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{"work":{"id":15540935,"created_at":"2015-09-09T04:29:21.799-07:00","from_world_paper_id":141840756,"updated_at":"2021-01-14T00:56:00.710-08:00","_data":{"publication_date":"2011,,","publication_name":"Asian Pacific Journal of Tropical Medicine"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Protective effect of Polyalthia longifolia var. pendula leaves on ethanol and ethanol/HCl induced ulcer in rats and its antimicrobial potency","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [34695412]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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ds2-5-body-sm">2011, Asian Pacific Journal of Tropical Medicine</p></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":43105886,"attachmentType":"pdf","workUrl":"https://www.academia.edu/15540935/Protective_effect_of_Polyalthia_longifolia_var_pendula_leaves_on_ethanol_and_ethanol_HCl_induced_ulcer_in_rats_and_its_antimicrobial_potency"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":43105886,"attachmentType":"pdf","workUrl":"https://www.academia.edu/15540935/Protective_effect_of_Polyalthia_longifolia_var_pendula_leaves_on_ethanol_and_ethanol_HCl_induced_ulcer_in_rats_and_its_antimicrobial_potency"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download 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href="https://www.academia.edu/106373808/Potential_Effect_of_Medicinal_Plants_on_the_Prevention_of_Gastric_Ulcer_Mechanism_of_Actions">Potential Effect of Medicinal Plants on the Prevention of Gastric Ulcer: Mechanism of Actions</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7386031" href="https://independent.academia.edu/LeeSuanChua">Lee Suan Chua</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Pharmacy and Nutrition Sciences</p><p class="ds-related-work--abstract ds2-5-body-sm">Medicinal plants have been widely studied to identify plant-based anti-gastric ulcer medicines. The mechanism of gastroprotective action is important to discover the potential lead compounds for drug development. All relevant articles between 2011 and 2021 focusing on Malaysian plants were collected and analyzed to understand the underlying pathways. Keywords include peptic ulcer, gastric ulcer, NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), Helicobacterpylori, medicinal plant, gastroprotection, antiulcer, acid secretion, cytoprotective, and digestion processes were applied in the search engines. Twenty-two of the plants had been reported based on the collected data. The review concludes that Malaysian plants could protect the gastric wall against necrotizing agents like ethanol and NSAIDs. This is mainly due to four critical defensive mechanisms: cytoprotective barriers, regulation of heat-shock protein 70 (HSP70) and pro-apoptotic protein (BAX), gastric acid secretion, and antiox...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Potential Effect of Medicinal Plants on the Prevention of Gastric Ulcer: Mechanism of Actions","attachmentId":105589009,"attachmentType":"pdf","work_url":"https://www.academia.edu/106373808/Potential_Effect_of_Medicinal_Plants_on_the_Prevention_of_Gastric_Ulcer_Mechanism_of_Actions","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/106373808/Potential_Effect_of_Medicinal_Plants_on_the_Prevention_of_Gastric_Ulcer_Mechanism_of_Actions"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="22839871" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22839871/Assessment_of_some_Herbal_Drugs_for_Prophylaxis_of_Peptic_Ulcer">Assessment of some Herbal Drugs for Prophylaxis of Peptic Ulcer</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44494567" href="https://independent.academia.edu/AhmedGohar4">Ahmed Gohar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Iranian journal of pharmaceutical research : IJPR, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in Egyptian traditional medicine to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage), B. oleracea Botrytis (cauliflower) aqueous fraction, Portolaca oleracea polysaccharide fraction, Oreganum marjoranum, Matricaria recutita, Solanum nigrum hydrophilic and lipophilic fractions, in addition to the chloroform fraction of Portolaca oleracea and Cicorium intybus afforded high protection against the incidence of gastric ulcer (~95%). O. syriacum hydrophilic and lipophilic fractions and gum arabic afforded moderate prophylactic effect. L. sicerarea, C. intybus hydrophilic fractions and M. microphylla lipophilic fraction were inactive. 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data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/114407892/Peptic_Ulcers_and_Its_Cure_Using_Herbal_Extracts">Peptic Ulcers and Its Cure Using Herbal Extracts</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="278862254" href="https://sjic.academia.edu/DrHindustanAbdulAhad">Dr. Hindustan Abdul Ahad</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Peptic Ulcers and Its Cure Using Herbal Extracts","attachmentId":111114000,"attachmentType":"pdf","work_url":"https://www.academia.edu/114407892/Peptic_Ulcers_and_Its_Cure_Using_Herbal_Extracts","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/114407892/Peptic_Ulcers_and_Its_Cure_Using_Herbal_Extracts"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="49873787" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/49873787/IJPCA_Herbal_drugs_boon_for_peptic_ulcer_patients_pdf">IJPCA-Herbal drugs-boon for peptic ulcer patients.pdf</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="10765599" href="https://gtu-in.academia.edu/TapankumarMahato">TAPAN K U M A R MAHATO</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Pharmaceutical Chemistry and Analysis, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Antibiotic, antiviral, antifungal and antiparasitic medicines are used to treat the diseases caused by pathogenic microorganisms. These microbes effects humans, animals and plants and produces diseases. As per the recent report of World Health Organization (WHO), the cases of Antimicrobial resistance (AMR) is continuously rising, which causes ineffective treatment and prevention of infections caused by bacteria, viruses, fungi and parasites. AMR occurs when these microbes gets resistance and the medications gets ineffective against these microbes, which