="/wiki/1q21.1_copy_number_variations" title="1q21.1 copy number variations">1q21.1 copy number variations</a>/<a href="/wiki/1q21.1_deletion_syndrome" title="1q21.1 deletion syndrome">1q21.1 deletion syndrome</a>/<a href="/wiki/1q21.1_duplication_syndrome" title="1q21.1 duplication syndrome">1q21.1 duplication syndrome</a>/<a href="/wiki/TAR_syndrome" title="TAR syndrome">TAR syndrome</a>/<a href="/wiki/1p36_deletion_syndrome" title="1p36 deletion syndrome">1p36 deletion syndrome</a>) <ul><li><a href="/wiki/Chromosome_1" title="Chromosome 1">1</a></li></ul></li> <li><a href="/wiki/Wolf%E2%80%93Hirschhorn_syndrome" title="Wolf–Hirschhorn syndrome">Wolf–Hirschhorn syndrome</a> <ul><li><a href="/wiki/Chromosome_4" title="Chromosome 4">4</a></li></ul></li> <li><a href="/wiki/Cri_du_chat_syndrome" title="Cri du chat syndrome">Cri du chat syndrome</a>/<a href="/wiki/Chromosome_5q_deletion_syndrome" title="Chromosome 5q deletion syndrome">Chromosome 5q deletion syndrome</a> <ul><li><a href="/wiki/Chromosome_5" title="Chromosome 5">5</a></li></ul></li> <li><a href="/wiki/Williams_syndrome" title="Williams syndrome">Williams syndrome</a> <ul><li><a href="/wiki/Chromosome_7" title="Chromosome 7">7</a></li></ul></li> <li><a href="/wiki/Jacobsen_syndrome" title="Jacobsen syndrome">Jacobsen syndrome</a> <ul><li><a href="/wiki/Chromosome_11" title="Chromosome 11">11</a></li></ul></li> <li><a href="/wiki/Miller%E2%80%93Dieker_syndrome" title="Miller–Dieker syndrome">Miller–Dieker syndrome</a>/<a href="/wiki/Smith%E2%80%93Magenis_syndrome" title="Smith–Magenis syndrome">Smith–Magenis syndrome</a>/<a href="/wiki/17q12_microdeletion_syndrome" title="17q12 microdeletion syndrome">17q12 microdeletion syndrome</a> <ul><li><a href="/wiki/Chromosome_17" title="Chromosome 17">17</a></li></ul></li> <li><a href="/wiki/DiGeorge_syndrome" title="DiGeorge syndrome">DiGeorge syndrome</a> <ul><li><a href="/wiki/Chromosome_22" title="Chromosome 22">22</a></li></ul></li> <li><a href="/wiki/22q11.2_distal_deletion_syndrome" title="22q11.2 distal deletion syndrome">22q11.2 distal deletion syndrome</a> <ul><li><a href="/wiki/Chromosome_22" title="Chromosome 22">22</a></li></ul></li> <li><a href="/wiki/22q13_deletion_syndrome" title="22q13 deletion syndrome">22q13 deletion syndrome</a> <ul><li><a href="/wiki/Chromosome_22" title="Chromosome 22">22</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Genomic_imprinting" title="Genomic imprinting">genomic imprinting</a></i> <ul><li><a href="/wiki/Angelman_syndrome" title="Angelman syndrome">Angelman syndrome</a>/<a href="/wiki/Prader%E2%80%93Willi_syndrome" title="Prader–Willi syndrome">Prader–Willi syndrome</a> (<a href="/wiki/Chromosome_15" title="Chromosome 15">15</a>)</li></ul></li></ul> <ul><li><a href="/wiki/Distal_18q-" title="Distal 18q-">Distal 18q-</a>/<a href="/wiki/Proximal_18q-" title="Proximal 18q-">Proximal 18q-</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/X_chromosome" title="X chromosome">X</a>/<a href="/wiki/Y_chromosome" title="Y chromosome">Y</a> linked</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Monosomy" title="Monosomy">Monosomies</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Turner_syndrome" title="Turner syndrome">Turner syndrome (45,X)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Trisomy" title="Trisomy">Trisomies</a>/<a href="/wiki/Tetrasomy" title="Tetrasomy">tetrasomies</a>,<br /><a href="/wiki/Aneuploidy" title="Aneuploidy">other karyotypes</a>/<a href="/wiki/Mosaic_(genetics)" title="Mosaic (genetics)">mosaics</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Klinefelter_syndrome" title="Klinefelter