makes treatment of common infections difficult and consequently increases the risk of severe illness, spread of disease and death. Because the medicines becomes purposeless, infections continue to exist in the body and increases the likeliness of spread to others. WHO recommends reduced use of synthetic antibiotics and raised use of herbal antimicrobial drugs. These are the ways by which the AMR can be controlled or abolished. Herbal drugs can be used for this purpose because these are considered to be effective with no or less side effects. In the present article we discussed about peptic ulcer, causative agent of peptic ulcer and the medicinal plants which can be used to treat this disease. Twenty medicinal plants were listed which contains both antibacterial and antiulcer activity. Due to these properties of these medicinal plants, these can be used for the treatment of peptic ulcer because of dual benefits firstly, antibacterial which kills or retards the growth of Helicobacter pylori and secondly, antiulcer which heals the ulcer.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"IJPCA-Herbal drugs-boon for peptic ulcer patients.pdf","attachmentId":68069494,"attachmentType":"pdf","work_url":"https://www.academia.edu/49873787/IJPCA_Herbal_drugs_boon_for_peptic_ulcer_patients_pdf","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/49873787/IJPCA_Herbal_drugs_boon_for_peptic_ulcer_patients_pdf"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="73898596" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73898596/Herbal_Potentials_for_Treatment_of_Peptic_Ulcers_A_Review">Herbal Potentials for Treatment of Peptic Ulcers: A Review</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4936917" href="https://unigoa.academia.edu/JAGDISHBAHETI">JAGDISH BAHETI</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Pharmaceutical Sciences Review and Research, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">The inflamed break in the skin or mucous membrane lining the elementary tract describes development of ulcer. About 10% of World’s population suffering from peptic ulcer. It is a broad term that includes ulcers of digestive tract, in the stomach or the duodenum. The presence of acid and peptic activity in gastric juice with a breakdown in mucosal defences develops peptic ulcer. It may be occurring due to regular usage of drugs, irregular food habits, stress. The ideal aims of treatment of peptic ulcer disease are to relieve pain, heal the ulcers and delay ulcer recurrence. The availability of number of synthetic drugs such as proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists are conventionally used for treatments of peptic ulcers, associated with adverse effects, relapses, various drug interactions are observed and expensive when compared to herbal medicines. Herbal medicines demand has increased globally. Availability of gastro-protective remedies without side...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Herbal Potentials for Treatment of Peptic Ulcers: A Review","attachmentId":82246456,"attachmentType":"pdf","work_url":"https://www.academia.edu/73898596/Herbal_Potentials_for_Treatment_of_Peptic_Ulcers_A_Review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/73898596/Herbal_Potentials_for_Treatment_of_Peptic_Ulcers_A_Review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="49873256" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/49873256/Herbal_drugs_Boon_for_Peptic_ulcer_patients">Herbal drugs: Boon for Peptic ulcer patients</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="10765599" href="https://gtu-in.academia.edu/TapankumarMahato">TAPAN K U M A R MAHATO</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Pharmaceutical Chemistry and Analysis, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Antibiotic, antiviral, antifungal and antiparasitic medicines are used to treat the diseases caused by pathogenic microorganisms. These microbes effects humans, animals and plants and produces diseases. As per the recent report of World Health Organization (WHO), the cases of Antimicrobial resistance (AMR) is continuously rising, which causes ineffective treatment and prevention of infections caused by bacteria, viruses, fungi and parasites. AMR occurs when these microbes gets resistance and the medications gets ineffective against these microbes, which makes treatment of common infections difficult and consequently increases the risk of severe illness, spread of disease and death. Because the medicines becomes purposeless, infections continue to exist in the body and increases the likeliness of spread to others. WHO recommends reduced use of synthetic antibiotics and raised use of herbal antimicrobial drugs. These are the ways by which the AMR can be controlled or abolished. Herbal drugs can be used for this purpose because these are considered to be effective with no or less side effects. In the present article we discussed about peptic ulcer, causative agent of peptic ulcer and the medicinal plants which can be used to treat this disease. Twenty medicinal plants were listed which contains both antibacterial and antiulcer activity. Due to these properties of these medicinal plants, these can be used for the treatment of peptic ulcer because of dual benefits firstly, antibacterial which kills or retards the growth of Helicobacter pylori and secondly, antiulcer which heals the ulcer.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Herbal drugs: Boon for Peptic ulcer patients","attachmentId":68069299,"attachmentType":"pdf","work_url":"https://www.academia.edu/49873256/Herbal_drugs_Boon_for_Peptic_ulcer_patients","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/49873256/Herbal_drugs_Boon_for_Peptic_ulcer_patients"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="108120643" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/108120643/A_review_on_conventional_and_herbal_drug_approach_to_peptic_ulcer">A review on conventional and herbal drug approach to peptic ulcer</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="138040375" href="https://independent.academia.edu/DrNareshkalra">Dr. Naresh kalra</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Gastroenterology and Hepatology Research</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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