syndrome">Klinefelter syndrome (47,XXY)</a></li> <li><a href="/wiki/XXYY_syndrome" title="XXYY syndrome">XXYY syndrome (48,XXYY)</a></li> <li><a href="/wiki/XXXY_syndrome" title="XXXY syndrome">XXXY syndrome (48,XXXY)</a></li> <li><a href="/wiki/XXXYY_syndrome" title="XXXYY syndrome">XXXYY syndrome (49,XXXYY)</a></li> <li><a href="/wiki/XXXXY_syndrome" title="XXXXY syndrome">XXXXY syndrome (49,XXXXY)</a></li></ul> <ul><li><a href="/wiki/Trisomy_X" title="Trisomy X">Trisomy X (47,XXX)</a></li> <li><a href="/wiki/Tetrasomy_X" title="Tetrasomy X">Tetrasomy X (48,XXXX)</a></li> <li><a href="/wiki/Pentasomy_X" title="Pentasomy X">Pentasomy X (49,XXXXX)</a></li></ul> <ul><li><a href="/wiki/XYY_syndrome" title="XYY syndrome">XYY syndrome (47,XYY)</a></li> <li><a href="/wiki/XYYY_syndrome" title="XYYY syndrome">XYYY syndrome (48,XYYY)</a></li> <li><a href="/wiki/XYYYY_syndrome" title="XYYYY syndrome">XYYYY syndrome (49,XYYYY)</a></li></ul> <ul><li><a href="/wiki/45,X/46,XY_mosaicism" title="45,X/46,XY mosaicism">45,X/46,XY</a></li> <li><a href="/wiki/46,XX/46,XY" title="46,XX/46,XY">46,XX/46,XY</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chromosomal_translocation" title="Chromosomal translocation">Translocations</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leukemia" title="Leukemia">Leukemia</a>/<a href="/wiki/Lymphoma" title="Lymphoma">lymphoma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Lymphoid</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Burkitt_lymphoma" title="Burkitt lymphoma">Burkitt lymphoma</a> t(8 <a href="/wiki/Myc" title="Myc">MYC</a>;14 <a href="/wiki/IGH@" title="IGH@">IGH</a>)</li> <li><a href="/wiki/Follicular_lymphoma" title="Follicular lymphoma">Follicular lymphoma</a> t(14 <a href="/wiki/IGH@" title="IGH@">IGH</a>;18 <a href="/wiki/Bcl-2" title="Bcl-2">BCL2</a>)</li> <li><a href="/wiki/Mantle_cell_lymphoma" title="Mantle cell lymphoma">Mantle cell lymphoma</a>/<a href="/wiki/Multiple_myeloma" title="Multiple myeloma">Multiple myeloma</a> <a href="/wiki/T(11:14)" title="T(11:14)">t(11 CCND1:14 IGH)</a></li> <li><a href="/wiki/Anaplastic_large-cell_lymphoma" title="Anaplastic large-cell lymphoma">Anaplastic large-cell lymphoma </a> t(2 <a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">ALK</a>;5 <a href="/wiki/NPM1" title="NPM1">NPM1</a>)</li> <li><a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">Acute lymphoblastic leukemia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Myeloid</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Philadelphia_chromosome" title="Philadelphia chromosome">Philadelphia chromosome</a> t(9 <a href="/wiki/ABL_(gene)" title="ABL (gene)">ABL</a>; 22 <a href="/wiki/BCR_(gene)" title="BCR (gene)">BCR</a>)</li> <li><a href="/wiki/Acute_myeloblastic_leukemia_with_maturation" title="Acute myeloblastic leukemia with maturation">Acute myeloblastic leukemia with maturation</a> t(8 <a href="/wiki/RUNX1T1" title="RUNX1T1">RUNX1T1</a>;21 <a href="/wiki/RUNX1" title="RUNX1">RUNX1</a>)</li> <li><a href="/wiki/Acute_promyelocytic_leukemia" title="Acute promyelocytic leukemia">Acute promyelocytic leukemia</a> t(15 <a href="/wiki/Promyelocytic_leukemia_protein" title="Promyelocytic leukemia protein">PML</a>,17 <a href="/wiki/Retinoic_acid_receptor_alpha" title="Retinoic acid receptor alpha">RARA</a>)</li> <li><a href="/wiki/Acute_megakaryoblastic_leukemia" title="Acute megakaryoblastic leukemia">Acute megakaryoblastic leukemia</a> t(1 <a href="/wiki/RBM15" title="RBM15">RBM15</a>;22 <a href="/wiki/MKL1" title="MKL1">MKL1</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ewing_sarcoma" title="Ewing sarcoma">Ewing sarcoma</a> t(11 <a href="/wiki/FLI1" title="FLI1">FLI1</a>; 22 <a href="/wiki/RNA-binding_protein_EWS" title="RNA-binding protein EWS">EWS</a>)</li> <li><a href="/wiki/Synovial_sarcoma" title="Synovial sarcoma">Synovial sarcoma</a> t(x <a href="/wiki/SYT1" title="SYT1">SYT</a>;18 <a href="/wiki/Synovial_sarcoma,_X_breakpoint" title="Synovial sarcoma, X breakpoint">SSX</a>)</li> <li><a href="/wiki/Dermatofibrosarcoma_protuberans" title="Dermatofibrosarcoma protuberans">Dermatofibrosarcoma protuberans</a> t(17 <a href="/wiki/Collagen,_type_I,_alpha_1" title="Collagen, type I, alpha 1">COL1A1</a>;22 <a href="/wiki/PDGFB" title="PDGFB">PDGFB</a>)</li> <li><a class="mw-selflink selflink">Myxoid liposarcoma</a> t(12 <a href="/wiki/DNA_damage-inducible_transcript_3" title="DNA damage-inducible transcript 3">DDIT3</a>; 16 <a href="/wiki/RNA-binding_protein_FUS" title="RNA-binding protein FUS">FUS</a>)</li> <li><a href="/wiki/Desmoplastic_small-round-cell_tumor" title="Desmoplastic small-round-cell tumor">Desmoplastic small-round-cell tumor</a> t(11 <a href="/wiki/Wilms_tumor_protein" title="Wilms tumor protein">WT1</a>; 22 <a href="/wiki/RNA-binding_protein_EWS" title="RNA-binding protein EWS">EWS</a>)</li> <li><a href="/wiki/Alveolar_rhabdomyosarcoma" title="Alveolar rhabdomyosarcoma">Alveolar rhabdomyosarcoma</a> t(2 <a href="/wiki/PAX3" title="PAX3">PAX3</a>; 13 <a href="/wiki/Forkhead_box_protein_O1" title="Forkhead box protein O1">FOXO1</a>) t (1 <a href="/wiki/PAX7" title="PAX7">PAX7</a>; 13 <a href="/wiki/Forkhead_box_protein_O1" title="Forkhead box protein O1">FOXO1</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fragile_X_syndrome" title="Fragile X syndrome">Fragile X syndrome</a></li> <li><a href="/wiki/Uniparental_disomy" title="Uniparental disomy">Uniparental disomy</a></li> <li><a href="/wiki/XX_male_syndrome" title="XX male syndrome">XX male syndrome</a>/<a href="/wiki/XX_male_syndrome" title="XX male syndrome">46,XX testicular disorders of sex development</a></li> <li><a href="/wiki/Marker_chromosome" title="Marker chromosome">Marker chromosome</a></li> <li><a href="/wiki/Ring_chromosome" title="Ring chromosome">Ring chromosome</a> <ul><li><a href="/w/index.php?title=Ring_chromosome_6&action=edit&redlink=1" class="new" title="Ring chromosome 6 (page does not exist)">6</a>; <a href="/w/index.php?title=Ring_chromosome_9&action=edit&redlink=1" class="new" title="Ring chromosome 9 (page does not exist)">9</a>; <a href="/wiki/Ring_chromosome_14_syndrome" title="Ring chromosome 14 syndrome">14</a>; <a href="/wiki/Ring_chromosome_15" title="Ring chromosome 15">15</a>; <a href="/wiki/Ring_chromosome_18" title="Ring chromosome 18">18</a>; <a href="/wiki/Ring_chromosome_20_syndrome" title="Ring chromosome 20 syndrome">20</a>; <a href="/w/index.php?title=Ring_chromosome_21&action=edit&redlink=1" class="new" title="Ring chromosome 21 (page does not exist)">21</a>, <a href="/wiki/Ring_chromosome_22" title="Ring chromosome 22">22</a></li></ul></li></ul> </div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐5dc468848‐878vc Cached time: 20241122145242 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.467 seconds Real time usage: 0.621 seconds Preprocessor visited node count: 1659/1000000 Post‐expand include size: 102797/2097152 bytes Template argument size: 805/2097152 bytes Highest expansion depth: 10/100 Expensive parser function count: 1/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 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